ketamine has been researched along with Pain, Postoperative in 694 studies
Ketamine: A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.
ketamine : A member of the class of cyclohexanones in which one of the hydrogens at position 2 is substituted by a 2-chlorophenyl group, while the other is substituted by a methylamino group.
Pain, Postoperative: Pain during the period after surgery.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Ninety-two patients undergoing laparoscopic radical resection of colorectal cancer were randomly assigned to either the esketamine (K group) or non-eskatamine (C group) group." | 9.69 | Intraoperative intravenous low-dose esketamine improves quality of early recovery after laparoscopic radical resection of colorectal cancer: A prospective, randomized controlled trial. ( Ai, Y; He, L; Liu, S; Xu, Y; Zhang, C, 2023) |
| "The mini-dose esketamine-dexmedetomidine combination safely improved analgesia and subjective sleep quality after scoliosis correction surgery." | 9.69 | Mini-dose esketamine-dexmedetomidine combination to supplement analgesia for patients after scoliosis correction surgery: a double-blind randomised trial. ( Cui, F; Ma, JH; Wang, DX; Zhang, Y, 2023) |
| "This study aimed at examining the effect of a single sub-anesthetic dose of ketamine on postoperative fatigue syndrome (POFS) in patients undergoing radical laparoscopic surgery for colorectal cancer (CRC)." | 9.51 | Effect of a single sub-dose of ketamine on postoperative fatigue syndrome in colorectal cancer patients undergoing radical laparoscopic surgery: A double-blind, pilot study. ( Cheng, H; Zhang, H; Zhao, L, 2022) |
| " S(+)-ketamine is an N-methyl-D-aspartic acid (NMDA) receptor antagonist with a strong analgesic effect and can significantly relieve postoperative acute pain and reduce opioid consumption." | 9.51 | Evaluation of the effect of perioperative administration of S(+)-ketamine hydrochloride injection for postoperative acute pain in children: study protocol for a prospective, multicenter, randomized, open-label, parallel-group, pragmatic clinical trial. ( Chen, P; Duan, C; Lan, C; Mi, W; Qu, S; Sun, Y; Wang, H; Yang, L; Zhang, J; Zhou, L, 2022) |
| "The Ketamine for Acute Pain Management After Trauma (KAPT) with registration # NCT04129086 was registered on October 16, 2019." | 9.51 | Ketamine for acute pain after trauma: the KAPT randomized controlled trial. ( Balogh, J; Green, C; Harvin, JA; Kao, LS; Klugh, J; Prater, SJ; Puzio, TJ; Sergot, PB; Stephens, CT; Wade, CE; Wandling, MW, 2022) |
| "Intraoperative low-dose ketamine infusion did not improve the overall quality of recovery on POD 1 in patients undergoing breast cancer surgery." | 9.41 | The effect of low-dose ketamine on postoperative quality of recovery in patients undergoing breast cancer surgery: A randomised, placebo-controlled trial. ( Cao, J; Chen, Y; Han, Y; Liu, C; Xu, Q; Zhang, F; Zhao, Z, 2021) |
| "This study aims to investigate the effect of the pretreatment of S-ketamine on postoperative depression (POD) for breast cancer patients with mild/moderate depression." | 9.41 | Effect of Pretreatment of S-Ketamine On Postoperative Depression for Breast Cancer Patients. ( Li, P; Li, Q; Liu, C; Liu, P; Peng, S; Shi, X; Yan, H; Zhang, Y, 2021) |
| "The aim of this clinical trial was to test if intraoperative low-dose ketamine without postoperative infusion would reduce PPSP development after breast cancer surgery." | 9.34 | Effects of Intraoperative Low-Dose Ketamine on Persistent Postsurgical Pain after Breast Cancer Surgery: A Prospective, Randomized, Controlled, Double-Blind Study. ( Baik, JS; Cho, AR; Kang, C; Kim, C; Kim, E; Kim, H; Kim, KH; Kwon, JY; Lee, EA; Lee, HJ, 2020) |
| "BACKGROUND This study investigated the effects of various doses of S-ketamine on depression and pain management of cervical carcinoma patients with mild/moderate depression." | 9.34 | Use of Various Doses of S-Ketamine in Treatment of Depression and Pain in Cervical Carcinoma Patients with Mild/Moderate Depression After Laparoscopic Total Hysterectomy. ( Liu, P; Peng, S; Wang, J; Wang, Y; Xu, F; Xu, X, 2020) |
| "A single subanaesthetic dose of ketamine did not decrease delirium in older adults after major surgery, and might cause harm by inducing negative experiences." | 9.24 | Intraoperative ketamine for prevention of postoperative delirium or pain after major surgery in older adults: an international, multicentre, double-blind, randomised clinical trial. ( Abdallah, AB; Arya, VK; Avidan, MS; Downey, RJ; Emmert, DA; Fritz, BA; Grocott, HP; Hudetz, JA; Inouye, SK; Jacobsohn, E; Lee, YH; Mashour, GA; Maybrier, HR; Muench, MR; Noh, GJ; Pagel, PS; Pryor, KO; Rogers, EM; Veselis, RA; Vlisides, PE; Waberski, W; Waszynski, CM; Yulico, H, 2017) |
| "A total of 48 pediatric patients between 10 and 18 years diagnosed with idiopathic scoliosis were randomized to receive perioperative low-dose ketamine or placebo for 72 hours." | 9.24 | Prolonged Perioperative Low-Dose Ketamine Does Not Improve Short and Long-term Outcomes After Pediatric Idiopathic Scoliosis Surgery. ( Artés, D; Esteban, E; Ey Batlle, AM; Pascuets, C; Perelló, M, 2017) |
| " Here, we utilize fragility indices to assess the statistical robustness of RCTs evaluating low-dose ketamine during scoliosis surgery to reduce opioid tolerance and postoperative pain." | 9.22 | Statistical Fragility of Ketamine Infusion During Scoliosis Surgery to Reduce Opioid Tolerance and Postoperative Pain. ( Al Farii, H; Gupta, A; Mo, K; Movsik, J, 2022) |
| "In this meta-analysis, we aim to compare ketamine use versus a control group (saline solution) during induction of anesthesia in adolescent idiopathic scoliosis patients undergoing fusion surgery in terms of postoperative opioid consumption, pain control, and side effects." | 9.22 | Meta-analysis of the efficacy of ketamine in postoperative pain control in adolescent idiopathic scoliosis patients undergoing spinal fusion. ( Bas, JL; Bas, P; Bas, T; Bovea-Marco, M; Mariscal, G; Morales, J; Pérez, S; Rubio-Belmar, PA, 2022) |
| "In this randomized controlled trial, we examined whether intra- and postoperative infusion of low-dose ketamine decreased postoperative morphine requirement and morphine-related adverse effects as nausea and vomiting after scoliosis surgery." | 9.20 | Intra- and postoperative low-dose ketamine for adolescent idiopathic scoliosis surgery: a randomized controlled trial. ( Hashiguchi, S; Ihara, N; Katori, N; Kosugi, S; Minoshima, R; Morisaki, H; Nishimura, D; Seki, H; Watanabe, K; Yamada, T, 2015) |
| "Adding epidural or IV racemic ketamine to TEA after thoracotomy did not lead to any reduction in PPP or allodynia." | 9.19 | Perioperative epidural or intravenous ketamine does not improve the effectiveness of thoracic epidural analgesia for acute and chronic pain after thoracotomy. ( Gomar, C; Rios, J; Tena, B, 2014) |
| "Ketamine and magnesium association reduces the post-operative morphine consumption after scoliosis surgery." | 9.19 | Ketamine and magnesium association reduces morphine consumption after scoliosis surgery: prospective randomised double-blind study. ( Abou Zeid, HA; Ghanem, IB; Jabbour, HJ; Jabbour, KB; Jawish, RJ; Naccache, NM; Rabbaa-Khabbaz, LG; Yazbeck, PH, 2014) |
| " A number of clinical trials provide evidence that the perioperative use of subanesthetic doses of ketamine reduces pain and opioid requirements in some surgical procedures, but the effect of prolonged perioperative low-dose ketamine infusion in patients undergoing posterior spinal fusion for pediatric scoliosis surgery is unknown." | 9.19 | Prolonged perioperative infusion of low-dose ketamine does not alter opioid use after pediatric scoliosis surgery. ( Cheng, Y; Finkel, JC; Junqueira, MM; Lovejoy, JF; Pestieau, SR; Quezado, Z; Wang, J, 2014) |
| "To evaluate the postoperative analgesia after surgical site infiltration with bupivacaine or ketamine in children undergoing cleft palate surgery." | 9.17 | A randomized study of surgical site infiltration with bupivacaine or ketamine for pain relief in children following cleft palate repair. ( Bhardwaj, N; Jha, AK; Mahajan, JK; Sharma, RK; Yaddanapudi, S, 2013) |
| "Dexmedetomidine and ketamine appear to prevent postoperative agitation and pain after sevoflurane anesthesia for pediatric strabismus surgery." | 9.17 | Comparison of the effects of dexmedetomidine, ketamine, and placebo on emergence agitation after strabismus surgery in children. ( Chen, JY; Jia, JE; Li, WX; Liu, TJ; Qin, MJ, 2013) |
| "These findings suggest that the routine use of a single dose of ketamine prior to chest wall incision is not effective at reducing pain or inflammation in thoracic surgery patients at 24 h postoperatively." | 9.15 | A randomized, double blind, placebo controlled clinical trial of the preoperative use of ketamine for reducing inflammation and pain after thoracic surgery. ( Bennett-Guerrero, E; D'Alonzo, RC; D'Amico, TA; Harpole, DH; Podgoreanu, M; Shaw, AD, 2011) |
| "Thirty-four adolescents aged 12-18 yr scheduled for scoliosis surgery were randomly assigned to receive intraoperative low-dose ketamine (bolus dose of 0." | 9.13 | Intraoperative low-dose ketamine does not prevent a remifentanil-induced increase in morphine requirement after pediatric scoliosis surgery. ( Crawford, MW; de Ruiter, J; Engelhardt, T; Howard, A; Naser, B; Pehora, C; Zaarour, C, 2008) |
| "This study was designed to investigate whether the addition of tramadol or lidocaine to ketamine would enhance the quality of intra- and postoperative analgesia for hypospadias surgery in children." | 9.12 | Comparison of caudal ketamine with lidocaine or tramadol administration for postoperative analgesia of hypospadias surgery in children. ( Gunduz, M; Ozalevli, M; Ozbek, H; Ozcengiz, D, 2006) |
| "The analgesic efficiency of ketamine and pethidine was compared in experimental ischemic pain and postoperative pain after oral surgery." | 9.06 | Comparison of ketamine and pethidine in experimental and postoperative pain. ( Hustveit, O; Maurset, A; Skoglund, LA; Øye, I, 1989) |
| "To evaluate the efficacy and safety of perioperative intravenous ketamine in adult patients when used for the treatment or prevention of acute pain following general anaesthesia." | 8.98 | Perioperative intravenous ketamine for acute postoperative pain in adults. ( Bell, RF; Brinck, EC; Heesen, M; Kontinen, V; Moore, RA; Straube, S; Tiippana, E, 2018) |
| "In conclusion, these meta-analyses of nine trials confirm that ketamine and magnesium, differently but consistently, reduce hemodynamic variability during surgery and may be seen as complementary not only for pain control but also to provide stable anesthesia." | 8.95 | Stable anesthesia with alternative to opioids: Are ketamine and magnesium helpful in stabilizing hemodynamics during surgery? A systematic review and meta-analyses of randomized controlled trials. ( Cata, J; Forget, P, 2017) |
| "The present study evaluated the effects of ketamine in rats with the comorbidity of CPSP and depression." | 7.96 | Ketamine relieves depression-like behaviors induced by chronic postsurgical pain in rats through anti-inflammatory, anti-oxidant effects and regulating BDNF expression. ( Liu, Y; Ma, P; Ma, T; Song, Y; Yang, Y; Zhang, H; Zhang, X; Zhao, W; Zhao, Y, 2020) |
| "The objective of this systematic review is to examine the best available evidence on the clinical effectiveness of ketamine as an adjuvant to opioid-based therapy versus opioid-based therapy alone in decreasing perioperative pain associated with opioid tolerance in adult patients, aged 18-70 years, undergoing orthopedic surgical procedures." | 7.83 | Effectiveness of ketamine as an adjuvant to opioid-based therapy in decreasing pain associated with opioid tolerance in adults undergoing orthopedic surgery: a systematic review protocol. ( Bennett, M; Bonanno, L; Kuhn, W, 2016) |
| "We evaluated the effect of ketamine-xylazine-acepromazine anesthesia (31." | 7.73 | Ketamine-xylazine-acepromazine anesthesia and postoperative recovery in rats. ( Huerkamp, MJ; Kinkead, B; Nemeroff, CB; Plotsky, PM; Thrivikraman, K; Welberg, LA, 2006) |
| "We examined the analgesic effect of racemic ketamine and its 2 enantiomers in 16 female patients (age: 20-29 years) suffering acute pain after oral surgery and in 7 female patients (age: 42-79 years) suffering chronic neuropathic orofacial pain." | 7.69 | Effect of ketamine, an NMDA receptor inhibitor, in acute and chronic orofacial pain. ( Mathisen, LC; Skjelbred, P; Skoglund, LA; Øye, I, 1995) |
| "This study was done to investigate the effectiveness and safety of ketamine analgesia after halothane anesthesia for surgery in children." | 7.67 | Postoperative ketamine analgesia in children: efficacy and safety after halothane anesthesia. ( Forestner, JE, 1988) |
| " Secondary endpoints are postoperative NRS scores, the anaesthesia recovery time, time of first rescue analgesia, the incidence of rescue analgesia, the incidence of postoperative delirium, patient questionnaire for effect, changes from baseline in cognitive function and anxiety and depression, as well as the adverse events and pharmacoeconomic outcomes." | 7.01 | Perioperative intravenous S(+)-ketamine for acute postoperative pain in adults: study protocol for a multicentre, randomised, open-label, positive-controlled, pragmatic clinical trial (SAFE-SK-A trial). ( Chen, PY; Chu, HC; Diao, YG; Duan, CY; Hua, Z; Huang, WQ; Li, H; Liu, CM; Liu, YH; Meng, QT; Mi, WD; Wang, H; Wang, Q; Zhang, XY; Zhao, P; Zhou, LZ, 2021) |
| " Secondary outcomes included postoperative visual analog scale (VAS) scores for pain and adverse effects associated with ketamine." | 7.01 | Efficacy and safety of perioperative application of ketamine on postoperative depression: A meta-analysis of randomized controlled studies. ( Gu, HW; Guo, J; Hashimoto, K; Qiu, D; Wang, XM; Yang, JJ; Zhang, GF, 2023) |
| "Ketamine has shown promise to have both opioid sparing and analgesic effects in the postoperative setting." | 6.94 | The efficacy of ketamine for postoperative pain control in adolescent patients undergoing spinal fusion surgery for idiopathic scoliosis. ( Afroze, F; Carl, A; Ehlers, M; Feustel, P; Leduc, L; Metcalfe, B; Pomerantz, M; Ricciardelli, RM; Silverman, E; Walters, NM, 2020) |
| "Secondary outcome measures are postoperative pain intensity scores, psychological parameters, length of hospital stay and adverse events and will be reassessed at 3 and 6 months after surgery, with a baseline measurement preoperatively." | 6.90 | Assessing the effectiveness of perioperative s-ketamine on new-onset headache after resective epilepsy surgery (ESPAIN-trial): protocol for a randomised, double-blind, placebo-controlled trial. ( Bastiaenen, C; Bos, M; Colon, A; Dings, J; Hoogland, G; Rijkers, K; Rouhl, RPW; Schijns, OEMG; Sloekers, JCT; Theunissen, M; van Kuijk, S, 2019) |
| " To reduce the risk for potential psychodysleptic side effects, however, ketamine dosing tends to be limited to low-dose regimens." | 6.82 | The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial. ( Bornemann-Cimenti, H; Edler, A; Michaeli, K; Sandner-Kiesling, A; Wejbora, M, 2016) |
| "Ketamine is a phencyclidine derivative that induces a state of dissociative anesthesia." | 6.80 | A Comparative Study between the Effect of Combined Local Anesthetic and Low-dose Ketamine with Local Anesthetic on Postoperative Complications after Impacted Third Molar Surgery. ( Kale, TP; Kumar, A, 2015) |
| "patient-controlled analgesia (IV-PCA) on postoperative nausea and vomiting (PONV) in patients at high risk of PONV undergoing lumbar spinal surgery." | 6.78 | Effect of ketamine as an adjunct to intravenous patient-controlled analgesia, in patients at high risk of postoperative nausea and vomiting undergoing lumbar spinal surgery. ( Kwak, YL; Park, SJ; Shim, JK; Song, JW; Song, Y; Yang, SY, 2013) |
| "Ketamine is an adjuvant demonstrating analgesic and opioid-sparing effects." | 6.78 | Ketamine decreases postoperative pain scores in patients taking opioids for chronic pain: results of a prospective, randomized, double-blind study. ( Barreveld, AM; Correll, DJ; Liu, X; Max, B; McGowan, JA; Nedeljkovic, SS; Shovel, L; Wasan, AD, 2013) |
| " The aim of this study was to evaluate the effect of oral ketamine on the dosage of local anesthetics required and postoperative pain management for irreversibly inflamed mandibular molars." | 6.76 | The effect of orally administered ketamine on requirement for anesthetics and postoperative pain in mandibular molar teeth with irreversible pulpitis. ( Ebtehaj, I; Kaviani, N; Khademi, A; Mohammadi, Z, 2011) |
| "Ketamine is an N-methyl-d-aspartate receptor antagonist that has been shown to be useful in the reduction of acute postoperative pain and analgesic consumption in a variety of surgical interventions with variable routes of administration." | 6.75 | Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery. ( Abdu, WA; Beach, ML; Brown, JR; Clark, JA; Loftus, RW; Sengupta, DK; Yeager, MP, 2010) |
| "Opioids contribute to postoperative nausea and vomiting (PONV)." | 6.70 | [Recovery from anaesthesia and incidence and intensity of postoperative nausea and vomiting following a total intravenous anaesthesia (TIVA) with S-(+)-ketamine/propofol compared to alfentanil/propofol]. ( Hering, W; Kessebohm, K; Kundt, HJ; Schmid, M; St Pierre, M, 2002) |
| " Predefined subgroup analyses and meta-regression did not detect significant differences across subgroups, including a dose-response relationship." | 6.53 | Ketamine added to morphine or hydromorphone patient-controlled analgesia for acute postoperative pain in adults: a systematic review and meta-analysis of randomized trials. ( Cheng, D; Johnston, B; Kaushal, A; Martin, J; Wang, L; Zhu, F, 2016) |
| "Only the analysis of postoperative pain at rest after 1 month resulted in a marginally significant reduction of chronic postoperative pain using ketamine in the perioperative setting." | 6.52 | Intra- and postoperative intravenous ketamine does not prevent chronic pain: A systematic review and meta-analysis. ( Bandschapp, O; Girard, T; Klatt, E; Ruppen, W; Zumbrunn, T, 2015) |
| "patient-controlled analgesia (PCA) for postoperative pain in order to clarify this controversy." | 6.46 | Adding ketamine to morphine for intravenous patient-controlled analgesia for acute postoperative pain: a qualitative review of randomized trials. ( Carstensen, M; Møller, AM, 2010) |
| "Ketamine also reduces postoperative nausea and vomiting." | 6.43 | Perioperative ketamine for acute postoperative pain. ( Bell, RF; Dahl, JB; Kalso, E; Moore, RA, 2006) |
| "Ketamine hydrochloride is a well known general anesthetic and short acting analgesic in use for almost 3 decades." | 6.40 | Use and efficacy of low-dose ketamine in the management of acute postoperative pain: a review of current techniques and outcomes. ( Katz, J; Sandler, AN; Schmid, RL, 1999) |
| " Ninety-two patients undergoing laparoscopic radical resection of colorectal cancer were randomly assigned to either the esketamine (K group) or non-eskatamine (C group) group." | 5.69 | Intraoperative intravenous low-dose esketamine improves quality of early recovery after laparoscopic radical resection of colorectal cancer: A prospective, randomized controlled trial. ( Ai, Y; He, L; Liu, S; Xu, Y; Zhang, C, 2023) |
| "The mini-dose esketamine-dexmedetomidine combination safely improved analgesia and subjective sleep quality after scoliosis correction surgery." | 5.69 | Mini-dose esketamine-dexmedetomidine combination to supplement analgesia for patients after scoliosis correction surgery: a double-blind randomised trial. ( Cui, F; Ma, JH; Wang, DX; Zhang, Y, 2023) |
| "The esketamine-based opioid-sparing anaesthetic protocol can shorten the postoperative first flatus time after benign laparoscopic surgery in gynaecology, and reduce the incidence of PONV." | 5.69 | Effects of intraoperative esketamine addition on gastrointestinal function after benign gynaecological laparoscopic surgery: a double-blind, randomized controlled study. ( Bao, S; Cao, X; Ma, W; Ma, Y; Ren, J; Zhang, L; Zhang, R, 2023) |
| "Subanaesthetic doses of esketamine can reduce postoperative pain in the PACU but delay the aesthetic recovery during the laparoscopic cholecystectomy, without affecting postoperative nausea and vomiting, and postoperative agitation." | 5.51 | Subanaesthetic dose of esketamine during induction delays anaesthesia recovery a randomized, double-blind clinical trial. ( Bao, F; He, J; Shi, Q; Xu, J; Zhang, C, 2022) |
| "This study aimed at examining the effect of a single sub-anesthetic dose of ketamine on postoperative fatigue syndrome (POFS) in patients undergoing radical laparoscopic surgery for colorectal cancer (CRC)." | 5.51 | Effect of a single sub-dose of ketamine on postoperative fatigue syndrome in colorectal cancer patients undergoing radical laparoscopic surgery: A double-blind, pilot study. ( Cheng, H; Zhang, H; Zhao, L, 2022) |
| "Adding dexmedetomidine to bupivacaine provides more effective postoperative pain control than adding ketamine during Pecs-II blocks for breast cancer surgery." | 5.51 | Comparing Effect of Adding Ketamine Versus Dexmedetomidine to Bupivacaine in Pecs-ⅠⅠ Block on Postoperative Pain Control in Patients Undergoing Breast Surgery. ( Eldeek, AM; Hefni, AF; Ismael, SA; Shaban, AR, 2022) |
| " S(+)-ketamine is an N-methyl-D-aspartic acid (NMDA) receptor antagonist with a strong analgesic effect and can significantly relieve postoperative acute pain and reduce opioid consumption." | 5.51 | Evaluation of the effect of perioperative administration of S(+)-ketamine hydrochloride injection for postoperative acute pain in children: study protocol for a prospective, multicenter, randomized, open-label, parallel-group, pragmatic clinical trial. ( Chen, P; Duan, C; Lan, C; Mi, W; Qu, S; Sun, Y; Wang, H; Yang, L; Zhang, J; Zhou, L, 2022) |
| "The Ketamine for Acute Pain Management After Trauma (KAPT) with registration # NCT04129086 was registered on October 16, 2019." | 5.51 | Ketamine for acute pain after trauma: the KAPT randomized controlled trial. ( Balogh, J; Green, C; Harvin, JA; Kao, LS; Klugh, J; Prater, SJ; Puzio, TJ; Sergot, PB; Stephens, CT; Wade, CE; Wandling, MW, 2022) |
| " The primary objective of this pilot study is to determine if multiple dosing over a three-day perioperative period with oral ketamine is a safe treatment method for acute pain after amputation surgery." | 5.48 | Oral Ketamine for Acute Pain Management After Amputation Surgery. ( Buvanendran, A; Kroin, JS; Moric, M; Rajagopal, A; Robison, SJ; Tuman, KJ, 2018) |
| "Intraoperative low-dose ketamine infusion did not improve the overall quality of recovery on POD 1 in patients undergoing breast cancer surgery." | 5.41 | The effect of low-dose ketamine on postoperative quality of recovery in patients undergoing breast cancer surgery: A randomised, placebo-controlled trial. ( Cao, J; Chen, Y; Han, Y; Liu, C; Xu, Q; Zhang, F; Zhao, Z, 2021) |
| "This study aims to investigate the effect of the pretreatment of S-ketamine on postoperative depression (POD) for breast cancer patients with mild/moderate depression." | 5.41 | Effect of Pretreatment of S-Ketamine On Postoperative Depression for Breast Cancer Patients. ( Li, P; Li, Q; Liu, C; Liu, P; Peng, S; Shi, X; Yan, H; Zhang, Y, 2021) |
| "The aim of this clinical trial was to test if intraoperative low-dose ketamine without postoperative infusion would reduce PPSP development after breast cancer surgery." | 5.34 | Effects of Intraoperative Low-Dose Ketamine on Persistent Postsurgical Pain after Breast Cancer Surgery: A Prospective, Randomized, Controlled, Double-Blind Study. ( Baik, JS; Cho, AR; Kang, C; Kim, C; Kim, E; Kim, H; Kim, KH; Kwon, JY; Lee, EA; Lee, HJ, 2020) |
| "BACKGROUND This study investigated the effects of various doses of S-ketamine on depression and pain management of cervical carcinoma patients with mild/moderate depression." | 5.34 | Use of Various Doses of S-Ketamine in Treatment of Depression and Pain in Cervical Carcinoma Patients with Mild/Moderate Depression After Laparoscopic Total Hysterectomy. ( Liu, P; Peng, S; Wang, J; Wang, Y; Xu, F; Xu, X, 2020) |
| "The aim of this study was to explore the overall reduction in the medication treatment cost of acute post-operative pain by adding intra-operative low-dose ketamine to traditional intravenous morphine for surgery in a low-income country." | 5.30 | Intra-operative low-dose ketamine does not reduce the cost of post-operative pain management after surgery: a randomized controlled trial in a low-income country. ( Alenyo-Ngabirano, A; Bodas, M; Caviglia, M; Della-Corte, F; Franc, JM; Kwizera, A; Ragazzoni, L; Ripoll-Gallardo, A; Ssemmanda, H, 2019) |
| " Adults without chronic pain and undergoing any elective cardiac surgery patients via sternotomy were randomly assigned to receive either usual care, pregabalin (150 mg preoperatively and twice daily for 14 postoperative days) alone, or pregabalin in combination with a 48-h postoperative infusion of intravenous ketamine at 0." | 5.30 | Prolonged Perioperative Use of Pregabalin and Ketamine to Prevent Persistent Pain after Cardiac Surgery. ( Anwar, S; Cooper, J; Langford, R; Rahman, J; Sharma, C, 2019) |
| "A single subanaesthetic dose of ketamine did not decrease delirium in older adults after major surgery, and might cause harm by inducing negative experiences." | 5.24 | Intraoperative ketamine for prevention of postoperative delirium or pain after major surgery in older adults: an international, multicentre, double-blind, randomised clinical trial. ( Abdallah, AB; Arya, VK; Avidan, MS; Downey, RJ; Emmert, DA; Fritz, BA; Grocott, HP; Hudetz, JA; Inouye, SK; Jacobsohn, E; Lee, YH; Mashour, GA; Maybrier, HR; Muench, MR; Noh, GJ; Pagel, PS; Pryor, KO; Rogers, EM; Veselis, RA; Vlisides, PE; Waberski, W; Waszynski, CM; Yulico, H, 2017) |
| "A total of 48 pediatric patients between 10 and 18 years diagnosed with idiopathic scoliosis were randomized to receive perioperative low-dose ketamine or placebo for 72 hours." | 5.24 | Prolonged Perioperative Low-Dose Ketamine Does Not Improve Short and Long-term Outcomes After Pediatric Idiopathic Scoliosis Surgery. ( Artés, D; Esteban, E; Ey Batlle, AM; Pascuets, C; Perelló, M, 2017) |
| " Compared with the control group, ketamine provided significant reduction of postoperative depression scale scores, by a standardized mean difference (SMD) of -0." | 5.22 | The effect of intravenous ketamine on depressive symptoms after surgery: A systematic review. ( Ai, P; An, D; Cui, V; Shi, H; Sun, Y; Wang, J; Wei, C; Wu, A, 2022) |
| "Primary outcomes were postoperative acute pain at rest/during movement after 24 h and number of patients with ketamine-related adverse events." | 5.22 | Perioperative ketamine for postoperative pain management in patients with preoperative opioid intake: A systematic review and meta-analysis. ( Kranke, P; Lipke, E; Meyer-Frießem, CH; Pogatzki-Zahn, EM; Reichl, S; Schnabel, A; Weibel, S; Zahn, PK, 2022) |
| " Here, we utilize fragility indices to assess the statistical robustness of RCTs evaluating low-dose ketamine during scoliosis surgery to reduce opioid tolerance and postoperative pain." | 5.22 | Statistical Fragility of Ketamine Infusion During Scoliosis Surgery to Reduce Opioid Tolerance and Postoperative Pain. ( Al Farii, H; Gupta, A; Mo, K; Movsik, J, 2022) |
| "In this meta-analysis, we aim to compare ketamine use versus a control group (saline solution) during induction of anesthesia in adolescent idiopathic scoliosis patients undergoing fusion surgery in terms of postoperative opioid consumption, pain control, and side effects." | 5.22 | Meta-analysis of the efficacy of ketamine in postoperative pain control in adolescent idiopathic scoliosis patients undergoing spinal fusion. ( Bas, JL; Bas, P; Bas, T; Bovea-Marco, M; Mariscal, G; Morales, J; Pérez, S; Rubio-Belmar, PA, 2022) |
| "Background and goal of study: there is evidence that perioperative intravenous ketamine and lidocaine reduce postoperative pain, postoperative opioids consumption, shortens hospital stay and accelerates intestinal function recovery." | 5.22 | Effect of a single dose of lidocaine and ketamine on intraoperative opioids requirements in patients undergoing elective gynecological laparotomies under general anesthesia. A randomized, placebo controlled pilot study. ( Egea-Guerrero, JJ; García-Navia, JT; Tornero López, J; Vázquez Gutiérrez, T; Vilches Arenas, A, 2016) |
| "The measurements were postoperative pain intensity during 24 hours; morphine consumption; time to first morphine supplementation; hyperalgesia (using monofilaments and an algometer) and allodynia (using a soft brush) in the thenar eminence of the nondominant hand and in the periumbilical region 24 hours after surgery; extent of hyperalgesia using a 300-g monofilament near the periumbilical region 24 hours after surgery; and serum levels of IL-6, IL-8, and IL-10." | 5.20 | Evaluation of the effect of ketamine on remifentanil-induced hyperalgesia: a double-blind, randomized study. ( Brunialti, MK; Leal, PC; Sakata, RK; Salomão, R, 2015) |
| "In this randomized controlled trial, we examined whether intra- and postoperative infusion of low-dose ketamine decreased postoperative morphine requirement and morphine-related adverse effects as nausea and vomiting after scoliosis surgery." | 5.20 | Intra- and postoperative low-dose ketamine for adolescent idiopathic scoliosis surgery: a randomized controlled trial. ( Hashiguchi, S; Ihara, N; Katori, N; Kosugi, S; Minoshima, R; Morisaki, H; Nishimura, D; Seki, H; Watanabe, K; Yamada, T, 2015) |
| "Adding epidural or IV racemic ketamine to TEA after thoracotomy did not lead to any reduction in PPP or allodynia." | 5.19 | Perioperative epidural or intravenous ketamine does not improve the effectiveness of thoracic epidural analgesia for acute and chronic pain after thoracotomy. ( Gomar, C; Rios, J; Tena, B, 2014) |
| "Ketamine and magnesium association reduces the post-operative morphine consumption after scoliosis surgery." | 5.19 | Ketamine and magnesium association reduces morphine consumption after scoliosis surgery: prospective randomised double-blind study. ( Abou Zeid, HA; Ghanem, IB; Jabbour, HJ; Jabbour, KB; Jawish, RJ; Naccache, NM; Rabbaa-Khabbaz, LG; Yazbeck, PH, 2014) |
| " A number of clinical trials provide evidence that the perioperative use of subanesthetic doses of ketamine reduces pain and opioid requirements in some surgical procedures, but the effect of prolonged perioperative low-dose ketamine infusion in patients undergoing posterior spinal fusion for pediatric scoliosis surgery is unknown." | 5.19 | Prolonged perioperative infusion of low-dose ketamine does not alter opioid use after pediatric scoliosis surgery. ( Cheng, Y; Finkel, JC; Junqueira, MM; Lovejoy, JF; Pestieau, SR; Quezado, Z; Wang, J, 2014) |
| "To evaluate the postoperative analgesia after surgical site infiltration with bupivacaine or ketamine in children undergoing cleft palate surgery." | 5.17 | A randomized study of surgical site infiltration with bupivacaine or ketamine for pain relief in children following cleft palate repair. ( Bhardwaj, N; Jha, AK; Mahajan, JK; Sharma, RK; Yaddanapudi, S, 2013) |
| "Dexmedetomidine and ketamine appear to prevent postoperative agitation and pain after sevoflurane anesthesia for pediatric strabismus surgery." | 5.17 | Comparison of the effects of dexmedetomidine, ketamine, and placebo on emergence agitation after strabismus surgery in children. ( Chen, JY; Jia, JE; Li, WX; Liu, TJ; Qin, MJ, 2013) |
| "These findings suggest that the routine use of a single dose of ketamine prior to chest wall incision is not effective at reducing pain or inflammation in thoracic surgery patients at 24 h postoperatively." | 5.15 | A randomized, double blind, placebo controlled clinical trial of the preoperative use of ketamine for reducing inflammation and pain after thoracic surgery. ( Bennett-Guerrero, E; D'Alonzo, RC; D'Amico, TA; Harpole, DH; Podgoreanu, M; Shaw, AD, 2011) |
| "We aimed to determine the hemodynamic effects and postoperative pain control quality of ropivacaine and ketamine addition to ropivacaine in children undergoing inguinal hernia repair with caudal anesthesia." | 5.14 | Effects of ketamine added to ropivacaine in pediatric caudal block. ( Demirci, M; Erhan, OL; Göksu, H; Odeş, R, 2010) |
| "Thirty-four adolescents aged 12-18 yr scheduled for scoliosis surgery were randomly assigned to receive intraoperative low-dose ketamine (bolus dose of 0." | 5.13 | Intraoperative low-dose ketamine does not prevent a remifentanil-induced increase in morphine requirement after pediatric scoliosis surgery. ( Crawford, MW; de Ruiter, J; Engelhardt, T; Howard, A; Naser, B; Pehora, C; Zaarour, C, 2008) |
| "We evaluated the use of continuous infusion of ketamine to reduce intraoperative remifentanil side effects, such as bradycardia and hypotension, and to improve postoperative analgesia from balanced anesthesia with remifentanil." | 5.13 | [Balanced anesthesia with continuous ketamine reduces adverse effects of remifentanil]. ( Onaka, M; Yamamoto, H, 2008) |
| " Midazolam with bupivacaine prolongs the duration of analgesia when administered intrathecally but does not prevent hypotension." | 5.13 | Combination of low doses of intrathecal ketamine and midazolam with bupivacaine improves postoperative analgesia in orthopaedic surgery. ( Batra, YK; Murali Krishna, T; Panda, NB; Rajeev, S, 2008) |
| "Fifty-six patients undergoing UAE embolization for treatment of symptomatic uterine leiomyomata were randomized to receive either 2 mg/ml of morphine (Control group, n=30) or 2 mg/ml of both morphine and ketamine (Ketamine group, n=26) by i." | 5.13 | No morphine sparing effect of ketamine added to morphine for patient-controlled intravenous analgesia after uterine artery embolization. ( Handberg, G; Helbo-Hansen, HS; Jensen, LL; Lohse, T; Lund, N; Munk, T; Skaarup, I, 2008) |
| "This study compared the effect of single-dose caudal epidural bupivacaine, bupivacaine plus ketamine and bupivacaine plus tramadol for postoperative pain management in children having surgery for inguinal hernia." | 5.13 | Comparison of caudal epidural bupivacaine with bupivacaine plus tramadol and bupivacaine plus ketamine for postoperative analgesia in children. ( Choudhuri, AH; Dharmani, P; Kumarl, N; Prakash, A, 2008) |
| "This study was designed to investigate whether the addition of tramadol or lidocaine to ketamine would enhance the quality of intra- and postoperative analgesia for hypospadias surgery in children." | 5.12 | Comparison of caudal ketamine with lidocaine or tramadol administration for postoperative analgesia of hypospadias surgery in children. ( Gunduz, M; Ozalevli, M; Ozbek, H; Ozcengiz, D, 2006) |
| "We tested the hypothesis that diprivan/ketamine (D/K) anesthesia would offer advantages compared to midazolam/ketamine (M/K) in patients undergoing minor gynecological surgery." | 5.12 | [Diprivan versus midazolam in combined anaesthesia with ketamin for minor gynecological surgery]. ( Partenov, P; Popov, I; Tablov, B; Tablov, V; Tsafarov, M, 2007) |
| "The results of the present study demonstrate that pre-emptive epidural ketamine is effective in reducing intra- and postoperative analgesic requirements, hyperalgesia and touch allodynia." | 5.11 | Effect of pre-emptive ketamine on sensory changes and postoperative pain after thoracotomy: comparison of epidural and intramuscular routes. ( Andersen, OK; Arendt-Nielsen, L; Camlica, H; Dereli, N; Ozyalcin, NS; Yucel, A, 2004) |
| "We hypothesized that perioperative ketamine administration would modify acute central sensitization following amputation and hence reduce the incidence and severity of persistent post-amputation pain (both phantom limb and stump pain)." | 5.11 | Perioperative intravenous ketamine infusion for the prevention of persistent post-amputation pain: a randomized, controlled trial. ( Armstrong-Brown, A; Burstal, R; Hayes, C, 2004) |
| "Forty-four children aged 1-5 years consecutively scheduled for inguinal hernia repair, hydrocele repair or orchidopexy were randomly assigned to receive a caudal injection of either S(+)-ketamine 1 mg x kg(-1) (group K) or S(+)-ketamine 0." | 5.11 | Caudal analgesia in children: S(+)-ketamine vs S(+)-ketamine plus clonidine. ( Almenrader, N; Canneti, A; Haiberger, R; Passariello, M; Pietropaoli, P; Rubeo, L, 2004) |
| " This study tested the hypotheses that increased pain sensitivity assessed by periincisional allodynia and hyperalgesia can occur after relatively large-dose intraoperative remifentanil and that small-dose ketamine prevents this hyperalgesia." | 5.11 | Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine. ( Chauvin, M; Fletcher, D; Guignard, B; Joly, V; Maurette, P; Richebe, P; Sessler, DI, 2005) |
| "Our aim was to compare the effect of single dose caudal ketamine, alfentanil or a mixture of both drugs in the treatment of pain after hypospadias repair surgery in children." | 5.10 | The comparison of caudal ketamine, alfentanil and ketamine plus alfentanil administration for postoperative analgesia in children. ( Akman, H; Bilen, A; Günes, Y; Ozalevli, M; Ozbek, H; Ozcengiz, D, 2002) |
| "After induction of general anesthesia, 42 patients, aged 1 to 7 yr, scheduled to undergo inguinal hernia repair randomly received a caudal (caudal group) or intramuscular (intramuscular group) injection of 1 mg/kg S(+)-ketamine." | 5.09 | Analgesic effects of caudal and intramuscular S(+)-ketamine in children. ( Erlacher, W; Klimscha, W; Koinig, H; Krenn, CG; Marhofer, P; Nikolic, A; Semsroth, M; Turnheim, K; Wildling, E, 2000) |
| "05 mg kg(-1) +droperidol 20 microg kg(-1) was given as prophylaxis for postoperative pain and emesis, respectively." | 5.08 | Desflurane versus propofol maintenance for outpatient laparoscopic cholecystectomy. ( Aasbø, V; Buanes, T; Grøgaard, B; Mjåland, O; Raeder, JC, 1998) |
| "The analgesic efficiency of ketamine and pethidine was compared in experimental ischemic pain and postoperative pain after oral surgery." | 5.06 | Comparison of ketamine and pethidine in experimental and postoperative pain. ( Hustveit, O; Maurset, A; Skoglund, LA; Øye, I, 1989) |
| " Ketamine was shown to increased postoperative nausea and vomiting." | 5.05 | Perioperative Analgesia for Patients Undergoing Thyroidectomy and Parathyroidectomy: An Evidence-Based Review. ( Lin, H; Nguyen, BK; Pashkova, AA; Pinto, J; Quan, D; Stathakios, J; Svider, PF, 2020) |
| "In study IV we hypothesized that intraoperative ketamine would reduce postoperative opioid consumption and persistent pain after spinal fusion surgery in chronic pain patients with opioid dependency." | 4.98 | Adjuvant analgesics for spine surgery. ( Nielsen, RV, 2018) |
| "To evaluate the efficacy and safety of perioperative intravenous ketamine in adult patients when used for the treatment or prevention of acute pain following general anaesthesia." | 4.98 | Perioperative intravenous ketamine for acute postoperative pain in adults. ( Bell, RF; Brinck, EC; Heesen, M; Kontinen, V; Moore, RA; Straube, S; Tiippana, E, 2018) |
| "In conclusion, these meta-analyses of nine trials confirm that ketamine and magnesium, differently but consistently, reduce hemodynamic variability during surgery and may be seen as complementary not only for pain control but also to provide stable anesthesia." | 4.95 | Stable anesthesia with alternative to opioids: Are ketamine and magnesium helpful in stabilizing hemodynamics during surgery? A systematic review and meta-analyses of randomized controlled trials. ( Cata, J; Forget, P, 2017) |
| "Peri-operative ketamine peritonsillar infiltration in children can reduce the incidence of postoperative nausea and vomiting (PONV), but its postoperative analgesic time is short." | 4.90 | Ketamine peritonsillar infiltration during tonsillectomy in pediatric patients: An updated meta-analysis. ( Chen, ZX; Ding, XB; Li, Q; Ren, H; Tong, Y; Wang, X, 2014) |
| "Ketamine, adverse effects, tachycardia, hypertension, postoperative pain, chronic postsurgical pain." | 4.31 | Effect of Analgesic Low-Dose Ketamine Infusions on the Cardiovascular Response: A Retrospective Analysis. ( Cadavid, AM; Calle, E; Camelo, JE; Casas, FD; Ramirez, CD; Tovar, A; Visbal, K, 2023) |
| "Opioid-free anesthesia (OFA) is associated with significantly reduced cumulative postoperative morphine consumption in comparison with opioid-based anesthesia (OBA)." | 4.12 | Opioid-free versus opioid-based anesthesia in pancreatic surgery. ( Closset, J; Forget, P; Galland, M; Hublet, S; Lafère, P; Loi, P; Navez, J, 2022) |
| " The acute pain group did not show an opioid reduction associated with the ketamine infusions." | 4.12 | Low-dose ketamine infusions reduce opioid use in pediatric and young adult oncology patients. ( Anghelescu, DL; Li, Y; Morgan, KJ; Patni, T; Ryan, S; Wu, D, 2022) |
| "Dexmedetomidine and ketamine may be administered intraoperatively as continuous infusions to provide opioid-sparing anesthesia." | 4.12 | Opioid-sparing anesthesia and patient-reported outcomes after open gynecologic surgery: a historical cohort study. ( Iniesta-Donate, M; Lasala, JD; Mena, GE; Meyer, L; Ramirez, PT; Wang, XS; Williams, LA; Zorrilla-Vaca, A, 2022) |
| "The present study evaluated the effects of ketamine in rats with the comorbidity of CPSP and depression." | 3.96 | Ketamine relieves depression-like behaviors induced by chronic postsurgical pain in rats through anti-inflammatory, anti-oxidant effects and regulating BDNF expression. ( Liu, Y; Ma, P; Ma, T; Song, Y; Yang, Y; Zhang, H; Zhang, X; Zhao, W; Zhao, Y, 2020) |
| " Anesthesia consisted of a single intramuscular injection of dexmedetomidine-ketamine-hydromorphone with intratesticular lidocaine and atipamezole and meloxicam postoperatively." | 3.85 | The influence of demeanor on scores from two validated feline pain assessment scales during the perioperative period. ( Buisman, M; Gunn, M; Hasiuk, MMM; Pang, DSJ, 2017) |
| "The objective of this systematic review is to examine the best available evidence on the clinical effectiveness of ketamine as an adjuvant to opioid-based therapy versus opioid-based therapy alone in decreasing perioperative pain associated with opioid tolerance in adult patients, aged 18-70 years, undergoing orthopedic surgical procedures." | 3.83 | Effectiveness of ketamine as an adjuvant to opioid-based therapy in decreasing pain associated with opioid tolerance in adults undergoing orthopedic surgery: a systematic review protocol. ( Bennett, M; Bonanno, L; Kuhn, W, 2016) |
| "04 mg/kg, subcutaneous) significantly enhanced mechanical allodynia and thermal hyperalgesia induced by the plantar incision during the postoperative period (each lasting between 2 h and 48 h), which was attenuated by pretreatment with ketamine (10 mg/kg, subcutaneous)." | 3.75 | Tyrosine phosphorylation of the N-Methyl-D-Aspartate receptor 2B subunit in spinal cord contributes to remifentanil-induced postoperative hyperalgesia: the preventive effect of ketamine. ( Cui, S; Gu, X; Liu, Y; Ma, Z; Wu, X, 2009) |
| "We evaluated the effect of ketamine-xylazine-acepromazine anesthesia (31." | 3.73 | Ketamine-xylazine-acepromazine anesthesia and postoperative recovery in rats. ( Huerkamp, MJ; Kinkead, B; Nemeroff, CB; Plotsky, PM; Thrivikraman, K; Welberg, LA, 2006) |
| " These address opioids for the management of breakthrough (episodic) pain in cancer patients, perioperative ketamine for acute postoperative pain, and superficial heat or cold for low back pain." | 3.73 | Evidence-based pain management and palliative care in Issue One for 2006 of The Cochrane Library. ( Wiffen, PJ, 2006) |
| "We examined the analgesic effect of racemic ketamine and its 2 enantiomers in 16 female patients (age: 20-29 years) suffering acute pain after oral surgery and in 7 female patients (age: 42-79 years) suffering chronic neuropathic orofacial pain." | 3.69 | Effect of ketamine, an NMDA receptor inhibitor, in acute and chronic orofacial pain. ( Mathisen, LC; Skjelbred, P; Skoglund, LA; Øye, I, 1995) |
| "This study was done to investigate the effectiveness and safety of ketamine analgesia after halothane anesthesia for surgery in children." | 3.67 | Postoperative ketamine analgesia in children: efficacy and safety after halothane anesthesia. ( Forestner, JE, 1988) |
| "Postoperative pain was assessed using the UNESP-Botucatu multidimensional feline pain assessment scale - short form." | 3.30 | Randomised, prospective, blinded, clinical trial of opioid-free injectable anaesthesia with or without multimodal analgesia in kittens undergoing ovariohysterectomy. ( Cheng, AJ; Garbin, M; Lutevele, N; Malo, A; Marangoni, S; Monteiro, BP; Ruel, HL; Steagall, PV; Watanabe, R, 2023) |
| "Ketamine treatment was associated with significantly lower NRS scores and morphine doses." | 3.30 | Perioperative use of ketamine infusion versus dexmedetomidine infusion for analgesia in obese patients undergoing bariatric surgery: a double-blinded three-armed randomized controlled trial. ( Ali, BEEH; El-Shaer, AN; Elderh, MSH; Khaja, MAR; Khalil, BNM; Taeimah, MOA, 2023) |
| "OFA also significantly reduced postoperative pain and morphine consumption (20 mg [1-21] vs." | 3.11 | Combined opioid free and loco-regional anaesthesia enhances the quality of recovery in sleeve gastrectomy done under ERAS protocol: a randomized controlled trial. ( Alnujaidi, OA; El Sanea, O; Elnabtity, AM; Hegab, A; Ibrahim, M, 2022) |
| "The postoperative pain was assessed postoperatively using the numeric rating scale at 0." | 3.11 | Effect of S-ketamine on Postoperative Quality of Recovery in Patients Undergoing Video-Assisted Thoracic Surgery. ( Cheng, X; Diao, M; Jiao, H; Wang, H, 2022) |
| "The secondary endpoints were postoperative pain intensity, postoperative complications, patient satisfaction assessed using the QoR-40 questionnaire and the financial cost of anesthesia." | 3.11 | The efficacy and safety of an adapted opioid-free anesthesia regimen versus conventional general anesthesia in gynecological surgery for low-resource settings: a randomized pilot study. ( Bengono Bengono, RS; Metogo, JM; Minkande, JZ; Ndikontar, R; Ngouatna, S; Ntock, FN; Tochie, JN, 2022) |
| " Secondary endpoints are postoperative NRS scores, the anaesthesia recovery time, time of first rescue analgesia, the incidence of rescue analgesia, the incidence of postoperative delirium, patient questionnaire for effect, changes from baseline in cognitive function and anxiety and depression, as well as the adverse events and pharmacoeconomic outcomes." | 3.01 | Perioperative intravenous S(+)-ketamine for acute postoperative pain in adults: study protocol for a multicentre, randomised, open-label, positive-controlled, pragmatic clinical trial (SAFE-SK-A trial). ( Chen, PY; Chu, HC; Diao, YG; Duan, CY; Hua, Z; Huang, WQ; Li, H; Liu, CM; Liu, YH; Meng, QT; Mi, WD; Wang, H; Wang, Q; Zhang, XY; Zhao, P; Zhou, LZ, 2021) |
| " Intraoperative ketamine is not associated with an increase in adverse events and may reduce postoperative nausea and vomiting (relative risk [RR] 0." | 3.01 | A Systematic Review of the Efficacy and Safety of Ketamine in Total Joint Arthroplasty. ( Casambre, FD; Della Valle, CJ; Fillingham, YA; Gililland, JM; Hamilton, WG; Hannon, CP; Nelson, N; Sporer, SM; Verity, TJ; Woznica, A, 2023) |
| " Secondary outcomes included postoperative visual analog scale (VAS) scores for pain and adverse effects associated with ketamine." | 3.01 | Efficacy and safety of perioperative application of ketamine on postoperative depression: A meta-analysis of randomized controlled studies. ( Gu, HW; Guo, J; Hashimoto, K; Qiu, D; Wang, XM; Yang, JJ; Zhang, GF, 2023) |
| "Tramadol was optimal in pain control, and dexamethasone also afforded good pain control with low incidences of nausea and vomiting." | 3.01 | The efficacy and safety of peri-tonsillar administrated agents on pain treatment after pediatric tonsillectomy: A network meta-analysis. ( Basurrah, MA; Hwang, SH; Kim, DH; Kim, SW, 2023) |
| "Chronic postsurgical pain is common after surgery." | 3.01 | Non-opioid analgesics for the prevention of chronic postsurgical pain: a systematic review and network meta-analysis. ( Cooper, NJ; Doleman, B; Lund, JN; Mathiesen, O; Sutton, AJ; Williams, JP, 2023) |
| "Chronic postsurgical pain (CPSP) has become a common complication during the perioperative period." | 3.01 | Effects of Ketamine on Chronic Postsurgical Pain in Patients Undergoing Surgery: A Systematic Review and Meta-analysis. ( Cui, Y; Fan, J; Fu, Y; Han, R; Sun, W; Wang, J; Wang, L; Wu, Y; Yu, Y; Zhou, Y, 2023) |
| "Ketamine continues to be a great tool in perioperative pain control, especially during an opioid epidemic." | 3.01 | Perioperative Use of Ketamine. ( Adegbola, A; Gritsenko, K; Medrano, EM, 2023) |
| "The incidence of postoperative nausea and vomiting, as well as psychotomimetic adverse effects post-abdominal surgery were similar between the 2 groups, respectively." | 3.01 | Effect of S-ketamine on Postoperative Pain in Adults Post-Abdominal Surgery: A Systematic Review and Meta-analysis. ( Deng, Y; Li, T; Liang, Y; Xie, M, 2023) |
| "Opioids are the cornerstone of postoperative pain management but their use can be limited by numerous side effects." | 3.01 | Analgesic Effect of Intraoperative Intravenous S-Ketamine in Opioid-Naïve Patients After Major Lumbar Fusion Surgery Is Temporary and Not Dose-Dependent: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. ( Brinck, ECV; Kankare, J; Kontinen, VK; Maisniemi, K; Tarkkila, P; Tielinen, L, 2021) |
| "Ketamine resulted in less postoperative pain than dexmedetomidine during the first 12 hours after third-molar surgery." | 3.01 | Comparison of Dexmedetomidine and Ketamine for Managing Postoperative Symptoms After Third-Molar Surgery. ( Gulsun, B; Gursoytrak, B; Kocaturk, Ö; Koparal, M, 2021) |
| "Ketamine is a potential analgesic alternative that may have advantages to narcotics in the bariatric population." | 3.01 | Ketamine infusion reduces narcotic requirements following gastric bypass surgery: a randomized controlled trial. ( Alex, G; Friedman, J; Mehta, SD; Sappenfield, JW; Smyth, D; Vasilopoulos, T, 2021) |
| "1 mg · kg-1 · h-1 for next 48 h [both medications dosed at ideal body weight]; methadone/ketamine group)." | 3.01 | Perioperative Methadone and Ketamine for Postoperative Pain Control in Spinal Surgical Patients: A Randomized, Double-blind, Placebo-controlled Trial. ( Avram, MJ; Benson, J; Bilimoria, S; Greenberg, SB; Maher, CE; Murphy, GS; Szokol, JW; Teister, K, 2021) |
| "Secondary outcome measures were postoperative pain scores, time to the first perception of pain, maternal adverse effects (nausea, vomiting, hypotension, shivering, diplopia, nystagmus, hallucination) and neonatal Apgar score at 1 and 5 min, neonatal respiratory depression and neonatal intensive-care referral." | 3.01 | Analgesic effects of intravenous ketamine after spinal anaesthesia for non-elective caesarean delivery: a randomised controlled trial. ( Adhikari, P; Pokharel, K; Sah, BP; Subedi, A, 2021) |
| "Ketamine has shown promise to have both opioid sparing and analgesic effects in the postoperative setting." | 2.94 | The efficacy of ketamine for postoperative pain control in adolescent patients undergoing spinal fusion surgery for idiopathic scoliosis. ( Afroze, F; Carl, A; Ehlers, M; Feustel, P; Leduc, L; Metcalfe, B; Pomerantz, M; Ricciardelli, RM; Silverman, E; Walters, NM, 2020) |
| "Morphine consumption was lower in group K2 compared to group K1 and group S at postoperative 30 min, and 1 and 2 h." | 2.94 | Effects of intraarticular ketamine combined with periarticular bupivacaine on postoperative pain after arthroscopic meniscectomy. ( Balkaya, AN; Demir, HF; Kocaoğlu, N; Köroğlu, A; Meriç, G; Sağır, Ö; Tatar, B; Ugün, F, 2020) |
| "Secondary outcome measures are postoperative pain intensity scores, psychological parameters, length of hospital stay and adverse events and will be reassessed at 3 and 6 months after surgery, with a baseline measurement preoperatively." | 2.90 | Assessing the effectiveness of perioperative s-ketamine on new-onset headache after resective epilepsy surgery (ESPAIN-trial): protocol for a randomised, double-blind, placebo-controlled trial. ( Bastiaenen, C; Bos, M; Colon, A; Dings, J; Hoogland, G; Rijkers, K; Rouhl, RPW; Schijns, OEMG; Sloekers, JCT; Theunissen, M; van Kuijk, S, 2019) |
| " The purpose of this study is to determine the efficacy of subanesthetic dosing of ketamine during TKA on postoperative pain and narcotic consumption." | 2.90 | Intraoperative Ketamine in Total Knee Arthroplasty Does Not Decrease Pain and Narcotic Consumption: A Prospective Randomized Controlled Trial. ( Emper, WD; Freedman, KB; Good, RP; Levicoff, EA; Longenecker, AS; McComb, JJ; Rhee, JH; Shaner, JL; Tan, TL, 2019) |
| "The primary outcome variable was postoperative pain intensity determined by a 10-point visual analog scale at 6-hour intervals over a period of 48 hours." | 2.90 | Does Sub-Anesthetic Ketamine Provide Postoperative Analgesia for Third Molar Surgery? ( Alashi, A; Brady, J; Cheung, J; Davis, B; Koto, P, 2019) |
| "Effective postoperative pain control reduces postoperative morbidity." | 2.87 | Effect of Intrathecally Administered Ketamine, Morphine, and Their Combination Added to Bupivacaine in Patients Undergoing Major Abdominal Cancer Surgery a Randomized, Double-Blind Study. ( Abd El-Rahman, AM; Mohamed, AA; Mohamed, SA; Mostafa, MAM, 2018) |
| "The mean (SD) overall postoperative pain scale score was higher in the control group than in the ketamine group [4." | 2.87 | Subcutaneous ketamine for postoperative pain relief in Rwanda: a randomized clinical trial. ( McKay, WP; Nyiligira, J; Sacevich, C; Semakuba, B; Thakore, S; Twagirumugabe, T, 2018) |
| "Mepivacaine horses were given mepivacaine 2% (3." | 2.87 | Local mepivacaine before castration of horses under medetomidine isoflurane balanced anaesthesia is effective to reduce perioperative nociception and cytokine release. ( Abass, M; Bettschart-Wolfensberger, R; Garzón, JFG; Kühnle, C; Picek, S; Zaghlou, A, 2018) |
| "Postoperative pain is a frequent cause for delayed discharge following outpatient procedures, including anorectal surgery." | 2.87 | Preemptive Analgesia Decreases Pain Following Anorectal Surgery: A Prospective, Randomized, Double-Blinded, Placebo-Controlled Trial. ( Callas, P; Cataldo, PA; Dominick, T; Jordan, MR; Leahy, DT; Moore, JS; Van Backer, JT, 2018) |
| "Objectives Cardiorespiratory parameters and anaesthesia quality in cats anaesthetised with either intramuscular (IM) alfaxalone or ketamine both combined with dexmedetomidine and butorphanol for castration were evaluated." | 2.84 | Comparison of intramuscular alfaxalone and ketamine combined with dexmedetomidine and butorphanol for castration in cats. ( Broussaud, S; Khenissi, L; Nikolayenkova-Topie, O; Touzot-Jourde, G, 2017) |
| " Further research is warranted to elucidate the optimal timing and dosing of IA ketamine and morphine for postoperative analgesic effects." | 2.82 | Effect of preemptive intra-articular morphine and ketamine on pain after arthroscopic rotator cuff repair: a prospective, double-blind, randomized controlled study. ( Amar, E; Chechik, O; Dolkart, O; Khashan, M; Maman, E; Mozes, G; Sharfman, Z; Weinbroum, A, 2016) |
| "Incidence of EA and postoperative pain scores were recorded at 10-min intervals in the postanaesthetic care unit (PACU)." | 2.82 | Comparison of effects of intravenous midazolam and ketamine on emergence agitation in children: Randomized controlled trial. ( Jung, JW; Kang, E; Kim, KM; Kim, YH; Ko, MJ; Lee, KH, 2016) |
| "Ketamine is an N-methyl D-aspartate antagonist that blocks transmission of painful stimuli and could be a useful medication for this patient population." | 2.82 | Low-Dose Ketamine Infusions for Highly Opioid-Tolerant Adults Following Spinal Surgery: A Retrospective Before-and-after Study. ( Green, T; King-Shier, K; Shinkaruk, K; Vaid, P, 2016) |
| " To reduce the risk for potential psychodysleptic side effects, however, ketamine dosing tends to be limited to low-dose regimens." | 2.82 | The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial. ( Bornemann-Cimenti, H; Edler, A; Michaeli, K; Sandner-Kiesling, A; Wejbora, M, 2016) |
| "PCA morphine consumption was less in group III (6." | 2.82 | Intrathecal Dexmedetomidine, Ketamine, and their Combination Added to Bupivacaine for Postoperative Analgesia in Major Abdominal Cancer Surgery. ( El-Rahman, AM; Fares, KM; Mohamed, SA, 2016) |
| "Ketamine is a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist that reduces acute postoperative pain." | 2.82 | Prospective, randomized, and controlled trial on ketamine infusion during bilateral axillo-breast approach (BABA) robotic or endoscopic thyroidectomy: Effects on postoperative pain and recovery profiles: A consort compliant article. ( Choi, JY; Hwang, JY; Jeon, YT; Kim, BG; Kim, DH; Oh, AY; Park, SJ; Ryu, JH, 2016) |
| "The incidence of postoperative pain was significantly less in the KETODEX group (15." | 2.80 | The effect of KETODEX on the incidence and severity of emergence agitation in children undergoing adenotonsillectomy using sevoflurane based-anesthesia. ( Daoud, A; Hadi, SM; Mei, X; Ouyang, W; Saleh, AJ; Tang, YZ, 2015) |
| "05), 24 h dosage of analgesia were significantly less (P < 0." | 2.80 | Preoperative and postoperative analgesic techniques in the treatment of patients undergoing transabdominal hysterectomy: a preliminary randomized trial. ( Chen, JQ; Hu, YM; Miao, JZ; Wen, LY; Wu, Z; Xue, R, 2015) |
| "Group K had significantly decreased postoperative pain scores at 1, 2, 6, and 12 h." | 2.80 | CLINICAL RESEARCH REGARDING PREEMPTIVE ANALGESIC EFFECT OF PREOPERATIVE KETAMINE AFTER TRANSURETHRAL RESECTION OF PROSTATE. ( Fu, Y; Ma, H; Wang, J; Wang, N, 2015) |
