ketamine has been researched along with Lassitude in 11 studies
Ketamine: A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.
ketamine : A member of the class of cyclohexanones in which one of the hydrogens at position 2 is substituted by a 2-chlorophenyl group, while the other is substituted by a methylamino group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The proposed study is a single-center, phase II, randomized, double-blind, parallel-group, active-placebo-controlled trial of intravenous low-dose ketamine in patients with MS fatigue." | 9.69 | Low-dose ketamine infusion for the treatment of multiple sclerosis fatigue (INKLING-MS): Study protocol for a randomized, double-blind, active placebo-controlled phase II trial. ( Ghajarzadeh, M; Nourbakhsh, B; Roman, S; Vega, L, 2023) |
| "This study aimed at examining the effect of a single sub-anesthetic dose of ketamine on postoperative fatigue syndrome (POFS) in patients undergoing radical laparoscopic surgery for colorectal cancer (CRC)." | 9.51 | Effect of a single sub-dose of ketamine on postoperative fatigue syndrome in colorectal cancer patients undergoing radical laparoscopic surgery: A double-blind, pilot study. ( Cheng, H; Zhang, H; Zhao, L, 2022) |
| "To determine the tolerability, safety, and efficacy of low-dose ketamine infusion for MS-related fatigue." | 9.41 | Pilot randomized active-placebo-controlled trial of low-dose ketamine for the treatment of multiple sclerosis-related fatigue. ( Balshi, A; Fitzgerald, KC; Kaplin, A; Maher, D; Morris, B; Nourbakhsh, B; Soroosh, A, 2021) |
| "Compared to placebo, ketamine significantly improved fatigue (p = ." | 9.30 | Disentangling the association of depression on the anti-fatigue effects of ketamine. ( Ballard, ED; Farmer, C; Kadriu, B; Saligan, LN; Zarate, CA, 2019) |
| "The results of this pilot study are inconclusive because they lack power to support an advantage of ketamine anesthesia compared with methohexital in ameliorating depressive symptoms for electroconvulsive therapy." | 9.24 | A Randomized Pilot Study Comparing Ketamine and Methohexital Anesthesia for Electroconvulsive Therapy in Patients With Depression. ( Eads, LA; Golden, K; Han, X; Ray-Griffith, SL; Stowe, ZN, 2017) |
| "A linear mixed model showed that ketamine significantly lowered fatigue scores compared to placebo from 40 min post-treatment to Day 14 with the exception of Day 7." | 9.22 | An assessment of the anti-fatigue effects of ketamine from a double-blind, placebo-controlled, crossover study in bipolar disorder. ( Luckenbaugh, DA; Machado-Vieira, R; Saligan, LN; Slonena, EE; Zarate, CA, 2016) |
| "A low-dose ketamine infusion protocol provided significant pain relief with mostly mild side effects and no severe adverse events." | 7.81 | Low-Dose Ketamine Infusion for Emergency Department Patients with Severe Pain. ( Ahern, TL; Frazee, BW; Herring, AA; Miller, S, 2015) |
| "The proposed study is a single-center, phase II, randomized, double-blind, parallel-group, active-placebo-controlled trial of intravenous low-dose ketamine in patients with MS fatigue." | 5.69 | Low-dose ketamine infusion for the treatment of multiple sclerosis fatigue (INKLING-MS): Study protocol for a randomized, double-blind, active placebo-controlled phase II trial. ( Ghajarzadeh, M; Nourbakhsh, B; Roman, S; Vega, L, 2023) |
| "This study aimed at examining the effect of a single sub-anesthetic dose of ketamine on postoperative fatigue syndrome (POFS) in patients undergoing radical laparoscopic surgery for colorectal cancer (CRC)." | 5.51 | Effect of a single sub-dose of ketamine on postoperative fatigue syndrome in colorectal cancer patients undergoing radical laparoscopic surgery: A double-blind, pilot study. ( Cheng, H; Zhang, H; Zhao, L, 2022) |
