Page last updated: 2024-09-28

Autonomic Failure, Progressive

A progressive neurodegenerative condition of the central and autonomic nervous systems characterized by atrophy of the preganglionic lateral horn neurons of the thoracic spinal cord. This disease is generally considered a clinical variant of MULTIPLE SYSTEM ATROPHY. Affected individuals present in the fifth or sixth decade with ORTHOSTASIS and bladder dysfunction; and later develop FECAL INCONTINENCE; anhidrosis; ATAXIA; IMPOTENCE; and alterations of tone suggestive of basal ganglia dysfunction. (From Adams et al., Principles of Neurology, 6th ed, p536)

Synonyms(6)

Synonym
Idiopathic Orthostatic Hypotension, Shy-Drager Type
Shy-Drager Syndrome
Syndrome, Dysautonomia-Orthostatic Hypotension
Autonomic Failure, Progressive
Orthostatic Hypotension, Dysautonomic
Dysautonomia-Orthostatic Hypotension Syndrome

Research Excerpts

Research

Studies (186)

TimeframeStudies, This Condition (%)All Conditions %
pre-199082 (44.09)23.3326
1990's56 (30.11)12.5806
2000's39 (20.97)18.1394
2010's9 (4.84)28.8240
2020's0 (0.00)9.53
DrugIndicatedRelationship StrengthStudiesTrials
gamma-aminobutyric acid0low10
ammonium hydroxide0low10
dihydroxyphenylalanine0low10
pteridines0low10
taurine0low10
normetanephrine0low30
vanilmandelic acid0low10
homovanillic acid0low30
hydroxyindoleacetic acid0low30
acetazolamide0low10
aspirin0low10
baclofen0low10
benserazide0low20
bethanechol0low20
bupivacaine0low10
caffeine0low10
candesartan0low10
clonidine0low50
desipramine0medium21
diazepam0low20
domperidone0medium11
fentanyl0low10
flumazenil0low10
furosemide0low10
indomethacin0low70
isoproterenol0low50
ketamine0low10
labetalol0low10
metyrapone0low10
midodrine0medium72
nomifensine0low10
norfenefrine0low10
octopamine0low10
pindolol0low40
practolol0low30
prazosin0low10
propantheline0low10
propranolol0low50
sulpiride0low10
terazosin0low10
tyramine0low30
prednisolone0low10
aldosterone0low20
prednisone0low20
metaraminol0medium11
serine0low50
aspartic acid0low10
apomorphine0medium11
phenylephrine0medium41
levodopa0medium191
methacholine chloride0low10
pyridostigmine bromide0medium11
yohimbine0medium62
ephedrine0low10
dihydroergotamine0low20
methoxyhydroxyphenylglycol0low60
metanephrine0low20
trimethaphan0medium21
lisuride0low10
bromocriptine0medium21
fludrocortisone0low120
transferrin0low10
glutamic acid0low10
substance p0low30
prenalterol0low30
enkephalin, methionine0low10
dihydroalprenolol0low10
st 10590low10
pergolide0medium11
fomesafen0medium81
atomoxetine hydrochloride0medium21
fluorodopa f 180low10
3-iodobenzylguanidine0low10
amezinium0low10
nicotine0low10
3,4-dihydroxyphenylglycol0low20
droxidopa0low80
carbidopa, levodopa drug combination0low10
5-fluorodopamine0medium51
omega-n-methylarginine0medium11
xamoterol0low20
angiotensin ii0low30
atropine0low30
mycophenolic acid0low10
arginine vasopressin0low20
alprostadil0low10
6-ketoprostaglandin f1 alpha0low10
6-ketoprostaglandin e10low10
entacapone0medium11
2,3-dinor-6-ketoprostaglandin f1alpha0low10
phenylephrine hydrochloride0low10
deamino arginine vasopressin0low10
dihydroergotoxine0low10
ergoline0medium21
alpha-synuclein0low60
losartan potassium0low10
technetium tc 99m exametazime0low10
pituitrin0low30
glucagon0low20
beta-endorphin0low10
neuropeptide y0low20
sodium glutamate0low10
cerebellin0low10
sapropterin0low10
sildenafil citrate0medium11
eye0low10
carbidopa0low30

Protein Targets (968)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
dopamine D1 receptor9009
thioredoxin reductase320032
GLS protein260026
Thrombopoietin2002
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)9009
cytochrome P450 2D6 isoform 19009
cytochrome P450 2C19 precursor9009
ras-related protein Rab-9A5005
histone acetyltransferase KAT2A isoform 1100010
lethal factor (plasmid)8008
POU domain, class 2, transcription factor 10005
Spike glycoprotein110011
ATP-dependent phosphofructokinase160016
Alpha-1B adrenergic receptor015520
Beta-1 adrenergic receptor06313
Alpha-2B adrenergic receptor014721
Alpha-2C adrenergic receptor014721
Alpha-2A adrenergic receptor014721
Alpha-1D adrenergic receptor013518
Alpha-1A adrenergic receptor016622
Beta-2 adrenergic receptor0314
Solute carrier organic anion transporter family member 2A10103
Chain A, TYROSYL-DNA PHOSPHODIESTERASE9009
Chain A, CARBONIC ANHYDRASE II0011
Chain A, CARBONIC ANHYDRASE II0011
Chain A, CARBONIC ANHYDRASE II0011
Chain A, Carbonic Anhydrase Ii0011
Chain A, Carbonic Anhydrase Ii0011
Chain A, Beta-lactamase5005
Chain A, Endochitinase0101
Chain A, Endochitinase0101
Chain A, Endochitinase0101
Chain A, Class Iii Chitinase Chia10101
Chain A, Carbonic anhydrase 130101
Chain A, Carbonic anhydrase II0101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase0101
Chain B, Carbonic anhydrase0101
Chain A, Carbonic anhydrase 20101
Carbonic anhydrase 0002
Carbonic anhydrase 0202
GALC protein7007
