ketamine has been researched along with Critical Illness in 45 studies
Ketamine: A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.
ketamine : A member of the class of cyclohexanones in which one of the hydrogens at position 2 is substituted by a 2-chlorophenyl group, while the other is substituted by a methylamino group.
Critical Illness: A disease or state in which death is possible or imminent.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A higher-than-usual resistance to standard sedation regimens in COVID-19 patients suffering from acute respiratory distress syndrome (ARDS) has led to the frequent use of the second-line anaesthetic agent ketamine." | 8.12 | Long-term ketamine infusion-induced cholestatic liver injury in COVID-19-associated acute respiratory distress syndrome. ( Andermatt, R; Bartussek, J; Buehler, PK; Camen, G; David, S; Erlebach, R; Hofmaenner, DA; Jüngst, C; Müllhaupt, B; Schuepbach, RA; Wendel-Garcia, PD, 2022) |
| "Ketamine was associated with a lower incidence of clinical hypotension within the 24 hour period following endotracheal intubation in septic patients." | 7.85 | Increased incidence of clinical hypotension with etomidate compared to ketamine for intubation in septic patients: A propensity matched analysis. ( Ali, NA; Cape, KM; Doepker, BA; Exline, MC; Phillips, G; Ryder, LP; Van Berkel, MA, 2017) |
| "We report a case series on the observed effects of low-dose ketamine infusions in 4 critically ill patients with varying complications related to prolonged critical illness." | 7.83 | Low-Dose Ketamine in Chronic Critical Illness. ( Darrah, D; Moitra, A; Moitra, VK; Patel, MK; Wunsch, H, 2016) |
| "There were no significant differences in maximum SOFA score or post-intubation hypotension between critically ill adults receiving ketamine vs." | 5.69 | The Effect of Ketamine Versus Etomidate for Rapid Sequence Intubation on Maximum Sequential Organ Failure Assessment Score: A Randomized Clinical Trial. ( Atkins, AH; Driver, BE; Klein, LR; Knack, SKS; Miner, JR; Moore, JC; Prekker, ME, 2023) |
| " The use of etomidate as the sedative agent in this context has been challenged because it might cause a reversible adrenal insufficiency, potentially associated with increased in-hospital morbidity." | 5.14 | Etomidate versus ketamine for rapid sequence intubation in acutely ill patients: a multicentre randomised controlled trial. ( Adnet, F; Albizzati, S; Anguel, N; Beltramini, A; Bertrand, L; Bollaert, PE; Brun-Buisson, C; Chollet-Xemard, C; Combes, X; Dhaouadi, M; Gamand, P; Jabre, P; Lapostolle, F; Lebail, G; Lefrant, JY; Maxime, V; Megarbane, B; Perdrizet, D; Ricard, JD; Ricard-Hibon, A; Vicaut, E; Vivien, B, 2009) |
| "Multimodal therapy encompasses a wide range of procedures and medications, including regional analgesia with continuous epidural or peripheral nerve block infusions, judicious opioids, acetaminophen, anti-inflammatory agents, anticonvulsants, ketamine, clonidine, mexiletine, antidepressants, and anxiolytics as options to treat or modulate pain at various sites of action." | 4.84 | The evolution of pain management in the critically ill trauma patient: Emerging concepts from the global war on terrorism. ( Black, IH; Malchow, RJ, 2008) |
| "A higher-than-usual resistance to standard sedation regimens in COVID-19 patients suffering from acute respiratory distress syndrome (ARDS) has led to the frequent use of the second-line anaesthetic agent ketamine." | 4.12 | Long-term ketamine infusion-induced cholestatic liver injury in COVID-19-associated acute respiratory distress syndrome. ( Andermatt, R; Bartussek, J; Buehler, PK; Camen, G; David, S; Erlebach, R; Hofmaenner, DA; Jüngst, C; Müllhaupt, B; Schuepbach, RA; Wendel-Garcia, PD, 2022) |
| "Ketamine was associated with a lower incidence of clinical hypotension within the 24 hour period following endotracheal intubation in septic patients." | 3.85 | Increased incidence of clinical hypotension with etomidate compared to ketamine for intubation in septic patients: A propensity matched analysis. ( Ali, NA; Cape, KM; Doepker, BA; Exline, MC; Phillips, G; Ryder, LP; Van Berkel, MA, 2017) |
| "We report a case series on the observed effects of low-dose ketamine infusions in 4 critically ill patients with varying complications related to prolonged critical illness." | 3.83 | Low-Dose Ketamine in Chronic Critical Illness. ( Darrah, D; Moitra, A; Moitra, VK; Patel, MK; Wunsch, H, 2016) |
| "In this large, pediatric multicenter registry, fentanyl, midazolam, and ketamine were the most commonly used induction agents, and the majority of tracheal intubations involved neuromuscular blockade." | 3.81 | Current medication practice and tracheal intubation safety outcomes from a prospective multicenter observational cohort study. ( Brown, CA; Howell, JD; Hsing, DD; Montgomery, V; Nadkarni, VM; Nishisaki, A; Parker, MM; Tarquinio, KM; Turner, DA; Walls, RM, 2015) |
