Page last updated: 2024-09-27

Anesthesia Awareness

Occurence of a patient becoming conscious during a procedure performed under GENERAL ANESTHESIA and subsequently having recall of these events. (From Anesthesiology 2006, 104(4): 847-64.)

Synonyms(3)

Synonym
Intraoperative Awareness
Awareness During Anesthesia
Anesthesia Awareness

Research Excerpts

Overview

ExcerptReference
"The prevention of intraoperative awareness is another major consideration."( Lesage, S, 2014)
"Intraoperative awareness is a rarely occurring phenomenon."( GaszyƄski, T; Wieczorek, A, 2016)

Research

Studies (70)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's0 (0.00)18.1394
2010's66 (94.29)28.8240
2020's4 (5.71)9.53
DrugIndicatedRelationship StrengthStudiesTrials
gamma-aminobutyric acid0low10
nitrous oxide0low80
amantadine0low10
chloral hydrate0low10
fentanyl0medium42
gabapentin0low10
isoflurane0medium82
ketamine0low20
midazolam0medium21
apnea0low30
neostigmine0medium11
propofol0medium249
propranolol0low10
sevoflurane0medium165
succinylcholine0medium31
levodopa0low10
methionine0low10
quinuclidines0medium21
pyridostigmine bromide0medium11
xenon0medium11
magnesium sulfate0medium11
sufentanil0medium22
desflurane0medium33
atracurium0medium32
fomesafen0low20
remifentanil0medium84
cisatracurium0medium32
homocysteine0low10
carbidopa, levodopa drug combination0low10
m 82180medium21
rocuronium0low20
etomidate0low10
thiopental0low80
mivacurium0low20
dexmedetomidine0medium31
piperidines0medium84
carbidopa0low10