GLI family zinc finger 3220022
nuclear receptor subfamily 1, group I, member 3180018
cytochrome P450 family 3 subfamily A polypeptide 4230023
glucocorticoid receptor [Homo sapiens]250025
retinoic acid nuclear receptor alpha variant 1150015
retinoid X nuclear receptor alpha100010
estrogen-related nuclear receptor alpha240024
Carbonic anhydrase 0202
Carbonic anhydrase 0202
arylsulfatase A200020
Carbonic anhydrase0202
euchromatic histone-lysine N-methyltransferase 2440044
Bloom syndrome protein isoform 1140014
thyroid hormone receptor beta isoform a6006
nuclear factor erythroid 2-related factor 2 isoform 1160016
geminin240024
peripheral myelin protein 22140014
survival motor neuron protein isoform d6006
muscleblind-like protein 1 isoform 12002
Gamma-aminobutyric acid receptor subunit pi119323
ATP-binding cassette sub-family C member 3027027
Multidrug resistance-associated protein 4027028
Carbonic anhydrase0202
Solute carrier family 22 member 60404
Carbonic anhydrase 1204110
Prolyl endopeptidase0101
Carbonic anhydrase-related protein 110102
Bile salt export pump039039
Glycogen phosphorylase, muscle form0202
Renin0303
Carbonic anhydrase 108119
Carbonic anhydrase 208118
Carbonic anhydrase 20202
Cytochrome P450 1A20404
Carbonic anhydrase 30419
Cathepsin B0101
Cytochrome P450 3A40909
Steryl-sulfatase0101
5-hydroxytryptamine receptor 2C0718
Polyunsaturated fatty acid 5-lipoxygenase0101
Cytochrome P450 2C80404
Cytochrome P450 2D6010010
Cytochrome P450 2A60314
Cytochrome P450 2C9 0909
5-hydroxytryptamine receptor 2A0617
Androgen receptor0505
Gamma-aminobutyric acid receptor subunit beta-1119323
Translocator protein0326
Gamma-aminobutyric acid receptor subunit delta119323
Gamma-aminobutyric acid receptor subunit gamma-2119525
Gamma-aminobutyric acid receptor subunit alpha-5119323
Gamma-aminobutyric acid receptor subunit alpha-3119323
Cannabinoid receptor 10101
Arachidonate 5-lipoxygenase-activating protein0101
Cytochrome P450 2B60101
Carbonic anhydrase 40318
Carbonic anhydrase 60419
Gamma-aminobutyric acid receptor subunit gamma-1119323
Gamma-aminobutyric acid receptor subunit alpha-2119323
Carbonic anhydrase 5A, mitochondrial0101
Adenosine receptor A10507
Serum paraoxonase/arylesterase 10303
Dipeptidyl peptidase 40001
Gamma-aminobutyric acid receptor subunit alpha-4119323
Gamma-aminobutyric acid receptor subunit gamma-3119323
Endochitinase0101
Gamma-aminobutyric acid receptor subunit alpha-6119323
Adenosine receptor A2a0519
5-hydroxytryptamine receptor 2B0617
Sodium-dependent serotonin transporter0606
Delta-type opioid receptor0606
Cytochrome P450 2C190505
Delta-type opioid receptor0606
Mu-type opioid receptor0516
Carbonic anhydrase 5A, mitochondrial04110
Carbonic anhydrase0102
Kappa-type opioid receptor0303
Carbonic anhydrase 70419
Carbonic anhydrase0101
D(1A) dopamine receptor4105
Corticosteroid 11-beta-dehydrogenase isozyme 10202
Carbonic anhydrase0203
D(2) dopamine receptor014621
Gamma-aminobutyric acid receptor subunit alpha-11110526
Gamma-aminobutyric acid receptor subunit beta-3119323
Gamma-aminobutyric acid receptor subunit beta-2119525
Cholinesterase0303
Carbonic anhydrase 0101
Mu-type opioid receptor0606
Fatty-acid amide hydrolase 10202
Beta-carbonic anhydrase 10202
Carbonic anhydrase 20202
Glutamate receptor ionotropic, NMDA 2B0629
Squalene synthase0101
Neuronal acetylcholine receptor subunit alpha-70528
Carbonic anhydrase 904111
Carbonic anhydrase0101
Carbonic anhydrase, alpha family 0202
Carbonic anhydrase 0203
Carbonic anhydrase 30101
Carbonic anhydrase0103
Carbonic anhydrase0204
Carbonic anhydrase 0202
Sigma intracellular receptor 20202
Delta carbonic anhydrase0202
Sigma non-opioid intracellular receptor 10303
Renin0101
Carbonic anhydrase 0203
Endochitinase A10101
Multidrug resistance-associated protein 10101
Carbonic anhydrase 130214
GABA theta subunit119323
Canalicular multispecific organic anion transporter 1024024
Carbonic anhydrase 40304
Carbonic anhydrase 150204
Acidic mammalian chitinase0101
Carbonic anhydrase 130307
Carbonic anhydrase 70101
Gamma-aminobutyric acid receptor subunit epsilon119323
Carbonic anhydrase 0101
Carbonic anhydrase 140319
Carbonic anhydrase 0101
Carbonic anhydrase 2, isoform A 0101
Carbonic anhydrase 5B, mitochondrial04110
AR protein300030
nuclear factor erythroid 2-related factor 2 isoform 27007
Sex hormone-binding globulin0011
Corticosteroid-binding globulin0202
Mineralocorticoid receptor 0336
Mineralocorticoid receptor0101
Solute carrier organic anion transporter family member 1A10001
Guanine nucleotide-binding protein G2002
TDP1 protein290029
estrogen nuclear receptor alpha280028
peroxisome proliferator activated receptor gamma9009
Cellular tumor antigen p53160016
Thromboxane-A synthase 0404
Prostaglandin E2 receptor EP3 subtype0202
Prostaglandin E2 receptor EP4 subtype0213
Prostaglandin E2 receptor EP1 subtype0202
Prostacyclin receptor0112
