ketamine and Coma
ketamine has been researched along with Coma in 8 studies
Ketamine: A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.
ketamine : A member of the class of cyclohexanones in which one of the hydrogens at position 2 is substituted by a 2-chlorophenyl group, while the other is substituted by a methylamino group.
Coma: A profound state of unconsciousness associated with depressed cerebral activity from which the individual cannot be aroused. Coma generally occurs when there is dysfunction or injury involving both cerebral hemispheres or the brain stem RETICULAR FORMATION.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "At this time, there are no studies evaluating the risk of delirium or coma with the use of ketamine in mechanically ventilated adult patients, compared to conventional therapies such as propofol or dexmedetomidine." | 7.96 | Comparison of Ketamine- Versus Nonketamine-Based Sedation on Delirium and Coma in the Intensive Care Unit. ( Patanwala, AE; Radosevich, JJ; Shurtleff, V, 2020) |
| " He received therapeutic coma with intravenous diazepam and sodium thiopental to maintain an electroencephalographic burst suppression pattern, which was maintained for a period of 46 h, as well as intravenous ketamine (48 mg/kg/day) as a continuous infusion and ribavirin (48 to 128 mg/kg/day) via a nasogastric tube." | 7.73 | Failure of therapeutic coma and ketamine for therapy of human rabies. ( Desudchit, T; Hemachudha, T; Jackson, AC; Khawplod, P; Sittipunt, C; Suankratay, C; Sunsaneewitayakul, B; Wacharapluesadee, S; Wilde, H, 2006) |
| "At this time, there are no studies evaluating the risk of delirium or coma with the use of ketamine in mechanically ventilated adult patients, compared to conventional therapies such as propofol or dexmedetomidine." | 3.96 | Comparison of Ketamine- Versus Nonketamine-Based Sedation on Delirium and Coma in the Intensive Care Unit. ( Patanwala, AE; Radosevich, JJ; Shurtleff, V, 2020) |
| " He received therapeutic coma with intravenous diazepam and sodium thiopental to maintain an electroencephalographic burst suppression pattern, which was maintained for a period of 46 h, as well as intravenous ketamine (48 mg/kg/day) as a continuous infusion and ribavirin (48 to 128 mg/kg/day) via a nasogastric tube." | 3.73 | Failure of therapeutic coma and ketamine for therapy of human rabies. ( Desudchit, T; Hemachudha, T; Jackson, AC; Khawplod, P; Sittipunt, C; Suankratay, C; Sunsaneewitayakul, B; Wacharapluesadee, S; Wilde, H, 2006) |
| "Treatment included induction of coma while a native immune response matured; rabies vaccine was not administered." | 1.33 | Survival after treatment of rabies with induction of coma. ( Amlie-Lefond, CM; Chusid, MJ; Ghanayem, NS; Hoffman, GM; Rupprecht, CE; Schwabe, MJ; Tieves, KS; Willoughby, RE, 2005) |
Research
Studies (8)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (62.50) | 29.6817 |
| 2010's | 2 (25.00) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Shurtleff, V | 1 |
| Radosevich, JJ | 1 |
| Patanwala, AE | 1 |
| Prüss, H | 1 |
| Holtkamp, M | 1 |
| van Thiel, PP | 1 |
| de Bie, RM | 1 |
| Eftimov, F | 1 |
| Tepaske, R | 1 |
| Zaaijer, HL | 1 |
| van Doornum, GJ | 1 |
| Schutten, M | 1 |
| Osterhaus, AD | 1 |
| Majoie, CB | 1 |
| Aronica, E | 1 |
| Fehlner-Gardiner, C | 1 |
| Wandeler, AI | 1 |
| Kager, PA | 1 |
| van Amsterdam, JG | 2 |
| Brunt, TM | 2 |
| McMaster, MT | 2 |
| Niesink, RJ | 1 |
| Niesink, R | 1 |
| van Noorden, MS | 1 |
| van den Brink, W | 1 |
| Willoughby, RE | 1 |
| Tieves, KS | 1 |
| Hoffman, GM | 1 |
| Ghanayem, NS | 1 |
| Amlie-Lefond, CM | 1 |
| Schwabe, MJ | 1 |
| Chusid, MJ | 1 |
| Rupprecht, CE | 1 |
| Jackson, AC | 2 |
| Hemachudha, T | 1 |
| Sunsaneewitayakul, B | 1 |
| Desudchit, T | 1 |
| Suankratay, C | 1 |
| Sittipunt, C | 1 |
| Wacharapluesadee, S | 1 |
| Khawplod, P | 1 |
| Wilde, H | 1 |
Clinical Trials (1)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Pilot Study to Assess the Efficacy of Subanesthetic Doses of IV Ketamine in the Treatment Drug Resistant Epilepsy[NCT05019885] | Phase 2 | 6 participants (Anticipated) | Interventional | 2022-08-26 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Reviews
2 reviews available for ketamine and Coma
| Article | Year |
|---|---|
Possible long-term effects of γ-hydroxybutyric acid (GHB) due to neurotoxicity and overdose.
Topics: Alcoholism; Anesthetics; Anesthetics, Dissociative; Animals; Central Nervous System Depressants; Cog | 2012 |
[Cognitive impairment due to intensive use and overdoses of gammahydroxybutyric acid (GHB)].
Topics: Cognition; Coma; Drug Overdose; Ethanol; Humans; Hydroxybutyrates; Illicit Drugs; Ketamine; Neurotox | 2012 |
Other Studies
6 other studies available for ketamine and Coma
| Article | Year |
|---|---|
Comparison of Ketamine- Versus Nonketamine-Based Sedation on Delirium and Coma in the Intensive Care Unit.
Topics: Academic Medical Centers; Aged; Coma; Critical Care Outcomes; Delirium; Dexmedetomidine; Female; Hum | 2020 |
Ketamine successfully terminates malignant status epilepticus.
Topics: Anesthesia, General; Anesthetics, Dissociative; Anticonvulsants; Coma; DNA Polymerase gamma; DNA-Dir | 2008 |
Fatal human rabies due to Duvenhage virus from a bat in Kenya: failure of treatment with coma-induction, ketamine, and antiviral drugs.
Topics: Adult; Animals; Antiviral Agents; Chiroptera; Coma; Fatal Outcome; Female; Humans; Kenya; Ketamine; | 2009 |
Survival after treatment of rabies with induction of coma.
Topics: Adolescent; Amantadine; Anesthetics; Animals; Antiviral Agents; Athetosis; Benzodiazepines; Bites an | 2005 |
Recovery from rabies.
Topics: Amantadine; Anesthetics; Animals; Antiviral Agents; Bites and Stings; Chiroptera; Coma; Excitatory A | 2005 |
Failure of therapeutic coma and ketamine for therapy of human rabies.
Topics: Adult; Animals; Brain; Coma; Disease Models, Animal; Excitatory Amino Acid Antagonists; Fatal Outcom | 2006 |