Page last updated: 2024-10-29

ketamine and Cystitis

ketamine has been researched along with Cystitis in 84 studies

Ketamine: A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.
ketamine : A member of the class of cyclohexanones in which one of the hydrogens at position 2 is substituted by a 2-chlorophenyl group, while the other is substituted by a methylamino group.

Cystitis: Inflammation of the URINARY BLADDER, either from bacterial or non-bacterial causes. Cystitis is usually associated with painful urination (dysuria), increased frequency, urgency, and suprapubic pain.

Research Excerpts

ExcerptRelevanceReference
"Ketamine cystitis (KC) is a chronic bladder inflammation leading to urinary urgency, frequency, and pain."9.12Molecular pathways underlying tissue injuries in the bladder with ketamine cystitis. ( Chen, H; Ergu, E; Huang, R; Liang, J; Luo, C; Qiao, H; Xie, X; Xing, H; Yang, J; Zhou, L, 2021)
"Long-term or recreational use of ketamine affects the urinary system and can result in ketamine-induced cystitis (KIC)."9.12Rodent models of ketamine-induced cystitis. ( Berger, G; Cox, A; Kelly, MEM; Lehmann, C; Sultana, S, 2021)
"Ketamine-related cystitis is characterized by ketamine-induced urinary frequency and bladder pain."8.91Possible pathophysiology of ketamine-related cystitis and associated treatment strategies. ( Hsu, YH; Jhang, JF; Kuo, HC, 2015)
"To determine the diagnosis, treatment, and pathogenesis of ketamine-associated cystitis."8.89[Diagnosis and treatment of ketamine-associated cystitis: a report of 3 cases and literature review]. ( Ding, J; Huang, K; Huang, L; Li, D; Li, Y; Luo, K; Tang, Z; Wang, G; Zhou, J, 2013)
"In this study, using transcriptomic and correlation analyses of metabolomics, we identified pathways that may be potential targets for the prevention and treatment of ketamine-induced bladder fibrosis."8.12Transcriptomic analysis of bladder tissue in a rat model of ketamine-induced bladder fibrosis. ( Li, H; Li, K; Tang, Z; Wang, Z; Zhu, Q, 2022)
"The present study attempted to elucidate whether intravesical instillation of platelet-rich plasma (PRP) could decrease bladder inflammation and ameliorate bladder hyperactivity in ketamine ulcerative cystitis (KIC) rat model."8.12Therapeutic Effect of Platelet-Rich Plasma Improves Bladder Overactivity in the Pathogenesis of Ketamine-Induced Ulcerative Cystitis in a Rat Model. ( Chuang, SM; Chueh, KS; Huang, KH; Juan, TJ; Juan, YS; Lee, YC; Lin, RJ; Long, CY; Lu, JH; Shen, MC; Sun, TW, 2022)
"Stronger contractility and smaller bladder capacity are common symptoms in ketamine cystitis (KC)."8.02Smaller bladder capacity and stronger bladder contractility in patients with ketamine cystitis are associated with elevated TRPV1 and TRPV4. ( Hsu, YH; Jhang, JF; Jiang, YH; Kuo, HC; Yang, HH; Zhai, WJ, 2021)
"Long-term abuse of ketamine causes ketamine-induced cystitis."7.96Extracellular vesicles enhance oxidative stress through P38/NF-kB pathway in ketamine-induced ulcerative cystitis. ( Chen, SH; He, PJ; Jiang, ZW; Lu, Y; Mi, H; Xi, XJ; Zeng, JJ, 2020)
"To investigate the mechanism of bladder nerve hyperplasia and fibrosis in the patients with ketamine-associated cystitis (KC)."7.91Upregulation of neurotrophins and transforming growth factor-β expression in the bladder may lead to nerve hyperplasia and fibrosis in patients with severe ketamine-associated cystitis. ( Birder, LA; Hsu, YH; Jhang, JF; Kuo, HC; Wang, HJ, 2019)
"We investigated the effects of Ba-Wei-Die-Huang-Wan (BWDHW) on ketamine-induced cystitis (KIC) in a rat model."7.91Ba-Wei-Die-Huang-Wan (Hachimi-jio-gan) can ameliorate ketamine-induced cystitis by modulating neuroreceptors, inflammatory mediators, and fibrogenesis in a rat model. ( Chuang, YC; Lee, WC; Su, CH; Tain, YL; Tsai, CN; Yu, CC, 2019)
"The present study investigated the methylation of CpG sites in the cyclooxygenase (COX)‑2 promoter via nuclear factor (NF)‑κB transcriptional regulation and elucidated its effect on the COX‑2 transcriptional expression in a ketamine‑induced ulcerative cystitis (KIC) animal model."7.91Epigenetic regulation of COX‑2 expression by DNA hypomethylation via NF‑κB activation in ketamine‑induced ulcerative cystitis. ( Chuang, SM; Hsiao, HP; Juan, YS; Lee, YC; Lin, KL; Long, CY; Lu, JH; Tsai, CC; Wu, WJ; Yang, HJ, 2019)
"Ketamine abusers may develop ulcerative cystitis and severe lower urinary tract symptoms, which is a medical dilemma."7.88Potential Orphan Drug Therapy of Intravesical Liposomal Onabotulinumtoxin-A for Ketamine-Induced Cystitis by Mucosal Protection and Anti-inflammation in a Rat Model. ( Chuang, YC; Lee, WC; Su, CH; Tain, YL; Tsai, CN; Yu, CC, 2018)
"Ketamine abuse is an emerging issue in many countries, and ketamine cystitis (KC) is a growing disease which more and more urologists may encounter with."7.88Complete reversal of the clinical symptoms and image morphology of ketamine cystitis after intravesical hyaluronic acid instillation: A case report. ( Cha, TL; Liu, CY; Ou, YL; Tsao, CW; Wu, ST, 2018)
"Ketamine-induced ulcerative cystitis (KIC) initially damaged the bladder mucosa and induced contracted bladder thereafter."7.85Elucidating Mechanisms of Bladder Repair after Hyaluronan Instillation in Ketamine-Induced Ulcerative Cystitis in Animal Model. ( Chuang, SM; Ho, WT; Juan, YS; Lee, YC; Lee, YL; Lin, KL; Lu, MC; Wu, BN; Wu, WJ; Yuan, SF, 2017)
"Ketamine-induced cystitis (KC) among chronic ketamine young abusers has increased dramatically and it has brought attention for Urologists."7.85The putative involvement of actin-binding proteins and cytoskeleton proteins in pathological mechanisms of ketamine cystitis-Revealed by a prospective pilot study using proteomic approaches. ( Kuo, HC; Yang, HH; Zhai, WJ, 2017)
"Bladder wall fibrosis is a major complication of ketamine-induced cystitis (KC), but the underlying pathogenesis is poorly understood."7.85Ketamine-induced bladder fibrosis involves epithelial-to-mesenchymal transition mediated by transforming growth factor-β1. ( Chen, J; Chen, Y; Gu, D; Wang, J; Wu, P; Zhang, G; Zhao, J, 2017)
"Objective Ketamine-associated cystitis (KAC) has been described in a few case reports, but its treatment in a relatively large number of patients has not been documented."7.85Effective treatment of ketamine-associated cystitis with botulinum toxin type a injection combined with bladder hydrodistention. ( Huang, Z; Lai, H; Wang, S; Wei, L; Zeng, J; Zheng, D; Zhong, L; Zou, W, 2017)
"Abuse of the hallucinogenic drug ketamine promotes the development of lower urinary tract symptoms that resemble interstitial cystitis."7.83Mesenchymal stem cells protect against the tissue fibrosis of ketamine-induced cystitis in rat bladder. ( Choi, SJ; Choo, MS; Heo, J; Kim, A; Kim, SW; Kim, Y; Lee, S; Lim, J; Oh, W; Shin, DM; Shin, JH; Song, M; Yoon, SJ; Yu, HY, 2016)
"To establish whether the urothelial ulceration observed in ketamine-induced cystitis is triggered by urinary or systemic factors."7.83A Rare Urachal Cyst in a Case of Ketamine-induced Cystitis Provides Mechanistic Insights. ( Baker, SC; Fulford, S; Garthwaite, M; Kidger, E; Southgate, J; Stahlschmidt, J, 2016)
"The aim of the current study was to evaluate the histopathological features of inflammation and the expression levels of inflammatory markers in tissue samples from patients with ketamine‑induced cystitis."7.81Histopathological assessment of inflammation and expression of inflammatory markers in patients with ketamine-induced cystitis. ( Cha, TL; Chiueh, TS; Lee, HS; Lin, HA; Lin, HC; Lin, YC; Meng, E, 2015)
