ketamine has been researched along with Cognitive Decline in 49 studies
Ketamine: A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.
ketamine : A member of the class of cyclohexanones in which one of the hydrogens at position 2 is substituted by a 2-chlorophenyl group, while the other is substituted by a methylamino group.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Previous study showed that ketamine could reduce suicidal ideation (SI), potentially by improving the impaired working memory (WM)." | 9.41 | Working memory associated with anti-suicidal ideation effect of repeated-dose intravenous ketamine in depressed patients. ( Chen, X; Hu, Y; Lan, X; Li, H; Liu, W; Ning, Y; Wang, C; Wang, M; Zhan, Y; Zhang, B; Zheng, W; Zhong, X; Zhou, Y, 2021) |
| "None of the three study arms - haloperidol, ketamine, or both drugs combined - was significantly superior to placebo for prevention of postoperative brain dysfunction and delirium (P = 0." | 9.41 | Ketamine vs. haloperidol for prevention of cognitive dysfunction and postoperative delirium: A phase IV multicentre randomised placebo-controlled double-blind clinical trial. ( Brügger, J; Gysi, B; Hollinger, A; Huber, J; Rentsch, K; Riegger, H; Rüst, CA; Schmid, HR; Siegemund, M; Steiner, L; Surbeck, M; Toft, K; Tran, F, 2021) |
| "The effect of ketamine on postoperative delirium remains unclear but its administration may offer some protection towards POCD." | 8.98 | Intraoperative ketamine administration to prevent delirium or postoperative cognitive dysfunction: A systematic review and meta-analysis. ( Beck-Schimmer, B; Hovaguimian, F; Puhan, M; Tschopp, C, 2018) |
| "Cannabidiol (CBD), a non-psychotropic cannabinoid, demonstrates antipsychotic-like and procognitive activities in humans and in animal models of schizophrenia." | 7.96 | Cannabidiol Improves Cognitive Impairment and Reverses Cortical Transcriptional Changes Induced by Ketamine, in Schizophrenia-Like Model in Rats. ( Juknat, A; Kos, T; Kozela, E; Krawczyk, M; Popik, P; Vogel, Z, 2020) |
| "Early life exposure to ketamine caused neurohistopathologic changes and persistent cognitive dysfunction." | 7.85 | Long-term neurocognitive dysfunction in offspring via NGF/ ERK/CREB signaling pathway caused by ketamine exposure during the second trimester of pregnancy in rats. ( Chen, Y; Gao, L; Guo, C; Li, L; Li, X; Li, Y; Liu, W; Wang, Y; Zhang, Y, 2017) |
| "EA could increase the contents of anti-Abeta antibodies in aged rats with ketamine anesthesia, decrease the expression of Abeta in the hippocampus, alleviate the deposition of Abeta, thus improving rats' cognitive dysfunction." | 7.77 | [Effect of electroacupuncture on the cognitive function and plasma antibodies against beta-amyloid protein in aged rats with ketamine anesthesia]. ( Jiang, DY; Lu, HW, 2011) |
| "Schizophrenia is a serious neuropsychiatric disorder characterized by the presence of positive symptoms (hallucinations, delusions, and disorganization of thought and language), negative symptoms (abulia, alogia, and affective flattening), and cognitive impairment (attention deficit, impaired declarative memory, and deficits in social cognition)." | 7.01 | Ketamine as a pharmacological tool for the preclinical study of memory deficit in schizophrenia. ( Picazo, O; Roldán, GR; Suárez Santiago, JE, 2023) |
| "Depression is a well-known serious mental illness, and the onset of treatment using traditional antidepressants is frequently delayed by several weeks." | 7.01 | Ketamine and its metabolites: Potential as novel treatments for depression. ( Hashimoto, K; Yao, Y; Zhang, K, 2023) |
| "Ketamine has been reported to attenuate POCD after cardiac surgery." | 5.72 | Esketamine alleviates postoperative cognitive decline via stimulator of interferon genes/ TANK-binding kinase 1 signaling pathway in aged rats. ( Gao, JG; Li, Y; Song, RX; Wang, JX; Wu, ZY; Zheng, WC, 2022) |
