ketamine has been researched along with Consciousness, Loss of in 31 studies
Ketamine: A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.
ketamine : A member of the class of cyclohexanones in which one of the hydrogens at position 2 is substituted by a 2-chlorophenyl group, while the other is substituted by a methylamino group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Sevoflurane was initiated in both groups at 8% for anesthesia induction until loss of consciousness was achieved, at which point it was discontinued." | 6.80 | Effect of the Addition of Ketamine to Sevoflurane Anesthesia on Seizure Duration in Electroconvulsive Therapy. ( Çolak, C; Cumurcu, B; Durmus, M; Erdil, F; Ozgul, U, 2015) |
| "Ketamine anesthesia was associated with markedly increased genioglossus activity (1." | 3.78 | Ketamine activates breathing and abolishes the coupling between loss of consciousness and upper airway dilator muscle dysfunction. ( Bittner, EA; Chamberlin, NL; Eikermann, M; Grosse-Sundrup, M; Henry, ME; Hoffmann, U; Zaremba, S, 2012) |
| "Sevoflurane was initiated in both groups at 8% for anesthesia induction until loss of consciousness was achieved, at which point it was discontinued." | 2.80 | Effect of the Addition of Ketamine to Sevoflurane Anesthesia on Seizure Duration in Electroconvulsive Therapy. ( Çolak, C; Cumurcu, B; Durmus, M; Erdil, F; Ozgul, U, 2015) |
| "Ketamine is a noncompetitive N-methyl-D-aspartate antagonist and is known for unique electrophysiologic profiles in electroencephalography." | 1.56 | Dynamics of Ketamine-induced Loss and Return of Consciousness across Primate Neocortex. ( Ballesteros, JJ; Eskandar, EN; Huang, P; Ishizawa, Y; Patel, SR, 2020) |
| "Unconsciousness was induced either by intraperitoneal injection of ketamine or ethanol." | 1.56 | The arousal effect of hyperbaric oxygen through orexin/hypocretin an upregulation on ketamine/ethanol-induced unconsciousness in male rats. ( Bian, H; Hu, Q; Huang, L; Li, B; Liang, X; Tang, J; Zhang, JH, 2020) |
| " Dosage of each anesthetic agent was tailored to yield unresponsiveness (Ramsay score = 6)." | 1.51 | The spectral exponent of the resting EEG indexes the presence of consciousness during unresponsiveness induced by propofol, xenon, and ketamine. ( Boly, M; Boveroux, P; Brichant, JF; Casarotto, S; Chieregato, A; Colombo, MA; Gosseries, O; Laureys, S; Massimini, M; Napolitani, M; Rex, S; Rosanova, M; Sarasso, S, 2019) |
| "During ketamine-induced unconscious state, these distinct excitatory principal cell subtypes in both layer 2&3 and layer 5&6 exhibited distinct dynamics." | 1.46 | Distinct retrosplenial cortex cell populations and their spike dynamics during ketamine-induced unconscious state. ( Fox, GE; Li, M; Tsien, JZ; Zhao, F, 2017) |
| "For the low-frequency (3-6." | 1.43 | Changes in effective connectivity of sensorimotor rhythms in thalamocortical circuits during the induction and recovery of anesthesia in mice. ( Choi, JH; Hwang, E; Kang, JH; Kim, SP, 2016) |