| "Ketamine is a phencyclidine derivative that induces a state of dissociative anesthesia." | 2.80 | A Comparative Study between the Effect of Combined Local Anesthetic and Low-dose Ketamine with Local Anesthetic on Postoperative Complications after Impacted Third Molar Surgery. ( Kale, TP; Kumar, A, 2015) |
| "The study also compared the incidence of postoperative nausea and vomiting, hallucinations, sedation, and respiratory depression in the 2 groups." | 2.79 | Effects of intra-operative ketamine administration on postoperative catheter-related bladder discomfort: a double-blind clinical trial. ( Etezadi, F; Khajavi, M; Lajevardi, M; Najafi, A; Shariat Moharari, G; Shariat Moharari, R, 2014) |
| "Ketamine and nefopam has been documented to decrease pain intensity and improve rehabilitation after total knee arthroplasty (TKA)." | 2.79 | Pain and recovery after total knee arthroplasty: a 12-month follow-up after a prospective randomized study evaluating Nefopam and Ketamine for early rehabilitation. ( Aveline, C; Bonnet, F; Cognet, F; Gautier, JF; Hetet, HL; Roux, AL; Vautier, P, 2014) |
| "Morphine use was further reduced in patients given both ketamine and pregabalin (38 (19) mg) with an interaction between ketamine and pregabalin (ANOVA factorial; p = 0." | 2.79 | The analgesic efficiency of combined pregabalin and ketamine for total hip arthroplasty: a randomised, double-blind, controlled study. ( Ben Ammar, S; Bouhassira, D; Chauvin, M; Cymerman, A; Fiaud, JF; Fletcher, D; Judet, T; Martinez, V; Mazoit, X; Poindessous, F; Rapon, C; Sessler, D, 2014) |
| "The following outcomes were evaluated: postoperative pain using the Numerical Rating Scale (NRS) and McGill Scale (SF_MPQ), mechanical pain thresholds using algometer application close to the wound, cortisol measurements, rescue analgesia, Spielberger State Trait Anxiety Inventory (STAI Y-6 item), patient satisfaction and opioid side effects." | 2.79 | Effect of perioperative electroacupuncture as an adjunctive therapy on postoperative analgesia with tramadol and ketamine in prostatectomy: a randomised sham-controlled single-blind trial. ( Dimitriadis, G; Kostoglou, C; Mavrommatis, C; Ntritsou, V; Tziris, N; Vasilakos, D; Zagka, P, 2014) |
| "Dogs with a postoperative pain score > 5 of 24 were given morphine as rescue analgesia." | 2.79 | Postoperative comparison of four perioperative analgesia protocols in dogs undergoing stifle joint surgery. ( Aarnes, TK; Bednarski, RM; Dyce, J; Hubbell, JA; Lewis, KA, 2014) |
| "Ketamine has anti-inflammatory, analgesic and antihyperalgesic effect and prevents pain associated with wind-up." | 2.79 | Does intravenous ketamine enhance analgesia after arthroscopic shoulder surgery with ultrasound guided single-injection interscalene block?: a randomized, prospective, double-blind trial. ( Baik, HJ; Chung, RK; Han, JI; Kim, YJ; Woo, JH, 2014) |
| " All data were recorded concerning the initial and total dosage of analgesic and the presence of complications within 24 hrs." | 2.78 | [A comparison of the effects of intraoperative tramadol and ketamine usage for postoperative pain relief in patients undergoing tonsillectomy]. ( Çelik, JB; Kara, I; Sizer, Ç; Topal, A, 2013) |
| "patient-controlled analgesia (IV-PCA) on postoperative nausea and vomiting (PONV) in patients at high risk of PONV undergoing lumbar spinal surgery." | 2.78 | Effect of ketamine as an adjunct to intravenous patient-controlled analgesia, in patients at high risk of postoperative nausea and vomiting undergoing lumbar spinal surgery. ( Kwak, YL; Park, SJ; Shim, JK; Song, JW; Song, Y; Yang, SY, 2013) |
| "Ketamine is an adjuvant demonstrating analgesic and opioid-sparing effects." | 2.78 | Ketamine decreases postoperative pain scores in patients taking opioids for chronic pain: results of a prospective, randomized, double-blind study. ( Barreveld, AM; Correll, DJ; Liu, X; Max, B; McGowan, JA; Nedeljkovic, SS; Shovel, L; Wasan, AD, 2013) |
| "Management of postoperative pain and emergence agitation following adenotonsillectomy in pediatrics has been a major challenge for anesthesiologists." | 2.78 | Ketamine improves postoperative pain and emergence agitation following adenotonsillectomy in children. A randomized clinical trial. ( Amin, A; Eghbal, MH; Sahmeddini, MA; Taregh, S, 2013) |
| "Ketamine is an analgesic suitable for the induction of anesthesia during Caesarean delivery." | 2.77 | Effect of three different doses of ketamine prior to general anaesthesia on postoperative pain following Caesarean delivery: a prospective randomized study. ( Aykaç, B; Bilgen, S; Fiçicioğlu, C; Köner, O; Menda, F; Türe, H, 2012) |
| " However, during cesarean section with neuraxial block, S-Ketamine might have adverse effects on the interaction between mothers and infants, including breastfeeding." | 2.77 | A study of low-dose S-ketamine infusion as "preventive" pain treatment for cesarean section with spinal anesthesia: benefits and side effects. ( Catarci, S; Draisci, G; Suppa, E; Valente, A; Zanfini, BA, 2012) |
| "Morphine was also administrated when the patients scored their pain above 4 on a visual analogue scale (VAS)." | 2.77 | Analgesic effects of ketamine infusion on postoperative pain after fusion and instrumentation of the lumbar spine: a prospective randomized clinical trial. ( Abrishamkar, S; Eshraghi, N; Feizi, A; Rafiei, A; Rahmani, P; Talakoub, R, 2012) |
| "Postoperative pain was assessed using a visual analogue scale and the time of first postoperative analgesic administration was noted." | 2.77 | Low-dose intravenous ketamine improves postoperative analgesia after caesarean delivery with spinal bupivacaine in African parturients. ( Desalu, I; Kushimo, OT; Menkiti, ID, 2012) |
| "Remifentanil requirements were higher in the MK group (P = 0." | 2.77 | The perioperative combination of methadone and ketamine reduces post-operative opioid usage compared with methadone alone. ( Carazo, J; Fernández Candil, J; Fernández Galinski, S; Moltó, L; Pacreu, S, 2012) |
| "Lidocaine was given as a bolus (1." | 2.77 | The effect of perioperative intravenous lidocaine and ketamine on recovery after abdominal hysterectomy. ( Grady, MV; Kurz, A; Mascha, E; Sessler, DI, 2012) |
| "Postoperative pain was scored on arrival to the PACU and at 30, 60, and 90 min thereafter." | 2.76 | Ketamine as an adjunct to fentanyl improves postoperative analgesia and hastens discharge in children following tonsillectomy - a prospective, double-blinded, randomized study. ( Chidambaran, V; Elshammaa, N; Housny, W; Michael, R; Thomas, J; Zhang, X, 2011) |
| "Ketamine induces a short-term effect on postoperative pain when administered intravenously immediately before or during acute pain." | 2.76 | Repeated and escalating preoperative subanesthetic doses of ketamine for postoperative pain control in patients undergoing tumor resection: a randomized, placebo-controlled, double-blind trial. ( Amar, E; Bickels, J; Chazan, S; Dadia, S; Ekstein, MP; Kollender, Y; Rakhman, E; Shmain, D; Weinbroum, AA; White, I, 2011) |
| "The incidence of postoperative pain and vomiting as well as the severity of postoperative pain were compared between study groups during the 6-hour postoperative period using a visual analog scale (VAS) at rest, upon swallowing saliva, drinking liquids and eating ice cream." | 2.76 | Intravenous and peritonsillar infiltration of ketamine for postoperative pain after adenotonsillectomy: a randomized placebo-controlled clinical trial. ( Dehghankhalili, M; Ghaffarpasand, F; Heiran, HR; Khademi, S; Motazedian, S; Yavari, MJ, 2011) |
| " The aim of this study was to evaluate the effect of oral ketamine on the dosage of local anesthetics required and postoperative pain management for irreversibly inflamed mandibular molars." | 2.76 | The effect of orally administered ketamine on requirement for anesthetics and postoperative pain in mandibular molar teeth with irreversible pulpitis. ( Ebtehaj, I; Kaviani, N; Khademi, A; Mohammadi, Z, 2011) |
| "Low dose of ketamine reduces postoperative pain and opioid consumption in adult studies." | 2.75 | Effects of perioperative intravenous low dose of ketamine on postoperative analgesia in children. ( Asehnoune, K; Bazin, V; Bollot, J; De Windt, A; Guillaud, C; Lejus, C; Nguyen, JM; Roquilly, A, 2010) |
| " We, therefore, investigated the analgesic effect of gabapentin, dexamethasone and low-dose ketamine in combination with paracetamol and ketorolac as compared with paracetamol and ketorolac alone after hip arthroplasty." | 2.75 | Multimodal analgesia with gabapentin, ketamine and dexamethasone in combination with paracetamol and ketorolac after hip arthroplasty: a preliminary study. ( Christensen, BV; Dahl, JB; Dierking, G; Hilsted, KL; Larsen, TK; Mathiesen, O; Rasmussen, ML, 2010) |
| "Ketamine is an N-methyl-d-aspartate receptor antagonist that has been shown to be useful in the reduction of acute postoperative pain and analgesic consumption in a variety of surgical interventions with variable routes of administration." | 2.75 | Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery. ( Abdu, WA; Beach, ML; Brown, JR; Clark, JA; Loftus, RW; Sengupta, DK; Yeager, MP, 2010) |
| "Ketamine was recently shown to attenuate postoperative pain when used in combination with morphine in patients who had undergone general and orthopedic surgery." | 2.75 | Low-dose ketamine via intravenous patient-controlled analgesia device after various transthoracic procedures improves analgesia and patient and family satisfaction. ( Buda, I; Chazan, S; Nesher, N; Paz, J; Weinbroum, AA, 2010) |
| "No drug affecting neuropathic pain (except opiates) was given during the follow-up." | 2.74 | Perioperative ketamine does not prevent chronic pain after thoracotomy. ( Dualé, C; Dubray, C; Filaire, M; Gimbert, YA; Guastella, V; Schoeffler, P; Sibaud, F; Taheri, H; Vallet, L, 2009) |
| "To evaluate the effects of patient-controlled analgesia (PCA) with small dose ketamine combined with morphine on analgesia and influence thereof on the plasma beta-endorphin (EP) level in the patients after radical operation for esophageal carcinoma." | 2.74 | [Effects of patient-controlled analgesia with small dose ketamine combined with morphine and the influence thereof on plasma beta-endorphin level in patients after radical operation for esophageal carcinoma]. ( Feng, J; Huang, XM; Li, H; Ma, LY; Wu, YQ; Xiong, JC; Xu, ZM; Zhang, DT, 2009) |
| " With 20 microgram/ml remifentanil in normal saline, postoperative PCA was administered with a background infusion at 2 ml/h following 2 ml as a loading dose and 1ml demand dose with a 3-minute lockout period." | 2.74 | Remifentanil combined with low-dose ketamine for postoperative analgesia of lower limb fracture: a double-blind, controlled study. ( Deng, GF; Tian, B; Wang, S; Zhang, SG; Zheng, JP, 2009) |
| "Ketamine has been shown to have a morphine-sparing effect soon after surgery." | 2.74 | The early and delayed analgesic effects of ketamine after total hip arthroplasty: a prospective, randomized, controlled, double-blind study. ( Baud, A; Couvret, C; Favard, L; Fusciardi, J; Laffon, M; Le Tendre, C; Pourrat, X; Remérand, F, 2009) |
| "No differences in postoperative pain scores were observed among groups." | 2.73 | Ketamine and lornoxicam for preventing a fentanyl-induced increase in postoperative morphine requirement. ( Hailan, W; Xia, J; Xuerong, Y; Yuguang, H, 2008) |
| "The fentanyl was used systematically during induction at the dosage of 5 microg/kg." | 2.73 | [Prevention of the acute tolerence with fentanyl by ketamine]. ( Diatta, B; Khalil, Y; Ndiaye, M; Ndoye Diop, M; Niang, B; Seck, M; Wade, A; Wade, KH, 2008) |
| "ketamine for postoperative pain relief in children after adenotonsillectomy, but none has investigated the efficacy of peritonsillar infiltration of ketamine in these children." | 2.73 | The efficacy of intravenous or peritonsillar infiltration of ketamine for postoperative pain relief in children following adenotonsillectomy. ( Aypar, U; Celebi, N; Celiker, V; Dal, D; Elvan, EG, 2007) |
| "Hallucinations were more common in ketamine patients, but other side effects were similar." | 2.73 | The addition of a small-dose ketamine infusion to tramadol for postoperative analgesia: a double-blinded, placebo-controlled, randomized trial after abdominal surgery. ( Burn, SJ; Crofts, T; Kolawole, H; Leong, S; Skinner, BS; Taverner, M; Webb, AR, 2007) |
| "Small-dose ketamine did not decrease postoperative pain after tonsillectomy in children when added to a continuous intraoperative remifentanil infusion." | 2.73 | Intraoperative small-dose ketamine does not reduce pain or analgesic consumption during perioperative opioid analgesia in children after tonsillectomy. ( Al-Khasti, MJ; Al-Qattan, AR; Batra, YK; Belani, KG; Rawdhan, HJ; Shamsah, M, 2007) |
| "In some patients, control of postoperative pain can be difficult with morphine alone." | 2.73 | The use of ketamine as rescue analgesia in the recovery room following morphine administration--a double-blind randomised controlled trial in postoperative patients. ( Angliss, M; Gillies, A; Lindholm, D; Orr, A, 2007) |
| "Morphine consumption was evaluated by cumulative doses every 12 h for the three postoperative days." | 2.73 | Adding ketamine to morphine for patient-controlled analgesia after thoracic surgery: influence on morphine consumption, respiratory function, and nocturnal desaturation. ( Avaro, JP; Blayac, D; Dantin, T; Gaillat, F; Guervilly, C; Hélaine, A; Kerbaul, F; Michelet, P; Thomas, P, 2007) |
| "before the incision." | 2.73 | Comparison of a preincisional and postincisional small dose of ketamine for postoperative analgesia in children. ( Butkovic, D; Jakobovic, J; Kralik, S; Matolic, M; Radesic, L; Zganjer, M, 2007) |
| "as placebo." | 2.73 | [Intra-articular ketamine after arthroscopic knee surgery. Optimisation of postoperative analgesia]. ( Borner, M; Bürkle, H; Horoshun, G; Riewendt, HD; Trojan, S; Wappler, F, 2007) |
| "No patient had hallucinations." | 2.73 | Subanaesthetic ketamine spares postoperative morphine and controls pain better than standard morphine does alone in orthopaedic-oncological patients. ( Bickels, J; Chazan, S; Kollender, Y; Maruoani, N; Meller, I; Nirkin, A; Stocki, D; Weinbroum, AA, 2008) |
| "Ketamine decreases postoperative morphine consumption, but its optimal dosing and duration of administration remain unclear." | 2.73 | Postoperative ketamine administration decreases morphine consumption in major abdominal surgery: a prospective, randomized, double-blind, controlled study. ( Beloucif, S; Dupont, H; Lorne, E; Montravers, P; Moubarak, M; Samarcq, D; Zakine, J, 2008) |
| "Ketamine is an effective and safe multimodal analgesic in patients undergoing breast surgery, administered both intravenously and when added to bupivacaine in paravertebral blocks." | 2.72 | The Effect of Ketamine on Acute and Chronic Wound Pain in Patients Undergoing Breast Surgery: A Meta-Analysis and Systematic Review. ( Bi, Y; Liu, B; Ma, J; Ye, Y; Zhang, X; Zhu, Y, 2021) |
| " In addition, ketamine seems to be most successful when administered consistently throughout a procedure, such as by an infusion instead of a single bolus, in order to have adequate dosing for an analgesic effect." | 2.72 | Ketamine Use in the Surgical Patient: a Literature Review. ( Moon, TS; Smith, KM, 2021) |
| "Tramadol may be better to alleviate the postoperative pain after pediatric adenotonsillectomy or tonsillectomy." | 2.72 | The comparison of ketamine with tramadol for postoperative pain relief on children following adenotonsillectomy or tonsillectomy: A meta-analysis of randomized controlled trials. ( Guo, Y; Tian, J; Wang, L, 2021) |
| "Morphine consumption was assessed during 24 H, and pain scores were measured using a visual analogue scale (VAS) at rest and on mobilisation, during the first two postoperative days." | 2.72 | Peroperative ketamine and morphine for postoperative pain control after lumbar disk surgery. ( Aveline, C; Bonnet, F; Gautier, JF; Hetet, HL; Vautier, P, 2006) |
| "To evaluate the preemptive effects of diclofenac sodium, in combination with remifentanil and ketamine." | 2.72 | The preemptive use of diclofenac sodium in combination with ketamine and remifentanil does not enhance postoperative analgesia after laparoscopic gynecological procedures. ( Aypar, U; Canbay, O; Celebi, N; Coskun, F; Karakas, O; Peker, L, 2006) |
| "Postoperative pain was scored by the Oucher scale." | 2.72 | Effect of an intravenous single dose of ketamine on postoperative pain in tonsillectomy patients. ( Bruggemann DA Conceição, D; Carneiro Leão, C; DA Conceição, MJ, 2006) |
| "To investigate the clinical efficacy of and complications arising from low-dose ketamine combined with fentanyl for intravenous postoperative analgesia in comparison with the exclusive use of fentanyl in elderly patients." | 2.72 | [Low-dose ketamine combined with fentanyl for intravenous postoperative analgesia in elderly patients]. ( Chen, YM; Liang, SW; Lin, CS, 2006) |
| "To assess postoperative pain regulation and pharmacokinetic effects of preoperative administration of ketamine and midazolam." | 2.72 | Improved postoperative analgesia with coadministration of preoperative epidural ketamine and midazolam. ( Wang, G; Wang, X; Xie, H, 2006) |
| "Ketamine is a potent analgesic agent in addition to its anesthetic properties." | 2.72 | Effect of oral ketamine on the postoperative pain and analgesic requirement following orthopedic surgery. ( Hashemi, SJ; Heidari, SM; Parvazinia, P; Saghaei, M, 2006) |
| "Ketamine has been shown to prolong analgesia produced by caudal local anaesthetic block and is now in common use." | 2.71 | A comparison between local anaesthetic dorsal nerve block and caudal bupivacaine with ketamine for paediatric circumcision. ( Gauntlett, I, 2003) |
| "Postoperative pain was assessed by means of an observational 10-point scoring system and analgesia was administered if the pain score exceeded a value of 3." | 2.71 | Caudal bupivacaine and s(+)-ketamine for postoperative analgesia in children. ( Weber, F; Wulf, H, 2003) |
| "Ketamine has an opioid sparing effect following surgery in adults." | 2.71 | Double-blind randomized placebo-controlled trial of the effect of ketamine on postoperative morphine consumption in children following appendicectomy. ( Dix, P; Martindale, S; Stoddart, PA, 2003) |
| "Ketamine was administered with an initial bolus of 0." | 2.71 | The effects of small-dose ketamine on morphine consumption in surgical intensive care unit patients after major abdominal surgery. ( Branger, B; Campion, JP; Guillou, N; Mallédant, Y; Seguin, P; Tanguy, M, 2003) |
| "The ketamine group was administered a ketamine bolus and infusion during surgery." | 2.71 | Intraoperative intravenous ketamine in combination with epidural analgesia: postoperative analgesia after renal surgery. ( Karaman, H; Kararmaz, A; Kaya, S; Ozyilmaz, MA; Turhanoglu, S, 2003) |
| "Postoperative pain was treated by fentanyl IV and oxycodone 5 mg/acetaminophen 325 mg PO as required for pain." | 2.71 | Preincisional treatment to prevent pain after ambulatory hernia surgery. ( Horvath, KD; Pavlin, DJ; Pavlin, EG; Sima, K, 2003) |
| "Our basic finding was reduction in postoperative pain and consumption of adequate analgesic drugs with intra-articular ketamine, bupivacaine, or neostigmine use." | 2.71 | The efficacy of intra-articular ketamine for postoperative analgesia in outpatient arthroscopic surgery. ( Altunkaya, H; Dal, D; Doral, MN; Tetik, O, 2004) |
| "S(+)-ketamine is a new drug formulation that contains the more potent S(+)-stereoisomer of ketamine." | 2.71 | Improvement of pain treatment after major abdominal surgery by intravenous S+-ketamine. ( Argiriadou, H; Georgiou, M; Giala, M; Himmelseher, S; Kanakoudis, F; Kochs, E; Papagiannopoulou, P, 2004) |
| "Tramadol was used for postoperative analgesia." | 2.71 | Oral ketamine premedication can prevent emergence agitation in children after desflurane anaesthesia. ( Kararmaz, A; Kaya, S; Ozyilmaz, MA; Turhanoglu, S, 2004) |
| "Morphine titration was successful in all ketamine and nefopam patients but failed in four control patients (two because of respiratory toxicity and two because of persistent pain)." | 2.71 | Nefopam and ketamine comparably enhance postoperative analgesia. ( Alfonsi, P; Chauvin, M; Guignard, B; Kapfer, B; Sessler, DI, 2005) |
| "To evaluate the analgesic and adverse effects of epidurally administered levogyral (S[+]) ketamine alone or in combination with morphine on intraoperative and postoperative pain in dogs undergoing ovariohysterectomy." | 2.71 | Analgesic effects of epidurally administered levogyral ketamine alone or in combination with morphine on intraoperative and postoperative pain in dogs undergoing ovariohysterectomy. ( Acosta, AD; Bopp, S; Correa-Natalini, C; Gomar, C; Polydoro, A; Sala-Blanch, X, 2005) |
| "Treatment with ketamine and pethidine is effective in postoperative shivering." | 2.71 | Efficacy of prophylactic ketamine in preventing postoperative shivering. ( Akinci, SB; Aypar, U; Basgul, E; Dal, D; Honca, M; Kose, A, 2005) |
| "Monitoring for pain, sedation, postoperative nausea/vomiting, dizziness, and pruritus was performed by anesthesiologists blinded to the study allocation." | 2.71 | Caudal additives in pediatrics: a comparison among midazolam, ketamine, and neostigmine coadministered with bupivacaine. ( Acharya, A; Kumar, P; Pan, AK; Rudra, A, 2005) |
| "Ketamine has been claimed to prevent acute opioid tolerance and hyperalgesia following acute exposure to opioids and its use has been proposed to decrease postoperative morphine consumption." | 2.71 | Low-dose ketamine failed to spare morphine after a remifentanil-based anaesthesia for ear, nose and throat surgery. ( Abisseror, M; Chambost, V; Charpiat, B; Ganne, C; Ganne, O; Malhière, S; Menault, P; Viale, JP, 2005) |
| "Although postoperative pain measurements did not differ, postoperative epidural treatment (intravenous-epidural) was less effective to prevent residual pain at 1 yr (11%; P = 0." | 2.71 | Intraoperative epidural analgesia combined with ketamine provides effective preventive analgesia in patients undergoing major digestive surgery. ( De Kock, M; Lavand'homme, P; Waterloos, H, 2005) |
| "Morphine consumption was lower in groups 2 and 3 at 0 to 2 hours (P < ." | 2.71 | The influence of timing of systemic ketamine administration on postoperative morphine consumption. ( Alev, T; Bilgin, H; Bilgin, T; Kerimoğlu, B; Osma, S; Ozcan, B; Toker, A; Uçkunkaya, N, 2005) |
| "Ketamine can enhance anesthetic and analgesic actions of a local anesthetic via a peripheral mechanism." | 2.70 | No enhancement of sensory and motor blockade by ketamine added to ropivacaine interscalene brachial plexus blockade. ( Choi, YS; Kim, NS; Kim, WK; Kong, MH; Lee, IO; Lee, MK; Lim, SH, 2002) |
| "To compare indicators of postoperative pain and behavior in dogs with and without a low-dose ketamine infusion added to usual perioperative management." | 2.70 | Use of low doses of ketamine administered by constant rate infusion as an adjunct for postoperative analgesia in dogs. ( Gaynor, JS; Hellyer, PW; Mama, KR; Wagner, AE; Walton, JA, 2002) |
| "Opioids contribute to postoperative nausea and vomiting (PONV)." | 2.70 | [Recovery from anaesthesia and incidence and intensity of postoperative nausea and vomiting following a total intravenous anaesthesia (TIVA) with S-(+)-ketamine/propofol compared to alfentanil/propofol]. ( Hering, W; Kessebohm, K; Kundt, HJ; Schmid, M; St Pierre, M, 2002) |
| "Ketamine is a safe and effective alternative to morphine to provide analgesia in the immediate postoperative period after tonsillectomy." | 2.70 | A prospective randomized controlled study of the efficacy of ketamine for postoperative pain relief in children after adenotonsillectomy. ( Aspinall, RL; Mayor, A, 2001) |
| "Wound mechanical hyperalgesia was evaluated and residual pain was assessed by asking the patients at 2 weeks, and 1, 6, and 12 months." | 2.70 | 'Balanced analgesia' in the perioperative period: is there a place for ketamine? ( De Kock, M; Lavand'homme, P; Waterloos, H, 2001) |
| "Postoperative pain was rated at 0, 3, 6, 12, 24, and 48 h postoperatively by visual analogue scale scores (VAS)." | 2.70 | Preincisional intravenous low-dose ketamine and local infiltration with ropivacaine reduces postoperative pain after laparoscopic cholecystectomy. ( Argiriadou, H; Georgiou, M; Papagiannopoulou, P; Papaziogas, B; Papaziogas, T; Pavlidis, T; Sfyra, E, 2001) |
| "Patients were randomly allocated to one of the two treatment groups: patients in Group 1 received epidural morphine 50 microg/kg whereas patients in Group 2 received epidural ketamine 1 mg/kg combined with 50 microg/kg of morphine postoperatively." | 2.70 | Evaluation of the safety and efficacy of epidural ketamine combined with morphine for postoperative analgesia after major upper abdominal surgery. ( Kumar, L; Pawar, DK; Subramaniam, B; Subramaniam, K, 2001) |
| " These patients were randomly allocated to one of the two treatment groups: patients in Group 1 received epidural morphine 50 microg/kg, whereas those in Group 2 received epidural ketamine 1 mg/kg combined with 50 microg/kg of morphine 30 min before incision." | 2.70 | Preoperative epidural ketamine in combination with morphine does not have a clinically relevant intra- and postoperative opioid-sparing effect. ( Pawar, DK; Sennaraj, B; Subramaniam, B; Subramaniam, K, 2001) |
| "S(+)-ketamine has a higher affinity for the N-methyl-D-aspartate receptor and less-serious side effects than racemic ketamine." | 2.70 | Perioperative small-dose S(+)-ketamine has no incremental beneficial effects on postoperative pain when standard-practice opioid infusions are used. ( Dann, K; Fitzal, S; Jaksch, W; Lang, S; Raab, G; Reichhalter, R, 2002) |
| " This study concludes that the addition of ketamine to morphine, in this dosage regimen, administered via PCAS for postoperative pain control, does not confer benefit following total abdominal hysterectomy." | 2.70 | Effect of the addition of ketamine to morphine in patient-controlled analgesia. ( Crooks, BA; Miller, CD; Murdoch, CJ, 2002) |
| "Ketamine 60 mg was injected epidurally through an indwelling catheter that was inserted at the T7-8 or T8-9 interspace in 98 patients." | 2.69 | Preoperative epidural ketamine does not have a postoperative opioid sparing effect. ( Kizilkaya, M; Kucuk, N; Tokdemir, M, 1998) |
| "(R)-ketamine was used due to the lower incidence of side-effects." | 2.69 | Lack of pre-emptive analgesic effect of (R)-ketamine in laparoscopic cholecystectomy. ( Aasbø, V; Mathisen, LC; Raeder, J, 1999) |
| "We compared postoperative pain in two groups." | 2.69 | [Continuous total intravenous anesthesia is useful for postoperative pain management]. ( Akatsuka, M; Doi, Y; Hashimoto, M; Mori, H; Onaka, M; Yamamoto, H, 1999) |
| " combined with epidural bupivacaine at 0-24 h, or epidural morphine at 24-48 h after renal surgery." | 2.69 | Effect of i.v. ketamine in combination with epidural bupivacaine or epidural morphine on postoperative pain and wound tenderness after renal surgery. ( Brennum, J; Dahl, JB; Hansen, TM; Ilkjaer, S; Nikolajsen, L; Wernberg, M, 1998) |
| "morphine was used for postoperative analgesia." | 2.69 | Preoperative small-dose ketamine has no preemptive analgesic effect in patients undergoing total mastectomy. ( Adam, F; Beal, J; Lefebvre, D; Libier, M; Meynadier, J; Oszustowicz, T, 1999) |
| "Postoperative pain was controlled by epidural infusion of the mixture of fentanyl (25 mcg." | 2.69 | [Pre-incisional administration of ketamine reduced the postoperative pain]. ( Hazama, K; Kawaguchi, R; Nakagawa, M; Nakao, M; Nakatani, K; Unetani, H, 1999) |
| "Pre-incisional epidural K+M+B treatment combined with continuous epidural anaesthesia and general anaesthesia provides an ideal pre-emptive analgesic therapy, exhibiting better postoperative pain relief than general anaesthesia and post-incisional K+M+B treatment." | 2.69 | Pre-incisional epidural ketamine, morphine and bupivacaine combined with epidural and general anaesthesia provides pre-emptive analgesia for upper abdominal surgery. ( Ho, ST; Lee, MM; Tao, PL; Wong, CS; Wu, CT; Yeh, CC; Yu, JC, 2000) |
| "Postoperative pain was assessed by means of a modified Objective Pain Score and analgesia was administered if this score exceeded four." | 2.69 | The effect of ketamine on 0.25% and 0.125% bupivacaine for caudal epidural blockade in children. ( Aldridge, LM; Doyle, E; Findlow, D; Johnston, P, 1999) |
| "Ketamine may produce "preemptive" analgesia when administered before surgically induced trauma." | 2.69 | Does ketamine have preemptive effects in women undergoing abdominal hysterectomy procedures? ( Dahl, V; Ernoe, PE; Raeder, JC; Steen, T; White, PF, 2000) |
| "Postoperative pain was assessed using a modified 10-cm visual analogue scale and analgesia was administered if the pain score exceeded a value of 3." | 2.69 | Caudal ropivacaine and ketamine for postoperative analgesia in children. ( Lee, HM; Sanders, GM, 2000) |
| "Postoperative pain was assessed using a modified objective pain score and analgesia was administered if this score exceeded 4." | 2.68 | Comparison of the effects of adrenaline, clonidine and ketamine on the duration of caudal analgesia produced by bupivacaine in children. ( Aldridge, LA; Cook, B; Doyle, E; Grubb, DJ, 1995) |
| "IVPCA ketamine in combination with morphine provides superior postsurgical pain relief at lower dosage and with fewer side effects than morphine alone." | 2.68 | Comparison of morphine and morphine with ketamine for postoperative analgesia. ( Colclough, GW; Javery, KB; Steger, HG; Ussery, TW, 1996) |
| "Postoperative pain was assessed by means of a modified Objective Pain Score and analgesia was administered if this score exceeded four." | 2.68 | The optimal dose of ketamine for caudal epidural blockade in children. ( Aldridge, LM; Doyle, E; Findlow, D; Semple, D, 1996) |
| "Postoperative pain was assessed by measuring morphine consumption and visual analog scale (0-100 mm) pain scores at rest." | 2.68 | Preemptive ketamine decreases postoperative narcotic requirements in patients undergoing abdominal surgery. ( Fu, ES; Miguel, R; Scharf, JE, 1997) |
| "Using punctuate mechanical hyperalgesia as a measure of central sensitization, we examined whether induction and maintenance of central sensitization after surgery could be prevented by a low-dose infusion of the NMDA-receptor antagonist ketamine." | 2.68 | Mapping of punctuate hyperalgesia around a surgical incision demonstrates that ketamine is a powerful suppressor of central sensitization to pain following surgery. ( Breivik, H; Eide, PK; Foss, A; Kreunen, M; Stubhaug, A, 1997) |
| "Postoperative pain was assessed by means of a modified Objective Pain Score and analgesia was administered if this exceeded a value of 4." | 2.68 | Comparison of caudal block using bupivacaine and ketamine with ilioinguinal nerve block for orchidopexy in children. ( Aldridge, LM; Doyle, E; Findlow, D, 1997) |
| "In a randomized, double-blind study, postoperative pain was assessed in 22 patients undergoing elective open cholecystectomy with two types of anesthesia: standardized general anesthesia (control group), and low-dose ketamine as an addition to the same method of general anesthesia, before surgical incision (ketamine group)." | 2.67 | Postoperative pain: the effect of low-dose ketamine in addition to general anesthesia. ( Fisher, A; Glazer, M; Greemberg, L; Katz, J; Korotkoruchko, A; Roytblat, L, 1993) |
| "The surgical wound hyperalgesia was assessed by measuring pain threshold to pressure on the wound by using an algometer, and also by measuring the intensity of pain to suprathreshold pressure on the wound with the visual analog self-rating method." | 2.67 | Preemptive effect of fentanyl and ketamine on postoperative pain and wound hyperalgesia. ( Bradley, EL; Finger, J; Isakson, A; Kissin, I; Oz, Y; Tverskoy, M, 1994) |
| "Surgery for pectus excavatum is associated with significant postoperative pain." | 2.66 | Postoperative pain control following minimally invasive correction of pectus excavatum in pediatric patients: A systematic review. ( Archer, V; Fitzgerald, P; Kattail, D; Robinson, T; Walton, JM, 2020) |
| " Dosage of ketamine varied widely from 0." | 2.66 | A Systematic Review of Intra-Articular Ketamine for Postoperative Analgesia. ( Covington, SM; D'Souza, RS; Erwin, PJ; Qu, W, 2020) |
| "Postoperative pain was graded as strong, medium, mild, and painfree state." | 2.66 | [Anesthesia in patients with varicose syndrome]. ( Kujundzić, D; Zanić-Matanić, D, 1989) |
| "The prevention of postoperative pain in children who had undergone tonsillectomy was investigated in a double-blind trial." | 2.66 | Prevention of post-tonsillectomy pain with analgesic doses of ketamine. ( Bester, HF; le Roux, M; Murray, WB; Yankelowitz, SM, 1987) |
| " Group I pentazocine: Mean dosage on the day of operation 0." | 2.65 | [Clinical experimental studies of postoperative infusion analgesia]. ( Dick, W; Grundlach, G; Klein, I; Knoche, E, 1983) |
| " Mean dosage was 0." | 2.65 | Clinical experimental studies of postoperative infusion analgesia. ( Bowdler, I; Dick, W; Gundlach, G; Knoche, E, 1983) |
| " With regard to the dosage and method of administration, ketamine was shown to be less effective than morphine for the first 3 hours postoperatively, but equally effective subsequently, whereas the patients who received ketamine showed a greater progressive tendency for their respiratory parameters to improve with time." | 2.64 | Intravenous ketamine for postoperative analgesia. ( Clausen, L; Sinclair, DM; Van Hasselt, CH, 1975) |
| "However, LAK had no effect on trismus reduction after third molar surgery." | 2.61 | Local Ketamine Improves Postoperative Analgesia After Third Molar Surgery. ( Ascencio-Padilla, R; Chavarria-Bolaños, D; Esparza-Villalpando, V; Hidalgo-Hurtado, JA; Pozos-Guillen, A; Pozos-Guillen, F, 2019) |
| "Ketamine was associated with a significant reduction of cumulative morphine consumption." | 2.61 | Ketamine reduces pain and opioid consumption after total knee arthroplasty: A meta-analysis of randomized controlled studies. ( Chen, Y; Li, Z, 2019) |
| "Data (ie, pain intensity, morphine consumption, gastrointestinal and psychotic adverse effects) were extracted by two reviewers independently." | 2.61 | Analgesic efficacy and safety of ketamine after total knee or hip arthroplasty: a meta-analysis of randomised placebo-controlled studies. ( Ding, X; He, H; Lei, G; Li, J; Wang, Y; Wei, J; Wu, Z; Xie, D; Xu, B; Zeng, C, 2019) |
| "The incidence of emergence agitation was 14." | 2.61 | The effect of ketamine on emergence agitation in children: A systematic review and meta-analysis. ( Lai, YS; Ng, KT; Sarode, D; Teoh, WY; Wang, CY, 2019) |
| " Future studies and best practice techniques can facilitate standardization of regional anesthesia adjuvant dosing when providing nerve blocks in clinical practice." | 2.61 | Adjuvants in clinical regional anesthesia practice: A comprehensive review. ( Cornett, EM; Gaignard, SM; Kaye, AD; Kaye, RJ; Lambert, T; Moll, V; Prabhakar, A; Ragusa, J; Urman, RD; Wheat, S, 2019) |
| "Ketamine is a phencyclidine intravenous anaesthetic that blocks N-methyl-d-aspartate receptors and HCN channels in the CNS." | 2.61 | Low-dose ketamine in painful orthopaedic surgery: a systematic review and meta-analysis. ( Onakpoya, IJ; Riddell, JM; Trummel, JM, 2019) |
| "The ketamine group also reported lower postoperative pain scores at 6, 12, and 24 hours (all Ps < 0." | 2.58 | Perioperative Ketamine for Analgesia in Spine Surgery: A Meta-analysis of Randomized Controlled Trials. ( Bederman, SS; Eichler, M; Farhan, SD; Field, R; Pendi, A, 2018) |
| " In addition, there were fewer adverse effects in the ketamine groups." | 2.58 | Efficiency and safety of ketamine for pain relief after laparoscopic cholecystectomy: A meta-analysis from randomized controlled trials. ( Chang, L; Chen, P; Xie, H; Zhang, L; Zhu, J, 2018) |
| "Chronic postsurgical pain (CPSP) is an important and well recognized cause of much long-term suffering, which in some cases may be preventable and affects many people living with cancer." | 2.58 | Chronic postsurgical pain and cancer: the catch of surviving the unsurvivable. ( Bhaskar, A; Humble, SR; Jayaweera, A; Varela, N, 2018) |
| "The experience of intense postoperative pain remains a significant problem in perioperative medicine." | 2.55 | Clinical application of perioperative multimodal analgesia. ( Bruhn, J; Scheffer, GJ; van Geffen, GJ, 2017) |
| "Of all the postsurgical pain conditions, thoracotomy pain poses a particular therapeutic challenge in terms of its prevalence, severity, and ensuing postoperative morbidity." | 2.55 | Perioperative Ketamine Administration for Thoracotomy Pain. ( Diaz, JH; Kaye, AD; Lindsay, D; Moyse, DW; Pyati, S; Qadri, MY, 2017) |
| "Ketamine intervention was found to significantly decrease narcotic use at 12 hours (SMD = -0." | 2.55 | Effect of intravenous ketamine for postoperative analgesia in patients undergoing laparoscopic cholecystectomy: A meta-analysis. ( Wu, Y; Ye, F; Zhou, C, 2017) |
| "Mechanistic approaches and multimodal analgesic techniques have been clearly demonstrated to be the most effective pain management strategy to improve outcomes." | 2.55 | Analgesia in the surgical intensive care unit. ( Brudney, CS; Ehieli, E; Pyati, S; Yalamuri, S, 2017) |
| "Chronic postoperative pain is common." | 2.53 | Preventing chronic postoperative pain. ( Reddi, D, 2016) |
| " Predefined subgroup analyses and meta-regression did not detect significant differences across subgroups, including a dose-response relationship." | 2.53 | Ketamine added to morphine or hydromorphone patient-controlled analgesia for acute postoperative pain in adults: a systematic review and meta-analysis of randomized trials. ( Cheng, D; Johnston, B; Kaushal, A; Martin, J; Wang, L; Zhu, F, 2016) |
| "Management of acute postoperative pain is important to decrease perioperative morbidity and improve patient satisfaction." | 2.53 | Managing Opioid-Tolerant Patients in the Perioperative Surgical Home. ( Baratta, JL; Schwenk, ES; Viscusi, ER; Wenzel, JT, 2016) |
| "Ketamine did not increase the prevalence of either postoperative nausea and vomiting or psychotomimetic complications." | 2.53 | Opioid-Sparing Effect of Ketamine in Children: A Meta-Analysis and Trial Sequential Analysis of Published Studies. ( Abdat, R; Brasher, C; Dahmani, S; Diallo, T; Hilly, J; Michelet, D; Skhiri, A, 2016) |
| "Only the analysis of postoperative pain at rest after 1 month resulted in a marginally significant reduction of chronic postoperative pain using ketamine in the perioperative setting." | 2.52 | Intra- and postoperative intravenous ketamine does not prevent chronic pain: A systematic review and meta-analysis. ( Bandschapp, O; Girard, T; Klatt, E; Ruppen, W; Zumbrunn, T, 2015) |
| " In controlled trials of neuropathic pain with topical ketamine combinations, there were improvements in some outcomes, but optimal dosing and drug combinations were not clear." | 2.50 | Topical and peripheral ketamine as an analgesic. ( Sawynok, J, 2014) |
| " Highly variable timing and dosing of ketamine in these studies suggest that no unifying effective regimen has emerged." | 2.50 | A systematic review and meta-analysis of ketamine for the prevention of persistent post-surgical pain. ( Haroutounian, S; McNicol, ED; Schumann, R, 2014) |
| "Ketamine was able to accomplish some preemptive analgesic effects of reducing postoperative morphine consumption and prolonging the time to first analgesic." | 2.50 | Preemptive analgesia effects of ketamine in patients undergoing surgery. A meta-analysis. ( Li, J; Yang, L; Zhang, C; Zhang, J; Zhang, Z; Zhao, D, 2014) |
| "Recent awareness that chronic pain may occur after childbirth has prompted clinicians and researchers to investigate this topic." | 2.49 | Chronic pain after childbirth. ( Bollag, L; Landau, R; Ortner, C, 2013) |
| "In the case of postoperative nausea and vomiting, administration of dexamethasone, droperidol and 5-HT3-antagonists is recommended, preferably in combination." | 2.49 | ['Postoperative pain treatment' practice guideline revised]. ( Hollmann, MW; Houweling, PL; Molag, ML; van Boekel, RL; van Haelst, IM; Verbrugge, SJ, 2013) |
| " We conclude that adding low-dose ketamine to morphine PCA is safe and post-thoracotomy may provide better pain control than PCA with morphine alone (PCA-MO), with reduced morphine consumption and possible improvement in respiratory function." | 2.48 | Does adding ketamine to morphine patient-controlled analgesia safely improve post-thoracotomy pain? ( Churchhouse, AM; Dunning, J; Housden, T; Mathews, TJ, 2012) |
| "Three types of hyperalgesia can occur during the postoperative period: primary hyperalgesia, which disappears with wound healing, secondary or central hyperalgesia, which can lead to chronic pain, and opiate-induced hyperalgesia." | 2.48 | [Prevention of postoperative hyperalgesia]. ( Mamie, C, 2012) |
| " They have been shown to help in reaching the desired effect when administered at drug-specific modes and at proven effective dosing throughout the perioperative period." | 2.48 | Non-opioid IV adjuvants in the perioperative period: pharmacological and clinical aspects of ketamine and gabapentinoids. ( Weinbroum, AA, 2012) |
| "When ketamine was efficacious for pain, postoperative nausea and vomiting was less frequent in the ketamine group." | 2.47 | A systematic review of intravenous ketamine for postoperative analgesia. ( Laskowski, K; Lim, HJ; McKay, WP; Stirling, A, 2011) |
| "The aim of this quantitative systematic review was to assess the efficacy and adverse effects of ketamine added to caudal local anaesthetics in comparison with local anaesthetics alone in children undergoing urological, lower abdominal, or lower limb surgery." | 2.47 | Efficacy and adverse effects of ketamine as an additive for paediatric caudal anaesthesia: a quantitative systematic review of randomized controlled trials. ( Kranke, P; Poepping, DM; Pogatzki-Zahn, EM; Schnabel, A; Zahn, PK, 2011) |
| "patient-controlled analgesia (PCA) for postoperative pain in order to clarify this controversy." | 2.46 | Adding ketamine to morphine for intravenous patient-controlled analgesia for acute postoperative pain: a qualitative review of randomized trials. ( Carstensen, M; Møller, AM, 2010) |
| "Adjuvants are compounds which by themselves have undesirable side-effects or low potency but in combination with opioids allow a reduction of narcotic dosing for postoperative pain control." | 2.44 | Useful adjuvants for postoperative pain management. ( Buvanendran, A; Kroin, JS, 2007) |
| "Recent advances in the understanding of postoperative pain have demonstrated its association with sensitization of the central nervous system (CNS) which clinically elicits pain hypersensitivity." | 2.44 | The clinical role of NMDA receptor antagonists for the treatment of postoperative pain. ( De Kock, MF; Lavand'homme, PM, 2007) |
| "The prevalences of complex regional pain syndrome, phantom limb pain, chronic donor-site pain, and persistent pain following total joint arthroplasty are alarmingly high." | 2.44 | Preventing the development of chronic pain after orthopaedic surgery with preventive multimodal analgesic techniques. ( Buvanendran, A; Reuben, SS, 2007) |
| "Weighted mean difference (WMD) for postoperative pain intensity (0-10 cm visual analogue scale) was -0." | 2.43 | Ketamine and postoperative pain--a quantitative systematic review of randomised trials. ( Elia, N; Tramèr, MR, 2005) |
| "Ketamine is a non-competitive antagonist to the phencyclidine site of N-methyl-d-aspartate (NMDA) receptor for glutamate, though its effects are mediated by interaction with many others receptors." | 2.43 | Ketamine: new indications for an old drug. ( Annetta, MG; Garisto, C; Iemma, D; Proietti, R; Tafani, C, 2005) |
| "Ketamine also reduces postoperative nausea and vomiting." | 2.43 | Perioperative ketamine for acute postoperative pain. ( Bell, RF; Dahl, JB; Kalso, E; Moore, RA, 2006) |
| "Dextromethorphan and ketamine were found to have significant immediate and preventive analgesic benefit in 67% and 58% of studies, respectively." | 2.42 | A qualitative systematic review of the role of N-methyl-D-aspartate receptor antagonists in preventive analgesia. ( Katz, J; McCartney, CJ; Sinha, A, 2004) |
| "Ketamine is an intravenous drug with special properties that make it the only agent that presently serves as anesthetic, sedative, amnesiac and analgesic." | 2.40 | [Ketamine]. ( González Miranda, F; Reboso Morales, JA, 1999) |
| "Ketamine hydrochloride is a well known general anesthetic and short acting analgesic in use for almost 3 decades." | 2.40 | Use and efficacy of low-dose ketamine in the management of acute postoperative pain: a review of current techniques and outcomes. ( Katz, J; Sandler, AN; Schmid, RL, 1999) |
| "Ketamine is an NMDA channel blocker, considered an alternative to perioperative opioid use; small concentrations are safe." | 1.91 | Impact of Perioperative Ketamine on Postoperative Bariatric Surgery Opioid Use and Length of Stay. ( Aghazarian, GS; Ardila, S; Ghanem, M; Jawad, MA; Lastrapes, L; Lind, R; Teixeira, AF, 2023) |
| "Early severe postoperative pain is frequently resistant to management with opioid analgesia alone." | 1.91 | A prospective observational study of the efficacy of ketamine for rescue analgesia in the postanesthesia recovery unit. ( Al Hamarneh, YN; Dillane, D; Green, J; Pan, B; Potvin, CA, 2023) |
| "Ketamine is an analgesic adjuvant useful in acute pain preventive treatment." | 1.91 | Postmastectomy analgesia with subcutaneous infiltration of ketamine with lidocaine in surgical wound. ( García-Posada, LD; Landeros-Navarro, IY; López-Garcés, VM; Santana-López, KS, 2023) |
| "There were no differences in postoperative pain scores and opioid consumption throughout their hospital stay between patients receiving concomitant dexmedetomidine and ketamine infusions versus patients who did not receive these infusions during thoracic surgery." | 1.72 | Intraoperative Dexmedetomidine and Ketamine Infusions in an Enhanced Recovery After Thoracic Surgery Program: A Propensity Score Matched Analysis. ( Joshi, G; Kruse, B; Lasala, JD; Mehran, R; Mena, GE; Patel, C; Rice, D; Vaporciyan, A; Williams, W; Woodward, T; Zorrilla-Vaca, A, 2022) |
| "Esketamine is used to control postoperative pain and reduce postoperative depression in surgical patients." | 1.72 | Effect of low-dose esketamine on pain control and postpartum depression after cesarean section: a retrospective cohort study. ( Dai, X; Luo, H; Wang, Y; Xiao, G; Zhang, Q, 2022) |
| "Acetaminophen was mixed with all 18 solutions and was examined at time 0, 15, 30, and 60 min." | 1.72 | Compatibility of intravenous acetaminophen with morphine, fentanyl and ketamine in acute pediatric pain setting. ( Chan, MTV; Cheaib, A; O'Loughlin, E; Peng, YG; Williams, R, 2022) |
| "Gabapentin has not been shown to improve patient outcomes; however, pregabalin may decrease pain and opioid use after total joint arthroplasty." | 1.72 | A Case Illustrating the Practical Application of the AAOS Clinical Practice Guideline: Pharmacologic, Physical, and Cognitive Pain Alleviation for Musculoskeletal Extremity/Pelvis Surgery. ( Patzkowski, JC; Patzkowski, MS, 2022) |
| "Postoperative pain was evaluated for 6 h after extubation using the visual analogue scale and the UNESP-Botucatu multidimensional composite pain scale for assessing postoperative pain in cats." | 1.62 | Antinociceptive and analgesic effect of continuous intravenous infusion of maropitant, lidocaine and ketamine alone or in combination in cats undergoing ovariohysterectomy. ( Beier, SL; Corrêa, JMX; Lavor, MSL; Marques, CSDC; Niella, RV; Oliveira, JNS; Pinto, TM; Silva Junior, AC; Silva, EBD; Silva, FL, 2021) |
| "Ketamine is a well-known anesthetic that has been used since the 1970s." | 1.62 | Examining Use of Low-Dose Ketamine Infusions During the Postoperative Period: A Retrospective Study Comparing Opioid-Tolerant and Nonopioid-Tolerant Patients. ( Cianci, MJ; Hebl, JR; Martin, EE; Mauck, WD; Ochs Kinney, MA, 2021) |
| "Even ketamine has an unpleasant taste." | 1.62 | Preanesthetic nebulized ketamine vs preanesthetic oral ketamine for sedation and postoperative pain management in children for elective surgery: A retrospective analysis for effectiveness and safety. ( Chen, C; Cheng, X; Fu, F; Lin, L, 2021) |
| " Kinetic analyses of MLK infusions in cattle are necessary to establish optimal dosing protocols and withdrawal intervals." | 1.56 | Analgesic efficacy of an intravenous constant rate infusion of a morphine-lidocaine-ketamine combination in Holstein calves undergoing umbilical herniorrhaphy. ( Coetzee, JF; Hartnack, AK; Kleinhenz, MD; Lakritz, J; Niehaus, AJ, 2020) |
| "Secondary outcomes included postoperative pain scores, requirement for postoperative morphine titration, total opioid analgesics consumption within the first 48 postoperative hours, incidence of nausea and vomiting, intraoperative haemodynamic." | 1.51 | Effect of opioid-free anaesthesia on postoperative epidural ropivacaine requirement after thoracic surgery: A retrospective unmatched case-control study. ( Bedon-Carte, S; Bello, M; Leo, F; Oger, S; Ouattara, A; Vielstadte, C; Zaouter, C, 2019) |
| " The primary objective of this pilot study is to determine if multiple dosing over a three-day perioperative period with oral ketamine is a safe treatment method for acute pain after amputation surgery." | 1.48 | Oral Ketamine for Acute Pain Management After Amputation Surgery. ( Buvanendran, A; Kroin, JS; Moric, M; Rajagopal, A; Robison, SJ; Tuman, KJ, 2018) |
| "In Chiari I patients, postoperative pain and discomfort frequently slow the transition back to the home setting." | 1.48 | Cost-Effectiveness of Postoperative Ketamine in Chiari Decompression. ( Alhourani, A; Friedlander, RM; Mazurkiewicz, A; McDowell, MM; Pearce-Smith, BA, 2018) |
| "Median postoperative pain scores were, at rest and at mobilization respectively 3 [IQR 2-4] and 6 [IQR 4." | 1.48 | Pain management in living related adult donor hepatectomy: feasibility of an evidence-based protocol in 100 consecutive donors. ( De Kock, M; Dewe, G; Forget, P; Lois, F; Reding, R; Steyaert, A, 2018) |
| "Allodynia/hyperalgesia area did not differ between groups and was infrequent and slight." | 1.46 | Incidence of persistent postoperative pain after hepatectomies with 2 regimes of perioperative analgesia containing ketamine. ( Coca, M; Gomar, C; Masgoret, P; Ríos, J; Taurá, P; Tena, B, 2017) |
| "Ketamine is a N-Metil-D-Aspartate receptor antagonist that has been used as adjuvant in the acute postoperative pain management because of its analgesic properties." | 1.46 | Is intravenous ketamine effective for postoperative pain management in adults? ( Altermatt, F; Lobos-Urbina, D; Stuardo, C, 2017) |
| "Ketamine is a non-competitive NMDA receptor antagonist that is widely used in alleviating postoperative pain, but its effect on CPOP has been rarely reported." | 1.43 | The effects of an intraperitoneal single low dose of ketamine in attenuating the postoperative skin/muscle incision and retraction-induced pain related to the inhibition of N-methyl-D-aspartate receptors in the spinal cord. ( Gu, X; Lei, Y; Liu, M; Ma, Z; Shen, Y; Xu, L, 2016) |
| "Ketamine is an N-methyl-d-aspartate (NMDA) receptor antagonist that provides potent analgesia without noticeable respiratory depression." | 1.43 | COMPARISON OF INTRAOPERATIVE KETAMINE VS. FENTANYL USE DECREASES POSTOPERATIVE OPIOID REQUIREMENTS IN TRAUMA PATIENTS UNDERGOING CERVICAL SPINE SURGERY. ( Angus, GL; Berkowitz, AC; Ginsburg, AM; Ginsburg, DB; Kang, A; Pesso, RM, 2016) |
| "Ketamine had less mechanical hyperalgesia in 6 h (p = 0." | 1.43 | A comparison of intrathecal magnesium and ketamine in attenuating remifentanil-induced hyperalgesia in rats. ( Ansong, E; Dong, J; Feng, X; Lin, H; Sun, J; Xu, X, 2016) |
| "Ketamine is a well-known anesthetic agent that has opioid-sparing analgesic properties, is noninvasive, and in analgesic doses, has few contraindications." | 1.42 | Perioperative ketamine for acute postoperative analgesia: the Mayo Clinic-Florida experience. ( Ardon, AE; Clendenen, AM; Howe, BL; Knestrick, BM; Mazer, LS; McClain, RL; Porter, SB, 2015) |
| "Persistent postsurgical pain has been defined by the International Association for the Study of Pain as clinical discomfort that lasts more than two months after surgery." | 1.42 | Potential strategies for preventing chronic postoperative pain: a practical approach: Continuing Professional Development. ( Brulotte, V; Julien, M; Richebé, P, 2015) |
| "Nitrous oxide inhalation has also been found to enhance the level of sensory spinal block." | 1.40 | The effects of intrathecal and systemic adjuvants on subarachnoid block. ( Paraskeva, A; Staikou, C, 2014) |
| " To ensure a safe dosing the age, body weight, duration of therapy, maximum daily dose and dosing intervals must be taken into account." | 1.40 | [Pediatric perioperative systemic pain therapy: Austrian interdisciplinary recommendations on pediatric perioperative pain management]. ( Grögl, G; Jaksch, W; Messerer, B; Stromer, W, 2014) |
| "Ketamine has been used in combination with a variety of other agents for intra-articular analgesia, with promising results." | 1.40 | Ketamine is toxic to chondrocyte cell cultures. ( Demir, T; Ergun, MA; Gungor, I; Kaya, K; Ozturk, AM; Yilmaz, A, 2014) |
| " The procedure was assessed by way ofaphysician-completed form and by evaluation of questionnaires given to parents to estimate levels of pain by using a 0 to 10 mm visual analog scale (VAS) at 2 hours after procedures and results in any adverse events with respect to age, gende, procedures performed, ketamine dosage and recovery time." | 1.40 | The factors of ketamine that affect sedation in children with oncology procedures: parent satisfaction perspective. ( Jindakam, W; Lumkul, R; Monsereenusorn, C; Rujkijyanont, P; Traivaree, C, 2014) |
| "Ketamine was used in 60 % of the cases." | 1.39 | [A French survey on the practice of analgesia for thoracic surgery]. ( Bastien, O; Dualé, C; Gayraud, G; Schoeffler, P; Taheri, H, 2013) |
| "Implementing an algorithm for postoperative pain management resulted in a clinically relevant reduction of postoperative pain." | 1.39 | [An algorithm for postoperative pain management in visceral and thoracic surgery: an observational study]. ( Fass, J; Gehling, M; Klammer, A; Klammer, F; Tryba, M, 2013) |
| "A 42 year-old woman with breast cancer and major depression resistant to medical treatment received a 90 minute intravenous infusion of 0." | 1.39 | [Effect of sub-anaesthetic doses of ketamine in the postoperative period in a patient with uncontrolled depression]. ( Alférez-García, I; Alonso-Menoyo, MB; Carricondo-Martínez, MA; Cortiñas-Saenz, M; Errando-Oyonarte, CL, 2013) |
| "The pentobarbital effect was significant within 3 days of surgery and persisted through the remainder of the testing period." | 1.37 | Deleterious impact of a γ-aminobutyric acid type A receptor preferring general anesthetic when used in the presence of persistent inflammation. ( Boegel, K; Gold, MS; Gyulai, FE; Moore, KK, 2011) |
| "To determine the pharmacokinetic parameters of xylazine, ketamine, and butorphanol (XKB) administered IM and sodium salicylate (SAL) administered PO to calves and to compare drug effects on biomarkers of pain and distress following sham and actual castration and dehorning." | 1.37 | Pharmacokinetics and physiologic effects of intramuscularly administered xylazine hydrochloride-ketamine hydrochloride-butorphanol tartrate alone or in combination with orally administered sodium salicylate on biomarkers of pain in Holstein calves followi ( Baldridge, SL; Coetzee, JF; Dritz, SS; Gehring, R; Havel, J; Kukanich, B; Reinbold, JB, 2011) |
| "Morphine was more effective in ketamine-treated (1 and 50 mg kg(-1)) mice." | 1.36 | Opioid-induced hyperalgesia in a mice model of orthopaedic pain: preventive effect of ketamine. ( Fourcade, O; Girolami, JP; Minville, V; Tack, I, 2010) |
| "Effects of preoperative ketamine on postoperative pain in patients undergoing laparotomy have been controversial." | 1.35 | [Effects of preoperative ketamine on postoperative pain in patients undergoing laparotomy]. ( Iwanaga, S; Kawamura, G; Kitamura, T; Ogawa, M; Ohno, N; Yamada, Y, 2008) |
| "Ketamine pretreatment prevented such a fentanyl-induced enhancement of postoperative pain and improved its management by morphine." | 1.33 | Ketamine improves the management of exaggerated postoperative pain observed in perioperative fentanyl-treated rats. ( Laulin, JP; Maurette, P; Richebé, P; Rivat, C; Simonnet, G, 2005) |
| "Xylazine and ketamine was administered simultaneously via intratesticularly (IT group), intramuscularly (IM group) or intravenously (IV group) at doses of 2 and 10 mg/kg, respectively." | 1.32 | Effect of intratesticular injection of xylazine/ketamine combination on canine castration. ( Jeong, MB; Jeong, SM; Kim, JK; Lee, ES; Nam, TC; Seo, KM; Yi, NY, 2004) |
| "Ketamine pretreatment (10 mg/kg) increased the fentanyl analgesic effect (4 x 60 microg/kg), suppressed the immediate hyperalgesic phase, and restored the full effect of a subsequent morphine injection." | 1.31 | The role of ketamine in preventing fentanyl-induced hyperalgesia and subsequent acute morphine tolerance. ( Chauvin, M; Corcuff, JB; Laulin, JP; Maurette, P; Rivat, C; Simonnet, G, 2002) |
| "Pre-emptive analgesia can improve postoperative pain management." | 1.30 | Pre-emptive analgesia with ketamine, morphine and epidural lidocaine prior to total knee replacement. ( Cherng, CH; Ho, ST; Lu, CC; Wong, CS, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 34 (4.90) | 18.7374 |
