ketamine has been researched along with Chemical and Drug Induced Liver Injury in 19 studies
Ketamine: A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.
ketamine : A member of the class of cyclohexanones in which one of the hydrogens at position 2 is substituted by a 2-chlorophenyl group, while the other is substituted by a methylamino group.
Chemical and Drug Induced Liver Injury: A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Urological toxicity, hepatotoxicity and cognitive deficits are all reported as adverse effects of the recreational use of ketamine." | 2.48 | Ketamine for chronic noncancer pain: concerns regarding toxicity. ( Bell, RF, 2012) |
| "Ketamine is a commonly abused recreational drug in Southeast Asia." | 1.40 | Ketamine-related cholangiopathy: a retrospective study on clinical and imaging findings. ( Ahuja, AT; Chan, AW; Chau, HH; Cho, CC; Hui, JW; Hung, EH; Lung, PF; Yu, WL, 2014) |
| " We proposed a systematic classification scheme using FDA-approved drug labeling to assess the DILI potential of drugs, which yielded a benchmark dataset with 287 drugs representing a wide range of therapeutic categories and daily dosage amounts." | 1.37 | FDA-approved drug labeling for the study of drug-induced liver injury. ( Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V, 2011) |
| "Ketamine has been shown to prevent these effects." | 1.35 | Ketamine-induced hepatoprotection: the role of heme oxygenase-1. ( Adams, SD; Helmer, KS; Mercer, DW; Suliburk, JW; Ward, JL; Zuckerbraun, BS, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (5.26) | 18.2507 |
| 2000's | 1 (5.26) | 29.6817 |
| 2010's | 14 (73.68) | 24.3611 |
| 2020's | 3 (15.79) | 2.80 |
| Authors | Studies |
|---|---|
| Fourches, D | 1 |
| Barnes, JC | 1 |
| Day, NC | 1 |
| Bradley, P | 1 |
| Reed, JZ | 1 |
| Tropsha, A | 1 |
| Morgan, RE | 2 |
| Trauner, M | 1 |
| van Staden, CJ | 2 |
| Lee, PH | 1 |
| Ramachandran, B | 1 |
| Eschenberg, M | 1 |
| Afshari, CA | 2 |
| Qualls, CW | 1 |
| Lightfoot-Dunn, R | 1 |
| Hamadeh, HK | 2 |
| Chen, M | 2 |
| Vijay, V | 1 |
| Shi, Q | 2 |
| Liu, Z | 2 |
| Fang, H | 2 |
| Tong, W | 3 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Chen, Y | 1 |
| Kalyanaraman, N | 1 |
| Kalanzi, J | 1 |
| Dunn, RT | 1 |
| Suzuki, A | 1 |
| Thakkar, S | 1 |
| Yu, K | 1 |
| Hu, C | 1 |
| Chen, FH | 1 |
| Yu, CF | 1 |
| Yang, CL | 1 |
| Lin, YC | 1 |
| Lin, G | 1 |
| Wang, CC | 1 |
| Yu, HP | 1 |
| Fang, J | 1 |
| Chang, NF | 1 |
| Hong, JH | 1 |
| Zhu, X | 1 |
| Kohan, LR | 1 |
| Goldstein, RB | 1 |
| Xu, W | 1 |
| Wang, P | 1 |
| Wang, D | 1 |
| Liu, K | 1 |
| Zhang, S | 1 |
| Zhao, W | 1 |
| Liu, G | 1 |
| Nanagas, K | 1 |
| Avera, R | 1 |
| Purpura, A | 1 |
| Murphy, J | 1 |
| Kao, L | 1 |
| Wong, GL | 1 |
| Tam, YH | 1 |
| Ng, CF | 1 |
| Chan, AW | 2 |
| Choi, PC | 1 |
| Chu, WC | 1 |
| Lai, PB | 1 |
| Chan, HL | 1 |
| Wong, VW | 1 |
| Yu, WL | 1 |
| Cho, CC | 1 |
| Lung, PF | 1 |
| Hung, EH | 1 |
| Hui, JW | 1 |
| Chau, HH | 1 |
| Ahuja, AT | 1 |
| Suliburk, JW | 1 |
| Ward, JL | 1 |
| Helmer, KS | 1 |
| Adams, SD | 1 |
| Zuckerbraun, BS | 1 |
| Mercer, DW | 1 |
| Noppers, IM | 1 |
| Niesters, M | 1 |
| Aarts, LPHJ | 1 |
| Bauer, MCR | 1 |
| Drewes, AM | 1 |
| Dahan, A | 1 |
| Sarton, EY | 1 |
| Sear, JW | 1 |
| Westerling, D | 1 |
| Lindblom, P | 1 |
| Bell, RF | 1 |
| Kalkan, Y | 1 |
| Tomak, Y | 1 |
| Altuner, D | 1 |
| Tumkaya, L | 1 |
| Bostan, H | 1 |
| Yilmaz, A | 1 |
| Unal, D | 1 |
| Kara, A | 1 |
| Turan, A | 1 |
| Kato, Y | 1 |
| Homma, I | 1 |
| Ichiyanagi, K | 1 |
2 reviews available for ketamine and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Pr | 2016 |
Ketamine for chronic noncancer pain: concerns regarding toxicity.
