ketamine has been researched along with Reflex, Abnormal in 6 studies
Ketamine: A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.
ketamine : A member of the class of cyclohexanones in which one of the hydrogens at position 2 is substituted by a 2-chlorophenyl group, while the other is substituted by a methylamino group.
Reflex, Abnormal: An abnormal response to a stimulus applied to the sensory components of the nervous system. This may take the form of increased, decreased, or absent reflexes.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Melatonin pretreatment caused rapid onset of anesthesia after ketamine and thiopental sodium administration while the duration of action of these agents was prolonged." | 5.33 | Adjuvant effect of melatonin on anesthesia induced by thiopental sodium, ketamine, and ether in rats. ( Budhiraja, S; Singh, J, 2005) |
| "Melatonin pretreatment caused rapid onset of anesthesia after ketamine and thiopental sodium administration while the duration of action of these agents was prolonged." | 1.33 | Adjuvant effect of melatonin on anesthesia induced by thiopental sodium, ketamine, and ether in rats. ( Budhiraja, S; Singh, J, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sullivan, RW | 1 |
| Ryzewski, M | 1 |
| Holland, MG | 1 |
| Marraffa, JM | 1 |
| González Gil, A | 1 |
| Illera, JC | 1 |
| Silván, G | 1 |
| Illera, M | 1 |
| Baba, M | 1 |
| Budhiraja, S | 1 |
| Singh, J | 1 |
| Taylor, J | 1 |
| Munson, J | 1 |
| Vierck, C | 1 |
| Mantz, J | 1 |
| Chéramy, A | 1 |
| Thierry, AM | 1 |
| Glowinski, J | 1 |
| Desmonts, JM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Antipruritic Effect of Topical Ketamine, Amitriptyline, and Lidocaine[NCT03096444] | Phase 2 | 13 participants (Actual) | Interventional | 2017-05-23 | Terminated (stopped due to Efficacy was not seen after interim analysis) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Peak itch intensity between the vehicle and 4 other active treatments (individual ketamine, amitriptyline, or lidocaine, and KeAmLi-combo). Itch intensity was measured on a 100mm scale visual analog scale for 10 minutes. 0 was weighted with no itch and 100 was weighted with most itch imaginable." (NCT03096444)
Timeframe: 10 minutes
| Intervention | Intensity score (Mean) |
|---|---|
| Topical KeAmLi Combo | 62.7 |
| Topical Ketamine | 63.1 |
| Topical Amitriptyline | 69.2 |
| Topical Lidocaine | 65.8 |
| Topical Vehicle | 61.9 |
Assess mechanical detection and pain thresholds using von Frey filaments stimulators (measured in force mN) to calculate the final threshold as the geometric mean of five series of ascending and descending stimuli. (NCT03096444)
Timeframe: 5 minutes
| Intervention | mN (Mean) | |
|---|---|---|
| Mechanical Detection Threshold | Mechanical Pain Threshold | |
| Topical Amitriptyline | 3.573423965 | 152.4768146 |
| Topical KeAmLi Combo | 3.519376956 | 152.3293608 |
| Topical Ketamine | 3.464204768 | 135.9 |
| Topical Lidocaine | 3.546037659 | 126.9 |
| Topical Vehicle | 3.525692637 | 148.7138273 |
Two standardized quantitative sensory tests are performed to measure warmth detection threshold (assesses the threshold of which warmth sensation is first detected) and heat pain threshold (assesses the threshold at which heat pain sensation is first detected). Measured in change in celsius. (NCT03096444)
Timeframe: 3 minutes
| Intervention | Degrees celsius (Mean) | |
|---|---|---|
| Warm Detection Threshold | Heat Pain Threshold | |
| Topical Amitriptyline | 33.9 | 40.0 |
| Topical KeAmLi Combo | 33.6 | 39.8 |
| Topical Ketamine | 34.0 | 40.0 |
| Topical Lidocaine | 33.7 | 39.4 |
| Topical Vehicle | 33.8 | 39.7 |
1 review available for ketamine and Reflex, Abnormal
| Article | Year |
|---|---|
[Progress in diagnosis of and therapy for diabetic polyneuropathies].
Topics: Achilles Tendon; Aldehyde Reductase; Antidepressive Agents, Tricyclic; Diabetic Neuropathies; Diagno | 2004 |
5 other studies available for ketamine and Reflex, Abnormal
| Article | Year |
|---|---|
Compounded ointment results in severe toxicity in a pediatric patient.
Topics: Administration, Cutaneous; Amines; Analgesics; Body Surface Area; Bradycardia; Clonidine; Combined M | 2013 |
Effects of the anaesthetic/tranquillizer treatments on selected plasma biochemical parameters in NZW rabbits.
Topics: Adjuvants, Anesthesia; Adrenergic alpha-Antagonists; Anesthetics; Animals; Biomarkers; Blood Chemica | 2003 |
Adjuvant effect of melatonin on anesthesia induced by thiopental sodium, ketamine, and ether in rats.
Topics: Adjuvants, Anesthesia; Anesthesia; Anesthetics, Combined; Anesthetics, Dissociative; Anesthetics, In | 2005 |
Effects of dorsolateral spinal lesions on stretch reflex threshold and stiffness in awake cats.
Topics: Anesthetics, Dissociative; Animals; Cats; Electromyography; Female; Ketamine; Muscle Spasticity; Mus | 1999 |
Anesthetic properties of riluzole (54274 RP), a new inhibitor of glutamate neurotransmission.
Topics: Anesthetics; Animals; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Ant | 1992 |