ketamine has been researched along with Spasms, Infantile in 2 studies
Ketamine: A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.
ketamine : A member of the class of cyclohexanones in which one of the hydrogens at position 2 is substituted by a 2-chlorophenyl group, while the other is substituted by a methylamino group.
Spasms, Infantile: An epileptic syndrome characterized by the triad of infantile spasms, hypsarrhythmia, and arrest of psychomotor development at seizure onset. The majority present between 3-12 months of age, with spasms consisting of combinations of brief flexor or extensor movements of the head, trunk, and limbs. The condition is divided into two forms: cryptogenic (idiopathic) and symptomatic (secondary to a known disease process such as intrauterine infections; nervous system abnormalities; BRAIN DISEASES, METABOLIC, INBORN; prematurity; perinatal asphyxia; TUBEROUS SCLEROSIS; etc.). (From Menkes, Textbook of Child Neurology, 5th ed, pp744-8)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Because both individuals' seizures had proven refractory to conventional antiepileptic medications, the sensitivity of mutant NMDARs to FDA-approved NMDAR antagonists was evaluated." | 1.43 | GRIN2D Recurrent De Novo Dominant Mutation Causes a Severe Epileptic Encephalopathy Treatable with NMDA Receptor Channel Blockers. ( Aizenman, E; Brueckner, F; Chen, W; Chiavacci, R; Elsen, G; Falk, MJ; Hakonarson, H; Hedrich, UB; Hörtnagel, K; Hu, C; Kosobucki, GJ; Kusumoto, H; Lemke, JR; Li, D; Marsh, ED; McCormick, EM; Naase, C; Ortiz-Gonzalez, XR; Schulien, AJ; Tankovic, A; Tian, L; Traynelis, SF; von Stülpnagel-Steinbeis, C; Yuan, H, 2016) |
| "Glycine is a major inhibitory neurotransmitter in the CNS, but has also modulating effects at one of the glutamate receptors, the N-methyl-D-aspartate-(NMDA) receptor." | 1.29 | Ketamine and strychnine treatment of an infant with nonketotic hyperglycinaemia. ( Adams, HA; Günther, M; Heinemann, U; Roth, B; Sticht, G; Tegtmeyer-Metzdorf, H; Theisohn, M, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Li, D | 1 |
| Yuan, H | 1 |
| Ortiz-Gonzalez, XR | 1 |
| Marsh, ED | 1 |
| Tian, L | 1 |
| McCormick, EM | 1 |
| Kosobucki, GJ | 1 |
| Chen, W | 1 |
| Schulien, AJ | 1 |
| Chiavacci, R | 1 |
| Tankovic, A | 1 |
| Naase, C | 1 |
| Brueckner, F | 1 |
| von Stülpnagel-Steinbeis, C | 1 |
| Hu, C | 1 |
| Kusumoto, H | 1 |
| Hedrich, UB | 1 |
| Elsen, G | 1 |
| Hörtnagel, K | 1 |
| Aizenman, E | 1 |
| Lemke, JR | 1 |
| Hakonarson, H | 1 |
| Traynelis, SF | 1 |
| Falk, MJ | 1 |
| Tegtmeyer-Metzdorf, H | 1 |
| Roth, B | 1 |
| Günther, M | 1 |
| Theisohn, M | 1 |
| Heinemann, U | 1 |
| Adams, HA | 1 |
| Sticht, G | 1 |
2 other studies available for ketamine and Spasms, Infantile
| Article | Year |
|---|---|
GRIN2D Recurrent De Novo Dominant Mutation Causes a Severe Epileptic Encephalopathy Treatable with NMDA Receptor Channel Blockers.
Topics: Amino Acid Sequence; Base Sequence; Cell Death; Child; Dendrites; DNA Mutational Analysis; Electroen | 2016 |
Ketamine and strychnine treatment of an infant with nonketotic hyperglycinaemia.
Topics: Amino Acid Metabolism, Inborn Errors; Chromosome Aberrations; Chromosome Disorders; Drug Therapy, Co | 1995 |