Nuclear receptor subfamily 4 group A member 20011
Nuclear receptor subfamily 4 group A member 20011
Nuclear receptor subfamily 4 group A member 20011
Prostaglandin E2 receptor EP2 subtype0213
Solute carrier organic anion transporter family member 2A10001
Solute carrier organic anion transporter family member 2B10101
Solute carrier organic anion transporter family member 3A10001
glucocerebrosidase6006
DNA polymerase kappa isoform 1100010
Atrial natriuretic peptide receptor 30101
Type-1A angiotensin II receptor 0325
Type-1 angiotensin II receptor0011
Type-1B angiotensin II receptor0404
Type-1 angiotensin II receptor0539
Type-2 angiotensin II receptor0303
Type-2 angiotensin II receptor0303
Chain A, Putative fructose-1,6-bisphosphate aldolase5005
Chain A, HADH2 protein7007
Chain B, HADH2 protein7007
Chain A, 2-oxoglutarate Oxygenase120012
Luciferase9009
acetylcholinesterase100010
phosphopantetheinyl transferase110011
hypoxia-inducible factor 1 alpha subunit7007
RAR-related orphan receptor gamma150015
Microtubule-associated protein tau9009
aldehyde dehydrogenase 1 family, member A1160016
estrogen receptor 2 (ER beta)9009
progesterone receptor130013
regulator of G-protein signaling 4260026
farnesoid X nuclear receptor8008
cytochrome P450 2D6120012
peroxisome proliferator-activated receptor delta8008
aryl hydrocarbon receptor130013
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a9009
thyroid stimulating hormone receptor9009
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a3003
v-jun sarcoma virus 17 oncogene homolog (avian)8008
Histone H2A.x110011
cellular tumor antigen p53 isoform a3003
cytochrome P450 2C9 precursor7007
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 17007
vitamin D3 receptor isoform VDRA120012
potassium voltage-gated channel subfamily H member 2 isoform d8008
thyroid hormone receptor beta isoform 2170017
mitogen-activated protein kinase 16006
nuclear receptor ROR-gamma isoform 18008
cytochrome P450 3A4 isoform 1110011
lamin isoform A-delta10200020
Solute carrier family 22 member 1 010014
Polyunsaturated fatty acid lipoxygenase ALOX15B4004
Voltage-dependent calcium channel gamma-2 subunit8008
Integrin beta-32114
Integrin alpha-IIb2114
5-hydroxytryptamine receptor 1A08311
Tryptophan 5-hydroxylase 10202
D(2) dopamine receptor022732
D09010
D(3) dopamine receptor0808
5-hydroxytryptamine receptor 1A028433
Glutamate receptor 293113
D(2) dopamine receptor0303
D(1A) dopamine receptor015321
D(4) dopamine receptor0629
D(1B) dopamine receptor0203
D(1B) dopamine receptor0707
5-hydroxytryptamine receptor 2A016420
5-hydroxytryptamine receptor 1B024125
5-hydroxytryptamine receptor 1D0516
D(4) dopamine receptor0718
5-hydroxytryptamine receptor 1F0516
5-hydroxytryptamine receptor 60314
5-hydroxytryptamine receptor 7 0415
5-hydroxytryptamine receptor 5A0314
5-hydroxytryptamine receptor 5B0314
D(3) dopamine receptor019224
5-hydroxytryptamine receptor 3A0415
Histamine H2 receptor91113
5-hydroxytryptamine receptor 70707
E3 ubiquitin-protein ligase Mdm20101
D0101
5-hydroxytryptamine receptor 4 0314
D0303
ATPase family AAA domain-containing protein 59009
Ataxin-2150015
Sigma non-opioid intracellular receptor 10819
5-hydroxytryptamine receptor 3B0415
Vasopressin V2 receptor0326
Oxytocin receptor0123
Vasopressin V1a receptor0033
Vasopressin V1a receptor0336
Vasopressin V1b receptor0224
Vasopressin V2 receptor0011
Vasopressin V1b receptor0113
Translocator protein0203
Oxytocin receptor0112
Vasopressin V2 receptor 0224
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE120012
Chain A, Ferritin light chain3003
Metabotropic glutamate receptor 60124
Excitatory amino acid transporter 40202
Glutamate transporter homolog0011
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase0101
5-hydroxytryptamine receptor 1D0203
Glutamate receptor ionotropic, NMDA 1 0528
Excitatory amino acid transporter 10304
Excitatory amino acid transporter 20304
Excitatory amino acid transporter 30304
Glutamate receptor ionotropic, NMDA 2A 0528
Glutamate receptor ionotropic, NMDA 2C0528
Metabotropic glutamate receptor 10124
Metabotropic glutamate receptor 20124
Carbonic anhydrase-like protein, putative0003
Glutamate receptor ionotropic, NMDA 2D0528
Glutamate receptor ionotropic, NMDA 3B0528
Glutamate receptor ionotropic, NMDA 3A0528
Chain A, Phospholipase A2 isoform 30011
GTP-binding protein (rab7)0011
ras protein, partial0011
interleukin 83003
thyroid stimulating hormone receptor8008
hypothetical protein, conserved2002
EWS/FLI fusion protein140014
Rac1 protein0011
IDH16006
cell division cycle 42 (GTP binding protein, 25kDa), partial0011
DNA polymerase iota isoform a (long)7007
muscarinic acetylcholine receptor M1130013
Prostaglandin-H2 D-isomerase0202
Prostaglandin G/H synthase 1 0203
Prostaglandin G/H synthase 2 0203
Epidermal growth factor receptor0505
Fatty acid-binding protein, liver0303
Myeloperoxidase0101