| "Schizophrenia is a complex neuropsychiatric disorder characterized by hallucinations, delusions, anhedonia, flat affect and cognitive impairments." | 5.48 | Prenatal exposure to ketamine in rats: Implications on animal models of schizophrenia. ( Coronel-Oliveros, CM; Pacheco-Calderón, R, 2018) |
| "The oleuropein-pretreated groups received oleuropein (15 mg/kg body weight as orally) for 10 consecutive days." | 5.46 | Oleuropein attenuates cognitive dysfunction and oxidative stress induced by some anesthetic drugs in the hippocampal area of rats. ( Alirezaei, M; Hajighahramani, S; Kiani, K; Rezaei, M; Sookhtehzari, A, 2017) |
| "Ketamine has rapid antidepressant efficacy, but it is unknown if ketamine improves cognitive symptoms." | 5.46 | Ketamine Corrects Stress-Induced Cognitive Dysfunction through JAK2/STAT3 Signaling in the Orbitofrontal Cortex. ( Girotti, M; Lodge, DJ; Morilak, DA; Patton, MS, 2017) |
| " Previous study showed that ketamine could reduce suicidal ideation (SI), potentially by improving the impaired working memory (WM)." | 5.41 | Working memory associated with anti-suicidal ideation effect of repeated-dose intravenous ketamine in depressed patients. ( Chen, X; Hu, Y; Lan, X; Li, H; Liu, W; Ning, Y; Wang, C; Wang, M; Zhan, Y; Zhang, B; Zheng, W; Zhong, X; Zhou, Y, 2021) |
| "None of the three study arms - haloperidol, ketamine, or both drugs combined - was significantly superior to placebo for prevention of postoperative brain dysfunction and delirium (P = 0." | 5.41 | Ketamine vs. haloperidol for prevention of cognitive dysfunction and postoperative delirium: A phase IV multicentre randomised placebo-controlled double-blind clinical trial. ( Brügger, J; Gysi, B; Hollinger, A; Huber, J; Rentsch, K; Riegger, H; Rüst, CA; Schmid, HR; Siegemund, M; Steiner, L; Surbeck, M; Toft, K; Tran, F, 2021) |
| "The effect of ketamine on postoperative delirium remains unclear but its administration may offer some protection towards POCD." | 4.98 | Intraoperative ketamine administration to prevent delirium or postoperative cognitive dysfunction: A systematic review and meta-analysis. ( Beck-Schimmer, B; Hovaguimian, F; Puhan, M; Tschopp, C, 2018) |
| "The implications of these findings are drawn out for treatment of ketamine-induced ulcerative cystitis in which interventions from urologists and from addiction specialists should be coordinated." | 4.88 | Ketamine use: a review. ( Curran, HV; Morgan, CJ, 2012) |
| "Multiple studies have revealed that repeated or long-term exposure to ketamine causes neurodegeneration and cognitive dysfunction." | 4.02 | Blockade of the NLRP3/caspase-1 axis attenuates ketamine-induced hippocampus pyroptosis and cognitive impairment in neonatal rats. ( Bai, H; Gao, L; Li, R; Li, S; Ma, X; Qiu, D; Shen, M; Zhang, Z, 2021) |
| "Cannabidiol (CBD), a non-psychotropic cannabinoid, demonstrates antipsychotic-like and procognitive activities in humans and in animal models of schizophrenia." | 3.96 | Cannabidiol Improves Cognitive Impairment and Reverses Cortical Transcriptional Changes Induced by Ketamine, in Schizophrenia-Like Model in Rats. ( Juknat, A; Kos, T; Kozela, E; Krawczyk, M; Popik, P; Vogel, Z, 2020) |
| "In this longitudinal study, 114 ketamine users completed clinical and cognitive assessments at both baseline and 12-week follow-up with the following instruments: Severity of Dependence Scale, Beck Depression Inventory (BDI), Anxiety Subscale of the Hospital Anxiety Depression Scale (HADSA), and a cognitive battery." | 3.91 | Recovery of cognitive functioning following abstinence from ketamine. ( Lane, HY; Lau, CG; Lin, SK; Tang, WK; Ungvari, GS, 2019) |
| "Ketamine has been used to probe the biology of psychosis and cognitive dysfunction in humans." | 3.88 | Similar psychotic and cognitive profile between ketamine dependence with persistent psychosis and schizophrenia. ( Chen, CH; Chen, CK; Cheng, WJ; Huang, MC; Krystal, JH; Pietrzak, RH; Xu, K, 2018) |
