ketamine has been researched along with Spinal Cord Injuries in 23 studies
Ketamine: A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.
ketamine : A member of the class of cyclohexanones in which one of the hydrogens at position 2 is substituted by a 2-chlorophenyl group, while the other is substituted by a methylamino group.
Spinal Cord Injuries: Penetrating and non-penetrating injuries to the spinal cord resulting from traumatic external forces (e.g., WOUNDS, GUNSHOT; WHIPLASH INJURIES; etc.).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Ketamine but not lidocaine showed a significant analgesic effect in patients with neuropathic pain after spinal cord injury." | 9.11 | The analgesic effect of intravenous ketamine and lidocaine on pain after spinal cord injury. ( Gordh, T; Karlsten, R; Kvarnström, A; Quiding, H, 2004) |
| ": To determine the effect of low-dose ketamine on the voltage needed to elicit maximal amplitude of the motor-evoked response to transcranial electrical stimulation during propofol/remifentanil anesthesia in children undergoing scoliosis surgery." | 5.12 | Effect of low-dose ketamine on voltage requirement for transcranial electrical motor evoked potentials in children. ( Crawford, MW; Engelhardt, T; Lewis, S; Pehora, C; Strantzas, S; Zaarour, C, 2007) |
| "Ketamine but not lidocaine showed a significant analgesic effect in patients with neuropathic pain after spinal cord injury." | 5.11 | The analgesic effect of intravenous ketamine and lidocaine on pain after spinal cord injury. ( Gordh, T; Karlsten, R; Kvarnström, A; Quiding, H, 2004) |
| "Although ketamine is widely used as an analgesic agent and has an anti-allodynic effect on neuropathic pain, the underlying analgesic mechanisms are not fully explained by the modern 'neuronal-based' theories." | 3.75 | Inhibiting astrocytic activation: a novel analgesic mechanism of ketamine at the spinal level? ( Li, Y; Mei, X; Wang, W; Wu, S; Xu, L; Zhang, H, 2009) |
| "Pain was evoked by non-noxious stimulation of the skin (allodynia) and by repeated pricking of the skin (wind-up-like pain)." | 2.68 | Central dysesthesia pain after traumatic spinal cord injury is dependent on N-methyl-D-aspartate receptor activation. ( Eide, PK; Stenehjem, AE; Stubhaug, A, 1995) |
| "The pulmonary index (100 x wet lung weight/body weight) was 0." | 1.33 | Importance of anesthesia for the genesis of neurogenic pulmonary edema in spinal cord injury. ( Borges, G; Cambiucci, EC; de Almeida, AR; Gontijo, JA; Leal Filho, MB; Metze, K; Morandin, RC, 2005) |
| "6) litre kg(-1), and the elimination half-life was 4." | 1.32 | Pharmacokinetics and haemodynamics of ketamine in intensive care patients with brain or spinal cord injury. ( Bodonian, C; Bolon, M; Boulieu, R; Hijazi, Y; Salord, F, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.35) | 18.7374 |
| 1990's | 6 (26.09) | 18.2507 |
| 2000's | 8 (34.78) | 29.6817 |
| 2010's | 7 (30.43) | 24.3611 |
| 2020's | 1 (4.35) | 2.80 |
| Authors | Studies |
|---|---|
| Asgardoon, MH | 1 |
| Jazayeri, SB | 1 |
| Behkar, A | 1 |
| Dabbagh Ohadi, MA | 1 |
| Yarmohammadi, H | 1 |
| Ghodsi, Z | 1 |
| Pomerani, TI | 1 |
| Mojtahedzadeh, M | 1 |
| Rahimi-Movaghar, V | 1 |
| Kim, K | 1 |
| Mishina, M | 1 |
| Kokubo, R | 1 |
| Nakajima, T | 1 |
| Morimoto, D | 1 |
| Isu, T | 1 |
| Kobayashi, S | 1 |
| Teramoto, A | 1 |