"Long-term ketamine abuse is known to affect the lower urinary tract and produce symptoms of cystitis."7.80Long-term ketamine abuse induces cystitis in rats by impairing the bladder epithelial barrier. ( Gu, D; Huang, J; Shan, Z; Wu, P; Yin, Y; Zheng, S, 2014)
"Ketamine cystitis is a complex problem whose exact pathological mechanism and natural history remain unknown."7.80Ketamine cystitis: practical considerations in management. ( Chetwood, A; Coker, C; Misra, S; Thomas, P, 2014)
"The histological findings were distinguishing features of ketamine cystitis and were not present in other painful bladder conditions."7.79Nerve hyperplasia: a unique feature of ketamine cystitis. ( Baker, SC; Eardley, I; Fulford, S; Gillatt, D; Hinley, J; Marsh, F; Oxley, J; Southgate, J; Stahlschmidt, J, 2013)
"The aims of the present study were to investigate voiding patterns, tissue constituents and the expressions of cyclooxygenase-2 (COX-2) and nitric oxide synthase (NOS) involved in ketamine-induced ulcerative cystitis in rat urinary bladder."7.79Dual involvements of cyclooxygenase and nitric oxide synthase expressions in ketamine-induced ulcerative cystitis in rat bladder. ( Chang, WC; Chuang, SM; Jang, MY; Juan, YS; Lee, HH; Levin, RM; Li, YL; Liu, KM; Wu, WJ, 2013)
"Ketamine can lead to reactive urothelial changes that can mimic carcinoma in situ, but the long-term cancer risk remains unknown."7.75Ketamine cystitis as a mimic of carcinoma in situ. ( Adams, S; Cottrell, AM; Gillatt, D; Oxley, JD, 2009)
"This case series has described a new clinical entity of severe ulcerative cystitis as a result of chronic ketamine use."7.74Ketamine-associated ulcerative cystitis: a new clinical entity. ( Dickson, B; Shahani, R; Stewart, RJ; Streutker, C, 2007)
"Ketamine is a dissociative anesthetic, historically used in a clinical setting for the induction and maintenance of anesthesia."7.01Current approaches for the treatment of ketamine-induced cystitis. ( Lehmann, C; Miab, ZR; Scott, C; Zhou, J, 2023)
"Ketamine is a versatile analgesic that has become an increasingly popular recreational drug."5.62Recreational ketamine-induced cholangiopathy and ulcerative cystitis. ( Freyre, K; Opsha, O; Opsha, Y; Vu, DM, 2021)
"Ketamine is an ionotropic glutamatergic N‑methyl‑D‑aspartate receptor antagonist, which is widely used among recreational drug abusers."5.48Clinical significance of interleukin‑6 and inducible nitric oxide synthase in ketamine‑induced cystitis. ( Chen, SK; Chien, CC; Huang, CJ; Lee, FK; Wang, YC; Wu, ST, 2018)
"Ketamine abuse has become a global phenomenon in recent years."5.46Clinical Outcome of Augmentation Enterocystoplasty for Patients with Ketamine-induced Cystitis. ( Jhang, JF; Kuo, HC; Lee, YK, 2017)
"Ketamine-treated rats were found to display bladder hyperactivity."5.42Ketamine-induced ulcerative cystitis and bladder apoptosis involve oxidative stress mediated by mitochondria and the endoplasmic reticulum. ( Chuang, SM; Ho, WT; Jang, MY; Juan, YS; Lee, YL; Lin, RJ; Liu, KM; Long, CY; Lu, JH; Lu, MC; Wang, CC; Wu, WJ, 2015)
"Treatment with ketamine + COX-2 inhibitor prevented these bladder dysfunctions."5.42Translocation of NF-κB and expression of cyclooxygenase-2 are enhanced by ketamine-induced ulcerative cystitis in rat bladder. ( Chang, WC; Chuang, SM; Huang, YS; Jang, MY; Juan, YS; Lee, YL; Long, CY; Lu, JH; Wong, JH; Wu, WJ, 2015)
"The ketamine usage pattern was recorded: initiation, administration route, dose in the last month and frequency of usage."5.38[Cystitis and ketamine associated bladder dysfunction]. ( Arango, O; Bielsa, O; Castillo, C; García-Larrosa, A; Lorente, JA; Ventura, M, 2012)
"Ketamine-associated uropathy frequently involves frequency, urgency, and suprapubic pain; upper urinary tract involvement is less common."5.22Systematic review and meta-analysis of ketamine-associated uropathy. ( Chan, EOT; Chan, VWS; Cheung, V; Ng, CF; Tang, TST; Teoh, JYC; Wong, MCS; Yee, CH, 2022)
"Ketamine-related cystitis is characterized by ketamine-induced urinary frequency and bladder pain."4.91Possible pathophysiology of ketamine-related cystitis and associated treatment strategies. ( Hsu, YH; Jhang, JF; Kuo, HC, 2015)
"To determine the diagnosis, treatment, and pathogenesis of ketamine-associated cystitis."4.89[Diagnosis and treatment of ketamine-associated cystitis: a report of 3 cases and literature review]. ( Ding, J; Huang, K; Huang, L; Li, D; Li, Y; Luo, K; Tang, Z; Wang, G; Zhou, J, 2013)
"The implications of these findings are drawn out for treatment of ketamine-induced ulcerative cystitis in which interventions from urologists and from addiction specialists should be coordinated."4.88Ketamine use: a review. ( Curran, HV; Morgan, CJ, 2012)
"The present study attempted to elucidate whether intravesical instillation of platelet-rich plasma (PRP) could decrease bladder inflammation and ameliorate bladder hyperactivity in ketamine ulcerative cystitis (KIC) rat model."4.12Therapeutic Effect of Platelet-Rich Plasma Improves Bladder Overactivity in the Pathogenesis of Ketamine-Induced Ulcerative Cystitis in a Rat Model. ( Chuang, SM; Chueh, KS; Huang, KH; Juan, TJ; Juan, YS; Lee, YC; Lin, RJ; Long, CY; Lu, JH; Shen, MC; Sun, TW, 2022)
"In this study, using transcriptomic and correlation analyses of metabolomics, we identified pathways that may be potential targets for the prevention and treatment of ketamine-induced bladder fibrosis."4.12Transcriptomic analysis of bladder tissue in a rat model of ketamine-induced bladder fibrosis. ( Li, H; Li, K; Tang, Z; Wang, Z; Zhu, Q, 2022)
"Background Ketamine-related cystitis (KC) has been researched in many clinical studies, but its exact mechanism is ambiguous and needs further research."4.02Ketamine enhances autophagy and endoplasmic reticulum stress in rats and SV-HUC-1 cells via activating IRE1-TRAF2-ASK1-JNK pathway. ( Li, Y; Qiao, H; Shan, Z; Wu, D; Yu, Y, 2021)
"Long-term abuse of ketamine causes ketamine-induced cystitis."3.96Extracellular vesicles enhance oxidative stress through P38/NF-kB pathway in ketamine-induced ulcerative cystitis. ( Chen, SH; He, PJ; Jiang, ZW; Lu, Y; Mi, H; Xi, XJ; Zeng, JJ, 2020)
"To investigate the mechanism of bladder nerve hyperplasia and fibrosis in the patients with ketamine-associated cystitis (KC)."3.91Upregulation of neurotrophins and transforming growth factor-β expression in the bladder may lead to nerve hyperplasia and fibrosis in patients with severe ketamine-associated cystitis. ( Birder, LA; Hsu, YH; Jhang, JF; Kuo, HC; Wang, HJ, 2019)
"We investigated the effects of Ba-Wei-Die-Huang-Wan (BWDHW) on ketamine-induced cystitis (KIC) in a rat model."3.91Ba-Wei-Die-Huang-Wan (Hachimi-jio-gan) can ameliorate ketamine-induced cystitis by modulating neuroreceptors, inflammatory mediators, and fibrogenesis in a rat model. ( Chuang, YC; Lee, WC; Su, CH; Tain, YL; Tsai, CN; Yu, CC, 2019)
"Many clinical studies have been conducted on ketamine-associated cystitis."3.91Ketamine induces endoplasmic reticulum stress in rats and SV-HUC-1 human uroepithelial cells by activating NLRP3/TXNIP aix. ( Cui, L; Guo, W; Jiang, X; Li, D; Ma, Y; Shan, Z; Wan, F; Yu, S; Zhang, C, 2019)
"The present study investigated the methylation of CpG sites in the cyclooxygenase (COX)‑2 promoter via nuclear factor (NF)‑κB transcriptional regulation and elucidated its effect on the COX‑2 transcriptional expression in a ketamine‑induced ulcerative cystitis (KIC) animal model."3.91Epigenetic regulation of COX‑2 expression by DNA hypomethylation via NF‑κB activation in ketamine‑induced ulcerative cystitis. ( Chuang, SM; Hsiao, HP; Juan, YS; Lee, YC; Lin, KL; Long, CY; Lu, JH; Tsai, CC; Wu, WJ; Yang, HJ, 2019)