| "Early life exposure to ketamine caused neurohistopathologic changes and persistent cognitive dysfunction." | 3.85 | Long-term neurocognitive dysfunction in offspring via NGF/ ERK/CREB signaling pathway caused by ketamine exposure during the second trimester of pregnancy in rats. ( Chen, Y; Gao, L; Guo, C; Li, L; Li, X; Li, Y; Liu, W; Wang, Y; Zhang, Y, 2017) |
| "EA could increase the contents of anti-Abeta antibodies in aged rats with ketamine anesthesia, decrease the expression of Abeta in the hippocampus, alleviate the deposition of Abeta, thus improving rats' cognitive dysfunction." | 3.77 | [Effect of electroacupuncture on the cognitive function and plasma antibodies against beta-amyloid protein in aged rats with ketamine anesthesia]. ( Jiang, DY; Lu, HW, 2011) |
| "Schizophrenia is a serious neuropsychiatric disorder characterized by the presence of positive symptoms (hallucinations, delusions, and disorganization of thought and language), negative symptoms (abulia, alogia, and affective flattening), and cognitive impairment (attention deficit, impaired declarative memory, and deficits in social cognition)." | 3.01 | Ketamine as a pharmacological tool for the preclinical study of memory deficit in schizophrenia. ( Picazo, O; Roldán, GR; Suárez Santiago, JE, 2023) |
| "Depression is a well-known serious mental illness, and the onset of treatment using traditional antidepressants is frequently delayed by several weeks." | 3.01 | Ketamine and its metabolites: Potential as novel treatments for depression. ( Hashimoto, K; Yao, Y; Zhang, K, 2023) |
| "Arketamine has been found to have more potent antidepressant-like actions than esketamine in rodents." | 3.01 | Arketamine for cognitive impairment in psychiatric disorders. ( Hashimoto, K, 2023) |
| "Elderly patients are prone to postoperative cognitive dysfunction (POCD)." | 3.01 | Effects of anesthetic adjunctive agents on postoperative cognitive dysfunction in elderly patients undergoing noncardiac surgery: A Bayesian network meta-analysis. ( Huang, Y; Xu, L; Xu, S; Zhang, Y, 2023) |
| "Esketamine was associated with cognitive performance decline, and greater effort was required to complete the test battery versus placebo at 40 min postdose, which returned to placebo-comparable levels by 2 h postdose." | 2.87 | Effect of intranasal esketamine on cognitive functioning in healthy participants: a randomized, double-blind, placebo-controlled study. ( Drevets, WC; Fedgchin, M; Lim, KS; Morrison, RL; Singh, J; van der Ark, P; Van Gerven, J; Wajs, E; Xi, L; Zannikos, P; Zuiker, R, 2018) |
| "Ketamine has been reported to attenuate POCD after cardiac surgery." | 1.72 | Esketamine alleviates postoperative cognitive decline via stimulator of interferon genes/ TANK-binding kinase 1 signaling pathway in aged rats. ( Gao, JG; Li, Y; Song, RX; Wang, JX; Wu, ZY; Zheng, WC, 2022) |
| "Ketamine (KET) is widely used for induction and maintenance of anesthesia, and long-term use is required for treatment of depression patients." | 1.72 | Ulinastatin Alleviates Repetitive Ketamine Exposure-Evoked Cognitive Impairment in Adolescent Mice. ( Hong, Y; Liu, J; Liu, T; Meng, S; Wang, S, 2022) |
| "Ketamine is a frequently used anesthetic in pediatric patients that can cause cognitive impairment." | 1.62 | Genistein attenuates cognitive deficits and neuroapoptosis in hippocampus induced by ketamine exposure in neonatal rats. ( Li, Q; Zhang, X, 2021) |
| "Compared to healthy controls, cognitive impairments were found in ketamine users, including in verbal/visual memory and executive function." | 1.56 | Cognitive impairment in chronic ketamine abusers. ( Hao, W; Tang, WK; Xu, Y; Zhang, B; Zhang, C, 2020) |