| "Ketamine has favorable characteristics, making it an especially viable alternative for patients with respiratory and hemodynamic instability." | 2.94 | Adjunct low-dose ketamine infusion vs standard of care in mechanically ventilated critically ill patients at a Tertiary Saudi Hospital (ATTAINMENT Trial): study protocol for a randomized, prospective, pilot, feasibility trial. ( Alshaikh, K; Amer, M; Amin, R; Bawazeer, M; De Vol, E; Hijazi, M; Maghrabi, K; Rizwan, M; Shaban, M, 2020) |
| "Periintubation hypotension is associated with poor outcomes in the critically ill." | 2.90 | Ketamine/propofol admixture vs etomidate for intubation in the critically ill: KEEP PACE Randomized clinical trial. ( Bauer, PR; Brown, DR; Gajic, O; Gallo De Moraes, A; Hoskote, SS; Iyer, VN; Nicholson, WT; Oeckler, RA; Pickering, B; Schroeder, DR; Smischney, NJ, 2019) |
| " Findings may guide clinicians in consideration and dosing of ketamine for multimodal analgosedation." | 2.82 | Impact of Ketamine on Analgosedative Consumption in Critically Ill Patients: A Systematic Review and Meta-Analysis. ( Burry, LD; Chan, K; De Castro, C; Tse, C; Williamson, DR; Wunsch, H, 2022) |
| "Ketamine was not associated with mortality, on-target sedation, vasopressor dependence, or hospital length of stay." | 2.66 | Ketamine sedation in mechanically ventilated patients: A systematic review and meta-analysis. ( Fuller, BM; Manasco, AT; Roberts, BW; Stephens, RJ; Yaeger, LH, 2020) |
| "Ketamine has suggested potential benefit in several disease states impacting critically ill patients including pain, alcohol withdrawal syndrome, status epilepticus, and acute agitation." | 2.66 | The Reemergence of Ketamine for Treatment in Critically Ill Adults. ( Hurth, KP; Jaworski, A; Kirsch, WB; Rudoni, MA; Thomas, KB; Wohlfarth, KM, 2020) |
| " Dosing recommendations however are often based on strategies used in patients with normal body habitus." | 2.66 | Drug dosing in the critically ill obese patient-a focus on sedation, analgesia, and delirium. ( Barletta, JF; Erstad, BL, 2020) |
| " The CIN dosing range was 0." | 2.53 | Ketamine Continuous Infusions in Critically Ill Infants and Children. ( Gessouroun, MR; Golding, CL; Johnson, PN; Miller, JL, 2016) |
| "Ketamine has a unique pharmacological profile compared with more traditional agents such as opioids, which makes it an appealing alternative agent for analgosedation in the intensive care unit setting." | 2.53 | Ketamine for analgosedation in critically ill patients. ( Erstad, BL; Patanwala, AE, 2016) |
| " Etomidate and propofol, useful for short-term procedures, probably should be avoided for long-term use in the agitated patient because of potentially serious side effects." | 2.39 | Pharmacology of intravenous sedatives and opioids in critically ill patients. ( Levine, RL, 1994) |
| "Ketamine is an N-methyl-D-aspartate receptor antagonist with sedative, analgesic, and potentially neuroprotective properties." | 1.62 | Ketamine for critically ill patients with severe acute brain injury: Protocol for a systematic review with meta-analysis and Trial Sequential Analysis of randomised clinical trials. ( Andreasen, TH; Gluud, C; Lindschou, J; Madsen, FA; Møller, K, 2021) |
| "Ketamine has been considered the drug of choice for induction in these patients, but limited data exist." | 1.56 | Ketamine Use for Tracheal Intubation in Critically Ill Children Is Associated With a Lower Occurrence of Adverse Hemodynamic Events. ( Adu-Darko, M; Al-Subu, AM; Balkandier, S; Branca, A; Breuer, R; Bysani, GK; Conway, JA; Edwards, LR; Emeriaud, G; Esperanza, MC; Furlong-Dillard, J; Giuliano, JS; Harwayne-Gidansky, I; Howell, JD; Ikeyama, T; Jung, P; Kasagi, M; Kharayat, P; Kian Boon, JL; Kirby, A; Krawiec, C; Lee, A; McCarthy, MA; Meyer, K; Nadkarni, VM; Nett, S; Nishisaki, A; Nuthall, G; Orioles, A; Page-Goertz, C; Parsons, SJ; Pinto, M; Polikoff, L; Rehder, KJ; Sanders, RC; Shenoi, A; Shetty, R; Shlomovich, M; Shults, J; Skippen, P; Tallent, S; Tarquinio, KM; Thyagarajan, S; Toedt-Pingel, I; Turner, DA; Vanderford, P; Weiss, SL; Zeqo, J, 2020) |
| " Exploratory evaluation of independent factors associated with ketamine responders (50% or more relative reduction in analgesic-sedative dosing requirements at 24 hrs) and nonresponders (less than 50% relative reduction) was performed using multivariate logistic regression." | 1.51 | Continuous Infusion Ketamine for Adjunctive Analgosedation in Mechanically Ventilated, Critically Ill Patients. ( Carter, KE; Droege, CA; Garber, PM; Harger, NJ; Mueller, EW, 2019) |
| "Ketamine was utilized in 61% of patients after other medications were ineffective." | 1.51 | Prehospital Use of Ketamine: Effectiveness in Critically Ill and Injured Patients. ( Berns, K; Jenkins, D; Zietlow, J; Zietlow, S, 2019) |
| "To describe the dosing and safety considerations of ketamine for adjunct sedation in a population of mechanically ventilated critically ill patients targeting light sedation." | 1.48 | Ketamine Infusion for Adjunct Sedation in Mechanically Ventilated Adults. ( Bahr, M; Bain, W; Barbash, I; Chin, K; Groetzinger, LM; McVerry, BJ; Rivosecchi, RM, 2018) |