| "Compared with the unconscious state, recovery of righting reflex was marked by a further increase in ACh concentrations (P=0." | 1.42 | Electroencephalographic coherence and cortical acetylcholine during ketamine-induced unconsciousness. ( Hambrecht-Wiedbusch, VS; Mashour, GA; Pal, D; Silverstein, BH, 2015) |
| "The point of loss of consciousness was indicated by a moment of loss of movement that was measured using a head-mounted motion sensor." | 1.38 | Changes in the thalamocortical connectivity during anesthesia-induced transitions in consciousness. ( Choi, JH; Hwang, E; Kang, JH; Kim, S; Kim, SP, 2012) |
| "Ketamine is a widely used dissociative anesthetic which can induce some psychotic-like symptoms and memory deficits in some patients during the post-operative period." | 1.36 | Temporal dynamics of distinct CA1 cell populations during unconscious state induced by ketamine. ( Kuang, H; Lin, L; Tsien, JZ, 2010) |
| "Ketamine is a safe and effective sedative for diagnostic or therapeutic procedures in the Emergency Department." | 1.35 | Prolonged sedation and airway complications after administration of an inadvertent ketamine overdose in emergency department. ( Benito, J; Capapé, S; García, S; Mintegui, S; Mora, E; Santiago, M, 2008) |
| "Melatonin pre-treatment affected in a dual manner barbiturate narcosis, however, no dose-effect correlation was found." | 1.31 | Dual effects of melatonin on barbiturate-induced narcosis in rats. ( Drago, F; Foti, F; Frisina, M; Grech, M; Medico, M; Micale, V; Nicolosi, A; Nicosia, A, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (12.90) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (9.68) | 29.6817 |
| 2010's | 17 (54.84) | 24.3611 |
| 2020's | 7 (22.58) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, Y | 1 |
| Li, S | 1 |
| Liang, X | 2 |
| Zhang, J | 1 |
| Leung, LS | 1 |
| Ma, J | 1 |
| Fehrlin, ES | 1 |
| Hight, D | 1 |
| Kaiser, HA | 1 |
| Luedi, MM | 1 |
| Huber, M | 1 |
| Zubler, F | 1 |
| Lersch, F | 1 |
| Radovanovic, L | 1 |
| Novakovic, A | 1 |
| Petrovic, J | 1 |
| Saponjic, J | 1 |
| Ballesteros, JJ | 1 |
| Huang, P | 1 |
| Patel, SR | 1 |
| Eskandar, EN | 1 |
| Ishizawa, Y | 1 |
| Costa, YRS | 1 |
| Lavorato, SN | 1 |
| Baldin, JJCMC | 1 |
| Wang, J | 1 |
| Noh, GJ | 1 |
| Choi, BM | 1 |
| Ku, SW | 1 |
| Joo, P | 1 |
| Jung, WS | 1 |
| Kim, S | 4 |
| Lee, H | 1 |
| Fox, GE | 1 |
| Li, M | 1 |
| Zhao, F | 1 |
| Tsien, JZ | 2 |
| Kim, H | 1 |
| Moon, JY | 1 |
| Mashour, GA | 2 |
| Lee, U | 1 |
| Colombo, MA | 1 |
| Napolitani, M | 1 |
| Boly, M | 1 |
| Gosseries, O | 1 |
| Casarotto, S | 1 |
| Rosanova, M | 1 |
| Brichant, JF | 1 |
| Boveroux, P | 1 |
| Rex, S | 1 |
| Laureys, S | 1 |
| Massimini, M | 1 |
| Chieregato, A | 1 |
| Sarasso, S | 1 |
| Finley, J | 1 |
| Alonso, LM | 1 |
| Solovey, G | 1 |
| Yanagawa, T | 1 |
| Proekt, A | 1 |
| Cecchi, GA | 1 |
| Magnasco, MO | 1 |
| Bian, H | 1 |
| Huang, L | 1 |
| Li, B | 1 |
| Hu, Q | 1 |
| Tang, J | 1 |
| Zhang, JH | 1 |
| Erdil, F | 1 |
| Ozgul, U | 2 |
| Çolak, C | 1 |
| Cumurcu, B | 1 |
| Durmus, M | 1 |
| Pal, D | 1 |
| Hambrecht-Wiedbusch, VS | 1 |
| Silverstein, BH | 1 |
| Kang, JH | 2 |
| Choi, JH | 4 |
| Hwang, E | 4 |
| Kim, SP | 2 |
| Shin, HS | 1 |
| Chiou, RJ | 1 |