Protein Targets (406)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
acetylcholinesterase2002
thioredoxin reductase6006
RAR-related orphan receptor gamma4004
NFKB1 protein, partial1001
GLI family zinc finger 32002
AR protein4004
signal transducer and activator of transcription 6, interleukin-4 induced1001
thyroid stimulating hormone receptor5005
regulator of G-protein signaling 44004
EWS/FLI fusion protein4004
estrogen nuclear receptor alpha6006
putative alpha-glucosidase1001
euchromatic histone-lysine N-methyltransferase 2130013
thyroid hormone receptor beta isoform 22002
heat shock protein beta-12002
peripheral myelin protein 227007
histone acetyltransferase KAT2A isoform 13003
lamin isoform A-delta10100010
Solute carrier family 22 member 20102
Solute carrier family 22 member 1 0405
Glutamate receptor ionotropic, NMDA 2D0202
Glutamate receptor ionotropic, NMDA 3B0202
Matrix protein 20112
Matrix protein 20123
Glutamate receptor ionotropic, NMDA 1 0304
Spike glycoprotein3003
Glutamate receptor ionotropic, NMDA 2A 0304
Glutamate receptor ionotropic, NMDA 2B0304
Glutamate receptor ionotropic, NMDA 2C0304
Glutamate receptor ionotropic, NMDA 10303
Glutamate receptor ionotropic, NMDA 2A0303
Glutamate receptor ionotropic, NMDA 2B0303
Glutamate receptor ionotropic, NMDA 2C0202
Glutamate receptor ionotropic, NMDA 2D0304
Solute carrier family 22 member 10101
Glutamate receptor ionotropic, NMDA 3A0202
Glutamate receptor ionotropic, NMDA 3B0304
Multidrug and toxin extrusion protein 10101
Solute carrier family 22 member 20101
Glutamate receptor ionotropic, NMDA 3A0304
ATP-dependent phosphofructokinase3003
ATAD5 protein, partial2002
TDP1 protein3003
Microtubule-associated protein tau1001
estrogen-related nuclear receptor alpha4004
arylsulfatase A5005
Bloom syndrome protein isoform 15005
D(1A) dopamine receptor5005
neuropeptide S receptor isoform A2002
NPYLR7B0011
Amine oxidase [flavin-containing] A 0011
Small conductance calcium-activated potassium channel protein 30112
glucocorticoid receptor [Homo sapiens]4004
retinoid X nuclear receptor alpha1001
peroxisome proliferator-activated receptor delta2002
Alpha-1B adrenergic receptor 0011
cytochrome P450 2D6 isoform 11001
cellular tumor antigen p53 isoform a1001
cytochrome P450 2C19 precursor1001
cytochrome P450 2C9 precursor1001
cytochrome P450 3A4 isoform 13003
Gamma-aminobutyric acid receptor subunit pi36211
Alpha-2A adrenergic receptor0236
Gamma-aminobutyric acid receptor subunit beta-136211
Alpha-1B adrenergic receptor0213
Alpha-1A adrenergic receptor0011
Gamma-aminobutyric acid receptor subunit delta36211
Gamma-aminobutyric acid receptor subunit gamma-236312
Alpha-2C adrenergic receptor0236
Alpha-2B adrenergic receptor0112
Gamma-aminobutyric acid receptor subunit alpha-536211
Gamma-aminobutyric acid receptor subunit alpha-336211
Alpha-2C adrenergic receptor0112
Alpha-2A adrenergic receptor0112
Gamma-aminobutyric acid receptor subunit gamma-136211
Gamma-aminobutyric acid receptor subunit alpha-236211
Alpha-1D adrenergic receptor0213
Alpha-1D adrenergic receptor0113
Gamma-aminobutyric acid receptor subunit alpha-436211
Gamma-aminobutyric acid receptor subunit gamma-336211
Gamma-aminobutyric acid receptor subunit alpha-636211
Alpha-1A adrenergic receptor0213
Histamine H2 receptor1001
Gamma-aminobutyric acid receptor subunit alpha-136312
Gamma-aminobutyric acid receptor subunit beta-336211
Gamma-aminobutyric acid receptor subunit beta-236312
GABA theta subunit36211
Gamma-aminobutyric acid receptor subunit epsilon36211
lethal factor (plasmid)1001
Bile salt export pump0808
Acetylcholine receptor subunit alpha0101
Acetylcholine receptor subunit beta0101
Acetylcholine receptor subunit gamma0101
Acetylcholine receptor subunit delta0101
Acetylcholine receptor subunit delta0101
Acetylcholine receptor subunit alpha0101
Acetylcholine receptor subunit gamma0101
Acetylcholine receptor subunit beta0101
Gamma-aminobutyric acid receptor subunit alpha-10336
Cytochrome P450 11B1, mitochondrial0101
Gamma-aminobutyric acid receptor subunit gamma-20336
Cytochrome P450 11B2, mitochondrial0101
Gamma-aminobutyric acid receptor subunit alpha-20134
Gamma-aminobutyric acid receptor subunit beta-20235
Transporter0101
Luciferase3003
cytochrome P450 family 3 subfamily A polypeptide 43003
pregnane X nuclear receptor4004
potassium voltage-gated channel subfamily H member 2 isoform d1001
Nuclear receptor subfamily 1 group I member 20011
ATP-dependent translocase ABCB10505
D(2) dopamine receptor0213
Amine oxidase [flavin-containing] A0101
D(4) dopamine receptor0101
Amine oxidase [flavin-containing] B0101
Delta-type opioid receptor0202
Delta-type opioid receptor0303
Mu-type opioid receptor0516
Kappa-type opioid receptor0202
Histamine H1 receptor0101
Mu-type opioid receptor0336
D(3) dopamine receptor0101
Delta-type opioid receptor0314
Kappa-type opioid receptor0202
Kappa-type opioid receptor0314
Mu-type opioid receptor0101
Mu-type opioid receptor0202
Potassium voltage-gated channel subfamily H member 20202
Sigma non-opioid intracellular receptor 10404