| " Secondary objectives were to identify the patient population in which ketamine was initiated, assess the proportion of time patients were at their goal level of sedation, and determine the dosing patterns of adjunctive sedative agents." | 1.46 | Impact of Ketamine Use on Adjunctive Analgesic and Sedative Medications in Critically Ill Trauma Patients. ( Chui, SJ; Harbourt, K; Pajoumand, M; Pruskowski, KA; Reynolds, HN, 2017) |
| "Ketamine was used most often in men (52 (73%)), and the median age was 49 years (IQR: 31, 69)." | 1.37 | A prospective review of the use of ketamine to facilitate endotracheal intubation in the helicopter emergency medical services (HEMS) setting. ( Anstett, D; Bawden, J; Mackenzie, M; Rowe, BH; Sibley, A; Villa-Roel, C, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (6.67) | 18.2507 |
| 2000's | 5 (11.11) | 29.6817 |
| 2010's | 23 (51.11) | 24.3611 |
| 2020's | 14 (31.11) | 2.80 |
| Authors | Studies |
|---|---|
| Madsen, FA | 1 |
| Andreasen, TH | 1 |
| Lindschou, J | 1 |
| Gluud, C | 1 |
| Møller, K | 1 |
| Matchett, G | 1 |
| Gasanova, I | 1 |
| Riccio, CA | 1 |
| Nasir, D | 1 |
| Sunna, MC | 1 |
| Bravenec, BJ | 1 |
| Azizad, O | 1 |
| Farrell, B | 1 |
| Minhajuddin, A | 1 |
| Stewart, JW | 1 |
| Liang, LW | 1 |
| Moon, TS | 1 |
| Fox, PE | 1 |
| Ebeling, CG | 1 |
| Smith, MN | 1 |
| Trousdale, D | 1 |
| Ogunnaike, BO | 1 |
| Chan, K | 1 |
| Burry, LD | 1 |
| Tse, C | 1 |
| Wunsch, H | 3 |
| De Castro, C | 1 |
| Williamson, DR | 1 |
| Barthélémy, R | 1 |
| Beaucoté, V | 1 |
| Gayat, E | 1 |
| Mebazaa, A | 1 |
| Chousterman, BG | 1 |
| Gershengorn, HB | 1 |
| Elhamamsy, MM | 1 |
| Aldemerdash, AM | 1 |
| Zahran, FB | 1 |
| Ezz, GFM | 1 |
| AlSaud, SA | 1 |
| Boules, ML | 1 |
| Abdelhady, MA | 1 |
| Hamed, MA | 1 |
| Wendel-Garcia, PD | 1 |
| Erlebach, R | 1 |
| Hofmaenner, DA | 1 |
| Camen, G | 1 |
| Schuepbach, RA | 1 |
| Jüngst, C | 1 |
| Müllhaupt, B | 1 |
| Bartussek, J | 1 |
| Buehler, PK | 1 |
| Andermatt, R | 1 |
| David, S | 1 |
| Eimer, C | 1 |
| Reifferscheid, F | 1 |
| Jung, P | 2 |
| Rudolph, M | 1 |
| Terboven, T | 1 |
| Hoffmann, F | 1 |
| Lorenzen, U | 1 |
| Köser, A | 1 |
| Seewald, S | 1 |
| Knack, SKS | 1 |
| Prekker, ME | 1 |
| Moore, JC | 1 |
| Klein, LR | 1 |
| Atkins, AH | 1 |
| Miner, JR | 1 |
| Driver, BE | 1 |
| Park, S | 1 |
| Choi, AY | 1 |
| Park, E | 1 |
| Park, HJ | 1 |
| Lee, J | 1 |
| Lee, H | 1 |
| Kim, J | 1 |
| Cho, J | 1 |
| Manasco, AT | 1 |
| Stephens, RJ | 1 |
| Yaeger, LH | 1 |
| Roberts, BW | 1 |
| Fuller, BM | 1 |
| Bawazeer, M | 1 |
| Amer, M | 1 |
| Maghrabi, K | 1 |
| Alshaikh, K | 1 |
| Amin, R | 1 |
| Rizwan, M | 1 |
| Shaban, M | 1 |
| De Vol, E | 1 |
| Hijazi, M | 1 |
| Hurth, KP | 1 |
| Jaworski, A | 1 |
| Thomas, KB | 1 |
| Kirsch, WB | 1 |
| Rudoni, MA | 1 |
| Wohlfarth, KM | 1 |
| Conway, JA | 1 |
| Kharayat, P | 1 |
| Sanders, RC | 1 |
| Nett, S | 1 |
| Weiss, SL | 1 |
| Edwards, LR | 1 |
| Breuer, R | 1 |
| Kirby, A | 1 |
| Krawiec, C | 1 |
| Page-Goertz, C | 1 |
| Polikoff, L | 1 |
| Turner, DA | 2 |
| Shults, J | 1 |
| Giuliano, JS | 1 |
| Orioles, A | 1 |
| Balkandier, S | 1 |
| Emeriaud, G | 1 |
| Rehder, KJ | 1 |
| Kian Boon, JL | 1 |
| Shenoi, A | 1 |
| Vanderford, P | 1 |
| Nuthall, G | 1 |
| Lee, A | 1 |
| Zeqo, J | 1 |
| Parsons, SJ | 1 |
| Furlong-Dillard, J | 1 |
| Meyer, K | 1 |
| Harwayne-Gidansky, I | 1 |
| Adu-Darko, M | 1 |
| Bysani, GK | 1 |
| McCarthy, MA | 1 |
| Shlomovich, M | 1 |
| Toedt-Pingel, I | 1 |
| Branca, A | 1 |
| Esperanza, MC | 1 |
| Al-Subu, AM | 1 |
| Pinto, M | 1 |
| Tallent, S | 1 |
| Shetty, R | 1 |
| Thyagarajan, S | 1 |
| Ikeyama, T | 1 |
| Tarquinio, KM | 2 |
| Skippen, P | 1 |
| Kasagi, M | 1 |
| Howell, JD | 2 |
| Nadkarni, VM | 2 |
| Nishisaki, A | 2 |
| Erstad, BL | 3 |
| Barletta, JF | 1 |
| Pruskowski, KA | 1 |
| Harbourt, K | 1 |
| Pajoumand, M | 1 |
| Chui, SJ | 1 |
| Reynolds, HN | 1 |
| Groetzinger, LM | 1 |
| Rivosecchi, RM | 1 |
| Bain, W | 1 |
| Bahr, M | 1 |
| Chin, K | 1 |
| McVerry, BJ | 1 |
| Barbash, I | 1 |
| Garber, PM | 1 |
| Droege, CA | 1 |
| Carter, KE | 1 |
| Harger, NJ | 1 |
| Mueller, EW | 1 |
| Wampole, CR | 1 |
| Smith, KE | 1 |
| Zietlow, J | 1 |
| Berns, K | 1 |
| Jenkins, D | 1 |
| Zietlow, S | 1 |
| Clayton, AR | 1 |
| Smischney, NJ | 3 |
| Nicholson, WT | 1 |
| Brown, DR | 1 |
| Gallo De Moraes, A | 3 |
| Hoskote, SS | 3 |
| Pickering, B | 1 |
| Oeckler, RA | 1 |
| Iyer, VN | 1 |
| Gajic, O | 1 |
| Schroeder, DR | 1 |
| Bauer, PR | 1 |
| Montgomery, V | 1 |
| Hsing, DD | 1 |
| Parker, MM | 1 |
| Brown, CA | 1 |
| Walls, RM | 1 |
| Racedo Africano, CJ | 2 |
| Reddy, DR | 2 |
| Tedja, R | 2 |
| Thakur, L | 2 |
| Pannu, JK | 2 |
| Hassebroek, EC | 2 |
| Kudchadkar, SR | 1 |
| Shaffner, DH | 1 |
| Carrera, PM | 1 |
| Hinds, RF | 1 |
| Moitra, VK | 1 |
| Patel, MK | 1 |
| Darrah, D | 1 |
| Moitra, A | 1 |
| Patanwala, AE | 2 |
| Martin, JR | 1 |
| Mcqueen, C | 1 |
| Miescier, MJ | 1 |
| Bryant, RJ | 1 |
| Nelson, DS | 1 |
| Golding, CL | 1 |
| Miller, JL | 1 |
| Gessouroun, MR | 1 |
| Johnson, PN | 1 |
| Oddo, M | 1 |
| Crippa, IA | 1 |
| Mehta, S | 1 |
| Menon, D | 1 |
| Payen, JF | 1 |
| Taccone, FS | 1 |
| Citerio, G | 1 |
| Mora, AG | 1 |
| Ganem, VJ | 1 |
| Ervin, AT | 1 |
| Maddry, JK | 1 |
| Bebarta, VS | 1 |
| Chen, JT | 1 |