| Kuo, CC | 1 |
| Liang, KC | 1 |
| Yen, CT | 1 |
| Kuang, H | 1 |
| Lin, L | 1 |
| Canet, J | 1 |
| Castillo, J | 1 |
| Eikermann, M | 1 |
| Grosse-Sundrup, M | 1 |
| Zaremba, S | 1 |
| Henry, ME | 1 |
| Bittner, EA | 1 |
| Hoffmann, U | 1 |
| Chamberlin, NL | 1 |
| Erdogan Kayhan, G | 1 |
| Yucel, A | 1 |
| Colak, YZ | 1 |
| Yologlu, S | 1 |
| Karlıdag, R | 1 |
| Ersoy, MO | 1 |
| Lettieri, C | 1 |
| Rinaldo, S | 1 |
| Devigili, G | 1 |
| Pauletto, G | 1 |
| Verriello, L | 1 |
| Budai, R | 1 |
| Fadiga, L | 1 |
| Oliynyk, A | 1 |
| Mondani, M | 1 |
| D'Auria, S | 1 |
| Skrap, M | 1 |
| Eleopra, R | 1 |
| Han, K | 1 |
| Capapé, S | 1 |
| Mora, E | 1 |
| Mintegui, S | 1 |
| García, S | 1 |
| Santiago, M | 1 |
| Benito, J | 1 |
| Drago, F | 1 |
| Frisina, M | 1 |
| Grech, M | 1 |
| Nicolosi, A | 1 |
| Micale, V | 1 |
| Nicosia, A | 1 |
| Medico, M | 1 |
| Foti, F | 1 |
| Suriani, U | 1 |
| Di Marco, MG | 1 |
| Franceschelli, N | 1 |
| Lamma, A | 1 |
| Macchiagodena, C | 1 |
| Monti, B | 1 |
| Milam, SB | 1 |
| Amiot, JF | 2 |
| Bouju, P | 2 |
| Palacci, JH | 2 |
| Balliner, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of S-ketamine on Depressed Patients Undergoing Electroconvulsive Therapy-a Randomized, Double-blind, Controlled Clinical Study[NCT04399070] | 150 participants (Anticipated) | Interventional | 2020-08-01 | Not yet recruiting | |||
| The Effects of Subanesthetic Ketamine on Respiratory Stimulation and Transpulmonary Pressures in Mechanically Ventilated Critically Ill Patients[NCT01969227] | 15 participants (Actual) | Interventional | 2014-01-31 | Completed | |||
| The Effects of Sevoflurane, Propofol, and Carbon Dioxide 'Reversal' on Upper Airway Collapsibility in Healthy, Adult Subjects[NCT01557920] | Phase 4 | 18 participants (Actual) | Interventional | 2013-01-31 | Completed | ||
| Inonu University Faculty of Medicine Department of Anesthesiology and Reanimation[NCT02819375] | Phase 4 | 45 participants (Actual) | Interventional | 2017-01-31 | Completed | ||
| Arousal Pathways and Emergence From Sedation[NCT02253758] | 20 participants (Anticipated) | Interventional | 2014-10-31 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(T(ins)/T(total))*100 (NCT01557920)
Timeframe: Will be measured before and during anesthesia until emergence from anesthesia, an expected average of 6 hours
| Intervention | percentage of Ttotal (Mean) |
|---|---|
| Wakefulness | 42 |
| Anesthesia With Low Dose Sevoflurane (Baseline CO2) | 42 |
| Anesthesia With High Dose Sevoflurane (Baseline CO2) | 43 |
| Anesthesia With Low Dose Propofol (CO2 Baseline) | 40 |
| Anesthesia With High Dose Propofol (CO2 Baseline) | 41 |
The number of swallows were counted during wakefulness and anesthesia. The frequency of swallowing was calculated per hour (NCT01557920)
Timeframe: swallows were measured during steady state conditions (mean±SEM, 2.6±0.6h)
| Intervention | number of swallows/hr (Mean) |
|---|---|
| Anesthesia With Propofol and Sevoflurane | 1.7 |
| Wakefulness | 28 |
will be measured during steady state anesthesia as well as during carbon dioxide reversal, and during recovery from anesthesia. (NCT01557920)