Prostaglandin G/H synthase 10405
Seed linoleate 13S-lipoxygenase-10101
Glutathione hydrolase 1 proenzyme0101
Prostaglandin G/H synthase 10303
Substance-P receptor0303
Prostaglandin G/H synthase 20516
Urotensin-2 receptor0101
4-aminobutyrate aminotransferase, mitochondrial0101
Nuclear receptor ROR-gamma4004
Ras-related protein Rab-2A0011
Prostaglandin G/H synthase 20303
Rho-associated protein kinase 20202
Nicotinate phosphoribosyltransferase0202
Solute carrier family 22 member 200101
Solute carrier family 22 member 60101
Sigma non-opioid intracellular receptor 10112
glp-1 receptor, partial8008
Sodium-dependent noradrenaline transporter 011213
pregnane X nuclear receptor170017
cystic fibrosis transmembrane conductance regulator0101
DNA polymerase beta2002
short transient receptor potential channel 6 isoform 10011
5-hydroxytryptamine receptor 4016016
Muscarinic acetylcholine receptor M20429
Muscarinic acetylcholine receptor M40316
Muscarinic acetylcholine receptor M10316
Muscarinic acetylcholine receptor M30316
Muscarinic acetylcholine receptor M40417
Muscarinic acetylcholine receptor M50316
Muscarinic acetylcholine receptor M50316
Muscarinic acetylcholine receptor M20317
Muscarinic acetylcholine receptor M10429
Muscarinic acetylcholine receptor M10001
Muscarinic acetylcholine receptor M30428
Alpha-1D adrenergic receptor024736
5-hydroxytryptamine receptor 2C017421
Muscarinic acetylcholine receptor M40202
Reverse transcriptase/RNaseH 0001
Muscarinic acetylcholine receptor0113
ATAD5 protein, partial120012
NFKB1 protein, partial9009
67.9K protein5005
activating transcription factor 64004
D(1A) dopamine receptor140014
Gamma-aminobutyric acid type B receptor subunit 20224
Gamma-aminobutyric acid type B receptor subunit 20303
Gamma-aminobutyric acid type B receptor subunit 10224
Gamma-aminobutyric acid type B receptor subunit 10202
chromobox protein homolog 1190019
serine/threonine-protein kinase mTOR isoform 18008
M-phase phosphoprotein 8100010
Zinc finger protein mex-50011
POsterior Segregation0022
Genome polyprotein0101
Replicase polyprotein 1ab0303
Hexokinase-20101
USP1 protein, partial5005
flap endonuclease 15005
Genome polyprotein 0112
Fumarate hydratase6006
G7007
polyprotein6006
peptidyl-prolyl cis-trans isomerase NIMA-interacting 15005
Interferon beta100010
HLA class I histocompatibility antigen, B alpha chain 7007
ATP-dependent translocase ABCB10303
ATP-dependent translocase ABCB10709
Beta-1 adrenergic receptor014822
Alpha-2A adrenergic receptor026535
Alpha-2B adrenergic receptor024230
Alpha-2C adrenergic receptor023431
ATP-dependent translocase ABCB10303
Alpha-synuclein1203
5-hydroxytryptamine receptor 2B020121
5-hydroxytryptamine receptor 6014115
Inositol hexakisphosphate kinase 17007
cytochrome P450 2C9, partial7007
Potassium channel subfamily K member 30101
Potassium channel subfamily K member 30101
Potassium channel subfamily K member 20022
Potassium channel subfamily K member 90101
Chain A, Glycogen Phosphorylase0101
Chain A, Glycogen phosphorylase, liver form0011
Chain A, glycogen phosphorylase, liver form0011
Chain A, Glycogen phosphorylase, liver form0011
Chain A, Glycogen phosphorylase, liver form0011
Chain A, Chitinase0101
atrial natriuretic peptide receptor 1 precursor5005
Cholinesterase0101
Glycogen phosphorylase, liver form0101
Glycogen phosphorylase, muscle form0101
Replicase polyprotein 1ab0202
Adenosine receptor A30415
Amine oxidase [flavin-containing] A0506
Acetylcholinesterase0202
Amine oxidase [flavin-containing] B0607
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0101
Adenosine receptor A30101
Adenosine receptor A2a0427
Adenosine receptor A2b0102
Adenosine receptor A2b0214
Adenosine receptor A10114
Vasopressin V2 receptor0001
Serine/threonine-protein kinase mTOR0101
Adenosine receptor A2a0101
Adenosine receptor A10202
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 0101
DNA-dependent protein kinase catalytic subunit0101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B0101
Adenylate cyclase type 10001
Chitotriosidase-10101
Serine-protein kinase ATM0101
Serine/threonine-protein kinase ATR0101
Adenosine receptor A2b0102
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C0101
Palmitoleoyl-protein carboxylesterase NOTUM0123
Endochitinase B10101
Phosphodiesterase 0101
Broad substrate specificity ATP-binding cassette transporter ABCG20203
Guanine deaminase0101
Receptor tyrosine-protein kinase erbB-20101
Aldo-keto reductase family 1 member B10606
60 kDa chaperonin0101
60 kDa heat shock protein, mitochondrial0101
Beta-3 adrenergic receptor07815
Type-1 angiotensin II receptor0202
10 kDa heat shock protein, mitochondrial0101
Thiosulfate sulfurtransferase0101
60 kDa chaperonin 0101
10 kDa chaperonin 0101
Leukotriene B4 receptor 20011
Chain A, Cruzipain4004
Beta-1 adrenergic receptor 0158
Alpha-1B adrenergic receptor 0022
Membrane primary amine oxidase 0101