| 1990's | 48 (6.92) | 18.2507 |
| 2000's | 222 (31.99) | 29.6817 |
| 2010's | 265 (38.18) | 24.3611 |
| 2020's | 125 (18.01) | 2.80 |
| Authors | Studies |
|---|---|
| Carrara, L | 1 |
| Nault, M | 1 |
| Morisson, L | 1 |
| Godin, N | 1 |
| Idrissi, M | 1 |
| Fortier, A | 1 |
| Guertin, MC | 1 |
| Brulotte, V | 2 |
| Fortier, LP | 1 |
| Verdonck, O | 1 |
| Richebe, P | 4 |
| Wang, J | 9 |
| Chen, X | 2 |
| Guo, J | 2 |
| Hung, KC | 1 |
| Wu, SC | 1 |
| Chang, PC | 1 |
| Chen, IW | 1 |
| Hsing, CH | 1 |
| Lin, CM | 1 |
| Chen, JY | 2 |
| Chu, CC | 1 |
| Sun, CK | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Comparison of BIS Index Variations When i.v. Low-dose Ketamine is Administered Intraoperatively as Bolus Versus Continuous Infusion and Impact on the Anesthesia Gas Consumption.[NCT03781635] | Phase 4 | 50 participants (Actual) | Interventional | 2018-09-25 | Completed | ||
| Safety and Efficacy Evaluation of S（+）-Ketamine for Postoperative Acute Pain in Adults in Perioperative Settings: A Multicenter, Randomized, Open-label, Active Controlled Pragmatic Clinical Trial[NCT04837170] | Phase 4 | 12,000 participants (Anticipated) | Interventional | 2021-05-01 | Not yet recruiting | ||
| Bilateral Ultrasound-guided M-Tapa Block vs External Oblique Intercostal Block for Postoperative Analgesia in Patients Undergoing Laparoscopic Sleeve Gastrectomy Surgery: A Prospective Randomized Controlled Study[NCT05939635] | 60 participants (Anticipated) | Interventional | 2023-07-11 | Recruiting | |||
| Quality of Recovery of Opioid Free Anaesthesia Versus Opioids Anaesthesia Within Enhanced Recovery Protocol Following Laparoscopic Sleeve Gastrectomy in Saudi Arabia, Randomized Controlled Trial[NCT04285255] | 103 participants (Actual) | Interventional | 2020-03-01 | Completed | |||
| Effect of Intravenous Low-dose Esketamine on Maternal Depression at 2 Years After Childbirth in Women With Prenatal Depression: 2-year Follow-up of a Randomized Controlled Trial[NCT05698394] | Phase 4 | 364 participants (Actual) | Interventional | 2020-06-19 | Active, not recruiting | ||
| Postoperative Recovery in Patients Undergoing Forefoot Bone Surgery. A Comparative Study of the Occurrence of a Rebound Pain Phenomenon According to the Use of Either a Popliteal Sciatic Nerve Block or a Distal Sensory Ankle Block[NCT05734469] | 90 participants (Anticipated) | Interventional | 2023-02-15 | Not yet recruiting | |||
| Evaluation of Intraoperative Dexamethasone Efficacy to Prevent Rebound Pain Phenomenon According to Individual Patient Characteristics[NCT05763433] | 100 participants (Anticipated) | Observational | 2023-03-15 | Not yet recruiting | |||
| PCA Ketamine-Morphine Versus PCA Morphine as Post-Operative Analgesia in Colorectal Surgery[NCT06021717] | Phase 4 | 60 participants (Actual) | Interventional | 2018-04-05 | Completed | ||
| Safety and Efficacy Evaluation of S (+) -Ketamine for Postoperative Acute Pain in Children in Perioperative Settings: A Multicenter, Randomized, Open-label, Active Controlled Pragmatic Clinical Trial[NCT04834427] | Phase 4 | 3,000 participants (Anticipated) | Interventional | 2021-05-01 | Not yet recruiting | ||
| Ketamine for Acute Pain After Trauma: KAPT Trial[NCT04129086] | Phase 4 | 305 participants (Actual) | Interventional | 2020-07-01 | Completed | ||
| General Anesthesia Usiing Fentanyl Plus Propofol Plus Rococuronium Plus Isoflurane Versus Ketamime Plus Magnesium Sulphate Plus Lidocaine Plus Clonidine Plus Propofol Plus Rococuronium Plus Isoflurane in Gynaecology Surgery[NCT04737473] | 36 participants (Anticipated) | Interventional | 2020-01-06 | Recruiting | |||
| The Effect of Perioperative Intravenous Low-dose Ketamine on Acute and Chronic Neuropathic Pain After Major Back Surgery. A Randomised, Placebo-controlled, Double-blind Study[NCT00618423] | Phase 2 | 160 participants (Actual) | Interventional | 2007-10-31 | Completed | ||
| Evaluation of Intrathecal Neostigmine as an Adjuvant to Bupivacaine in Ameliorating Post-Dural Puncture Headache in Elective Caesarian Section: A Prospective Randomized Controlled Clinical Trial[NCT05289323] | Phase 4 | 722 participants (Actual) | Interventional | 2022-04-25 | Completed | ||
| Comparison of Esketamine-Propofol and Fentanyl-Propofol on Haemodynamics in Elderly Patients[NCT05752409] | 120 participants (Anticipated) | Interventional | 2021-10-08 | Recruiting | |||
| Effect of Intravenous S-ketamine on Opioid Consumption and Postoperative Pain in Patients Undergoing Breast Cancer Surgery：a Multicenter, Randomised, Control Trial[NCT05060068] | 352 participants (Anticipated) | Interventional | 2021-10-07 | Recruiting | |||
| Analgesic Effects of Low-dose S-ketamine in Patients Undergoing Major Spine Fusion Surgery: A Double-blinded, Randomized Controlled Trial[NCT04964219] | Phase 4 | 164 participants (Anticipated) | Interventional | 2022-02-08 | Recruiting | ||
| Opioid-Free Intravenous Anesthesia for Patients With Joint Hypermobility Syndrome Undergoing Craneo-Cervical Fixation: A Case-series Study Focused on Anti-hyperalgesic Approach[NCT04437589] | 42 participants (Actual) | Observational | 2018-09-06 | Completed | |||
| Intravenous Lignocaine as an Analgesic Adjunct in Adolescent Idiopathic Scoliosis Surgery (IGNITE-AIS Study)[NCT04931433] | Phase 4 | 102 participants (Anticipated) | Interventional | 2020-12-24 | Recruiting | ||
| Intravenous Lidocaine and Time to Regression of the Sensory Block After Spinal Anesthesia With Isobaric Bupivacaine in Patients Undergoing Surgery to Treat Skin and Soft Tissue Tumors of the Lower Limbs[NCT04741880] | Phase 2/Phase 3 | 66 participants (Anticipated) | Interventional | 2021-06-17 | Recruiting | ||
| Efficacy of Different Dose Esketamine and Dexmedetomidine Combination for Supplemental Analgesia After Scoliosis Correction Surgery: A Randomized, Double-blind Trial[NCT06062550] | Phase 4 | 312 participants (Anticipated) | Interventional | 2023-10-31 | Not yet recruiting | ||
| Impact of Different Dose Esketamine and Dexmedetomidine Combination for Supplemental Analgesia on Long-term Outcomes After Scoliosis Correction Surgery: Follow-up of a Randomized Trial[NCT06087510] | Phase 4 | 312 participants (Anticipated) | Interventional | 2024-01-31 | Not yet recruiting | ||
| Analgesia Effects of Intravenous Ketamine After Spinal Anesthesia for Non-elective Cesarean Section[NCT03450499] | Phase 4 | 80 participants (Actual) | Interventional | 2018-04-01 | Completed | ||
| Comparison Between the Analgesic Effects of Intrathecal Versus Intravenous Ketamine After Spinal Anaesthesia for Elective Caesarean Delivery :a Randomised Trial[NCT05679375] | Phase 4 | 60 participants (Anticipated) | Interventional | 2023-01-31 | Not yet recruiting | ||
| Caffeine and Neurologic Recovery Following Surgery and General Anesthesia[NCT03577730] | Early Phase 1 | 71 participants (Actual) | Interventional | 2018-07-10 | Completed | ||
| Effect of Electroacupuncture on the Incidence of Postoperative Delirium in Elderly Patients Undergoing the Major Surgery：a Prospective, Multicenter, Double-blind, Randomized Controlled Trial[NCT03606941] | 1,100 participants (Actual) | Interventional | 2018-09-07 | Completed | |||
| Effectiveness and Safety of Methylene Blue for Prevention of Postoperative Neurocognitive Disorders in Patients Undergoing Pancreatic Tumor Surgery: A Prospective Randomized Controlled Clinical Trial[NCT04529265] | 314 participants (Anticipated) | Interventional | 2021-05-01 | Recruiting | |||
| Intraoperative Infusion of Methylene Blue for Prevention of Postoperative Delirium and Cognitive Dysfunction in Elderly Patients Undergoing Major Elective Noncardiac and Nonneurosurgical Surgery[NCT04341844] | 248 participants (Actual) | Interventional | 2019-01-14 | Completed | |||
| The Prevention of Delirium and Complications Associated With Surgical Treatments Multi Center Clinical Trial[NCT01690988] | Phase 3 | 746 participants (Actual) | Interventional | 2014-02-01 | Completed | ||
| Intranasal Ketamine Versus Subcutaneous Ketamine for Treatment of Post Traumatic Acute Pain in the Emergency Department[NCT05229055] | Phase 2/Phase 3 | 1,000 participants (Anticipated) | Interventional | 2023-04-15 | Recruiting | ||
| The Effect and Contribution of a Perioperative Ketamine Infusion in an Established Enhanced Recovery Pathway[NCT04625283] | Phase 4 | 1,544 participants (Anticipated) | Interventional | 2021-04-12 | Enrolling by invitation | ||
| A Prospective, Open-Label Pilot Clinical Trial of Oral Ketamine for Acute Pain Management After Amputation Surgery[NCT02341963] | Phase 1 | 5 participants (Actual) | Interventional | 2015-01-31 | Terminated (stopped due to Recruitment issues) | ||
| Intra-operative Use of Ketamine for Post-Operative Analgesia in Patients Undergoing Hemorrhoidectomy: A Prospective, Randomized Controlled Trial.[NCT04248205] | Phase 4 | 100 participants (Anticipated) | Interventional | 2020-06-15 | Recruiting | ||
| The Effect of Ketamine on Production of Inflammatory Markers in Post Operative Patients in Mulago Hospital: A Randomized Clinical Trial[NCT01339065] | Phase 4 | 30 participants (Anticipated) | Interventional | 2011-04-30 | Recruiting | ||
| The Efficacy of Intraoperative Ketamine in Patients Undergoing Robot-assisted Thyroidectomy[NCT01997801] | 64 participants (Anticipated) | Interventional | 2013-12-31 | Not yet recruiting | |||
| Subcutaneous Ketamine for Postoperative Pain Relief in Rwanda: a Randomized Control Trial[NCT02514122] | Phase 2/Phase 3 | 61 participants (Actual) | Interventional | 2015-06-30 | Completed | ||
| Effects of Local Wound Infiltration With Ketamine Versus Dexmedetomidine Added to Bupivacaine on Surgical Stress Response and Postoperative Pain in Major Abdominal Cancer Surgery[NCT02927379] | Phase 3 | 90 participants (Actual) | Interventional | 2016-06-30 | Completed | ||
| Lidocaine and Ketamine in Abdominal Surgery[NCT04084548] | Phase 3 | 420 participants (Anticipated) | Interventional | 2019-10-15 | Recruiting | ||
| Low-dose S-ketamine and Dexmedetomidine in Combination With Opioids for Patient-controlled Analgesia After Scoliosis Correction Surgery: a Randomized, Double-blind, Placebo-controlled Trial[NCT04791059] | Phase 4 | 200 participants (Actual) | Interventional | 2021-04-09 | Completed | ||
| Effect of Mini-dose Esketamine-dexmedetomidine Supplemented Analgesia on Long-term Outcomes Following Scoliosis Correction Surgery: 2-year Follow-up of a Randomized Controlled Trial[NCT05718544] | Phase 4 | 199 participants (Actual) | Interventional | 2023-01-30 | Active, not recruiting | ||
| A Single Institutional Randomized Controlled Trial for A Multimodal Enhanced Recovery Program in Anorectal Surgery[NCT03992079] | 60 participants (Actual) | Interventional | 2019-06-20 | Terminated (stopped due to PI is no longer at institution) | |||
| Impact of Counseling and Education on Opioid Consumption After Anterior Cruciate Ligament Reconstruction: A Randomized Controlled Trial[NCT04885231] | 80 participants (Anticipated) | Interventional | 2021-05-12 | Active, not recruiting | |||
| Perioperative Use of Ketamine Infusion vs Dexmedetomidine Infusion as Analgesic in Obese Patients Undergoing Bariatric Surgery[NCT04576975] | Phase 3 | 90 participants (Actual) | Interventional | 2021-04-20 | Active, not recruiting | ||
| The Effect of Intraoperative Lidocaine Infusion and Intraoperative Lidocaine Combined With Ketamine Infusion on Opioid Consumption After Laparoscopic Bariatric Surgery: A Randomized Controlled Trial[NCT04524130] | Phase 4 | 87 participants (Anticipated) | Interventional | 2021-04-01 | Active, not recruiting | ||
| Randomized, Double-blind, Placebo Controlled Study on the Effect of a Single Postoperative Administration of Low Dose Ketamine After Gastric Bypass and Gastrectomy Surgeries[NCT02452060] | Phase 2/Phase 3 | 90 participants (Actual) | Interventional | 2014-10-31 | Completed | ||
| A Prospective, Randomized, Double Blinded Comparison of Ketamine Infusion Versus Placebo in Opioid Tolerant and Opioid Naive Patients After Spinal Fusion[NCT03274453] | Phase 2 | 129 participants (Actual) | Interventional | 2012-11-01 | Completed | ||
| "Continuous Thoracic Epidural Analgesia Versus Continuous Erector Spinae Plane Block for Postoperative Analgesia in Patients Undergoing Adult Living Donar Open Hepatectomies."[NCT04151511] | 60 participants (Anticipated) | Interventional | 2019-10-19 | Recruiting | |||
| Ultrasound-guided Bilateral Erector Spinalis Plane Block on Postoperative Pain Management in Liver Transplantation Donors[NCT05406388] | 41 participants (Actual) | Interventional | 2020-12-24 | Completed | |||
| The Effect of Low-dose of S-ketamine Combined With Sufentanil for Postoperative Patient-controlled Intravenous Analgesia in Patients Following Cesarean Section[NCT05299866] | Phase 4 | 216 participants (Anticipated) | Interventional | 2022-04-12 | Recruiting | ||
| Observational Study of the Efficacy of Ketamine for Rescue Analgesia in the Post Anesthesia Recovery Room[NCT04701008] | 143 participants (Actual) | Observational | 2020-09-01 | Completed | |||
| A Double-blind, Randomised Placebo-controlled Trial to Determine Whether Low-dose Intravenous Ketamine Peri-operatively Can Prevent Chronic Post-surgical Pain, in Patients Undergoing Thoracotomy or Video Assisted Thoracic Surgery (VATS)[NCT01296347] | Phase 4 | 77 participants (Actual) | Interventional | 2011-04-30 | Completed | ||
| The Efficacy and Safety of Opioid-free Anesthesia(OFA) for Non-small-cell Lung Cancer Resection and Its Underlying Clinical Value: a Prospective Study[NCT05063396] | 60 participants (Anticipated) | Interventional | 2021-10-01 | Recruiting | |||
| Pain Intensity After RObotic Assisted Urological Surgery: the PAIROU Study[NCT05575284] | 968 participants (Actual) | Observational | 2022-12-01 | Completed | |||
| Peri-Operative Pregabalin for Reducing opIoid Consumption AfTer Cardiac surgEry: A Randomized Trial[NCT04517110] | Phase 3 | 17 participants (Actual) | Interventional | 2021-04-09 | Terminated (stopped due to The COVID-19 pandemic has reduced recruitment such that the study is no longer feasible) | ||
| Opioid Free Anaesthesia in Cardiac Surgery With Cardiopulmonary Bypas[NCT03816592] | 110 participants (Actual) | Observational | 2019-01-01 | Completed | |||
| The Postoperative Opioid-Sparing Effect of an Intraoperative Pecto-Intercostal Fascial Block and Opioid-Free Anesthesia in Cardiac Surgery Patients: a Prospective Randomized Controlled Trial[NCT04854577] | 64 participants (Anticipated) | Interventional | 2021-05-31 | Not yet recruiting | |||
| Effect of Tramadol on Postoperative Sore Throat in Thyroid Surgery Under General Anesthesia With Endotracheal Intubation: A Randomized Controlled Trial[NCT04991493] | Phase 4 | 168 participants (Anticipated) | Interventional | 2021-09-10 | Recruiting | ||
| Is The Pre-Emptive Administration Of Ketamine A Significant Adjunction To Intravenous Morphine Analgesia For Controlling Post-Operative Pain? A Randomized, Double Blind, Placebo Controlled Clinical Trial.[NCT03415191] | 75 participants (Actual) | Interventional | 2012-01-05 | Completed | |||
| A Safe Ketamine-Based Therapy for Treatment Resistant Depression[NCT01179009] | 20 participants (Actual) | Interventional | 2012-04-30 | Completed | |||
| Comparison of Effect of Peritonsillar Infiltration of Ketamine and Tramadol on Pediatric Posttonsillectomy Pain: A Double-blinded Randomized Placebo-controlled Clinical Trial[NCT03067103] | Phase 4 | 108 participants (Anticipated) | Interventional | 2017-07-01 | Not yet recruiting | ||
| The Check Trial: A Comparison of Headache Treatment in the ED: Compazine Versus Ketamine. A Multi-Center, Randomized Double-Blind, Clinical Control Trial.[NCT02657031] | Phase 4 | 54 participants (Actual) | Interventional | 2016-03-17 | Completed | ||
| Opioid-Free Shoulder Arthroplasty[NCT03540030] | Phase 4 | 86 participants (Actual) | Interventional | 2016-09-30 | Completed | ||
| Efficacy and Side Effects of Intrathecal Morphine in Multimodal Analgesia for Unilateral Total Knee Arthroplasty[NCT03232957] | 131 participants (Actual) | Interventional | 2017-08-01 | Completed | |||
| Effect of Paracetamol and Ibuprofen When Intravenously Given Combination or Alone in Reducing Morphine Requirements After Total Knee Arthroplasty[NCT04414995] | Phase 2/Phase 3 | 36 participants (Actual) | Interventional | 2020-06-05 | Completed | ||
| Effect of Perioperative Electroacupuncture With Tramadol and Ketamine on Postoperative Analgesia in Prostatectomy: a Randomized Placebo-controlled Trial[NCT01526525] | Phase 4 | 70 participants (Actual) | Interventional | 2009-07-31 | Completed | ||
| [NCT01404442] | Phase 1/Phase 2 | 90 participants (Actual) | Interventional | 2011-05-31 | Completed | ||
| The Comparison of Analgesia Methods Used for Spinal Surgery[NCT04603638] | 82 participants (Anticipated) | Interventional | 2020-03-04 | Recruiting | |||
| The Effect of a Regimen of Opioid Sparing Anesthesia on Postoperative Recovery[NCT05594407] | 60 participants (Anticipated) | Interventional | 2022-08-01 | Recruiting | |||
| Modulation of μ Opioid Receptor Mediated Analgesia, Tolerance and Hyperalgesia in Children and Adolescents[NCT01325493] | Phase 4 | 54 participants (Actual) | Interventional | 2010-01-31 | Completed | ||
| Persistent Postsurgical Pain (PPSP) Following Cystectomy: A Survey and Sensory Examination[NCT02751346] | 383 participants (Actual) | Observational | 2016-01-31 | Completed | |||
| Nebulized Midazolam, Dexmedetomidine, and Their Combination in Sedation of Preschoolers Undergoing Dental Treatment: A Randomized Clinical Trial[NCT03827408] | Phase 2 | 72 participants (Actual) | Interventional | 2017-11-27 | Completed | ||
| Randomized Controlled Trial of IN Midazolam vs IN Dexmedetomidine vs IN Ketamine Evaluating Length of Stay After Medication Administration and Anxiolysis During Minimal Procedures in Pediatric Population in Pediatric Emergency Department[NCT05934669] | Phase 4 | 90 participants (Anticipated) | Interventional | 2024-01-31 | Not yet recruiting | ||
| (2R,6R)-Hydroxynorketamine a Novel Therapeutic Analgesic for the Treatment of Neuropathic Pain: A Randomized Double Blind Cross-Over Trial.[NCT05864053] | Phase 1/Phase 2 | 25 participants (Anticipated) | Interventional | 2024-01-31 | Not yet recruiting | ||
| Emergence Delirium in Children: a Randomized Clinical Trial of Different Doses of Sevoflurane During Induction of Anesthesia[NCT02707016] | 80 participants (Anticipated) | Interventional | 2015-12-31 | Recruiting | |||
| KETODEX for Emergence Delirium in Children Undergoing Outpatient Strabismus Surgery[NCT03779282] | 90 participants (Actual) | Observational | 2018-02-15 | Completed | |||
| Comparison of Oral Chloral Hydrate and Combination of Intranasal Dexmedetomidine and Ketamine for Rescue After Failed Pediatric Procedural Sedation: a Randomized Controlled Trial[NCT04822064] | 70 participants (Anticipated) | Interventional | 2022-09-22 | Recruiting | |||
| Comparison of Oral Chloral Hydrate and Combination of Intranasal Dexmedetomidine and Ketamine for Procedural Sedation in Children: a Randomized Controlled Trial[NCT04820205] | 136 participants (Anticipated) | Interventional | 2021-09-03 | Recruiting | |||
| Cardiovascular and Neuropsychiatric Side Effects in Ketamine Analgesic Infusions in Acute Pain[NCT03979105] | 300 participants (Actual) | Observational | 2017-07-01 | Completed | |||
| Comparison of Different Strategies in Preventing Discomfort Due to Urine Catheter in Urinary Surgery[NCT04314050] | 135 participants (Actual) | Interventional | 2020-03-10 | Completed | |||
| The Effect of Intravenous Infusions of Lidocaine and Magnesium Versus Lidocaine and Ketamine Versus Lidocaine Alone on Recovery Profile and Postoperative Pain After Elective Gynecological Surgery[NCT04622904] | 90 participants (Anticipated) | Interventional | 2020-11-14 | Recruiting | |||
| Effect of Intraoperative IV Ketamine on Postoperative Morphine Consumption During Intestinal Surgery and Its Effect on Salivary Cortisol and Alpha Amylase Levels[NCT03344393] | 60 participants (Anticipated) | Interventional | 2017-12-01 | Not yet recruiting | |||
| Midazolam Effect on Agitation Postnasal Surgery: A Double Blinded Randomized Controlled Trial[NCT05165914] | 100 participants (Actual) | Interventional | 2021-05-27 | Completed | |||
| Impact of Night-time Dexmedetomidine-esketamine Infusion on Sleep Quality of Patients With Mechanical Ventilation in ICU: a Randomized Controlled Trial[NCT05718024] | Phase 4 | 174 participants (Anticipated) | Interventional | 2023-12-31 | Not yet recruiting | ||
| Effect of Mini-dose Dexmedetomidine-Esketamine Infusion on Sleep Quality in Older Patients Undergoing Knee or Hip Replacement Surgery: A Multicenter Randomized Controlled Trial[NCT05950646] | Phase 4 | 154 participants (Anticipated) | Interventional | 2023-11-01 | Recruiting | ||
| Dexmedetomidine-esketamine Combined With Oxycodone for Ultrasound-guided Percutaneous Radiofrequency Ablation in Patients With Liver Cancer: a Randomized Controlled Study[NCT06003218] | 88 participants (Anticipated) | Interventional | 2023-10-16 | Recruiting | |||
| Effects of Low-dose Dexmedetomidine-esketamine Combined Nasal Administration at Night on Perioperative Sleep Quality in Breast Cancer Patients: a Randomized, Double-blind, Placebo-controlled Trial[NCT05732064] | Phase 4 | 180 participants (Anticipated) | Interventional | 2023-05-22 | Recruiting | ||
| A Randomized Controlled Trial to Determine the Efficacy of Ketamine as an Adjunct for Pain Management in Patients With Sickle Cell Crisis[NCT03502421] | Phase 3 | 0 participants (Actual) | Interventional | 2018-09-01 | Withdrawn (stopped due to Never IRB approved, no intention to proceed with the study) | ||
| A Prospective, Randomized, Double-Blind, Controlled Trial Evaluating the Efficacy of Ketamine for Improvement in Postoperative Pain Control After Spinal Fusion for Idiopathic Scoliosis[NCT02651324] | Phase 4 | 50 participants (Anticipated) | Interventional | 2013-05-31 | Active, not recruiting | ||
| A Prospective, Randomized, Single Blinded Comparison of Intraoperative Ketamine Infusion Versus Placebo in Patients Having Spinal Fusion[NCT02424591] | Phase 4 | 46 participants (Actual) | Interventional | 2014-08-31 | Completed | ||
| Comparison of Sub-dissociative Intranasal Ketamine Plus Standard Pain Therapy Versus Standard Pain Therapy in the Treatment of Pediatric Sickle Cell Disease Vasoocclusive Crises in Resource-limited Settings: a Multi-centered, Randomized, Controlled Trial[NCT02573714] | 160 participants (Anticipated) | Interventional | 2015-12-31 | Recruiting | |||
| Ketamine Improves Post-Thoracotomy Analgesia[NCT00625911] | 44 participants (Actual) | Interventional | 2001-09-30 | Completed | |||
| Effects of Perioperative Systemic Ketamine on Development of Long-term Neuropathic Pain After Thoracotomy.[NCT00313378] | Phase 3 | 78 participants (Actual) | Interventional | 2004-04-30 | Completed | ||
| Low Dose Ketamine Infusion for Postoperative Analgesia After Total Knee Arthroplasty: Optimum Dose to Reduce Morphine Consumption[NCT04085588] | 75 participants (Actual) | Observational | 2019-04-15 | Completed | |||
| Evaluation of the Effect of Ketamine on Remifentanil-induced Hyperalgesia Using Filaments, an Algometer, and Interleukins: a Double-blind, Randomized Study[NCT01301079] | Phase 3 | 60 participants (Actual) | Interventional | 2010-09-30 | Completed | ||
| Effect of Ultra-low Dose Naloxone on Remifentanil-Induced Hyperalgesia[NCT03066739] | Phase 2 | 105 participants (Anticipated) | Interventional | 2023-02-25 | Recruiting | ||
| Ketamine, Lidocaine and Combination for Postoperative Analgesia in Open Liver Resection: A Prospective, Randomized, Four-arm, Double Blind, Placebo Controlled Trial[NCT03391427] | 124 participants (Actual) | Interventional | 2011-03-01 | Completed | |||
| The Effect of Magnesium Sulfate Infusion on the Quality of Recovery of Ambulatory Patients[NCT01433081] | 50 participants (Actual) | Interventional | 2011-02-28 | Completed | |||
| Effect of a Multimodal Pain Regimen on Pain Control, Patient Satisfaction and Narcotic Use in Orthopaedic Trauma Patients[NCT02160301] | Phase 4 | 0 participants (Actual) | Interventional | 2017-11-30 | Withdrawn (stopped due to Insufficient infrastructure/funding for enrollment) | ||
| Do Peri-operative High Doses of Intravenous Glucocorticoids Improve Short-term Functional Outcome After Direct Anterior Total Hip Arthroplasty? A Randomized, Single Surgeon, Placebo Controlled, Double Blind Study[NCT04317872] | 70 participants (Anticipated) | Interventional | 2020-07-01 | Recruiting | |||
| Pre-Emptive Analgesia in Ano-Rectal Surgery[NCT02402543] | 90 participants (Actual) | Interventional | 2014-06-30 | Completed | |||
| STTEPP: Safety, Tolerability and Dose Limiting Toxicity of Lacosamide in Patients With Painful Chronic Pancreatitis[NCT05603702] | Phase 1 | 24 participants (Anticipated) | Interventional | 2023-03-17 | Recruiting | ||
| PCA Ketamine-Morphine Versus PCA Morphine as Post-Operative Analgesia in Colorectal Surgery.[NCT06010056] | Phase 4 | 60 participants (Actual) | Interventional | 2018-04-05 | Completed | ||
| Prospective Randomized Double Blind Study of Intraoperative Dexmedetomidine and Postoperative Pain Control in Patients Undergoing Multi-level Thoraco-lumbar Spine Surgery[NCT01850017] | Phase 4 | 142 participants (Actual) | Interventional | 2012-08-31 | Completed | ||
| The Effect of Intraoperative Ketamine on Opioid Consumption and Pain After Spine Surgery in Opioid-dependent Patients[NCT02085577] | Phase 4 | 147 participants (Actual) | Interventional | 2014-05-31 | Completed | ||
| A Prospective, Block Randomized, Double-Blind Placebo-Controlled Trial of Ketamine in Patients Undergoing Anterior Cervical Discectomy and Fusion[NCT02378740] | Phase 4 | 0 participants (Actual) | Interventional | 2015-04-30 | Withdrawn (stopped due to PI has left the University) | ||
| Dexmedetomidine Versus Fentanyl Added to Levobupivacaine for Transversus Abdominis Plane (TAP) Block in Elderly Patients Undergoing Lower Abdominal Surgery[NCT03778671] | Phase 1/Phase 2 | 90 participants (Actual) | Interventional | 2019-01-01 | Completed | ||
| Postpartum Perineal Pain After Obstetric Anal Sphincter Injuries: A Randomized Clinical Trial[NCT03470675] | Phase 4 | 67 participants (Actual) | Interventional | 2018-06-27 | Active, not recruiting | ||
| Ketamine Treatment for Pediatric-Refractory Obsessive-Compulsive Disorder (OCD)[NCT02422290] | Phase 1/Phase 2 | 5 participants (Actual) | Interventional | 2015-03-31 | Completed | ||
| EARLY PREOPERATIVE ESCALATING DOSES OF KETAMINE ATTENUATE POSTOPERATIVE PAIN AND REDUCE MORPHINE CONSUMPTION IN HUMANS[NCT01070108] | 120 participants (Actual) | Interventional | 2007-01-31 | Completed | |||
| Comparison of Lidocaine, Dexmedetomidine and Ketamine in Multimodal Analgesia Management Following Sleeve Gastrectomy Surgery: A Randomized Double-Blind Trial[NCT04836819] | 78 participants (Actual) | Interventional | 2021-04-08 | Completed | |||
| Neuropsychiatric and Cardiovascular Side Effects in Ketamine Analgesic Infusions: a Prospective Study[NCT03525912] | 101 participants (Actual) | Interventional | 2017-07-01 | Completed | |||
| Effects of Different Concentrations of Esketamine on Postpartum Depression After Cesarean Section[NCT05229913] | Phase 4 | 500 participants (Anticipated) | Interventional | 2022-02-20 | Not yet recruiting | ||
| The Effect of Ongoing Beta-blockers Administration on Analgesic Requirements in the Immediate Perioperative Period.[NCT03498898] | 120 participants (Anticipated) | Interventional | 2018-06-01 | Recruiting | |||
| Intraoperative Lidocaine Infusion vs. Esmolol Infusion for Postoperative Analgesia in Laparoscopic Cholecystectomy: a Randomized Clinical Trial[NCT02327923] | Phase 4 | 90 participants (Actual) | Interventional | 2015-01-31 | Completed | ||
| The Influence of Age on EEG Signals and Consciousness During Anesthesia (TIARA)[NCT04765046] | 90 participants (Actual) | Interventional | 2021-08-18 | Completed | |||
| A Comparison of Epidural Analgesia With Standard Care Following Lumbar Spinal Fusion: A Prospective Randomized Study[NCT01986946] | Phase 3 | 17 participants (Actual) | Interventional | 2013-10-31 | Terminated (stopped due to Lack of recruitment.) | ||
| Postoperative Analgesic Efficacy of the Pulmonary Recruitment Maneuver Compared to Intraperitoneal Hydrocortisone in Laparoscopic Gynecological Surgery[NCT03845608] | Phase 4 | 45 participants (Anticipated) | Interventional | 2019-03-31 | Not yet recruiting | ||
| Diclofenac Premedication, as the Effect of Preemptive Analgesia After Post-thoracotomy Chest and Shoulder Pain, as Well as the Changes of the Postoperative Breathing Function Values, a Randomized, Controlled, Prospective Trial[NCT02445599] | Phase 4 | 3 participants (Actual) | Interventional | 2014-04-30 | Completed | ||
| Association of Intravenous Ketamine With Thoracic Epidural Analgesia: Effects on Pain and Respiratory Function Following Thoracotomy.[NCT00726258] | 21 participants (Actual) | Interventional | 2008-03-31 | Terminated | |||
| Single-dose Intraoperative Methadone for Early Ambulation and Sustained Pain Control in Spinal Fusion Surgery Patients[NCT02989597] | Phase 4 | 10 participants (Actual) | Interventional | 2017-07-29 | Terminated (stopped due to Due to personnel loss and logistical issues the study was unable to be completed as planned.) | ||
| Effect of Intravenous Nalbuphine on Emergence Agitation in Children Undergoing Repair of Rupture Globe[NCT03470077] | Phase 2 | 80 participants (Actual) | Interventional | 2019-07-31 | Completed | ||
| Efficacy of Continuous Infusion of Levobupivacaine to the Surgical Wound Following Cesarean[NCT01458431] | Phase 3 | 70 participants (Actual) | Interventional | 2011-10-31 | Completed | ||
| Effect of Intravenous Paracetamol in Combination With Caudal Ropivacaine on Quality of Postoperative Recovery in Paediatric Patients Undergoing Hypospadias Repair[NCT03781505] | Phase 4 | 64 participants (Anticipated) | Interventional | 2019-01-31 | Recruiting | ||
| Analgesic Effects of Caudal S-ketamine for Supplementation of Ropivacaine Caudal Analgesia in Children With Hypospadias[NCT05922605] | Phase 4 | 44 participants (Anticipated) | Interventional | 2023-06-20 | Recruiting | ||
| Does a Single Intravenous Dose of Ketamine Reduce the Need for Supplemental Opioids in Post-Cesarean Section Patients?[NCT00486902] | 188 participants (Actual) | Interventional | 2006-07-31 | Completed | |||
| Phenomics and Genomics of Clinically Relevant Chronic Postsurgical Pain: A Multicenter Prospective Study[NCT04798573] | 10,000 participants (Anticipated) | Observational | 2012-08-03 | Active, not recruiting | |||
| Effect of Perioperative i.v. Low-dose S(+) Ketamine in Patients Undergoing Hemorrhoidectomy[NCT00354029] | Phase 4 | 83 participants (Actual) | Interventional | 2006-08-31 | Completed | ||
| Study of the Efficacity of the Systemic Ketamine for the Improvement of Post-Operative Analgesia After ORL Carcinological Surgery at the Alcohol-Dependent Patient.[NCT00329394] | Phase 3 | 56 participants (Anticipated) | Interventional | 2006-04-30 | Suspended | ||
| Spreading Depolarization and Ketamine Suppression[NCT02501941] | Phase 1 | 10 participants (Actual) | Interventional | 2015-07-31 | Completed | ||
| Anxiolysis for Emergency Department Procedures in Pediatric Patients Using Intranasal Ketamine Compared With Intranasal Midazolam: A Randomized Controlled Trial[NCT03043430] | Phase 4 | 10 participants (Actual) | Interventional | 2016-05-31 | Terminated (stopped due to Research manpower shortage) | ||
| Fentanyl Ultra Low Doses Effects on Human Volunteer's Nociceptive Threshold. Towards a Simple Pharmacological Test Able to Predict Pain Vulnerability, Post Operative Hyperalgesia Development Risk?[NCT00454259] | Phase 4 | 48 participants (Actual) | Interventional | 2007-03-31 | Completed | ||
| Influence of Intraoperative Analgesia (Sufentanil Administered According to the Usual Criteria or Remifentanil Administered by a Closed-loop System Using Bispectral Index as the Controller) on the Postoperative Morphine Consumption[NCT00772616] | Phase 4 | 60 participants (Actual) | Interventional | 2008-09-30 | Completed | ||
| Efficacy of S(+)-Ketamine Administered as a Continuous Infusion for the Control of Postoperative Pain: a Randomized Controlled Trial[NCT02421913] | Phase 4 | 42 participants (Actual) | Interventional | 2012-06-30 | Completed | ||
| Administration of Acetazolamide to Prevent Remifentanil Induced Hyperalgesia: Randomize Double Blind Clinical Trial[NCT02992938] | Phase 4 | 50 participants (Actual) | Interventional | 2016-12-31 | Completed | ||
| Effect of Remifentanil on the Recovery Profile After Prolonged Head and Neck Surgery[NCT02416752] | 222 participants (Actual) | Observational | 2011-08-31 | Completed | |||
| Can Opioid-induced Hyperalgesia be Prevented by Gradual Dose Reduction vs. Abrupt Withdrawal of Remifentanil?[NCT01702389] | Phase 4 | 16 participants (Actual) | Interventional | 2012-10-31 | Completed | ||
| Proportional Ventilation and Ventilatory Synchronism[NCT00133939] | 10 participants | Interventional | Recruiting | ||||
| Analgesic Efficacy of Preoperative Oral Administration of Dexketoprofen Trometamol in Third Molar Surgery, Compared to Postoperative Administration[NCT02380001] | Phase 4 | 60 participants (Actual) | Interventional | 2015-01-31 | Completed | ||
| Transversus Abdominis Plane (TAP) Block for Cesarean Section[NCT01015807] | 90 participants (Actual) | Interventional | 2009-11-30 | Completed | |||
| Pregabalin for the Treatment of Pain After Posterior Spinal Fusions.[NCT01366196] | 86 participants (Actual) | Interventional | 2008-10-31 | Completed | |||
| Gabapentin as a Pre-emptive Analgesic in Oral and Maxillofacial Surgical Procedures[NCT02957097] | Phase 4 | 0 participants (Actual) | Interventional | 2019-09-30 | Withdrawn (stopped due to Original PI left institution and the PI who took over was not able to initiate the study so it was never started.) | ||
| Ketamine Frequency Treatment for Major Depressive Disorder[NCT00646087] | Phase 4 | 0 participants (Actual) | Interventional | 2008-03-31 | Withdrawn (stopped due to Pilot study determined that this study would not be feasible.) | ||
| Comparing the Effectiveness of Low-dose Ketamine With Morphine to Treat Pain in Patients With Long Bone Fractures[NCT02430818] | 13 participants (Actual) | Interventional | 2015-04-30 | Terminated (stopped due to were not able to enroll patients to a satisfactory level) | |||
| Effect of Pregabalin Administration on Catheter- Related Bladder Discomfort in Urological Surgical Operations[NCT03229668] | Phase 2/Phase 3 | 78 participants (Actual) | Interventional | 2017-07-28 | Completed | ||
| Phase 4 Study of Prevention of Persistent Postsurgical Pain After Thoracotomy Using Ketamine[NCT01243801] | Phase 4 | 104 participants (Actual) | Interventional | 2008-09-30 | Completed | ||
| Low Dose Intraoperative Intravenous Ketamine in Combination With Multilevel Paravertebral Block for Post Video-assisted Thoracic Surgery Pain: a Randomized Study[NCT03280017] | Phase 4 | 32 participants (Actual) | Interventional | 2017-09-25 | Completed | ||
| Inhaled Nebulised S(+)-Ketamine for Postoperative Analgesia[NCT02397356] | Phase 4 | 0 participants (Actual) | Interventional | 2018-08-31 | Withdrawn (stopped due to Lack of study personnel) | ||
| Magnesium Oral Supplementation to Reduce Pain in Patients With Severe Peripheral Arterial Occlusive Disease: The MAG-PAPER Randomized Clinical Trial[NCT02455726] | 150 participants (Anticipated) | Interventional | 2015-09-30 | Not yet recruiting | |||
| Double Blind, Randomized, Placebo Controlled Clinical Trial to Evaluate the Efficacy of Repetitive Transcranial Magnetic Stimulation in Patients Victims of Landmines With Phantom Limb Pain[NCT01872481] | Phase 3 | 54 participants (Actual) | Interventional | 2013-06-30 | Completed | ||
| Low Dose Spinal Morphine for Patients With Obstructive Sleep Apnea (OSA) Undergoing Total Hip Arthroplasty (THA)[NCT01790971] | 40 participants (Anticipated) | Interventional | 2020-01-31 | Suspended (stopped due to competing studies) | |||
| Quality of Recovery Following Administration of Transverse Abdominus Plane (TAP) Catheter as Compared to Intrathecal Morphine After Cesarean Delivery Under Spinal Anesthesia: a Prospective, Randomized Trial[NCT01593280] | 80 participants (Anticipated) | Interventional | 2012-05-31 | Recruiting | |||
| Naloxone Block of Low-dose (Analgetic Dose) Ketamine[NCT00921765] | Phase 4 | 3 participants (Actual) | Interventional | 2009-12-31 | Terminated (stopped due to Problems with patient recruitment) | ||
| Study of the Efficiency of the Ketamine With Low Analgesic Doses, in Association With High Opioids, in the Treatment of the Rebels Pains, in Palliative Phase of the Cancerous Disease[NCT01326325] | Phase 3 | 24 participants (Actual) | Interventional | 2011-07-31 | Completed | ||
| The Use of Ketamine as Rescue Analgesia in the Recovery Room Following Opioid Administration. A Double-blind Randomised Trial in Postoperative Patients.[NCT00163969] | Phase 4 | 40 participants | Interventional | 2002-04-30 | Completed | ||
| Comparison of Intravenous Push Dose of Low Dose Ketamine to Short Infusion of Low Dose Ketamine for Treatment of Moderate to Severe Pain in the Emergency Department: A Prospective, Randomized, Double-Blind Study[NCT02363270] | 48 participants (Actual) | Interventional | 2015-04-01 | Completed | |||
| Low Dose Ketamine Versus Morphine for Moderate to Severe Pain in the Emergency Department: A Prospective, Randomized, Double-Blind Study[NCT01835262] | Phase 4 | 90 participants (Actual) | Interventional | 2013-04-30 | Completed | ||
| A Prospective, Randomized, Double-Blind, Active-Comparator, Pilot Study to Observe Relative Efficacy of Ultrasound-Guided Erector Spinae Plane Block (ESP) vs. Combination of Ultrasound - Guided Erector Spinae Plane Block With Serratus Anterior Plane Block[NCT04349774] | Phase 4 | 0 participants (Actual) | Interventional | 2022-10-01 | Withdrawn (stopped due to Study was never initiated due to COVID-19) | ||
| The cryoICE™ CryoAnalgesia Study For Pain Management in Post thoRacic Procedures Via intercOSTal Cryoanalgesia (FROST)[NCT02922153] | 84 participants (Actual) | Interventional | 2016-06-13 | Completed | |||
| Comparison of Caudal Bupivacaine Alone With Bupivacaine Plus Two Doses of Dexmedetomidine for Postoperative Analgesia in Pediatric Patients Undergoing Infra-umbilical Surgery: A Randomized Controlled Double Blinded Study[NCT02385435] | Phase 2/Phase 3 | 91 participants (Actual) | Interventional | 2014-01-31 | Completed | ||
| Assessment of the Analgesic Efficacy and Tolerability of the Perioperative Association of the Ketamine With Opiates After Posterior Vertebral Fusion Surgery in Children With Idiopathic Scoliosis[NCT02571491] | Phase 2 | 48 participants (Actual) | Interventional | 2012-01-31 | Completed | ||
| Low-Dose Ketamine Versus Morphine for Moderate to Severe Pain in the Emergency Department Geriatric Population: A Prospective, Randomized, Double-Blind Study.[NCT02673372] | Phase 4 | 60 participants (Actual) | Interventional | 2016-04-30 | Completed | ||
| The Effects of Subanesthetic Ketamine on Respiratory Stimulation and Transpulmonary Pressures in Mechanically Ventilated Critically Ill Patients[NCT01969227] | 15 participants (Actual) | Interventional | 2014-01-31 | Completed | |||
| Low-dose Ketamine Versus Morphine for Severe Painful Sickle Cell Crises in Children at Mulago Hospital: A Randomised Controlled Trial[NCT02434939] | Phase 4 | 240 participants (Actual) | Interventional | 2015-06-30 | Completed | ||
| The Effects of Single-dose Rectal Midazolam Application on Post-operative Recovery, Sedation, and Analgesia in Children Given Caudal Anesthesia Plus Bupivacaine[NCT02127489] | Phase 4 | 40 participants (Actual) | Interventional | 2005-06-30 | Completed | ||
| Morphine Versus Ketamine as Adjuvants in Ultrasound-guided Paravertebral Thoracic Blocks in Elective Thoracic Surgery[NCT04852484] | 90 participants (Anticipated) | Interventional | 2021-04-16 | Active, not recruiting | |||
| Fast-track Laparoscopic Surgery. The Effect of Anesthetic Technique[NCT01275911] | 40 participants (Actual) | Interventional | 2009-01-31 | Completed | |||
| Intra-operative Magnesium Sulphate for Post-operative Pain in Patients Undergoing Total Abdominal Hysterectomy Under General Anesthesia[NCT06026527] | Phase 3 | 42 participants (Anticipated) | Interventional | 2023-10-31 | Not yet recruiting | ||
| Effect of Beta Blockade on Opioid-Induced Hyperalgesia in Humans[NCT01222091] | Phase 2 | 10 participants (Actual) | Interventional | 2009-02-28 | Completed | ||
| Ketamine Co-induction for Patients With Major Depressive Disorder; a Randomized Clinical Trial[NCT03666494] | Phase 4 | 50 participants (Anticipated) | Interventional | 2018-12-31 | Not yet recruiting | ||
| Changes of the Short Portable Mental Status Questionnaire (SPMSQ-E) After Ketamine Administration on Ophthalmic Surgery in Geriatric Population.[NCT02049411] | Phase 2 | 80 participants (Actual) | Interventional | 2013-06-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT04129086)
Timeframe: In-hospital days (up to 6 weeks post hospital admission)
| Intervention | MME per day (Mean) |
|---|---|
| Ketamine Plus Usual Care | 32 |
| Usual Care | 39 |
Length of time Ketamine drip was infused (NCT04129086)
Timeframe: Hospital discharge (up to 6 weeks post hospital admission)
| Intervention | hours (Median) |
|---|---|
| Ketamine Plus Usual Care | 60 |
| Usual Care | 76 |
"For this item of the Euro-QOL EQ-5D-3L questionnaire, participants are asked the question How would you rate your health today?, and they respond with a score from 0 - 100, with a higher score indicating a better outcome." (NCT04129086)
Timeframe: 6 months post admission
| Intervention | score on a scale (Median) |
|---|---|
| Ketamine Plus Usual Care | 75 |
| Usual Care | 80 |
"For this item of the Euro-QOL EQ-5D-3L questionnaire, participants are asked the question How would you rate your health today?, and they respond with a score from 0 - 100, with a higher score indicating a better outcome." (NCT04129086)
Timeframe: Hospital discharge (about 1 to 6 weeks after admission)
| Intervention | score on a scale (Median) |
|---|---|
| Ketamine Plus Usual Care | 70 |
| Usual Care | 75 |
"For this item of the Euro-QOL EQ-5D-3L questionnaire, participants are asked the question Have you ever experience this kind of event?, and data are reported as the number of participants who responded yes." (NCT04129086)
Timeframe: 6 months post admission
| Intervention | Participants (Count of Participants) |
|---|---|
| Ketamine Plus Usual Care | 69 |
| Usual Care | 78 |
"For this item of the Euro-QOL EQ-5D-3L questionnaire, participants are asked the question Have you ever experience this kind of event?, and data are reported as the number of participants who responded yes." (NCT04129086)
Timeframe: Hospital discharge (about 1 to 6 weeks after admission)
| Intervention | Participants (Count of Participants) |
|---|---|
| Ketamine Plus Usual Care | 82 |
| Usual Care | 77 |
Number of days patients were not in the hospital during the first 30 days after admission (NCT04129086)
Timeframe: 30 days post admission
| Intervention | days (Median) |
|---|---|
| Ketamine Plus Usual Care | 20 |
| Usual Care | 21 |
Number of inpatient hospital days patients did not require ICU level of care (NCT04129086)
Timeframe: Hospital discharge (up to 6 weeks post hospital admission)
| Intervention | days (Median) |
|---|---|
| Ketamine Plus Usual Care | 29 |
| Usual Care | 28 |
Number of patients requesting to stop Ketamine for any complaint (NCT04129086)
Timeframe: Hospital discharge (up to 6 weeks post hospital admission)
| Intervention | Participants (Count of Participants) |
|---|---|
| Ketamine Plus Usual Care | 9 |
| Usual Care | 0 |
incidence of need for unplanned intubation during in-hospital stay (NCT04129086)
Timeframe: Hospital discharge (up to 6 weeks post hospital admission)
| Intervention | Participants (Count of Participants) |
|---|---|
| Ketamine Plus Usual Care | 2 |
| Usual Care | 3 |
Incidence of delirium during in-hospital stay (NCT04129086)
Timeframe: Hospital discharge (up to 6 weeks post hospital admission)
| Intervention | Participants (Count of Participants) |
|---|---|
| Ketamine Plus Usual Care | 16 |
| Usual Care | 9 |
Number of patients who continue to use opioids (NCT04129086)
Timeframe: 6 months post admission
| Intervention | Participants (Count of Participants) |
|---|---|
| Ketamine Plus Usual Care | 11 |
| Usual Care | 11 |
Number of patients who reported continued pain at 6 months following trauma injury (NCT04129086)
Timeframe: 6 months post admission
| Intervention | Participants (Count of Participants) |
|---|---|
| Ketamine Plus Usual Care | 78 |
| Usual Care | 71 |
Incidence of need for unplanned admission to an ICU (NCT04129086)
Timeframe: Hospital discharge (up to 6 weeks post hospital admission)
| Intervention | Participants (Count of Participants) |
|---|---|
| Ketamine Plus Usual Care | 7 |
| Usual Care | 7 |
DVPRS scores were collected daily. For each participant, an average of the daily scores on the Defense and Veterans Pain Rating Scale was calculated. DVPRS scores range from 0 (no pain) to 10 (as bad as it could be, nothing else matters), with a higher score indicating a worse outcome. (NCT04129086)
Timeframe: From time of admission to time of discharge from hospital (about 1 to 6 weeks after admission)
| Intervention | score on a scale (Median) |
|---|---|
| Ketamine Plus Usual Care | 2.9 |
| Usual Care | 2.5 |
Number of inpatient hospital days patients did not require mechanical ventilation (NCT04129086)
Timeframe: Hospital discharge (up to 6 weeks post hospital admission)
| Intervention | days (Median) |
|---|---|
| Ketamine Plus Usual Care | 30 |
| Usual Care | 30 |
For this item of the Euro-QOL EQ-5D-3L questionnaire, participants are asked to indicate their level of anxiety/depression by choosing a predefined category, and the data for this outcome are reported categorically as the number of participants who chose each category. (NCT04129086)
Timeframe: 6 months post admission
| Intervention | Participants (Count of Participants) | ||||
|---|---|---|---|---|---|
| I am not anxious or depressed | I am slightly anxious or depressed | I am moderately anxious or depressed | I am severely anxious or depressed | I am extremely anxious or depressed | |
| Ketamine Plus Usual Care | 50 | 15 | 11 | 4 | 18 |
| Usual Care | 53 | 19 | 13 | 2 | 15 |
For this item of the Euro-QOL EQ-5D-3L questionnaire, participants are asked to indicate their level of anxiety/depression by choosing a predefined category, and the data for this outcome are reported categorically as the number of participants who chose each category. (NCT04129086)
Timeframe: Hospital discharge (about 1 to 6 weeks after admission)
| Intervention | Participants (Count of Participants) | ||||
|---|---|---|---|---|---|
| I am not anxious or depressed | I am slightly anxious or depressed | I am moderately anxious or depressed | I am severely anxious or depressed | I am extremely anxious or depressed | |
| Ketamine Plus Usual Care | 70 | 24 | 11 | 6 | 13 |
| Usual Care | 74 | 20 | 15 | 7 | 13 |
For this item of the Euro-QOL EQ-5D-3L questionnaire, participants are asked to indicate their level of mobility by choosing a predefined category, and the data for this outcome are reported categorically as the number of participants who chose each category. (NCT04129086)
Timeframe: 6 months post admission
| Intervention | Participants (Count of Participants) | ||||
|---|---|---|---|---|---|
| I have no problems walking | I have slight problems walking | I have moderate problems walking | I have severe problems walking | I am unable to walk | |
| Ketamine Plus Usual Care | 50 | 15 | 12 | 9 | 14 |
| Usual Care | 47 | 21 | 17 | 8 | 9 |
For this item of the Euro-QOL EQ-5D-3L questionnaire, participants are asked to indicate their level of mobility by choosing a predefined category, and the data for this outcome are reported categorically as the number of participants who chose each category. (NCT04129086)
Timeframe: Hospital discharge (about 1 to 6 weeks after admission)
| Intervention | Participants (Count of Participants) | ||||
|---|---|---|---|---|---|
| I have no problems walking | I have slight problems walking | I have moderate problems walking | I have severe problems walking | I am unable to walk | |
| Ketamine Plus Usual Care | 39 | 22 | 15 | 13 | 35 |
| Usual Care | 31 | 20 | 13 | 17 | 48 |
For this item of the Euro-QOL EQ-5D-3L questionnaire, participants are asked to indicate their level of pain/discomfort by choosing a predefined category, and the data for this outcome are reported categorically as the number of participants who chose each category. (NCT04129086)
Timeframe: 6 months post admission
| Intervention | Participants (Count of Participants) | ||||
|---|---|---|---|---|---|
| I have no pain or discomfort | I have slight pain or discomfort | I have moderate pain or discomfort | I have severe pain or discomfort | I have extreme pain or discomfort | |
| Ketamine Plus Usual Care | 31 | 17 | 21 | 10 | 21 |
| Usual Care | 25 | 21 | 24 | 18 | 14 |
For this item of the Euro-QOL EQ-5D-3L questionnaire, participants are asked to indicate their level of pain/discomfort by choosing a predefined category, and the data for this outcome are reported categorically as the number of participants who chose each category. (NCT04129086)
Timeframe: Hospital discharge (about 1 to 6 weeks after admission)
| Intervention | Participants (Count of Participants) | ||||
|---|---|---|---|---|---|
| I have no pain or discomfort | I have slight pain or discomfort | I have moderate pain or discomfort | I have severe pain or discomfort | I have extreme pain or discomfort | |
| Ketamine Plus Usual Care | 25 | 34 | 30 | 21 | 14 |
| Usual Care | 16 | 32 | 39 | 18 | 24 |
For this item of the Euro-QOL EQ-5D-3L questionnaire, participants are asked to indicate their level of mobility by choosing a predefined category, and the data for this outcome are reported categorically as the number of participants who chose each category. (NCT04129086)
Timeframe: 6 months post admission
| Intervention | Participants (Count of Participants) | ||||
|---|---|---|---|---|---|
| I have no problems washing or dressing myself | I have slight problems washing or dressing myself | I have moderate problems washing or dressing myself | I have severe problems washing or dressing myself | I am unable to wash or dress myself | |
| Ketamine Plus Usual Care | 29 | 12 | 16 | 9 | 34 |
| Usual Care | 38 | 10 | 14 | 11 | 28 |
For this item of the Euro-QOL EQ-5D-3L questionnaire, participants are asked to indicate their level of self-care by choosing a predefined category, and the data for this outcome are reported categorically as the number of participants who chose each category. (NCT04129086)
Timeframe: Hospital discharge (about 1 to 6 weeks after admission)
| Intervention | Participants (Count of Participants) | ||||
|---|---|---|---|---|---|
| I have no problems washing or dressing myself | I have slight problems washing or dressing myself | I have moderate problems washing or dressing myself | I have severe problems washing or dressing myself | I am unable to wash or dress myself | |
| Ketamine Plus Usual Care | 42 | 24 | 13 | 5 | 40 |
| Usual Care | 37 | 19 | 15 | 7 | 51 |
For this item of the Euro-QOL EQ-5D-3L questionnaire, participants are asked to indicate their ability to carry out usual activities by choosing a predefined category, and the data for this outcome are reported categorically as the number of participants who chose each category. (NCT04129086)
Timeframe: 6 months post admission
| Intervention | Participants (Count of Participants) | ||||
|---|---|---|---|---|---|
| I have no problems doing my usual activities | I have slight problems doing my usual activities | I have moderate problems doing my usual activities | I have severe problems doing my usual activities | I am unable to do my usual activities | |
| Ketamine Plus Usual Care | 29 | 12 | 16 | 9 | 34 |
| Usual Care | 38 | 10 | 14 | 11 | 28 |
For this item of the Euro-QOL EQ-5D-3L questionnaire, participants are asked to indicate their ability to carry out usual activities by choosing a predefined category, and the data for this outcome are reported categorically as the number of participants who chose each category. (NCT04129086)
Timeframe: Hospital discharge (about 1 to 6 weeks after admission)
| Intervention | Participants (Count of Participants) | ||||
|---|---|---|---|---|---|
| I have no problems doing my usual activities | I have slight problems doing my usual activities | I have moderate problems doing my usual activities | I have severe problems doing my usual activities | I am unable to do my usual activities | |
| Ketamine Plus Usual Care | 17 | 8 | 5 | 2 | 92 |
| Usual Care | 7 | 10 | 9 | 4 | 99 |
Number of patients discharged from the hospital with an opioid prescription (NCT04129086)
Timeframe: Hospital discharge (up to 6 weeks post hospital admission)
| Intervention | Participants (Count of Participants) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Any Opioid at discharge | Tramadol | Hydrocodone | Oxycodone | Codeine | Methadone | Fentanyl patch | Hydromorphone | Morphine | |
| Ketamine Plus Usual Care | 82 | 72 | 3 | 10 | 1 | 0 | 0 | 0 | 1 |
| Usual Care | 97 | 81 | 2 | 15 | 3 | 0 | 0 | 0 | 0 |
"The PC-PTSD-5 questionnaire asks the below 5 questions, and data are reported categorically as the number of participants who responded yes to each of the 5 questions. An answer of yes is indicative of a PTSD symptom, which is a worse outcome.~In the past month, have you had nightmares about the events or thought about the events when you did not want to?~In the past month, have you tried hard not to think about the events or went out of your way to avoid situations that reminded you of the events?~In the past month, have you been constantly on guard, watchful, or easily startled?~In the past month, have you felt numb or detached from people, activities, or your surroundings?~In the past month, have you felt guilty or unable to stop blaming yourself or others for the events or any problems the events may have caused?" (NCT04129086)
Timeframe: 6 months post admission
| Intervention | Participants (Count of Participants) | ||||
|---|---|---|---|---|---|
| 1. had nightmares about the events or thought about the events when you did not want to | 2. tried hard not to think about the events or went out of your way to avoid situations | 3. been constantly on guard, watchful, or easily startled | 4. felt numb or detached from people, activities, or your surrounding | 5. felt guilty or unable to stop blaming yourself or others | |
| Ketamine Plus Usual Care | 24 | 41 | 42 | 37 | 24 |
| Usual Care | 19 | 44 | 47 | 36 | 23 |
"The PC-PTSD-5 questionnaire asks the below 5 questions, and data are reported categorically as the number of participants who responded yes to each of the 5 questions. An answer of yes is indicative of a PTSD symptom, which is a worse outcome.~In the past month, have you had nightmares about the events or thought about the events when you did not want to?~In the past month, have you tried hard not to think about the events or went out of your way to avoid situations that reminded you of the events?~In the past month, have you been constantly on guard, watchful, or easily startled?~In the past month, have you felt numb or detached from people, activities, or your surroundings?~In the past month, have you felt guilty or unable to stop blaming yourself or others for the events or any problems the events may have caused?" (NCT04129086)
Timeframe: Hospital discharge (about 1 to 6 weeks after admission)
| Intervention | Participants (Count of Participants) | ||||
|---|---|---|---|---|---|
| 1. had nightmares about the events or thought about the events when you did not want to | 2. tried hard not to think about the events or went out of your way to avoid situations | 3. been constantly on guard, watchful, or easily startled | 4. felt numb or detached from people, activities, or your surrounding | 5. felt guilty or unable to stop blaming yourself or others | |
| Ketamine Plus Usual Care | 30 | 35 | 36 | 24 | 19 |
| Usual Care | 18 | 49 | 43 | 31 | 25 |
Total ORT score ranges from 0 to 26. A score of 3 or lower indicates low risk for future opioid abuse, a score of 4 to 7 indicates moderate risk for opioid abuse, and a score of 8 or higher indicates a high risk for opioid abuse. (NCT04129086)
Timeframe: Hospital discharge (about 1 to 6 weeks after admission)
| Intervention | Participants (Count of Participants) | ||
|---|---|---|---|
| Low risk of future opioid abuse (score of 0-3) | Moderate risk of future opioid abuse (score of 4-7) | High risk of future opioid abuse (score of 8 or higher) | |
| Ketamine Plus Usual Care | 92 | 13 | 19 |
| Usual Care | 94 | 25 | 10 |
Incidence of use of additional pain control adjuncts such as regional anesthesia and lidocaine patch during hospitalization (NCT04129086)
Timeframe: Hospital discharge (up to 6 weeks post hospital admission)
| Intervention | Participants (Count of Participants) | |
|---|---|---|
| Regional anesthesia | Lidocaine drip | |
| Ketamine Plus Usual Care | 16 | 0 |
| Usual Care | 20 | 0 |
Behavioral Pain Scale, on a scale ranging from 3 to 12 when 3 is no pain and 12 is maximum pain (NCT03577730)
Timeframe: Data gathered from postoperative day 0-3. Final results were based on all values combined over this time period, per protocol.