| Lin, YL | 1 |
| Chen, TL | 1 |
| Tai, YT | 1 |
| Chen, CY | 1 |
| Chen, RM | 1 |
| Van Berkel, MA | 1 |
| Exline, MC | 1 |
| Cape, KM | 1 |
| Ryder, LP | 1 |
| Phillips, G | 1 |
| Ali, NA | 1 |
| Doepker, BA | 1 |
| Malchow, RJ | 1 |
| Black, IH | 1 |
| Rapeport, DA | 1 |
| Martyr, JW | 1 |
| Wang, LP | 1 |
| Jabre, P | 1 |
| Combes, X | 1 |
| Lapostolle, F | 1 |
| Dhaouadi, M | 1 |
| Ricard-Hibon, A | 1 |
| Vivien, B | 1 |
| Bertrand, L | 1 |
| Beltramini, A | 1 |
| Gamand, P | 1 |
| Albizzati, S | 1 |
| Perdrizet, D | 1 |
| Lebail, G | 1 |
| Chollet-Xemard, C | 1 |
| Maxime, V | 1 |
| Brun-Buisson, C | 1 |
| Lefrant, JY | 1 |
| Bollaert, PE | 1 |
| Megarbane, B | 1 |
| Ricard, JD | 1 |
| Anguel, N | 1 |
| Vicaut, E | 1 |
| Adnet, F | 1 |
| Sibley, A | 1 |
| Mackenzie, M | 1 |
| Bawden, J | 1 |
| Anstett, D | 1 |
| Villa-Roel, C | 1 |
| Rowe, BH | 1 |
| Bujok, G | 1 |
| Knapik, P | 1 |
| Macioł, Z | 1 |
| Levine, RL | 1 |
| Hirota, K | 1 |
| Lambert, DG | 1 |
| Heller, A | 1 |
| Heller, S | 1 |
| Blecken, S | 1 |
| Urbaschek, R | 1 |
| Koch, T | 1 |
| Golden, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Etomidate Versus Ketamine for Emergency Endotracheal Intubation: a Prospective Randomized Clinical Trial[NCT02643381] | Phase 4 | 801 participants (Actual) | Interventional | 2016-06-06 | Completed | ||
| Anesthesia for Upper Endoscopy and Colonoscopy in Cardiac Patients With Acute Anemia: Pretreatment With Low-dose Ketamine Can Reduce the Dose of Etomidate. A Randomized Clinical Trial.[NCT04857450] | 60 participants (Anticipated) | Interventional | 2020-11-20 | Recruiting | |||
| Adjunct Low Dose Ketamine Infusion Versus Standard of Care in Mechanically Ventilated Critically Ill Patients at a Tertiary Saudi Hospital: Randomized, Prospective, Pilot Trial[NCT04075006] | Phase 3 | 84 participants (Actual) | Interventional | 2019-08-28 | Completed | ||
| A Pilot Study of Ketamine Sedation Initiated Early After Aneurysmal Subarachnoid Hemorrhage: Effect on Vasospasm, Delayed Cerebral Ischemia, and Functional Outcomes[NCT05032118] | Phase 2/Phase 3 | 0 participants (Actual) | Interventional | 2023-04-27 | Withdrawn (stopped due to Institution change, no IRB approval) | ||
| "Ketamine / Propofol Admixture Ketofol at Induction in the Critically Ill Against Etomidate: KEEP PACE Trial"[NCT02105415] | Phase 2/Phase 3 | 160 participants (Actual) | Interventional | 2014-04-30 | Completed | ||
| Ketofol vs Dexmedetomidine for Preventing Post-operative Delirium in Elderly Patients Undergoing Intestinal Obstruction Surgeries. A Randomized Controlled Study[NCT04816162] | Phase 4 | 120 participants (Actual) | Interventional | 2021-03-25 | Completed | ||
| Efficacy and Safety of Continuous Infusion of Ketamine in Pediatric Intensive Care Unit (KISS Study)[NCT04427605] | 57 participants (Actual) | Observational | 2019-04-01 | Completed | |||
| Clinical Study of the Safety and Efficacy of Analgesia-first Minimal Sedation as an Early Antihypertensive Treatment for Spontaneous Intracerebral Hemorrhage[NCT03207100] | 338 participants (Actual) | Interventional | 2017-12-06 | Completed | |||
| Dexmedetomidine Versus Ketamine to Facilitate Non-invasive Ventilation After Blunt Chest Trauma[NCT05175781] | 45 participants (Actual) | Interventional | 2022-01-18 | Completed | |||
| Comparison of Ultrasound Guided Femoral Nerve Blockade and Standard Parenteral Opioid Pain Management Alone in Patients With Hip Fracture in the Emergency Department[NCT02381717] | 60 participants (Anticipated) | Interventional | 2015-08-31 | Recruiting | |||
| Managing Acute Pain in Critically Ill Non-communicative Palliative Care Patients[NCT02127086] | 377 participants (Actual) | Interventional | 2015-03-31 | Completed | |||
| Etomidate Versus Propofol As An Anesthesia Induction Agent For Patients Undergoing CABG Surgery, Assessing Hemodynamic Stability. A Single Blinded, Randomized Controlled Trial.[NCT06068764] | Phase 4 | 300 participants (Anticipated) | Interventional | 2023-12-05 | Recruiting | ||
| Ketamine Versus Etomidate During Rapid Sequence Intubation: Consequences on Hospital Morbidity[NCT00440102] | Phase 4 | 655 participants (Actual) | Interventional | 2007-04-30 | Completed | ||
| The Prevention of Post Operative Cognitive Dysfunction by Ketamine: a Prospective Multicenter Randomized Blinded Placebo-controlled Trial in Elderly Patients Undergoing Elective Orthopaedic Surgery[NCT02892916] | Phase 3 | 307 participants (Actual) | Interventional | 2017-03-20 | Completed | ||
| Prospective Study of Induction Medications Used in the Rapid Sequence Intubation of Trauma Patients and a Comparison of Effects on Outcomes[NCT04291521] | 7,000 participants (Anticipated) | Observational | 2024-01-01 | Not yet recruiting | |||
| Ketamine Frequency Treatment for Major Depressive Disorder[NCT00646087] | Phase 4 | 0 participants (Actual) | Interventional | 2008-03-31 | Withdrawn (stopped due to Pilot study determined that this study would not be feasible.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Time (in days) from start to end of catecholamine therapy (NCT02643381)