| " To evaluate the toxic effects of chronic administration of low ketamine doses on the memory, testicles, and erection, explore its pathophysiology through oxidative stress mechanism and examine the ameliorating effect of N-acetyl cysteine (NAC)." | 1.56 | Neurobehavioral, testicular and erectile impairments of chronic ketamine administration: Pathogenesis and ameliorating effect of N-acetyl cysteine. ( Abd El-Rady, NM; Ahmed, AM; El Shehaby, DM; El-Mahdy, RI; Hosny, A, 2020) |
| "Pregnancy is a key period for the development and growth of offspring." | 1.56 | Ketamine exerts neurotoxic effects on the offspring of pregnant rats via the Wnt/β-catenin pathway. ( Chang, T; Gao, L; Liu, W; Wang, Q; Zhang, X; Zhao, J, 2020) |
| "Ketamine is a racemic mixture of equal amounts of the enantiomers (R)-ketamine and (S)-ketamine." | 1.51 | Cognitive Impairment That Is Induced by (R)-Ketamine Is Abolished in NMDA GluN2D Receptor Subunit Knockout Mice. ( Hashimoto, K; Ide, S; Ikeda, K; Ikekubo, Y; Mishina, M, 2019) |
| "Ketamine is a non-competitive NMDA receptor antagonist used as a major anesthetic agent, especially in children." | 1.51 | Oral ketamine alleviates behavioral despair without cognitive impairment in Wistar rats. ( Canbeyli, R; Ecevitoglu, A; Unal, G, 2019) |
| "Schizophrenia is a complex neuropsychiatric disorder characterized by hallucinations, delusions, anhedonia, flat affect and cognitive impairments." | 1.48 | Prenatal exposure to ketamine in rats: Implications on animal models of schizophrenia. ( Coronel-Oliveros, CM; Pacheco-Calderón, R, 2018) |
| "Ketamine abuse causes cognitive impairments, which negatively impact on users' abstinence, prognosis, and quality of life." | 1.48 | Other drug use does not impact cognitive impairments in chronic ketamine users. ( Liang, HJ; Lin, SK; Tang, WK; Ungvari, GS; Zhang, C, 2018) |
| "Chronic ketamine users had cognitive impairments across multiple domains." | 1.48 | The profile of cognitive impairments in chronic ketamine users. ( Deng, X; Ding, Y; Fan, N; He, H; Ke, X; Liu, Y; Ning, Y; Wang, D; Xu, K; Zhang, X; Zhou, C; Zhou, Y, 2018) |
| "The oleuropein-pretreated groups received oleuropein (15 mg/kg body weight as orally) for 10 consecutive days." | 1.46 | Oleuropein attenuates cognitive dysfunction and oxidative stress induced by some anesthetic drugs in the hippocampal area of rats. ( Alirezaei, M; Hajighahramani, S; Kiani, K; Rezaei, M; Sookhtehzari, A, 2017) |
| "Ketamine has rapid antidepressant efficacy, but it is unknown if ketamine improves cognitive symptoms." | 1.46 | Ketamine Corrects Stress-Induced Cognitive Dysfunction through JAK2/STAT3 Signaling in the Orbitofrontal Cortex. ( Girotti, M; Lodge, DJ; Morilak, DA; Patton, MS, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 21 (42.86) | 24.3611 |
| 2020's | 28 (57.14) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, Z | 1 |
| Bai, H | 1 |
| Ma, X | 1 |
| Shen, M | 1 |
| Li, R | 1 |
| Qiu, D | 1 |
| Li, S | 1 |
| Gao, L | 3 |
| Korlatowicz, A | 1 |
| Kuśmider, M | 1 |
| Szlachta, M | 1 |
| Pabian, P | 1 |
| Solich, J | 1 |
| Dziedzicka-Wasylewska, M | 1 |
| Faron-Górecka, A | 1 |
| Liu, J | 2 |
| Yu, D | 1 |
| Li, J | 1 |
| Barreto Chang, OL | 1 |
| Kreuzer, M | 1 |
| Morgen, DF | 1 |
| Possin, KL | 1 |
| García, PS | 1 |
| Kelle, I | 1 |
| Eriman, H | 1 |
| Erdinc, M | 1 |
| Uyar, E | 1 |
| Li, Y | 2 |
| Wu, ZY | 1 |
| Zheng, WC | 1 |
| Wang, JX | 1 |
| Song, RX | 1 |
| Gao, JG | 1 |
| Suárez Santiago, JE | 1 |
| Roldán, GR | 1 |
| Picazo, O | 1 |
| Zhang, K | 1 |
| Yao, Y | 1 |
| Hashimoto, K | 3 |
| Hong, Y | 1 |
| Meng, S | 1 |
| Wang, S | 1 |
| Liu, T | 1 |
| Katsanou, L | 1 |
| Fragkiadaki, E | 1 |
| Kampouris, S | 1 |
| Konstanta, A | 1 |
| Vontzou, A | 1 |
| Pitsikas, N | 1 |
| Xu, L | 1 |
| Xu, S | 1 |
| Zhang, Y | 2 |
| Huang, Y | 1 |
| Fellous, S | 1 |
| Dubost, B | 1 |
| Cambriel, A | 1 |
| Bonnet, MP | 1 |
| Verdonk, F | 1 |
| Romani, S | 1 |
| Jacquet, B | 1 |
| Cohen, D | 1 |
| Curiale, V | 1 |
| Laurent, I | 1 |
| Louchart De La Chapelle, S | 1 |
| Tang, WK | 3 |
| Lau, CG | 1 |
| Ungvari, GS | 2 |
| Lin, SK | 2 |