| Intervention | score on a scale (Median) |
|---|---|
| Experimental | 3 |
| Control | 3 |
Visual Analogue Scale (mm, 0-100, 0 = no pain, 100 = worst pain imaginable) (NCT03577730)
Timeframe: Data gathered from postoperative day 0-3. Final results were based on all values combined over this time period, per protocol.
| Intervention | score on a scale (Median) |
|---|---|
| Experimental | 40 |
| Control | 39 |
Trail Making Test scores (seconds, 10-300,10 = fastest reported completion, 300 = maximum time allowed for completion). The change was calculated from the value at post anesthesia minus value at baseline. Higher values are considered to be worse outcomes. (NCT03577730)
Timeframe: morning of surgery baseline compared to postanesthesia care unit. Postanesthesia care unit measurement approximately 60 minutes after end of surgery
| Intervention | score on a scale (Median) |
|---|---|
| Experimental | 10 |
| Control | 16 |
Postoperative opioid consumption, oral morphine equivalents (mg) (NCT03577730)
Timeframe: through postoperative day 3
| Intervention | oral morphine equivalents (mg) (Median) |
|---|---|
| Experimental | 77 |
| Control | 51 |
Negative Affect Score (n, 10-50, 10 = least negative affect, 50 = most negative affect) via PANAS (Positive and Negative Affect Schedule) (NCT03577730)
Timeframe: postoperative day 3
| Intervention | score on a scale (Median) |
|---|---|
| Experimental | 12 |
| Control | 12 |
Number (n) of participants with positive screens (score ≥8) using the Hospitalized Anxiety and Depression Scale (HADS-A) (n, 0-21, 0 = normal, 21 = presence of severe anxiety symptoms) (NCT03577730)
Timeframe: baseline through postoperative day 3
| Intervention | Participants (Count of Participants) |
|---|---|
| Experimental | 2 |
| Control | 2 |
Number (n) of participants with positive screens (score ≥8) using the Hospitalized Anxiety and Depression Scale (HADS-D) (n, 0-21, 0 = normal, 21 = presence of severe depression symptoms) (NCT03577730)
Timeframe: baseline through postoperative day 3
| Intervention | Participants (Count of Participants) |
|---|---|
| Experimental | 2 |
| Control | 1 |
Number (n) of participants who has experienced at least one episode of delirium by the postoperative day 3 time point, as determined by daily Confusion Assessment Method (CAM). (NCT03577730)
Timeframe: By afternoon of postoperative day (POD) 3
| Intervention | Participants (Count of Participants) |
|---|---|
| Experimental | 7 |
| Control | 14 |
Positive Affect Score (n, 10-50, 10 = least positive affect, 50 = most positive affect) via PANAS (Positive and Negative Affect Schedule) (NCT03577730)
Timeframe: postoperative day 3
| Intervention | score on a scale (Median) |
|---|---|
| Experimental | 35 |
| Control | 35 |
Self-report instrument for measuring sleep quality. Visual Analogue Scale (mm, 0-100, 0 =Deep sleep , 100 =Light sleep) (NCT03577730)
Timeframe: Preoperative (once before surgery on day of surgery)
| Intervention | score on a scale (Mean) |
|---|---|
| Experimental | 58 |
| Control | 56 |
Time from surgical dressing on to anesthetic emergence (min) (NCT03577730)
Timeframe: Duration of time from surgical dressing completion to anesthetic emergence (min); generally expected to be between 10 and 60 minutes
| Intervention | Minutes (Median) |
|---|---|
| Experimental | 8 |
| Control | 10 |
Assessed via Confusion Assessment Method or Confusion Assessment Method for Intensive Care Unit (NCT01690988)
Timeframe: Postoperative days 1-3
| Intervention | Participants (Count of Participants) |
|---|---|
| Ketamine (0.5 mg/kg) | 45 |
| Normal Saline (Placebo) | 40 |
| Ketamine (1 mg/kg) | 62 |
Assessed via Confusion Assessment Method or Confusion Assessment Method for Intensive care Unit (NCT01690988)
Timeframe: Postoperative days 1-3
| Intervention | Participants (Count of Participants) |
|---|---|
| Ketamine (0.5 mg/kg) | 27 |
| Normal Saline (Placebo) | 18 |
| Ketamine (1 mg/kg) | 34 |
"Assessed from patients' medical charts. All morphine equivalent drugs consumed by patients perioperatively~Opioid Drugs included:~* Postoperatively while still in hospital, the list of pain medication used included Morphine, Hydromorphone, Meperidine, Nalbuphine, Oxycodone,Oxymorphone, Tramadol, bupivacaine, (Codeine, Fentanyl, Naloxone) Total Opiates (Morphine Equivalent) in milligrams The median(IQR) opioid consumption was compared across the three study groups Placebo vs. Lo-K (0.5 mg/kg) vs. Hi-K (1 mg/kg)" (NCT01690988)
Timeframe: Postoperative days 0-3
| Intervention | mg (Median) |
|---|---|
| Ketamine (0.5 mg/kg) | 88.9 |
| Normal Saline (Placebo) | 94.7 |
| Ketamine (1 mg/kg) | 78.7 |
"According to Confusion Assessment Method or Confusion Assessment Method for Intensive Care Unit criteria the number of patients that had any positive CAM on any day for all patients. The main effect evaluated will be to determine whether ketamine decreases delirium, table 3 of the protocol provides a useful guide for the potential findings of the current study with their implications.~To further clarify, delirium will be assessed on the day of surgery, when possible and on the subsequent three days POD 1-3, as long as as patients remain in the hospital and are assessable (i.e., not sedated to a RASS <-3). The assessments on POD 1-3 will be done twice daily, once in the morning and once in the afternoon. The primary outcome of the study includes only the delirium incidence on POD 1-3.~The primary comparison will be between the combined ketamine groups and the placebo group." (NCT01690988)
Timeframe: Delirium incidence on postoperative days 1-3, calculated by any positive CAM on any day for all patients
| Intervention | Participants (Count of Participants) |
|---|---|
| Ketamine (0.5 mg/kg and 1 mg/kg) | 85 |
| Normal Saline (Placebo) | 43 |
"Assessed from patient-reported postoperative nausea and vomiting section of Behavioral Pain Scale or Behavioral Pain Scale (Non-Intubated) Patients where asked whether they currently have nausea/vomiting AM & PM the response choices: None, Mild, Moderate, Severe Incidence of nauseavomiting accounted for any positive reporting(Mild, moderate, or sever) Daily incidence accounted for any positive incidence AM/PM in each POD Any POD nausea/vomiting reports the incidence across day 1-3~The incidence of nausea and or vomiting was compared across the three study groups Placebo vs. Lo-K (0.5 mg/kg) vs. Hi-K (1 mg/kg) for POD 1-3 and overall." (NCT01690988)
Timeframe: Postoperative days 1-3
| Intervention | Participants (Count of Participants) |
|---|---|
| Ketamine (0.5 mg/kg) | 72 |
| Normal Saline (Placebo) | 73 |
| Ketamine (1 mg/kg) | 64 |
Assessed by observer-based Behavioral Pain Scale or Behavioral Pain Scale (Non-Intubated) with subsequent administration of patient-reported Visual Analog Scale The behavioral pain scale has three domains and ranges from 3 to 15. The visual analog scale is a continuous scale from 0 to 100 mm. Daily Maximum Pain accounted for pain level in the AM or PM for both the VAS and the BPS/BPS-NI a higher value means a worse outcome. (NCT01690988)
Timeframe: Postoperative days 1-3, two assessment daily (morning and afternoon), with at least six hours between assessments
| Intervention | participants (Median) | |||||
|---|---|---|---|---|---|---|
| VAS day 1 | VAS day 2 | VAS day 3 | BPS/BPS-NI day 1 | BPS/BPS-NI 2 | BPS/BPS-NI 3 | |
| Ketamine (0.5 mg/kg ) | 70 | 56 | 46 | 4 | 4 | 3 |
| Ketamine (1 mg/kg) | 68 | 57.5 | 47 | 4 | 3 | 3 |
| Normal Saline (Placebo) | 63.5 | 59 | 52.5 | 4 | 3 | 3 |
Pain will be measured using an 11-point numerical rating scale from 0 (no pain) to 10 (worst pain imaginable) units on a scale. (NCT02514122)
Timeframe: The average of twice daily pain scores, from end of surgery until 60 hours postoperative.
| Intervention | units on a scale (Mean) |
|---|---|
| Ketamine | 3.5 |
| Saline | 4.9 |
VAS Scores will be assessed on Day of Surgery (DOS), Post-op Day (POD) 1, 2 and 7. If patients have been discharged, coordinators will contact patient by home. (NCT02452060)
Timeframe: Baseline (DOS) to 7 days (Post Op)
| Intervention | score on a scale (Mean) |
|---|---|
| Treatment/Placebo | 1.45 |
| Treatment | 1 |
LOS will be recorded from medical record. (NCT02452060)
Timeframe: 8 days
| Intervention | Days (Median) |
|---|---|
| Treatment/Placebo | 1.3 |
| Treatment | 1.2 |
Hydromorphone use during the first postoperative 24 hours in mg/kg (NCT03274453)
Timeframe: 24 Hours
| Intervention | mg/kg (Mean) |
|---|---|
| Naive Placebo | .13 |
| Naive Ketamine | .09 |
| Tolerant Placebo | .27 |
| Tolerant Ketamine | .19 |
The presence of lightheaded recorded at the above time points (NCT01296347)
Timeframe: 108 hours
| Intervention | Participants (Count of Participants) |
|---|---|
| Saline | 5 |
| Ketamine | 14 |
The presence of vivid dreams recorded at the above time points (NCT01296347)
Timeframe: 108 hours
| Intervention | Participants (Count of Participants) |
|---|---|
| Saline | 2 |
| Ketamine | 13 |
The presence of vomiting recorded at the above time points (NCT01296347)
Timeframe: 108 hours
| Intervention | Participants (Count of Participants) |
|---|---|
| Saline | 8 |
| Ketamine | 8 |
The presence of nausea recorded at the above time points (NCT01296347)
Timeframe: 108 hours
| Intervention | Participants (Count of Participants) |
|---|---|
| Saline | 14 |
| Ketamine | 17 |
"Measures in pain include:~Numeric pain score of 0 to 10. Zero denotes 'no pain'; 10 denotes 'pain as bad as you can imagine'" (NCT01296347)
Timeframe: 6 weeks after surgery
| Intervention | units on a scale (Median) |
|---|---|
| Saline | 0 |
| Ketamine | 1.5 |
Analgesia consumption will be measured post-operatively and at 6 weeks (NCT01296347)
Timeframe: 6 weeks, 3 month, 6 month
| Intervention | mg (Median) | ||
|---|---|---|---|
| 6 weeks | 3 months | 6 months | |
| Ketamine | 0 | 17 | 9 |
| Saline | 9 | 21 | 34 |
The Montgomery-Asberg Depression Rating Scale (MADRS) is a 10-item scale that measures the severity of depression, with a higher score indicating a higher level of depression. The range of scores is 0 to 60. (NCT01179009)
Timeframe: 8 weeks
| Intervention | Scores on a scale (Mean) |
|---|---|
| Ketamine 100-hour Infusion | -9.0 |
| Ketamine 40-minute Infusion | -6.4 |
Reduction in 100 mm Visual Analog Scale (VAS) Score. The maximum possible change in VAS score is 100 mm, representing the complete relief of maximum anxiety. A change of 0 mm corresponds to no change in anxiety level, and a negative value indicates worsening of the anxiety after the medication. (NCT02657031)
Timeframe: 0-60 minutes
| Intervention | mm (Mean) |
|---|---|
| Control Arm | 33.7 |
| Study Arm | 21.2 |
Reduction in 100 mm Visual Analog Scale (VAS) Score. Positive values represent a reduction in headache severity. The maximum possible change in VAS score is 100 mm, representing the complete relief of a maximally severe headache. A change of 0 mm corresponds to no change in headache severity, and a negative value indicates worsening of the headache after the medication. (NCT02657031)
Timeframe: 0-60 minutes
| Intervention | mm (Mean) |
|---|---|
| Control Arm | 63.5 |
| Study Arm | 43.5 |
Reduction in 100 mm Visual Analog Scale (VAS) Score. The maximum possible change in VAS score is 100 mm, representing the complete relief of maximum nausea. A change of 0 mm corresponds to no change in nausea level, and a negative value indicates worsening of the nausea after the medication. (NCT02657031)
Timeframe: 0-60 minutes
| Intervention | mm (Mean) |
|---|---|
| Control Arm | 38.9 |
| Study Arm | 22.9 |
Yes/No (NCT02657031)
Timeframe: 0-60 minutes
| Intervention | participants (Number) |
|---|---|
| Control Arm | 2 |
| Study Arm | 3 |
Yes/No (NCT02657031)
Timeframe: 0-60 minutes
| Intervention | participants (Number) |
|---|---|
| Control Arm | 3 |
| Study Arm | 3 |
American Shoulder and Elbow Surgeons (ASES) Shoulder Score for pain and function. Range 0-100. Low score = worse shoulder condition. Function, disability, and pain subscores (all ranges 0-50), and are summed for total ASES score. (NCT03540030)
Timeframe: 2 Weeks
| Intervention | units on a scale (Median) |
|---|---|
| Observational | 54.3 |
| Non-Opioid Intervention | 54.2 |
Morphine milli-equivalents In-hospital post-operative. Continuous scale of MME, no defined better/worse. Measured as number and dose of medications taken. For example, if the patient received an opioid, the drug and dose was recorded and converted to MME. A time frame of when to assess opioid use in-hospital post-operative was not used but was a continuous monitor for rescue opioid from in-hospital post-operative through discharge. (NCT03540030)
Timeframe: In-hospital Stay
| Intervention | Morphine milli-equivalents (Median) |
|---|---|
| Observational | 45.0 |
| Non-Opioid Intervention | 19.0 |
Pain at patient discharge or 24-hours, whichever comes first - measured on a 0 (no pain) -10 (worst possible pain) numeric rating scale (NRS). A score of 0(no pain) is preferable to 10(worst possible pain) (NCT03540030)
Timeframe: 24 hours
| Intervention | score on a scale (Median) |
|---|---|
| Observational | 3.0 |
| Non-Opioid Intervention | 2.0 |
Simple Shoulder Test (SST) activity score. Range 0-12. 0 = worse activity score. (NCT03540030)
Timeframe: 2 Months
| Intervention | score on a scale (Median) |
|---|---|
| Observational | 6 |
| Non-Opioid Intervention | 6 |
Simple Shoulder Test (SST) activity score. Range 0-12. 0 = worse activity score. (NCT03540030)
Timeframe: 2 Weeks
| Intervention | score on a scale (Median) |
|---|---|
| Observational | 2.0 |
| Non-Opioid Intervention | 2.0 |
post-operative pain: measured on a 0 (no pain) -10 (worst) numeric rating scale (NRS) at 6hrs, 12hrs, 2 weeks, and 2 months. A score of 0(no pain) is preferable to 10(worst possible pain) (NCT03540030)
Timeframe: 6hrs, 12hrs, 2weeks, 2 months
| Intervention | score on a scale (Median) | |||
|---|---|---|---|---|
| 6 Hrs | 12 hrs | 2 weeks | 2 months | |
| Non-Opioid Intervention | 0.0 | 0 | 0.82 | 0 |
| Observational | 2 | 4 | 1.3 | 0.7 |
rate of constipation (NCT03540030)
Timeframe: 2 Months
| Intervention | Participants (Count of Participants) | ||
|---|---|---|---|
| Yes | No | Unknown | |
| Non-Opioid Intervention | 4 | 27 | 4 |
| Observational | 7 | 21 | 2 |
rate of constipation (NCT03540030)
Timeframe: 2 Weeks
| Intervention | Participants (Count of Participants) | ||
|---|---|---|---|
| Yes | No | Unknown | |
| Non-Opioid Intervention | 13 | 22 | 0 |
| Observational | 19 | 9 | 2 |
rate of falls (NCT03540030)
Timeframe: 2 Months
| Intervention | Participants (Count of Participants) | ||
|---|---|---|---|
| Yes | No | Unknown | |
| Non-Opioid Intervention | 4 | 27 | 4 |
| Observational | 4 | 24 | 2 |
rate of falls (NCT03540030)
Timeframe: 2 Weeks
| Intervention | Participants (Count of Participants) | ||
|---|---|---|---|
| Yes | No | Unknown | |
| Non-Opioid Intervention | 5 | 30 | 0 |
| Observational | 1 | 27 | 2 |
rate of nausea (NCT03540030)
Timeframe: 2 Months
| Intervention | Participants (Count of Participants) | ||
|---|---|---|---|
| Yes | No | Unknown | |
| Non-Opioid Intervention | 1 | 30 | 0 |
| Observational | 0 | 28 | 2 |
rate of nausea (NCT03540030)
Timeframe: 2 Weeks
| Intervention | Participants (Count of Participants) | ||
|---|---|---|---|
| Yes | No | Unknown | |
| Non-Opioid Intervention | 1 | 34 | 0 |
| Observational | 5 | 23 | 2 |
Satisfaction with overall pain using Numeric Pain Rating (NRS) scale. yes, no. No being better than yes. (NCT03540030)
Timeframe: 2 Months
| Intervention | Participants (Count of Participants) | ||
|---|---|---|---|
| Yes | No | Unknown | |
| Non-Opioid Intervention | 29 | 2 | 4 |
| Observational | 23 | 5 | 2 |
Satisfaction with overall pain using Numeric Pain Rating (NRS) scale. yes, no. No being better than yes. (NCT03540030)
Timeframe: 2 Weeks
| Intervention | Participants (Count of Participants) | ||
|---|---|---|---|
| Yes | No | Unknown | |
| Non-Opioid Intervention | 34 | 1 | 0 |
| Observational | 27 | 1 | 2 |
quality of life using VR-12 subscores. Physical Health (PCS) subscore and Mental Health (MCS) subscore, not summed. Range reported in weighted units. Physical Health subscore: 1 point increase in PCS is associated with 6% lower total health care expenditures, 5% lower pharmacy expenditures, 9% lower rate of hospital inpatient visits, 4% lower rate of medical provider visits, 5% lower rate of hospital outpatient visits. Mental Health sub score a 1 point increase in MCS is associated with 7% lower total health care expenditures, 4% lower pharmacy expenditures, 15% lower rate of hospital inpatient visits, and 4% lower rate of medical provider visits. Both PCS/MCS are score 0-100 with 100 indicating the highest level of health. (NCT03540030)
Timeframe: 2 Months
| Intervention | score on a scale (Median) | |
|---|---|---|
| PCS | MCS | |
| Non-Opioid Intervention | 40.3 | 60.8 |
| Observational | 38.4 | 58.7 |
quality of life using VR-12 subscores. Physical Health (PCS) subscore and Mental Health (MCS) subscore, not summed. Range reported in weighted units. Physical Health subscore: 1 point increase in PCS is associated with 6% lower total health care expenditures, 5% lower pharmacy expenditures, 9% lower rate of hospital inpatient visits, 4% lower rate of medical provider visits, 5% lower rate of hospital outpatient visits. Mental Health sub score a 1 point increase in MCS is associated with 7% lower total health care expenditures, 4% lower pharmacy expenditures, 15% lower rate of hospital inpatient visits, and 4% lower rate of medical provider visits. Both PCS/MCS are score 0-100 with 100 indicating the highest level of health. (NCT03540030)
Timeframe: 2 Weeks
| Intervention | score on a scale (Median) | |
|---|---|---|
| PCS | MCS | |
| Non-Opioid Intervention | 35.0 | 59.1 |
| Observational | 36.7 | 56.3 |
Morphine consumption (mg/kg) was measured over time in the Ketamine group and compared to the Control (saline) group. Values are for each 24 hour time period and displayed as hours post surgery. (NCT01325493)
Timeframe: at 24, 48, 72, 96 hours post operatively
| Intervention | mg/kg (Mean) | |||
|---|---|---|---|---|
| 24 hrs after surgery | 48 hrs after surgery | 72 hrs after surgery | 96 hrs after surgery | |
| Ketamine | 1.3 | 1.28 | .89 | .57 |
| Saline | 1.36 | 1.275 | .93 | .38 |
Patient volunteered response at rest, 1-10 scale (where a higher score indicates more pain and a lower score indicates less pain). Values are for each 24 hour time period and displayed as hours post surgery. (NCT01325493)
Timeframe: 24, 48, 72, 96 hours post operatively
| Intervention | pain score at rest (Mean) | |||
|---|---|---|---|---|
| 24 hrs after surgery | 48 hrs after surgery | 72 hrs after surgery | 96 hrs after surgery | |
| Ketamine | 3.9 | 4.53 | 3.6 | 4.48 |
| Saline | 4.55 | 5.2 | 3.48 | 3.8 |
Patient volunteered response during a cough, 1-10 scale (where a higher score indicates more pain and a lower score indicates less pain). Values are for each 24 hour time period and displayed as hours post surgery. (NCT01325493)
Timeframe: 24, 48, 72, 96 hours post operatively
| Intervention | pain score at cough (Mean) | |||
|---|---|---|---|---|
| 24 hrs after surgery | 48 hrs after surgery | 72 hrs after surgery | 96 hrs after surgery | |
| Ketamine | 4.5 | 5.4 | 4.4 | 5.15 |
| Saline | 5.1 | 5.45 | 3.7 | 4.2 |
"Sedation scores 0 = completely awake~= sleepy but responds appropriately~= somnolent but arouses to light stimuli~= asleep but responsive to deeper physical stimuli~= asleep and not responsive to any stimuli Values are for each 24 hour time period and displayed as hours post surgery." (NCT01325493)
Timeframe: 24, 48, 72, 96 hours post operatively
| Intervention | Sedation Score (Mean) | |||
|---|---|---|---|---|
| 24 hrs after surgery | 48 hrs after surgery | 72 hrs after surgery | 96 hrs after surgery | |
| Ketamine | .73 | .62 | .38 | .24 |
| Saline | .75 | .54 | .3 | .21 |
"Beck's Depression Inventory (BDI) is a 21-item, self-report rating inventory that measures attitudes and symptoms of depression. Each sentence has a rating from 0 to 3 and the sentences go from mild to fairly severe descriptions of moods. The numbers are tabulated, the lowest possible score is 0 and the highest is 63.~A score of 1-10 indicates normal ups and downs. 11-16 indicates a mild mood disturbance; 17-20, borderline clinical depression; 21-30, moderate depression; 31-40, severe depression; over 40, extreme depression" (NCT02424591)
Timeframe: Post-op Day 3
| Intervention | points (Median) |
|---|---|
| Ketamine | 8 |
| Placebo | 9 |
"McGill Short Form measures pain in different ways. The first part of the form lists 15 adjectives for pain, for which the answers can be none (0), Mild (1), Moderate (2) and Severe (3). Descriptors 1-11 represent the sensory dimension of pain experience and 12-15 represent the affective dimension. A score of 0 is good, and a score of 45 indicates extreme pain. The lower the score the less pain a subject feels (better), as the scores go up, so do the pain levels (worse).~PPI (Present Pain Intensity) asks patients to measure pain from 0 (no pain) to 5 (excruciating). Again, a lower score is ideal." (NCT02424591)
Timeframe: Post-op Day 3
| Intervention | points (Median) |
|---|---|
| Ketamine | 11 |
| Placebo | 10.5 |
Quality of Recovery 15 questions questionnaires that ask, on a scale of 0-10, with 0 always being bad and 10 always being best, how the patient is recovering. The total number is reviewed, so the highest total score possible is 150 and the lowest is 0. (NCT02424591)
Timeframe: Post-op Day 3
| Intervention | points (Median) |
|---|---|
| Ketamine | 95 |
| Placebo | 101 |
The evaluations using the soft brush were performed 2-3 cm from the incision in the periumbilical region (where the large trocar was placed) 24 h after the procedure (NCT01301079)
Timeframe: 24 h after the procedure
| Intervention | participants (Number) |
|---|---|
| Ketamine | 1 |
| Saline | 0 |
The evaluations using the soft brush were performed 2-3 cm from the incision in the periumbilical region (where the large trocar was placed) before the procedure (NCT01301079)
Timeframe: Before the procedure (Baseline)
| Intervention | participants (Number) |
|---|---|
| Ketamine | 1 |
| Saline | 0 |
The evaluations using the soft brush were performed in the thenar eminence of the non dominant hand 24 h after the procedure (NCT01301079)
Timeframe: 24 h after the procedure
| Intervention | participants (Number) |
|---|---|
| Ketamine | 1 |
| Saline | 3 |
The evaluations using the soft brush were performed in the thenar eminence of the nondominant hand before the procedure (NCT01301079)
Timeframe: Before the procedure (Baseline)
| Intervention | participants (Number) |
|---|---|
| Ketamine | 1 |
| Saline | 0 |
The 300-g filament was used 24 hours after the operation to induce a stimulus and delineate the extent of hyperalgesia from the periumbilical region. The stimulus was started outside the periumbilical region, where no pain sensation was reported, and continued every 0.5 cm until the 4 points of the periumbilical scar were reached (top, right side, left side, and bottom). The first point where the patient complained of pain was marked. If no pain sensation was reported, the stimulus was terminated 0.5 cm from the incision. The distance of each point from the surgical incision was measured, and the sum of the distances of the points was determined. (NCT01301079)
Timeframe: 24 hours after the procedure
| Intervention | centimeter (Mean) |
|---|---|
| Ketamine | 10.61 |
| Saline | 11.82 |
The mechanical pain threshold was evaluated using an algometer. The pressure was increased by 0.1 kgf/second until the patient complained of pain. The mean of three determinations was calculated. (NCT01301079)
Timeframe: 24 h after the procedure
| Intervention | kilogram force/second (Mean) |
|---|---|
| Ketamine | 3.5 |
| Saline | 3.7 |
The mechanical pain threshold was evaluated using an algometer. The pressure was increased by 0.1 kgf/second until the patient complained of pain. The mean of three determinations was calculated. (NCT01301079)
Timeframe: 24 h after the procedure
| Intervention | kilogram force/second (Mean) |
|---|---|
| Ketamine | 0.56 |
| Saline | 0.51 |
The pain threshold was assessed using six von Frey monofilaments (0,05 g; 0,2 g; 2 g; 4 g; 10 g e 300 g) in the periumbilical region in the postoperative period (24h after the procedure). The use of different von Frey monofilaments, starting with the lightest and ending with the heaviest, was separated by at least 30 seconds to reduce any anticipated responses due to a new stimulation that was performed too soon after the preceding stimulation. Three assessments were made for each monofilament, and this was considered positive when the patient responded to two of the determinations for each monofilament. (NCT01301079)
Timeframe: 24h after the procedure
| Intervention | gram (Mean) |
|---|---|
| Ketamine | 248 |
| Saline | 205 |
The pain threshold was assessed using six von Frey monofilaments (0,05 g; 0,2 g; 2 g; 4 g; 10 g e 300 g) in thenar eminence in the postoperative period (24 hours after procedure). The use of different von Frey monofilaments, starting with the lightest and ending with the heaviest, was separated by at least 30 seconds to reduce any anticipated responses due to a new stimulation that was performed too soon after the preceding stimulation. Three assessments were made for each monofilament, and this was considered positive when the patient responded to two of the determinations for each monofilament. (NCT01301079)
Timeframe: 24 hours after procedure
| Intervention | gram (Mean) |
|---|---|
| Ketamine | 290 |
| Saline | 247 |
The mechanical pain threshold was evaluated using an algometer. The pressure was increased by 0.1 kgf/second until the patient complained of pain. The mean of three determinations was calculated. (NCT01301079)
Timeframe: Baseline (before the surgery)
| Intervention | kilogram force/second (Mean) |
|---|---|
| Ketamine | 3.6 |
| Saline | 3.9 |
The mechanical pain threshold was evaluated using an algometer. The pressure was increased by 0.1 kgf/second until the patient complained of pain. The mean of three determinations was calculated. (NCT01301079)
Timeframe: Baseline (before the procedure)
| Intervention | kilogram force/second (Mean) |
|---|---|
| Ketamine | 2.51 |
| Saline | 2.19 |
The pain threshold was assessed using six von Frey monofilaments (0,05 g; 0,2 g; 2 g; 4 g; 10 g e 300 g) in the periumbilical region in the preoperative period. The use of different von Frey monofilaments, starting with the lightest and ending with the heaviest, was separated by at least 30 seconds to reduce any anticipated responses due to a new stimulation that was performed too soon after the preceding stimulation. Three assessments were made for each monofilament, and this was considered positive when the patient responded to two of the determinations for each monofilament. (NCT01301079)
Timeframe: Before the procedure (Baseline)
| Intervention | gram (Mean) |
|---|---|
| Ketamine | 279 |
| Saline | 269 |
The pain threshold was assessed using six von Frey monofilaments (0,05 g; 0,2 g; 2 g; 4 g; 10 g e 300 g) in thenar eminence in the preoperative period. The use of different von Frey monofilaments, starting with the lightest and ending with the heaviest, was separated by at least 30 seconds to reduce any anticipated responses due to a new stimulation that was performed too soon after the preceding stimulation. Three assessments were made for each monofilament, and this was considered positive when the patient responded to two of the determinations for each monofilament. (NCT01301079)
Timeframe: Before the procedure (Baseline)
| Intervention | gram (Mean) |
|---|---|
| Ketamine | 300 |
| Saline | 300 |
(NCT01301079)
Timeframe: 24 hours
| Intervention | milligram (Mean) |
|---|---|
| Ketamine | 27.40 |
| Saline | 27.70 |
The scale measure pain after 12 hours (0 - without pain and 10 worst pain possible). The individual can choose any number between 0 - 10. (NCT01301079)
Timeframe: 12 hours
| Intervention | units on a scale (Mean) |
|---|---|
| Ketamine | 1.6 |
| Saline | 1.4 |
The scale measure pain after 120 minutes (0 - without pain and 10 worst pain possible). The individual can choose any number between 0 - 10. (NCT01301079)
Timeframe: 120 minutes
| Intervention | units on a scale (Mean) |
|---|---|
| Ketamine | 2.2 |
| Saline | 2.0 |
The scale measure pain after 150 minutes (0 - without pain and 10 worst pain possible). The individual can choose any number between 0 - 10. (NCT01301079)
Timeframe: 150 minutes
| Intervention | units on a scale (Mean) |
|---|---|
| Ketamine | 1.4 |
| Saline | 1.4 |
The scale measure pain after 18 hours (0 - without pain and 10 worst pain possible). The individual can choose any number between 0 - 10. (NCT01301079)
Timeframe: 18 hours
| Intervention | units on a scale (Mean) |
|---|---|
| Ketamine | 1.5 |
| Saline | 1.3 |
The scale measure pain after 180 minutes (0 - without pain and 10 worst pain possible). The individual can choose any number between 0 - 10. (NCT01301079)
Timeframe: 180 minutes
| Intervention | units on a scale (Mean) |
|---|---|
| Ketamine | 1.1 |
| Saline | 1.3 |
The scale measure pain after 210 minutes (0 - without pain and 10 worst pain possible). The individual can choose any number between 0 - 10. (NCT01301079)
Timeframe: 210 minutes
| Intervention | units on a scale (Mean) |
|---|---|
| Ketamine | 0.9 |
| Saline | 1.2 |
The scale measure pain after 24 hours (0 - without pain and 10 worst pain possible). The individual can choose any number between 0 - 10. (NCT01301079)
Timeframe: 24 hours
| Intervention | units on a scale (Mean) |
|---|---|
| Ketamine | 1.4 |
| Saline | 0.8 |
The scale measure pain after 240 minutes (0 - without pain and 10 worst pain possible). The individual can choose any number between 0 - 10. (NCT01301079)
Timeframe: 240 minutes
| Intervention | units on a scale (Mean) |
|---|---|
| Ketamine | 1.0 |
| Saline | 1.1 |
The scale measure pain after 30 minutes (0 - without pain and 10 worst pain possible). The individual can choose any number between 0 - 10. (NCT01301079)
Timeframe: 30 minutes
| Intervention | units on a scale (Mean) |
|---|---|
| Ketamine | 5.5 |
| Saline | 6.2 |
The scale measure pain after 6 hours (0 - without pain and 10 worst pain possible). The individual can choose any number between 0 - 10. (NCT01301079)
Timeframe: 6 hours
| Intervention | units on a scale (Mean) |
|---|---|
| Ketamine | 0.9 |
| Saline | 0.7 |
The scale measure pain after 60 minutes (0 - without pain and 10 worst pain possible). The individual can choose any number between 0 - 10. (NCT01301079)
Timeframe: 60 minutes
| Intervention | units on a scale (Mean) |
|---|---|
| Ketamine | 4.6 |
| Saline | 5.1 |
The scale measure pain after 90 minutes (0 - without pain and 10 worst pain possible). The individual can choose any number between 0 - 10. (NCT01301079)
Timeframe: 90 minutes
| Intervention | units on a scale (Mean) |
|---|---|
| Ketamine | 3.4 |
| Saline | 3.4 |
Blood samples were drawn in ethylenediaminetetraacetic acid (EDTA) tubes 24 h after the surgery. The blood was centrifuged to separate the plasma and was stored at -70°C. IL-6 was analyzed using the enzyme-linked immunosorbent assay (ELISA) methodology. (NCT01301079)
Timeframe: 24 h after the procedure
| Intervention | picogram/milliliter (Mean) |
|---|---|
| Ketamine | 8.6 |
| Saline | 5.0 |
Blood samples were drawn in ethylenediaminetetraacetic acid (EDTA) tubes 5 h after the surgery. The blood was centrifuged to separate the plasma and was stored at -70°C. IL-10 was analyzed using the enzyme-linked immunosorbent assay (ELISA) methodology. (NCT01301079)
Timeframe: 5h after the procedure
| Intervention | picogram/milliliter (Mean) |
|---|---|
| Ketamine | 9.1 |
| Saline | 5.5 |
Blood samples were drawn in ethylenediaminetetraacetic acid (EDTA) tubes before the surgery. The blood was centrifuged to separate the plasma and was stored at -70°C. IL-6 was analyzed using the enzyme-linked immunosorbent assay (ELISA) methodology. (NCT01301079)
Timeframe: Baseline (Before the procedure)
| Intervention | picogram/milliliter (Mean) |
|---|---|
| Ketamine | 7.8 |
| Saline | 1.9 |
Blood samples were drawn in ethylenediaminetetraacetic acid (EDTA) tubes 24 h after the surgery. The blood was centrifuged to separate the plasma and was stored at -70°C. IL-6 was analyzed using the enzyme-linked immunosorbent assay (ELISA) methodology. (NCT01301079)
Timeframe: 24 h after the procedure
| Intervention | picogram/milliliter (Mean) |
|---|---|
| Ketamine | 24.1 |
| Saline | 24.8 |
Blood samples were drawn in ethylenediaminetetraacetic acid (EDTA) tubes 5 h after the surgery. The blood was centrifuged to separate the plasma and was stored at -70°C. IL-6 was analyzed using the enzyme-linked immunosorbent assay (ELISA) methodology. (NCT01301079)
Timeframe: 5 h after the procedure
| Intervention | picogram/milliliter (Mean) |
|---|---|
| Ketamine | 29.3 |
| Saline | 34.8 |
Blood samples were drawn in ethylenediaminetetraacetic acid (EDTA) tubes before the surgery. The blood was centrifuged to separate the plasma and was stored at -70°C. IL-6 was analyzed using the enzyme-linked immunosorbent assay (ELISA) methodology. (NCT01301079)
Timeframe: Baseline (Before the procedure)
| Intervention | picogram/milliliter (Mean) |
|---|---|
| Ketamine | 3.3 |
| Saline | 2.1 |
Blood samples were drawn in ethylenediaminetetraacetic acid (EDTA) tubes 24 h after the surgery. The blood was centrifuged to separate the plasma and was stored at -70°C. IL-8 was analyzed using the enzyme-linked immunosorbent assay (ELISA) methodology. (NCT01301079)
Timeframe: 24 h after the procedure
| Intervention | picogram/milliliter (Mean) |
|---|---|
| Ketamine | 6.0 |
| Saline | 4.5 |
Blood samples were drawn in ethylenediaminetetraacetic acid (EDTA) tubes 5 h after the surgery. The blood was centrifuged to separate the plasma and was stored at -70°C. IL-8 was analyzed using the enzyme-linked immunosorbent assay (ELISA) methodology. (NCT01301079)
Timeframe: 5 h after the procedure
| Intervention | picogram/milliliter (Mean) |
|---|---|
| Ketamine | 8.0 |
| Saline | 11.3 |
Blood samples were drawn in ethylenediaminetetraacetic acid (EDTA) tubes before the surgery. The blood was centrifuged to separate the plasma and was stored at -70°C. IL-8 was analyzed using the enzyme-linked immunosorbent assay (ELISA) methodology. (NCT01301079)
Timeframe: Baseline (Before the procedure)
| Intervention | picogram/milliliter (Mean) |
|---|---|
| Ketamine | 3.3 |
| Saline | 2.2 |
(NCT01301079)
Timeframe: 24 hours
| Intervention | minutes (Median) |
|---|---|
| Ketamine | 18 |
| Saline | 15 |
Opioid consumption after discharge (NCT01433081)
Timeframe: 24 hours
| Intervention | miligram morphine equivalents (Median) |
|---|---|
| Magnesium Sulfate Infusion | 10 |
| Placebo | 30 |
Quality of recovery scores post operative. Scored on a scale of 40 (poor recovery) to 200 (good recovery). (NCT01433081)
Timeframe: 24 hours post operative
| Intervention | units on scale 40 (low) - 200 (high) (Mean) |
|---|---|
| Magnesium Sulfate Infusion | 183 |
| Placebo | 159 |
The CY-BOCS is a semi-structured measure of OCD severity with excellent inter-rater reliability, internal consistency, and test-retest reliability. It is validated in those starting at age 7 and used in studies up to age 20. The CYBOCS differs from the adult YBOCS only in its use of simpler language. The CY-BOCS consists of 10 items which are summed up to derive the total CY-BOCS score. The total score ranges from 0-40 with higher scores indicating greater severity of OCD symptoms. (NCT02422290)
Timeframe: Screening, Baseline, Day 7, Day 17, 3-Month; Baseline and Day 14 pre-specified to be reported
| Intervention | score on a scale (Mean) | |
|---|---|---|
| CY-BOCS Baseline | CY-BOCS Day 14 | |
| Ketamine Treatment Group | 29.00 | 26.20 |
The CGI-S is a clinician rated 7-point rating scale for the severity of a participant's illness relative to the clinician's experience of working with this particular population. The score ranges from 1-7 with higher scores indicating greater illness severity. (NCT02422290)
Timeframe: Screening, Baseline, Day 7, Day 17, 3-Month; Baseline and Day 14 pre-specified to be reported
| Intervention | score on a scale (Mean) | |
|---|---|---|
| CGI-S Baseline | CGI-S Day 14 | |
| Ketamine Treatment Group | 5.80 | 5.00 |
"The OCD-VAS is a one-item unipolar scale to assess OCD symptoms over a rapid time frame (No obsessions to Constant obsessions). The scale ranges from 0-10 with higher scores indicating higher presence of obsessions." (NCT02422290)
Timeframe: Screening, Baseline, Day 1-14, 3-Month; Baseline and Day 14 pre-specified to be reported
| Intervention | score on a scale (Mean) | |
|---|---|---|
| OCD-VAS Baseline | OCD-VAS Day 14 | |
| Ketamine Treatment Group | 5.00 | 5.00 |
"The Y-BOCCS is self-report scale which assesses OCD symptoms on a 5-point likert scale (None to Extreme). It consists of 10 items which are summed up to derive the total Y-BOCCS score. The total score ranges from 0-40 with higher scores indicating higher prevalence of OCD symptoms." (NCT02422290)
Timeframe: Screening, Baseline, Day 1-14, 3-Month; Baseline and Day 14 pre-specified to be reported
| Intervention | score on a scale (Mean) | |
|---|---|---|
| Y-BOCCS Baseline | Y-BOCCS Day 14 | |
| Ketamine Treatment Group | 18.25 | 16.50 |
(NCT01986946)
Timeframe: during hospitalization (approximately 3-8 days)
| Intervention | days (Mean) |
|---|---|
| Intravenous Opioids | 4.4 |
| Epidural Catheter | 4.33 |
(NCT01986946)
Timeframe: Post-operative Day 1
| Intervention | participants (Number) |
|---|---|
| Intravenous Opioids | 0 |
| Epidural Catheter | 0 |
(NCT01986946)
Timeframe: Post-operative Day 2
| Intervention | participants (Number) |
|---|---|
| Intravenous Opioids | 0 |
| Epidural Catheter | 0 |
(NCT01986946)
Timeframe: Post-operative Day 3
| Intervention | participants (Number) |
|---|---|
| Intravenous Opioids | 0 |
| Epidural Catheter | 0 |
(NCT01986946)
Timeframe: Post-operative Day 30
| Intervention | participants (Number) |
|---|---|
| Intravenous Opioids | 0 |
| Epidural Catheter | 0 |
Patients will be assessed in the recovery room and each day of their epidural or intravenous opioid infusions, and at their surgical follow-up visit. (NCT01986946)
Timeframe: 6-week Follow up Visit
| Intervention | participants (Number) |
|---|---|
| Intravenous Opioids | 0 |
| Epidural Catheter | 0 |
Likert scale ranges from 1 to 5 (1=very satisfied and 5=Very Dissatisfied). (NCT01986946)
Timeframe: 6-Week Follow up Visit
| Intervention | units on a scale (Mean) |
|---|---|
| Intravenous Opioids | 1 |
| Epidural Catheter | 1.5 |
Patients will be assessed for satisfaction with their peri-operative analgesia in the recovery room and each day of their epidural infusion or intravenous opioid infusion by the Acute Pain Service, and at their surgical follow-up visit. Likert scale ranges from 1 to 5 (1=very satisfied and 5=Very Dissatisfied). (NCT01986946)
Timeframe: 6-Week Follow up Visit
| Intervention | units on a scale (Mean) |
|---|---|
| Intravenous Opioids | 2 |
| Epidural Catheter | 1.5 |
Patients will be assessed for satisfaction with their peri-operative analgesia in the recovery room and each day of their epidural infusion or intravenous opioid infusion by the Acute Pain Service, and at their surgical follow-up visit. Likert scale ranges from 1 to 5 (1=very satisfied and 5=Very Dissatisfied). (NCT01986946)
Timeframe: Post-operative Day 1
| Intervention | units on a scale (Mean) |
|---|---|
| Intravenous Opioids | 2.4 |
| Epidural Catheter | 1.29 |
The VAS scale ranges from 0 to 100 mm with the lower score indicating less pain and the higher score indicating greater pain. (NCT01986946)
Timeframe: Postoperative day 1
| Intervention | units on a scale (Mean) |
|---|---|
| Intravenous Opioids | 36.33 |
| Epidural Catheter | 40.63 |
(NCT01986946)
Timeframe: during hospitalization (approximately 3-8 days)
| Intervention | oral morphine equivilant (mg) (Mean) |
|---|---|
| Intravenous Opioids | 438.52 |
| Epidural Catheter | 410.42 |
Cumulative hydrocodone/acetaminophen for supplemental analgesia to treat breakthrough pain for 72 hours following cesarean delivery (NCT00486902)
Timeframe: 72 hours
| Intervention | tablets (Median) |
|---|---|
| Ketamine | 10 |
| Placebo | 9 |
Number of subject reporting disturbing dreams at 72 hours post cesarean delivery (NCT00486902)
Timeframe: 72 hours
| Intervention | participants (Number) |
|---|---|
| Ketamine | 0 |
| Placebo | 0 |
Request for oral hydrocodone/acetaminophen for pain not controlled by around the clock non-steroidal antiflammatory drugs in the first 24 hours following cesarean delivery. (NCT00486902)
Timeframe: 24 hours
| Intervention | participants (Number) |
|---|---|
| Ketamine | 64 |
| Placebo | 66 |
Numeric rating for pain score (0 to 10) reported at 2 weeks following cesarean delivery. Zero is no pain and 10 is worst pain imaginable. (NCT00486902)
Timeframe: 2 weeks
| Intervention | Scores on a scale (Median) |
|---|---|
| Ketamine | 2 |
| Placebo | 2.6 |
Number of subjects reporting nausea in first 24 hours following cesarean delivery (NCT00486902)
Timeframe: 24 hours
| Intervention | participants (Number) |
|---|---|
| Ketamine | 27 |
| Placebo | 30 |
Number of subjects that vomited in the first 24 hours following cesarean delivery (NCT00486902)
Timeframe: 24 hours
| Intervention | participants (Number) |
|---|---|
| Ketamine | 13 |
| Placebo | 13 |
Number of subjects with pruritus in the first 24 hours following cesarean delivery (NCT00486902)
Timeframe: 24 hours
| Intervention | participants (Number) |
|---|---|
| Ketamine | 12 |
| Placebo | 19 |
Numeric rating of pain scores (NRS) scale (0 to 10) at time of supplemental analgesia request. Zero is no pain and 10 is worst pain imaginable. (NCT00486902)
Timeframe: 24 hours
| Intervention | Scores on a scale (Median) |
|---|---|
| Ketamine | 3 |
| Placebo | 4 |
The numeric rating scale (NRS) is used to measure the intensity of pain. The value 0 means no pain and the value 10 represents maximal pain. a higher intensity of pain is associated with a worse outcome. (NCT00354029)
Timeframe: 24 hours
| Intervention | Units on a scale (Mean) |
|---|---|
| S (+) Ketamine | 1.6 |
| Placebo | 1.5 |
Determine which of three different TAP formulations (Placebo, TAP, Clo-TAP) has the most beneficial effect on the postoperative area of hyperalgesia 48hrs after the start of the cesarean section. The smaller the area of WHA, assessed in cm2, the better the outcome. Area sizes may range from 0 to any size. (NCT01015807)
Timeframe: 48hrs after CS
| Intervention | cm^2 (Mean) |
|---|---|
| Placebo | 1.07 |
| TAP (Bupi) | 1.27 |
| Clo-TAP (Bupi + Clon) | 0.74 |
Pain scores based on a scale of 0 to 10 with 0 being no pain and 10 being the worst pain imaginable. (NCT01366196)
Timeframe: Day of Surgery
| Intervention | units on a scale (Mean) |
|---|---|
| Control Group (C) | 3.8 |
| Pregabalin Group (P) | 2.9 |
Pain scores based on a scale of 0 to 10 with 0 being no pain and 10 being the worst pain imaginable. (NCT01366196)
Timeframe: Postoperative Day 1 at rest
| Intervention | units on a scale (Mean) |
|---|---|
| Control Group (C) | 3.7 |
| Pregabalin Group (P) | 3.3 |
Pain scores based on a scale of 0 to 10 with 0 being no pain and 10 being the worst pain imaginable. (NCT01366196)
Timeframe: Postoperative Day 1 with Physical Therapy
| Intervention | units on a scale (Mean) |
|---|---|
| Control Group (C) | 4.3 |
| Pregabalin Group (P) | 4.5 |
Tabulate number of patients that used supplemental oral analgesics (NCT01366196)
Timeframe: Day of surgery
| Intervention | Participants (Count of Participants) |
|---|---|
| Control Group (C) | 25 |
| Pregabalin Group (P) | 21 |
(NCT01366196)
Timeframe: Postoperative day 1
| Intervention | mL (Mean) |
|---|---|
| Control Group (C) | 44 |
| Pregabalin Group (P) | 39 |
We will monitor for adverse effects and record for changes in vital signs including nausea and vomiting, hypotension, respiratory depression, laryngospasm, and emotional and psychological effects (emergence reactions). (NCT02430818)
Timeframe: 60 minutes
| Intervention | participants (Number) |
|---|---|
| Ketamine | 1 |
| Morphine | 1 |
Study outcomes involve change in participants' pain as measured by a visual analog scale. The scale is a 10 inch line from 0 to 10 inches with 10 being the most pain and 0 being no pain. There are no units on the scale; it is just a straight line from no pain (0) to the worst pain (10). We assessed at o, 15, and 60 minutes but only scored the VAS at 60 minutes. (NCT02430818)
Timeframe: At 0 minutes and 60 minutes
| Intervention | score on a scale (Median) |
|---|---|
| Ketamine | 4 |
| Morphine | 4 |
Patients will be assessed to determine whether the participant would consider using the drug given to them for pain relief in the future. It was measured on a likert scale from 1-5 with 1 being did not like and would not use the drug again to 5 being like and would definitely receive the medication again. There are no units. The numbers below are the total number of patients that completed this answer. This was only asked on patients that received medication as if they did not receive medication the answer would not make sense. The median value is the likert value on a scale of 1-5 with the standard deviation. (NCT02430818)
Timeframe: 60 minutes
| Intervention | units on a scale (Median) |
|---|---|
| Ketamine | 4 |
| Morphine | 4 |
Overall rate of feeling of unreality as measured by Side Effects Rating Scale for Dissociative Anesthetics (SERSDA) (NCT02363270)
Timeframe: 30 minutes
| Intervention | Participants (Count of Participants) |
|---|---|
| IV Push Group | 22 |
| IV Drip Group | 13 |
"We will compare efficacy as a difference between 2 groups in pain score at 30 minutes post-analgesic administration. The primary outcome is the difference between 2 groups in pain score at 30 minutes.~Pain will be measured via Numeric rating scale from 0 to 10 with 0 being no pain, 5 being moderate pain, and 10 being severe pain" (NCT01835262)
Timeframe: 30 minutes
| Intervention | Units on a scale (Mean) |
|---|---|
| Morphine | 3.93 |
| Ketamine Group | 4.07 |
Forced Expiratory Volume (FEV1) is the measurement of how much air, in volume, that a person can exhale with a forced breath. It is measured using a spirometer device. (NCT02922153)
Timeframe: 48-hours post-surgery
| Intervention | Liters (L) (Least Squares Mean) |
|---|---|
| Cryoanalgesia + SOC | 1.2 |
| Standard of Care | 0.93 |
The Visual Analogue Scale (VAS) uses a picture of a linear scale that shows numbers 0-10 with 0 being the least amount of pain and 10 being the most amount of pain. This outcome looked at pain in the surgical region specifically. (NCT02922153)
Timeframe: 48-hours post-surgery
| Intervention | units on a scale (Mean) |
|---|---|
| Cryoanalgesia + SOC | 2.82 |
| Standard of Care | 3.06 |