5-hydroxytryptamine receptor 3A0011
Solute carrier family 22 member 30404
Alpha-1A adrenergic receptor0426
Alpha-2B adrenergic receptor0305
Alpha-1A adrenergic receptor081126
Alpha-1B adrenergic receptor07921
Inositol monophosphatase 15005
Alpha-2C adrenergic receptor0305
Alpha-2A adrenergic receptor0305
Alpha-2A adrenergic receptor0202
Nischarin0202
Solute carrier family 22 member 10404
Multidrug and toxin extrusion protein 10606
Nischarin0101
huntingtin isoform 22002
atrial natriuretic peptide receptor 2 precursor2002
Solute carrier family 22 member 20404
Solute carrier family 22 member 30101
Albumin0247
Angiotensin-converting enzyme0404
Sodium-dependent dopamine transporter0606
Histamine H1 receptor0101
Sodium-dependent serotonin transporter0808
Cytochrome P450 2J20505
Voltage-dependent N-type calcium channel subunit alpha-1B0101
Sodium-dependent dopamine transporter 0606
Potassium voltage-gated channel subfamily H member 2013013
Sodium channel protein type 5 subunit alpha0303
Nuclear receptor subfamily 3 group C member 3 0404
Histamine H3 receptor0102
Solute carrier family 22 member 20202
Solute carrier family 22 member 40101
Transporter0416
Histamine H3 receptor0101
Gamma-aminobutyric acid 0213
vitamin D (1,25- dihydroxyvitamin D3) receptor120012
Gamma-aminobutyric acid receptor subunit pi0505
Gamma-aminobutyric acid receptor subunit delta0505
Voltage-dependent L-type calcium channel subunit alpha-1F0202
Alpha-1-acid glycoprotein 10001
Albumin0011
Gamma-aminobutyric acid receptor subunit alpha-10404
Gamma-aminobutyric acid receptor subunit beta-10404
Neuronal acetylcholine receptor subunit alpha-425210
Gamma-aminobutyric acid receptor subunit alpha-20404
Gamma-aminobutyric acid receptor subunit alpha-30404
Neuronal acetylcholine receptor subunit beta-225210
Gamma-aminobutyric acid receptor subunit alpha-10549
Gamma-aminobutyric acid receptor subunit alpha-60213
Gamma-aminobutyric acid receptor subunit beta-10516
Gamma-aminobutyric acid receptor subunit gamma-20538
Gamma-aminobutyric acid receptor subunit alpha-40404
Gamma-aminobutyric acid receptor subunit gamma-20404
Gamma-aminobutyric acid receptor subunit gamma-20213
Gamma-aminobutyric acid receptor subunit delta0213
Gamma-aminobutyric acid receptor subunit alpha-20213
Gamma-aminobutyric acid receptor subunit alpha-30213
Gamma-aminobutyric acid receptor subunit gamma-30213
Gamma-aminobutyric acid receptor subunit beta-30538
Translocator protein0101
Translocator protein0101
Cholecystokinin receptor type A0101
Gastrin/cholecystokinin type B receptor0101
Gamma-aminobutyric acid receptor subunit alpha-50549
Gamma-aminobutyric acid receptor subunit alpha-30538
Gamma-aminobutyric acid receptor subunit alpha-20527
Gamma-aminobutyric acid receptor subunit beta-20527
Gamma-aminobutyric acid receptor subunit alpha-40516
Gamma-aminobutyric acid receptor subunit beta-10213
Gamma-aminobutyric acid receptor subunit alpha-10213
Gamma-aminobutyric acid receptor subunit beta-30213
Gamma-aminobutyric acid receptor subunit epsilon0505
Voltage-dependent L-type calcium channel subunit alpha-1D 0202
Voltage-dependent L-type calcium channel subunit alpha-1S0202
Voltage-dependent L-type calcium channel subunit alpha-1C0303
Gamma-aminobutyric acid receptor subunit alpha-60516
Gamma-aminobutyric acid receptor subunit alpha-50213
Gamma-aminobutyric acid receptor subunit gamma-10505
Gamma-aminobutyric acid receptor subunit pi0213
Sphingosine-1-phosphate lyase 10101
Gamma-aminobutyric acid receptor subunit gamma-30505
Gamma-aminobutyric acid receptor subunit alpha-40213
Gamma-aminobutyric acid receptor subunit theta0213
Gamma-aminobutyric acid receptor subunit gamma-10213
Gamma-aminobutyric acid receptor subunit theta0505
Beta-2 adrenergic receptor 0145
SMAD family member 24004
SMAD family member 34004
caspase 7, apoptosis-related cysteine protease2002
caspase-32002
Caspase-71001
caspase-31001
Multidrug and toxin extrusion protein 20303
Chain A, JmjC domain-containing histone demethylation protein 3A2002
acid sphingomyelinase2002
serine-protein kinase ATM isoform a1001
mu-type opioid receptor isoform MOR-10033
importin subunit beta-1 isoform 13003
fatty acid synthase0101
snurportin-13003
5-hydroxytryptamine receptor 2A0033
Chain A, ATP-DEPENDENT DNA HELICASE Q12002
endonuclease IV6006
15-lipoxygenase, partial3003
polyunsaturated fatty acid lipoxygenase ALOX121001
runt-related transcription factor 1 isoform AML1b1001
core-binding factor subunit beta isoform 21001
Glutamate receptor 11315
Glutamate receptor 31315
Glutamate receptor 41315
Caspase-71001
Smad34004
alpha-galactosidase6006
peripheral myelin protein 22 isoform 14004
ubiquitin carboxyl-terminal hydrolase 2 isoform a2002
Retinoic acid receptor RXR-alpha0011
Histamine H1 receptor0505
Mu-type opioid receptor0527
Kappa-type opioid receptor0516
Disintegrin and metalloproteinase domain-containing protein 171001