| "To determine the tolerability, safety, and efficacy of low-dose ketamine infusion for MS-related fatigue." | 5.41 | Pilot randomized active-placebo-controlled trial of low-dose ketamine for the treatment of multiple sclerosis-related fatigue. ( Balshi, A; Fitzgerald, KC; Kaplin, A; Maher, D; Morris, B; Nourbakhsh, B; Soroosh, A, 2021) |
| "Compared to placebo, ketamine significantly improved fatigue (p = ." | 5.30 | Disentangling the association of depression on the anti-fatigue effects of ketamine. ( Ballard, ED; Farmer, C; Kadriu, B; Saligan, LN; Zarate, CA, 2019) |
| " Although low-dose ketamine demonstrates analgesic efficacy for acute pain complaints in the ED, headaches have historically been excluded from these trials." | 5.27 | Low-dose Ketamine Does Not Improve Migraine in the Emergency Department: A Randomized Placebo-controlled Trial. ( Bos, L; Etchison, AR; Heitz, C; McAllister, KB; Mohammed, M; Park, B; Phan, AV; Ray, M, 2018) |
| "The results of this pilot study are inconclusive because they lack power to support an advantage of ketamine anesthesia compared with methohexital in ameliorating depressive symptoms for electroconvulsive therapy." | 5.24 | A Randomized Pilot Study Comparing Ketamine and Methohexital Anesthesia for Electroconvulsive Therapy in Patients With Depression. ( Eads, LA; Golden, K; Han, X; Ray-Griffith, SL; Stowe, ZN, 2017) |
| "A linear mixed model showed that ketamine significantly lowered fatigue scores compared to placebo from 40 min post-treatment to Day 14 with the exception of Day 7." | 5.22 | An assessment of the anti-fatigue effects of ketamine from a double-blind, placebo-controlled, crossover study in bipolar disorder. ( Luckenbaugh, DA; Machado-Vieira, R; Saligan, LN; Slonena, EE; Zarate, CA, 2016) |
| "A low-dose ketamine infusion protocol provided significant pain relief with mostly mild side effects and no severe adverse events." | 3.81 | Low-Dose Ketamine Infusion for Emergency Department Patients with Severe Pain. ( Ahern, TL; Frazee, BW; Herring, AA; Miller, S, 2015) |
| "Esketamine was associated with significant cognitive performance impairment at 40 min postdose for all five Cogstate® tests (Detection p = 0." | 2.87 | Effect of intranasal esketamine on cognitive functioning in healthy participants: a randomized, double-blind, placebo-controlled study. ( Drevets, WC; Fedgchin, M; Lim, KS; Morrison, RL; Singh, J; van der Ark, P; Van Gerven, J; Wajs, E; Xi, L; Zannikos, P; Zuiker, R, 2018) |
| "Fifty-six young and 29 middle-aged adults who were scheduled for lower abdominal, anorectal or extremity surgery under epidural, sacral or brachial plexus blockades received intravenous analgesic or anaesthetic doses of ketamine, combined with diazepam, immediately before the start of the operation." | 1.26 | Untoward effects of ketamine combined with diazepam for supplementing conduction anaesthesia in young and middle-aged adults. ( Korttila, K; Levänen, J, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (9.09) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 7 (63.64) | 24.3611 |
| 2020's | 3 (27.27) | 2.80 |
| Authors | Studies |
|---|---|
| Zhao, L | 1 |
| Zhang, H | 1 |
| Cheng, H | 1 |
| Ghajarzadeh, M | 1 |
| Roman, S | 1 |
| Vega, L | 1 |
| Nourbakhsh, B | 2 |
| Fitzgerald, KC | 1 |
| Morris, B | 1 |
| Soroosh, A | 1 |
| Balshi, A | 1 |
| Maher, D | 1 |
| Kaplin, A | 1 |
| Ray-Griffith, SL | 1 |
| Eads, LA | 1 |
| Han, X | 1 |
| Golden, K | 1 |
| Stowe, ZN | 1 |
| Morrison, RL | 1 |
| Fedgchin, M | 1 |
| Singh, J | 1 |
| Van Gerven, J | 1 |
| Zuiker, R | 1 |
| Lim, KS | 1 |
| van der Ark, P | 1 |
| Wajs, E | 1 |
| Xi, L | 1 |
| Zannikos, P | 1 |
| Drevets, WC | 1 |
| Fallon, MT | 1 |
| Wilcock, A | 1 |
| Kelly, CA | 1 |
| Paul, J | 1 |
| Lewsley, LA | 1 |
| Norrie, J | 1 |
| Laird, BJA | 1 |
| Saligan, LN | 2 |
| Farmer, C | 1 |
| Ballard, ED | 1 |
| Kadriu, B | 1 |
| Zarate, CA | 2 |
| Etchison, AR | 1 |
| Bos, L | 1 |
| Ray, M | 1 |
| McAllister, KB | 1 |
| Mohammed, M | 1 |