"Ketamine abuse is an emerging issue in many countries, and ketamine cystitis (KC) is a growing disease which more and more urologists may encounter with."3.88Complete reversal of the clinical symptoms and image morphology of ketamine cystitis after intravesical hyaluronic acid instillation: A case report. ( Cha, TL; Liu, CY; Ou, YL; Tsao, CW; Wu, ST, 2018)
"Twenty-three patients with ketamine-induced cystitis (KC) and 16 control volunteers were recruited."3.85Activation of the mTOR dependent signaling pathway underlies ketamine-induced uropathy. ( Lin, AT; Lin, CC; Yang, AH, 2017)
"Bladder wall fibrosis is a major complication of ketamine-induced cystitis (KC), but the underlying pathogenesis is poorly understood."3.85Ketamine-induced bladder fibrosis involves epithelial-to-mesenchymal transition mediated by transforming growth factor-β1. ( Chen, J; Chen, Y; Gu, D; Wang, J; Wu, P; Zhang, G; Zhao, J, 2017)
"Ketamine-induced ulcerative cystitis (KIC) initially damaged the bladder mucosa and induced contracted bladder thereafter."3.85Elucidating Mechanisms of Bladder Repair after Hyaluronan Instillation in Ketamine-Induced Ulcerative Cystitis in Animal Model. ( Chuang, SM; Ho, WT; Juan, YS; Lee, YC; Lee, YL; Lin, KL; Lu, MC; Wu, BN; Wu, WJ; Yuan, SF, 2017)
"Abuse of the hallucinogenic drug ketamine promotes the development of lower urinary tract symptoms that resemble interstitial cystitis."3.83Mesenchymal stem cells protect against the tissue fibrosis of ketamine-induced cystitis in rat bladder. ( Choi, SJ; Choo, MS; Heo, J; Kim, A; Kim, SW; Kim, Y; Lee, S; Lim, J; Oh, W; Shin, DM; Shin, JH; Song, M; Yoon, SJ; Yu, HY, 2016)
"To establish whether the urothelial ulceration observed in ketamine-induced cystitis is triggered by urinary or systemic factors."3.83A Rare Urachal Cyst in a Case of Ketamine-induced Cystitis Provides Mechanistic Insights. ( Baker, SC; Fulford, S; Garthwaite, M; Kidger, E; Southgate, J; Stahlschmidt, J, 2016)
"Recreational abuse of ketamine has been associated with the emergence of a new bladder pain syndrome, ketamine-induced cystitis, characterized by chronic inflammation and urothelial ulceration."3.83Ketamine-Induced Apoptosis in Normal Human Urothelial Cells: A Direct, N-Methyl-d-Aspartate Receptor-Independent Pathway Characterized by Mitochondrial Stress. ( Baker, SC; Georgopoulos, NT; Shabir, S; Southgate, J, 2016)
"Ketamine-associated cystitis is a well-recognised syndrome; yet upper urinary tract involvement remains poorly understood."3.81Autotransplantation for the management of ketamine ureteritis. ( Game, D; O'Brien, T; Olsburgh, J; Raison, NT, 2015)
"Ketamine cystitis is a complex problem whose exact pathological mechanism and natural history remain unknown."3.80Ketamine cystitis: practical considerations in management. ( Chetwood, A; Coker, C; Misra, S; Thomas, P, 2014)
"To report our early results of augmentation enterocystoplasty (AE) for severe bladder pain associated with chronic ketamine cystitis (KC)."3.80Augmentation enterocystoplasty is effective in relieving refractory ketamine-related bladder pain. ( Chung, SD; Kuo, HC; Wang, CC, 2014)
"Long-term ketamine abuse is known to affect the lower urinary tract and produce symptoms of cystitis."3.80Long-term ketamine abuse induces cystitis in rats by impairing the bladder epithelial barrier. ( Gu, D; Huang, J; Shan, Z; Wu, P; Yin, Y; Zheng, S, 2014)
"The histological findings were distinguishing features of ketamine cystitis and were not present in other painful bladder conditions."3.79Nerve hyperplasia: a unique feature of ketamine cystitis. ( Baker, SC; Eardley, I; Fulford, S; Gillatt, D; Hinley, J; Marsh, F; Oxley, J; Southgate, J; Stahlschmidt, J, 2013)
"Long-term ketamine abuse induces phosphorylation of transgelin in the bladder wall, and this might play an important role in the pathogenesis of ketamine-associated cystitis."3.79Effects of long-term ketamine administration on rat bladder protein levels: a proteomic investigation using two-dimensional difference gel electrophoresis system. ( Gu, D; Huang, J; Shan, Z; Wu, P; Yin, Y; Zheng, S, 2013)
" What's known on the subject? and What does the study add? Case series have described lower urinary tract symptoms associated with ketamine use including severe pain, frequency, haematuria and dysuria."3.78The prevalence and natural history of urinary symptoms among recreational ketamine users. ( Cottrell, AM; Gillatt, DA; Mitcheson, L; Winstock, AR, 2012)
"Ketamine can lead to reactive urothelial changes that can mimic carcinoma in situ, but the long-term cancer risk remains unknown."3.75Ketamine cystitis as a mimic of carcinoma in situ. ( Adams, S; Cottrell, AM; Gillatt, D; Oxley, JD, 2009)
"This case series has described a new clinical entity of severe ulcerative cystitis as a result of chronic ketamine use."3.74Ketamine-associated ulcerative cystitis: a new clinical entity. ( Dickson, B; Shahani, R; Stewart, RJ; Streutker, C, 2007)
") administration of 200mg/kg cyclophosphamide, an antitumoral agent, modified the behaviour of rats with cystitis induced by acrolein, a toxic urinary by-product of cyclophosphamide."3.71Involvement of N-methyl-D-aspartate receptors in nociception in the cyclophosphamide-induced vesical pain model in the conscious rat. ( Boucher, M; Coudoré-Civiale, MA; Eschalier, A; Méen, M; Parry, L, 2002)
"Ketamine is a dissociative anesthetic, historically used in a clinical setting for the induction and maintenance of anesthesia."3.01Current approaches for the treatment of ketamine-induced cystitis. ( Lehmann, C; Miab, ZR; Scott, C; Zhou, J, 2023)
"Ketamine is a general anesthetic."2.66What urologists need to know about ketamine-induced uropathy: A systematic review. ( Castellani, D; Dellabella, M; Gregori, A; Gubbiotti, M; Gudaru, K; Pirola, GM; Rubilotta, E, 2020)
"Ketamine is a versatile analgesic that has become an increasingly popular recreational drug."1.62Recreational ketamine-induced cholangiopathy and ulcerative cystitis. ( Freyre, K; Opsha, O; Opsha, Y; Vu, DM, 2021)
"Ketamine abuse has become a global phenomenon in recent years."1.46Clinical Outcome of Augmentation Enterocystoplasty for Patients with Ketamine-induced Cystitis. ( Jhang, JF; Kuo, HC; Lee, YK, 2017)
"Ketamine abuse causes lower urinary tract symptoms, with the underlying pathophysiology poorly understood."1.43Intact urothelial barrier function in a mouse model of ketamine-induced voiding dysfunction. ( MacIver, B; Ong, TA; Rajandram, R; Razack, AH; Yu, W; Zeidel, M, 2016)
"Ketamine is a short-acting anaesthetic agent that has gained popularity as a 'club drug' due to its hallucinogenic effects."1.42The clinical presentation and diagnosis of ketamine-associated urinary tract dysfunction in Singapore. ( Aydin, H; Kuo, T; Ng, LG; Sundaram, P; Yek, J, 2015)
"Ketamine-treated rats were found to display bladder hyperactivity."1.42Ketamine-induced ulcerative cystitis and bladder apoptosis involve oxidative stress mediated by mitochondria and the endoplasmic reticulum. ( Chuang, SM; Ho, WT; Jang, MY; Juan, YS; Lee, YL; Lin, RJ; Liu, KM; Long, CY; Lu, JH; Lu, MC; Wang, CC; Wu, WJ, 2015)
"Ketamine bladder is a new clinical entity that may lead to irreversible damage to the urinary system."1.38Illicit ketamine and its bladder consequences: is it irreversible? ( Gupta, S; Jalil, R, 2012)
"The ketamine usage pattern was recorded: initiation, administration route, dose in the last month and frequency of usage."1.38[Cystitis and ketamine associated bladder dysfunction]. ( Arango, O; Bielsa, O; Castillo, C; García-Larrosa, A; Lorente, JA; Ventura, M, 2012)