Sigma non-opioid intracellular receptor 10404
Sigma non-opioid intracellular receptor 10101
hypoxia-inducible factor 1 alpha subunit1001
progesterone receptor2002
peroxisome proliferator activated receptor gamma1001
vitamin D (1,25- dihydroxyvitamin D3) receptor2002
Histone H2A.x2002
nuclear factor erythroid 2-related factor 2 isoform 11001
USP1 protein, partial3003
thioredoxin glutathione reductase1001
aldehyde dehydrogenase 1 family, member A11001
ubiquitin carboxyl-terminal hydrolase 2 isoform a2002
survival motor neuron protein isoform d1001
muscarinic acetylcholine receptor M14004
Voltage-dependent calcium channel subunit alpha-2/delta-10101
Chain A, Ferritin light chain3003
Gamma-aminobutyric acid 0011
Gamma-aminobutyric acid receptor subunit rho-30011
Hsf1 protein0011
bromodomain adjacent to zinc finger domain 2B1001
thyroid hormone receptor beta isoform a1001
transcriptional regulator ERG isoform 31001
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
geminin5005
Gamma-aminobutyric acid receptor subunit pi0101
Gamma-aminobutyric acid receptor subunit delta0101
Histone deacetylase 30101
Gamma-aminobutyric acid type B receptor subunit 20011
Gamma-aminobutyric acid type B receptor subunit 20101
Gamma-aminobutyric acid receptor subunit alpha-60011
Gamma-aminobutyric acid receptor subunit beta-10123
Gamma-aminobutyric acid receptor subunit gamma-20011
Gamma-aminobutyric acid receptor subunit delta0011
Sodium- and chloride-dependent GABA transporter 10303
Gamma-aminobutyric acid receptor subunit rho-10022
Gamma-aminobutyric acid receptor subunit alpha-20011
Gamma-aminobutyric acid receptor subunit alpha-30011
Gamma-aminobutyric acid receptor subunit gamma-30011
Gamma-aminobutyric acid receptor subunit beta-30224
Gamma-aminobutyric acid receptor subunit rho-20011
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent taurine transporter0101
Gamma-aminobutyric acid receptor subunit alpha-50123
Sodium- and chloride-dependent GABA transporter 20303
Sodium- and chloride-dependent GABA transporter 30303
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Gamma-aminobutyric acid receptor subunit alpha-30123
Sodium- and chloride-dependent betaine transporter0303
Sodium- and chloride-dependent betaine transporter0101
Sodium- and chloride-dependent GABA transporter 30101
Gamma-aminobutyric acid receptor subunit alpha-40123
Gamma-aminobutyric acid receptor subunit beta-10011
Histone deacetylase 40101
Gamma-aminobutyric acid receptor subunit alpha-10011
Gamma-aminobutyric acid receptor subunit beta-30011
Gamma-aminobutyric acid receptor subunit epsilon0101
4-aminobutyrate aminotransferase, mitochondrial0001
4-aminobutyrate aminotransferase, mitochondrial0001
TAR DNA-binding protein 431001
Histone deacetylase 10101
Gamma-aminobutyric acid receptor subunit alpha-60123
Sterol O-acyltransferase 10011
Proton-coupled amino acid transporter 10101
Gamma-aminobutyric acid receptor subunit alpha-50011
Gamma-aminobutyric acid receptor subunit gamma-10101
Gamma-aminobutyric acid receptor subunit pi0011
Histone deacetylase 70101
Histone deacetylase 20101
Polyamine deacetylase HDAC100101
Histone deacetylase 11 0101
Gamma-aminobutyric acid receptor subunit gamma-30101
Histone deacetylase 80101
Gamma-aminobutyric acid receptor subunit alpha-40011
Platelet glycoprotein VI0011
Gamma-aminobutyric acid receptor subunit theta0011
Sodium- and chloride-dependent GABA transporter 20101
Gamma-aminobutyric acid receptor subunit gamma-10011
Histone deacetylase 60101
Gamma-aminobutyric acid type B receptor subunit 10011
Histone deacetylase 90101
Gamma-aminobutyric acid receptor subunit theta0101
Histone deacetylase 50101
Gamma-aminobutyric acid type B receptor subunit 10101
N(G),N(G)-dimethylarginine dimethylaminohydrolase 10101
retinoic acid nuclear receptor alpha variant 12002
Cellular tumor antigen p532002
Neuronal acetylcholine receptor subunit beta-20101
Neuronal acetylcholine receptor subunit alpha-70101
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE3003
chromobox protein homolog 12002
ATP-binding cassette sub-family C member 30404
Multidrug resistance-associated protein 40404
Acetylcholinesterase0202
Rap guanine nucleotide exchange factor 31001
Sodium channel protein type 4 subunit alpha0101
Cholinesterase0202
Canalicular multispecific organic anion transporter 10404
Chain A, TYROSYL-DNA PHOSPHODIESTERASE1001
Chain A, HADH2 protein1001
Chain B, HADH2 protein1001
Chain A, JmjC domain-containing histone demethylation protein 3A1001
Chain A, 2-oxoglutarate Oxygenase1001
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
dopamine D1 receptor1001
15-lipoxygenase, partial1001
WRN1001
integrase, partial0101
lens epithelium-derived growth factor p750101
phosphopantetheinyl transferase1001
GLS protein3003
apical membrane antigen 1, AMA11001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)2002
pyruvate kinase1001
hexokinase-4 isoform 11001
atrial natriuretic peptide receptor 1 precursor1001
glucokinase regulatory protein1001