| Lane, HY | 1 |
| Zhang, X | 3 |
| Zhao, J | 1 |
| Chang, T | 1 |
| Wang, Q | 2 |
| Liu, W | 3 |
| Wu, C | 1 |
| Wang, Y | 2 |
| He, Y | 1 |
| Wu, S | 1 |
| Xie, Z | 1 |
| Zhang, J | 1 |
| Shen, J | 1 |
| Wang, Z | 1 |
| He, L | 1 |
| Kozela, E | 1 |
| Krawczyk, M | 2 |
| Kos, T | 2 |
| Juknat, A | 1 |
| Vogel, Z | 1 |
| Popik, P | 3 |
| Nikiforuk, A | 2 |
| Litwa, E | 1 |
| Arias, H | 1 |
| Lopes-Aguiar, C | 1 |
| Ruggiero, RN | 1 |
| Rossignoli, MT | 1 |
| Esteves, IM | 1 |
| Peixoto-Santos, JE | 1 |
| Romcy-Pereira, RN | 1 |
| Leite, JP | 1 |
| El Shehaby, DM | 1 |
| El-Mahdy, RI | 1 |
| Ahmed, AM | 1 |
| Hosny, A | 1 |
| Abd El-Rady, NM | 1 |
| Li, Q | 1 |
| Zhang, C | 2 |
| Xu, Y | 1 |
| Zhang, B | 2 |
| Hao, W | 1 |
| Hollinger, A | 1 |
| Rüst, CA | 1 |
| Riegger, H | 1 |
| Gysi, B | 1 |
| Tran, F | 1 |
| Brügger, J | 1 |
| Huber, J | 1 |
| Toft, K | 1 |
| Surbeck, M | 1 |
| Schmid, HR | 1 |
| Rentsch, K | 1 |
| Steiner, L | 1 |
| Siegemund, M | 1 |
| Medina-Kirchner, C | 1 |
| Evans, V | 1 |
| Zou, L | 1 |
| Min, S | 2 |
| Chen, Q | 2 |
| Li, X | 2 |
| Ren, L | 2 |
| Chen, X | 1 |
| Wang, M | 1 |
| Hu, Y | 1 |
| Zhan, Y | 1 |
| Zhou, Y | 2 |
| Zheng, W | 1 |
| Wang, C | 1 |
| Zhong, X | 1 |
| Li, H | 1 |
| Lan, X | 1 |
| Ning, Y | 2 |
| Li, M | 1 |
| Yang, Y | 1 |
| Ma, Y | 1 |
| Guo, C | 1 |
| Li, L | 1 |
| Chen, Y | 1 |
| Coronel-Oliveros, CM | 1 |
| Pacheco-Calderón, R | 1 |
| Morrison, RL | 1 |
| Fedgchin, M | 1 |
| Singh, J | 1 |
| Van Gerven, J | 1 |
| Zuiker, R | 1 |
| Lim, KS | 1 |
| van der Ark, P | 1 |
| Wajs, E | 1 |
| Xi, L | 1 |
| Zannikos, P | 1 |
| Drevets, WC | 1 |
| D'Souza, DC | 2 |
| Carson, RE | 1 |
| Driesen, N | 1 |
| Johannesen, J | 1 |
| Ranganathan, M | 2 |
| Krystal, JH | 2 |
| Cheng, WJ | 1 |
| Chen, CH | 1 |
| Chen, CK | 1 |
| Huang, MC | 1 |
| Pietrzak, RH | 1 |
| Xu, K | 2 |
| Liang, HJ | 1 |
| Man, DWK | 1 |
| Ke, X | 1 |
| Ding, Y | 1 |
| He, H | 1 |
| Wang, D | 1 |
| Deng, X | 1 |
| Zhou, C | 1 |
| Liu, Y | 1 |
| Fan, N | 1 |
| Hovaguimian, F | 1 |
| Tschopp, C | 1 |
| Beck-Schimmer, B | 1 |
| Puhan, M | 1 |
| Hao, X | 1 |
| Deng, J | 1 |
| Chen, H | 1 |
| Liu, D | 1 |
| Paredes, D | 1 |
| Silva, JD | 1 |
| Morilak, DA | 2 |
| Shepard, R | 1 |
| Heslin, K | 1 |
| Hagerdorn, P | 1 |
| Coutellier, L | 1 |
| Ide, S | 1 |
| Ikekubo, Y | 1 |
| Mishina, M | 1 |
| Ikeda, K | 1 |
| Ecevitoglu, A | 1 |
| Canbeyli, R | 1 |
| Unal, G | 1 |
| Hołuj, M | 1 |
| Alirezaei, M | 1 |
| Rezaei, M | 1 |
| Hajighahramani, S | 1 |
| Sookhtehzari, A | 1 |
| Kiani, K | 1 |
| Zhang, H | 1 |
| Sun, XR | 1 |
| Wang, J | 1 |
| Zhang, ZZ | 1 |
| Zhao, HT | 1 |
| Li, HH | 1 |
| Ji, MH | 1 |
| Li, KY | 1 |
| Yang, JJ | 1 |
| Patton, MS | 1 |
| Lodge, DJ | 1 |
| Girotti, M | 1 |
| DeMartinis, N | 1 |
| Huguenel, B | 1 |
| Gaudreault, F | 1 |
| Bednar, MM | 1 |
| Shaffer, CL | 1 |
| Gupta, S | 1 |
| Cahill, J | 1 |
| Sherif, MA | 1 |
| Mancuso, J | 1 |
| Zumpano, L | 1 |
| Morgan, CJ | 1 |
| Curran, HV | 1 |
| Jiang, DY | 1 |
| Lu, HW | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Baden PRIDe Trial - Baden Prevention and Reduction of Incidence of Postoperative Delirium Trial[NCT02433041] | Phase 4 | 200 participants (Actual) | Interventional | 2013-07-31 | Completed | ||
| A Randomized, Double-blind, Placebo-controlled, 2-period Crossover Study to Evaluate the Effect of Intranasal Esketamine on Cognitive Functioning in Healthy Subjects[NCT02094378] | Phase 1 | 24 participants (Actual) | Interventional | 2014-06-30 | Completed | ||
| Evaluation of the Antidepressant Effects of Nitrous Oxide in People With Major Depressive Disorder[NCT05357040] | Phase 2 | 172 participants (Anticipated) | Interventional | 2021-06-30 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
8 reviews available for ketamine and Cognitive Decline
| Article | Year |
|---|---|
Ketamine as a pharmacological tool for the preclinical study of memory deficit in schizophrenia.