| Park, B | 1 |
| Phan, AV | 1 |
| Heitz, C | 1 |
| Ahern, TL | 1 |
| Herring, AA | 1 |
| Miller, S | 1 |
| Frazee, BW | 1 |
| Luckenbaugh, DA | 1 |
| Slonena, EE | 1 |
| Machado-Vieira, R | 1 |
| Korttila, K | 1 |
| Levänen, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A PILOT STUDY OF INTRAVENOUS, SUBANESTHETIC DOSE OF KETAMINE VS PLACEBO, A CROSSOVER DESIGN, FOR MULTIPLE SCLEROSIS RELATED FATIGUE[NCT06064162] | Early Phase 1 | 20 participants (Anticipated) | Interventional | 2023-10-31 | Not yet recruiting | ||
| A Randomized, Double-blind, Placebo-controlled, 2-period Crossover Study to Evaluate the Effect of Intranasal Esketamine on Cognitive Functioning in Healthy Subjects[NCT02094378] | Phase 1 | 24 participants (Actual) | Interventional | 2014-06-30 | Completed | ||
| A Pilot Study of the Use of Oral Ketamine for Treatment of Vaso-Occlusive Pain in Adolescents and Young Adults[NCT05378555] | Phase 3 | 10 participants (Anticipated) | Interventional | 2023-05-01 | Recruiting | ||
| A Combination Study With Sub-Dissociative Ketamine and Fentanyl to Treat Moderate to Severe Pain in the Emergency Department[NCT03959852] | Phase 4 | 6 participants (Actual) | Interventional | 2019-11-18 | Terminated (stopped due to Residency completed.) | ||
| Comparison of Intravenous Push Dose of Low Dose Ketamine to Short Infusion of Low Dose Ketamine for Treatment of Moderate to Severe Pain in the Emergency Department: A Prospective, Randomized, Double-Blind Study[NCT02363270] | 48 participants (Actual) | Interventional | 2015-04-01 | Completed | |||
| Intraoperative Low-dose Ketamine Infusion as the Main Analgesic in Burn Patients[NCT03049930] | Phase 4 | 46 participants (Anticipated) | Interventional | 2018-02-27 | Recruiting | ||
| Low-Dose Ketamine Versus Morphine for Moderate to Severe Pain in the Emergency Department Geriatric Population: A Prospective, Randomized, Double-Blind Study.[NCT02673372] | Phase 4 | 60 participants (Actual) | Interventional | 2016-04-30 | Completed | ||
| A Proof-of-Concept Trial on the Effect of Ketamine on Fatigue[NCT04141696] | Phase 1/Phase 2 | 59 participants (Anticipated) | Interventional | 2021-07-26 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Overall rate of feeling of unreality as measured by Side Effects Rating Scale for Dissociative Anesthetics (SERSDA) (NCT02363270)
Timeframe: 30 minutes
| Intervention | Participants (Count of Participants) |
|---|---|
| IV Push Group | 22 |
| IV Drip Group | 13 |
The primary outcome will be the comparative reduction of NRS pain scores between the 2 groups at 30 minutes. The NRS Pain scale ranges from 0 to 10 (0 being no pain at all to 10 being very severe pain; 5 is moderate pain) (NCT02673372)
Timeframe: 30 minutes
| Intervention | score on a scale (Mean) |
|---|---|
| Morphine Group | 4.4 |
| Ketamine Group | 4.2 |
9 trials available for ketamine and Lassitude
| Article | Year |
|---|---|
Effect of a single sub-dose of ketamine on postoperative fatigue syndrome in colorectal cancer patients undergoing radical laparoscopic surgery: A double-blind, pilot study.
Topics: Anesthetics; Colorectal Neoplasms; Double-Blind Method; Fatigue; Humans; Interleukin-6; Ketamine; La | 2022 |
Low-dose ketamine infusion for the treatment of multiple sclerosis fatigue (INKLING-MS): Study protocol for a randomized, double-blind, active placebo-controlled phase II trial.
Topics: Adult; Clinical Trials, Phase II as Topic; Double-Blind Method; Fatigue; Humans; Ketamine; Midazolam | 2023 |
Pilot randomized active-placebo-controlled trial of low-dose ketamine for the treatment of multiple sclerosis-related fatigue.
Topics: Double-Blind Method; Fatigue; Humans; Ketamine; Multiple Sclerosis; Pilot Projects; Treatment Outcom | 2021 |
A Randomized Pilot Study Comparing Ketamine and Methohexital Anesthesia for Electroconvulsive Therapy in Patients With Depression.