Timeframe: participants will be followed for the duration of anesthesia until full recovery, an expected average of 9 hours
| Intervention | percentage of maximum recorded activity (Mean) |
|---|---|
| Phasic Genioglossus Activity (Light Anesthesia) | 32.8 |
| Tonic Genioglossus Activity (Light Anesthesia) | 24.2 |
| Phasic Genioglossus Activity (Deep Anesthesia) | 26.0 |
| Tonic Genioglossus Activity (Deep Anesthesia) | 22.3 |
Measured by spirometry. Subjects wear a full-face mask. Reported in L/min (NCT01557920)
Timeframe: Will be measured before and during anesthesia until emergence from anesthesia, an expected average of 6 hours
| Intervention | L/min (Mean) |
|---|---|
| Wakefulness | 7.9 |
| Anesthesia With Low Dose Sevoflurane (Baseline CO2) | 6.7 |
| Anesthesia With High Dose Sevoflurane (Baseline CO2) | 5.6 |
| Anesthesia With Low Dose Propofol (CO2 Baseline) | 7.2 |
| Anesthesia With High Dose Propofol (CO2 Baseline) | 5.7 |
A pathological swallow was defined as a swallow that was followed by inspiratory flow. A physiological swallow was defined as a swallow that was followed by expiratory flow. The number of pathological and physiological swallows were measured during wakefulness and anesthesia. The pathological swallows are presented as percentage of path. swallows calculated as path.sw/[path.sw+phys.sw]*100 (%). (NCT01557920)
Timeframe: swallows were measured during steady state conditions (mean±SEM, 2.6±0.6h)
| Intervention | percentage of pathological swallows (Number) |
|---|---|
| Anesthesia With Propofol and Sevoflurane (All Cases) | 25.9 |
| Wakefulness (All Cases) | 4.9 |
| Anesthesia With Propofol and Sevoflurane (Baseline CO2) | 15.8 |
| Anesthesia With Propofol and Sevoflurane (CO2 Insufflation) | 34.9 |
| Wakefulness (During Baseline CO2) | 1.0 |
| Wakefulness (With CO2 Insufflation) | 13.2 |
Upper airway closing pressure will be measured during steady state anesthesia as well as during carbon dioxide reversal. (NCT01557920)
Timeframe: participants will be followed for the duration of anesthesia, an expected average of 6 hours
| Intervention | cm H20 (Mean) |
|---|---|
| Propofol | -9.83 |
| Sevoflurane | -10.77 |
2 reviews available for ketamine and Consciousness, Loss of
| Article | Year |
|---|---|
Medial Septum Modulates Consciousness and Psychosis-Related Behaviors Through Hippocampal Gamma Activity.
Topics: Animals; Consciousness; Electroencephalography; Gamma Rays; Hippocampus; Humans; Ketamine; Psychotic | 2022 |
Violence against women and drug-facilitated sexual assault (DFSA): A review of the main drugs.
Topics: Adjuvants, Anesthesia; Alcohol Drinking; Anesthetics, Dissociative; Benzodiazepines; Crime Victims; | 2020 |
2 trials available for ketamine and Consciousness, Loss of
| Article | Year |
|---|---|
Effect of the Addition of Ketamine to Sevoflurane Anesthesia on Seizure Duration in Electroconvulsive Therapy.
Topics: Adult; Anesthesia; Anesthesia Recovery Period; Anesthetics, Dissociative; Anesthetics, Inhalation; A | 2015 |
Ketofol (mixture of ketamine and propofol) administration in electroconvulsive therapy.