Research

Studies (84)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's8 (9.52)29.6817
2010's58 (69.05)24.3611
2020's18 (21.43)2.80

Authors

AuthorsStudies
Yu, W4
Kutscher, E1
Greene, RE1
Li, H1
Li, K1
Zhu, Q1
Tang, Z3
Wang, Z2
Chung, SD2
Praveen Rajneesh, C1
Chen, KC1
Tai, HC1
Chang, ML1
Tseng, XW1
Cheng, JH1
Tsai, WK1
Chiang, HS1
Wu, YN1
Tan, S1
Zhang, L1
Wang, G2
Zhu, X1
Chueh, KS1
Huang, KH1
Lu, JH4
Juan, TJ1
Chuang, SM6
Lin, RJ2
Lee, YC3
Long, CY4
Shen, MC1
Sun, TW1
Juan, YS6
Chan, EOT3
Chan, VWS3
Tang, TST3
Cheung, V3
Wong, MCS3
Yee, CH4
Ng, CF5
Teoh, JYC3
Zhou, J2
Scott, C1
Miab, ZR1
Lehmann, C2
Jhang, JF6
Wang, HJ1
Hsu, YH4
Birder, LA2
Kuo, HC8
Lee, WC2
Tain, YL2
Chuang, YC2
Tsai, CN2
Yu, CC2
Su, CH2
Cui, L1
Jiang, X1
Zhang, C1
Li, D2
Yu, S1
Wan, F1
Ma, Y1
Guo, W1
Shan, Z4
Castellani, D1
Pirola, GM1
Gubbiotti, M1
Rubilotta, E1
Gudaru, K1
Gregori, A1
Dellabella, M1
Xi, XJ1
Zeng, JJ1
Lu, Y1
Chen, SH1
Jiang, ZW1
He, PJ1
Mi, H1
Chen, H2
Vandorpe, DH1
Xie, X2
Alper, SL1
Zeidel, ML1
Ou, SH1
Wu, LY1
Chen, HY1
Huang, CW1
Hsu, CY1
Chen, CL1
Chou, KJ1
Fang, HC1
Lee, PT1
Hartjes, A1
Hofer, M1
Marlin, D1
Hohenauer, P1
Vu, DM1
Freyre, K1
Opsha, O1
Opsha, Y1
Yang, HH2
Jiang, YH1
Zhai, WJ2
Liang, J1
Huang, R1
Luo, C1
Yang, J2
Xing, H1
Zhou, L1
Qiao, H2
Ergu, E1
Sultana, S1
Berger, G1
Cox, A1
Kelly, MEM1
Yu, Y1
Wu, D1
Li, Y2
Wang, J1
Chen, Y1
Gu, D3
Zhang, G1
Chen, J1
Zhao, J1
Wu, P3
Lee, YK1
Zeng, J1
Lai, H1
Zheng, D1
Zhong, L1
Huang, Z1
Wang, S1
Zou, W1
Wei, L1
Lee, YL3
Lin, KL2
Lu, MC2
Wu, BN1
Wu, WJ5
Yuan, SF1
Ho, WT2
Huang, CJ1
Lee, FK1
Chen, SK1
Chien, CC1
Wu, ST2
Wang, YC1
Sihra, N1
Ockrim, J1
Wood, D2
Chen, YC3
Ou, YL1
Liu, CY1
Cha, TL2
Tsao, CW1
Hsiao, HP1
Tsai, CC1
Yang, HJ1
Wei, YB1
Yang, JR1
Cote, AL1
Rolland, B1
Cottencin, O1
Wang, CC2
Huang, L1
Ding, J1
Luo, K1
Huang, K1
Baker, SC3
Stahlschmidt, J2
Oxley, J1
Hinley, J1
Eardley, I1
Marsh, F1
Gillatt, D2
Fulford, S2
Southgate, J3
García-Larrosa, A2
Capdevila, S1
Laborda, A1
Vargas, C1
Connors, NJ1
Grino, A1
Tunik, MG1
Hoffman, RS1
Misra, S1
Chetwood, A1
Coker, C1
Thomas, P1
Tran, VH1
Nelson, M1
Nogar, J1
Bramante, RM1
Huang, J2
Yin, Y2
Zheng, S2
Lin, HC1
Lee, HS1
Chiueh, TS1
Lin, YC2
Lin, HA1
Meng, E1
Raison, NT1
O'Brien, T1
Game, D1
Olsburgh, J1
Wong, JH1
Jang, MY3
Huang, YS1
Chang, WC2
Liu, KM2
Lai, PT1
Lee, WM1
Tam, YH1
Song, M2
Yu, HY2
Chun, JY1
Shin, DM2
Song, SH1
Choo, MS2
Song, YS1
Wein, AJ1
Yek, J1
Sundaram, P1
Aydin, H1
Kuo, T1
Ng, LG1
Kidger, E1
Garthwaite, M1
Schaeffer, EM1
Rajandram, R1
Ong, TA1
Razack, AH1
MacIver, B1
Zeidel, M1
Chancellor, MB1
Shabir, S1
Georgopoulos, NT1
Kim, A1
Heo, J1
Shin, JH1
Lim, J1
Yoon, SJ1
Kim, Y1
Lee, S1
Kim, SW1
Oh, W1
Choi, SJ1
Wang, L1
Liu, LF1
Huang, YM1
Tang, ZY1
Myers, FA1
Bluth, MH1
Cheung, WW1
Lee, KW1
Kim, WB1
Lee, SW1
Kim, JH1
Kim, JM1
Kim, YH1
Kim, ME1
Lin, CC1
Yang, AH1
Lin, AT1
Hoskins, R1
Chen, LY1
Chen, KP1
Huang, MC1
Oxley, JD2
Cottrell, AM3
Adams, S1
Hopcroft, SA1
Mason, K1
Abrams, P1
Morgan, CJ1
Curran, HV1
Chen, YL1
Huang, GS1
Wu, CJ1
Castillo, C1
Ventura, M1
Lorente, JA1
Bielsa, O1
Arango, O1
Lieb, M1
Bader, M1
Palm, U1
Stief, CG1
Baghai, TC1
Chen, CH1
Lee, MH1
Lin, MF1
Winstock, AR1
Mitcheson, L1
Gillatt, DA1
Wei, Y1
Song, W1
Guo, Q1
Jalil, R1
Gupta, S1
Gray, T1
Dass, M1
Li, YL1
Lee, HH1
Levin, RM1
Méen, M1
Coudoré-Civiale, MA1
Parry, L1
Eschalier, A1
Boucher, M1
Shahani, R2
Streutker, C1
Dickson, B1
Stewart, RJ2
Grégoire, MC1
MacLellan, DL1
Finley, GA1
Wood, R1
Eichel, L1
Messing, EM1
Schwarz, E1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Evaluation of the Antidepressant Effects of Nitrous Oxide in People With Major Depressive Disorder[NCT05357040]Phase 2172 participants (Anticipated)Interventional2021-06-30Recruiting
Intravesical Injection of Dextrose to Improve Lower Urinary Tract Symptoms Caused by Chronic Cystitis[NCT04821882]29 participants (Actual)Interventional2019-05-01Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