Oral endotracheal intubation is where a patient has a tube placed down their throat and into the trachea, the large airway from the mouth to the lungs. This is done to ensure that patients who are asleep under anesthesia are able to fully breath. This outcome measured the hours from the time the patient leaves the operating room until they were extubated, or had the tube removed from their trachea. (NCT02922153)
Timeframe: Hours until patient is extubated from time patient leaves the operating room
| Intervention | Hours (Mean) |
|---|---|
| Cryoanalgesia + SOC | 8.85 |
| Standard of Care | 7.33 |
Spirometry assessments measured included: forced expiratory volume (FEV1), forced vital capacity (FVC) and slow vital capacity (SVC), all of which are measured with a spirometer. FEV1 is the amount of air forcibly expired during the first second of breath, FVC is the total volume of air expired over the whole forced breath and SVC is the total volume over the whole breath but at a slow pace, not forced. (NCT02922153)
Timeframe: 48-hours post-extubation
| Intervention | Liters (L) (Mean) | ||
|---|---|---|---|
| FEV1 | FVC | SVC | |
| Cryoanalgesia + SOC | 1.20 | 1.60 | 1.52 |
| Standard of Care | 0.93 | 1.33 | 1.28 |
The Visual Analogue Scale (VAS) uses a picture of a linear scale that shows numbers 0-10 with 0 being the least amount of pain and 10 being the most amount of pain. This outcome looked at pain in the surgical region specifically. (NCT02922153)
Timeframe: 72-, 96- and 120-hours Post-Op
| Intervention | units on a scale (Mean) | ||
|---|---|---|---|
| 72 Hours Post-Op | 96 Hours Post-Op | 120 Hours Post-Op | |
| Cryoanalgesia + SOC | 2.08 | 1.84 | 2.50 |
| Standard of Care | 1.44 | 2.00 | 2.40 |
Allodynia is pain around surgical site. It is pain that occurs from stimuli that are not normally painful such as a light touch or a brush of hair around where the surgery took place. (NCT02922153)
Timeframe: 3 and 6 Months
| Intervention | Participants (Count of Participants) | |
|---|---|---|
| 3 Month | 6 Month | |
| Cryoanalgesia + SOC | 0 | 1 |
| Standard of Care | 0 | 0 |
Patient Controlled Analgesia (PCA) is when the patient chooses to give themselves some form of analgesia, or painkiller, depending on their post-operation pain levels. Oral opioid consumption is the measure of all painkiller medicine that was prescribed by the hospital to the patient to take. This outcome measures each of these up to each time point and also measures the total PCA and oral opioid consumption post-procedure for the whole hospital stay. (NCT02922153)
Timeframe: 24-, 48, -96 and 120-hours
| Intervention | Morphine Milligram Equivalent (MME) (Mean) | ||||
|---|---|---|---|---|---|
| 24 Hours | 48 Hours | 96 Hours | 120 Hours | Total Post-Procedure for Hospital Stay | |
| Cryoanalgesia + SOC | 11.43 | 20.91 | 14.87 | 14.10 | 33.43 |
| Standard of Care | 17.32 | 31.05 | 16.67 | 13.13 | 38.31 |
The outcome measures the time spent in the intensive care unit (ICU) as well as the total hospital length of stay. (NCT02922153)
Timeframe: Procedure to Discharge
| Intervention | Days (Mean) | |
|---|---|---|
| ICU Length of Stay | Hospital Length of Stay | |
| Cryoanalgesia + SOC | 4.96 | 9.40 |
| Standard of Care | 2.96 | 6.32 |
Ambulatory Movement, defined as the subjects ability to sit up, stand up, walk and flex both the left and right shoulders, was measured at multiple time points during hospital stay. (NCT02922153)
Timeframe: Baseline, 48, 72, 96, 120 Hours and Discharge
| Intervention | Participants (Count of Participants) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Baseline - Able to sit up in bed72559592 | Baseline - Able to sit up in bed72559593 | Baseline - Able to stand up72559593 | Baseline - Able to stand up72559592 | Baseline - Able to walk72559593 | Baseline - Able to walk72559592 | Baseline - Right shoulder flexion movement72559592 | Baseline - Right shoulder flexion movement72559593 | Baseline - Left shoulder flexion movement72559593 | Baseline - Left shoulder flexion movement72559592 | 48 Hours - Able to sit up in bed72559592 | 48 Hours - Able to sit up in bed72559593 | 48 Hours - Able to stand up72559592 | 48 Hours - Able to stand up72559593 | 48 Hours - Able to walk72559592 | 48 Hours - Able to walk72559593 | 48 Hours - Right shoulder flexion movement72559592 | 48 Hours - Right shoulder flexion movement72559593 | 48 Hours - Left shoulder flexion movement72559592 | 48 Hours - Left shoulder flexion movement72559593 | 72 Hours - Able to sit up in bed72559592 | 72 Hours - Able to sit up in bed72559593 | 72 Hours - Able to stand up72559592 | 72 Hours - Able to stand up72559593 | 72 Hours - Able to walk72559592 | 72 Hours - Able to walk72559593 | 72 Hours - Right shoulder flexion movement72559592 | 72 Hours - Right shoulder flexion movement72559593 | 72 Hours - Left shoulder flexion movement72559592 | 72 Hours - Left shoulder flexion movement72559593 | 96 Hours - Able to sit up in bed72559592 | 96 Hours - Able to sit up in bed72559593 | 96 Hours - Able to stand up72559592 | 96 Hours - Able to stand up72559593 | 96 Hours - Able to walk72559592 | 96 Hours - Able to walk72559593 | 96 Hours - Right shoulder flexion movement72559592 | 96 Hours - Right shoulder flexion movement72559593 | 96 Hours - Left shoulder flexion movement72559592 | 96 Hours - Left shoulder flexion movement72559593 | 120 Hours - Able to sit up in bed72559592 | 120 Hours - Able to sit up in bed72559593 | 120 Hours - Able to stand up72559593 | 120 Hours - Able to stand up72559592 | 120 Hours - Able to walk72559593 | 120 Hours - Able to walk72559592 | 120 Hours - Right shoulder flexion movement72559593 | 120 Hours - Right shoulder flexion movement72559592 | 120 Hours - Left shoulder flexion movement72559593 | 120 Hours - Left shoulder flexion movement72559592 | Discharge - Able to sit up in bed72559592 | Discharge - Able to sit up in bed72559593 | Discharge - Able to stand up72559592 | Discharge - Able to stand up72559593 | Discharge - Able to walk72559592 | Discharge - Able to walk72559593 | Discharge - Right shoulder flexion movement72559592 | Discharge - Right shoulder flexion movement72559593 | Discharge - Left shoulder flexion movement72559592 | Discharge - Left shoulder flexion movement72559593 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| No | Yes - Independently | Yes - with assistance | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Cryoanalgesia + SOC | 65 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Standard of Care | 0 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Cryoanalgesia + SOC | 64 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Cryoanalgesia + SOC | 63 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Cryoanalgesia + SOC | 27 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Cryoanalgesia + SOC | 21 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Cryoanalgesia + SOC | 38 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Cryoanalgesia + SOC | 16 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Cryoanalgesia + SOC | 26 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Cryoanalgesia + SOC | 33 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Cryoanalgesia + SOC | 43 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Cryoanalgesia + SOC | 47 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Standard of Care | 9 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Cryoanalgesia + SOC | 39 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Cryoanalgesia + SOC | 20 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Standard of Care | 10 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Cryoanalgesia + SOC | 28 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Cryoanalgesia + SOC | 41 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Standard of Care | 5 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Cryoanalgesia + SOC | 1 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Cryoanalgesia + SOC | 49 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Standard of Care | 15 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Standard of Care | 12 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Cryoanalgesia + SOC | 10 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Standard of Care | 3 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Cryoanalgesia + SOC | 32 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Standard of Care | 8 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Cryoanalgesia + SOC | 19 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Standard of Care | 6 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Standard of Care | 7 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Standard of Care | 1 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Standard of Care | 11 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Cryoanalgesia + SOC | 11 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Standard of Care | 4 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Standard of Care | 13 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Standard of Care | 2 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Cryoanalgesia + SOC | 36 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Cryoanalgesia + SOC | 30 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Cryoanalgesia + SOC | 12 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Cryoanalgesia + SOC | 23 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Cryoanalgesia + SOC | 17 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Cryoanalgesia + SOC | 34 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Cryoanalgesia + SOC | 37 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Cryoanalgesia + SOC | 53 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Standard of Care | 19 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Cryoanalgesia + SOC | 0 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Cryoanalgesia + SOC | 51 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Standard of Care | 17 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Cryoanalgesia + SOC | 7 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Cryoanalgesia + SOC | 50 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Cryoanalgesia + SOC | 8 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Cryoanalgesia + SOC | 2 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Cryoanalgesia + SOC | 54 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Standard of Care | 16 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Cryoanalgesia + SOC | 6 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Cryoanalgesia + SOC | 5 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Cryoanalgesia + SOC | 4 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
The primary outcome will be the comparative reduction of NRS pain scores between the 2 groups at 30 minutes. The NRS Pain scale ranges from 0 to 10 (0 being no pain at all to 10 being very severe pain; 5 is moderate pain) (NCT02673372)
Timeframe: 30 minutes
| Intervention | score on a scale (Mean) |
|---|---|
| Morphine Group | 4.4 |
| Ketamine Group | 4.2 |
The patient will be assessed for vital signs (blood pressure, heart rate, respiratory rate, oxygen saturation), Ramsay Sedation Scale (RSS) score at 5,10,20 minutes following medication administration and then every 20 minutes until a total of 120 minutes from the first dose of study medication. outlying vital signs recorded.( systolic Blood pressure less than 90mmHg or greater than 150mmHg, Heart rate less than 50bpm or greater than 150bpm, oxygen saturation below 90%, respiratory rate below 9breaths/minute or greater than 40breaths/minute and RSS of 1 or greater than 3) The RSS was used to asses the level of agitation or sedation caused by the intervention .the scale ranges from 1(anxious/agitated) to 6( no response to stimulus-deep sedation) with 2 being the optimal (cooperative, oriented and tranquil).A checklist for side effects like airway problems, allergic reactions, salivation, dysphoria,nystagmus, respiratory/cardiac arrest, awakening hallucinations, nausea/vomiting was used (NCT02434939)
Timeframe: 5, 10, 20, 40, 60, 80, 100, 120 minutes post drug administration
| Intervention | participants (Number) |
|---|---|
| Low Dose Ketamine | 45 |
| Morphine | 4 |
Requiring more than two doses of the study medication provided for adequate pain control (NCT02434939)
Timeframe: 120 minutes
| Intervention | participants (Number) |
|---|---|
| Low Dose Ketamine | 34 |
| Morphine | 48 |
Our primary outcome measurement was the maximum change on the verbal NRS pain scale compared with their initial score (baseline). The NRS was used to measure a patient's subjective level of pain on a scale from 0 (representing no pain at all) to 10 (the worst pain imaginable) using whole numbers. The NRS score was documented just prior to the administration of the study drug (time zero). After infusion of the study drug was complete, NRS scores were documented at 5, 10, 20, and then every 20 minutes thereafter up to 120 minutes. We stopped recording NRS scores prior to 120 minutes if the patient requested a third dose of the study drug, withdrew consent or developed a severe adverse effect. (NCT02434939)
Timeframe: 5, 10, 20,25,30, 40,45,50 60, 80, 100, 120 minutes post drug adminstration
| Intervention | percent change from baseline NRS score. (Mean) | |||
|---|---|---|---|---|
| Overall | Excluding Treatment failures | Among Treatment failures | Those still at maximal effect at 120 | |
| Low Dose Ketamine | -66.4 | -81.1 | -33.8 | -80 |
| Morphine | -61.3 | -79.8 | -33.9 | -81.7 |
"Following dosage with study medication, the amount of time taken to demonstrate the maximal change in the patient's NRS pain score.~Maximal change in NRS pain score is to be defined as the largest change from patient's baseline pain score. Duration of maximal change is how long the patient's pain score remained at this level." (NCT02434939)
Timeframe: 5, 10, 20, 40, 60, 80, 100, 120 minutes post drug administration
| Intervention | minutes (Mean) | |
|---|---|---|
| time to maximal effect | duration of maximal effect | |
| Low Dose Ketamine | 19.8 | 60 |
| Morphine | 34.1 | 58.5 |
OOWS: Is a 13-item instrument of documenting physically observable signs of withdrawal, which are rated as present (1) or absent (0) during the observation period. Maximum score = 13, minimum score = 0. Lower scores correspond to fewer symptoms. (NCT01222091)
Timeframe: Pretreatment [90 min prior to 60-min REM infusion]; 30 min prior to 60-min REM infusion; 15 and 40 min after start of 60-min REM infusion; 5, 15, and 75 minutes after finish of 60-min REM infusion)
| Intervention | units on a scale (Mean) | ||||||
|---|---|---|---|---|---|---|---|
| Pretreatment | 30 min prior to REM infusion | 15 min after start of REM infusion | 40 min after start of REM infusion | 5 minutes after finish of REM infusion | 15 minutes after finish of REM infusion | 75 minutes after finish of REM infusion | |
| Placebo | 1.1 | 1.1 | 0.8 | 0.5 | 1.8 | 2.1 | 1.6 |
| Propranolol | 1.2 | 1.1 | 0.1 | 0.8 | 3 | 2.8 | 1.7 |
A slightly modified version of a previously described model of secondary hyperalgesia was used. Two copper wires contained in a microdialysis catheter were inserted in parallel over a length of 5 mm into the dermis of the right volar forearm. The wires were connected to a constant current stimulator controlled by a pulse generator to deliver rectangular and monophasic pulses with a duration of 0.5 mg at 2 Hz. Over a period of 15 min, the current was increased by targeting a pain rating of 5 on an 11-point numeric rating scale (0 = no pain and 10 = maximum tolerable pain) until the hyperalgesic area surrounding the stimulation site was fully established. Once the area was established, the current was held constant. Percent change from baseline in size (area) of secondary hyperalgesia after cessation of remifentanil infusion was calculated per group. (NCT01222091)
Timeframe: Baseline; 15 min post remifentanil (REM) infusion; 60 min post REM infusion
| Intervention | percentage of change (Number) | |
|---|---|---|
| 15 min post remifentanil infusion | 60 min post remifentanil infusion | |
| Placebo | -34 | 141.5 |
| Propranolol | -28 | -19 |
103 reviews available for ketamine and Pain, Postoperative
| Article | Year |
|---|---|
Impact of Intraoperative Ketamine on Postoperative Analgesic Requirement Following Bariatric Surgery: a Meta-analysis of Randomized Controlled Trials.
Topics: Analgesics; Analgesics, Opioid; Bariatric Surgery; Humans; Ketamine; Morphine; Obesity, Morbid; Pain | 2021 |
The effect of intravenous ketamine on depressive symptoms after surgery: A systematic review.
Topics: Adult; Antidepressive Agents; Depression; Humans; Ketamine; Nausea; Pain, Postoperative | 2022 |
Quality of meta-analyses of non-opioid, pharmacological, perioperative interventions for chronic postsurgical pain: a systematic review.
Topics: Adult; Chronic Pain; Gabapentin; Humans; Ketamine; Pain, Postoperative; Pregabalin | 2022 |
Perioperative ketamine for postoperative pain management in patients with preoperative opioid intake: A systematic review and meta-analysis.
Topics: Acute Pain; Adult; Analgesics, Opioid; Humans; Hyperalgesia; Ketamine; Pain, Postoperative | 2022 |
Different interventions for preventing postoperative catheter-related bladder discomfort: a systematic review and meta-analysis.
Topics: Chlorpheniramine; Dexmedetomidine; Gabapentin; Haloperidol; Humans; Ketamine; Lidocaine; Meperidine; | 2022 |
Perioperative Low-Dose Ketamine for Postoperative Pain Management in Spine Surgery: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Topics: Analgesics; Analgesics, Opioid; Child; Humans; Ketamine; Pain, Postoperative; Randomized Controlled | 2022 |
Statistical Fragility of Ketamine Infusion During Scoliosis Surgery to Reduce Opioid Tolerance and Postoperative Pain.
Topics: Adolescent; Analgesics, Opioid; Humans; Ketamine; Pain, Postoperative; Sample Size; Scoliosis | 2022 |
Utilization of Ketamine in Total Knee and Hip Joint Arthroplasty: An Evidence-Based Review.
Topics: Analgesics, Opioid; Arthroplasty, Replacement, Hip; Arthroplasty, Replacement, Knee; Hip Joint; Huma | 2023 |
Meta-analysis of the efficacy of ketamine in postoperative pain control in adolescent idiopathic scoliosis patients undergoing spinal fusion.
Topics: Adolescent; Analgesics, Opioid; Humans; Ketamine; Kyphosis; Morphine; Pain, Postoperative; Saline So | 2022 |
A Systematic Review of the Efficacy and Safety of Ketamine in Total Joint Arthroplasty.
Topics: Aged; Analgesics, Opioid; Arthroplasty, Replacement, Hip; Arthroplasty, Replacement, Knee; Humans; K | 2023 |
Efficacy and safety of perioperative application of ketamine on postoperative depression: A meta-analysis of randomized controlled studies.
Topics: Antidepressive Agents; Depression; Depressive Disorder; Humans; Ketamine; Pain; Pain, Postoperative; | 2023 |
The efficacy and safety of peri-tonsillar administrated agents on pain treatment after pediatric tonsillectomy: A network meta-analysis.
Topics: Analgesics; Analgesics, Opioid; Bupivacaine; Child; Dexamethasone; Double-Blind Method; Humans; Keta | 2023 |
The analgesic efficacy of ketamine for septorhinoplasty: a meta-analysis study.
Topics: Analgesics; Humans; Ketamine; Pain Management; Pain, Postoperative; Vomiting | 2023 |
Non-opioid analgesics for the prevention of chronic postsurgical pain: a systematic review and network meta-analysis.
Topics: Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Humans; Ketamine; Lidocaine; Network Meta- | 2023 |
Effects of Ketamine on Chronic Postsurgical Pain in Patients Undergoing Surgery: A Systematic Review and Meta-analysis.
Topics: Analgesics, Opioid; Chronic Pain; Humans; Ketamine; Pain, Postoperative; Postoperative Nausea and Vo | 2023 |
Intravenous ketamine in gynaecological surgeries reduces pain score and opioid consumption.
Topics: Analgesics, Opioid; Female; Gynecologic Surgical Procedures; Humans; Ketamine; Pain, Postoperative; | 2022 |
The Emerging Role of Ketamine in Acute Postoperative Pain Management.
Topics: Analgesics; Analgesics, Opioid; Humans; Ketamine; Pain, Postoperative | 2023 |
Perioperative Use of Ketamine.
Topics: Analgesia; Analgesics, Opioid; Humans; Ketamine; Pain Management; Pain, Postoperative | 2023 |
Effect of S-ketamine on Postoperative Pain in Adults Post-Abdominal Surgery: A Systematic Review and Meta-analysis.
Topics: Abdomen; Adult; Analgesics, Opioid; Humans; Ketamine; Pain, Postoperative; Postoperative Nausea and | 2023 |
Local Ketamine Improves Postoperative Analgesia After Third Molar Surgery.
Topics: Adolescent; Adult; Analgesia; Analgesics; Edema; Female; Humans; Ketamine; Male; Middle Aged; Molar, | 2019 |
Ketamine reduces pain and opioid consumption after total knee arthroplasty: A meta-analysis of randomized controlled studies.
Topics: Analgesics, Opioid; Arthroplasty, Replacement, Knee; Humans; Ketamine; Morphine; Pain, Postoperative | 2019 |
Analgesic efficacy and safety of ketamine after total knee or hip arthroplasty: a meta-analysis of randomised placebo-controlled studies.
Topics: Analgesics; Arthroplasty, Replacement, Hip; Arthroplasty, Replacement, Knee; Humans; Ketamine; Morph | 2019 |
The effect of ketamine on emergence agitation in children: A systematic review and meta-analysis.
Topics: Adolescent; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Inhalation; Child; Child, | 2019 |
Adjuvants in clinical regional anesthesia practice: A comprehensive review.
Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics, Opioid; Anesthesia, Conduction; Anesthetics, Local | 2019 |
Postoperative pain control following minimally invasive correction of pectus excavatum in pediatric patients: A systematic review.
Topics: Adolescent; Analgesics; Analgesics, Opioid; Bupivacaine; Child; Funnel Chest; Humans; Ketamine; Mini | 2020 |
Impact of Ketamine on Pain Management in Cesarean Section: A Systematic Review and Meta-Analysis.
Topics: Analgesia; Analgesics; Cesarean Section; Female; Humans; Ketamine; Morphine; Pain Management; Pain, | 2020 |
Perioperative Analgesia for Patients Undergoing Thyroidectomy and Parathyroidectomy: An Evidence-Based Review.
Topics: Acetaminophen; Analgesics; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Evidence-Bas | 2020 |
Perioperative intravenous S-ketamine for acute postoperative pain in adults: A systematic review and meta-analysis.
Topics: Adult; Analgesics, Opioid; Humans; Ketamine; Male; Pain Measurement; Pain, Postoperative | 2021 |
A Systematic Review of Intra-Articular Ketamine for Postoperative Analgesia.
Topics: Adult; Analgesia; Analgesics; Analgesics, Opioid; Arthralgia; Female; Humans; Injections, Intra-Arti | 2020 |
Analgesic effect of perioperative ketamine for total hip arthroplasties and total knee arthroplasties: A PRISMA-compliant meta-analysis.
Topics: Analgesics; Analgesics, Opioid; Arthroplasty, Replacement, Hip; Arthroplasty, Replacement, Knee; Hum | 2020 |
The Effect of Ketamine on Acute and Chronic Wound Pain in Patients Undergoing Breast Surgery: A Meta-Analysis and Systematic Review.
Topics: Acute Pain; Analgesics; Analgesics, Opioid; Breast Neoplasms; Bupivacaine; Chronic Pain; Female; Hum | 2021 |
Ketamine Use in the Surgical Patient: a Literature Review.
Topics: Analgesics; Analgesics, Opioid; Anesthesia; Humans; Infusions, Intravenous; Ketamine; Pain Managemen | 2021 |
The comparison of ketamine with tramadol for postoperative pain relief on children following adenotonsillectomy or tonsillectomy: A meta-analysis of randomized controlled trials.
Topics: Adenoidectomy; Analgesics; Child; Child, Preschool; Female; Humans; Ketamine; Male; Pain, Postoperat | 2021 |
Clinical application of perioperative multimodal analgesia.
Topics: Amines; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Cyclohexanecarboxyl | 2017 |
Perioperative Ketamine Administration for Thoracotomy Pain.
Topics: Humans; Ketamine; Pain, Postoperative; Randomized Controlled Trials as Topic; Thoracotomy | 2017 |
Perioperative Ketamine for Analgesia in Spine Surgery: A Meta-analysis of Randomized Controlled Trials.
Topics: Analgesia; Analgesics; Analgesics, Opioid; Humans; Ketamine; Morphine; Pain Management; Pain, Postop | 2018 |
Efficiency and safety of ketamine for pain relief after laparoscopic cholecystectomy: A meta-analysis from randomized controlled trials.
Topics: Adult; Analgesics; Cholecystectomy, Laparoscopic; Female; Humans; Ketamine; Male; Middle Aged; Pain | 2018 |
Effect of intravenous ketamine for postoperative analgesia in patients undergoing laparoscopic cholecystectomy: A meta-analysis.
Topics: Analgesics; Cholecystectomy, Laparoscopic; Drug Utilization; Humans; Infusions, Intravenous; Ketamin | 2017 |
Adjuvant analgesics for spine surgery.
Topics: Analgesia; Analgesics, Opioid; Chlorzoxazone; Chronic Pain; Dexamethasone; Humans; Intraoperative Pe | 2018 |
Adjuvant analgesics for spine surgery.
Topics: Analgesia; Analgesics, Opioid; Chlorzoxazone; Chronic Pain; Dexamethasone; Humans; Intraoperative Pe | 2018 |
Adjuvant analgesics for spine surgery.
Topics: Analgesia; Analgesics, Opioid; Chlorzoxazone; Chronic Pain; Dexamethasone; Humans; Intraoperative Pe | 2018 |
Adjuvant analgesics for spine surgery.
Topics: Analgesia; Analgesics, Opioid; Chlorzoxazone; Chronic Pain; Dexamethasone; Humans; Intraoperative Pe | 2018 |
Adjuvant analgesics for spine surgery.
Topics: Analgesia; Analgesics, Opioid; Chlorzoxazone; Chronic Pain; Dexamethasone; Humans; Intraoperative Pe | 2018 |
Adjuvant analgesics for spine surgery.
Topics: Analgesia; Analgesics, Opioid; Chlorzoxazone; Chronic Pain; Dexamethasone; Humans; Intraoperative Pe | 2018 |
Adjuvant analgesics for spine surgery.
Topics: Analgesia; Analgesics, Opioid; Chlorzoxazone; Chronic Pain; Dexamethasone; Humans; Intraoperative Pe | 2018 |
Adjuvant analgesics for spine surgery.
Topics: Analgesia; Analgesics, Opioid; Chlorzoxazone; Chronic Pain; Dexamethasone; Humans; Intraoperative Pe | 2018 |
Adjuvant analgesics for spine surgery.
Topics: Analgesia; Analgesics, Opioid; Chlorzoxazone; Chronic Pain; Dexamethasone; Humans; Intraoperative Pe | 2018 |
Adjuvant analgesics for spine surgery.
Topics: Analgesia; Analgesics, Opioid; Chlorzoxazone; Chronic Pain; Dexamethasone; Humans; Intraoperative Pe | 2018 |
Adjuvant analgesics for spine surgery.
Topics: Analgesia; Analgesics, Opioid; Chlorzoxazone; Chronic Pain; Dexamethasone; Humans; Intraoperative Pe | 2018 |
Adjuvant analgesics for spine surgery.
Topics: Analgesia; Analgesics, Opioid; Chlorzoxazone; Chronic Pain; Dexamethasone; Humans; Intraoperative Pe | 2018 |
Adjuvant analgesics for spine surgery.
Topics: Analgesia; Analgesics, Opioid; Chlorzoxazone; Chronic Pain; Dexamethasone; Humans; Intraoperative Pe | 2018 |
Adjuvant analgesics for spine surgery.
Topics: Analgesia; Analgesics, Opioid; Chlorzoxazone; Chronic Pain; Dexamethasone; Humans; Intraoperative Pe | 2018 |
Adjuvant analgesics for spine surgery.
Topics: Analgesia; Analgesics, Opioid; Chlorzoxazone; Chronic Pain; Dexamethasone; Humans; Intraoperative Pe | 2018 |
Adjuvant analgesics for spine surgery.
Topics: Analgesia; Analgesics, Opioid; Chlorzoxazone; Chronic Pain; Dexamethasone; Humans; Intraoperative Pe | 2018 |
Chronic postsurgical pain and cancer: the catch of surviving the unsurvivable.
Topics: Analgesics; Analgesics, Opioid; Cancer Pain; Chronic Pain; Drug Therapy, Combination; Gabapentin; Ge | 2018 |
Stable anesthesia with alternative to opioids: Are ketamine and magnesium helpful in stabilizing hemodynamics during surgery? A systematic review and meta-analyses of randomized controlled trials.
Topics: Analgesics; Analgesics, Opioid; Anesthesia; Hemodynamics; Humans; Intraoperative Care; Ketamine; Mag | 2017 |
Hypnotic agents for induction of general anesthesia in cesarean section patients: A systematic review and meta-analysis of randomized controlled trials.
Topics: Anesthesia, General; Anesthetics, Intravenous; Apgar Score; Blood Gas Analysis; Cesarean Section; Fe | 2018 |
Intra- and postoperative intravenous ketamine does not prevent chronic pain: A systematic review and meta-analysis.
Topics: Analgesics; Chronic Pain; Humans; Intraoperative Care; Ketamine; Pain, Postoperative; Postoperative | 2015 |
Updates on Multimodal Analgesia for Orthopedic Surgery.
Topics: Acetaminophen; Amines; Analgesia; Celecoxib; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobut | 2018 |
Perioperative intravenous ketamine for acute postoperative pain in adults.
Topics: Acute Pain; Adult; Analgesics; Analgesics, Opioid; Central Nervous System Diseases; Humans; Hyperalg | 2018 |
Perioperative intravenous ketamine for acute postoperative pain in adults.
Topics: Acute Pain; Adult; Analgesics; Analgesics, Opioid; Central Nervous System Diseases; Humans; Hyperalg | 2018 |
Perioperative intravenous ketamine for acute postoperative pain in adults.
Topics: Acute Pain; Adult; Analgesics; Analgesics, Opioid; Central Nervous System Diseases; Humans; Hyperalg | 2018 |
Perioperative intravenous ketamine for acute postoperative pain in adults.
Topics: Acute Pain; Adult; Analgesics; Analgesics, Opioid; Central Nervous System Diseases; Humans; Hyperalg | 2018 |
Perioperative intravenous ketamine for acute postoperative pain in adults.
Topics: Acute Pain; Adult; Analgesics; Analgesics, Opioid; Central Nervous System Diseases; Humans; Hyperalg | 2018 |
Perioperative intravenous ketamine for acute postoperative pain in adults.
Topics: Acute Pain; Adult; Analgesics; Analgesics, Opioid; Central Nervous System Diseases; Humans; Hyperalg | 2018 |
Perioperative intravenous ketamine for acute postoperative pain in adults.
Topics: Acute Pain; Adult; Analgesics; Analgesics, Opioid; Central Nervous System Diseases; Humans; Hyperalg | 2018 |
Perioperative intravenous ketamine for acute postoperative pain in adults.
Topics: Acute Pain; Adult; Analgesics; Analgesics, Opioid; Central Nervous System Diseases; Humans; Hyperalg | 2018 |
Perioperative intravenous ketamine for acute postoperative pain in adults.
Topics: Acute Pain; Adult; Analgesics; Analgesics, Opioid; Central Nervous System Diseases; Humans; Hyperalg | 2018 |
Perioperative intravenous ketamine for acute postoperative pain in adults.
Topics: Acute Pain; Adult; Analgesics; Analgesics, Opioid; Central Nervous System Diseases; Humans; Hyperalg | 2018 |
Perioperative intravenous ketamine for acute postoperative pain in adults.
Topics: Acute Pain; Adult; Analgesics; Analgesics, Opioid; Central Nervous System Diseases; Humans; Hyperalg | 2018 |
Perioperative intravenous ketamine for acute postoperative pain in adults.
Topics: Acute Pain; Adult; Analgesics; Analgesics, Opioid; Central Nervous System Diseases; Humans; Hyperalg | 2018 |
Perioperative intravenous ketamine for acute postoperative pain in adults.
Topics: Acute Pain; Adult; Analgesics; Analgesics, Opioid; Central Nervous System Diseases; Humans; Hyperalg | 2018 |
Perioperative intravenous ketamine for acute postoperative pain in adults.
Topics: Acute Pain; Adult; Analgesics; Analgesics, Opioid; Central Nervous System Diseases; Humans; Hyperalg | 2018 |
Perioperative intravenous ketamine for acute postoperative pain in adults.
Topics: Acute Pain; Adult; Analgesics; Analgesics, Opioid; Central Nervous System Diseases; Humans; Hyperalg | 2018 |
Perioperative intravenous ketamine for acute postoperative pain in adults.
Topics: Acute Pain; Adult; Analgesics; Analgesics, Opioid; Central Nervous System Diseases; Humans; Hyperalg | 2018 |
Perioperative intravenous ketamine for acute postoperative pain in adults.
Topics: Acute Pain; Adult; Analgesics; Analgesics, Opioid; Central Nervous System Diseases; Humans; Hyperalg | 2018 |
Perioperative intravenous ketamine for acute postoperative pain in adults.
Topics: Acute Pain; Adult; Analgesics; Analgesics, Opioid; Central Nervous System Diseases; Humans; Hyperalg | 2018 |
Perioperative intravenous ketamine for acute postoperative pain in adults.
Topics: Acute Pain; Adult; Analgesics; Analgesics, Opioid; Central Nervous System Diseases; Humans; Hyperalg | 2018 |
Perioperative intravenous ketamine for acute postoperative pain in adults.
Topics: Acute Pain; Adult; Analgesics; Analgesics, Opioid; Central Nervous System Diseases; Humans; Hyperalg | 2018 |
Perioperative intravenous ketamine for acute postoperative pain in adults.
Topics: Acute Pain; Adult; Analgesics; Analgesics, Opioid; Central Nervous System Diseases; Humans; Hyperalg | 2018 |
Perioperative intravenous ketamine for acute postoperative pain in adults.
Topics: Acute Pain; Adult; Analgesics; Analgesics, Opioid; Central Nervous System Diseases; Humans; Hyperalg | 2018 |
Perioperative intravenous ketamine for acute postoperative pain in adults.
Topics: Acute Pain; Adult; Analgesics; Analgesics, Opioid; Central Nervous System Diseases; Humans; Hyperalg | 2018 |
Perioperative intravenous ketamine for acute postoperative pain in adults.
Topics: Acute Pain; Adult; Analgesics; Analgesics, Opioid; Central Nervous System Diseases; Humans; Hyperalg | 2018 |
Perioperative intravenous ketamine for acute postoperative pain in adults.
Topics: Acute Pain; Adult; Analgesics; Analgesics, Opioid; Central Nervous System Diseases; Humans; Hyperalg | 2018 |
The efficacy of ketamine supplementation on pain management for knee arthroscopy: A meta-analysis of randomized controlled trials.
Topics: Adult; Aged; Analgesics; Arthroplasty, Replacement, Knee; Female; Humans; Ketamine; Male; Middle Age | 2019 |
Low-dose ketamine in painful orthopaedic surgery: a systematic review and meta-analysis.
Topics: Analgesics; Analgesics, Opioid; Anesthetics, Dissociative; Dose-Response Relationship, Drug; Drug Ad | 2019 |
Chronic pain after childbirth.
Topics: Acute Pain; Adrenergic alpha-Agonists; Adult; Amines; Analgesics; Anesthetics, Dissociative; Cesarea | 2013 |
Pharmacotherapy for the prevention of chronic pain after surgery in adults.
Topics: Adrenal Cortex Hormones; Adult; Amines; Analgesics; Chronic Pain; Cyclohexanecarboxylic Acids; Femal | 2013 |
['Postoperative pain treatment' practice guideline revised].
Topics: Adult; Amines; Analgesia, Epidural; Child; Cyclohexanecarboxylic Acids; Dexamethasone; Gabapentin; g | 2013 |
Postoperative pain management after total knee arthroplasty in elderly patients: treatment options.
Topics: Acetaminophen; Acute Pain; Aged; Analgesics, Opioid; Anesthesia; Anesthesia, Conduction; Anti-Inflam | 2014 |
Postoperative pain management after total knee arthroplasty in elderly patients: treatment options.
Topics: Acetaminophen; Acute Pain; Aged; Analgesics, Opioid; Anesthesia; Anesthesia, Conduction; Anti-Inflam | 2014 |
Postoperative pain management after total knee arthroplasty in elderly patients: treatment options.
Topics: Acetaminophen; Acute Pain; Aged; Analgesics, Opioid; Anesthesia; Anesthesia, Conduction; Anti-Inflam | 2014 |
Postoperative pain management after total knee arthroplasty in elderly patients: treatment options.
Topics: Acetaminophen; Acute Pain; Aged; Analgesics, Opioid; Anesthesia; Anesthesia, Conduction; Anti-Inflam | 2014 |
Postoperative pain management after total knee arthroplasty in elderly patients: treatment options.
Topics: Acetaminophen; Acute Pain; Aged; Analgesics, Opioid; Anesthesia; Anesthesia, Conduction; Anti-Inflam | 2014 |
Postoperative pain management after total knee arthroplasty in elderly patients: treatment options.
Topics: Acetaminophen; Acute Pain; Aged; Analgesics, Opioid; Anesthesia; Anesthesia, Conduction; Anti-Inflam | 2014 |
Postoperative pain management after total knee arthroplasty in elderly patients: treatment options.
Topics: Acetaminophen; Acute Pain; Aged; Analgesics, Opioid; Anesthesia; Anesthesia, Conduction; Anti-Inflam | 2014 |
Postoperative pain management after total knee arthroplasty in elderly patients: treatment options.
Topics: Acetaminophen; Acute Pain; Aged; Analgesics, Opioid; Anesthesia; Anesthesia, Conduction; Anti-Inflam | 2014 |
Postoperative pain management after total knee arthroplasty in elderly patients: treatment options.
Topics: Acetaminophen; Acute Pain; Aged; Analgesics, Opioid; Anesthesia; Anesthesia, Conduction; Anti-Inflam | 2014 |
Topical and peripheral ketamine as an analgesic.
Topics: Administration, Topical; Analgesics; Clinical Trials as Topic; Drug Therapy, Combination; Humans; Ke | 2014 |
Efficacy of ketamine in improving pain after tonsillectomy in children: meta-analysis.
Topics: Adolescent; Analgesics, Opioid; Child; Child, Preschool; Female; Humans; Infant; Ketamine; Male; Pai | 2014 |
A systematic review and meta-analysis of ketamine for the prevention of persistent post-surgical pain.
Topics: Anesthetics, Dissociative; Chronic Pain; Humans; Ketamine; Pain, Postoperative | 2014 |
Ketamine peritonsillar infiltration during tonsillectomy in pediatric patients: An updated meta-analysis.
Topics: Analgesics; Child; Child, Preschool; Humans; Incidence; Ketamine; Pain Measurement; Pain, Postoperat | 2014 |
Preemptive analgesia effects of ketamine in patients undergoing surgery. A meta-analysis.
Topics: Analgesics; Analgesics, Opioid; Humans; Ketamine; Morphine; Operative Time; Pain Measurement; Pain, | 2014 |
The use of intravenous infusion or single dose of low-dose ketamine for postoperative analgesia: a review of the current literature.
Topics: Analgesics; Humans; Infusions, Intravenous; Injections, Intravenous; Ketamine; Molecular Sequence Da | 2015 |
WITHDRAWN: Perioperative ketamine for acute postoperative pain.
Topics: Analgesics; Humans; Infusions, Intravenous; Ketamine; Pain, Postoperative; Postoperative Nausea and | 2015 |
Role of ketamine in acute postoperative pain management: a narrative review.
Topics: Acute Pain; Anesthetics, Dissociative; Dose-Response Relationship, Drug; Evidence-Based Medicine; Hu | 2015 |
Role of ketamine in acute postoperative pain management: a narrative review.
Topics: Acute Pain; Anesthetics, Dissociative; Dose-Response Relationship, Drug; Evidence-Based Medicine; Hu | 2015 |
Role of ketamine in acute postoperative pain management: a narrative review.
Topics: Acute Pain; Anesthetics, Dissociative; Dose-Response Relationship, Drug; Evidence-Based Medicine; Hu | 2015 |
Role of ketamine in acute postoperative pain management: a narrative review.
Topics: Acute Pain; Anesthetics, Dissociative; Dose-Response Relationship, Drug; Evidence-Based Medicine; Hu | 2015 |
Trends and New Evidence in the Management of Acute and Chronic Post-Thoracotomy Pain-An Overview of the Literature from 2005 to 2015.
Topics: Adrenergic alpha-2 Receptor Agonists; Analgesia, Epidural; Anesthesia, Intravenous; Anti-Inflammator | 2016 |
Preventing chronic postoperative pain.
Topics: Amines; Analgesics; Chronic Pain; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; | 2016 |
Ketamine added to morphine or hydromorphone patient-controlled analgesia for acute postoperative pain in adults: a systematic review and meta-analysis of randomized trials.
Topics: Acute Pain; Adult; Analgesia, Patient-Controlled; Drug Combinations; Humans; Hydromorphone; Ketamine | 2016 |
Managing Opioid-Tolerant Patients in the Perioperative Surgical Home.
Topics: Analgesics, Opioid; Drug Tolerance; Humans; Intraoperative Care; Ketamine; Pain, Postoperative; Post | 2016 |
Can Chronic Pain Be Prevented?
Topics: Acute Pain; Amines; Anesthesia, Conduction; Chronic Pain; Cyclohexanecarboxylic Acids; Epigenesis, G | 2016 |
Opioid-Sparing Effect of Ketamine in Children: A Meta-Analysis and Trial Sequential Analysis of Published Studies.
Topics: Analgesics, Opioid; Child; Humans; Ketamine; Pain, Postoperative; Postoperative Nausea and Vomiting | 2016 |
Analgesia in the surgical intensive care unit.
Topics: Acetaminophen; Amines; Analgesics; Analgesics, Opioid; Anesthesia, Conduction; Anesthetics, Local; C | 2017 |
Benefit and harm of adding ketamine to an opioid in a patient-controlled analgesia device for the control of postoperative pain: systematic review and meta-analyses of randomized controlled trials with trial sequential analyses.
Topics: Analgesics; Analgesics, Opioid; Drug Delivery Systems; Humans; Ketamine; Pain, Postoperative; Random | 2016 |
[Patient-controlled analgesia. Pain and Locoregional Anesthesia Committee and the Standards Committee of the French Society of Anesthesia and Intensive Care].
Topics: Analgesia, Patient-Controlled; Antiemetics; Droperidol; Drug Administration Routes; Drug Synergism; | 2009 |
Role of N-methyl-D-aspartate receptor antagonists in postoperative pain management.
Topics: Analgesics, Opioid; Dextromethorphan; Drug Combinations; Drug Therapy, Combination; Excitatory Amino | 2009 |
Clinical uses of low-dose ketamine in patients undergoing surgery.
Topics: Anesthesia, General; Anesthesia, Local; Anesthetics, Dissociative; Dose-Response Relationship, Drug; | 2009 |
Postoperative analgesia in children: an update.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Child; Fentanyl; Humans; Ketamine; Meperidine; Morphine; Pa | 2009 |
Adding ketamine to morphine for intravenous patient-controlled analgesia for acute postoperative pain: a qualitative review of randomized trials.
Topics: Acute Disease; Analgesia, Patient-Controlled; Analgesics; Double-Blind Method; Drug Combinations; Hu | 2010 |
Adding ketamine to morphine for intravenous patient-controlled analgesia for acute postoperative pain: a qualitative review of randomized trials.
Topics: Acute Disease; Analgesia, Patient-Controlled; Analgesics; Double-Blind Method; Drug Combinations; Hu | 2010 |
Adding ketamine to morphine for intravenous patient-controlled analgesia for acute postoperative pain: a qualitative review of randomized trials.
Topics: Acute Disease; Analgesia, Patient-Controlled; Analgesics; Double-Blind Method; Drug Combinations; Hu | 2010 |
Adding ketamine to morphine for intravenous patient-controlled analgesia for acute postoperative pain: a qualitative review of randomized trials.
Topics: Acute Disease; Analgesia, Patient-Controlled; Analgesics; Double-Blind Method; Drug Combinations; Hu | 2010 |
Adding ketamine to morphine for intravenous patient-controlled analgesia for acute postoperative pain: a qualitative review of randomized trials.
Topics: Acute Disease; Analgesia, Patient-Controlled; Analgesics; Double-Blind Method; Drug Combinations; Hu | 2010 |
Adding ketamine to morphine for intravenous patient-controlled analgesia for acute postoperative pain: a qualitative review of randomized trials.
Topics: Acute Disease; Analgesia, Patient-Controlled; Analgesics; Double-Blind Method; Drug Combinations; Hu | 2010 |
Adding ketamine to morphine for intravenous patient-controlled analgesia for acute postoperative pain: a qualitative review of randomized trials.
Topics: Acute Disease; Analgesia, Patient-Controlled; Analgesics; Double-Blind Method; Drug Combinations; Hu | 2010 |
Adding ketamine to morphine for intravenous patient-controlled analgesia for acute postoperative pain: a qualitative review of randomized trials.
Topics: Acute Disease; Analgesia, Patient-Controlled; Analgesics; Double-Blind Method; Drug Combinations; Hu | 2010 |
Adding ketamine to morphine for intravenous patient-controlled analgesia for acute postoperative pain: a qualitative review of randomized trials.
Topics: Acute Disease; Analgesia, Patient-Controlled; Analgesics; Double-Blind Method; Drug Combinations; Hu | 2010 |
[Ketamine revisited].
Topics: Analgesics; Humans; Hyperalgesia; Ketamine; Pain, Postoperative | 2010 |
[Treatment of acute pain during drug-assisted rehabilitation].
Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents | 2010 |
The role of multimodal analgesia in pain management after ambulatory surgery.
Topics: Acetaminophen; Adrenergic alpha-2 Receptor Agonists; Adrenergic beta-1 Receptor Antagonists; Ambulat | 2010 |
Ketamine*.
Topics: Anesthesia; Anesthetics, Dissociative; Animals; Excitatory Amino Acid Antagonists; Humans; Ketamine; | 2011 |
Ketamine for perioperative pain management in children: a meta-analysis of published studies.
Topics: Adenoidectomy; Adolescent; Analgesia, Epidural; Analgesics, Opioid; Anesthesia, Caudal; Anesthesia, | 2011 |
A systematic review of intravenous ketamine for postoperative analgesia.
Topics: Analgesics; Humans; Infusions, Intravenous; Injections, Intravenous; Ketamine; Pain, Postoperative; | 2011 |
A systematic review of intravenous ketamine for postoperative analgesia.
Topics: Analgesics; Humans; Infusions, Intravenous; Injections, Intravenous; Ketamine; Pain, Postoperative; | 2011 |
A systematic review of intravenous ketamine for postoperative analgesia.
Topics: Analgesics; Humans; Infusions, Intravenous; Injections, Intravenous; Ketamine; Pain, Postoperative; | 2011 |
A systematic review of intravenous ketamine for postoperative analgesia.
Topics: Analgesics; Humans; Infusions, Intravenous; Injections, Intravenous; Ketamine; Pain, Postoperative; | 2011 |
A systematic review of intravenous ketamine for postoperative analgesia.
Topics: Analgesics; Humans; Infusions, Intravenous; Injections, Intravenous; Ketamine; Pain, Postoperative; | 2011 |
A systematic review of intravenous ketamine for postoperative analgesia.
Topics: Analgesics; Humans; Infusions, Intravenous; Injections, Intravenous; Ketamine; Pain, Postoperative; | 2011 |
A systematic review of intravenous ketamine for postoperative analgesia.
Topics: Analgesics; Humans; Infusions, Intravenous; Injections, Intravenous; Ketamine; Pain, Postoperative; | 2011 |
A systematic review of intravenous ketamine for postoperative analgesia.
Topics: Analgesics; Humans; Infusions, Intravenous; Injections, Intravenous; Ketamine; Pain, Postoperative; | 2011 |
A systematic review of intravenous ketamine for postoperative analgesia.
Topics: Analgesics; Humans; Infusions, Intravenous; Injections, Intravenous; Ketamine; Pain, Postoperative; | 2011 |
A systematic review of intravenous ketamine for postoperative analgesia.
Topics: Analgesics; Humans; Infusions, Intravenous; Injections, Intravenous; Ketamine; Pain, Postoperative; | 2011 |
A systematic review of intravenous ketamine for postoperative analgesia.
Topics: Analgesics; Humans; Infusions, Intravenous; Injections, Intravenous; Ketamine; Pain, Postoperative; | 2011 |
A systematic review of intravenous ketamine for postoperative analgesia.
Topics: Analgesics; Humans; Infusions, Intravenous; Injections, Intravenous; Ketamine; Pain, Postoperative; | 2011 |
A systematic review of intravenous ketamine for postoperative analgesia.
Topics: Analgesics; Humans; Infusions, Intravenous; Injections, Intravenous; Ketamine; Pain, Postoperative; | 2011 |
A systematic review of intravenous ketamine for postoperative analgesia.
Topics: Analgesics; Humans; Infusions, Intravenous; Injections, Intravenous; Ketamine; Pain, Postoperative; | 2011 |
A systematic review of intravenous ketamine for postoperative analgesia.
Topics: Analgesics; Humans; Infusions, Intravenous; Injections, Intravenous; Ketamine; Pain, Postoperative; | 2011 |
A systematic review of intravenous ketamine for postoperative analgesia.
Topics: Analgesics; Humans; Infusions, Intravenous; Injections, Intravenous; Ketamine; Pain, Postoperative; | 2011 |
A systematic review of intravenous ketamine for postoperative analgesia.
Topics: Analgesics; Humans; Infusions, Intravenous; Injections, Intravenous; Ketamine; Pain, Postoperative; | 2011 |
A systematic review of intravenous ketamine for postoperative analgesia.
