ketamine has been researched along with Neuralgia, Postherpetic in 4 studies
Ketamine: A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.
ketamine : A member of the class of cyclohexanones in which one of the hydrogens at position 2 is substituted by a 2-chlorophenyl group, while the other is substituted by a methylamino group.
Neuralgia, Postherpetic: Pain in nerves, frequently involving facial SKIN, resulting from the activation the latent varicella-zoster virus (HERPESVIRUS 3, HUMAN). The two forms of the condition preceding the pain are HERPES ZOSTER OTICUS; and HERPES ZOSTER OPHTHALMICUS. Following the healing of the rashes and blisters, the pain sometimes persists.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In mixed neuropathic pain, case series reports suggest a favourable response rate, but are limited by trial characteristics." | 5.43 | Topical amitriptyline and ketamine for post-herpetic neuralgia and other forms of neuropathic pain. ( Sawynok, J; Zinger, C, 2016) |
| "In mixed neuropathic pain, case series reports suggest a favourable response rate, but are limited by trial characteristics." | 1.43 | Topical amitriptyline and ketamine for post-herpetic neuralgia and other forms of neuropathic pain. ( Sawynok, J; Zinger, C, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 3 (75.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Griffin, JR | 1 |
| Davis, MD | 1 |
| Kim, YH | 1 |
| Lee, PB | 1 |
| Oh, TK | 1 |
| Sawynok, J | 1 |
| Zinger, C | 1 |
| Zimmer, C | 1 |
| Treschan, TA | 1 |
| Meier, S | 1 |
| Nosch, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Antipruritic Effect of Topical Ketamine, Amitriptyline, and Lidocaine[NCT03096444] | Phase 2 | 13 participants (Actual) | Interventional | 2017-05-23 | Terminated (stopped due to Efficacy was not seen after interim analysis) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Peak itch intensity between the vehicle and 4 other active treatments (individual ketamine, amitriptyline, or lidocaine, and KeAmLi-combo). Itch intensity was measured on a 100mm scale visual analog scale for 10 minutes. 0 was weighted with no itch and 100 was weighted with most itch imaginable." (NCT03096444)
Timeframe: 10 minutes
| Intervention | Intensity score (Mean) |
|---|---|
| Topical KeAmLi Combo | 62.7 |
| Topical Ketamine | 63.1 |
| Topical Amitriptyline | 69.2 |
| Topical Lidocaine | 65.8 |
| Topical Vehicle | 61.9 |
Assess mechanical detection and pain thresholds using von Frey filaments stimulators (measured in force mN) to calculate the final threshold as the geometric mean of five series of ascending and descending stimuli. (NCT03096444)
Timeframe: 5 minutes
| Intervention | mN (Mean) | |
|---|---|---|
| Mechanical Detection Threshold | Mechanical Pain Threshold | |
| Topical Amitriptyline | 3.573423965 | 152.4768146 |
| Topical KeAmLi Combo | 3.519376956 | 152.3293608 |
| Topical Ketamine | 3.464204768 | 135.9 |
| Topical Lidocaine | 3.546037659 | 126.9 |
| Topical Vehicle | 3.525692637 | 148.7138273 |
Two standardized quantitative sensory tests are performed to measure warmth detection threshold (assesses the threshold of which warmth sensation is first detected) and heat pain threshold (assesses the threshold at which heat pain sensation is first detected). Measured in change in celsius. (NCT03096444)
Timeframe: 3 minutes
| Intervention | Degrees celsius (Mean) | |
|---|---|---|
| Warm Detection Threshold | Heat Pain Threshold | |
| Topical Amitriptyline | 33.9 | 40.0 |
| Topical KeAmLi Combo | 33.6 | 39.8 |
| Topical Ketamine | 34.0 | 40.0 |
| Topical Lidocaine | 33.7 | 39.4 |
| Topical Vehicle | 33.8 | 39.7 |
1 trial available for ketamine and Neuralgia, Postherpetic
| Article | Year |
|---|---|
Is magnesium sulfate effective for pain in chronic postherpetic neuralgia patients comparing with ketamine infusion therapy?
Topics: Aged; Aged, 80 and over; Analgesics; Chronic Disease; Double-Blind Method; Female; Follow-Up Studies | 2015 |
3 other studies available for ketamine and Neuralgia, Postherpetic
| Article | Year |
|---|---|
Amitriptyline/Ketamine as therapy for neuropathic pruritus and pain secondary to herpes zoster.
Topics: Administration, Cutaneous; Amitriptyline; Analgesics; Drug Combinations; Gels; Herpes Zoster; Humans | 2015 |
Topical amitriptyline and ketamine for post-herpetic neuralgia and other forms of neuropathic pain.
Topics: Administration, Topical; Amitriptyline; Analgesics; Animals; Diabetic Neuropathies; Drug Combination | 2016 |
[Long-term treatment with oral ketamine. Case report of a female patient with therapy-resistant post-herpetic neuralgia].
Topics: Administration, Oral; Aged; Analgesics; Female; Humans; Ketamine; Long-Term Care; Neuralgia, Posther | 2009 |