12 reviews available for ketamine and Cystitis

ArticleYear
Reviving Cav1.2 as an attractive drug target to treat bladder dysfunction.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2022, Volume: 36, Issue:1

    Topics: Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Cystitis; Drug Delivery Systems; Humans

2022
Systematic review and meta-analysis of ketamine-associated uropathy.
    Hong Kong medical journal = Xianggang yi xue za zhi, 2022, Volume: 28, Issue:6

    Topics: Cystitis; Humans; Ketamine; Pain; Urinary Bladder; Urologic Diseases

2022
Systematic review and meta-analysis of ketamine-associated uropathy.
    Hong Kong medical journal = Xianggang yi xue za zhi, 2022, Volume: 28, Issue:6

    Topics: Cystitis; Humans; Ketamine; Pain; Urinary Bladder; Urologic Diseases

2022
Systematic review and meta-analysis of ketamine-associated uropathy.
    Hong Kong medical journal = Xianggang yi xue za zhi, 2022, Volume: 28, Issue:6

    Topics: Cystitis; Humans; Ketamine; Pain; Urinary Bladder; Urologic Diseases

2022
Systematic review and meta-analysis of ketamine-associated uropathy.
    Hong Kong medical journal = Xianggang yi xue za zhi, 2022, Volume: 28, Issue:6

    Topics: Cystitis; Humans; Ketamine; Pain; Urinary Bladder; Urologic Diseases

2022
Current approaches for the treatment of ketamine-induced cystitis.
    Neurourology and urodynamics, 2023, Volume: 42, Issue:3

    Topics: Administration, Intravesical; Animals; Cystitis; Ketamine; Substance-Related Disorders

2023
What urologists need to know about ketamine-induced uropathy: A systematic review.
    Neurourology and urodynamics, 2020, Volume: 39, Issue:4

    Topics: Analgesics; Cystitis; Cystoscopy; Diagnosis, Differential; Humans; Ketamine; Substance-Related Disor

2020
Molecular pathways underlying tissue injuries in the bladder with ketamine cystitis.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2021, Volume: 35, Issue:7

    Topics: Cystitis; Gene Expression Regulation; Humans; Ketamine; Signal Transduction; Urinary Bladder

2021
Rodent models of ketamine-induced cystitis.
    Neurourology and urodynamics, 2021, Volume: 40, Issue:7

    Topics: Animals; Cystitis; Ketamine; Rodentia

2021
[Diagnosis and treatment of ketamine-associated cystitis: a report of 3 cases and literature review].
    Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2013, Volume: 38, Issue:9

    Topics: Biopsy; Cystitis; Cystoscopy; Humans; Ketamine; Lower Urinary Tract Symptoms; Recurrence; Retrospect

2013
Possible pathophysiology of ketamine-related cystitis and associated treatment strategies.
    International journal of urology : official journal of the Japanese Urological Association, 2015, Volume: 22, Issue:9

    Topics: Acetylcholine Release Inhibitors; Anesthetics, Dissociative; Anti-Inflammatory Agents, Non-Steroidal

2015
Ketamine: A Cause of Urinary Tract Dysfunction.
    Clinics in laboratory medicine, 2016, Volume: 36, Issue:4

    Topics: Analgesics; Cystitis; Diagnosis, Differential; Female; Humans; Ketamine; Lower Urinary Tract Symptom

2016
Ketamine use: a review.
    Addiction (Abingdon, England), 2012, Volume: 107, Issue:1

    Topics: Abdominal Pain; Acute Disease; Anesthetics, Dissociative; Animals; Behavior, Addictive; Child; Chron

2012
Ketamine-snorting associated cystitis.
    Journal of the Formosan Medical Association = Taiwan yi zhi, 2011, Volume: 110, Issue:12

    Topics: Adult; Cystitis; Female; Humans; Ketamine; Male; Substance-Related Disorders; Young Adult

2011
Ketamine cystitis: an emerging diagnostic and therapeutic challenge.
    British journal of hospital medicine (London, England : 2005), 2012, Volume: 73, Issue:10

    Topics: Cystitis; Diagnosis, Differential; Excitatory Amino Acid Antagonists; Humans; Illicit Drugs; Ketamin

2012

Other Studies

72 other studies available for ketamine and Cystitis

ArticleYear
Ketamine Cystitis: An Underrecognized Cause of Dysuria.
    Journal of general internal medicine, 2022, Volume: 37, Issue:5

    Topics: Cystitis; Dysuria; Humans; Ketamine; Substance-Related Disorders

2022
Transcriptomic analysis of bladder tissue in a rat model of ketamine-induced bladder fibrosis.
    Neurourology and urodynamics, 2022, Volume: 41, Issue:3