Topics: Cognitive Dysfunction; Humans; Ketamine; Memory Disorders; Receptors, N-Methyl-D-Aspartate; Schizoph | 2023 |
Ketamine and its metabolites: Potential as novel treatments for depression.
Topics: Cognitive Dysfunction; Depression; Dissociative Disorders; Humans; Ketamine; Psychotherapy | 2023 |
Arketamine for cognitive impairment in psychiatric disorders.
Topics: Animals; Antidepressive Agents; Cognitive Dysfunction; Depressive Disorder, Major; Ketamine; Mice | 2023 |
Effects of anesthetic adjunctive agents on postoperative cognitive dysfunction in elderly patients undergoing noncardiac surgery: A Bayesian network meta-analysis.
Topics: Adjuvants, Anesthesia; Aged; Anesthetics; Bayes Theorem; Cognitive Dysfunction; Dexmedetomidine; Hum | 2023 |
Perioperative ketamine administration to prevent delirium and neurocognitive disorders after surgery: a systematic review and meta-analysis.
Topics: Adult; Aged; Cognition Disorders; Cognitive Dysfunction; Emergence Delirium; Humans; Ketamine; Rando | 2023 |
Pharmacological Agents That Prevent Postoperative Cognitive Dysfunction in Patients With General Anesthesia: A Network Meta-analysis.
Topics: Anesthesia, General; Bayes Theorem; Cognitive Dysfunction; Dexmedetomidine; Humans; Ketamine; Networ | 2020 |
Intraoperative ketamine administration to prevent delirium or postoperative cognitive dysfunction: A systematic review and meta-analysis.
Topics: Anesthetics, Dissociative; Cognitive Dysfunction; Delirium; Humans; Intraoperative Care; Ketamine; P | 2018 |
Ketamine use: a review.
Topics: Abdominal Pain; Acute Disease; Anesthetics, Dissociative; Animals; Behavior, Addictive; Child; Chron | 2012 |
6 trials available for ketamine and Cognitive Decline
| Article | Year |
|---|---|
Ketamine vs. haloperidol for prevention of cognitive dysfunction and postoperative delirium: A phase IV multicentre randomised placebo-controlled double-blind clinical trial.
Topics: Adult; Cognitive Dysfunction; Delirium; Double-Blind Method; Haloperidol; Humans; Ketamine | 2021 |
Subanesthetic dose of ketamine for the antidepressant effects and the associated cognitive impairments of electroconvulsive therapy in elderly patients-A randomized, double-blind, controlled clinical study.
Topics: Aged; Anesthetics, Dissociative; Anesthetics, Intravenous; Antidepressive Agents; Cognitive Dysfunct | 2021 |
Working memory associated with anti-suicidal ideation effect of repeated-dose intravenous ketamine in depressed patients.
Topics: Adult; Antidepressive Agents; Cognitive Dysfunction; Depressive Disorder, Major; Excitatory Amino Ac | 2021 |
Effect of intranasal esketamine on cognitive functioning in healthy participants: a randomized, double-blind, placebo-controlled study.
Topics: Administration, Intranasal; Adult; Cognition; Cognitive Dysfunction; Cross-Over Studies; Dizziness; | 2018 |
Dose-Related Target Occupancy and Effects on Circuitry, Behavior, and Neuroplasticity of the Glycine Transporter-1 Inhibitor PF-03463275 in Healthy and Schizophrenia Subjects.
Topics: Adult; Azabicyclo Compounds; Brain; Cognitive Dysfunction; Dose-Response Relationship, Drug; Double- | 2018 |
Virtual reality-based cognitive training for drug abusers: A randomised controlled trial.