Timeframe: From time of documented start of therapy until the time of documented end of therapy, assessed up to 28 days
| Intervention | Days (Median) |
|---|---|
| Etomidate | 1 |
| Ketamine | 1 |
Duration (in days) from insertion to removal of mechanical ventilation (NCT02643381)
Timeframe: From time of documented insertion until the time of documented removal, assessed up to 28 days
| Intervention | Days (Median) |
|---|---|
| Etomidate | 5 |
| Ketamine | 5 |
Length (in days) of ICU stay (NCT02643381)
Timeframe: Assessed up to 28 days
| Intervention | Days (Median) |
|---|---|
| Etomidate | 8 |
| Ketamine | 9 |
New diagnosis of adrenal insufficiency will be assessed by the the primary treating medical or surgical team via chart review (NCT02643381)
Timeframe: Day 28
| Intervention | Participants (Count of Participants) |
|---|---|
| Etomidate | 11 |
| Ketamine | 4 |
Survival is defined as the number of participants survived at day 28 following emergency endotracheal intubation (NCT02643381)
Timeframe: Day 28
| Intervention | Participants (Count of Participants) |
|---|---|
| Etomidate | 254 |
| Ketamine | 264 |
Survival is defined as the number of participants survived at day 7 following emergency endotracheal intubation (NCT02643381)
Timeframe: Day 7
| Intervention | Participants (Count of Participants) |
|---|---|
| Etomidate | 306 |
| Ketamine | 336 |
Sequential Organ Failure Assessment (SOFA) is a scoring system that assesses the performance of several organ systems. Possible scores range from 0 to 24. Higher score indicates higher degree of organ dysfunction (NCT02643381)
Timeframe: Day 1, Day 2, Day 3, Day 4
| Intervention | score on a scale (Mean) | |||
|---|---|---|---|---|
| Day 1 | Day 2 | Day 3 | Day 4 | |
| Etomidate | 10.7 | 9.8 | 8.4 | 7.4 |
| Ketamine | 10.9 | 9.5 | 8.4 | 7.4 |
comparison of intensive care unit free days between the two groups (NCT02105415)
Timeframe: hospital discharge or day 28, whichever comes first
| Intervention | days (Median) |
|---|---|
| Etomidate | 16 |
| Ketamine / Propofol Admixture | 17 |
comparison of mechanical ventilation free days between the two groups (NCT02105415)
Timeframe: hospital discharge or day 28, whichever comes first
| Intervention | days (Median) |
|---|---|
| Etomidate | 22 |
| Ketamine / Propofol Admixture | 20 |
In-hospital/28 day mortality among patients in ketamine/propofol combination compared to in-hospital/28-day mortality in etomidate. (NCT02105415)
Timeframe: Hospital Discharge or Day 28, whichever comes first
| Intervention | Participants (Count of Participants) |
|---|---|
| Etomidate | 26 |
| Ketamine / Propofol Admixture | 25 |
Comparison of number of participants who were positive for delirium using CAM-ICU between groups (NCT02105415)
Timeframe: up to 24 hours post study drug administration
| Intervention | Participants (Count of Participants) |
|---|---|
| Etomidate | 7 |
| Ketamine / Propofol Admixture | 4 |
Incidence of adrenal insufficiency between ketamine/propofol admixture and etomidate. Adrenal insuffiency was evaluated with co-syntropin stimulation test. (NCT02105415)
Timeframe: up to 24 hours post study drug administration
| Intervention | Participants (Count of Participants) |
|---|---|
| Etomidate (3-5 Hours) | 13 |
| Ketamine/Propofol Admixture (3-5 Hours) | 5 |
| Etomidate (23-25 Hours) | 9 |
| Ketamine/Propofol Admixture (23-25 Hours) | 6 |
blood product transfusions [Red Blood Cells vs. non-Red Blood Cells] between the two groups (NCT02105415)
Timeframe: hospital discharge or day 28, whichever comes first
| Intervention | Participants (Count of Participants) | ||
|---|---|---|---|
| Red blood cell | Non-red blood cell | Colloid | |
| Etomidate | 21 | 16 | 28 |
| Ketamine / Propofol Admixture | 13 | 8 | 26 |
Mean arterial pressure for the ketamine/propofol group at a 1:1 dose ratio compared to the etomidate group within the first 15 minutes post-administration in patients in need of urgent and/or emergent endotracheal intubation, as defined by any intubation within the intensive care unit excluding intubations for elective procedural events and codes. (NCT02105415)
Timeframe: baseline and every 5 minutes up to 15 minutes minutes post study drug administration
| Intervention | mm Hg (Mean) | |||
|---|---|---|---|---|
| Baseline | 5 minutes | 10 minutes | 15 minutes | |
| Etomidate | 82.8 | 81.7 | 81.9 | 79.1 |
| Ketamine / Propofol Admixture | 80.9 | 77.6 | 75.3 | 75.5 |
The use of vasoactive medications to restore the blood pressure post-administration in the ketamine/propofol combination as compared to the etomidate group. (NCT02105415)
Timeframe: up to 24 hours post study drug administration
| Intervention | Participants (Count of Participants) | ||
|---|---|---|---|
| Pre-treament | New-onset pressors (within 3 minutes) | Delayed-onset pressors (within 24 hours) | |
| Etomidate | 1 | 12 | 57 |
| Ketamine / Propofol Admixture | 5 | 18 | 64 |
11 reviews available for ketamine and Critical Illness
| Article | Year |
|---|---|
Impact of Ketamine on Analgosedative Consumption in Critically Ill Patients: A Systematic Review and Meta-Analysis.