Nuclear receptor subfamily 1 group I member 20022
Nuclear receptor subfamily 1 group I member 20011
histone deacetylase 9 isoform 32002
heat shock protein beta-12002
histone-lysine N-methyltransferase 2A isoform 2 precursor2002
UDP-glucuronosyltransferase 1A90002
Catechol O-methyltransferase0101
Catechol O-methyltransferase0101
UDP-glucuronosyltransferase 2B150001
Alpha-ketoglutarate-dependent dioxygenase FTO0202
Adenylate cyclase 0101
Tyrosine-protein kinase Lck0202
Tyrosine-protein kinase Fyn0202
Beta-2 adrenergic receptor012922
5-hydroxytryptamine receptor 1B0516
5-hydroxytryptamine receptor 5A0101
Kappa-type opioid receptor0101
Delta-type opioid receptor0314
Mu-type opioid receptor0101
nuclear receptor subfamily 1, group I, member 23003
Bile salt export pump0707
TAR DNA-binding protein 434004
thyrotropin-releasing hormone receptor2002
Glucose-6-phosphate 1-dehydrogenase0101
Corticosteroid 11-beta-dehydrogenase isozyme 10101
6-phosphogluconate dehydrogenase, decarboxylating0101
Holo-[acyl-carrier-protein] synthase0101
Sodium/bile acid cotransporter0202
G-protein coupled receptor 350112
CDGSH iron-sulfur domain-containing protein 10202
Gamma-aminobutyric acid receptor subunit rho-30011
Hsf1 protein0011
bromodomain adjacent to zinc finger domain 2B2002
transcriptional regulator ERG isoform 32002
neuropeptide S receptor isoform A4004
Histone deacetylase 30101
Sodium- and chloride-dependent GABA transporter 10202
Gamma-aminobutyric acid receptor subunit rho-10022
Gamma-aminobutyric acid receptor subunit rho-20011
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent taurine transporter0202
Sodium- and chloride-dependent GABA transporter 20202
Sodium- and chloride-dependent GABA transporter 30202
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Sodium- and chloride-dependent betaine transporter0202
Sodium- and chloride-dependent betaine transporter0101
Sodium- and chloride-dependent GABA transporter 30101
Histone deacetylase 40101
4-aminobutyrate aminotransferase, mitochondrial0001
4-aminobutyrate aminotransferase, mitochondrial0001
Histone deacetylase 10101
Sterol O-acyltransferase 10011
Proton-coupled amino acid transporter 10303
Histone deacetylase 70101
Histone deacetylase 20101
Polyamine deacetylase HDAC100101
Histone deacetylase 11 0101
Histone deacetylase 80101
Platelet glycoprotein VI0011
Sodium- and chloride-dependent GABA transporter 20101
Histone deacetylase 60101
Histone deacetylase 90101
Histone deacetylase 50101
Chain A, GLUTAMATE RECEPTOR SUBUNIT 20101
Chain A, Glutamate Receptor Subunit 20101
Chain B, Glutamate Receptor Subunit 20101
Chain A, Slr1257 protein0011
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]0101
beta-2 adrenergic receptor3003
Metabotropic glutamate receptor 80202
Glutamate receptor ionotropic, NMDA 2D0202
Glutamate receptor ionotropic, NMDA 3B0202
Glutathione reductase, mitochondrial0202
Bifunctional aspartokinase/homoserine dehydrogenase 10101
Prothrombin0011
ATP-citrate synthase 0101
Glutamate receptor ionotropic, kainate 10213
Metabotropic glutamate receptor 10112
Metabotropic glutamate receptor 20011
Metabotropic glutamate receptor 30011
Metabotropic glutamate receptor 40112
Metabotropic glutamate receptor 50011
Metabotropic glutamate receptor 60011
Metabotropic glutamate receptor 70011
Glutamate receptor ionotropic, kainate 10112
Metabotropic glutamate receptor 50113
Glutamate receptor ionotropic, kainate 20213
Glutamate receptor 10213
Glutamate receptor 20213
Glutamate receptor 30112
Glutamate receptor ionotropic, kainate 30202
Metabotropic glutamate receptor 80011
Glutamate receptor 40213
Excitatory amino acid transporter 3 0001
Glutamate racemase0001
Metabotropic glutamate receptor 80112
Glutamate receptor ionotropic, kainate 40202
Glutamate carboxypeptidase 20101
Glutamate receptor ionotropic, NMDA 10303
Glutamate receptor ionotropic, NMDA 2A0303
Glutamate receptor ionotropic, kainate 20112
Glutamate receptor ionotropic, kainate 30101
Glutamate receptor ionotropic, NMDA 2B0303
Metabotropic glutamate receptor 70113
Metabotropic glutamate receptor 30113
Metabotropic glutamate receptor 40113
Glutamate receptor ionotropic, NMDA 2C0202
Glutamate receptor ionotropic, kainate 50101
Glutamate receptor ionotropic, kainate 50202
Glutamate racemase0001
Prolyl 4-hydroxylase0101
Glutamate receptor ionotropic, NMDA 3A0202
ClpP2002
lysosomal alpha-glucosidase preproprotein4004
Solute carrier family 22 member 80001
urokinase-type plasminogen activator precursor3003
plasminogen precursor3003
urokinase plasminogen activator surface receptor precursor3003
Uracil nucleotide/cysteinyl leukotriene receptor0202
Chain A, membrane-associated prostaglandin E synthase-20101
Parkin3003
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
Prostaglandin E synthase0101
3',5'-cyclic-AMP phosphodiesterase 0101
Solute carrier organic anion transporter family member 2B1 0202