Topics: Adult; Cognitive Dysfunction; Cognitive Remediation; Excitatory Amino Acid Antagonists; Female; Foll | 2020 |
35 other studies available for ketamine and Cognitive Decline
| Article | Year |
|---|---|
Blockade of the NLRP3/caspase-1 axis attenuates ketamine-induced hippocampus pyroptosis and cognitive impairment in neonatal rats.
Topics: Animals; Animals, Newborn; Caspase 1; Caspase Inhibitors; Cognitive Dysfunction; Dipeptides; Excitat | 2021 |
Identification of Molecular Markers of Clozapine Action in Ketamine-Induced Cognitive Impairment: A GPCR Signaling PathwayFinder Study.
Topics: Animals; Biomarkers; Clozapine; Cognitive Dysfunction; Gene Expression Profiling; Gene Expression Re | 2021 |
Comment on:"Ketamine vs haloperidol for prevention of cognitive dysfunction and postoperative delirium: A phase IV multicentre randomised placebo-controlled double-blind clinical trial".
Topics: Cognitive Dysfunction; Delirium; Double-Blind Method; Haloperidol; Humans; Ketamine | 2022 |
Ketamine-Associated Intraoperative Electroencephalographic Signatures of Elderly Patients With and Without Preoperative Cognitive Impairment.
Topics: Aged; Analgesics, Non-Narcotic; Cognitive Dysfunction; Delirium; Electroencephalography; Female; Hum | 2022 |
Risperidone and ethyl pyruvate have protective effects against ketamine-induced cognitive impairments in mice.
Topics: Animals; Antipsychotic Agents; Cognitive Dysfunction; Ketamine; Mice; Pyruvates; Risperidone | 2022 |
Esketamine alleviates postoperative cognitive decline via stimulator of interferon genes/ TANK-binding kinase 1 signaling pathway in aged rats.
Topics: Adaptor Proteins, Signal Transducing; Animals; Cognitive Dysfunction; Hippocampus; Interferons; Keta | 2022 |
Ulinastatin Alleviates Repetitive Ketamine Exposure-Evoked Cognitive Impairment in Adolescent Mice.
Topics: Animals; Anti-Inflammatory Agents; Cognitive Dysfunction; Glycoproteins; Ketamine; Mice | 2022 |
The Nitric Oxide (NO) Donor Molsidomine Counteract Social Withdrawal and Cognition Deficits Induced by Blockade of the NMDA Receptor in the Rat.
Topics: Animals; Clozapine; Cognition; Cognitive Dysfunction; Ketamine; Memory Disorders; Molsidomine; Nitri | 2023 |
Esketamine for resistant depression in older people with cognitive impairment: A case report.
Topics: Aged; Antidepressive Agents; Cognitive Dysfunction; Depression; Depressive Disorder, Treatment-Resis | 2023 |
Recovery of cognitive functioning following abstinence from ketamine.
Topics: Adult; Anxiety; Cognition; Cognitive Dysfunction; Depression; Excitatory Amino Acid Antagonists; Fem | 2019 |
Ketamine exerts neurotoxic effects on the offspring of pregnant rats via the Wnt/β-catenin pathway.
Topics: Analgesics; Animals; beta Catenin; Cognitive Dysfunction; Down-Regulation; Female; Hippocampus; Keta | 2020 |
Sub-anesthetic and anesthetic ketamine produce different long-lasting behavioral phenotypes (24 h post-treatment) via inducing different brain-derived neurotrophic factor (BDNF) expression level in the hippocampus.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Behavior, Animal; Brain-Derived Neurot | 2020 |
Cannabidiol Improves Cognitive Impairment and Reverses Cortical Transcriptional Changes Induced by Ketamine, in Schizophrenia-Like Model in Rats.
Topics: Animals; Antipsychotic Agents; Cannabidiol; Cognitive Dysfunction; Disease Models, Animal; Ketamine; | 2020 |
Desformylflustrabromine, a positive allosteric modulator of α4β2-containing nicotinic acetylcholine receptors, enhances cognition in rats.
Topics: Allosteric Regulation; Animals; Attention; Cognitive Dysfunction; Hydrocarbons, Brominated; Indole A | 2020 |
Long-term potentiation prevents ketamine-induced aberrant neurophysiological dynamics in the hippocampus-prefrontal cortex pathway in vivo.
Topics: Animals; Cognitive Dysfunction; Hippocampus; Ketamine; Long-Term Potentiation; Male; Prefrontal Cort | 2020 |
Neurobehavioral, testicular and erectile impairments of chronic ketamine administration: Pathogenesis and ameliorating effect of N-acetyl cysteine.
Topics: Acetylcysteine; Analgesics; Animals; Antioxidants; Behavior, Animal; Cognitive Dysfunction; Erectile | 2020 |
Genistein attenuates cognitive deficits and neuroapoptosis in hippocampus induced by ketamine exposure in neonatal rats.