Topics: Adult; Aged; Anesthesia; Anesthesia, Intravenous; Anesthetics, Dissociative; Anesthetics, Intravenou | 2017 |
Effect of intranasal esketamine on cognitive functioning in healthy participants: a randomized, double-blind, placebo-controlled study.
Topics: Administration, Intranasal; Adult; Cognition; Cognitive Dysfunction; Cross-Over Studies; Dizziness; | 2018 |
Oral Ketamine vs Placebo in Patients With Cancer-Related Neuropathic Pain: A Randomized Clinical Trial.
Topics: Aged; Analgesics; Antineoplastic Agents; Anxiety; Cancer Pain; Cognition Disorders; Depression; Doub | 2018 |
Disentangling the association of depression on the anti-fatigue effects of ketamine.
Topics: Adult; Antidepressive Agents; Cross-Over Studies; Depressive Disorder, Major; Depressive Disorder, T | 2019 |
Low-dose Ketamine Does Not Improve Migraine in the Emergency Department: A Randomized Placebo-controlled Trial.
Topics: Acute Pain; Adult; Anesthetics, Dissociative; Double-Blind Method; Emergency Service, Hospital; Fati | 2018 |
An assessment of the anti-fatigue effects of ketamine from a double-blind, placebo-controlled, crossover study in bipolar disorder.
Topics: Adult; Bipolar Disorder; Cross-Over Studies; Depressive Disorder, Treatment-Resistant; Double-Blind | 2016 |
2 other studies available for ketamine and Lassitude
| Article | Year |
|---|---|
Low-Dose Ketamine Infusion for Emergency Department Patients with Severe Pain.
Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Blood Pressure; Dizziness; Dose-Response Relationship, | 2015 |
Low-Dose Ketamine Infusion for Emergency Department Patients with Severe Pain.
Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Blood Pressure; Dizziness; Dose-Response Relationship, | 2015 |
Low-Dose Ketamine Infusion for Emergency Department Patients with Severe Pain.
Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Blood Pressure; Dizziness; Dose-Response Relationship, | 2015 |
Low-Dose Ketamine Infusion for Emergency Department Patients with Severe Pain.
Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Blood Pressure; Dizziness; Dose-Response Relationship, | 2015 |
Low-Dose Ketamine Infusion for Emergency Department Patients with Severe Pain.
Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Blood Pressure; Dizziness; Dose-Response Relationship, | 2015 |
Low-Dose Ketamine Infusion for Emergency Department Patients with Severe Pain.
Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Blood Pressure; Dizziness; Dose-Response Relationship, | 2015 |
Low-Dose Ketamine Infusion for Emergency Department Patients with Severe Pain.
Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Blood Pressure; Dizziness; Dose-Response Relationship, | 2015 |
Low-Dose Ketamine Infusion for Emergency Department Patients with Severe Pain.
Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Blood Pressure; Dizziness; Dose-Response Relationship, | 2015 |
Low-Dose Ketamine Infusion for Emergency Department Patients with Severe Pain.
Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Blood Pressure; Dizziness; Dose-Response Relationship, | 2015 |
Low-Dose Ketamine Infusion for Emergency Department Patients with Severe Pain.
Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Blood Pressure; Dizziness; Dose-Response Relationship, | 2015 |
Low-Dose Ketamine Infusion for Emergency Department Patients with Severe Pain.
Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Blood Pressure; Dizziness; Dose-Response Relationship, | 2015 |
Low-Dose Ketamine Infusion for Emergency Department Patients with Severe Pain.
Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Blood Pressure; Dizziness; Dose-Response Relationship, | 2015 |
Low-Dose Ketamine Infusion for Emergency Department Patients with Severe Pain.
Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Blood Pressure; Dizziness; Dose-Response Relationship, | 2015 |
Low-Dose Ketamine Infusion for Emergency Department Patients with Severe Pain.
Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Blood Pressure; Dizziness; Dose-Response Relationship, | 2015 |
Low-Dose Ketamine Infusion for Emergency Department Patients with Severe Pain.
Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Blood Pressure; Dizziness; Dose-Response Relationship, | 2015 |
Low-Dose Ketamine Infusion for Emergency Department Patients with Severe Pain.
Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Blood Pressure; Dizziness; Dose-Response Relationship, | 2015 |
Untoward effects of ketamine combined with diazepam for supplementing conduction anaesthesia in young and middle-aged adults.
Topics: Adult; Age Factors; Anesthesia, Conduction; Anesthesia, Epidural; Anxiety; Confusion; Diazepam; Dose | 1978 |