Cytochrome c oxidase subunit 20101
Phospholipase A2, major isoenzyme0101
Procathepsin L0101
Interleukin-80101
Androgen receptor0213
Polyunsaturated fatty acid 5-lipoxygenase0102
Aldo-keto reductase family 1 member B10101
Aldo-keto reductase family 1 member B10202
Aldo-keto reductase family 1 member C40101
Prostaglandin G/H synthase 10101
Indoleamine 2,3-dioxygenase 10101
Caspase-10001
Nitric oxide synthase, inducible0202
Multidrug resistance-associated protein 1 0101
Bifunctional epoxide hydrolase 20101
Prostaglandin G/H synthase 2 0101
Peroxisome proliferator-activated receptor gamma0022
Aldo-keto reductase family 1 member C30202
C-X-C chemokine receptor type 30101
Aldo-keto reductase family 1 member C2 0101
Prostaglandin D2 receptor 0202
Solute carrier organic anion transporter family member 1A30101
Lactoylglutathione lyase0101
Aldo-keto reductase family 1 member C10101
Prostaglandin G/H synthase 20102
Solute carrier family 22 member 60101
Solute carrier family 22 member 70001
Prostaglandin G/H synthase 1 0101
Solute carrier family 22 member 80101
Dehydrogenase/reductase SDR family member 90101
P2Y purinoceptor 120101
Solute carrier organic anion transporter family member 1B30202
Cytosolic phospholipase A2 gamma0101
Prostaglandin D2 receptor 20112
Solute carrier organic anion transporter family member 1B10202
NPYLR7B0011
hexokinase-4 isoform 13003
glucokinase regulatory protein3003
Beta-2 adrenergic receptor0418
Polyunsaturated fatty acid lipoxygenase ALOX150202
Beta-2 adrenergic receptor0112
Beta-adrenergic receptor kinase 10011
Beta-3 adrenergic receptor0011
Beta-3 adrenergic receptor0314
Beta-1 adrenergic receptor0213
Taste receptor type 2 member 380011
Taste receptor type 2 member 390011
Taste receptor type 2 member 400011
Taste receptor type 2 member 410011
Taste receptor type 2 member 430011
Taste receptor type 2 member 310011
Taste receptor type 2 member 450011
Taste receptor type 2 member 460011
Taste receptor type 2 member 300011
Taste receptor type 2 member 190011
Taste receptor type 2 member 200011
Taste receptor type 2 member 500011
Taste receptor type 2 member 600011
Taste receptor type 2 member 420011
Beta-2 adrenergic receptor0157
Taste receptor type 2 member 160011
Taste receptor type 2 member 140011
Taste receptor type 2 member 130011
Taste receptor type 2 member 100011
Taste receptor type 2 member 90011
Taste receptor type 2 member 80011
Taste receptor type 2 member 70011
Taste receptor type 2 member 50011
Taste receptor type 2 member 40011
Taste receptor type 2 member 30011
Taste receptor type 2 member 10011
2,3-bisphosphoglycerate-independent phosphoglycerate mutase1001
Acetylcholinesterase0202
Rap guanine nucleotide exchange factor 31001
Sodium channel protein type 4 subunit alpha0203
Heparanase0011
WRN1001
integrase, partial0101
lens epithelium-derived growth factor p750101
apical membrane antigen 1, AMA11001
pyruvate kinase1001
DNA polymerase eta isoform 11001
Polyphenol oxidase 20002
Plasma kallikrein0001
Tyrosinase0101
Solute carrier family 15 member 10101
Large neutral amino acids transporter small subunit 10101
SLC16A10 protein0001
Monocarboxylate transporter 100001
phosphoglycerate kinase1001
Histamine H2 receptor0202
cGMP-inhibited 3',5'-cyclic phosphodiesterase B0101
cGMP-inhibited 3',5'-cyclic phosphodiesterase A0101
5-hydroxytryptamine receptor 1A0101
Type-1 angiotensin II receptor0101
Macrophage migration inhibitory factor0202
galanin receptor type 30101
Steroid 17-alpha-hydroxylase/17,20 lyase0101
Aromatase0101
Cytochrome P450 11B1, mitochondrial 0101
Cytochrome P450 11B1, mitochondrial0101
Cytochrome P450 11B1, mitochondrial0101
Cytochrome P450 11B2, mitochondrial0101
Chain A, Inosine-5'-Monophosphate Dehydrogenase 20101
Inosine-5'-monophosphate dehydrogenase 20202
Inosine-5'-monophosphate dehydrogenase 1 0202
UDP-glucuronosyltransferase 1A1 0001
Inosine-5'-monophosphate dehydrogenase0102
UDP-glucuronosyltransferase 1A70001
UDP-glucuronosyltransferase 1A100001
UDP-glucuronosyltransferase 1A80001
Neuropeptide Y receptor type 10202
Neuropeptide Y receptor type 20202
5-hydroxytryptamine receptor 3E0101
Neuronal acetylcholine receptor subunit alpha-40213
Transient receptor potential cation channel subfamily A member 10011
5-hydroxytryptamine receptor 3B0101
Acetylcholine receptor subunit alpha0213
Acetylcholine receptor subunit alpha0213
Acetylcholine receptor subunit beta0213
Acetylcholine receptor subunit gamma0213
Acetylcholine receptor subunit delta0213
Neuronal acetylcholine receptor subunit alpha-30225
Acetylcholine receptor subunit gamma0213
Neuronal acetylcholine receptor subunit alpha-40101
Acetylcholine receptor subunit beta0213
Neuronal acetylcholine receptor subunit alpha-20225
Neuronal acetylcholine receptor subunit beta-30225
Neuronal acetylcholine receptor subunit beta-40225
Neuronal acetylcholine receptor subunit beta-20213