    Topics: Animals; Cystitis; Female; Fibrosis; Gene Expression Profiling; Humans; Ketamine; Male; Rats; Rats,

2022
Specific Impacts of Ketamine on Bladder Dysfunction and Associated Histological Alterations in Rats-A Time Course Validation through Transmission Electron Microscopy.
    International journal of molecular sciences, 2022, Feb-16, Volume: 23, Issue:4

    Topics: Animals; Cystitis; Hypertrophy; Ketamine; Microscopy, Electron, Transmission; Rats; Rats, Sprague-Da

2022
Intravesical hyaluronic acid therapy after bladder autoaugmentation by transurethral vesicomyotomy for ketamine cystitis: is it helpful?
    World journal of urology, 2022, Volume: 40, Issue:6

    Topics: Administration, Intravesical; Cystitis; Cystitis, Interstitial; Humans; Hyaluronic Acid; Ketamine; U

2022
Therapeutic Effect of Platelet-Rich Plasma Improves Bladder Overactivity in the Pathogenesis of Ketamine-Induced Ulcerative Cystitis in a Rat Model.
    International journal of molecular sciences, 2022, May-21, Volume: 23, Issue:10

    Topics: Animals; Cystitis; Female; Humans; Ketamine; Platelet-Rich Plasma; Psychomotor Agitation; Rats; Rats

2022
Upregulation of neurotrophins and transforming growth factor-β expression in the bladder may lead to nerve hyperplasia and fibrosis in patients with severe ketamine-associated cystitis.
    Neurourology and urodynamics, 2019, Volume: 38, Issue:8

    Topics: Adult; Aged; Brain-Derived Neurotrophic Factor; Cystitis; Excitatory Amino Acid Antagonists; Female;

2019
Ba-Wei-Die-Huang-Wan (Hachimi-jio-gan) can ameliorate ketamine-induced cystitis by modulating neuroreceptors, inflammatory mediators, and fibrogenesis in a rat model.
    Neurourology and urodynamics, 2019, Volume: 38, Issue:8

    Topics: Animals; Collagen; Cyclooxygenase 2; Cystitis; Drugs, Chinese Herbal; Female; Fibronectins; Function

2019
Ketamine induces endoplasmic reticulum stress in rats and SV-HUC-1 human uroepithelial cells by activating NLRP3/TXNIP aix.
    Bioscience reports, 2019, 10-30, Volume: 39, Issue:10

    Topics: Animals; Apoptosis; Carrier Proteins; Cell Cycle Proteins; Cell Line; Cystitis; Cytokines; Endoplasm

2019
Extracellular vesicles enhance oxidative stress through P38/NF-kB pathway in ketamine-induced ulcerative cystitis.
    Journal of cellular and molecular medicine, 2020, Volume: 24, Issue:13

    Topics: Apoptosis; Cell Line, Tumor; Cell Survival; Cystitis; Cytochalasin D; Extracellular Vesicles; Humans

2020
Disruption of Cav1.2-mediated signaling is a pathway for ketamine-induced pathology.
    Nature communications, 2020, 08-28, Volume: 11, Issue:1

    Topics: Animals; Calcium; Calcium Channels, L-Type; Cell Proliferation; Cystitis; Disease Models, Animal; Hu

2020
Risk of Renal Function Decline in Patients with Ketamine-Associated Uropathy.
    International journal of environmental research and public health, 2020, 10-04, Volume: 17, Issue:19

    Topics: Adult; Analgesics; Cystitis; Female; Glomerular Filtration Rate; Humans; Hydronephrosis; Ketamine; K

2020
    Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS, 2020, Volume: 55, Issue:11-12

    Topics: Acute Kidney Injury; Cystitis; Humans; Ketamine

2020
Recreational ketamine-induced cholangiopathy and ulcerative cystitis.
    The American journal of emergency medicine, 2021, Volume: 45

    Topics: Adolescent; Anesthetics, Dissociative; Cholangitis; Cystitis; Humans; Ketamine; Male; Recreational D

2021
Smaller bladder capacity and stronger bladder contractility in patients with ketamine cystitis are associated with elevated TRPV1 and TRPV4.
    Scientific reports, 2021, 03-04, Volume: 11, Issue:1

    Topics: Adult; Cystitis; Female; Gene Expression Regulation; Humans; Ketamine; Male; Middle Aged; TRPV Catio

2021
Ketamine enhances autophagy and endoplasmic reticulum stress in rats and SV-HUC-1 cells via activating IRE1-TRAF2-ASK1-JNK pathway.
    Cell cycle (Georgetown, Tex.), 2021, Volume: 20, Issue:18

    Topics: Animals; Apoptosis; Autophagy; Cell Line; Cystitis; Disease Models, Animal; Endoplasmic Reticulum St

2021
Ketamine-induced bladder fibrosis involves epithelial-to-mesenchymal transition mediated by transforming growth factor-β1.
    American journal of physiology. Renal physiology, 2017, Oct-01, Volume: 313, Issue:4

    Topics: Analgesics; Animals; Cell Line; Cystitis; Epithelial-Mesenchymal Transition; Female; Fibroblasts; Fi

2017
Clinical Outcome of Augmentation Enterocystoplasty for Patients with Ketamine-induced Cystitis.
    Pain physician, 2017, Volume: 20, Issue:3

    Topics: Adult; Cystitis; Female; Humans; Ketamine; Male; Retrospective Studies; Substance-Related Disorders;

2017
Effective treatment of ketamine-associated cystitis with botulinum toxin type a injection combined with bladder hydrodistention.
    The Journal of international medical research, 2017, Volume: 45, Issue:2

    Topics: Adult; Anesthetics, Dissociative; Botulinum Toxins, Type A; Cystitis; Female; Humans; Hydrotherapy;

2017
Elucidating Mechanisms of Bladder Repair after Hyaluronan Instillation in Ketamine-Induced Ulcerative Cystitis in Animal Model.
    The American journal of pathology, 2017, Volume: 187, Issue:9

    Topics: Animals; Cystitis; Disease Models, Animal; Female; Hyaluronan Receptors; Hyaluronic Acid; Inflammati

2017
Clinical significance of interleukin‑6 and inducible nitric oxide synthase in ketamine‑induced cystitis.
    International journal of molecular medicine, 2018, Volume: 41, Issue:2

    Topics: Aorta; Cyclophosphamide; Cystitis; Gene Expression Regulation; Humans; Interleukin-6; Ketamine; Myoc

2018
The effects of recreational ketamine cystitis on urinary tract reconstruction - a surgical challenge.
    BJU international, 2018, Volume: 121, Issue:3

    Topics: Acute Kidney Injury; Adult; Anastomotic Leak; Anesthetics, Dissociative; Cystitis; Female; Humans; I

2018
Vascular fibrinoid necrosis in the urinary bladder of ketamine abusers: A new finding that may provide a clue to the pathogenesis of ketamine-induced vesicopathy.
    Lower urinary tract symptoms, 2019, Volume: 11, Issue:2

    Topics: Adult; Cystitis; Female; Humans; Ketamine; Necrosis; Substance-Related Disorders; Urinary Bladder; U

2019
Potential Orphan Drug Therapy of Intravesical Liposomal Onabotulinumtoxin-A for Ketamine-Induced Cystitis by Mucosal Protection and Anti-inflammation in a Rat Model.
    Scientific reports, 2018, 04-11, Volume: 8, Issue:1

    Topics: Administration, Intravesical; Analgesics; Animals; Anti-Inflammatory Agents; Botulinum Toxins, Type