Topics: Analgesics, Opioid; Critical Illness; Humans; Hypnotics and Sedatives; Intensive Care Units; Ketamin | 2022 |
Ketamine sedation in mechanically ventilated patients: A systematic review and meta-analysis.
Topics: Anesthesia; Critical Illness; Fentanyl; Humans; Hypnotics and Sedatives; Ketamine; Midazolam; Observ | 2020 |
The Reemergence of Ketamine for Treatment in Critically Ill Adults.
Topics: Critical Illness; Dose-Response Relationship, Drug; Drug Administration Routes; Humans; Hypnotics an | 2020 |
Drug dosing in the critically ill obese patient-a focus on sedation, analgesia, and delirium.
Topics: Analgesia; Analgesics, Non-Narcotic; Analgesics, Opioid; Benzodiazepines; Critical Illness; Deep Sed | 2020 |
My Struggle To Access Lifesaving Mental Health Care.
Topics: Adult; Critical Illness; Depressive Disorder; Female; Health Services Accessibility; Humans; Ketamin | 2019 |
Ketamine for Analgosedation in the Intensive Care Unit: A Systematic Review.
Topics: Analgesics; Critical Care; Critical Illness; Humans; Infusions, Intravenous; Intensive Care Units; K | 2017 |
Ketamine Continuous Infusions in Critically Ill Infants and Children.
Topics: Analgesics; Child; Critical Illness; Humans; Hypnotics and Sedatives; Infant; Ketamine; Substance Wi | 2016 |
Optimizing sedation in patients with acute brain injury.
Topics: Analgesia; Brain Injuries; Critical Care; Critical Illness; Deep Sedation; Humans; Hypnotics and Sed | 2016 |
Ketamine for analgosedation in critically ill patients.
Topics: Analgesics; Conscious Sedation; Critical Illness; Humans; Hypnotics and Sedatives; Intensive Care Un | 2016 |
The evolution of pain management in the critically ill trauma patient: Emerging concepts from the global war on terrorism.
Topics: Analgesia; Analgesics; Analgesics, Opioid; Anesthesia, Conduction; Anti-Inflammatory Agents, Non-Ste | 2008 |
The evolution of pain management in the critically ill trauma patient: Emerging concepts from the global war on terrorism.
Topics: Analgesia; Analgesics; Analgesics, Opioid; Anesthesia, Conduction; Anti-Inflammatory Agents, Non-Ste | 2008 |
The evolution of pain management in the critically ill trauma patient: Emerging concepts from the global war on terrorism.
Topics: Analgesia; Analgesics; Analgesics, Opioid; Anesthesia, Conduction; Anti-Inflammatory Agents, Non-Ste | 2008 |
The evolution of pain management in the critically ill trauma patient: Emerging concepts from the global war on terrorism.
Topics: Analgesia; Analgesics; Analgesics, Opioid; Anesthesia, Conduction; Anti-Inflammatory Agents, Non-Ste | 2008 |
Pharmacology of intravenous sedatives and opioids in critically ill patients.
Topics: Analgesics, Opioid; Antipsychotic Agents; Barbiturates; Benzodiazepines; Cardiovascular System; Crit | 1994 |
7 trials available for ketamine and Critical Illness
| Article | Year |
|---|---|
Etomidate versus ketamine for emergency endotracheal intubation: a randomized clinical trial.
Topics: Critical Illness; Etomidate; Humans; Intubation, Intratracheal; Ketamine; Prospective Studies | 2022 |
Effects of adding low-dose ketamine to etomidate on serum cortisol levels in critically ill cardiac patients: a randomized clinical trial.
Topics: Adult; Anesthetics, Intravenous; Critical Illness; Etomidate; Humans; Hydrocortisone; Ketamine | 2022 |
The Effect of Ketamine Versus Etomidate for Rapid Sequence Intubation on Maximum Sequential Organ Failure Assessment Score: A Randomized Clinical Trial.
Topics: Adult; Anesthetics, Intravenous; Critical Illness; Etomidate; Humans; Hypotension; Intubation, Intra | 2023 |
Adjunct low-dose ketamine infusion vs standard of care in mechanically ventilated critically ill patients at a Tertiary Saudi Hospital (ATTAINMENT Trial): study protocol for a randomized, prospective, pilot, feasibility trial.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Critical Care; Critical Illness; Feasibility Studies; Fe | 2020 |
Ketamine/propofol admixture vs etomidate for intubation in the critically ill: KEEP PACE Randomized clinical trial.