| M'Dahoma, S | 1 |
| Bourgoin, S | 1 |
| Kayser, V | 1 |
| Barthélémy, S | 1 |
| Chevarin, C | 1 |
| Chali, F | 1 |
| Orsal, D | 1 |
| Hamon, M | 1 |
| Tang, SH | 1 |
| Yu, JG | 1 |
| Li, JJ | 1 |
| Sun, JY | 1 |
| Yazihan, N | 1 |
| Uzuner, K | 1 |
| Salman, B | 1 |
| Vural, M | 1 |
| Koken, T | 1 |
| Arslantas, A | 1 |
| Mei, X | 1 |
| Wang, W | 2 |
| Li, Y | 2 |
| Zhang, H | 1 |
| Wu, S | 1 |
| Xu, L | 1 |
| Agrawal, G | 1 |
| Iyer, S | 2 |
| All, AH | 2 |
| Maybhate, A | 1 |
| Presacco, A | 1 |
| Kose, EA | 1 |
| Bakar, B | 1 |
| Ayva, SK | 1 |
| Kilinc, K | 1 |
| Apan, A | 1 |
| Hama, A | 1 |
| Sagen, J | 1 |
| Hussain, AM | 1 |
| Khan, MA | 1 |
| Ho, SM | 1 |
| Waite, PM | 1 |
| Hijazi, Y | 1 |
| Bodonian, C | 1 |
| Bolon, M | 1 |
| Salord, F | 1 |
| Boulieu, R | 1 |
| Kvarnström, A | 1 |
| Karlsten, R | 1 |
| Quiding, H | 1 |
| Gordh, T | 1 |
| Leal Filho, MB | 1 |
| Morandin, RC | 1 |
| de Almeida, AR | 1 |
| Cambiucci, EC | 1 |
| Borges, G | 1 |
| Gontijo, JA | 1 |
| Metze, K | 1 |
| Zaarour, C | 1 |
| Engelhardt, T | 1 |
| Strantzas, S | 1 |
| Pehora, C | 1 |
| Lewis, S | 1 |
| Crawford, MW | 1 |
| Grissom, TE | 1 |
| Mitzel, HC | 1 |
| Bunegin, L | 1 |
| Albin, MS | 1 |
| Eide, PK | 1 |
| Stubhaug, A | 1 |
| Stenehjem, AE | 1 |
| Watt, JW | 1 |
| Fraser, MH | 1 |
| Soni, BM | 1 |
| Sett, PK | 1 |
| Clay, R | 1 |
| Mion, G | 1 |
| Rüttimann, M | 1 |
| Daniel, L | 1 |
| Taylor, J | 1 |
| Munson, J | 1 |
| Vierck, C | 1 |
| Lucas, JH | 1 |
| Wang, GF | 1 |
| Gross, GW | 1 |
| Levy, W | 1 |
| McCaffrey, M | 1 |
| York, D | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Study of the Efficiency of the Ketamine With Low Analgesic Doses, in Association With High Opioids, in the Treatment of the Rebels Pains, in Palliative Phase of the Cancerous Disease[NCT01326325] | Phase 3 | 24 participants (Actual) | Interventional | 2011-07-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for ketamine and Spinal Cord Injuries
| Article | Year |
|---|---|
Pharmacologic therapies of pain in patients with spinal cord injury: a systematic review.
Topics: Amitriptyline; Anticonvulsants; Gabapentin; Humans; Ketamine; Pain; Pregabalin; Spinal Cord Injuries | 2022 |
3 trials available for ketamine and Spinal Cord Injuries
| Article | Year |
|---|---|
The analgesic effect of intravenous ketamine and lidocaine on pain after spinal cord injury.
Topics: Adult; Analgesics; Analysis of Variance; Anesthetics, Local; Cross-Over Studies; Double-Blind Method | 2004 |
Effect of low-dose ketamine on voltage requirement for transcranial electrical motor evoked potentials in children.
Topics: Adolescent; Anesthetics, Dissociative; Anesthetics, Intravenous; Child; Dose-Response Relationship, | 2007 |
Central dysesthesia pain after traumatic spinal cord injury is dependent on N-methyl-D-aspartate receptor activation.
Topics: Adult; Aged; Alfentanil; Analgesics, Opioid; Double-Blind Method; Excitatory Amino Acid Antagonists; | 1995 |
19 other studies available for ketamine and Spinal Cord Injuries
| Article | Year |
|---|---|
Ketamine for acute neuropathic pain in patients with spinal cord injury.
Topics: Adult; Aged; Aged, 80 and over; Analgesics; Female; Humans; Ketamine; Magnetic Resonance Imaging; Ma | 2013 |
Spinal cord transection-induced allodynia in rats--behavioral, physiopathological and pharmacological characterization.