2018
Complete reversal of the clinical symptoms and image morphology of ketamine cystitis after intravesical hyaluronic acid instillation: A case report.
    Medicine, 2018, Volume: 97, Issue:28

    Topics: Adjuvants, Immunologic; Administration, Intravesical; Adult; Analgesics; Cystitis; Cystoscopy; Diagn

2018
Epigenetic regulation of COX‑2 expression by DNA hypomethylation via NF‑κB activation in ketamine‑induced ulcerative cystitis.
    International journal of molecular medicine, 2019, Volume: 44, Issue:3

    Topics: Animals; Chromatin Immunoprecipitation; CpG Islands; Cyclooxygenase 2; Cystitis; Disease Models, Ani

2019
'Ketamine-induced ulcerative cystitis' is perhaps better labelled 'ketamine-induced uropathy'.
    Addiction (Abingdon, England), 2013, Volume: 108, Issue:8

    Topics: Anesthetics, Dissociative; Animals; Cystitis; Humans; Ketamine; Male; Memory Disorders; Substance-Re

2013
Ketamine and damage to the urinary tract.
    Addiction (Abingdon, England), 2013, Volume: 108, Issue:8

    Topics: Anesthetics, Dissociative; Animals; Cystitis; Humans; Ketamine; Male; Memory Disorders; Substance-Re

2013
'Addiction' in adolescence: who is really losing control?
    Addiction (Abingdon, England), 2013, Volume: 108, Issue:8

    Topics: Anesthetics, Dissociative; Animals; Cystitis; Humans; Ketamine; Male; Memory Disorders; Substance-Re

2013
Augmentation enterocystoplasty is effective in relieving refractory ketamine-related bladder pain.
    Neurourology and urodynamics, 2014, Volume: 33, Issue:8

    Topics: Adult; Anastomosis, Surgical; Chronic Pain; Cystitis; Female; Humans; Ileum; Ketamine; Male; Pilot P

2014
Nerve hyperplasia: a unique feature of ketamine cystitis.
    Acta neuropathologica communications, 2013, Oct-08, Volume: 1

    Topics: Adult; Aged; Aged, 80 and over; Anesthetics, Dissociative; Cystitis; Humans; Hyperplasia; Illicit Dr

2013
[Urinary tract lesions associated to ketamine consumption].
    Medicina clinica, 2014, Oct-21, Volume: 143, Issue:8

    Topics: Cystitis; Excitatory Amino Acid Antagonists; Humans; Illicit Drugs; Ketamine; Male; Substance-Relate

2014
Chronic hematuria and abdominal pain.
    Clinical toxicology (Philadelphia, Pa.), 2014, Volume: 52, Issue:3

    Topics: Abdominal Pain; Adolescent; Chronic Disease; Common Bile Duct; Cystitis; Dilatation, Pathologic; Fem

2014
Ketamine cystitis: practical considerations in management.
    Scandinavian journal of urology, 2014, Volume: 48, Issue:5

    Topics: Adolescent; Adult; Cystitis; Female; Humans; Ketamine; Lower Urinary Tract Symptoms; Male; Middle Ag

2014
Bilateral hydronephrosis and cystitis resulting from chronic ketamine abuse.
    The western journal of emergency medicine, 2014, Volume: 15, Issue:4

    Topics: Analgesics; Anti-Bacterial Agents; Cystitis; Diagnosis, Differential; Humans; Hydronephrosis; Ketami

2014
Long-term ketamine abuse induces cystitis in rats by impairing the bladder epithelial barrier.
    Molecular biology reports, 2014, Volume: 41, Issue:11

    Topics: Animals; Biomarkers; Blotting, Western; Cystitis; Dose-Response Relationship, Drug; Epithelium; Hist

2014
Histopathological assessment of inflammation and expression of inflammatory markers in patients with ketamine-induced cystitis.
    Molecular medicine reports, 2015, Volume: 11, Issue:4

    Topics: Adolescent; Adult; Analgesics; Biomarkers; Cystitis; Female; Humans; Immunohistochemistry; Inflammat

2015
Autotransplantation for the management of ketamine ureteritis.
    BMJ case reports, 2015, Apr-09, Volume: 2015

    Topics: Adult; Biopsy; Cystectomy; Cystitis; Cystoscopy; Humans; Ketamine; Male; Transplantation, Autologous

2015
Translocation of NF-κB and expression of cyclooxygenase-2 are enhanced by ketamine-induced ulcerative cystitis in rat bladder.
    The American journal of pathology, 2015, Volume: 185, Issue:8

    Topics: Animals; Cell Line; Cyclooxygenase 2; Cystitis; Female; Humans; Ketamine; NF-kappa B; Protein Transp

2015
Ketamine-induced ulcerative cystitis and bladder apoptosis involve oxidative stress mediated by mitochondria and the endoplasmic reticulum.
    American journal of physiology. Renal physiology, 2015, Aug-15, Volume: 309, Issue:4

    Topics: Animals; Antioxidants; Apoptosis; Apoptosis Regulatory Proteins; Biomarkers; Cystitis; Disease Model

2015
Editorial Comment to Possible pathophysiology of ketamine-related cystitis and associated treatment strategies.
    International journal of urology : official journal of the Japanese Urological Association, 2015, Volume: 22, Issue:9

    Topics: Anesthetics, Dissociative; Cystitis; Humans; Ketamine; Urinary Bladder

2015
Clinical Outcome of a Prospective Case Series of Patients With Ketamine Cystitis Who Underwent Standardized Treatment Protocol.
    Urology, 2015, Volume: 86, Issue:2

    Topics: Adult; Clinical Protocols; Cystitis; Excitatory Amino Acid Antagonists; Female; Humans; Ketamine; Ma

2015
The fibrosis of ketamine, a noncompetitive N-methyl-d-aspartic acid receptor antagonist dose-dependent change in a ketamine-induced cystitis rat model.
    Drug and chemical toxicology, 2016, Volume: 39, Issue:2

    Topics: Animals; Cystitis; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Amino Acid A

2016
Re: Long-Term Ketamine Abuse Induces Cystitis in Rats by Impairing the Bladder Epithelial Barrier.
    The Journal of urology, 2016, Volume: 195, Issue:1

    Topics: Animals; Cystitis; Epithelium; Ketamine; Substance-Related Disorders; Urinary Bladder

2016
The clinical presentation and diagnosis of ketamine-associated urinary tract dysfunction in Singapore.
    Singapore medical journal, 2015, Volume: 56, Issue:12

    Topics: Adult; Cystitis; Cystoscopy; Female; Fluoroscopy; Humans; Ketamine; Lower Urinary Tract Symptoms; Ma

2015
A Rare Urachal Cyst in a Case of Ketamine-induced Cystitis Provides Mechanistic Insights.
    Urology, 2016, Volume: 90

    Topics: Adult; Cystitis; Humans; Ketamine; Male; Urachal Cyst

2016
Re: Ketamine Cystitis: Practical Considerations in Management.
    The Journal of urology, 2016, Volume: 195, Issue:2

    Topics: Cystitis; Female; Humans; Ketamine; Lower Urinary Tract Symptoms; Male; Substance-Related Disorders

2016
Intact urothelial barrier function in a mouse model of ketamine-induced voiding dysfunction.
    American journal of physiology. Renal physiology, 2016, 05-01, Volume: 310, Issue:9

    Topics: Anesthetics, Dissociative; Animals; Cystitis; Female; Ketamine; Mice; Mice, Inbred C57BL; Permeabili

2016
Patient characteristics for different therapeutic strategies in the management ketamine cystitis.
    Neurourology and urodynamics, 2017, Volume: 36, Issue:3