Topics: Adult; Anesthesia; Anesthetics, Dissociative; Anesthetics, Intravenous; Blood Pressure; Double-Blind | 2012 |
27 other studies available for ketamine and Consciousness, Loss of
| Article | Year |
|---|---|
Differential Alterations to the Metabolic Connectivity of the Cortical and Subcortical Regions in Rat Brain During Ketamine-Induced Unconsciousness.
Topics: Anesthetics, Intravenous; Animals; Brain; Fluorodeoxyglucose F18; Glucose; Ketamine; Propofol; Rats; | 2022 |
A Pilot Investigation Evaluating Relative Changes in Fronto-Occipital Alpha and Beta Spectral Power as Measurement of Anesthesia Hypnotic Depth.
Topics: Anesthesia, General; Electroencephalography; Humans; Hypnotics and Sedatives; Ketamine; Pilot Projec | 2023 |
Different Alterations of Hippocampal and Reticulo-Thalamic GABAergic Parvalbumin-Expressing Interneurons Underlie Different States of Unconsciousness.
Topics: Animals; Diazepam; Hippocampus; Interneurons; Ketamine; Parvalbumins; Propofol; Rats; Unconsciousnes | 2023 |
Dynamics of Ketamine-induced Loss and Return of Consciousness across Primate Neocortex.
Topics: Anesthetics, Dissociative; Animals; Consciousness; Electroencephalography; Excitatory Amino Acid Ant | 2020 |
Suppressed neural complexity during ketamine- and propofol-induced unconsciousness.
Topics: Adult; Anesthetics, Intravenous; Cerebral Cortex; Electroencephalography; Female; Humans; Ketamine; | 2017 |
Distinct retrosplenial cortex cell populations and their spike dynamics during ketamine-induced unconscious state.
Topics: Action Potentials; Animals; Excitatory Amino Acid Antagonists; Ketamine; Mice; Neurons; Sleep; Uncon | 2017 |
Mechanisms of hysteresis in human brain networks during transitions of consciousness and unconsciousness: Theoretical principles and empirical evidence.
Topics: Adult; Anesthetics, General; Brain; Connectome; Consciousness; Cortical Synchronization; Electroence | 2018 |
The spectral exponent of the resting EEG indexes the presence of consciousness during unresponsiveness induced by propofol, xenon, and ketamine.
Topics: Adolescent; Adult; Anesthetics, General; Brain Waves; Consciousness; Electroencephalography; Female; | 2019 |
Cellular stress and AMPK links metformin and diverse compounds with accelerated emergence from anesthesia and potential recovery from disorders of consciousness.
Topics: AMP-Activated Protein Kinases; Anesthesia; Anesthesia Recovery Period; Anesthetics; Animals; Brain M | 2019 |
Single-trial classification of awareness state during anesthesia by measuring critical dynamics of global brain activity.
Topics: Anesthesia; Animals; Awareness; Brain; Consciousness; Cortical Excitability; Electrocorticography; E | 2019 |
The arousal effect of hyperbaric oxygen through orexin/hypocretin an upregulation on ketamine/ethanol-induced unconsciousness in male rats.
Topics: Animals; Arousal; Benzoxazoles; Dioxanes; Ethanol; Hyperbaric Oxygenation; Ketamine; Male; Naphthyri | 2020 |
Electroencephalographic coherence and cortical acetylcholine during ketamine-induced unconsciousness.
Topics: Acetylcholine; Anesthesia Recovery Period; Anesthetics, Dissociative; Animals; Behavior, Animal; Cer | 2015 |
Changes in effective connectivity of sensorimotor rhythms in thalamocortical circuits during the induction and recovery of anesthesia in mice.
Topics: Analgesics; Anesthesia; Animals; Brain Waves; Electroencephalography; Ketamine; Male; Mice; Mice, In | 2016 |
The forced walking test: a novel test for pinpointing the anesthetic-induced transition in consciousness in mouse.