Topics: Activating Transcription Factor 3; Analysis of Variance; Animals; Cytokines; Ganglia, Spinal; Hot Te | 2014 |
Neuroprotective effect of ketamine on acute spinal cord injury in rats.
Topics: Acute Disease; Animals; Apoptosis; Excitatory Amino Acid Antagonists; In Situ Nick-End Labeling; Inj | 2015 |
Erythropoietin improves oxidative stress following spinal cord trauma in rats.
Topics: Analgesics; Animals; Antioxidants; Erythropoietin; Glutathione; Ketamine; Lipid Peroxidation; Malond | 2008 |
Inhibiting astrocytic activation: a novel analgesic mechanism of ketamine at the spinal level?
Topics: Analgesics; Anesthesia; Animals; Astrocytes; Disease Models, Animal; Drug Administration Routes; Gli | 2009 |
A comparative study of recording procedures for motor evoked potential signals.
Topics: Analysis of Variance; Anesthesia; Anesthetics; Animals; Electric Stimulation; Electrodes, Implanted; | 2009 |
Multi-limb acquisition of motor evoked potentials and its application in spinal cord injury.
Topics: Analgesics; Animals; Biophysics; Disease Models, Animal; Electric Stimulation; Evoked Potentials, Mo | 2010 |
Neuroprotective effects of racemic ketamine and (S)-ketamine on spinal cord injury in rat.
Topics: Animals; Disease Models, Animal; Injections, Intraperitoneal; Ketamine; Laminectomy; Lipid Peroxidat | 2012 |
Combinations of intrathecal gamma-amino-butyrate receptor agonists and N-methyl-d-aspartate receptor antagonists in rats with neuropathic spinal cord injury pain.
Topics: Analgesia, Epidural; Animals; Baclofen; Dose-Response Relationship, Drug; Drug Synergism; Drug Thera | 2012 |
Pain management after traumatic spinal cord injury.
Topics: Adult; Analgesics; Anesthetics, Local; Dose-Response Relationship, Drug; Follow-Up Studies; Humans; | 2012 |
Effects of different anesthetics on the paired-pulse depression of the h reflex in adult rat.
Topics: Administration, Inhalation; Alfaxalone Alfadolone Mixture; Anesthetics; Animals; Disease Models, Ani | 2002 |
Pharmacokinetics and haemodynamics of ketamine in intensive care patients with brain or spinal cord injury.
Topics: Adult; Analysis of Variance; Anesthetics, Dissociative; Blood Pressure; Brain Injuries; Critical Car | 2003 |
Importance of anesthesia for the genesis of neurogenic pulmonary edema in spinal cord injury.
Topics: Anesthetics, General; Animals; Blood Pressure; Ketamine; Lung; Microscopy, Electron, Transmission; P | 2005 |
The effect of anesthetics on neurologic outcome during the recovery period of spinal cord injury in rats.
Topics: Anesthetics; Animals; Central Nervous System; Female; Fentanyl; Isoflurane; Ketamine; Nitrous Oxide; | 1994 |
Total i.v. anaesthesia for transcranial magnetic evoked potential spinal cord monitoring.
Topics: Adult; Alfentanil; Anesthesia, Intravenous; Anesthetics, Dissociative; Anesthetics, Inhalation; Evok | 1996 |
[Infra-anesthetic ketamine dosage in the treatment of neuropathic-type pain].
Topics: Adult; Anesthetics, Dissociative; Humans; Ketamine; Male; Pain, Intractable; Spinal Cord Injuries | 1997 |
Effects of dorsolateral spinal lesions on stretch reflex threshold and stiffness in awake cats.
Topics: Anesthetics, Dissociative; Animals; Cats; Electromyography; Female; Ketamine; Muscle Spasticity; Mus | 1999 |
NMDA antagonists prevent hypothermic injury and death of mammalian spinal neurons.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cell Survival; Dizocilpine Maleate; Female; Freezing; Hypother | 1990 |
Motor evoked potential in cats with acute spinal cord injury.
Topics: Animals; Blood Pressure; Cats; Chloralose; Evoked Potentials; Evoked Potentials, Somatosensory; Keta | 1986 |