Topics: Adult; Anesthetics, Intravenous; Critical Illness; Dose-Response Relationship, Drug; Drug Monitoring | 2019 |
Ketamine/propofol admixture (ketofol) at induction in the critically ill against etomidate (KEEP PACE trial): study protocol for a randomized controlled trial.
Topics: Adrenal Glands; Anesthetics, Combined; Anesthetics, Dissociative; Anesthetics, Intravenous; Clinical | 2015 |
Ketamine/propofol admixture (ketofol) at induction in the critically ill against etomidate (KEEP PACE trial): study protocol for a randomized controlled trial.
Topics: Adrenal Glands; Anesthetics, Combined; Anesthetics, Dissociative; Anesthetics, Intravenous; Clinical | 2015 |
Ketamine/propofol admixture (ketofol) at induction in the critically ill against etomidate (KEEP PACE trial): study protocol for a randomized controlled trial.
Topics: Adrenal Glands; Anesthetics, Combined; Anesthetics, Dissociative; Anesthetics, Intravenous; Clinical | 2015 |
Ketamine/propofol admixture (ketofol) at induction in the critically ill against etomidate (KEEP PACE trial): study protocol for a randomized controlled trial.
Topics: Adrenal Glands; Anesthetics, Combined; Anesthetics, Dissociative; Anesthetics, Intravenous; Clinical | 2015 |
Etomidate versus ketamine for rapid sequence intubation in acutely ill patients: a multicentre randomised controlled trial.
Topics: Adrenal Insufficiency; Aged; Anesthetics, Intravenous; Critical Illness; Etomidate; Female; France; | 2009 |
Etomidate versus ketamine for rapid sequence intubation in acutely ill patients: a multicentre randomised controlled trial.
Topics: Adrenal Insufficiency; Aged; Anesthetics, Intravenous; Critical Illness; Etomidate; Female; France; | 2009 |
Etomidate versus ketamine for rapid sequence intubation in acutely ill patients: a multicentre randomised controlled trial.
Topics: Adrenal Insufficiency; Aged; Anesthetics, Intravenous; Critical Illness; Etomidate; Female; France; | 2009 |
Etomidate versus ketamine for rapid sequence intubation in acutely ill patients: a multicentre randomised controlled trial.
Topics: Adrenal Insufficiency; Aged; Anesthetics, Intravenous; Critical Illness; Etomidate; Female; France; | 2009 |
Etomidate versus ketamine for rapid sequence intubation in acutely ill patients: a multicentre randomised controlled trial.
Topics: Adrenal Insufficiency; Aged; Anesthetics, Intravenous; Critical Illness; Etomidate; Female; France; | 2009 |
Etomidate versus ketamine for rapid sequence intubation in acutely ill patients: a multicentre randomised controlled trial.
Topics: Adrenal Insufficiency; Aged; Anesthetics, Intravenous; Critical Illness; Etomidate; Female; France; | 2009 |
Etomidate versus ketamine for rapid sequence intubation in acutely ill patients: a multicentre randomised controlled trial.
Topics: Adrenal Insufficiency; Aged; Anesthetics, Intravenous; Critical Illness; Etomidate; Female; France; | 2009 |
Etomidate versus ketamine for rapid sequence intubation in acutely ill patients: a multicentre randomised controlled trial.
Topics: Adrenal Insufficiency; Aged; Anesthetics, Intravenous; Critical Illness; Etomidate; Female; France; | 2009 |
Etomidate versus ketamine for rapid sequence intubation in acutely ill patients: a multicentre randomised controlled trial.
Topics: Adrenal Insufficiency; Aged; Anesthetics, Intravenous; Critical Illness; Etomidate; Female; France; | 2009 |
Etomidate versus ketamine for rapid sequence intubation in acutely ill patients: a multicentre randomised controlled trial.
Topics: Adrenal Insufficiency; Aged; Anesthetics, Intravenous; Critical Illness; Etomidate; Female; France; | 2009 |
Etomidate versus ketamine for rapid sequence intubation in acutely ill patients: a multicentre randomised controlled trial.
Topics: Adrenal Insufficiency; Aged; Anesthetics, Intravenous; Critical Illness; Etomidate; Female; France; | 2009 |
Etomidate versus ketamine for rapid sequence intubation in acutely ill patients: a multicentre randomised controlled trial.
Topics: Adrenal Insufficiency; Aged; Anesthetics, Intravenous; Critical Illness; Etomidate; Female; France; | 2009 |
Etomidate versus ketamine for rapid sequence intubation in acutely ill patients: a multicentre randomised controlled trial.
Topics: Adrenal Insufficiency; Aged; Anesthetics, Intravenous; Critical Illness; Etomidate; Female; France; | 2009 |
Etomidate versus ketamine for rapid sequence intubation in acutely ill patients: a multicentre randomised controlled trial.
Topics: Adrenal Insufficiency; Aged; Anesthetics, Intravenous; Critical Illness; Etomidate; Female; France; | 2009 |
Etomidate versus ketamine for rapid sequence intubation in acutely ill patients: a multicentre randomised controlled trial.
Topics: Adrenal Insufficiency; Aged; Anesthetics, Intravenous; Critical Illness; Etomidate; Female; France; | 2009 |
Etomidate versus ketamine for rapid sequence intubation in acutely ill patients: a multicentre randomised controlled trial.
Topics: Adrenal Insufficiency; Aged; Anesthetics, Intravenous; Critical Illness; Etomidate; Female; France; | 2009 |
27 other studies available for ketamine and Critical Illness
| Article | Year |
|---|---|
Ketamine for critically ill patients with severe acute brain injury: Protocol for a systematic review with meta-analysis and Trial Sequential Analysis of randomised clinical trials.
Topics: Brain Injuries; Critical Care; Critical Illness; Humans; Ketamine; Meta-Analysis as Topic; Quality o | 2021 |
Which dose of ketamine to use for rapid sequence intubation in critically ill patients in hemodynamic shock?
Topics: Critical Illness; Etomidate; Hemodynamics; Humans; Intubation, Intratracheal; Ketamine; Rapid Sequen | 2022 |
Temporal Trends and Variability in Ketamine Use for Mechanically Ventilated Adults in the United States.