    Topics: Adolescent; Adult; Conservative Treatment; Cystitis; Female; Humans; Ketamine; Male; Retrospective S

2017
Ketamine-Induced Apoptosis in Normal Human Urothelial Cells: A Direct, N-Methyl-d-Aspartate Receptor-Independent Pathway Characterized by Mitochondrial Stress.
    The American journal of pathology, 2016, Volume: 186, Issue:5

    Topics: Analgesics; Apoptosis; Calcium Signaling; Cells, Cultured; Cystitis; Dose-Response Relationship, Dru

2016
Mesenchymal stem cells protect against the tissue fibrosis of ketamine-induced cystitis in rat bladder.
    Scientific reports, 2016, 08-02, Volume: 6

    Topics: Analgesics; Animals; Cells, Cultured; Cystitis; Disease Models, Animal; Fibrosis; Humans; Infant, Ne

2016
Letter to the editor: "Urothelial barrier dysfunction: cause or outcome of ketamine-induced voiding dysfunction".
    American journal of physiology. Renal physiology, 2016, 11-01, Volume: 311, Issue:5

    Topics: Cystitis; Humans; Ketamine; Urothelium

2016
Reply to "Letter to the editor: 'Urothelial barrier dysfunction: cause or outcome of ketamine-induced voiding dysfunction'".
    American journal of physiology. Renal physiology, 2016, 11-01, Volume: 311, Issue:5

    Topics: Cystitis; Humans; Ketamine; Urothelium

2016
The putative involvement of actin-binding proteins and cytoskeleton proteins in pathological mechanisms of ketamine cystitis-Revealed by a prospective pilot study using proteomic approaches.
    Proteomics. Clinical applications, 2017, Volume: 11, Issue:3-4

    Topics: Actins; Adult; Cystitis; Cytoskeletal Proteins; Female; Humans; Ketamine; Male; Middle Aged; Pilot P

2017
Alterations of Macrophage Migration Inhibitory Factor Expression in the Nervous System of the Rat Cystitis Model.
    Urologia internationalis, 2017, Volume: 98, Issue:2

    Topics: Animals; Cystitis; Disease Models, Animal; Female; Immunohistochemistry; Inflammation; Intramolecula

2017
Activation of the mTOR dependent signaling pathway underlies ketamine-induced uropathy.
    Neurourology and urodynamics, 2017, Volume: 36, Issue:8

    Topics: Adult; Cystitis; Female; Humans; Ketamine; Male; Microvessels; Middle Aged; Phosphorylation; Ribosom

2017
Ketamine associated cystitis - a case report.
    International emergency nursing, 2009, Volume: 17, Issue:1

    Topics: Adult; Anti-Infective Agents; Ciprofloxacin; Cystitis; Cystoscopy; Emergency Treatment; Humans; Keta

2009
Cystitis associated with chronic ketamine abuse.
    Psychiatry and clinical neurosciences, 2009, Volume: 63, Issue:4

    Topics: Chronic Disease; Cystitis; Female; Humans; Ketamine; Male; Substance-Related Disorders

2009
Ketamine cystitis as a mimic of carcinoma in situ.
    Histopathology, 2009, Volume: 55, Issue:6

    Topics: Adult; Biomarkers, Tumor; Carcinoma; Cystitis; Diagnosis, Differential; Female; Humans; Immunohistoc

2009
Ureteric intestinal metaplasia in association with chronic recreational ketamine abuse.
    Journal of clinical pathology, 2011, Volume: 64, Issue:6

    Topics: Adult; Anesthetics, Dissociative; Cystitis; Humans; Intestines; Ketamine; Male; Metaplasia; Spina Bi

2011
Ketamine-associated vesicopathy.
    QJM : monthly journal of the Association of Physicians, 2012, Volume: 105, Issue:10

    Topics: Adolescent; Analgesics; Biopsy; Cystitis; Cystoscopy; Diagnosis, Differential; Disease Management; H

2012
[Cystitis and ketamine associated bladder dysfunction].
    Actas urologicas espanolas, 2012, Volume: 36, Issue:1

    Topics: Adolescent; Adult; Cross-Sectional Studies; Cystitis; Dose-Response Relationship, Drug; Excitatory A

2012
[Ketamine-induced vesicopathy].
    Psychiatrische Praxis, 2012, Volume: 39, Issue:1

    Topics: Administration, Intranasal; Administration, Intravesical; Adult; Analgesics; Botulinum Toxins, Type

2012
The prevalence and natural history of urinary symptoms among recreational ketamine users.
    BJU international, 2012, Volume: 110, Issue:11

    Topics: Abdominal Pain; Adult; Anesthetics, Dissociative; Cohort Studies; Cystitis; Female; Humans; Illicit

2012
Gourd-shaped bladder associated with ketamine abuse.
    Urologia internationalis, 2012, Volume: 89, Issue:1

    Topics: Adult; Cystitis; Dysuria; Hematuria; Humans; Illicit Drugs; Ketamine; Lower Urinary Tract Symptoms;

2012
Illicit ketamine and its bladder consequences: is it irreversible?
    BMJ case reports, 2012, Oct-30, Volume: 2012

    Topics: Adult; Anesthetics, Dissociative; Cystitis; Female; Humans; Illicit Drugs; Ketamine; Lower Urinary T

2012
Dual involvements of cyclooxygenase and nitric oxide synthase expressions in ketamine-induced ulcerative cystitis in rat bladder.
    Neurourology and urodynamics, 2013, Volume: 32, Issue:8

    Topics: Animals; Cystitis; Ketamine; Nitric Oxide Synthase; Prostaglandin-Endoperoxide Synthases; Rats; Rats

2013
Effects of long-term ketamine administration on rat bladder protein levels: a proteomic investigation using two-dimensional difference gel electrophoresis system.
    International journal of urology : official journal of the Japanese Urological Association, 2013, Volume: 20, Issue:10

    Topics: Anesthetics, Dissociative; Animals; Cystitis; Electrophoresis, Gel, Two-Dimensional; Ketamine; Male;

2013
Involvement of N-methyl-D-aspartate receptors in nociception in the cyclophosphamide-induced vesical pain model in the conscious rat.
    European journal of pain (London, England), 2002, Volume: 6, Issue:4

    Topics: Acrolein; Animals; Antineoplastic Agents, Alkylating; Behavior, Animal; Cyclophosphamide; Cystitis;

2002
Ketamine-associated ulcerative cystitis: a new clinical entity.
    Urology, 2007, Volume: 69, Issue:5

    Topics: Adult; Biopsy, Needle; Cystitis; Cystoscopy; Female; Follow-Up Studies; Humans; Ketamine; Male; Pent

2007
Reply to letter-to-the-editor, Re: Shahani R, Streutker C, Dickson B, et al: Ketamine-associated ulcerative cystitis: a new clinical entity. Urology 69: 810-812, 2007.
    Urology, 2008, Volume: 71, Issue:5

    Topics: Analgesics; Cystitis; Humans; Ketamine; Ulcer

2008
A pediatric case of ketamine-associated cystitis (Letter-to-the-Editor RE: Shahani R, Streutker C, Dickson B, et al: Ketamine-associated ulcerative cystitis: a new clinical entity. Urology 69: 810-812, 2007).
    Urology, 2008, Volume: 71, Issue:6

    Topics: Adolescent; Analgesics; Cystitis; Female; Humans; Ketamine

2008
Automated noninvasive measurement of cyclophosphamide-induced changes in murine micturition frequency and volume and demonstration of pharmacologic sensitivity.
    Urology, 2001, Volume: 57, Issue:6 Suppl 1

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics

2001