Topics: Analgesics; Humans; Infusions, Intravenous; Injections, Intravenous; Ketamine; Pain, Postoperative; | 2011 |
A systematic review of intravenous ketamine for postoperative analgesia.
Topics: Analgesics; Humans; Infusions, Intravenous; Injections, Intravenous; Ketamine; Pain, Postoperative; | 2011 |
A systematic review of intravenous ketamine for postoperative analgesia.
Topics: Analgesics; Humans; Infusions, Intravenous; Injections, Intravenous; Ketamine; Pain, Postoperative; | 2011 |
A systematic review of intravenous ketamine for postoperative analgesia.
Topics: Analgesics; Humans; Infusions, Intravenous; Injections, Intravenous; Ketamine; Pain, Postoperative; | 2011 |
A systematic review of intravenous ketamine for postoperative analgesia.
Topics: Analgesics; Humans; Infusions, Intravenous; Injections, Intravenous; Ketamine; Pain, Postoperative; | 2011 |
A systematic review of intravenous ketamine for postoperative analgesia.
Topics: Analgesics; Humans; Infusions, Intravenous; Injections, Intravenous; Ketamine; Pain, Postoperative; | 2011 |
A systematic review of intravenous ketamine for postoperative analgesia.
Topics: Analgesics; Humans; Infusions, Intravenous; Injections, Intravenous; Ketamine; Pain, Postoperative; | 2011 |
A systematic review of intravenous ketamine for postoperative analgesia.
Topics: Analgesics; Humans; Infusions, Intravenous; Injections, Intravenous; Ketamine; Pain, Postoperative; | 2011 |
Efficacy and adverse effects of ketamine as an additive for paediatric caudal anaesthesia: a quantitative systematic review of randomized controlled trials.
Topics: Abdomen; Anesthesia, Caudal; Anesthetics, Dissociative; Anesthetics, Local; Child; Child, Preschool; | 2011 |
Does adding ketamine to morphine patient-controlled analgesia safely improve post-thoracotomy pain?
Topics: Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Benchmarking; Evidence-Based Medicine | 2012 |
Does adding ketamine to morphine patient-controlled analgesia safely improve post-thoracotomy pain?
Topics: Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Benchmarking; Evidence-Based Medicine | 2012 |
Does adding ketamine to morphine patient-controlled analgesia safely improve post-thoracotomy pain?
Topics: Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Benchmarking; Evidence-Based Medicine | 2012 |
Does adding ketamine to morphine patient-controlled analgesia safely improve post-thoracotomy pain?
Topics: Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Benchmarking; Evidence-Based Medicine | 2012 |
Does adding ketamine to morphine patient-controlled analgesia safely improve post-thoracotomy pain?
Topics: Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Benchmarking; Evidence-Based Medicine | 2012 |
Does adding ketamine to morphine patient-controlled analgesia safely improve post-thoracotomy pain?
Topics: Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Benchmarking; Evidence-Based Medicine | 2012 |
Does adding ketamine to morphine patient-controlled analgesia safely improve post-thoracotomy pain?
Topics: Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Benchmarking; Evidence-Based Medicine | 2012 |
Does adding ketamine to morphine patient-controlled analgesia safely improve post-thoracotomy pain?
Topics: Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Benchmarking; Evidence-Based Medicine | 2012 |
Does adding ketamine to morphine patient-controlled analgesia safely improve post-thoracotomy pain?
Topics: Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Benchmarking; Evidence-Based Medicine | 2012 |
Does adding ketamine to morphine patient-controlled analgesia safely improve post-thoracotomy pain?
Topics: Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Benchmarking; Evidence-Based Medicine | 2012 |
Does adding ketamine to morphine patient-controlled analgesia safely improve post-thoracotomy pain?
Topics: Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Benchmarking; Evidence-Based Medicine | 2012 |
Does adding ketamine to morphine patient-controlled analgesia safely improve post-thoracotomy pain?
Topics: Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Benchmarking; Evidence-Based Medicine | 2012 |
Does adding ketamine to morphine patient-controlled analgesia safely improve post-thoracotomy pain?
Topics: Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Benchmarking; Evidence-Based Medicine | 2012 |
Does adding ketamine to morphine patient-controlled analgesia safely improve post-thoracotomy pain?
Topics: Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Benchmarking; Evidence-Based Medicine | 2012 |
Does adding ketamine to morphine patient-controlled analgesia safely improve post-thoracotomy pain?
Topics: Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Benchmarking; Evidence-Based Medicine | 2012 |
Does adding ketamine to morphine patient-controlled analgesia safely improve post-thoracotomy pain?
Topics: Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Benchmarking; Evidence-Based Medicine | 2012 |
[Prevention of postoperative hyperalgesia].
Topics: Amantadine; Amines; Analgesics, Non-Narcotic; Analgesics, Opioid; Cyclohexanecarboxylic Acids; Excit | 2012 |
Non-opioid IV adjuvants in the perioperative period: pharmacological and clinical aspects of ketamine and gabapentinoids.
Topics: Adjuvants, Pharmaceutic; Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Gabapentin; gamma | 2012 |
Pharmacology of systemic analgesics.
Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Dipyr | 2002 |
Overview of pharmacological aspects of sedation--Part I.
Topics: Analgesics; Anesthesia, Dental; Child; Chloral Hydrate; Conscious Sedation; Dental Anxiety; Humans; | 2000 |
Ketamine, revival of a versatile intravenous anaesthetic.
Topics: Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Dissociative; Anesthetics, Intravenous; H | 2003 |
A qualitative systematic review of the role of N-methyl-D-aspartate receptor antagonists in preventive analgesia.
Topics: Analgesics, Opioid; Anesthetics, Dissociative; Clinical Trials as Topic; Dextromethorphan; Excitator | 2004 |
Ketamine for perioperative pain management.
Topics: Analgesia; Anesthesia, Conduction; Anesthesia, General; Anesthetics, Dissociative; Humans; Ketamine; | 2005 |
Ketamine for perioperative pain management.
Topics: Analgesia; Anesthesia, Conduction; Anesthesia, General; Anesthetics, Dissociative; Humans; Ketamine; | 2005 |
Ketamine for perioperative pain management.
Topics: Analgesia; Anesthesia, Conduction; Anesthesia, General; Anesthetics, Dissociative; Humans; Ketamine; | 2005 |
Ketamine for perioperative pain management.
Topics: Analgesia; Anesthesia, Conduction; Anesthesia, General; Anesthetics, Dissociative; Humans; Ketamine; | 2005 |
Ketamine and postoperative pain--a quantitative systematic review of randomised trials.
Topics: Adult; Age Factors; Analgesics; Child; Drug Administration Routes; Hallucinations; Humans; Ketamine; | 2005 |
Ketamine and postoperative pain--a quantitative systematic review of randomised trials.
Topics: Adult; Age Factors; Analgesics; Child; Drug Administration Routes; Hallucinations; Humans; Ketamine; | 2005 |
Ketamine and postoperative pain--a quantitative systematic review of randomised trials.
Topics: Adult; Age Factors; Analgesics; Child; Drug Administration Routes; Hallucinations; Humans; Ketamine; | 2005 |
Ketamine and postoperative pain--a quantitative systematic review of randomised trials.
Topics: Adult; Age Factors; Analgesics; Child; Drug Administration Routes; Hallucinations; Humans; Ketamine; | 2005 |
Ketamine and postoperative pain--a quantitative systematic review of randomised trials.
Topics: Adult; Age Factors; Analgesics; Child; Drug Administration Routes; Hallucinations; Humans; Ketamine; | 2005 |
Ketamine and postoperative pain--a quantitative systematic review of randomised trials.
Topics: Adult; Age Factors; Analgesics; Child; Drug Administration Routes; Hallucinations; Humans; Ketamine; | 2005 |
Ketamine and postoperative pain--a quantitative systematic review of randomised trials.
Topics: Adult; Age Factors; Analgesics; Child; Drug Administration Routes; Hallucinations; Humans; Ketamine; | 2005 |
Ketamine and postoperative pain--a quantitative systematic review of randomised trials.
Topics: Adult; Age Factors; Analgesics; Child; Drug Administration Routes; Hallucinations; Humans; Ketamine; | 2005 |
Ketamine and postoperative pain--a quantitative systematic review of randomised trials.
Topics: Adult; Age Factors; Analgesics; Child; Drug Administration Routes; Hallucinations; Humans; Ketamine; | 2005 |
Ketamine and postoperative pain--a quantitative systematic review of randomised trials.
Topics: Adult; Age Factors; Analgesics; Child; Drug Administration Routes; Hallucinations; Humans; Ketamine; | 2005 |
Ketamine and postoperative pain--a quantitative systematic review of randomised trials.
Topics: Adult; Age Factors; Analgesics; Child; Drug Administration Routes; Hallucinations; Humans; Ketamine; | 2005 |
Ketamine and postoperative pain--a quantitative systematic review of randomised trials.
Topics: Adult; Age Factors; Analgesics; Child; Drug Administration Routes; Hallucinations; Humans; Ketamine; | 2005 |
Ketamine and postoperative pain--a quantitative systematic review of randomised trials.
Topics: Adult; Age Factors; Analgesics; Child; Drug Administration Routes; Hallucinations; Humans; Ketamine; | 2005 |
Ketamine and postoperative pain--a quantitative systematic review of randomised trials.
Topics: Adult; Age Factors; Analgesics; Child; Drug Administration Routes; Hallucinations; Humans; Ketamine; | 2005 |
Ketamine and postoperative pain--a quantitative systematic review of randomised trials.
Topics: Adult; Age Factors; Analgesics; Child; Drug Administration Routes; Hallucinations; Humans; Ketamine; | 2005 |
Ketamine and postoperative pain--a quantitative systematic review of randomised trials.
Topics: Adult; Age Factors; Analgesics; Child; Drug Administration Routes; Hallucinations; Humans; Ketamine; | 2005 |
Peri-operative ketamine for acute post-operative pain: a quantitative and qualitative systematic review (Cochrane review).
Topics: Adult; Aged; Analgesics, Opioid; Anesthetics, Dissociative; Data Interpretation, Statistical; Drug T | 2005 |
Peri-operative ketamine for acute post-operative pain: a quantitative and qualitative systematic review (Cochrane review).
Topics: Adult; Aged; Analgesics, Opioid; Anesthetics, Dissociative; Data Interpretation, Statistical; Drug T | 2005 |
Peri-operative ketamine for acute post-operative pain: a quantitative and qualitative systematic review (Cochrane review).
Topics: Adult; Aged; Analgesics, Opioid; Anesthetics, Dissociative; Data Interpretation, Statistical; Drug T | 2005 |
Peri-operative ketamine for acute post-operative pain: a quantitative and qualitative systematic review (Cochrane review).
Topics: Adult; Aged; Analgesics, Opioid; Anesthetics, Dissociative; Data Interpretation, Statistical; Drug T | 2005 |
Peri-operative ketamine for acute post-operative pain: a quantitative and qualitative systematic review (Cochrane review).
Topics: Adult; Aged; Analgesics, Opioid; Anesthetics, Dissociative; Data Interpretation, Statistical; Drug T | 2005 |
Peri-operative ketamine for acute post-operative pain: a quantitative and qualitative systematic review (Cochrane review).
Topics: Adult; Aged; Analgesics, Opioid; Anesthetics, Dissociative; Data Interpretation, Statistical; Drug T | 2005 |
Peri-operative ketamine for acute post-operative pain: a quantitative and qualitative systematic review (Cochrane review).
Topics: Adult; Aged; Analgesics, Opioid; Anesthetics, Dissociative; Data Interpretation, Statistical; Drug T | 2005 |
Peri-operative ketamine for acute post-operative pain: a quantitative and qualitative systematic review (Cochrane review).
Topics: Adult; Aged; Analgesics, Opioid; Anesthetics, Dissociative; Data Interpretation, Statistical; Drug T | 2005 |
Peri-operative ketamine for acute post-operative pain: a quantitative and qualitative systematic review (Cochrane review).
Topics: Adult; Aged; Analgesics, Opioid; Anesthetics, Dissociative; Data Interpretation, Statistical; Drug T | 2005 |
Ketamine: new indications for an old drug.
Topics: Anesthesia; Anesthesia, Local; Anesthetics, Dissociative; Humans; Ketamine; Pain, Postoperative; Rec | 2005 |
Perioperative ketamine for acute postoperative pain.
Topics: Analgesics; Humans; Infusions, Intravenous; Ketamine; Pain, Postoperative; Postoperative Nausea and | 2006 |
Perioperative ketamine for acute postoperative pain.
Topics: Analgesics; Humans; Infusions, Intravenous; Ketamine; Pain, Postoperative; Postoperative Nausea and | 2006 |
Perioperative ketamine for acute postoperative pain.
Topics: Analgesics; Humans; Infusions, Intravenous; Ketamine; Pain, Postoperative; Postoperative Nausea and | 2006 |
Perioperative ketamine for acute postoperative pain.
Topics: Analgesics; Humans; Infusions, Intravenous; Ketamine; Pain, Postoperative; Postoperative Nausea and | 2006 |
Perioperative ketamine for acute postoperative pain.
Topics: Analgesics; Humans; Infusions, Intravenous; Ketamine; Pain, Postoperative; Postoperative Nausea and | 2006 |
Perioperative ketamine for acute postoperative pain.
Topics: Analgesics; Humans; Infusions, Intravenous; Ketamine; Pain, Postoperative; Postoperative Nausea and | 2006 |
Perioperative ketamine for acute postoperative pain.
Topics: Analgesics; Humans; Infusions, Intravenous; Ketamine; Pain, Postoperative; Postoperative Nausea and | 2006 |
Perioperative ketamine for acute postoperative pain.
Topics: Analgesics; Humans; Infusions, Intravenous; Ketamine; Pain, Postoperative; Postoperative Nausea and | 2006 |
Perioperative ketamine for acute postoperative pain.
Topics: Analgesics; Humans; Infusions, Intravenous; Ketamine; Pain, Postoperative; Postoperative Nausea and | 2006 |
Systemic analgesia and co-analgesia.
Topics: Amines; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Cyclohexanecarboxylic Acids; Dexme | 2006 |
Useful adjuvants for postoperative pain management.
Topics: Amines; Clonidine; Cyclohexanecarboxylic Acids; Dexamethasone; Excitatory Amino Acid Antagonists; Ga | 2007 |
The clinical role of NMDA receptor antagonists for the treatment of postoperative pain.
Topics: Drug Tolerance; Excitatory Amino Acid Antagonists; Humans; Hyperalgesia; Ketamine; Pain, Postoperati | 2007 |
The clinical role of NMDA receptor antagonists for the treatment of postoperative pain.
Topics: Drug Tolerance; Excitatory Amino Acid Antagonists; Humans; Hyperalgesia; Ketamine; Pain, Postoperati | 2007 |
The clinical role of NMDA receptor antagonists for the treatment of postoperative pain.
Topics: Drug Tolerance; Excitatory Amino Acid Antagonists; Humans; Hyperalgesia; Ketamine; Pain, Postoperati | 2007 |
The clinical role of NMDA receptor antagonists for the treatment of postoperative pain.
Topics: Drug Tolerance; Excitatory Amino Acid Antagonists; Humans; Hyperalgesia; Ketamine; Pain, Postoperati | 2007 |
Preventing the development of chronic pain after orthopaedic surgery with preventive multimodal analgesic techniques.
Topics: Acetaminophen; Adrenergic alpha-Agonists; Analgesia, Epidural; Analgesics; Anesthetics, Local; Anima | 2007 |
The effect of analgesic technique on postoperative patient-reported outcomes including analgesia: a systematic review.
Topics: Acetaminophen; Amines; Analgesia; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics; An | 2007 |
The effect of analgesic technique on postoperative patient-reported outcomes including analgesia: a systematic review.
Topics: Acetaminophen; Amines; Analgesia; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics; An | 2007 |
The effect of analgesic technique on postoperative patient-reported outcomes including analgesia: a systematic review.
Topics: Acetaminophen; Amines; Analgesia; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics; An | 2007 |
The effect of analgesic technique on postoperative patient-reported outcomes including analgesia: a systematic review.
Topics: Acetaminophen; Amines; Analgesia; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics; An | 2007 |
[Drugs for postoperative analgesia: routine and new aspects: Part 2: opioids, ketamine and gabapentinoids].
Topics: Adjuvants, Pharmaceutic; Amines; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthetics, Dissocia | 2008 |
[Ketamine].
Topics: Adolescent; Adult; Aged; Ambulatory Surgical Procedures; Analgesics; Anesthesia, Intravenous; Anesth | 1999 |
Use and efficacy of low-dose ketamine in the management of acute postoperative pain: a review of current techniques and outcomes.
Topics: Analgesia, Epidural; Analgesics; Dose-Response Relationship, Drug; Humans; Injections, Intramuscular | 1999 |
Use and efficacy of low-dose ketamine in the management of acute postoperative pain: a review of current techniques and outcomes.
Topics: Analgesia, Epidural; Analgesics; Dose-Response Relationship, Drug; Humans; Injections, Intramuscular | 1999 |
Use and efficacy of low-dose ketamine in the management of acute postoperative pain: a review of current techniques and outcomes.
Topics: Analgesia, Epidural; Analgesics; Dose-Response Relationship, Drug; Humans; Injections, Intramuscular | 1999 |
Use and efficacy of low-dose ketamine in the management of acute postoperative pain: a review of current techniques and outcomes.
Topics: Analgesia, Epidural; Analgesics; Dose-Response Relationship, Drug; Humans; Injections, Intramuscular | 1999 |
Use and efficacy of low-dose ketamine in the management of acute postoperative pain: a review of current techniques and outcomes.
Topics: Analgesia, Epidural; Analgesics; Dose-Response Relationship, Drug; Humans; Injections, Intramuscular | 1999 |
Use and efficacy of low-dose ketamine in the management of acute postoperative pain: a review of current techniques and outcomes.
Topics: Analgesia, Epidural; Analgesics; Dose-Response Relationship, Drug; Humans; Injections, Intramuscular | 1999 |
Use and efficacy of low-dose ketamine in the management of acute postoperative pain: a review of current techniques and outcomes.
Topics: Analgesia, Epidural; Analgesics; Dose-Response Relationship, Drug; Humans; Injections, Intramuscular | 1999 |
Use and efficacy of low-dose ketamine in the management of acute postoperative pain: a review of current techniques and outcomes.
Topics: Analgesia, Epidural; Analgesics; Dose-Response Relationship, Drug; Humans; Injections, Intramuscular | 1999 |
Use and efficacy of low-dose ketamine in the management of acute postoperative pain: a review of current techniques and outcomes.
Topics: Analgesia, Epidural; Analgesics; Dose-Response Relationship, Drug; Humans; Injections, Intramuscular | 1999 |
Use and efficacy of low-dose ketamine in the management of acute postoperative pain: a review of current techniques and outcomes.
Topics: Analgesia, Epidural; Analgesics; Dose-Response Relationship, Drug; Humans; Injections, Intramuscular | 1999 |
Use and efficacy of low-dose ketamine in the management of acute postoperative pain: a review of current techniques and outcomes.
Topics: Analgesia, Epidural; Analgesics; Dose-Response Relationship, Drug; Humans; Injections, Intramuscular | 1999 |
Use and efficacy of low-dose ketamine in the management of acute postoperative pain: a review of current techniques and outcomes.
Topics: Analgesia, Epidural; Analgesics; Dose-Response Relationship, Drug; Humans; Injections, Intramuscular | 1999 |
Use and efficacy of low-dose ketamine in the management of acute postoperative pain: a review of current techniques and outcomes.
Topics: Analgesia, Epidural; Analgesics; Dose-Response Relationship, Drug; Humans; Injections, Intramuscular | 1999 |
Use and efficacy of low-dose ketamine in the management of acute postoperative pain: a review of current techniques and outcomes.
Topics: Analgesia, Epidural; Analgesics; Dose-Response Relationship, Drug; Humans; Injections, Intramuscular | 1999 |
Use and efficacy of low-dose ketamine in the management of acute postoperative pain: a review of current techniques and outcomes.
Topics: Analgesia, Epidural; Analgesics; Dose-Response Relationship, Drug; Humans; Injections, Intramuscular | 1999 |
Use and efficacy of low-dose ketamine in the management of acute postoperative pain: a review of current techniques and outcomes.
Topics: Analgesia, Epidural; Analgesics; Dose-Response Relationship, Drug; Humans; Injections, Intramuscular | 1999 |
Use and efficacy of low-dose ketamine in the management of acute postoperative pain: a review of current techniques and outcomes.
Topics: Analgesia, Epidural; Analgesics; Dose-Response Relationship, Drug; Humans; Injections, Intramuscular | 1999 |
Use and efficacy of low-dose ketamine in the management of acute postoperative pain: a review of current techniques and outcomes.
Topics: Analgesia, Epidural; Analgesics; Dose-Response Relationship, Drug; Humans; Injections, Intramuscular | 1999 |
Use and efficacy of low-dose ketamine in the management of acute postoperative pain: a review of current techniques and outcomes.
Topics: Analgesia, Epidural; Analgesics; Dose-Response Relationship, Drug; Humans; Injections, Intramuscular | 1999 |
Use and efficacy of low-dose ketamine in the management of acute postoperative pain: a review of current techniques and outcomes.
Topics: Analgesia, Epidural; Analgesics; Dose-Response Relationship, Drug; Humans; Injections, Intramuscular | 1999 |
Use and efficacy of low-dose ketamine in the management of acute postoperative pain: a review of current techniques and outcomes.
Topics: Analgesia, Epidural; Analgesics; Dose-Response Relationship, Drug; Humans; Injections, Intramuscular | 1999 |
Use and efficacy of low-dose ketamine in the management of acute postoperative pain: a review of current techniques and outcomes.
Topics: Analgesia, Epidural; Analgesics; Dose-Response Relationship, Drug; Humans; Injections, Intramuscular | 1999 |
Use and efficacy of low-dose ketamine in the management of acute postoperative pain: a review of current techniques and outcomes.
Topics: Analgesia, Epidural; Analgesics; Dose-Response Relationship, Drug; Humans; Injections, Intramuscular | 1999 |
Use and efficacy of low-dose ketamine in the management of acute postoperative pain: a review of current techniques and outcomes.
Topics: Analgesia, Epidural; Analgesics; Dose-Response Relationship, Drug; Humans; Injections, Intramuscular | 1999 |
Use and efficacy of low-dose ketamine in the management of acute postoperative pain: a review of current techniques and outcomes.
Topics: Analgesia, Epidural; Analgesics; Dose-Response Relationship, Drug; Humans; Injections, Intramuscular | 1999 |
[Management of postoperative pain in pediatrics].
Topics: Adolescent; Analgesia, Epidural; Analgesia, Patient-Controlled; Anti-Inflammatory Agents, Non-Steroi | 2000 |
Interactions between systemic analgesics.
Topics: Acetaminophen; Adrenergic alpha-Agonists; Analgesia; Analgesics; Anti-Inflammatory Agents, Non-Stero | 2001 |
The role of non-opioid analgesic techniques in the management of pain after ambulatory surgery.
Topics: Acetaminophen; Ambulatory Surgical Procedures; Analgesics, Non-Narcotic; Anesthetics, Local; Anti-In | 2002 |
The role of non-opioid analgesic techniques in the management of pain after ambulatory surgery.
Topics: Acetaminophen; Ambulatory Surgical Procedures; Analgesics, Non-Narcotic; Anesthetics, Local; Anti-In | 2002 |
The role of non-opioid analgesic techniques in the management of pain after ambulatory surgery.
Topics: Acetaminophen; Ambulatory Surgical Procedures; Analgesics, Non-Narcotic; Anesthetics, Local; Anti-In | 2002 |
The role of non-opioid analgesic techniques in the management of pain after ambulatory surgery.
Topics: Acetaminophen; Ambulatory Surgical Procedures; Analgesics, Non-Narcotic; Anesthetics, Local; Anti-In | 2002 |
The pharmacological management of postoperative pain.
Topics: Analgesics; Anesthetics, Local; Central Nervous System; Child; Drug Therapy, Combination; Humans; Ke | 1977 |
392 trials available for ketamine and Pain, Postoperative
| Article | Year |
|---|---|
The impact of bolus versus continuous infusion of intravenous ketamine on bispectral index variations and desflurane administration during major surgery: The KETABIS study.
Topics: Desflurane; Double-Blind Method; Humans; Ketamine; Pain, Postoperative; Piperidines; Prospective Stu | 2021 |
The effect of low-dose ketamine on postoperative quality of recovery in patients undergoing breast cancer surgery: A randomised, placebo-controlled trial.
Topics: Analgesics, Opioid; Breast Neoplasms; Double-Blind Method; Female; Humans; Ketamine; Mastectomy; Pai | 2021 |
Perioperative intravenous S(+)-ketamine for acute postoperative pain in adults: study protocol for a multicentre, randomised, open-label, positive-controlled, pragmatic clinical trial (SAFE-SK-A trial).
Topics: Adult; Analgesics; Analgesics, Opioid; Humans; Ketamine; Multicenter Studies as Topic; Pain Measurem | 2021 |
Comparison of Combination Between Ketamine and Parecoxib as Multimodal Preemptive Analgesia With Ketamine Alone for Elective Laparotomy.
Topics: Analgesia, Patient-Controlled; Humans; Isoxazoles; Ketamine; Laparotomy; Pain, Postoperative; Prospe | 2021 |
Combined opioid free and loco-regional anaesthesia enhances the quality of recovery in sleeve gastrectomy done under ERAS protocol: a randomized controlled trial.
Topics: Adult; Anesthesia, Conduction; Anesthesia, Local; Anesthetics, Dissociative; Anesthetics, Intravenou | 2022 |
Combined opioid free and loco-regional anaesthesia enhances the quality of recovery in sleeve gastrectomy done under ERAS protocol: a randomized controlled trial.
Topics: Adult; Anesthesia, Conduction; Anesthesia, Local; Anesthetics, Dissociative; Anesthetics, Intravenou | 2022 |
Combined opioid free and loco-regional anaesthesia enhances the quality of recovery in sleeve gastrectomy done under ERAS protocol: a randomized controlled trial.
Topics: Adult; Anesthesia, Conduction; Anesthesia, Local; Anesthetics, Dissociative; Anesthetics, Intravenou | 2022 |
Combined opioid free and loco-regional anaesthesia enhances the quality of recovery in sleeve gastrectomy done under ERAS protocol: a randomized controlled trial.
Topics: Adult; Anesthesia, Conduction; Anesthesia, Local; Anesthetics, Dissociative; Anesthetics, Intravenou | 2022 |
Evaluation of intraoperative ketamine on the prevention of severe rebound pain upon cessation of peripheral nerve block: a prospective randomised, double-blind, placebo-controlled study.
Topics: Double-Blind Method; Humans; Ketamine; Pain, Postoperative; Peripheral Nerves; Prospective Studies | 2022 |
Evaluation of intraoperative ketamine on the prevention of severe rebound pain upon cessation of peripheral nerve block: a prospective randomised, double-blind, placebo-controlled study.
Topics: Double-Blind Method; Humans; Ketamine; Pain, Postoperative; Peripheral Nerves; Prospective Studies | 2022 |
Evaluation of intraoperative ketamine on the prevention of severe rebound pain upon cessation of peripheral nerve block: a prospective randomised, double-blind, placebo-controlled study.
Topics: Double-Blind Method; Humans; Ketamine; Pain, Postoperative; Peripheral Nerves; Prospective Studies | 2022 |
Evaluation of intraoperative ketamine on the prevention of severe rebound pain upon cessation of peripheral nerve block: a prospective randomised, double-blind, placebo-controlled study.
Topics: Double-Blind Method; Humans; Ketamine; Pain, Postoperative; Peripheral Nerves; Prospective Studies | 2022 |
Comparison of Ketamine, Dexmedetomidine and Lidocaine in Multimodal Analgesia Management Following Sleeve Gastrectomy Surgery: A Randomized Double-Blind Trial.
Topics: Analgesia; Anesthetics, Local; Dexmedetomidine; Double-Blind Method; Gastrectomy; Humans; Ketamine; | 2022 |
Subanaesthetic dose of esketamine during induction delays anaesthesia recovery a randomized, double-blind clinical trial.
Topics: Anesthesia, General; Double-Blind Method; Humans; Ketamine; Pain, Postoperative; Postoperative Nause | 2022 |
Effect of S-ketamine on Postoperative Quality of Recovery in Patients Undergoing Video-Assisted Thoracic Surgery.
Topics: Adult; Analgesics, Opioid; Double-Blind Method; Humans; Ketamine; Pain, Postoperative; Prospective S | 2022 |
Effect of a single sub-dose of ketamine on postoperative fatigue syndrome in colorectal cancer patients undergoing radical laparoscopic surgery: A double-blind, pilot study.
Topics: Anesthetics; Colorectal Neoplasms; Double-Blind Method; Fatigue; Humans; Interleukin-6; Ketamine; La | 2022 |
Comparing Effect of Adding Ketamine Versus Dexmedetomidine to Bupivacaine in Pecs-ⅠⅠ Block on Postoperative Pain Control in Patients Undergoing Breast Surgery.
Topics: Anesthetics, Local; Breast Neoplasms; Bupivacaine; Dexmedetomidine; Double-Blind Method; Female; Hum | 2022 |
No Benefits of Adding Dexmedetomidine, Ketamine, Dexamethasone, and Nerve Blocks to an Established Multimodal Analgesic Regimen after Total Knee Arthroplasty.
Topics: Analgesics; Analgesics, Opioid; Anesthetics, Local; Arthroplasty, Replacement, Knee; Dexamethasone; | 2022 |
Evaluation of the effect of perioperative administration of S(+)-ketamine hydrochloride injection for postoperative acute pain in children: study protocol for a prospective, multicenter, randomized, open-label, parallel-group, pragmatic clinical trial.
Topics: Acute Pain; Adolescent; Analgesics; Analgesics, Opioid; Child; Child, Preschool; Humans; Infant; Inf | 2022 |
Ketamine for acute pain after trauma: the KAPT randomized controlled trial.
Topics: Acute Pain; Adult; Analgesics; Analgesics, Opioid; Humans; Ketamine; Pain Measurement; Pain, Postope | 2022 |
Randomized clinical trial comparing outcomes after fentanyl or ketamine-dexmedetomidine analgesia in thoracolumbar spinal surgery in dogs.
Topics: Analgesia; Analgesics, Opioid; Animals; Dexmedetomidine; Dog Diseases; Dogs; Fentanyl; Intervertebra | 2022 |
The efficacy and safety of an adapted opioid-free anesthesia regimen versus conventional general anesthesia in gynecological surgery for low-resource settings: a randomized pilot study.
Topics: Analgesics, Opioid; Anesthesia, General; Clonidine; Dexamethasone; Dexmedetomidine; Diazepam; Female | 2022 |
Effect of Intranasal Ketamine on Pain Intensity after Cesarean Section: A Single-Center, Double Blind, Randomized Controlled Trial.
Topics: Analgesics; Analgesics, Opioid; Cesarean Section; Double-Blind Method; Female; Humans; Ketamine; Nau | 2023 |
Randomised, prospective, blinded, clinical trial of opioid-free injectable anaesthesia with or without multimodal analgesia in kittens undergoing ovariohysterectomy.
Topics: Analgesics, Opioid; Anesthesia; Animals; Bupivacaine; Cats; Dexmedetomidine; Eating; Female; Hystere | 2023 |
Perioperative use of ketamine infusion versus dexmedetomidine infusion for analgesia in obese patients undergoing bariatric surgery: a double-blinded three-armed randomized controlled trial.
Topics: Analgesia; Analgesics, Opioid; Bariatric Surgery; Dexmedetomidine; Double-Blind Method; Fentanyl; Hu | 2023 |
Effects of the Different Doses of Esketamine on Postoperative Quality of Recovery in Patients Undergoing Modified Radical Mastectomy: A Randomized, Double-Blind, Controlled Trial [Letter].
Topics: Breast Neoplasms; Double-Blind Method; Female; Humans; Ketamine; Mastectomy; Mastectomy, Modified Ra | 2023 |
Effect of subanesthetic dose of esketamine on postoperative rehabilitation in elderly patients undergoing hip arthroplasty.
Topics: Aged; Analgesia, Patient-Controlled; Arthroplasty, Replacement, Hip; Dizziness; Femoral Neck Fractur | 2023 |
Intraoperative intravenous low-dose esketamine improves quality of early recovery after laparoscopic radical resection of colorectal cancer: A prospective, randomized controlled trial.
Topics: Colorectal Neoplasms; Double-Blind Method; Humans; Ketamine; Laparoscopy; Pain, Postoperative; Prosp | 2023 |
Mini-dose esketamine-dexmedetomidine combination to supplement analgesia for patients after scoliosis correction surgery: a double-blind randomised trial.
Topics: Adult; Analgesia; Dexmedetomidine; Double-Blind Method; Female; Humans; Ketamine; Male; Pain, Postop | 2023 |
Effects of intraoperative esketamine addition on gastrointestinal function after benign gynaecological laparoscopic surgery: a double-blind, randomized controlled study.
Topics: Analgesics, Opioid; Double-Blind Method; Female; Flatulence; Gynecologic Surgical Procedures; Humans | 2023 |
Preoperative Esketamine Alleviates Postoperative Pain after Endoscopic Plasma Adenotonsillectomy in Children.
Topics: Adenoidectomy; Child; Humans; Ketamine; Pain, Postoperative; Tonsillectomy | 2023 |
Subcutaneous wound infiltration of ketamine is superior to bupivacaine in terms of pain perception and opioid consumption after cesarean section: a double-blinded randomized placebo-controlled clinical trial.
Topics: Analgesics; Analgesics, Opioid; Anesthetics, Local; Bupivacaine; Cesarean Section; Double-Blind Meth | 2023 |
Assessing the effectiveness of perioperative s-ketamine on new-onset headache after resective epilepsy surgery (ESPAIN-trial): protocol for a randomised, double-blind, placebo-controlled trial.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Double-Blind Method; Drug Combinations; | 2019 |
Intraoperative Ketamine for Analgesia Post-Coronary Artery Bypass Surgery: A Randomized, Controlled, Double-Blind Clinical Trial.
Topics: Analgesia; Analgesics, Opioid; Coronary Artery Bypass; Double-Blind Method; Humans; Ketamine; Morphi | 2020 |
Perioperative intravenous low-dose ketamine for neuropathic pain after major lower back surgery: A randomized, placebo-controlled study.
Topics: Adult; Analgesics; Double-Blind Method; Humans; Infusions, Intravenous; Ketamine; Neuralgia; Pain Me | 2020 |
Opioid-sparing effect of a medetomidine constant rate infusion during thoraco-lumbar hemilaminectomy in dogs administered a ketamine infusion.
Topics: Analgesics; Analgesics, Opioid; Anesthesia; Animals; Dogs; Drug Therapy, Combination; Female; Fentan | 2020 |
Magnesium and Ketamine Reduce Early Morphine Consumption After Open Bariatric Surgery: a Prospective Randomized Double-Blind Study.
Topics: Analgesics; Analgesics, Opioid; Bariatric Surgery; Double-Blind Method; Humans; Ketamine; Magnesium; | 2020 |
Effect of Pretreatment of S-Ketamine On Postoperative Depression for Breast Cancer Patients.
Topics: Breast Neoplasms; Depression; Double-Blind Method; Female; Humans; Ketamine; Pain, Postoperative | 2021 |
Effects of Intraoperative Low-Dose Ketamine on Persistent Postsurgical Pain after Breast Cancer Surgery: A Prospective, Randomized, Controlled, Double-Blind Study.
Topics: Adult; Analgesics; Breast Neoplasms; Chronic Pain; Double-Blind Method; Female; Humans; Ketamine; Ma | 2020 |
The efficacy of ketamine for postoperative pain control in adolescent patients undergoing spinal fusion surgery for idiopathic scoliosis.
Topics: Analgesics; Child; Double-Blind Method; Drug Therapy, Combination; Drug Utilization; Female; Humans; | 2020 |
Intra-operative low-dose ketamine does not reduce the cost of post-operative pain management after surgery: a randomized controlled trial in a low-income country.
Topics: Adult; Analgesics; Analgesics, Opioid; Cost-Benefit Analysis; Double-Blind Method; Female; Humans; K | 2019 |
Analgesia for adenotonsillectomy in children: a comparison between peritonsillar infiltration of tramadol, ketamine, and placebo.
Topics: Adenoidectomy; Adolescent; Analgesia; Analgesics, Opioid; Child; Child, Preschool; Double-Blind Meth | 2020 |
Analgesic Effect of Intraoperative Intravenous S-Ketamine in Opioid-Naïve Patients After Major Lumbar Fusion Surgery Is Temporary and Not Dose-Dependent: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.
Topics: Administration, Intravenous; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Dose-Response Relat | 2021 |
Analgesic Effect of Intraoperative Intravenous S-Ketamine in Opioid-Naïve Patients After Major Lumbar Fusion Surgery Is Temporary and Not Dose-Dependent: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.
Topics: Administration, Intravenous; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Dose-Response Relat | 2021 |
Analgesic Effect of Intraoperative Intravenous S-Ketamine in Opioid-Naïve Patients After Major Lumbar Fusion Surgery Is Temporary and Not Dose-Dependent: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.
Topics: Administration, Intravenous; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Dose-Response Relat | 2021 |
Analgesic Effect of Intraoperative Intravenous S-Ketamine in Opioid-Naïve Patients After Major Lumbar Fusion Surgery Is Temporary and Not Dose-Dependent: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.
Topics: Administration, Intravenous; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Dose-Response Relat | 2021 |
Analgesic Effect of Intraoperative Intravenous S-Ketamine in Opioid-Naïve Patients After Major Lumbar Fusion Surgery Is Temporary and Not Dose-Dependent: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.
Topics: Administration, Intravenous; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Dose-Response Relat | 2021 |
Analgesic Effect of Intraoperative Intravenous S-Ketamine in Opioid-Naïve Patients After Major Lumbar Fusion Surgery Is Temporary and Not Dose-Dependent: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.
Topics: Administration, Intravenous; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Dose-Response Relat | 2021 |
Analgesic Effect of Intraoperative Intravenous S-Ketamine in Opioid-Naïve Patients After Major Lumbar Fusion Surgery Is Temporary and Not Dose-Dependent: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.
Topics: Administration, Intravenous; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Dose-Response Relat | 2021 |
Analgesic Effect of Intraoperative Intravenous S-Ketamine in Opioid-Naïve Patients After Major Lumbar Fusion Surgery Is Temporary and Not Dose-Dependent: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.
Topics: Administration, Intravenous; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Dose-Response Relat | 2021 |
Analgesic Effect of Intraoperative Intravenous S-Ketamine in Opioid-Naïve Patients After Major Lumbar Fusion Surgery Is Temporary and Not Dose-Dependent: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.
Topics: Administration, Intravenous; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Dose-Response Relat | 2021 |
Multimodal Analgesic Regimen for Spine Surgery: A Randomized Placebo-controlled Trial.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Double-Blind Method; Drug Therapy | 2020 |
Multimodal Analgesic Regimen for Spine Surgery: A Randomized Placebo-controlled Trial.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Double-Blind Method; Drug Therapy | 2020 |
Multimodal Analgesic Regimen for Spine Surgery: A Randomized Placebo-controlled Trial.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Double-Blind Method; Drug Therapy | 2020 |
Multimodal Analgesic Regimen for Spine Surgery: A Randomized Placebo-controlled Trial.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Double-Blind Method; Drug Therapy | 2020 |
Effect of Ketamine Added to Ropivacaine in Nerve Block for Postoperative Pain Management in Patients Undergoing Anterior Cruciate Ligament Reconstruction: A Randomized Trial.
Topics: Adult; Analgesia; Analgesics; Anesthetics, Local; Anterior Cruciate Ligament Reconstruction; Double- | 2020 |
The efficacy of ketamine in total knee arthroplasty: a randomized controlled trial protocol.
Topics: Analgesics; Arthroplasty, Replacement, Knee; Double-Blind Method; Humans; Ketamine; Pain Management; | 2020 |
Use of Various Doses of S-Ketamine in Treatment of Depression and Pain in Cervical Carcinoma Patients with Mild/Moderate Depression After Laparoscopic Total Hysterectomy.
Topics: Adult; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Carcinoma; Depression; Depressive D | 2020 |
Intrathecal Morphine Versus Ketamine in Postoperative Pain After Hysterectomy: Double-Blinded, Randomized Clinical Trial.
Topics: Analgesia, Patient-Controlled; Analgesics, Opioid; Double-Blind Method; Female; Humans; Hysterectomy | 2020 |
Ketamine Enhances Intranasal Dexmedetomidine-Induced Sedation in Children: A Randomized, Double-Blind Trial.
Topics: Administration, Intranasal; Adrenergic alpha-Agonists; Child; Child, Preschool; Dexmedetomidine; Dos | 2020 |
Analgesic effects of low-dose ketamine after spinal fusion in adults: A protocol of prospective randomized trial.
Topics: Analgesics; Double-Blind Method; Humans; Ketamine; Pain Measurement; Pain, Postoperative; Prospectiv | 2020 |
Effects of intraarticular ketamine combined with periarticular bupivacaine on postoperative pain after arthroscopic meniscectomy.
Topics: Adolescent; Adult; Aged; Analgesics; Analgesics, Opioid; Anesthetics, Local; Arthroscopy; Bupivacain | 2020 |
Analgesic efficacy of ketamine and magnesium after laparoscopic sleeve gastrectomy: A randomized, double-blind, placebo-controlled trial.
Topics: Analgesics; Analgesics, Opioid; Double-Blind Method; Gastrectomy; Humans; Ketamine; Laparoscopy; Mag | 2021 |
Comparison of Dexmedetomidine and Ketamine for Managing Postoperative Symptoms After Third-Molar Surgery.
Topics: Dexmedetomidine; Edema; Female; Humans; Ketamine; Male; Molar; Molar, Third; Pain, Postoperative; Po | 2021 |
Ketamine infusion reduces narcotic requirements following gastric bypass surgery: a randomized controlled trial.
Topics: Analgesics; Analgesics, Opioid; Double-Blind Method; Gastric Bypass; Humans; Ketamine; Morphine; Nar | 2021 |
Perioperative Methadone and Ketamine for Postoperative Pain Control in Spinal Surgical Patients: A Randomized, Double-blind, Placebo-controlled Trial.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesics; Double-Blind Method; Drug Therapy, Combinati | 2021 |
Effects of perioperative saphenous and sciatic nerve blocks, lumbosacral epidural or morphine-lidocaine-ketamine infusion on postoperative pain and sedation in dogs undergoing tibial plateau leveling osteotomy.
Topics: Anesthesia, Conduction; Animals; Dog Diseases; Dogs; Ketamine; Lidocaine; Morphine; Osteotomy; Pain, | 2021 |
Effect of preoperative subanaesthetic ketamine on postoperative pain in women undergoing modified radical mastectomy: A randomised control trial.
Topics: Analgesics; Breast Neoplasms; Double-Blind Method; Female; Humans; Ketamine; Mastectomy; Mastectomy, | 2021 |
S-ketamine in patient-controlled analgesia reduces opioid consumption in a dose-dependent manner after major lumbar fusion surgery: A randomized, double-blind, placebo-controlled clinical trial.
Topics: Adult; Aged; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Dose-Response Relationsh | 2021 |
S-ketamine in patient-controlled analgesia reduces opioid consumption in a dose-dependent manner after major lumbar fusion surgery: A randomized, double-blind, placebo-controlled clinical trial.
Topics: Adult; Aged; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Dose-Response Relationsh | 2021 |
S-ketamine in patient-controlled analgesia reduces opioid consumption in a dose-dependent manner after major lumbar fusion surgery: A randomized, double-blind, placebo-controlled clinical trial.
Topics: Adult; Aged; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Dose-Response Relationsh | 2021 |
S-ketamine in patient-controlled analgesia reduces opioid consumption in a dose-dependent manner after major lumbar fusion surgery: A randomized, double-blind, placebo-controlled clinical trial.
Topics: Adult; Aged; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Dose-Response Relationsh | 2021 |
S-ketamine in patient-controlled analgesia reduces opioid consumption in a dose-dependent manner after major lumbar fusion surgery: A randomized, double-blind, placebo-controlled clinical trial.
Topics: Adult; Aged; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Dose-Response Relationsh | 2021 |
S-ketamine in patient-controlled analgesia reduces opioid consumption in a dose-dependent manner after major lumbar fusion surgery: A randomized, double-blind, placebo-controlled clinical trial.
Topics: Adult; Aged; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Dose-Response Relationsh | 2021 |
S-ketamine in patient-controlled analgesia reduces opioid consumption in a dose-dependent manner after major lumbar fusion surgery: A randomized, double-blind, placebo-controlled clinical trial.
Topics: Adult; Aged; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Dose-Response Relationsh | 2021 |
S-ketamine in patient-controlled analgesia reduces opioid consumption in a dose-dependent manner after major lumbar fusion surgery: A randomized, double-blind, placebo-controlled clinical trial.
Topics: Adult; Aged; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Dose-Response Relationsh | 2021 |
S-ketamine in patient-controlled analgesia reduces opioid consumption in a dose-dependent manner after major lumbar fusion surgery: A randomized, double-blind, placebo-controlled clinical trial.
Topics: Adult; Aged; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Dose-Response Relationsh | 2021 |
Analgesic effects of intravenous ketamine after spinal anaesthesia for non-elective caesarean delivery: a randomised controlled trial.
Topics: Administration, Intravenous; Analgesics, Opioid; Anesthesia, Spinal; Cesarean Section; Double-Blind | 2021 |
Low dose intraoperative ketamine infusion with multilevel paravertebral block for pain after video-assisted thoracic surgery: a randomized-controlled study.
Topics: Analgesia, Patient-Controlled; Analgesics, Opioid; Humans; Ketamine; Nerve Block; Pain, Postoperativ | 2021 |
Comparison of topical ropivacaine with and without ketamine on post-surgical pain in children undergoing tonsillectomy: a randomized controlled double-blind study.
Topics: Amides; Analgesics; Anesthesia, Local; Child; Child, Preschool; Double-Blind Method; Female; Humans; | 2017 |
Comparison of ketamine-propofol and ketamine-dexmedetomidine combinations in children for sedation during tooth extraction.
Topics: Anesthetics, Dissociative; Anxiety; Child; Child, Preschool; Deep Sedation; Dexmedetomidine; Female; | 2017 |
Effect of Intrathecally Administered Ketamine, Morphine, and Their Combination Added to Bupivacaine in Patients Undergoing Major Abdominal Cancer Surgery a Randomized, Double-Blind Study.
Topics: Abdominal Neoplasms; Adult; Analgesia; Analgesics; Bupivacaine; Digestive System Surgical Procedures | 2018 |
Intraoperative ketamine for prevention of postoperative delirium or pain after major surgery in older adults: an international, multicentre, double-blind, randomised clinical trial.
Topics: Aged; Analgesics; Central Nervous System Agents; Delirium; Double-Blind Method; Drug Administration | 2017 |
Intraoperative ketamine for prevention of postoperative delirium or pain after major surgery in older adults: an international, multicentre, double-blind, randomised clinical trial.
Topics: Aged; Analgesics; Central Nervous System Agents; Delirium; Double-Blind Method; Drug Administration | 2017 |
Intraoperative ketamine for prevention of postoperative delirium or pain after major surgery in older adults: an international, multicentre, double-blind, randomised clinical trial.
Topics: Aged; Analgesics; Central Nervous System Agents; Delirium; Double-Blind Method; Drug Administration | 2017 |
Intraoperative ketamine for prevention of postoperative delirium or pain after major surgery in older adults: an international, multicentre, double-blind, randomised clinical trial.
Topics: Aged; Analgesics; Central Nervous System Agents; Delirium; Double-Blind Method; Drug Administration | 2017 |
Intraoperative ketamine for prevention of postoperative delirium or pain after major surgery in older adults: an international, multicentre, double-blind, randomised clinical trial.
Topics: Aged; Analgesics; Central Nervous System Agents; Delirium; Double-Blind Method; Drug Administration | 2017 |
Intraoperative ketamine for prevention of postoperative delirium or pain after major surgery in older adults: an international, multicentre, double-blind, randomised clinical trial.
Topics: Aged; Analgesics; Central Nervous System Agents; Delirium; Double-Blind Method; Drug Administration | 2017 |
Intraoperative ketamine for prevention of postoperative delirium or pain after major surgery in older adults: an international, multicentre, double-blind, randomised clinical trial.
Topics: Aged; Analgesics; Central Nervous System Agents; Delirium; Double-Blind Method; Drug Administration | 2017 |
Intraoperative ketamine for prevention of postoperative delirium or pain after major surgery in older adults: an international, multicentre, double-blind, randomised clinical trial.
Topics: Aged; Analgesics; Central Nervous System Agents; Delirium; Double-Blind Method; Drug Administration | 2017 |
Intraoperative ketamine for prevention of postoperative delirium or pain after major surgery in older adults: an international, multicentre, double-blind, randomised clinical trial.
Topics: Aged; Analgesics; Central Nervous System Agents; Delirium; Double-Blind Method; Drug Administration | 2017 |
Intraoperative ketamine for prevention of postoperative delirium or pain after major surgery in older adults: an international, multicentre, double-blind, randomised clinical trial.
Topics: Aged; Analgesics; Central Nervous System Agents; Delirium; Double-Blind Method; Drug Administration | 2017 |
Intraoperative ketamine for prevention of postoperative delirium or pain after major surgery in older adults: an international, multicentre, double-blind, randomised clinical trial.
Topics: Aged; Analgesics; Central Nervous System Agents; Delirium; Double-Blind Method; Drug Administration | 2017 |
Intraoperative ketamine for prevention of postoperative delirium or pain after major surgery in older adults: an international, multicentre, double-blind, randomised clinical trial.
Topics: Aged; Analgesics; Central Nervous System Agents; Delirium; Double-Blind Method; Drug Administration | 2017 |
Intraoperative ketamine for prevention of postoperative delirium or pain after major surgery in older adults: an international, multicentre, double-blind, randomised clinical trial.
Topics: Aged; Analgesics; Central Nervous System Agents; Delirium; Double-Blind Method; Drug Administration | 2017 |
Intraoperative ketamine for prevention of postoperative delirium or pain after major surgery in older adults: an international, multicentre, double-blind, randomised clinical trial.
Topics: Aged; Analgesics; Central Nervous System Agents; Delirium; Double-Blind Method; Drug Administration | 2017 |
Intraoperative ketamine for prevention of postoperative delirium or pain after major surgery in older adults: an international, multicentre, double-blind, randomised clinical trial.
Topics: Aged; Analgesics; Central Nervous System Agents; Delirium; Double-Blind Method; Drug Administration | 2017 |
Intraoperative ketamine for prevention of postoperative delirium or pain after major surgery in older adults: an international, multicentre, double-blind, randomised clinical trial.
Topics: Aged; Analgesics; Central Nervous System Agents; Delirium; Double-Blind Method; Drug Administration | 2017 |
Intraoperative ketamine for prevention of postoperative delirium or pain after major surgery in older adults: an international, multicentre, double-blind, randomised clinical trial.
Topics: Aged; Analgesics; Central Nervous System Agents; Delirium; Double-Blind Method; Drug Administration | 2017 |
Intraoperative ketamine for prevention of postoperative delirium or pain after major surgery in older adults: an international, multicentre, double-blind, randomised clinical trial.
Topics: Aged; Analgesics; Central Nervous System Agents; Delirium; Double-Blind Method; Drug Administration | 2017 |
Intraoperative ketamine for prevention of postoperative delirium or pain after major surgery in older adults: an international, multicentre, double-blind, randomised clinical trial.
Topics: Aged; Analgesics; Central Nervous System Agents; Delirium; Double-Blind Method; Drug Administration | 2017 |
Intraoperative ketamine for prevention of postoperative delirium or pain after major surgery in older adults: an international, multicentre, double-blind, randomised clinical trial.
Topics: Aged; Analgesics; Central Nervous System Agents; Delirium; Double-Blind Method; Drug Administration | 2017 |
Intraoperative ketamine for prevention of postoperative delirium or pain after major surgery in older adults: an international, multicentre, double-blind, randomised clinical trial.
Topics: Aged; Analgesics; Central Nervous System Agents; Delirium; Double-Blind Method; Drug Administration | 2017 |
Intraoperative ketamine for prevention of postoperative delirium or pain after major surgery in older adults: an international, multicentre, double-blind, randomised clinical trial.
Topics: Aged; Analgesics; Central Nervous System Agents; Delirium; Double-Blind Method; Drug Administration | 2017 |
Intraoperative ketamine for prevention of postoperative delirium or pain after major surgery in older adults: an international, multicentre, double-blind, randomised clinical trial.
Topics: Aged; Analgesics; Central Nervous System Agents; Delirium; Double-Blind Method; Drug Administration | 2017 |
Intraoperative ketamine for prevention of postoperative delirium or pain after major surgery in older adults: an international, multicentre, double-blind, randomised clinical trial.
Topics: Aged; Analgesics; Central Nervous System Agents; Delirium; Double-Blind Method; Drug Administration | 2017 |
Intraoperative ketamine for prevention of postoperative delirium or pain after major surgery in older adults: an international, multicentre, double-blind, randomised clinical trial.
Topics: Aged; Analgesics; Central Nervous System Agents; Delirium; Double-Blind Method; Drug Administration | 2017 |
Intraoperative ketamine for prevention of postoperative delirium or pain after major surgery in older adults: an international, multicentre, double-blind, randomised clinical trial.
Topics: Aged; Analgesics; Central Nervous System Agents; Delirium; Double-Blind Method; Drug Administration | 2017 |
Intraoperative ketamine for prevention of postoperative delirium or pain after major surgery in older adults: an international, multicentre, double-blind, randomised clinical trial.
Topics: Aged; Analgesics; Central Nervous System Agents; Delirium; Double-Blind Method; Drug Administration | 2017 |
Intraoperative ketamine for prevention of postoperative delirium or pain after major surgery in older adults: an international, multicentre, double-blind, randomised clinical trial.
Topics: Aged; Analgesics; Central Nervous System Agents; Delirium; Double-Blind Method; Drug Administration | 2017 |
Intraoperative ketamine for prevention of postoperative delirium or pain after major surgery in older adults: an international, multicentre, double-blind, randomised clinical trial.
Topics: Aged; Analgesics; Central Nervous System Agents; Delirium; Double-Blind Method; Drug Administration | 2017 |
Intraoperative ketamine for prevention of postoperative delirium or pain after major surgery in older adults: an international, multicentre, double-blind, randomised clinical trial.
Topics: Aged; Analgesics; Central Nervous System Agents; Delirium; Double-Blind Method; Drug Administration | 2017 |
Intraoperative ketamine for prevention of postoperative delirium or pain after major surgery in older adults: an international, multicentre, double-blind, randomised clinical trial.
Topics: Aged; Analgesics; Central Nervous System Agents; Delirium; Double-Blind Method; Drug Administration | 2017 |
Intraoperative ketamine for prevention of postoperative delirium or pain after major surgery in older adults: an international, multicentre, double-blind, randomised clinical trial.
Topics: Aged; Analgesics; Central Nervous System Agents; Delirium; Double-Blind Method; Drug Administration | 2017 |
Intraoperative ketamine for prevention of postoperative delirium or pain after major surgery in older adults: an international, multicentre, double-blind, randomised clinical trial.
Topics: Aged; Analgesics; Central Nervous System Agents; Delirium; Double-Blind Method; Drug Administration | 2017 |
Intraoperative ketamine for prevention of postoperative delirium or pain after major surgery in older adults: an international, multicentre, double-blind, randomised clinical trial.
Topics: Aged; Analgesics; Central Nervous System Agents; Delirium; Double-Blind Method; Drug Administration | 2017 |
Intraoperative ketamine for prevention of postoperative delirium or pain after major surgery in older adults: an international, multicentre, double-blind, randomised clinical trial.
Topics: Aged; Analgesics; Central Nervous System Agents; Delirium; Double-Blind Method; Drug Administration | 2017 |
Intraoperative ketamine for prevention of postoperative delirium or pain after major surgery in older adults: an international, multicentre, double-blind, randomised clinical trial.
Topics: Aged; Analgesics; Central Nervous System Agents; Delirium; Double-Blind Method; Drug Administration | 2017 |
Efficacy of Postoperative Analgesia of Local Ketamine Wound Instillation Following Total Thyroidectomy: A Randomized, Double-blind, Controlled Clinical Trial.
Topics: Adolescent; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Egypt; Female; | 2018 |
A comparative study of ketamine gargle and lidocaine jelly application for the prevention of postoperative throat pain following general anaesthesia with endotracheal intubation.