importin subunit beta-1 isoform 11001
flap endonuclease 11001
snurportin-11001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
DNA polymerase eta isoform 11001
DNA polymerase iota isoform a (long)2002
DNA polymerase kappa isoform 11001
M-phase phosphoprotein 82002
Polyphenol oxidase 20001
Carbonic anhydrase 120001
Epidermal growth factor receptor0101
Carbonic anhydrase 10102
Carbonic anhydrase 20102
Plasma kallikrein0001
Tyrosine-protein kinase Lck0101
Tyrosine-protein kinase Fyn0101
Carbonic anhydrase 30001
Polyunsaturated fatty acid lipoxygenase ALOX150202
Tyrosinase0101
Carbonic anhydrase 40001
Carbonic anhydrase 60001
Adenosine receptor A10001
Adenosine receptor A2a0001
Carbonic anhydrase 5A, mitochondrial0001
Carbonic anhydrase0001
Carbonic anhydrase 70001
Solute carrier family 15 member 10101
Carbonic anhydrase0001
Large neutral amino acids transporter small subunit 10202
SLC16A10 protein0001
Carbonic anhydrase 90001
Carbonic anhydrase 0001
Carbonic anhydrase-like protein, putative0001
Carbonic anhydrase0001
Carbonic anhydrase0001
Carbonic anhydrase 0001
Monocarboxylate transporter 100001
Carbonic anhydrase 150001
Carbonic anhydrase 130001
Carbonic anhydrase 140001
Carbonic anhydrase 5B, mitochondrial0001
phosphoglycerate kinase1001
Chain A, Methionyl-tRNA synthetase0011
Chain A, Methionyl-tRNA synthetase0011
Chain A, Aminopeptidase0101
Chain A, Methionine aminopeptidase0101
S-ribosylhomocysteine lyase0101
Adenylate cyclase type 50001
S-adenosylmethionine synthase isoform type-10001
S-adenosylmethionine synthase isoform type-20001
Fatty acid synthase0101
ATP-dependent translocase ABCB10101
Cytochrome P450 3A40202
Translocator protein0101
UDP-glucuronosyltransferase 2B70101
UDP-glucuronosyltransferase 1-60101
ATP-dependent translocase ABCB10101
UDP-glucuronosyltransferase 1A1 0101
UDP-glucuronosyltransferase 1A40101
UDP-glucuronosyltransferase 2B10 0101
Cholinesterase0202
Acetylcholinesterase0303
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
caspase 7, apoptosis-related cysteine protease1001
farnesoid X nuclear receptor1001
G1001
caspase-31001
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a1001
activating transcription factor 61001
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a1001
v-jun sarcoma virus 17 oncogene homolog (avian)1001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 11001
Fatty-acid amide hydrolase 10101
UDP-glucuronosyltransferase 1A90001
5-hydroxytryptamine receptor 40404
Interferon beta1001
HLA class I histocompatibility antigen, B alpha chain 1001
Aldo-keto reductase family 1 member B10202
Gamma-aminobutyric acid receptor subunit alpha-10002
Gamma-aminobutyric acid receptor subunit beta-10002
Gamma-aminobutyric acid receptor subunit alpha-20002
Gamma-aminobutyric acid receptor subunit alpha-30002
Gamma-aminobutyric acid receptor subunit alpha-40002
Gamma-aminobutyric acid receptor subunit gamma-20002
Prostaglandin G/H synthase 10101
Sodium-dependent noradrenaline transporter 0202
5-hydroxytryptamine receptor 2C0415
5-hydroxytryptamine receptor 2B0415
Fatty-acid amide hydrolase 10202
Inositol hexakisphosphate kinase 11001
UDP-glucuronosyltransferase 1A80001
cytochrome P450 2C9, partial1001
Beta-1 adrenergic receptor 0113
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Bile salt export pump0101
Albumin0011
Cytochrome P450 1A20101
Beta-2 adrenergic receptor0213
Muscarinic acetylcholine receptor M20112
Beta-1 adrenergic receptor0213
5-hydroxytryptamine receptor 1A0101
Adenosine receptor A30112
Beta-2 adrenergic receptor0203
Cytochrome P450 2C80101
Cytochrome P450 2D60101
Muscarinic acetylcholine receptor M10112
Cytochrome P450 2C9 0101
Beta-3 adrenergic receptor0213
Alpha-2B adrenergic receptor0012
Beta-1 adrenergic receptor0214
D(3) dopamine receptor0101
5-hydroxytryptamine receptor 1A0214
Muscarinic acetylcholine receptor M30112
D(1A) dopamine receptor0112
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Endothelin-1 receptor0112
Beta-3 adrenergic receptor0202
5-hydroxytryptamine receptor 1B0213
5-hydroxytryptamine receptor 2A0213
5-hydroxytryptamine receptor 1B0202
Adenosine receptor A2a0112
Neuromedin-K receptor0011
Type-1 angiotensin II receptor0112
Sodium-dependent serotonin transporter0202
Cholecystokinin receptor type A0112
Cytochrome P450 2C190101
5-hydroxytryptamine receptor 70112
Beta-1 adrenergic receptor0101
Alpha-1A adrenergic receptor0124
Alpha-1B adrenergic receptor0012
Vasopressin V1a receptor0112
5-hydroxytryptamine receptor 60213
5-hydroxytryptamine receptor 70101
Cytochrome P450 2J20101
Beta-2 adrenergic receptor0101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Sodium channel protein type 5 subunit alpha0101
Sodium/bile acid cotransporter0101
Beta-2 adrenergic receptor0113
Ataxin-21001
Nuclear receptor subfamily 2 group E member 10022
Chain A, Beta-lactamase1001
endonuclease IV1001
alpha-galactosidase1001
nuclear receptor ROR-gamma isoform 11001
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Acetylcholinesterase0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]