ketamine has been researched along with Autism Spectrum Disorder in 8 studies
Ketamine: A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.
ketamine : A member of the class of cyclohexanones in which one of the hydrogens at position 2 is substituted by a 2-chlorophenyl group, while the other is substituted by a methylamino group.
Autism Spectrum Disorder: Wide continuum of associated cognitive and neurobehavioral disorders, including, but not limited to, three core-defining features: impairments in socialization, impairments in verbal and nonverbal communication, and restricted and repetitive patterns of behaviors. (from DSM-V)
| Excerpt | Relevance | Reference |
|---|---|---|
| "We describe an episode of apnea, a rare adverse event of ketamine, which was given for procedural sedation to a severely malnourished 13-year-old female with anorexia nervosa, generalized anxiety disorder, and high-functioning autism spectrum disorder." | 8.12 | Apnea with ketamine sedation in a patient with severe anorexia nervosa: A case report. ( Joshi, R; Marvin, W, 2022) |
| "We describe an episode of apnea, a rare adverse event of ketamine, which was given for procedural sedation to a severely malnourished 13-year-old female with anorexia nervosa, generalized anxiety disorder, and high-functioning autism spectrum disorder." | 4.12 | Apnea with ketamine sedation in a patient with severe anorexia nervosa: A case report. ( Joshi, R; Marvin, W, 2022) |
| "Autism or autism spectrum disorder (ASD) is a behavioral syndrome characterized by persistent deficits in social interaction, and repetitive patterns of behavior, interests, or activities." | 1.72 | Autistic-like social deficits in hippocampal MeCP2 knockdown rat models are rescued by ketamine. ( Choi, M; Chung, H; Kim, DG; Ko, SY; Lee, H; Seo, JY; Son, H, 2022) |
| "Ketamine was most commonly given intravenously (71." | 1.51 | Procedural sedation in children with autism spectrum disorders in the emergency department. ( Brown, JJ; Farooqi, A; Gray, JM; Kannikeswaran, N; Roback, MG; Sethuraman, U, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (37.50) | 24.3611 |
| 2020's | 5 (62.50) | 2.80 |
| Authors | Studies |
|---|---|
| Özgen, MH | 1 |
| van den Brink, W | 1 |
| Choi, M | 1 |
| Ko, SY | 1 |
| Seo, JY | 1 |
| Kim, DG | 1 |
| Lee, H | 1 |
| Chung, H | 1 |
| Son, H | 1 |
| Bove, M | 1 |
| Schiavone, S | 1 |
| Tucci, P | 1 |
| Sikora, V | 1 |
| Dimonte, S | 1 |
| Colia, AL | 1 |
| Morgese, MG | 1 |
| Trabace, L | 1 |
| Wink, LK | 1 |
| Reisinger, DL | 1 |
| Horn, P | 1 |
| Shaffer, RC | 1 |
| O'Brien, K | 1 |
| Schmitt, L | 1 |
| Dominick, KR | 1 |
| Pedapati, EV | 1 |
| Erickson, CA | 1 |
| Joshi, R | 1 |
| Marvin, W | 1 |
| Brown, JJ | 1 |
| Gray, JM | 1 |
| Roback, MG | 1 |
| Sethuraman, U | 1 |
| Farooqi, A | 1 |
| Kannikeswaran, N | 1 |
| Keidan, I | 1 |
| Ben-Menachem, E | 1 |
| Tzadok, M | 1 |
| Ben-Zeev, B | 1 |
| Berkenstadt, H | 1 |
| Fluegge, K | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Use of Dexmedetomidine for Procedural Sedation During EEG in Children Affected by Behavioural Disorders[NCT03799783] | Phase 2 | 19 participants (Actual) | Interventional | 2018-03-01 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
the PSSS is a validated scale for assessing the level of procedural sedation. It is a 6 items scale , from 0 to 5, where 5 is an alert patient and 0 is a deep sedation with abnormal vital signs. We evaluate patients 10 minutes after the infusion of dexmedetomidine. (NCT03799783)
Timeframe: 10 minutes
| Intervention | Participants (Count of Participants) |
|---|---|
| Dexmedetomidine | 13 |
any adverse event potentially related with DEX-administration (NCT03799783)
Timeframe: during and immediately after DEX infusion, up to 150 minutes after DEX infusion (time to first awakening)
| Intervention | Participants (Count of Participants) |
|---|---|
| Dexmedetomidine | 10 |
1 trial available for ketamine and Autism Spectrum Disorder
| Article | Year |
|---|---|
Brief Report: Intranasal Ketamine in Adolescents and Young Adults with Autism Spectrum Disorder-Initial Results of a Randomized, Controlled, Crossover, Pilot Study.
Topics: Administration, Intranasal; Adolescent; Adult; Autism Spectrum Disorder; Cross-Over Studies; Double- | 2021 |
7 other studies available for ketamine and Autism Spectrum Disorder
| Article | Year |
|---|---|
[Ketamine self-medication in a patient with autism spectrum disorder and comorbid treatment-resistant depression].
Topics: Autism Spectrum Disorder; Depression; Depressive Disorder, Major; Depressive Disorder, Treatment-Res | 2021 |
Autistic-like social deficits in hippocampal MeCP2 knockdown rat models are rescued by ketamine.
Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Disease Models, Animal; Hippocampus; Ketamine; | 2022 |
Ketamine administration in early postnatal life as a tool for mimicking Autism Spectrum Disorders core symptoms.
Topics: Animals; Autism Spectrum Disorder; Brain-Derived Neurotrophic Factor; Disease Models, Animal; gamma- | 2022 |
Apnea with ketamine sedation in a patient with severe anorexia nervosa: A case report.
Topics: Adolescent; Anesthesia; Anesthetics, Dissociative; Anorexia Nervosa; Apnea; Autism Spectrum Disorder | 2022 |
Procedural sedation in children with autism spectrum disorders in the emergency department.
Topics: Administration, Intranasal; Administration, Intravenous; Adolescent; Autism Spectrum Disorder; Child | 2019 |
Electroencephalography for children with autistic spectrum disorder: a sedation protocol.
Topics: Analgesics; Anesthesia; Autism Spectrum Disorder; Child; Child, Preschool; Chloral Hydrate; Dexmedet | 2015 |
Does the Clinical Benefit of Ketamine Treatment Offer Any Clues to Autism Spectrum Disorder Etiology?
Topics: Autism Spectrum Disorder; Child Development Disorders, Pervasive; Humans; Ketamine | 2016 |