Topics: Adolescent; Adult; Anesthesia, General; Double-Blind Method; Elective Surgical Procedures; Female; G | 2017 |
The effect of a perioperative ketamine infusion on the incidence of chronic postsurgical pain-a pilot study.
Topics: Adult; Aged; Chronic Pain; Female; Humans; Incidence; Ketamine; Male; Middle Aged; Pain, Postoperati | 2017 |
Effect of low-dose ketamine on post-operative serum IL-6 production among elective surgical patients: a randomized clinical trial.
Topics: Adolescent; Adult; Aged; Analgesics; Double-Blind Method; Female; Humans; Interleukin-1beta; Interle | 2017 |
Effect of low-dose ketamine on post-operative serum IL-6 production among elective surgical patients: a randomized clinical trial.
Topics: Adolescent; Adult; Aged; Analgesics; Double-Blind Method; Female; Humans; Interleukin-1beta; Interle | 2017 |
Effect of low-dose ketamine on post-operative serum IL-6 production among elective surgical patients: a randomized clinical trial.
Topics: Adolescent; Adult; Aged; Analgesics; Double-Blind Method; Female; Humans; Interleukin-1beta; Interle | 2017 |
Effect of low-dose ketamine on post-operative serum IL-6 production among elective surgical patients: a randomized clinical trial.
Topics: Adolescent; Adult; Aged; Analgesics; Double-Blind Method; Female; Humans; Interleukin-1beta; Interle | 2017 |
Efficacy of ketamine for postoperative pain following robotic thyroidectomy: A prospective randomised study.
Topics: Adult; Aged; Analgesics; Anesthesia, General; Female; Humans; Hypesthesia; Ketamine; Male; Middle Ag | 2018 |
Subcutaneous ketamine for postoperative pain relief in Rwanda: a randomized clinical trial.
Topics: Adult; Analgesics; Developing Countries; Double-Blind Method; Female; Humans; Injections, Subcutaneo | 2018 |
Dexmedetomidine-methadone-ketamine versus dexmedetomidine-methadone-alfaxalone for cats undergoing ovariectomy.
Topics: Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Combined; Animals; Cats; Dexmedetomidi | 2017 |
Effect of non-steroidal anti-inflammatory drugs on postoperative respiratory and heart rate in cats subjected to ovariohysterectomy.
Topics: Anesthesia; Animals; Anti-Inflammatory Agents, Non-Steroidal; Butorphanol; Cats; Female; Heart Rate; | 2018 |
Demonstration of analgesic effect of intranasal ketamine and intranasal fentanyl for postoperative pain after pediatric tonsillectomy.
Topics: Acetaminophen; Administration, Intranasal; Administration, Intravenous; Adolescent; Analgesics; Chil | 2018 |
Effect of local wound infiltration with ketamine versus dexmedetomidine on postoperative pain and stress after abdominal hysterectomy, a randomized trial.
Topics: Adult; Analgesia; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthetics, Local; Bupivacaine; Dex | 2018 |
Local mepivacaine before castration of horses under medetomidine isoflurane balanced anaesthesia is effective to reduce perioperative nociception and cytokine release.
Topics: Analgesics; Anesthesia; Anesthetics, Local; Animals; Arterial Pressure; Cardiotonic Agents; Clonixin | 2018 |
Preemptive Analgesia Decreases Pain Following Anorectal Surgery: A Prospective, Randomized, Double-Blinded, Placebo-Controlled Trial.
Topics: Acetaminophen; Adult; Ambulatory Surgical Procedures; Amines; Anal Canal; Analgesics; Analgesics, Op | 2018 |
Effects of a single subanaesthetic dose of ketamine on pain and mood after laparoscopic bariatric surgery: A randomised double-blind placebo controlled study.
Topics: Adult; Affect; Analgesics; Bariatric Surgery; Double-Blind Method; Female; Humans; Ketamine; Laparos | 2019 |
Effects of a single subanaesthetic dose of ketamine on pain and mood after laparoscopic bariatric surgery: A randomised double-blind placebo controlled study.
Topics: Adult; Affect; Analgesics; Bariatric Surgery; Double-Blind Method; Female; Humans; Ketamine; Laparos | 2019 |
Effects of a single subanaesthetic dose of ketamine on pain and mood after laparoscopic bariatric surgery: A randomised double-blind placebo controlled study.
Topics: Adult; Affect; Analgesics; Bariatric Surgery; Double-Blind Method; Female; Humans; Ketamine; Laparos | 2019 |
Effects of a single subanaesthetic dose of ketamine on pain and mood after laparoscopic bariatric surgery: A randomised double-blind placebo controlled study.
Topics: Adult; Affect; Analgesics; Bariatric Surgery; Double-Blind Method; Female; Humans; Ketamine; Laparos | 2019 |
Effects of a single subanaesthetic dose of ketamine on pain and mood after laparoscopic bariatric surgery: A randomised double-blind placebo controlled study.
Topics: Adult; Affect; Analgesics; Bariatric Surgery; Double-Blind Method; Female; Humans; Ketamine; Laparos | 2019 |
Effects of a single subanaesthetic dose of ketamine on pain and mood after laparoscopic bariatric surgery: A randomised double-blind placebo controlled study.
Topics: Adult; Affect; Analgesics; Bariatric Surgery; Double-Blind Method; Female; Humans; Ketamine; Laparos | 2019 |
Effects of a single subanaesthetic dose of ketamine on pain and mood after laparoscopic bariatric surgery: A randomised double-blind placebo controlled study.
Topics: Adult; Affect; Analgesics; Bariatric Surgery; Double-Blind Method; Female; Humans; Ketamine; Laparos | 2019 |
Effects of a single subanaesthetic dose of ketamine on pain and mood after laparoscopic bariatric surgery: A randomised double-blind placebo controlled study.
Topics: Adult; Affect; Analgesics; Bariatric Surgery; Double-Blind Method; Female; Humans; Ketamine; Laparos | 2019 |
Effects of a single subanaesthetic dose of ketamine on pain and mood after laparoscopic bariatric surgery: A randomised double-blind placebo controlled study.
Topics: Adult; Affect; Analgesics; Bariatric Surgery; Double-Blind Method; Female; Humans; Ketamine; Laparos | 2019 |
Low-dose ketamine infusion reduces postoperative hydromorphone requirements in opioid-tolerant patients following spinal fusion: A randomised controlled trial.
Topics: Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, Dissociative; Double-Blind Method; D | 2019 |
Low-dose ketamine infusion reduces postoperative hydromorphone requirements in opioid-tolerant patients following spinal fusion: A randomised controlled trial.
Topics: Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, Dissociative; Double-Blind Method; D | 2019 |
Low-dose ketamine infusion reduces postoperative hydromorphone requirements in opioid-tolerant patients following spinal fusion: A randomised controlled trial.
Topics: Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, Dissociative; Double-Blind Method; D | 2019 |
Low-dose ketamine infusion reduces postoperative hydromorphone requirements in opioid-tolerant patients following spinal fusion: A randomised controlled trial.
Topics: Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, Dissociative; Double-Blind Method; D | 2019 |
Intraoperative S-ketamine for the reduction of opioid consumption and pain one year after spine surgery: A randomized clinical trial of opioid-dependent patients.
Topics: Adult; Analgesics; Analgesics, Opioid; Double-Blind Method; Drug Administration Schedule; Female; Hu | 2019 |
Intraoperative S-ketamine for the reduction of opioid consumption and pain one year after spine surgery: A randomized clinical trial of opioid-dependent patients.
Topics: Adult; Analgesics; Analgesics, Opioid; Double-Blind Method; Drug Administration Schedule; Female; Hu | 2019 |
Intraoperative S-ketamine for the reduction of opioid consumption and pain one year after spine surgery: A randomized clinical trial of opioid-dependent patients.
Topics: Adult; Analgesics; Analgesics, Opioid; Double-Blind Method; Drug Administration Schedule; Female; Hu | 2019 |
Intraoperative S-ketamine for the reduction of opioid consumption and pain one year after spine surgery: A randomized clinical trial of opioid-dependent patients.
Topics: Adult; Analgesics; Analgesics, Opioid; Double-Blind Method; Drug Administration Schedule; Female; Hu | 2019 |
Intraoperative S-ketamine for the reduction of opioid consumption and pain one year after spine surgery: A randomized clinical trial of opioid-dependent patients.
Topics: Adult; Analgesics; Analgesics, Opioid; Double-Blind Method; Drug Administration Schedule; Female; Hu | 2019 |
Intraoperative S-ketamine for the reduction of opioid consumption and pain one year after spine surgery: A randomized clinical trial of opioid-dependent patients.
Topics: Adult; Analgesics; Analgesics, Opioid; Double-Blind Method; Drug Administration Schedule; Female; Hu | 2019 |
Intraoperative S-ketamine for the reduction of opioid consumption and pain one year after spine surgery: A randomized clinical trial of opioid-dependent patients.
Topics: Adult; Analgesics; Analgesics, Opioid; Double-Blind Method; Drug Administration Schedule; Female; Hu | 2019 |
Intraoperative S-ketamine for the reduction of opioid consumption and pain one year after spine surgery: A randomized clinical trial of opioid-dependent patients.
Topics: Adult; Analgesics; Analgesics, Opioid; Double-Blind Method; Drug Administration Schedule; Female; Hu | 2019 |
Intraoperative S-ketamine for the reduction of opioid consumption and pain one year after spine surgery: A randomized clinical trial of opioid-dependent patients.
Topics: Adult; Analgesics; Analgesics, Opioid; Double-Blind Method; Drug Administration Schedule; Female; Hu | 2019 |
Intraoperative S-ketamine for the reduction of opioid consumption and pain one year after spine surgery: A randomized clinical trial of opioid-dependent patients.
Topics: Adult; Analgesics; Analgesics, Opioid; Double-Blind Method; Drug Administration Schedule; Female; Hu | 2019 |
Intraoperative S-ketamine for the reduction of opioid consumption and pain one year after spine surgery: A randomized clinical trial of opioid-dependent patients.
Topics: Adult; Analgesics; Analgesics, Opioid; Double-Blind Method; Drug Administration Schedule; Female; Hu | 2019 |
Intraoperative S-ketamine for the reduction of opioid consumption and pain one year after spine surgery: A randomized clinical trial of opioid-dependent patients.
Topics: Adult; Analgesics; Analgesics, Opioid; Double-Blind Method; Drug Administration Schedule; Female; Hu | 2019 |
Intraoperative S-ketamine for the reduction of opioid consumption and pain one year after spine surgery: A randomized clinical trial of opioid-dependent patients.
Topics: Adult; Analgesics; Analgesics, Opioid; Double-Blind Method; Drug Administration Schedule; Female; Hu | 2019 |
Intraoperative S-ketamine for the reduction of opioid consumption and pain one year after spine surgery: A randomized clinical trial of opioid-dependent patients.
Topics: Adult; Analgesics; Analgesics, Opioid; Double-Blind Method; Drug Administration Schedule; Female; Hu | 2019 |
Intraoperative S-ketamine for the reduction of opioid consumption and pain one year after spine surgery: A randomized clinical trial of opioid-dependent patients.
Topics: Adult; Analgesics; Analgesics, Opioid; Double-Blind Method; Drug Administration Schedule; Female; Hu | 2019 |
Intraoperative S-ketamine for the reduction of opioid consumption and pain one year after spine surgery: A randomized clinical trial of opioid-dependent patients.
Topics: Adult; Analgesics; Analgesics, Opioid; Double-Blind Method; Drug Administration Schedule; Female; Hu | 2019 |
A randomized-controlled, double-blind study to evaluate the efficacy of caudal midazolam, ketamine and neostigmine as adjuvants to bupivacaine on postoperative analgesic in children undergoing lower abdominal surgery.
Topics: Abdomen; Analgesics; Anesthesia, Caudal; Anesthetics; Bupivacaine; Child, Preschool; Double-Blind Me | 2019 |
Ketamine infusion for 96 hr after thoracotomy: Effects on acute and persistent pain.
Topics: Adult; Aged; Aged, 80 and over; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Anest | 2019 |
Dexamethasone Versus Ketamine in the Interscalene Block in Patients Undergoing Arthroscopic Shoulder Surgery: A Randomized Double-Blinded Study.
Topics: Adult; Arthroscopy; Brachial Plexus Block; Dexamethasone; Double-Blind Method; Female; Humans; Ketam | 2018 |
Comparison of analgesia provided by lidocaine or morphine delivered epidurally in rabbits undergoing hindlimb orthopedic surgery.
Topics: Analgesics, Opioid; Anesthesia; Anesthetics, Local; Animals; Blood Pressure; Hindlimb; Injections, E | 2019 |
Intraoperative Ketamine in Total Knee Arthroplasty Does Not Decrease Pain and Narcotic Consumption: A Prospective Randomized Controlled Trial.
Topics: Aged; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthesia, Spinal; Arthroplasty, Replaceme | 2019 |
Comparison of Topical and Subcutaneous Bupivacaine Infiltration with Subcutaneous Ketamine on Postoperative Pain in Total Abdominal Hysterectomy.
Topics: Administration, Topical; Adult; Analgesics; Bupivacaine; Double-Blind Method; Drug Therapy, Combinat | 2019 |
Prolonged Perioperative Use of Pregabalin and Ketamine to Prevent Persistent Pain after Cardiac Surgery.
Topics: Aged; Analgesics; Cardiac Surgical Procedures; Chronic Pain; Double-Blind Method; Female; Follow-Up | 2019 |
Bilateral subcostal transversus abdominis plane block does not improve the postoperative analgesia provided by multimodal analgesia after laparoscopic cholecystectomy: A randomised placebo-controlled trial.
Topics: Abdominal Muscles; Acetaminophen; Adult; Aged; Analgesia; Analgesics, Opioid; Anesthetics; Cholecyst | 2019 |
Does Sub-Anesthetic Ketamine Provide Postoperative Analgesia for Third Molar Surgery?
Topics: Analgesics, Opioid; Anesthesia, Dental; Anesthetics; Double-Blind Method; Humans; Ketamine; Molar, T | 2019 |
Fentanyl-based intravenous patient-controlled analgesia with low dose of ketamine is not inferior to thoracic epidural analgesia for acute post-thoracotomy pain following video-assisted thoracic surgery: A randomized controlled study.
Topics: Administration, Intravenous; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics; Drug Th | 2019 |
A randomized study of surgical site infiltration with bupivacaine or ketamine for pain relief in children following cleft palate repair.
Topics: Anesthesia, Local; Anesthetics, Dissociative; Anesthetics, Local; Bupivacaine; Child; Child Behavior | 2013 |
Comparison of topical tramadol and ketamine in pain treatment after tonsillectomy.
Topics: Administration, Topical; Analgesics; Analgesics, Opioid; Child; Child, Preschool; Data Interpretatio | 2013 |
Brief report: perioperative analgesic efficacy and plasma concentrations of S+ -ketamine in continuous epidural infusion during thoracic surgery.
Topics: Adult; Aged; Aged, 80 and over; Analgesia, Epidural; Analgesics; Female; Humans; Ketamine; Male; Mid | 2013 |
Effects of intra-operative ketamine administration on postoperative catheter-related bladder discomfort: a double-blind clinical trial.
Topics: Adult; Analgesics; Double-Blind Method; Female; Humans; Incidence; Intraoperative Care; Ketamine; Ma | 2014 |
Addition of ketamine to propofol-alfentanil anesthesia may reduce postoperative pain in laparoscopic cholecystectomy.
Topics: Adult; Alfentanil; Anesthesia, Intravenous; Anesthetics, Intravenous; Cholecystectomy, Laparoscopic; | 2013 |
Combination of oral clonidine and intravenous low-dose ketamine reduces the consumption of postoperative patient-controlled analgesia morphine after spine surgery.
Topics: Administration, Oral; Adult; Aged; Analgesia, Patient-Controlled; Clonidine; Drug Therapy, Combinati | 2013 |
[A comparison of the effects of intraoperative tramadol and ketamine usage for postoperative pain relief in patients undergoing tonsillectomy].
Topics: Adolescent; Analgesics; Analgesics, Opioid; Child; Child, Preschool; Drug Administration Schedule; F | 2013 |
Effect of ketamine as an adjunct to intravenous patient-controlled analgesia, in patients at high risk of postoperative nausea and vomiting undergoing lumbar spinal surgery.
Topics: Adult; Aged; Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; Analgesics, Opioid; Drug Admin | 2013 |
Ketamine decreases postoperative pain scores in patients taking opioids for chronic pain: results of a prospective, randomized, double-blind study.
Topics: Analgesics, Opioid; Anesthetics, Dissociative; Chronic Pain; Double-Blind Method; Drug Therapy, Comb | 2013 |
Efficacy of pre-incisional peritonsillar infiltration of ketamine for post-tonsillectomy analgesia in children.
Topics: Analgesia; Anesthetics, Dissociative; Anesthetics, Local; Child; Child, Preschool; Dose-Response Rel | 2013 |
The comparison of preincisional peritonsillar infiltration of ketamine and tramadol for postoperative pain relief on children following adenotonsillectomy.
Topics: Adenoidectomy; Analgesics; Analgesics, Opioid; Anesthesia, Local; Child; Child, Preschool; Double-Bl | 2013 |
Pain and recovery after total knee arthroplasty: a 12-month follow-up after a prospective randomized study evaluating Nefopam and Ketamine for early rehabilitation.
Topics: Aged; Analgesics; Arthroplasty, Replacement, Knee; Chronic Pain; Female; Follow-Up Studies; Humans; | 2014 |
Ketamine improves postoperative pain and emergence agitation following adenotonsillectomy in children. A randomized clinical trial.
Topics: Adenoidectomy; Adolescent; Akathisia, Drug-Induced; Analgesics; Anesthesia Recovery Period; Child; C | 2013 |
Perioperative epidural or intravenous ketamine does not improve the effectiveness of thoracic epidural analgesia for acute and chronic pain after thoracotomy.
Topics: Acute Disease; Administration, Intravenous; Adult; Analgesia, Epidural; Analgesics; Chronic Pain; Co | 2014 |
The analgesic efficiency of combined pregabalin and ketamine for total hip arthroplasty: a randomised, double-blind, controlled study.
Topics: Administration, Oral; Adult; Aged; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ar | 2014 |
Effect of perioperative electroacupuncture as an adjunctive therapy on postoperative analgesia with tramadol and ketamine in prostatectomy: a randomised sham-controlled single-blind trial.
Topics: Acupuncture Analgesia; Aged; Analgesics; Analgesics, Opioid; Combined Modality Therapy; Electroacupu | 2014 |
Evaluation of the analgesic effect of ketamine as an additive to intrathecal bupivacaine in patients undergoing cesarean section.
Topics: Adult; Analgesics; Anesthetics, Local; Bupivacaine; Cesarean Section; Double-Blind Method; Female; H | 2013 |
Comparison between the combination of gabapentin, ketamine, lornoxicam, and local ropivacaine and each of these drugs alone for pain after laparoscopic cholecystectomy: a randomized trial.
Topics: Adult; Amides; Amines; Cholecystectomy, Laparoscopic; Cyclohexanecarboxylic Acids; Double-Blind Meth | 2015 |
Ketamine and magnesium association reduces morphine consumption after scoliosis surgery: prospective randomised double-blind study.
Topics: Adolescent; Analgesia, Patient-Controlled; Analgesics; Child; Double-Blind Method; Drug Therapy, Com | 2014 |
Ketamine and magnesium association reduces morphine consumption after scoliosis surgery: prospective randomised double-blind study.
Topics: Adolescent; Analgesia, Patient-Controlled; Analgesics; Child; Double-Blind Method; Drug Therapy, Com | 2014 |
Ketamine and magnesium association reduces morphine consumption after scoliosis surgery: prospective randomised double-blind study.
Topics: Adolescent; Analgesia, Patient-Controlled; Analgesics; Child; Double-Blind Method; Drug Therapy, Com | 2014 |
Ketamine and magnesium association reduces morphine consumption after scoliosis surgery: prospective randomised double-blind study.
Topics: Adolescent; Analgesia, Patient-Controlled; Analgesics; Child; Double-Blind Method; Drug Therapy, Com | 2014 |
Efficacy of intraarticular application of ketamine or ketamine-levobupivacaine combination on post-operative pain after arthroscopic meniscectomy.
Topics: Adolescent; Adult; Aged; Arthroscopy; Bupivacaine; Double-Blind Method; Drug Therapy, Combination; F | 2015 |
Postoperative comparison of four perioperative analgesia protocols in dogs undergoing stifle joint surgery.
Topics: Amides; Analgesia; Analgesics; Anesthetics, Local; Animals; Dog Diseases; Dogs; Female; Ketamine; Li | 2014 |
Chronic postthoracotomy pain and perioperative ketamine infusion.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics; Chronic Pain; Double-Blind Method; Female; Follow- | 2014 |
Prolonged perioperative infusion of low-dose ketamine does not alter opioid use after pediatric scoliosis surgery.
Topics: Adolescent; Analgesics, Opioid; Anesthetics, Dissociative; Child; Double-Blind Method; Drug Toleranc | 2014 |
Intraoperative low-dose ketamine infusion reduces acute postoperative pain following total knee replacement surgery: a prospective, randomized double-blind placebo-controlled trial.
Topics: Adult; Aged; Analgesia, Patient-Controlled; Analgesics; Anesthesia, General; Arthroplasty, Replaceme | 2014 |
Postoperative analgesic effects of either a constant rate infusion of fentanyl, lidocaine, ketamine, dexmedetomidine, or the combination lidocaine-ketamine-dexmedetomidine after ovariohysterectomy in dogs.
Topics: Analgesia; Analgesics, Non-Narcotic; Anesthetics, Dissociative; Anesthetics, Inhalation; Anesthetics | 2015 |
Does intravenous ketamine enhance analgesia after arthroscopic shoulder surgery with ultrasound guided single-injection interscalene block?: a randomized, prospective, double-blind trial.
Topics: Adult; Aged; Analgesia, Patient-Controlled; Analgesics; Arthroscopy; Brachial Plexus; Double-Blind M | 2014 |
A comparative evaluation of intranasal dexmedetomidine, midazolam and ketamine for their sedative and analgesic properties: a triple blind randomized study.
Topics: Administration, Intranasal; Adolescent; Analgesics; Anesthesia Recovery Period; Anesthesia, Dental; | 2014 |
A comparative evaluation of intranasal dexmedetomidine, midazolam and ketamine for their sedative and analgesic properties: a triple blind randomized study.
Topics: Administration, Intranasal; Adolescent; Analgesics; Anesthesia Recovery Period; Anesthesia, Dental; | 2014 |
A comparative evaluation of intranasal dexmedetomidine, midazolam and ketamine for their sedative and analgesic properties: a triple blind randomized study.
Topics: Administration, Intranasal; Adolescent; Analgesics; Anesthesia Recovery Period; Anesthesia, Dental; | 2014 |
A comparative evaluation of intranasal dexmedetomidine, midazolam and ketamine for their sedative and analgesic properties: a triple blind randomized study.
Topics: Administration, Intranasal; Adolescent; Analgesics; Anesthesia Recovery Period; Anesthesia, Dental; | 2014 |
The effect of local injections of bupivacaine plus ketamine, bupivacaine alone, and placebo on reducing postoperative anal fistula pain: a randomized clinical trial.
Topics: Adult; Anesthetics, Dissociative; Anesthetics, Local; Bupivacaine; Double-Blind Method; Female; Huma | 2014 |
Clinical pharmacy intervention post tonsillectomy: a randomized control trial.
Topics: Analgesics, Opioid; Child; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Ketamine; | 2015 |
Comparison of different administration of ketamine and intravenous tramadol hydrochloride for postoperative pain relief and sedation after pediatric tonsillectomy.
Topics: Adenoidectomy; Administration, Intravenous; Administration, Rectal; Analgesics; Child; Child, Presch | 2015 |
The effect of KETODEX on the incidence and severity of emergence agitation in children undergoing adenotonsillectomy using sevoflurane based-anesthesia.
Topics: Adenoidectomy; Adrenergic alpha-2 Receptor Agonists; Airway Extubation; Anesthesia Recovery Period; | 2015 |
The effect of KETODEX on the incidence and severity of emergence agitation in children undergoing adenotonsillectomy using sevoflurane based-anesthesia.
Topics: Adenoidectomy; Adrenergic alpha-2 Receptor Agonists; Airway Extubation; Anesthesia Recovery Period; | 2015 |
The effect of KETODEX on the incidence and severity of emergence agitation in children undergoing adenotonsillectomy using sevoflurane based-anesthesia.
Topics: Adenoidectomy; Adrenergic alpha-2 Receptor Agonists; Airway Extubation; Anesthesia Recovery Period; | 2015 |
The effect of KETODEX on the incidence and severity of emergence agitation in children undergoing adenotonsillectomy using sevoflurane based-anesthesia.
Topics: Adenoidectomy; Adrenergic alpha-2 Receptor Agonists; Airway Extubation; Anesthesia Recovery Period; | 2015 |
A comparative evaluation of nebulized dexmedetomidine, nebulized ketamine, and their combination as premedication for outpatient pediatric dental surgery.
Topics: Administration, Inhalation; Age Factors; Ambulatory Care; Anesthesia, General; Child; Child, Prescho | 2015 |
A comparative evaluation of nebulized dexmedetomidine, nebulized ketamine, and their combination as premedication for outpatient pediatric dental surgery.
Topics: Administration, Inhalation; Age Factors; Ambulatory Care; Anesthesia, General; Child; Child, Prescho | 2015 |
A comparative evaluation of nebulized dexmedetomidine, nebulized ketamine, and their combination as premedication for outpatient pediatric dental surgery.
Topics: Administration, Inhalation; Age Factors; Ambulatory Care; Anesthesia, General; Child; Child, Prescho | 2015 |
A comparative evaluation of nebulized dexmedetomidine, nebulized ketamine, and their combination as premedication for outpatient pediatric dental surgery.
Topics: Administration, Inhalation; Age Factors; Ambulatory Care; Anesthesia, General; Child; Child, Prescho | 2015 |
A comparative evaluation of nebulized dexmedetomidine, nebulized ketamine, and their combination as premedication for outpatient pediatric dental surgery.
Topics: Administration, Inhalation; Age Factors; Ambulatory Care; Anesthesia, General; Child; Child, Prescho | 2015 |
A comparative evaluation of nebulized dexmedetomidine, nebulized ketamine, and their combination as premedication for outpatient pediatric dental surgery.
Topics: Administration, Inhalation; Age Factors; Ambulatory Care; Anesthesia, General; Child; Child, Prescho | 2015 |
A comparative evaluation of nebulized dexmedetomidine, nebulized ketamine, and their combination as premedication for outpatient pediatric dental surgery.
Topics: Administration, Inhalation; Age Factors; Ambulatory Care; Anesthesia, General; Child; Child, Prescho | 2015 |
A comparative evaluation of nebulized dexmedetomidine, nebulized ketamine, and their combination as premedication for outpatient pediatric dental surgery.
Topics: Administration, Inhalation; Age Factors; Ambulatory Care; Anesthesia, General; Child; Child, Prescho | 2015 |
A comparative evaluation of nebulized dexmedetomidine, nebulized ketamine, and their combination as premedication for outpatient pediatric dental surgery.
Topics: Administration, Inhalation; Age Factors; Ambulatory Care; Anesthesia, General; Child; Child, Prescho | 2015 |
Perioperative low-dose ketamine improves postoperative analgesia following Cesarean delivery with general anesthesia.
Topics: Adult; Analgesics; Anesthesia, General; Cesarean Section; Double-Blind Method; Female; Humans; Ketam | 2016 |
Evaluation of the effect of ketamine on remifentanil-induced hyperalgesia: a double-blind, randomized study.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Cholecystectomy, Laparoscopic; | 2015 |
Preoperative and postoperative analgesic techniques in the treatment of patients undergoing transabdominal hysterectomy: a preliminary randomized trial.
Topics: Adult; Analgesia, Epidural; Analgesics; Analgesics, Opioid; Double-Blind Method; Drug Therapy, Combi | 2015 |
Comparison of Small Dose Ketamine and Dexmedetomidine Infusion for Postoperative Analgesia in Spine Surgery--A Prospective Randomized Double-blind Placebo Controlled Study.
Topics: Adolescent; Adult; Analgesics; Analgesics, Non-Narcotic; Dexmedetomidine; Double-Blind Method; Femal | 2016 |
Comparison of the Effects of Topical Ketamine and Tramadol on Postoperative Pain After Mandibular Molar Extraction.
Topics: Administration, Topical; Adult; Female; Humans; Ketamine; Male; Mandible; Pain, Postoperative; Tooth | 2015 |
Effects of Dexmedetomidine and Ketamine-Dexmedetomidine with and without Buprenorphine on Corticoadrenal Function in Rabbits.
Topics: Anesthetics; Animals; Buprenorphine; Dexmedetomidine; Drug Therapy, Combination; Female; Hydrocortis | 2015 |
Is pre-emptive administration of ketamine a significant adjunction to intravenous morphine analgesia for controlling postoperative pain? A randomized, double-blind, placebo-controlled clinical trial.
Topics: Analgesics; Analgesics, Opioid; Dose-Response Relationship, Drug; Double-Blind Method; Female; Human | 2015 |
Intra- and postoperative low-dose ketamine for adolescent idiopathic scoliosis surgery: a randomized controlled trial.
Topics: Adolescent; Child; Female; Humans; Ketamine; Male; Morphine; Pain, Postoperative; Postoperative Naus | 2015 |
COMPARISON OF THE EFFECTS OF ORAL VS. PERITONSILLAR INFILTRATION OF KETAMINE IN PAIN REDUCTION AFTER TONSILLECTOMY: A RANDOMIZED CLINICAL TRIAL.
Topics: Administration, Oral; Child; Child, Preschool; Double-Blind Method; Female; Humans; Ketamine; Male; | 2015 |
Effect of preemptive intra-articular morphine and ketamine on pain after arthroscopic rotator cuff repair: a prospective, double-blind, randomized controlled study.
Topics: Analgesia, Patient-Controlled; Analgesics; Arthroscopy; Double-Blind Method; Drug Therapy, Combinati | 2016 |
Effect of intraoperative application of ketamine on postoperative depressed mood in patients undergoing elective orthopedic surgery.
Topics: Adult; Brain-Derived Neurotrophic Factor; Double-Blind Method; Elective Surgical Procedures; Female; | 2016 |
Comparison of efficacy of prophylactic ketamine and dexmedetomidine on postoperative bladder catheter-related discomfort.
Topics: Administration, Intravenous; Adolescent; Adult; Aged; Analgesics; Analgesics, Non-Narcotic; Cystosco | 2016 |
Comparison of the effects of magnesium and ketamine on postoperative pain and morphine consumption. A double-blind randomized controlled clinical study.
Topics: Aged; Analgesics; Analgesics, Opioid; Chemotherapy, Adjuvant; Double-Blind Method; Female; Humans; H | 2016 |
Comparison of the effects of magnesium and ketamine on postoperative pain and morphine consumption. A double-blind randomized controlled clinical study.
Topics: Aged; Analgesics; Analgesics, Opioid; Chemotherapy, Adjuvant; Double-Blind Method; Female; Humans; H | 2016 |
Comparison of the effects of magnesium and ketamine on postoperative pain and morphine consumption. A double-blind randomized controlled clinical study.
Topics: Aged; Analgesics; Analgesics, Opioid; Chemotherapy, Adjuvant; Double-Blind Method; Female; Humans; H | 2016 |
Comparison of the effects of magnesium and ketamine on postoperative pain and morphine consumption. A double-blind randomized controlled clinical study.
Topics: Aged; Analgesics; Analgesics, Opioid; Chemotherapy, Adjuvant; Double-Blind Method; Female; Humans; H | 2016 |
CLINICAL RESEARCH REGARDING PREEMPTIVE ANALGESIC EFFECT OF PREOPERATIVE KETAMINE AFTER TRANSURETHRAL RESECTION OF PROSTATE.
Topics: Administration, Intravenous; Aged; Analgesics; Double-Blind Method; Humans; Ketamine; Laryngeal Mask | 2015 |
Comparison of effects of intravenous midazolam and ketamine on emergence agitation in children: Randomized controlled trial.
Topics: Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Dissociative; Anesthetics, Inhalation; | 2016 |
Effect of a single dose of lidocaine and ketamine on intraoperative opioids requirements in patients undergoing elective gynecological laparotomies under general anesthesia. A randomized, placebo controlled pilot study.
Topics: Adolescent; Adult; Analgesics, Opioid; Anesthesia, General; Anesthetics, Dissociative; Anesthetics, | 2016 |
A Comparative Study between the Effect of Combined Local Anesthetic and Low-dose Ketamine with Local Anesthetic on Postoperative Complications after Impacted Third Molar Surgery.
Topics: Adolescent; Adult; Anesthetics, Dissociative; Anesthetics, Local; Drug Therapy, Combination; Edema; | 2015 |
Low-Dose Ketamine Infusions for Highly Opioid-Tolerant Adults Following Spinal Surgery: A Retrospective Before-and-after Study.
Topics: Adult; Aged; Aged, 80 and over; Analgesics; Analgesics, Opioid; Drug Administration Schedule; Female | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Topics: Abdomen; Analgesics; Analgesics, Opioid; Delirium; Double-Blind Method; Elective Surgical Procedures | 2016 |
COMPARISON OF POSTOPERATIVE ANALGESIC EFFECT OF INTRATHECAL KETAMINE AND FENTANYL ADDED TO BUPIVACAINE IN PATIENTS UNDERGOING CESAREAN SECTION: A PROSPECTIVE RANDOMIZED DOUBLE-BLIND STUDY.
Topics: Adolescent; Adult; Analgesia, Obstetrical; Bupivacaine; Cesarean Section; Double-Blind Method; Femal | 2016 |
Prolonged Perioperative Low-Dose Ketamine Does Not Improve Short and Long-term Outcomes After Pediatric Idiopathic Scoliosis Surgery.
Topics: Analgesia, Patient-Controlled; Child; Double-Blind Method; Female; Humans; Ketamine; Male; Morphine; | 2017 |
Comparison of intramuscular alfaxalone and ketamine combined with dexmedetomidine and butorphanol for castration in cats.
Topics: Anesthesia; Anesthetics, Combined; Animals; Blood Pressure; Butorphanol; Cats; Dexmedetomidine; Hear | 2017 |
Intrathecal Dexmedetomidine, Ketamine, and their Combination Added to Bupivacaine for Postoperative Analgesia in Major Abdominal Cancer Surgery.
Topics: Abdominal Neoplasms; Adult; Analgesia; Anesthetics, Local; Bupivacaine; Dexmedetomidine; Double-Blin | 2016 |
Clonidine and ketamine for stable hemodynamics in off-pump coronary artery bypass.
Topics: Adrenergic alpha-2 Receptor Agonists; Aged; Airway Extubation; Analgesics, Opioid; Anesthetics, Diss | 2016 |
The effect of addition of ketamine to lidocaine on postoperative pain in rhinoplasties.
Topics: Anesthetics, Local; Double-Blind Method; Humans; Ketamine; Lidocaine; Pain, Postoperative; Rhinoplas | 2016 |
Preincisional and postoperative epidural morphine, ropivacaine, ketamine, and naloxone treatment for postoperative pain management in upper abdominal surgery.
Topics: Abdomen; Adult; Aged; Amides; Analgesia, Epidural; Analgesia, Patient-Controlled; Female; Humans; Ke | 2016 |
Prospective, randomized, and controlled trial on ketamine infusion during bilateral axillo-breast approach (BABA) robotic or endoscopic thyroidectomy: Effects on postoperative pain and recovery profiles: A consort compliant article.
Topics: Adult; Analgesics; Endoscopy; Female; Humans; Infusions, Intravenous; Ketamine; Male; Pain, Postoper | 2016 |
Intraoperative ketamine reduces immediate postoperative opioid consumption after spinal fusion surgery in chronic pain patients with opioid dependency: a randomized, blinded trial.
Topics: Adult; Aged; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Chronic Pain; Double-Bli | 2017 |
Intraoperative ketamine reduces immediate postoperative opioid consumption after spinal fusion surgery in chronic pain patients with opioid dependency: a randomized, blinded trial.
Topics: Adult; Aged; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Chronic Pain; Double-Bli | 2017 |
Intraoperative ketamine reduces immediate postoperative opioid consumption after spinal fusion surgery in chronic pain patients with opioid dependency: a randomized, blinded trial.
Topics: Adult; Aged; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Chronic Pain; Double-Bli | 2017 |
Intraoperative ketamine reduces immediate postoperative opioid consumption after spinal fusion surgery in chronic pain patients with opioid dependency: a randomized, blinded trial.
Topics: Adult; Aged; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Chronic Pain; Double-Bli | 2017 |
Intraoperative ketamine reduces immediate postoperative opioid consumption after spinal fusion surgery in chronic pain patients with opioid dependency: a randomized, blinded trial.
Topics: Adult; Aged; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Chronic Pain; Double-Bli | 2017 |
Intraoperative ketamine reduces immediate postoperative opioid consumption after spinal fusion surgery in chronic pain patients with opioid dependency: a randomized, blinded trial.
Topics: Adult; Aged; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Chronic Pain; Double-Bli | 2017 |
Intraoperative ketamine reduces immediate postoperative opioid consumption after spinal fusion surgery in chronic pain patients with opioid dependency: a randomized, blinded trial.
Topics: Adult; Aged; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Chronic Pain; Double-Bli | 2017 |
Intraoperative ketamine reduces immediate postoperative opioid consumption after spinal fusion surgery in chronic pain patients with opioid dependency: a randomized, blinded trial.
Topics: Adult; Aged; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Chronic Pain; Double-Bli | 2017 |
Intraoperative ketamine reduces immediate postoperative opioid consumption after spinal fusion surgery in chronic pain patients with opioid dependency: a randomized, blinded trial.
Topics: Adult; Aged; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Chronic Pain; Double-Bli | 2017 |
Intraoperative ketamine reduces immediate postoperative opioid consumption after spinal fusion surgery in chronic pain patients with opioid dependency: a randomized, blinded trial.
Topics: Adult; Aged; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Chronic Pain; Double-Bli | 2017 |
Intraoperative ketamine reduces immediate postoperative opioid consumption after spinal fusion surgery in chronic pain patients with opioid dependency: a randomized, blinded trial.
Topics: Adult; Aged; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Chronic Pain; Double-Bli | 2017 |
Intraoperative ketamine reduces immediate postoperative opioid consumption after spinal fusion surgery in chronic pain patients with opioid dependency: a randomized, blinded trial.
Topics: Adult; Aged; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Chronic Pain; Double-Bli | 2017 |
Intraoperative ketamine reduces immediate postoperative opioid consumption after spinal fusion surgery in chronic pain patients with opioid dependency: a randomized, blinded trial.
Topics: Adult; Aged; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Chronic Pain; Double-Bli | 2017 |
Intraoperative ketamine reduces immediate postoperative opioid consumption after spinal fusion surgery in chronic pain patients with opioid dependency: a randomized, blinded trial.
Topics: Adult; Aged; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Chronic Pain; Double-Bli | 2017 |
Intraoperative ketamine reduces immediate postoperative opioid consumption after spinal fusion surgery in chronic pain patients with opioid dependency: a randomized, blinded trial.
Topics: Adult; Aged; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Chronic Pain; Double-Bli | 2017 |
Intraoperative ketamine reduces immediate postoperative opioid consumption after spinal fusion surgery in chronic pain patients with opioid dependency: a randomized, blinded trial.
Topics: Adult; Aged; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Chronic Pain; Double-Bli | 2017 |
The effect of nephrostomy tract infiltration of ketamine on postoperative pain and peak expiratory flow rate in patients undergoing tubeless percutaneous nephrolithotomy: a prospective randomized clinical trial.
Topics: Adult; Analgesics; Anesthesia, Local; Female; Humans; Ketamine; Kidney Calculi; Male; Middle Aged; N | 2017 |
Ketamine spares morphine consumption after transthoracic lung and heart surgery without adverse hemodynamic effects.
Topics: Analgesia, Patient-Controlled; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Dr | 2008 |
Continuous low-dose ketamine improves the analgesic effects of fentanyl patient-controlled analgesia after cervical spine surgery.
Topics: Aged; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Female; Fentanyl; General Surge | 2008 |
Continuous low-dose ketamine improves the analgesic effects of fentanyl patient-controlled analgesia after cervical spine surgery.
Topics: Aged; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Female; Fentanyl; General Surge | 2008 |
Continuous low-dose ketamine improves the analgesic effects of fentanyl patient-controlled analgesia after cervical spine surgery.
Topics: Aged; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Female; Fentanyl; General Surge | 2008 |
Continuous low-dose ketamine improves the analgesic effects of fentanyl patient-controlled analgesia after cervical spine surgery.
Topics: Aged; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Female; Fentanyl; General Surge | 2008 |
Morphine with adjuvant ketamine vs higher dose of morphine alone for immediate postthoracotomy analgesia.
Topics: Aged; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, Dissociative; Coronary Artery | 2009 |
Morphine with adjuvant ketamine vs higher dose of morphine alone for immediate postthoracotomy analgesia.
Topics: Aged; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, Dissociative; Coronary Artery | 2009 |
Morphine with adjuvant ketamine vs higher dose of morphine alone for immediate postthoracotomy analgesia.
Topics: Aged; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, Dissociative; Coronary Artery | 2009 |
Morphine with adjuvant ketamine vs higher dose of morphine alone for immediate postthoracotomy analgesia.
Topics: Aged; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, Dissociative; Coronary Artery | 2009 |
Perioperative ketamine does not prevent chronic pain after thoracotomy.
Topics: Aged; Analgesics, Non-Narcotic; Anesthetics, Dissociative; Anesthetics, Local; Double-Blind Method; | 2009 |
Postoperative analgesia and early rehabilitation after total knee replacement: a comparison of continuous low-dose intravenous ketamine versus nefopam.
Topics: Aged; Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthesia, Gener | 2009 |
Intraoperative low-dose ketamine does not prevent a remifentanil-induced increase in morphine requirement after pediatric scoliosis surgery.
Topics: Adolescent; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Anesthetics, Intravenous; | 2008 |
Intraoperative low-dose ketamine does not prevent a remifentanil-induced increase in morphine requirement after pediatric scoliosis surgery.
Topics: Adolescent; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Anesthetics, Intravenous; | 2008 |
Intraoperative low-dose ketamine does not prevent a remifentanil-induced increase in morphine requirement after pediatric scoliosis surgery.
Topics: Adolescent; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Anesthetics, Intravenous; | 2008 |
Intraoperative low-dose ketamine does not prevent a remifentanil-induced increase in morphine requirement after pediatric scoliosis surgery.
Topics: Adolescent; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Anesthetics, Intravenous; | 2008 |
Epidural ketamine for postoperative analgesia in the elderly.
Topics: Abdomen; Aged; Analgesia, Epidural; Analgesics; Anesthetics, Local; Bupivacaine; Double-Blind Method | 2008 |
Does anesthetic induction for Cesarean section with a combination of ketamine and thiopentone confer any benefits over thiopentone or ketamine alone? A prospective randomized study.
Topics: Adolescent; Adult; Analgesia, Obstetrical; Anesthesia, General; Anesthesia, Obstetrical; Awareness; | 2009 |
[Balanced anesthesia with continuous ketamine reduces adverse effects of remifentanil].
Topics: Adjuvants, Anesthesia; Adult; Anesthesia, General; Anti-Inflammatory Agents, Non-Steroidal; Bradycar | 2008 |
The effect of intraarticular combinations of tramadol and ropivacaine with ketamine on postoperative pain after arthroscopic meniscectomy.
Topics: Adult; Amides; Analgesics; Analgesics, Opioid; Anesthetics, Local; Arthroscopy; Drug Therapy, Combin | 2010 |
Ketamine and lornoxicam for preventing a fentanyl-induced increase in postoperative morphine requirement.
Topics: Adult; Analgesics, Opioid; Anesthesia, Spinal; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind | 2008 |
The efficacy of preemptive ketamine and ropivacaine in pediatric patients: a placebo controlled, double-blind.
Topics: Amides; Analgesics, Opioid; Blood Pressure; Child; Child, Preschool; Double-Blind Method; Heart Rate | 2008 |
[Effect of ketamine on prevention of postmastectomy chronic pain. A pilot study].
Topics: Analgesics; Chronic Disease; Double-Blind Method; Feasibility Studies; Female; Humans; Ketamine; Mas | 2008 |
Intravenous ketamine plus midazolam vs. intravenous ketamine for sedation in lumbar puncture: a randomized controlled trial.
Topics: Adolescent; Anesthetics, Dissociative; Anesthetics, Intravenous; Child; Confidence Intervals; Dizzin | 2008 |
Ketamine has no effect on bispectral index during stable propofol-remifentanil anaesthesia.
Topics: Adult; Aged; Analgesics; Anesthetics, Combined; Anesthetics, Dissociative; Anesthetics, Intravenous; | 2009 |
Intraoperative ketamine may influence persistent pain following knee arthroplasty under combined general and spinal anaesthesia: a pilot study.
Topics: Adult; Aged; Anesthesia, General; Anesthesia, Spinal; Arthroplasty, Replacement, Knee; Female; Human | 2009 |
Assessment of combined local anesthesia and ketamine for pain, swelling, and trismus after surgical extraction of third molars.
Topics: Adolescent; Adult; Analgesics; Anesthetics, Combined; Anesthetics, Dissociative; Anesthetics, Local; | 2009 |
Clinical benefits related to the combination of ketamine with morphine for patient controlled analgesia after major abdominal surgery.
Topics: Abdomen; Analgesia, Patient-Controlled; Analgesics; Double-Blind Method; Drug Therapy, Combination; | 2008 |
Effects of perioperative intravenous low dose of ketamine on postoperative analgesia in children.
Topics: Anesthetics, Dissociative; Anesthetics, Intravenous; Child; Child, Preschool; Double-Blind Method; F | 2010 |
[Effects of patient-controlled analgesia with small dose ketamine combined with morphine and the influence thereof on plasma beta-endorphin level in patients after radical operation for esophageal carcinoma].
Topics: Adult; Aged; Analgesia, Patient-Controlled; beta-Endorphin; Esophageal Neoplasms; Female; Humans; Ke | 2009 |
[Prevention of the acute tolerence with fentanyl by ketamine].
Topics: Adolescent; Adult; Analgesics; Analgesics, Opioid; Drug Tolerance; Fentanyl; Humans; Ketamine; Middl | 2008 |
Remifentanil combined with low-dose ketamine for postoperative analgesia of lower limb fracture: a double-blind, controlled study.
Topics: Adult; Aged; Analgesia, Patient-Controlled; Double-Blind Method; Female; Fractures, Bone; Humans; Ke | 2009 |
Multimodal analgesia with gabapentin, ketamine and dexamethasone in combination with paracetamol and ketorolac after hip arthroplasty: a preliminary study.
Topics: Acetaminophen; Aged; Amines; Analgesia; Analgesics; Arthroplasty, Replacement, Hip; Cyclohexanecarbo | 2010 |
Multimodal analgesia with gabapentin, ketamine and dexamethasone in combination with paracetamol and ketorolac after hip arthroplasty: a preliminary study.
Topics: Acetaminophen; Aged; Amines; Analgesia; Analgesics; Arthroplasty, Replacement, Hip; Cyclohexanecarbo | 2010 |
Multimodal analgesia with gabapentin, ketamine and dexamethasone in combination with paracetamol and ketorolac after hip arthroplasty: a preliminary study.
Topics: Acetaminophen; Aged; Amines; Analgesia; Analgesics; Arthroplasty, Replacement, Hip; Cyclohexanecarbo | 2010 |
Multimodal analgesia with gabapentin, ketamine and dexamethasone in combination with paracetamol and ketorolac after hip arthroplasty: a preliminary study.
Topics: Acetaminophen; Aged; Amines; Analgesia; Analgesics; Arthroplasty, Replacement, Hip; Cyclohexanecarbo | 2010 |
Multimodal analgesia with gabapentin, ketamine and dexamethasone in combination with paracetamol and ketorolac after hip arthroplasty: a preliminary study.
Topics: Acetaminophen; Aged; Amines; Analgesia; Analgesics; Arthroplasty, Replacement, Hip; Cyclohexanecarbo | 2010 |
Multimodal analgesia with gabapentin, ketamine and dexamethasone in combination with paracetamol and ketorolac after hip arthroplasty: a preliminary study.
Topics: Acetaminophen; Aged; Amines; Analgesia; Analgesics; Arthroplasty, Replacement, Hip; Cyclohexanecarbo | 2010 |
Multimodal analgesia with gabapentin, ketamine and dexamethasone in combination with paracetamol and ketorolac after hip arthroplasty: a preliminary study.
Topics: Acetaminophen; Aged; Amines; Analgesia; Analgesics; Arthroplasty, Replacement, Hip; Cyclohexanecarbo | 2010 |
Multimodal analgesia with gabapentin, ketamine and dexamethasone in combination with paracetamol and ketorolac after hip arthroplasty: a preliminary study.
Topics: Acetaminophen; Aged; Amines; Analgesia; Analgesics; Arthroplasty, Replacement, Hip; Cyclohexanecarbo | 2010 |
Multimodal analgesia with gabapentin, ketamine and dexamethasone in combination with paracetamol and ketorolac after hip arthroplasty: a preliminary study.
Topics: Acetaminophen; Aged; Amines; Analgesia; Analgesics; Arthroplasty, Replacement, Hip; Cyclohexanecarbo | 2010 |
An intraoperative pre-incision single dose of intravenous ketamine does not have an effect on postoperative analgesic requirements under clinical conditions.
Topics: Analgesia; Analgesics; Analgesics, Opioid; Dose-Response Relationship, Drug; Double-Blind Method; Fe | 2009 |
Intravenous ketamine and local bupivacaine infiltration are effective as part of a multimodal regime for reducing post-tonsillectomy pain.
Topics: Adolescent; Analgesics; Bupivacaine; Child; Child, Preschool; Combined Modality Therapy; Demography; | 2009 |
A comparison of gabapentin and ketamine in acute and chronic pain after hysterectomy.
Topics: Acute Disease; Administration, Oral; Adult; Amines; Analgesia, Patient-Controlled; Analgesics; Analg | 2009 |
A comparison of gabapentin and ketamine in acute and chronic pain after hysterectomy.
Topics: Acute Disease; Administration, Oral; Adult; Amines; Analgesia, Patient-Controlled; Analgesics; Analg | 2009 |
A comparison of gabapentin and ketamine in acute and chronic pain after hysterectomy.
Topics: Acute Disease; Administration, Oral; Adult; Amines; Analgesia, Patient-Controlled; Analgesics; Analg | 2009 |
A comparison of gabapentin and ketamine in acute and chronic pain after hysterectomy.
Topics: Acute Disease; Administration, Oral; Adult; Amines; Analgesia, Patient-Controlled; Analgesics; Analg | 2009 |
The early and delayed analgesic effects of ketamine after total hip arthroplasty: a prospective, randomized, controlled, double-blind study.
Topics: Acetaminophen; Acute Disease; Adult; Aged; Analgesia; Analgesia, Patient-Controlled; Analgesics; Ana | 2009 |
The early and delayed analgesic effects of ketamine after total hip arthroplasty: a prospective, randomized, controlled, double-blind study.
Topics: Acetaminophen; Acute Disease; Adult; Aged; Analgesia; Analgesia, Patient-Controlled; Analgesics; Ana | 2009 |
The early and delayed analgesic effects of ketamine after total hip arthroplasty: a prospective, randomized, controlled, double-blind study.
Topics: Acetaminophen; Acute Disease; Adult; Aged; Analgesia; Analgesia, Patient-Controlled; Analgesics; Ana | 2009 |
The early and delayed analgesic effects of ketamine after total hip arthroplasty: a prospective, randomized, controlled, double-blind study.
Topics: Acetaminophen; Acute Disease; Adult; Aged; Analgesia; Analgesia, Patient-Controlled; Analgesics; Ana | 2009 |
Effects of ketamine added to ropivacaine in pediatric caudal block.
Topics: Amides; Analgesics; Anesthesia, Caudal; Anesthetics, Combined; Anesthetics, Local; Child, Preschool; | 2010 |
Remifentanil in combination with ketamine versus remifentanil in spinal fusion surgery--a double blind study.
Topics: Analgesics, Opioid; Anesthesia Recovery Period; Anesthetics, Combined; Anesthetics, Dissociative; An | 2010 |
[A combination of dexmedetomidine with ketamine and opioids results in significant inhibition of hemodynamic changes associated with laparoscopic cholecystectomy and in prolongation of postoperative analgesia].
Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthesia Recovery Period; Anesthetics, Combined; Ane | 2010 |
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical | 2010 |
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical | 2010 |
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical | 2010 |
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical | 2010 |
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical | 2010 |
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical | 2010 |
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical | 2010 |
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical | 2010 |
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical | 2010 |
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical | 2010 |
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical | 2010 |
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical | 2010 |
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical | 2010 |
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical | 2010 |
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical | 2010 |
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical | 2010 |
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical | 2010 |
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical | 2010 |
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical | 2010 |
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical | 2010 |
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical | 2010 |
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical | 2010 |
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical | 2010 |
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical | 2010 |
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical | 2010 |
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical | 2010 |
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical | 2010 |
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical | 2010 |
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical | 2010 |
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical | 2010 |
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical | 2010 |
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical | 2010 |
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical | 2010 |
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical | 2010 |
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical | 2010 |
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical | 2010 |
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical | 2010 |
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical | 2010 |
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical | 2010 |
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical | 2010 |
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical | 2010 |
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical | 2010 |
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical | 2010 |
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical | 2010 |
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical | 2010 |
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical | 2010 |
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical | 2010 |
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical | 2010 |
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical | 2010 |
Low-dose ketamine via intravenous patient-controlled analgesia device after various transthoracic procedures improves analgesia and patient and family satisfaction.
Topics: Aged; Analgesia; Analgesia, Patient-Controlled; Analgesics; Analysis of Variance; Clinical Nursing R | 2010 |
Intraoperative infusion of S(+)-ketamine enhances post-thoracotomy pain control compared with perioperative parecoxib when used in conjunction with thoracic paravertebral ropivacaine infusion.
Topics: Adult; Aged; Amides; Drug Therapy, Combination; Female; Humans; Infusions, Intravenous; Injections, | 2011 |
Regional intravenous anesthesia in knee arthroscopy.
Topics: Adult; Aged; Analgesics, Opioid; Anesthesia, Conduction; Anesthetics, Intravenous; Arthroscopy; Body | 2010 |
Multimodal analgesic approach incorporating paravertebral blocks for open radical retropubic prostatectomy: a randomized double-blind placebo-controlled study.
Topics: Adult; Aged; Aged, 80 and over; Analgesia, Patient-Controlled; Analgesics; Celecoxib; Double-Blind M | 2011 |
Preemptive low-dose epidural ketamine for preventing chronic postthoracotomy pain: a prospective, double-blinded, randomized, clinical trial.
Topics: Adult; Aged; Aged, 80 and over; Analgesia, Epidural; Analgesics; Dose-Response Relationship, Drug; D | 2011 |
Effects of midazolam/low-dose ketamine conscious intravenous sedation on pain, swelling, and trismus after surgical extraction of third molars.
Topics: Adult; Anesthetics, Dissociative; Anesthetics, Intravenous; Anesthetics, Local; Carticaine; Consciou | 2011 |
Low-dose ketamine with multimodal postcesarean delivery analgesia: a randomized controlled trial.
Topics: Adult; Analgesia, Obstetrical; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthesia, Spinal | 2011 |
Effect of adding ketamine to pethidine on postoperative pain in patients undergoing major abdominal operations: a double blind randomized controlled trial.
Topics: Abdomen; Adult; Analgesics; Double-Blind Method; Female; Humans; Ketamine; Male; Meperidine; Middle | 2010 |
The ED50 and ED95 of ketamine for prevention of postoperative hyperalgesia after remifentanil-based anaesthesia in patients undergoing laparoscopic cholecystectomy.
Topics: Analgesics; Anesthetics, Intravenous; Cholecystectomy, Laparoscopic; Dose-Response Relationship, Dru | 2011 |
Ketamine as an adjunct to fentanyl improves postoperative analgesia and hastens discharge in children following tonsillectomy - a prospective, double-blinded, randomized study.
Topics: Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Dissociative; Anesthetics, Intravenous | 2011 |
Intra- and postoperative very low dose intravenous ketamine infusion does not increase pain relief after major spine surgery in patients with preoperative narcotic analgesic intake.