Topics: Anesthesia; Anesthesia Recovery Period; Anesthetics; Animals; Behavior, Animal; Brain; Electroenceph | 2010 |
State-dependent amygdala stimulation-induced cardiovascular effects in rats.
Topics: Amygdala; Anesthetics, General; Animals; Blood Pressure; Cardiovascular Physiological Phenomena; Chl | 2009 |
Temporal dynamics of distinct CA1 cell populations during unconscious state induced by ketamine.
Topics: Analgesics; Anesthesia; Animals; Electrophysiology; Hippocampus; Interneurons; Ketamine; Male; Mice; | 2010 |
Ketamine: a familiar drug we trust.
Topics: Anesthetics, Dissociative; Animals; Ketamine; Male; Respiration; Respiratory Muscles; Unconsciousnes | 2012 |
Ketamine activates breathing and abolishes the coupling between loss of consciousness and upper airway dilator muscle dysfunction.
Topics: Anesthesia; Anesthesia, Intravenous; Anesthetics, Dissociative; Anesthetics, Intravenous; Animals; B | 2012 |
Ketamine activates breathing and abolishes the coupling between loss of consciousness and upper airway dilator muscle dysfunction.
Topics: Anesthesia; Anesthesia, Intravenous; Anesthetics, Dissociative; Anesthetics, Intravenous; Animals; B | 2012 |
Ketamine activates breathing and abolishes the coupling between loss of consciousness and upper airway dilator muscle dysfunction.
Topics: Anesthesia; Anesthesia, Intravenous; Anesthetics, Dissociative; Anesthetics, Intravenous; Animals; B | 2012 |
Ketamine activates breathing and abolishes the coupling between loss of consciousness and upper airway dilator muscle dysfunction.
Topics: Anesthesia; Anesthesia, Intravenous; Anesthetics, Dissociative; Anesthetics, Intravenous; Animals; B | 2012 |
Changes in the thalamocortical connectivity during anesthesia-induced transitions in consciousness.
Topics: Anesthetics, Dissociative; Animals; Consciousness; Electroencephalography; Hypnotics and Sedatives; | 2012 |
Deep brain stimulation: Subthalamic nucleus electrophysiological activity in awake and anesthetized patients.
Topics: Aged; Anesthesia, General; Anesthesia, Local; Deep Brain Stimulation; Female; Humans; Ketamine; Male | 2012 |
Characterization of phase transition in the thalamocortical system during anesthesia-induced loss of consciousness.
Topics: Anesthesia; Animals; Cerebral Cortex; Consciousness; Electrophysiology; Ketamine; Male; Mice; Thalam | 2012 |
Prolonged sedation and airway complications after administration of an inadvertent ketamine overdose in emergency department.
Topics: Airway Obstruction; Anesthetics, Dissociative; Child, Preschool; Drug Overdose; Humans; Injections, | 2008 |
Dual effects of melatonin on barbiturate-induced narcosis in rats.
Topics: Adjuvants, Anesthesia; Anesthetics, Dissociative; Animals; Antioxidants; Barbiturates; Diazepam; Dos | 2001 |
[Use of ketamine in pediatrics. ORL surgery and minor eye surgery, studies on evoked visual and auditive potentials, skull radiographic studies, hrt catheterization].
Topics: Adolescent; Age Factors; Cardiac Catheterization; Child; Child, Preschool; Ear Diseases; Evoked Pote | 1977 |
Pain control in dentistry: general anesthesia.
Topics: Analgesia; Anesthesia, Dental; Anesthesia, General; Anesthesia, Inhalation; Anesthesia, Intravenous; | 1986 |
Effect of naloxone on loss of consciousness induced by i.v. ketamine.
Topics: Female; Humans; Ketamine; Naloxone; Pregnancy; Unconsciousness | 1985 |
Intravenous regional anaesthesia with ketamine.
Topics: Adult; Anesthesia, Conduction; Anesthesia, Intravenous; Humans; Ketamine; Tourniquets; Unconsciousne | 1985 |