Topics: Adult; Critical Illness; Humans; Hypnotics and Sedatives; Infusions, Intravenous; Intensive Care Uni | 2022 |
Long-term ketamine infusion-induced cholestatic liver injury in COVID-19-associated acute respiratory distress syndrome.
Topics: Bilirubin; COVID-19; Critical Illness; Humans; Hypnotics and Sedatives; Ketamine; Liver; Propofol; R | 2022 |
Pre-hospital analgesia in pediatric trauma and critically ill patients: An analysis of a German air rescue service.
Topics: Analgesia; Analgesics; Analgesics, Opioid; Child; Critical Illness; Emergency Medical Services; Fent | 2023 |
Effects of continuous ketamine infusion on hemodynamics and mortality in critically ill children.
Topics: Blood Pressure; Child, Preschool; Critical Illness; Female; Heart Diseases; Heart Rate; Hemodynamics | 2019 |
Ketamine Use for Tracheal Intubation in Critically Ill Children Is Associated With a Lower Occurrence of Adverse Hemodynamic Events.
Topics: Adolescent; Age Factors; Analgesics; Child; Child, Preschool; Critical Illness; Female; Hemodynamics | 2020 |
Impact of Ketamine Use on Adjunctive Analgesic and Sedative Medications in Critically Ill Trauma Patients.
Topics: Adult; Analgesics; Analgesics, Opioid; Critical Illness; Dexmedetomidine; Drug Utilization; Female; | 2017 |
Ketamine Infusion for Adjunct Sedation in Mechanically Ventilated Adults.
Topics: Adult; Analgesics; Cohort Studies; Critical Illness; Dose-Response Relationship, Drug; Drug Therapy, | 2018 |
Continuous Infusion Ketamine for Adjunctive Analgosedation in Mechanically Ventilated, Critically Ill Patients.
Topics: Adult; Analgesics; Critical Illness; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagon | 2019 |
Beyond Opioids for Pain Management in Adult Critically Ill Patients.
Topics: Acetaminophen; Adrenergic alpha-2 Receptor Agonists; Adult; Analgesia; Analgesics; Analgesics, Non-N | 2019 |
Prehospital Use of Ketamine: Effectiveness in Critically Ill and Injured Patients.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesics; Child; Child, Preschool; Critical Illness; E | 2019 |
Current medication practice and tracheal intubation safety outcomes from a prospective multicenter observational cohort study.
Topics: Adolescent; Child; Child, Preschool; Critical Illness; Female; Fentanyl; Hemodynamics; Humans; Hypno | 2015 |
Ketamine and propofol combination ("ketofol") for endotracheal intubations in critically ill patients: a case series.
Topics: Adult; Aged; Anesthetics, Dissociative; Anesthetics, Intravenous; Critical Illness; Drug Therapy, Co | 2015 |
Pharmacologic recipes for tracheal intubation in the PICU: what's on the menu?
Topics: Critical Illness; Female; Fentanyl; Humans; Intubation, Intratracheal; Ketamine; Male; Midazolam; Ne | 2015 |
Low-Dose Ketamine in Chronic Critical Illness.
Topics: Analgesics; Anxiety; Chronic Disease; Critical Care; Critical Illness; Dose-Response Relationship, D | 2016 |
Clinical interventions by helicopter emergency medical service teams: Time for key performance indicators?
Topics: Air Ambulances; Conscious Sedation; Critical Illness; Emergency Medical Services; Female; Humans; Ke | 2016 |
Delayed sequence intubation with ketamine in 2 critically ill children.
Topics: Adjuvants, Anesthesia; Anesthetics, Intravenous; Atropine; Child; Critical Illness; Dopamine; Dopami | 2016 |
En Route Use of Analgesics in Nonintubated, Critically Ill Patients Transported by U.S. Air Force Critical Care Air Transport Teams.
Topics: Adult; Aerospace Medicine; Afghan Campaign 2001-; Air Ambulances; Analgesics; Critical Care; Critica | 2016 |
Ketamine alleviates bradykinin-induced disruption of the mouse cerebrovascular endothelial cell-constructed tight junction barrier via a calcium-mediated redistribution of occludin polymerization.
Topics: Animals; Blood-Brain Barrier; Bradykinin; Calcium; Critical Illness; Endothelial Cells; Endothelium, | 2016 |
Increased incidence of clinical hypotension with etomidate compared to ketamine for intubation in septic patients: A propensity matched analysis.
Topics: Anesthetics, Intravenous; Cohort Studies; Critical Care; Critical Illness; Etomidate; Female; Humans | 2017 |
The use of "ketofol" (ketamine-propofol admixture) infusion in conjunction with regional anaesthesia.
Topics: Aged; Aged, 80 and over; Anesthesia, Conduction; Anesthetics, Combined; Blood Pressure; Critical Ill | 2009 |
A prospective review of the use of ketamine to facilitate endotracheal intubation in the helicopter emergency medical services (HEMS) setting.
Topics: Adult; Air Ambulances; Alberta; Analgesics; Cohort Studies; Confidence Intervals; Critical Illness; | 2011 |
[Abnormal reaction for anaesthetics in a critically ill child with acute myeloid leukemia--case report].
Topics: Acute Disease; Anesthetics, Dissociative; Anti-Anxiety Agents; Benzodiazepines; Bone Marrow Transpla | 2004 |
Ketamine: its mechanism(s) of action and unusual clinical uses.
Topics: Analgesia; Anesthesia, Local; Anesthetics, Dissociative; Critical Illness; Humans; Ketamine; Pain, P | 1996 |
Effects of intravenous anesthetics on bacterial elimination in human blood in vitro.
Topics: Adult; Anesthetics, Dissociative; Anesthetics, Intravenous; Bacteremia; Blood Bactericidal Activity; | 1998 |
Combination propofol-ketamine anaesthesia in sick neonates.
Topics: Anesthesia, Intravenous; Anesthetics, Combined; Anesthetics, Dissociative; Anesthetics, Intravenous; | 2001 |