Neuronal acetylcholine receptor subunit alpha-50225
Cytochrome P450 2A50101
Acetylcholine receptor subunit beta-like 20202
Neuronal acetylcholine receptor subunit alpha-50011
Neuronal acetylcholine receptor subunit beta-40213
Neuronal acetylcholine receptor subunit alpha-30213
Neuronal acetylcholine receptor subunit alpha-70224
Neuronal acetylcholine receptor subunit alpha-60225
Neuronal acetylcholine receptor subunit alpha-90225
Neuronal acetylcholine receptor subunit alpha-40213
5-hydroxytryptamine receptor 3A0123
Neuronal acetylcholine receptor subunit alpha-70202
Acetylcholine-binding protein0112
Acetylcholine receptor subunit epsilon0011
Neuronal acetylcholine receptor subunit beta-30112
Acetylcholine receptor subunit delta0213
Neuronal acetylcholine receptor subunit alpha-20101
Neuronal acetylcholine receptor subunit alpha-60112
Cytochrome P450 2A130112
Neuronal acetylcholine receptor subunit alpha-50202
Liver carboxylesterase B-10101
5-hydroxytryptamine receptor 3D0101
Transient receptor potential cation channel subfamily A member 10011
Neuronal acetylcholine receptor subunit beta-30202
Neuronal acetylcholine receptor subunit beta-40202
Neuronal acetylcholine receptor subunit alpha-30202
Soluble acetylcholine receptor0101
5-hydroxytryptamine receptor 3C0101
Neuronal acetylcholine receptor subunit alpha-20202
Neuronal acetylcholine receptor subunit beta-20213
Neuronal acetylcholine receptor subunit alpha-100225
Neuronal acetylcholine receptor subunit alpha-60202
Integrin beta0011
Glycoprotein IIb0011
tumor susceptibility gene 101 protein1001
Transporter0101
Trace amine-associated receptor 10022
N(G),N(G)-dimethylarginine dimethylaminohydrolase 10001
N(G),N(G)-dimethylarginine dimethylaminohydrolase 10102
Neutrophil elastase0101
Proteinase-activated receptor 10101
Nitric oxide synthase, endothelial0101
Nitric oxide synthase, endothelial0202
Nitric oxide synthase, brain0213
Nitric oxide synthase, brain 0202
Nitric oxide synthase, inducible0202
Collagenase 30101
Nitric oxide synthase, brain0101
NPC intracellular cholesterol transporter 1 precursor2002
Lysine-specific histone demethylase 1A0101
Indoleamine 2,3-dioxygenase 10101
Amine oxidase [flavin-containing] B0101
Membrane primary amine oxidase0101
Single-stranded DNA cytosine deaminase1001
Alpha-1B adrenergic receptor0404
Vpr1001
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
Voltage-dependent L-type calcium channel subunit alpha-1C0202
Dihydrofolate reductase 0101
Sodium channel protein type 2 subunit alpha0101
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 9 subunit alpha0101
Sodium channel protein type 2 subunit alpha0101
Sodium channel protein type 3 subunit alpha0101
nonstructural protein 11001
Angiotensin-converting enzyme0101
Renin 0101
interferon gamma precursor0001
Alpha-1A adrenergic receptor0224
Beta-casein0101
Interstitial collagenase0101
Matrix metalloproteinase-90101
Ribosyldihydronicotinamide dehydrogenase [quinone]0101
Alpha-2A adrenergic receptor0202
Alpha-mannosidase 2C10011
Bromodomain-containing protein 20202
3-oxo-5-alpha-steroid 4-dehydrogenase 20101
luciferase0001
Estrogen receptor0202
Glucocorticoid receptor04211
Progesterone receptor0203
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Glycine receptor subunit alpha-10404
Glutamine synthetase0011
Glycine receptor subunit beta0404
Glycine receptor subunit alpha-20404
Glycine receptor subunit alpha-30404
Histamine H1 receptor0011
Nociceptin receptor0011
Estrogen receptor beta0202
pregnane X receptor2002
thioredoxin glutathione reductase2002
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Endothelin-1 receptor0112
Neuromedin-K receptor0011
Cholecystokinin receptor type A0112
5-hydroxytryptamine receptor 70213
Nuclear receptor subfamily 2 group E member 10022
Pyruvate kinase PKM0011
Neutral amino acid transporter A0101
Neutral amino acid transporter B(0)0101
Amino acid transporter0101
cGMP-specific 3',5'-cyclic phosphodiesterase0101
Substance-P receptor0202
Neuromedin-K receptor0011
Substance-K receptor0112
Substance-K receptor0202
Substance-P receptor0213
Neuromedin-K receptor0112
Substance-K receptor0101
Substance-K receptor0101
Growth hormone secretagogue receptor type 10011
Mas-related G-protein coupled receptor member X20011
D(2) dopamine receptor0101
guanine nucleotide-binding protein subunit alpha-150112
lethal(3)malignant brain tumor-like protein 1 isoform I1001
D(3) dopamine receptor isoform e1001
trace amine-associated receptor 10112
Phenylethanolamine N-methyltransferase0101
Dopamine beta-hydroxylase 0001
Beta-secretase 10011
Trace amine-associated receptor 10011
Trace amine-associated receptor 10011
Estrogen receptor beta0101
DNA topoisomerase 10101
Estrogen receptor0101
M-phase inducer phosphatase 10101
Lysosomal alpha-glucosidase0101
Lysosomal alpha-glucosidase0101
Zinc finger protein mex-50011
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]