Topics: Animals; Animals, Newborn; Apoptosis; Cognitive Dysfunction; Dose-Response Relationship, Drug; Excit | 2021 |
Cognitive impairment in chronic ketamine abusers.
Topics: Adult; Anesthetics, Dissociative; Chronic Disease; Cognitive Dysfunction; Executive Function; Female | 2020 |
Cognitive impairment in ketamine abusers.
Topics: Anesthetics, Dissociative; Cognitive Dysfunction; Humans; Ketamine; Substance-Related Disorders | 2021 |
Long-term neurocognitive dysfunction in offspring via NGF/ ERK/CREB signaling pathway caused by ketamine exposure during the second trimester of pregnancy in rats.
Topics: Animals; Biomarkers; Blood Gas Analysis; Blood Glucose; Cognitive Dysfunction; Cyclic AMP Response E | 2017 |
Prenatal exposure to ketamine in rats: Implications on animal models of schizophrenia.
Topics: Animals; Behavior, Animal; CA3 Region, Hippocampal; Cognitive Dysfunction; Disease Models, Animal; E | 2018 |
Similar psychotic and cognitive profile between ketamine dependence with persistent psychosis and schizophrenia.
Topics: Adult; Cognition; Cognitive Dysfunction; Excitatory Amino Acid Antagonists; Female; Humans; Ketamine | 2018 |
Other drug use does not impact cognitive impairments in chronic ketamine users.
Topics: Adolescent; Adult; Cognition; Cognitive Dysfunction; Executive Function; Female; Humans; Illicit Dru | 2018 |
The profile of cognitive impairments in chronic ketamine users.
Topics: Adult; Cognition; Cognitive Dysfunction; Excitatory Amino Acid Antagonists; Female; Humans; Ketamine | 2018 |
Anesthetics alleviate learning and memory impairment induced by electroconvulsive shock by regulation of NMDA receptor-mediated metaplasticity in depressive rats.
Topics: Anesthetics; Animals; Behavior, Animal; Cognitive Dysfunction; Depression; Disease Models, Animal; E | 2018 |
Ketamine Corrects a Deficit in Reversal Learning Caused by Chronic Intermittent Cold Stress in Female Rats.
Topics: Animals; Behavior, Animal; Cognitive Dysfunction; Disease Models, Animal; Disks Large Homolog 4 Prot | 2018 |
Downregulation of Npas4 in parvalbumin interneurons and cognitive deficits after neonatal NMDA receptor blockade: relevance for schizophrenia.
Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Cognitive Dysfunction; Disease Models, Animal | 2019 |
Cognitive Impairment That Is Induced by (R)-Ketamine Is Abolished in NMDA GluN2D Receptor Subunit Knockout Mice.
Topics: Animals; Antidepressive Agents; Cognitive Dysfunction; Ketamine; Mice, Inbred C57BL; Mice, Knockout; | 2019 |
Oral ketamine alleviates behavioral despair without cognitive impairment in Wistar rats.
Topics: Administration, Oral; Animals; Antidepressive Agents; Behavior, Animal; Brain; Cognitive Dysfunction | 2019 |
The effects of a 5-HT5A receptor antagonist in a ketamine-based rat model of cognitive dysfunction and the negative symptoms of schizophrenia.
Topics: Animals; Choice Behavior; Cognitive Dysfunction; Excitatory Amino Acid Antagonists; Interpersonal Re | 2016 |
Oleuropein attenuates cognitive dysfunction and oxidative stress induced by some anesthetic drugs in the hippocampal area of rats.
Topics: Anesthetics; Animals; Antioxidants; Catalase; Cognitive Dysfunction; Glutathione Peroxidase; Hippoca | 2017 |
Reactive Oxygen Species-mediated Loss of Phenotype of Parvalbumin Interneurons Contributes to Long-term Cognitive Impairments After Repeated Neonatal Ketamine Exposures.
Topics: Acetophenones; Animals; Anxiety; Brain; Cognitive Dysfunction; Cohort Studies; Disease Models, Anima | 2016 |
Ketamine Corrects Stress-Induced Cognitive Dysfunction through JAK2/STAT3 Signaling in the Orbitofrontal Cortex.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Cognitive Dysfunction; Cytoskeletal Proteins; Enzy | 2017 |
Attenuation of ketamine-induced impairment in verbal learning and memory in healthy volunteers by the AMPA receptor potentiator PF-04958242.
Topics: Adult; Cognitive Dysfunction; Double-Blind Method; Female; Healthy Volunteers; Humans; Ketamine; Mal | 2017 |
[Effect of electroacupuncture on the cognitive function and plasma antibodies against beta-amyloid protein in aged rats with ketamine anesthesia].
Topics: Amyloid beta-Peptides; Anesthesia; Animals; Antibodies; Cognitive Dysfunction; Electroacupuncture; F | 2011 |