Topics: Analgesics; Chemical and Drug Induced Liver Injury; Chronic Pain; Cognition Disorders; Dose-Response | 2012 |
1 trial available for ketamine and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
Drug-induced liver injury following a repeated course of ketamine treatment for chronic pain in CRPS type 1 patients: a report of 3 cases.
Topics: Adult; Aged; Chemical and Drug Induced Liver Injury; Female; Humans; Ketamine; Male; Middle Aged; Pi | 2011 |
16 other studies available for ketamine and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2010 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Des | 2011 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily | 2013 |
Multimodal imaging reveals transient liver metabolic disturbance and sinusoidal circulation obstruction after a single administration of ketamine/xylazine mixture.
Topics: Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Ketamine; Liver; Magne | 2020 |
Substantial Elevation of Liver Enzymes During Ketamine Infusion: A Case Report.
Topics: Analgesics; Chemical and Drug Induced Liver Injury; Complex Regional Pain Syndromes; Female; Humans; | 2020 |
S-ketamine alleviates carbon tetrachloride-induced hepatic injury and oxidative stress by targeting the Nrf2/HO-1 signaling pathway.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Heme Oxygenase (Decyclizing); | 2021 |
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Topics: Alcohol Withdrawal Delirium; Antidotes; Carbon Monoxide Poisoning; Chemical and Drug Induced Liver I | 2018 |
Liver injury is common among chronic abusers of ketamine.
Topics: Adult; Bile Ducts; Biopsy; Chemical and Drug Induced Liver Injury; Cholangiopancreatography, Magneti | 2014 |
Ketamine-related cholangiopathy: a retrospective study on clinical and imaging findings.
Topics: Adult; Bile Duct Diseases; Bile Ducts; Chemical and Drug Induced Liver Injury; Cholangiography; Chol | 2014 |
Ketamine-induced hepatoprotection: the role of heme oxygenase-1.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbon Monoxide; Chemical an | 2009 |
Ketamine hepato-toxicity in chronic pain management: another example of unexpected toxicity or a predicted result from previous clinical and pre-clinical data?
Topics: Chemical and Drug Induced Liver Injury; Female; Humans; Ketamine; Male; Reflex Sympathetic Dystrophy | 2011 |
Re: Noppers et al., Drug-induced liver injury following a reported course of ketamine treatment for chronic pain in CRPS type I patients. A report on 3 cases. Pain 2011;152:2173-8.
Topics: Chemical and Drug Induced Liver Injury; Female; Humans; Ketamine; Male; Reflex Sympathetic Dystrophy | 2012 |
Hepatic effects of ketamine administration for 2 weeks in rats.
Topics: Analgesics; Anesthetics, Dissociative; Animals; Apoptosis; Calcineurin; Calcineurin Inhibitors; Chem | 2014 |
Postherpetic neuralgia.
Topics: Aged; Aged, 80 and over; Chemical and Drug Induced Liver Injury; Female; Herpesviridae Infections; H | 1995 |