Topics: Adult; Aged; Analgesia; Analgesics; Double-Blind Method; Female; Humans; Infusions, Intravenous; Ket | 2011 |
Repeated and escalating preoperative subanesthetic doses of ketamine for postoperative pain control in patients undergoing tumor resection: a randomized, placebo-controlled, double-blind trial.
Topics: Adolescent; Adult; Aged; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Dose-Respons | 2011 |
Intravenous and peritonsillar infiltration of ketamine for postoperative pain after adenotonsillectomy: a randomized placebo-controlled clinical trial.
Topics: Adenoidectomy; Adolescent; Analysis of Variance; Anesthetics, Dissociative; Antiemetics; Anxiety; Ch | 2011 |
A randomized, double blind, placebo controlled clinical trial of the preoperative use of ketamine for reducing inflammation and pain after thoracic surgery.
Topics: Aged; Analgesics; C-Reactive Protein; Double-Blind Method; Female; Humans; Inflammation; Interleukin | 2011 |
Pre-incisional analgesia with intravenous or subcutaneous infiltration of ketamine reduces postoperative pain in patients after open cholecystectomy: a randomized, double-blind, placebo-controlled study.
Topics: Adolescent; Adult; Analgesia; Anesthesia, Local; Anesthetics, Dissociative; Anesthetics, Local; Chol | 2011 |
An intraoperative small dose of ketamine prevents remifentanil-induced postanesthetic shivering.
Topics: Adult; Analgesics, Opioid; Anesthesia Recovery Period; Chi-Square Distribution; Drug Administration | 2011 |
Low-dose intravenous ketamine and clonidine for poor postoperative opioid responsiveness: a double blind randomized study.
Topics: Analgesics; Analgesics, Opioid; Clonidine; Dose-Response Relationship, Drug; Double-Blind Method; Dr | 2011 |
Preemptive peritonsillar ketamine infiltration: postoperative analgesic efficacy versus meperidine.
Topics: Adenoidectomy; Adolescent; Analgesics, Opioid; Bupivacaine; Child; Child, Preschool; Female; Humans; | 2011 |
Comparison of ketamine and fentanyl for postoperative pain relief in children following adenotonsillectomy.
Topics: Adenoidectomy; Analgesics; Child; Child, Preschool; Double-Blind Method; Fentanyl; Humans; Ketamine; | 2011 |
The effect of orally administered ketamine on requirement for anesthetics and postoperative pain in mandibular molar teeth with irreversible pulpitis.
Topics: Adjuvants, Anesthesia; Administration, Oral; Adolescent; Adult; Analgesics; Anesthesia, Dental; Anes | 2011 |
Comparative clinical study of effect of neostigmine and ketamine for postoperative analgesia.
Topics: Adolescent; Adult; Analgesia, Epidural; Analgesics; Anesthetics, Local; Bupivacaine; Cholinesterase | 2011 |
Effect of three different doses of ketamine prior to general anaesthesia on postoperative pain following Caesarean delivery: a prospective randomized study.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthesia, General; Anesthesia, Obstetric | 2012 |
Clinical efficacy and safety of dexmedetomidine used as a preanesthetic prior to general anesthesia in cats.
Topics: Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Combined; Animals; Blood Gas Analysis; | 2012 |
Beneficial effects of adding ketamine to intravenous patient-controlled analgesia with fentanyl after the Nuss procedure in pediatric patients.
Topics: Analgesia, Patient-Controlled; Analgesics; Child; Double-Blind Method; Female; Fentanyl; Funnel Ches | 2012 |
A study of low-dose S-ketamine infusion as "preventive" pain treatment for cesarean section with spinal anesthesia: benefits and side effects.
Topics: Adjuvants, Anesthesia; Adult; Analgesics, Opioid; Anesthesia, Spinal; Anesthetics, Dissociative; Ane | 2012 |
A study of low-dose S-ketamine infusion as "preventive" pain treatment for cesarean section with spinal anesthesia: benefits and side effects.
Topics: Adjuvants, Anesthesia; Adult; Analgesics, Opioid; Anesthesia, Spinal; Anesthetics, Dissociative; Ane | 2012 |
A study of low-dose S-ketamine infusion as "preventive" pain treatment for cesarean section with spinal anesthesia: benefits and side effects.
Topics: Adjuvants, Anesthesia; Adult; Analgesics, Opioid; Anesthesia, Spinal; Anesthetics, Dissociative; Ane | 2012 |
A study of low-dose S-ketamine infusion as "preventive" pain treatment for cesarean section with spinal anesthesia: benefits and side effects.
Topics: Adjuvants, Anesthesia; Adult; Analgesics, Opioid; Anesthesia, Spinal; Anesthetics, Dissociative; Ane | 2012 |
Esmolol versus ketamine-remifentanil combination for early postoperative analgesia after laparoscopic cholecystectomy: a randomized controlled trial.
Topics: Adrenergic beta-1 Receptor Antagonists; Adult; Aged; Analgesics; Analgesics, Opioid; Cholecystectomy | 2012 |
Esmolol versus ketamine-remifentanil combination for early postoperative analgesia after laparoscopic cholecystectomy: a randomized controlled trial.
Topics: Adrenergic beta-1 Receptor Antagonists; Adult; Aged; Analgesics; Analgesics, Opioid; Cholecystectomy | 2012 |
Esmolol versus ketamine-remifentanil combination for early postoperative analgesia after laparoscopic cholecystectomy: a randomized controlled trial.
Topics: Adrenergic beta-1 Receptor Antagonists; Adult; Aged; Analgesics; Analgesics, Opioid; Cholecystectomy | 2012 |
Esmolol versus ketamine-remifentanil combination for early postoperative analgesia after laparoscopic cholecystectomy: a randomized controlled trial.
Topics: Adrenergic beta-1 Receptor Antagonists; Adult; Aged; Analgesics; Analgesics, Opioid; Cholecystectomy | 2012 |
Esmolol versus ketamine-remifentanil combination for early postoperative analgesia after laparoscopic cholecystectomy: a randomized controlled trial.
Topics: Adrenergic beta-1 Receptor Antagonists; Adult; Aged; Analgesics; Analgesics, Opioid; Cholecystectomy | 2012 |
Esmolol versus ketamine-remifentanil combination for early postoperative analgesia after laparoscopic cholecystectomy: a randomized controlled trial.
Topics: Adrenergic beta-1 Receptor Antagonists; Adult; Aged; Analgesics; Analgesics, Opioid; Cholecystectomy | 2012 |
Esmolol versus ketamine-remifentanil combination for early postoperative analgesia after laparoscopic cholecystectomy: a randomized controlled trial.
Topics: Adrenergic beta-1 Receptor Antagonists; Adult; Aged; Analgesics; Analgesics, Opioid; Cholecystectomy | 2012 |
Esmolol versus ketamine-remifentanil combination for early postoperative analgesia after laparoscopic cholecystectomy: a randomized controlled trial.
Topics: Adrenergic beta-1 Receptor Antagonists; Adult; Aged; Analgesics; Analgesics, Opioid; Cholecystectomy | 2012 |
Esmolol versus ketamine-remifentanil combination for early postoperative analgesia after laparoscopic cholecystectomy: a randomized controlled trial.
Topics: Adrenergic beta-1 Receptor Antagonists; Adult; Aged; Analgesics; Analgesics, Opioid; Cholecystectomy | 2012 |
Effect of ketamine on bispectral index during propofol--fentanyl anesthesia: a randomized controlled study.
Topics: Adolescent; Adult; Aged; Anesthetics, Dissociative; Anesthetics, Intravenous; Blood Pressure; Consci | 2011 |
S(+)-ketamine for control of perioperative pain and prevention of post thoracotomy pain syndrome: a randomized, double-blind study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesia, Epidural; Anesthetics, Dissociative; Double-B | 2012 |
Analgesic effects of ketamine infusion on postoperative pain after fusion and instrumentation of the lumbar spine: a prospective randomized clinical trial.
Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Double-Blind Method; Female; Humans; Infusions, Intrave | 2012 |
Assessing intravenous ketamine and intravenous dexamethasone separately and in combination for early oral intake, vomiting and postoperative pain relief in children following tonsillectomy.
Topics: Analgesics; Antiemetics; Child; Child, Preschool; Dexamethasone; Eating; Female; Humans; Injections, | 2012 |
Comparison of peritonsillar infiltration effects of ketamine and tramadol on post tonsillectomy pain: a double-blinded randomized placebo-controlled clinical trial.
Topics: Analgesics, Opioid; Anesthetics, Dissociative; Child; Child, Preschool; Double-Blind Method; Female; | 2012 |
Intravenous ketamine compared with diclofenac suppository in suppressing acute postoperative pain in women undergoing gynecologic laparoscopy.
Topics: Adult; Analgesics; Anesthesia, General; Diclofenac; Dose-Response Relationship, Drug; Double-Blind M | 2012 |
Low-dose intravenous ketamine improves postoperative analgesia after caesarean delivery with spinal bupivacaine in African parturients.
Topics: Adult; Analgesics; Anesthesia, Obstetrical; Anesthesia, Spinal; Anesthetics, Local; Bupivacaine; Ces | 2012 |
Preemptive use of diclofenac in combination with ketamine in patients undergoing laparoscopic cholecystectomy: a randomized, double-blind, placebo-controlled study.
Topics: Abdominal Pain; Adolescent; Adult; Aged; Analgesics, Opioid; Cholecystectomy, Laparoscopic; Diclofen | 2012 |
Analgesic effect of ketamine and morphine after tonsillectomy in children.
Topics: Analgesics; Child; Double-Blind Method; Female; Humans; Ketamine; Male; Morphine; Pain, Postoperativ | 2012 |
Is there any benefit to adding intravenous ketamine to patient-controlled epidural analgesia after thoracic surgery? A randomized double-blind study.
Topics: Adult; Aged; Aged, 80 and over; Amides; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesi | 2012 |
Is there any benefit to adding intravenous ketamine to patient-controlled epidural analgesia after thoracic surgery? A randomized double-blind study.
Topics: Adult; Aged; Aged, 80 and over; Amides; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesi | 2012 |
Is there any benefit to adding intravenous ketamine to patient-controlled epidural analgesia after thoracic surgery? A randomized double-blind study.
Topics: Adult; Aged; Aged, 80 and over; Amides; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesi | 2012 |
Is there any benefit to adding intravenous ketamine to patient-controlled epidural analgesia after thoracic surgery? A randomized double-blind study.
Topics: Adult; Aged; Aged, 80 and over; Amides; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesi | 2012 |
The perioperative combination of methadone and ketamine reduces post-operative opioid usage compared with methadone alone.
Topics: Adult; Aged; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthesia, General; Anesthetics, Di | 2012 |
The effect of a small dose of ketamine on postoperative analgesia and cytokine changes after laparoscopic cholecystectomy.
Topics: Analgesics; Cholecystectomy, Laparoscopic; Enzyme-Linked Immunosorbent Assay; Female; Humans; Interl | 2012 |
The effect of perioperative intravenous lidocaine and ketamine on recovery after abdominal hysterectomy.
Topics: Adult; Anesthesia Recovery Period; Double-Blind Method; Drug Therapy, Combination; Female; Humans; H | 2012 |
Is S-ketamine with or without magnesium sulphate an alternative for postoperative pain treatment? Randomised study.
Topics: Double-Blind Method; Follow-Up Studies; Humans; Ketamine; Magnesium Sulfate; Pain, Postoperative; Re | 2013 |
The role of pre-induction ketamine in the management of postoperative pain in patients undergoing elective gynaecological surgery at the University Hospital of the West Indies.
Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Elective Surgical Procedures; Female; Gynecologic Surgi | 2012 |
Comparison of the effects of dexmedetomidine, ketamine, and placebo on emergence agitation after strabismus surgery in children.
Topics: Anesthesia Recovery Period; Anesthetics, Dissociative; Anesthetics, Inhalation; Child; Child, Presch | 2013 |
No enhancement of sensory and motor blockade by ketamine added to ropivacaine interscalene brachial plexus blockade.
Topics: Adult; Amides; Analgesics; Anesthetics, Combined; Anesthetics, Local; Brachial Plexus; Double-Blind | 2002 |
A comparative study on the analgesic effect of tramadol, tramadol plus magnesium, and tramadol plus ketamine for postoperative pain management after major abdominal surgery.
Topics: Abdomen; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Anesthetics, Combined; Doubl | 2002 |
[Effect of low-dose intravenous ketamine in postoperative analgesia for hysterectomy and adnexectomy].
Topics: Adolescent; Adult; Aged; Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; Anesthesia Recover | 2002 |
The comparison of caudal ketamine, alfentanil and ketamine plus alfentanil administration for postoperative analgesia in children.
Topics: Alfentanil; Analgesia, Epidural; Analgesics; Analgesics, Opioid; Anesthetics, Combined; Child; Child | 2002 |
Use of low doses of ketamine administered by constant rate infusion as an adjunct for postoperative analgesia in dogs.
Topics: Amputation, Surgical; Analgesia; Analgesics; Animals; Dogs; Double-Blind Method; Forelimb; Infusions | 2002 |
Can ketamine potentiate the analgesic effect of epidural morphine, preincisional or postincisional administration?
Topics: Adult; Analgesia, Epidural; Analgesics; Analgesics, Opioid; Analysis of Variance; Chi-Square Distrib | 2002 |
Patient-controlled bupivacaine wound instillation following cesarean section: the lack of efficacy of adjuvant ketamine.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics; Anesthetics, Local; Bupivacaine; Cesarean Section; | 2002 |
[Recovery from anaesthesia and incidence and intensity of postoperative nausea and vomiting following a total intravenous anaesthesia (TIVA) with S-(+)-ketamine/propofol compared to alfentanil/propofol].
Topics: Adolescent; Aged; Alfentanil; Anesthesia Recovery Period; Anesthesia, Intravenous; Anesthetics, Diss | 2002 |
A comparison between local anaesthetic dorsal nerve block and caudal bupivacaine with ketamine for paediatric circumcision.
Topics: Anesthetics, Local; Bupivacaine; Child; Child, Preschool; Circumcision, Male; Humans; Infant; Ketami | 2003 |
Postoperative pain relief after hepatic resection in cirrhotic patients: the efficacy of a single small dose of ketamine plus morphine epidurally.
Topics: Acetaminophen; Adult; Aged; Analgesia, Epidural; Analgesics; Analgesics, Opioid; Anesthetics, Dissoc | 2003 |
A single small dose of postoperative ketamine provides rapid and sustained improvement in morphine analgesia in the presence of morphine-resistant pain.
Topics: Analgesics, Opioid; Anesthesia, General; Blood Gas Analysis; Double-Blind Method; Drug Resistance; D | 2003 |
A single small dose of postoperative ketamine provides rapid and sustained improvement in morphine analgesia in the presence of morphine-resistant pain.
Topics: Analgesics, Opioid; Anesthesia, General; Blood Gas Analysis; Double-Blind Method; Drug Resistance; D | 2003 |
A single small dose of postoperative ketamine provides rapid and sustained improvement in morphine analgesia in the presence of morphine-resistant pain.
Topics: Analgesics, Opioid; Anesthesia, General; Blood Gas Analysis; Double-Blind Method; Drug Resistance; D | 2003 |
A single small dose of postoperative ketamine provides rapid and sustained improvement in morphine analgesia in the presence of morphine-resistant pain.
Topics: Analgesics, Opioid; Anesthesia, General; Blood Gas Analysis; Double-Blind Method; Drug Resistance; D | 2003 |
Caudal bupivacaine and s(+)-ketamine for postoperative analgesia in children.
Topics: Analgesics; Anesthesia, Caudal; Anesthesia, General; Anesthetics, Local; Bupivacaine; Child; Child, | 2003 |
Ketamine reduces swallowing-evoked pain after paediatric tonsillectomy.
Topics: Analgesics, Opioid; Anesthesia, General; Anesthetics, Dissociative; Anti-Inflammatory Agents, Non-St | 2003 |
Postoperative pain management with intravenous patient-controlled morphine: comparison of the effect of adding magnesium or ketamine.
Topics: Abdomen; Analgesia, Patient-Controlled; Analgesics, Opioid; Analysis of Variance; Anesthetics, Combi | 2003 |
Does ketamine or magnesium affect posttonsillectomy pain in children?
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthetics, Dissociative; Child; Child | 2003 |
Double-blind randomized placebo-controlled trial of the effect of ketamine on postoperative morphine consumption in children following appendicectomy.
Topics: Adolescent; Analgesics, Opioid; Appendectomy; Child; Double-Blind Method; Excitatory Amino Acid Anta | 2003 |
Intra-articular (IA) catheter administration of postoperative analgesics. A new trial design allows evaluation of baseline pain, demonstrates large variation in need of analgesics, and finds no analgesic effect of IA ketamine compared with IA saline.
Topics: Analgesics; Catheters, Indwelling; Double-Blind Method; Female; Humans; Injections, Intra-Articular; | 2003 |
The effects of small-dose ketamine on morphine consumption in surgical intensive care unit patients after major abdominal surgery.
Topics: Abdomen; Aged; Analgesics, Opioid; Anesthetics, Dissociative; Critical Care; Double-Blind Method; Dr | 2003 |
Intraoperative intravenous ketamine in combination with epidural analgesia: postoperative analgesia after renal surgery.
Topics: Adult; Analgesia, Epidural; Analgesics, Opioid; Anesthesia, General; Anesthetics, Dissociative; Anes | 2003 |
Interaction between epidurally administered ketamine and pethidine in dogs.
Topics: Analgesics; Analgesics, Opioid; Animals; Dogs; Drug Interactions; Female; Heart Rate; Injections, Ep | 2003 |
Comparison of remifentanil versus ketamine for paediatric day case adenoidectomy.
Topics: Adenoidectomy; Ambulatory Surgical Procedures; Analgesics, Opioid; Anesthesia Recovery Period; Anest | 2003 |
Preincisional treatment to prevent pain after ambulatory hernia surgery.
Topics: Adolescent; Adult; Aged; Ambulatory Surgical Procedures; Anti-Inflammatory Agents, Non-Steroidal; Cy | 2003 |
Double-blind randomized controlled trial of caudal versus intravenous S(+)-ketamine for supplementation of caudal analgesia in children.
Topics: Analgesia, Epidural; Analgesics; Anesthesia, Caudal; Anesthesia, General; Anesthetics, Dissociative; | 2004 |
A randomised, controlled study of peri-operative low dose s(+)-ketamine in combination with postoperative patient-controlled s(+)-ketamine and morphine after radical prostatectomy.
Topics: Adult; Aged; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Double-Blind Method; Dru | 2004 |
The efficacy of intra-articular ketamine for postoperative analgesia in outpatient arthroscopic surgery.
Topics: Adolescent; Adult; Ambulatory Surgical Procedures; Analgesics; Analysis of Variance; Anesthetics, Lo | 2004 |
Preoperative ketamine improves postoperative analgesia after gynecologic laparoscopic surgery.
Topics: Adult; Analgesics, Opioid; Double-Blind Method; Excitatory Amino Acid Antagonists; Female; Gynecolog | 2004 |
Preoperative ketamine improves postoperative analgesia after gynecologic laparoscopic surgery.
Topics: Adult; Analgesics, Opioid; Double-Blind Method; Excitatory Amino Acid Antagonists; Female; Gynecolog | 2004 |
Preoperative ketamine improves postoperative analgesia after gynecologic laparoscopic surgery.
Topics: Adult; Analgesics, Opioid; Double-Blind Method; Excitatory Amino Acid Antagonists; Female; Gynecolog | 2004 |
Preoperative ketamine improves postoperative analgesia after gynecologic laparoscopic surgery.
Topics: Adult; Analgesics, Opioid; Double-Blind Method; Excitatory Amino Acid Antagonists; Female; Gynecolog | 2004 |
Improvement of pain treatment after major abdominal surgery by intravenous S+-ketamine.
Topics: Abdomen; Adult; Affect; Aged; Analgesics, Opioid; Anesthesia Recovery Period; Anesthesia, Epidural; | 2004 |
Oral ketamine premedication can prevent emergence agitation in children after desflurane anaesthesia.
Topics: Adenoidectomy; Administration, Oral; Analgesics, Opioid; Anesthesia Recovery Period; Anesthetics, In | 2004 |
Evaluation of the neuroprotective effects of S(+)-ketamine during open-heart surgery.
Topics: Aged; Cardiopulmonary Bypass; Chi-Square Distribution; Cognition Disorders; Female; Humans; Ketamine | 2004 |
Comparison of caudal ropivacaine, ropivacaine plus ketamine and ropivacaine plus tramadol administration for postoperative analgesia in children.
Topics: Amides; Analgesia, Epidural; Analgesics, Opioid; Anesthetics, Local; Child; Child, Preschool; Double | 2004 |
Analgesia for adenotonsillectomy in children: a comparison of morphine, ketamine and tramadol.
Topics: Adenoidectomy; Analgesia; Analgesics, Opioid; Child; Child, Preschool; Double-Blind Method; Female; | 2004 |
Effect of pre-emptive ketamine on sensory changes and postoperative pain after thoracotomy: comparison of epidural and intramuscular routes.
Topics: Adult; Aged; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Dou | 2004 |
Perioperative intravenous ketamine infusion for the prevention of persistent post-amputation pain: a randomized, controlled trial.
Topics: Aged; Amputation, Surgical; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Anesthesi | 2004 |
Pre-emptive analgesia using intravenous fentanyl plus low-dose ketamine for radical prostatectomy under general anesthesia does not produce short-term or long-term reductions in pain or analgesic use.
Topics: Aged; Analgesia; Analysis of Variance; Anesthesia, General; Chi-Square Distribution; Double-Blind Me | 2004 |
Caudal analgesia in children: S(+)-ketamine vs S(+)-ketamine plus clonidine.
Topics: Adrenergic alpha-Agonists; Analgesia; Anesthesia Recovery Period; Anesthesia, Caudal; Anesthetics, D | 2004 |
S(+)-ketamine as an analgesic adjunct reduces opioid consumption after cardiac surgery.
Topics: Aged; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, Dissociative; Cardiac Surgical | 2004 |
Preemptive ketamine during general anesthesia for postoperative analgesia in patients undergoing laparoscopic cholecystectomy.
Topics: Adult; Aged; Analgesics, Opioid; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Disso | 2004 |
Nefopam and ketamine comparably enhance postoperative analgesia.
Topics: Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthetics, Dissociative; Do | 2005 |
Small-dose ketamine infusion improves postoperative analgesia and rehabilitation after total knee arthroplasty.
Topics: Aged; Analgesics, Opioid; Anesthetics, Dissociative; Arthroplasty, Replacement, Knee; Double-Blind M | 2005 |
Intranasal sufentanil/midazolam versus ketamine/midazolam for analgesia/sedation in the pediatric population prior to undergoing multiple dental extractions under general anesthesia: a prospective, double-blind, randomized comparison.
Topics: Administration, Intranasal; Analgesics; Anesthesia, Dental; Anesthesia, General; Anesthetics, Combin | 2004 |
Caudal additives for postoperative pain management in children: S(+)-ketamine and neostigmine.
Topics: Analgesics; Anesthesia, Caudal; Anesthesia, General; Anesthetics, Combined; Anesthetics, Inhalation; | 2005 |
Analgesic effects of epidurally administered levogyral ketamine alone or in combination with morphine on intraoperative and postoperative pain in dogs undergoing ovariohysterectomy.
Topics: Analgesia, Epidural; Analgesics; Animals; Dog Diseases; Dogs; Drug Therapy, Combination; Female; Hys | 2005 |
[Intra-operative ketamine administration reduced the level of post-thoracotomy pain].
Topics: Aged; Excitatory Amino Acid Antagonists; Female; Humans; Infusions, Intravenous; Intraoperative Care | 2005 |
Small-dose ketamine decreases postoperative morphine requirements.
Topics: Abdomen; Adult; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Dose-Response Relatio | 2004 |
The combination of epidural clonidine and S(+)-ketamine did not enhance analgesic efficacy beyond that for each individual drug in adult orthopedic surgery.
Topics: Adult; Aged; Analgesia, Epidural; Analgesics; Clonidine; Double-Blind Method; Drug Synergism; Female | 2005 |
Efficacy of prophylactic ketamine in preventing postoperative shivering.
Topics: Adolescent; Adult; Aged; Anesthesia, General; Anesthetics, Dissociative; Chi-Square Distribution; Do | 2005 |
Intraoperative low-dose S-ketamine has no preventive effects on postoperative pain and morphine consumption after major urological surgery in children.
Topics: Alfentanil; Analgesics, Opioid; Anesthesia, General; Anesthetics, Dissociative; Child; Child, Presch | 2005 |
Caudal additives in pediatrics: a comparison among midazolam, ketamine, and neostigmine coadministered with bupivacaine.
Topics: Anesthesia Recovery Period; Anesthesia, Caudal; Anesthesia, General; Anesthetics, Intravenous; Anest | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.
Topics: Adult; Aged; Female; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Postoperative; Piperid | 2005 |
Low-dose ketamine failed to spare morphine after a remifentanil-based anaesthesia for ear, nose and throat surgery.
Topics: Aged; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthesia, Intravenous; Anesthetics, Disso | 2005 |
The persisting analgesic effect of low-dose intravenous ketamine after spinal anaesthesia for caesarean section.
Topics: Adjuvants, Anesthesia; Adult; Anesthesia, Obstetrical; Anesthesia, Spinal; Anesthetics, Dissociative | 2005 |
Magnesium sulfate pretreatment reduces myoclonus after etomidate.
Topics: Adult; Anesthesia, Intravenous; Anesthetics, Intravenous; Anticonvulsants; Depression, Chemical; Dou | 2005 |
Bupivacaine/ketamine is superior to intra-articular ketamine analgesia following arthroscopic knee surgery.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthetics, Dissociative; Anest | 2005 |
Intraoperative epidural analgesia combined with ketamine provides effective preventive analgesia in patients undergoing major digestive surgery.
Topics: Adult; Aged; Analgesia, Epidural; Colonic Neoplasms; Double-Blind Method; Female; Humans; Hyperalges | 2005 |
Intraoperative epidural analgesia combined with ketamine provides effective preventive analgesia in patients undergoing major digestive surgery.
Topics: Adult; Aged; Analgesia, Epidural; Colonic Neoplasms; Double-Blind Method; Female; Humans; Hyperalges | 2005 |
Intraoperative epidural analgesia combined with ketamine provides effective preventive analgesia in patients undergoing major digestive surgery.
Topics: Adult; Aged; Analgesia, Epidural; Colonic Neoplasms; Double-Blind Method; Female; Humans; Hyperalges | 2005 |
Intraoperative epidural analgesia combined with ketamine provides effective preventive analgesia in patients undergoing major digestive surgery.
Topics: Adult; Aged; Analgesia, Epidural; Colonic Neoplasms; Double-Blind Method; Female; Humans; Hyperalges | 2005 |
Comparison of the effect of ketamine added to bupivacaine and ropivacaine, on stress hormone levels and the duration of caudal analgesia.
Topics: Amides; Anesthesia, Caudal; Anesthetics, Dissociative; Anesthetics, Local; Blood Glucose; Bupivacain | 2005 |
[Postoperative pain management using subcutaneous fentanyl and ketamine after abdominal gynecologic surgery].
Topics: Adult; Aged; Analgesics, Opioid; Anesthesia, General; Female; Fentanyl; Gynecologic Surgical Procedu | 2005 |
Peroperative ketamine and morphine for postoperative pain control after lumbar disk surgery.
Topics: Adult; Analgesics, Opioid; Anesthetics, Dissociative; Diskectomy; Dose-Response Relationship, Drug; | 2006 |
Effects of preincisional ketamine treatment on natural killer cell activity and postoperative pain management after oral maxillofacial surgery.
Topics: Adolescent; Adult; Aged; Analgesics; Female; Humans; Ketamine; Killer Cells, Natural; Male; Middle A | 2005 |
The influence of timing of systemic ketamine administration on postoperative morphine consumption.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Dose-Response Relationship, Dr | 2005 |
Comparison of caudal ketamine with lidocaine or tramadol administration for postoperative analgesia of hypospadias surgery in children.
Topics: Analgesics; Analgesics, Opioid; Anesthesia, Caudal; Anesthetics, Local; Blood Pressure; Child, Presc | 2006 |
Lack of a pre-emptive effect of low-dose ketamine on postoperative pain following oral surgery.
Topics: Adolescent; Adult; Analgesics; Anesthesia, General; Double-Blind Method; Female; Humans; Ketamine; M | 2006 |
[The effects of ketamine preemptive analgesia on postoperative pain in patients undergoing a hysterectomy].
Topics: Adult; Analgesia, Patient-Controlled; Analgesics; Anesthesia, General; Double-Blind Method; Female; | 2006 |
Ketamine for treatment of catheter related bladder discomfort: a prospective, randomized, placebo controlled and double blind study.
Topics: Adult; Analgesics; Double-Blind Method; Female; Humans; Intraoperative Care; Ketamine; Male; Middle | 2006 |
The preemptive use of diclofenac sodium in combination with ketamine and remifentanil does not enhance postoperative analgesia after laparoscopic gynecological procedures.
Topics: Adult; Analgesics, Opioid; Anesthetics, Dissociative; Anti-Inflammatory Agents, Non-Steroidal; Diclo | 2006 |
[Addition of ketamine infusion to patient controlled analgesia with intravenous morphine after abdominal hysterectomy].
Topics: Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Drug Therapy, Combination; Female; Hu | 2006 |
Low-dose intravenous ketamine potentiates epidural analgesia after thoracotomy.
Topics: Aged; Aged, 80 and over; Analgesia, Epidural; Analgesics; Double-Blind Method; Drug Synergism; Femal | 2006 |
Low-dose intravenous ketamine potentiates epidural analgesia after thoracotomy.
Topics: Aged; Aged, 80 and over; Analgesia, Epidural; Analgesics; Double-Blind Method; Drug Synergism; Femal | 2006 |
Low-dose intravenous ketamine potentiates epidural analgesia after thoracotomy.
Topics: Aged; Aged, 80 and over; Analgesia, Epidural; Analgesics; Double-Blind Method; Drug Synergism; Femal | 2006 |
Low-dose intravenous ketamine potentiates epidural analgesia after thoracotomy.
Topics: Aged; Aged, 80 and over; Analgesia, Epidural; Analgesics; Double-Blind Method; Drug Synergism; Femal | 2006 |
Low-dose intravenous ketamine potentiates epidural analgesia after thoracotomy.
Topics: Aged; Aged, 80 and over; Analgesia, Epidural; Analgesics; Double-Blind Method; Drug Synergism; Femal | 2006 |
Low-dose intravenous ketamine potentiates epidural analgesia after thoracotomy.
Topics: Aged; Aged, 80 and over; Analgesia, Epidural; Analgesics; Double-Blind Method; Drug Synergism; Femal | 2006 |
Low-dose intravenous ketamine potentiates epidural analgesia after thoracotomy.
Topics: Aged; Aged, 80 and over; Analgesia, Epidural; Analgesics; Double-Blind Method; Drug Synergism; Femal | 2006 |
Low-dose intravenous ketamine potentiates epidural analgesia after thoracotomy.
Topics: Aged; Aged, 80 and over; Analgesia, Epidural; Analgesics; Double-Blind Method; Drug Synergism; Femal | 2006 |
Low-dose intravenous ketamine potentiates epidural analgesia after thoracotomy.
Topics: Aged; Aged, 80 and over; Analgesia, Epidural; Analgesics; Double-Blind Method; Drug Synergism; Femal | 2006 |
Effect of an intravenous single dose of ketamine on postoperative pain in tonsillectomy patients.
Topics: Analgesia; Analgesics; Blood Pressure; Child; Child, Preschool; Heart Rate; Humans; Injections, Intr | 2006 |
[Has ketamine preemptive analgesic effect in patients undergoing abdominal hysterectomy?].
Topics: Analgesics; Female; Humans; Hysterectomy; Ketamine; Middle Aged; Pain Measurement; Pain, Postoperati | 2006 |
[Low-dose ketamine combined with fentanyl for intravenous postoperative analgesia in elderly patients].
Topics: Aged; Analgesics, Opioid; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Fenta | 2006 |
Improved postoperative analgesia with coadministration of preoperative epidural ketamine and midazolam.
Topics: Adult; Analgesia; Analgesia, Epidural; Analgesics; Analgesics, Opioid; Analysis of Variance; Anesthe | 2006 |
Effect of oral ketamine on the postoperative pain and analgesic requirement following orthopedic surgery.
Topics: Administration, Oral; Adult; Analgesics; Female; Humans; Ketamine; Male; Middle Aged; Orthopedic Pro | 2006 |
The efficacy of intravenous or peritonsillar infiltration of ketamine for postoperative pain relief in children following adenotonsillectomy.
Topics: Adenoidectomy; Anesthetics, Dissociative; Child; Child, Preschool; Female; Humans; Ketamine; Male; P | 2007 |
Ketamine in post-tonsillectomy pain.
Topics: Analgesics; Child; Child, Preschool; Demography; Female; Humans; Ketamine; Male; Pain, Postoperative | 2007 |
The addition of a small-dose ketamine infusion to tramadol for postoperative analgesia: a double-blinded, placebo-controlled, randomized trial after abdominal surgery.
Topics: Abdomen; Adult; Aged; Aged, 80 and over; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opio | 2007 |
Pain prevention with intraoperative ketamine in outpatient children undergoing tonsillectomy or tonsillectomy and adenotomy.
Topics: Adenoidectomy; Adolescent; Ambulatory Surgical Procedures; Analgesics; Analgesics, Opioid; Anesthesi | 2007 |
Intraoperative small-dose ketamine does not reduce pain or analgesic consumption during perioperative opioid analgesia in children after tonsillectomy.
Topics: Adolescent; Analgesics; Anesthetics, Dissociative; Child; Double-Blind Method; Female; Humans; Intra | 2007 |
The use of ketamine as rescue analgesia in the recovery room following morphine administration--a double-blind randomised controlled trial in postoperative patients.
Topics: Analgesia; Analgesics; Analgesics, Opioid; Double-Blind Method; Female; Humans; Ketamine; Male; Midd | 2007 |
Adding ketamine to morphine for patient-controlled analgesia after thoracic surgery: influence on morphine consumption, respiratory function, and nocturnal desaturation.
Topics: Adult; Aged; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Anesthesia, General; Cir | 2007 |
Adding ketamine to morphine for patient-controlled analgesia after thoracic surgery: influence on morphine consumption, respiratory function, and nocturnal desaturation.
Topics: Adult; Aged; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Anesthesia, General; Cir | 2007 |
Adding ketamine to morphine for patient-controlled analgesia after thoracic surgery: influence on morphine consumption, respiratory function, and nocturnal desaturation.
Topics: Adult; Aged; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Anesthesia, General; Cir | 2007 |
Adding ketamine to morphine for patient-controlled analgesia after thoracic surgery: influence on morphine consumption, respiratory function, and nocturnal desaturation.
Topics: Adult; Aged; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Anesthesia, General; Cir | 2007 |
A randomised double blind trial of the effect of pre-emptive epidural ketamine on persistent pain after lower limb amputation.
Topics: Aged; Amputation, Surgical; Analgesia, Epidural; Analgesics; Analysis of Variance; Double-Blind Meth | 2008 |
Comparison of a preincisional and postincisional small dose of ketamine for postoperative analgesia in children.
Topics: Adolescent; Anesthetics, Dissociative; Child; Child, Preschool; Double-Blind Method; Female; Humans; | 2007 |
Bowel function after bowel surgery: morphine with ketamine or placebo; a randomized controlled trial pilot study.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, Dissociative; Digestive Syste | 2007 |
Effects of postoperative ketamine infusion on pain control and feeding behaviour in bitches undergoing mastectomy.
Topics: Anesthetics, Dissociative; Animals; Dog Diseases; Dogs; Feeding Behavior; Female; Infusions, Intrave | 2007 |
[Intra-articular ketamine after arthroscopic knee surgery. Optimisation of postoperative analgesia].
Topics: Adolescent; Adult; Aged; Analgesics, Opioid; Anesthetics, Dissociative; Anesthetics, Local; Arthrosc | 2007 |
Combination of low doses of intrathecal ketamine and midazolam with bupivacaine improves postoperative analgesia in orthopaedic surgery.
Topics: Adjuvants, Anesthesia; Adult; Analgesics; Anesthesia, Spinal; Anesthetics, Local; Bupivacaine; Doubl | 2008 |
Effect of a low-dose ketamine regimen on pain, mood, cognitive function and memory after major gynaecological surgery: a randomized, double-blind, placebo-controlled trial.
Topics: Adolescent; Adult; Affect; Aged; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Anti | 2008 |
[Diprivan versus midazolam in combined anaesthesia with ketamin for minor gynecological surgery].
Topics: Abortion, Induced; Adult; Anesthesia; Anesthetics, Intravenous; Drug Administration Schedule; Drug T | 2007 |
Pre-incisional epidural ropivacaine, sufentanil, clonidine, and (S)+-ketamine does not provide pre-emptive analgesia in patients undergoing major pancreatic surgery.
Topics: Adult; Aged; Amides; Analgesia, Epidural; Analgesia, Patient-Controlled; Clonidine; Double-Blind Met | 2008 |
Is the combination of morphine with ketamine better than morphine alone for postoperative intravenous patient-controlled analgesia?
Topics: Adult; Aged; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Double-Blind Method; Dru | 2008 |
Topical ketamine and morphine for post-tonsillectomy pain.
Topics: Analgesics; Analgesics, Opioid; Child; Child, Preschool; Drug Therapy, Combination; Female; Humans; | 2008 |
[Administration of ketamine during induction and maintenance of anaesthesia in postoperative pain prevention].
Topics: Adult; Aged; Analgesics; Anesthesia; Breast Neoplasms; Double-Blind Method; Female; Humans; Ketamine | 2008 |
The preventative analgesic effect of preincisional peritonsillar infiltration of two low doses of ketamine for postoperative pain relief in children following adenotonsillectomy. A randomized, double-blind, placebo-controlled study.
Topics: Adenoidectomy; Analgesics; Anesthesia, Local; Child; Child, Preschool; Dose-Response Relationship, D | 2008 |
No morphine sparing effect of ketamine added to morphine for patient-controlled intravenous analgesia after uterine artery embolization.
Topics: Adult; Analgesia; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Drug Therapy, Combi | 2008 |
Analgesic effectiveness of caudal levobupivacaine and ketamine.
Topics: Abdomen; Analgesics; Anesthesia, Caudal; Anesthetics, Combined; Anesthetics, Dissociative; Anestheti | 2008 |
Comparison of caudal epidural bupivacaine with bupivacaine plus tramadol and bupivacaine plus ketamine for postoperative analgesia in children.
Topics: Acetaminophen; Analgesia, Epidural; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthetics, Disso | 2008 |
[Three subanaesthetic dose ketamines mixed with butorphanol in the postoperative continuous intravenous analgesia].
Topics: Adult; Analgesia; Analgesics; Butorphanol; Dose-Response Relationship, Drug; Drug Therapy, Combinati | 2008 |
Subanaesthetic ketamine spares postoperative morphine and controls pain better than standard morphine does alone in orthopaedic-oncological patients.
Topics: Adolescent; Adult; Aged; Analgesics; Analysis of Variance; Bone Neoplasms; Double-Blind Method; Drug | 2008 |
Ketamine does not reduce postoperative morphine consumption after tonsillectomy in children.
Topics: Analgesics; Child; Child, Preschool; Dose-Response Relationship, Drug; Double-Blind Method; Drug Adm | 2008 |
Postoperative ketamine administration decreases morphine consumption in major abdominal surgery: a prospective, randomized, double-blind, controlled study.
Topics: Abdomen; Aged; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Double-Blind Method; D | 2008 |
Postoperative ketamine administration decreases morphine consumption in major abdominal surgery: a prospective, randomized, double-blind, controlled study.
Topics: Abdomen; Aged; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Double-Blind Method; D | 2008 |
Postoperative ketamine administration decreases morphine consumption in major abdominal surgery: a prospective, randomized, double-blind, controlled study.
Topics: Abdomen; Aged; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Double-Blind Method; D | 2008 |
Postoperative ketamine administration decreases morphine consumption in major abdominal surgery: a prospective, randomized, double-blind, controlled study.
Topics: Abdomen; Aged; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Double-Blind Method; D | 2008 |
[Clinical experimental studies of postoperative infusion analgesia].
Topics: Adult; Analgesics; Carbon Dioxide; Female; Humans; Hysterectomy; Ketamine; Middle Aged; Pain, Postop | 1983 |
Clinical experimental studies of postoperative infusion analgesia.
Topics: Adult; Analgesics; Female; Humans; Hysterectomy; Infusions, Parenteral; Ketamine; Middle Aged; Pain, | 1983 |
Ketamine fro postoperative analgesia after upper abdominal surgery.
Topics: Abdomen; Adult; Aged; Analgesia; Blood Pressure; Carbon Dioxide; Cholecystectomy; Clinical Trials as | 1981 |
[Use of ketamine combined with local anesthetics in epidural anesthesia].
Topics: Adult; Aged; Anesthesia, Epidural; Bupivacaine; Female; Humans; Ketamine; Male; Middle Aged; Pain, P | 1995 |
Subcutaneous infusion of ketamine and morphine for relief of postoperative pain: a double-blind comparative study.
Topics: Abdomen; Adult; Awareness; Double-Blind Method; Female; Humans; Infusion Pumps; Injections, Subcutan | 1994 |
Postoperative pain: the effect of low-dose ketamine in addition to general anesthesia.
Topics: Adult; Aged; Anesthesia, General; Cholecystectomy; Double-Blind Method; Elective Surgical Procedures | 1993 |
Patient evaluation of four different combinations of intravenous anaesthetics for short outpatient procedures.
Topics: Abortion, Induced; Adolescent; Adult; Ambulatory Surgical Procedures; Anesthesia, General; Anesthesi | 1993 |
Preemptive effect of fentanyl and ketamine on postoperative pain and wound hyperalgesia.
Topics: Adult; Analgesia; Double-Blind Method; Female; Fentanyl; Humans; Hyperalgesia; Ketamine; Middle Aged | 1994 |
Combined infusions of morphine and ketamine for postoperative pain in elderly patients.
Topics: Abdomen; Aged; Analgesia, Patient-Controlled; Double-Blind Method; Dreams; Drug Therapy, Combination | 1993 |
Comparison of the effects of adrenaline, clonidine and ketamine on the duration of caudal analgesia produced by bupivacaine in children.
Topics: Analgesia; Anesthetics, Dissociative; Anesthetics, Local; Bupivacaine; Child; Child, Preschool; Clon | 1995 |
Comparison of morphine and morphine with ketamine for postoperative analgesia.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Diskectomy; Double-Blind Metho | 1996 |
Comparison of morphine and morphine with ketamine for postoperative analgesia.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Diskectomy; Double-Blind Metho | 1996 |
Comparison of morphine and morphine with ketamine for postoperative analgesia.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Diskectomy; Double-Blind Metho | 1996 |
Comparison of morphine and morphine with ketamine for postoperative analgesia.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Diskectomy; Double-Blind Metho | 1996 |
Comparison of morphine and morphine with ketamine for postoperative analgesia.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Diskectomy; Double-Blind Metho | 1996 |
Comparison of morphine and morphine with ketamine for postoperative analgesia.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Diskectomy; Double-Blind Metho | 1996 |
Comparison of morphine and morphine with ketamine for postoperative analgesia.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Diskectomy; Double-Blind Metho | 1996 |
Comparison of morphine and morphine with ketamine for postoperative analgesia.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Diskectomy; Double-Blind Metho | 1996 |
Comparison of morphine and morphine with ketamine for postoperative analgesia.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Diskectomy; Double-Blind Metho | 1996 |
Comparison of morphine and morphine with ketamine for postoperative analgesia.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Diskectomy; Double-Blind Metho | 1996 |
Comparison of morphine and morphine with ketamine for postoperative analgesia.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Diskectomy; Double-Blind Metho | 1996 |
Comparison of morphine and morphine with ketamine for postoperative analgesia.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Diskectomy; Double-Blind Metho | 1996 |
Comparison of morphine and morphine with ketamine for postoperative analgesia.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Diskectomy; Double-Blind Metho | 1996 |
Comparison of morphine and morphine with ketamine for postoperative analgesia.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Diskectomy; Double-Blind Metho | 1996 |
Comparison of morphine and morphine with ketamine for postoperative analgesia.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Diskectomy; Double-Blind Metho | 1996 |
Comparison of morphine and morphine with ketamine for postoperative analgesia.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Diskectomy; Double-Blind Metho | 1996 |
Comparison of morphine and morphine with ketamine for postoperative analgesia.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Diskectomy; Double-Blind Metho | 1996 |
Comparison of morphine and morphine with ketamine for postoperative analgesia.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Diskectomy; Double-Blind Metho | 1996 |
Comparison of morphine and morphine with ketamine for postoperative analgesia.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Diskectomy; Double-Blind Metho | 1996 |
Comparison of morphine and morphine with ketamine for postoperative analgesia.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Diskectomy; Double-Blind Metho | 1996 |
Comparison of morphine and morphine with ketamine for postoperative analgesia.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Diskectomy; Double-Blind Metho | 1996 |
Comparison of morphine and morphine with ketamine for postoperative analgesia.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Diskectomy; Double-Blind Metho | 1996 |
Comparison of morphine and morphine with ketamine for postoperative analgesia.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Diskectomy; Double-Blind Metho | 1996 |
Comparison of morphine and morphine with ketamine for postoperative analgesia.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Diskectomy; Double-Blind Metho | 1996 |
Comparison of morphine and morphine with ketamine for postoperative analgesia.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Diskectomy; Double-Blind Metho | 1996 |
The optimal dose of ketamine for caudal epidural blockade in children.
Topics: Anesthesia, Caudal; Anesthetics, Combined; Anesthetics, Dissociative; Anesthetics, Local; Bupivacain | 1996 |
Preemptive ketamine decreases postoperative narcotic requirements in patients undergoing abdominal surgery.
Topics: Abdomen; Analgesia, Patient-Controlled; Double-Blind Method; Excitatory Amino Acid Agonists; Female; | 1997 |
Preemptive ketamine decreases postoperative narcotic requirements in patients undergoing abdominal surgery.
Topics: Abdomen; Analgesia, Patient-Controlled; Double-Blind Method; Excitatory Amino Acid Agonists; Female; | 1997 |
Preemptive ketamine decreases postoperative narcotic requirements in patients undergoing abdominal surgery.
Topics: Abdomen; Analgesia, Patient-Controlled; Double-Blind Method; Excitatory Amino Acid Agonists; Female; | 1997 |
Preemptive ketamine decreases postoperative narcotic requirements in patients undergoing abdominal surgery.
Topics: Abdomen; Analgesia, Patient-Controlled; Double-Blind Method; Excitatory Amino Acid Agonists; Female; | 1997 |
A new method to evaluate central sensitization to pain following surgery. Effect of ketamine.
Topics: Action Potentials; Analgesics, Opioid; Anesthesia, Intravenous; Anesthetics, Dissociative; Dermatolo | 1997 |
Mapping of punctuate hyperalgesia around a surgical incision demonstrates that ketamine is a powerful suppressor of central sensitization to pain following surgery.
Topics: Adult; Aged; Anesthesia; Anesthetics, Dissociative; Double-Blind Method; Female; Humans; Hyperalgesi | 1997 |
Mapping of punctuate hyperalgesia around a surgical incision demonstrates that ketamine is a powerful suppressor of central sensitization to pain following surgery.
Topics: Adult; Aged; Anesthesia; Anesthetics, Dissociative; Double-Blind Method; Female; Humans; Hyperalgesi | 1997 |
Mapping of punctuate hyperalgesia around a surgical incision demonstrates that ketamine is a powerful suppressor of central sensitization to pain following surgery.
Topics: Adult; Aged; Anesthesia; Anesthetics, Dissociative; Double-Blind Method; Female; Humans; Hyperalgesi | 1997 |
Mapping of punctuate hyperalgesia around a surgical incision demonstrates that ketamine is a powerful suppressor of central sensitization to pain following surgery.
Topics: Adult; Aged; Anesthesia; Anesthetics, Dissociative; Double-Blind Method; Female; Humans; Hyperalgesi | 1997 |
Postoperative analgesic requirement after cesarean section: a comparison of anesthetic induction with ketamine or thiopental.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthesia, Obstetrical; Anesthetics, Diss | 1997 |
Comparison of caudal block using bupivacaine and ketamine with ilioinguinal nerve block for orchidopexy in children.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anesthesia, Caudal; Anesthesia, General; Anesthetics, Combi | 1997 |
Desflurane versus propofol maintenance for outpatient laparoscopic cholecystectomy.
Topics: Ambulatory Surgical Procedures; Analgesics, Non-Narcotic; Anesthesia Recovery Period; Anesthetics, D | 1998 |
Adding ketamine in a multimodal patient-controlled epidural regimen reduces postoperative pain and analgesic consumption.
Topics: Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, Dissociative; A | 1998 |
Double-blind comparison of extradural block with three bupivacaine-ketamine mixtures in knee arthroplasty.
Topics: Aged; Aged, 80 and over; Analgesia, Epidural; Anesthesia, Epidural; Anesthetics, Combined; Anestheti | 1998 |
Preoperative epidural ketamine does not have a postoperative opioid sparing effect.
Topics: Abdomen; Adult; Analgesics, Opioid; Anesthetics, Dissociative; Female; Humans; Injections, Epidural; | 1998 |
No inhibition of gastro-intestinal propulsion after propofol- or propofol/ketamine-N2O/O2 anaesthesia. A comparison of gastro-caecal transit after isoflurane anaesthesia.
Topics: Adult; Anesthetics, Combined; Anesthetics, Dissociative; Anesthetics, Inhalation; Anesthetics, Intra | 1998 |
Lack of pre-emptive analgesic effect of (R)-ketamine in laparoscopic cholecystectomy.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthesia, General; Anesthetics, Dissocia | 1999 |
[Continuous total intravenous anesthesia is useful for postoperative pain management].
Topics: Abdominal Pain; Analgesics; Anesthesia, Epidural; Anesthesia, Inhalation; Anesthesia, Intravenous; A | 1999 |
Effect of i.v. ketamine in combination with epidural bupivacaine or epidural morphine on postoperative pain and wound tenderness after renal surgery.
Topics: Adult; Aged; Analgesia, Epidural; Analgesics; Analgesics, Opioid; Anesthetics, Local; Bupivacaine; D | 1998 |
Small-dose ketamine enhances morphine-induced analgesia after outpatient surgery.
Topics: Adult; Aged; Ambulatory Surgical Procedures; Analgesia; Analgesics, Opioid; Double-Blind Method; Dru | 1999 |
Preoperative small-dose ketamine has no preemptive analgesic effect in patients undergoing total mastectomy.
Topics: Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Double-Blind Method; Female; Humans; | 1999 |
[Preemptive effects caused by co-analgesia with ketamine in gynecological laparotomies?].
Topics: Analgesics; Anesthesia, General; Dose-Response Relationship, Drug; Double-Blind Method; Drug Adminis | 1999 |
The benefits of intraoperative small-dose ketamine on postoperative pain after anterior cruciate ligament repair.
Topics: Adolescent; Adult; Aged; Analgesics, Opioid; Anesthesia, General; Anesthetics, Dissociative; Anterio | 2000 |
The benefits of intraoperative small-dose ketamine on postoperative pain after anterior cruciate ligament repair.
Topics: Adolescent; Adult; Aged; Analgesics, Opioid; Anesthesia, General; Anesthetics, Dissociative; Anterio | 2000 |
The benefits of intraoperative small-dose ketamine on postoperative pain after anterior cruciate ligament repair.
Topics: Adolescent; Adult; Aged; Analgesics, Opioid; Anesthesia, General; Anesthetics, Dissociative; Anterio | 2000 |
The benefits of intraoperative small-dose ketamine on postoperative pain after anterior cruciate ligament repair.
Topics: Adolescent; Adult; Aged; Analgesics, Opioid; Anesthesia, General; Anesthetics, Dissociative; Anterio | 2000 |
Postoperative analgesia with i.v. patient-controlled morphine: effect of adding ketamine.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesia, Patient-Controlled; Analgesics; Analgesics, O | 1999 |
[Pre-incisional administration of ketamine reduced the postoperative pain].
Topics: Analgesics; Analgesics, Opioid; Anesthesia, Epidural; Anesthesia, Spinal; Anesthetics, Local; Bupiva | 1999 |
Pre-incisional epidural ketamine, morphine and bupivacaine combined with epidural and general anaesthesia provides pre-emptive analgesia for upper abdominal surgery.
Topics: Abdomen; Analgesics; Anesthesia, Epidural; Anesthesia, General; Anesthetics, Local; Bupivacaine; Dru | 2000 |
The effect of ketamine on 0.25% and 0.125% bupivacaine for caudal epidural blockade in children.
Topics: Acetaminophen; Analgesia, Epidural; Analgesics; Analgesics, Non-Narcotic; Anesthesia Recovery Period | 1999 |
Patient-controlled epidural analgesia with morphine or morphine plus ketamine for post-operative pain relief.
Topics: Abdomen; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Arousal | 1999 |
S(+)-ketamine for caudal block in paediatric anaesthesia.
Topics: Anesthesia, Caudal; Anesthetics, Dissociative; Anesthetics, Local; Bupivacaine; Child; Child, Presch | 2000 |
Does ketamine have preemptive effects in women undergoing abdominal hysterectomy procedures?
Topics: Adult; Anesthetics, Dissociative; Blood Loss, Surgical; Double-Blind Method; Female; Humans; Hystere | 2000 |
Preemptive analgesia by intravenous low-dose ketamine and epidural morphine in gastrectomy: a randomized double-blind study.
Topics: Aged; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics, Opioid; Double-Blind Method; D | 2000 |
Preemptive analgesia by intravenous low-dose ketamine and epidural morphine in gastrectomy: a randomized double-blind study.
Topics: Aged; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics, Opioid; Double-Blind Method; D | 2000 |
Preemptive analgesia by intravenous low-dose ketamine and epidural morphine in gastrectomy: a randomized double-blind study.
Topics: Aged; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics, Opioid; Double-Blind Method; D | 2000 |
Preemptive analgesia by intravenous low-dose ketamine and epidural morphine in gastrectomy: a randomized double-blind study.
Topics: Aged; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics, Opioid; Double-Blind Method; D | 2000 |
Preemptive analgesia by intravenous low-dose ketamine and epidural morphine in gastrectomy: a randomized double-blind study.
Topics: Aged; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics, Opioid; Double-Blind Method; D | 2000 |
Preemptive analgesia by intravenous low-dose ketamine and epidural morphine in gastrectomy: a randomized double-blind study.
Topics: Aged; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics, Opioid; Double-Blind Method; D | 2000 |
Preemptive analgesia by intravenous low-dose ketamine and epidural morphine in gastrectomy: a randomized double-blind study.
Topics: Aged; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics, Opioid; Double-Blind Method; D | 2000 |
Preemptive analgesia by intravenous low-dose ketamine and epidural morphine in gastrectomy: a randomized double-blind study.
Topics: Aged; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics, Opioid; Double-Blind Method; D | 2000 |
Preemptive analgesia by intravenous low-dose ketamine and epidural morphine in gastrectomy: a randomized double-blind study.
Topics: Aged; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics, Opioid; Double-Blind Method; D | 2000 |
Ketamine and oxycodone in the management of postoperative pain.
Topics: Adult; Analgesics; Humans; Ketamine; Male; Oxycodone; Pain, Postoperative; Regression Analysis; Tons | 2000 |
Comparison of ketamine and morphine for analgesia after tonsillectomy in children.
Topics: Adolescent; Analgesics; Analgesics, Opioid; Anesthesia, General; Child; Double-Blind Method; Female; | 2000 |
Comparison of ketamine and morphine for analgesia after tonsillectomy in children.
Topics: Adolescent; Analgesics; Analgesics, Opioid; Anesthesia, General; Child; Double-Blind Method; Female; | 2000 |
Comparison of ketamine and morphine for analgesia after tonsillectomy in children.
Topics: Adolescent; Analgesics; Analgesics, Opioid; Anesthesia, General; Child; Double-Blind Method; Female; | 2000 |
Comparison of ketamine and morphine for analgesia after tonsillectomy in children.
Topics: Adolescent; Analgesics; Analgesics, Opioid; Anesthesia, General; Child; Double-Blind Method; Female; | 2000 |
Comparison of ketamine and morphine for analgesia after tonsillectomy in children.
Topics: Adolescent; Analgesics; Analgesics, Opioid; Anesthesia, General; Child; Double-Blind Method; Female; | 2000 |
Comparison of ketamine and morphine for analgesia after tonsillectomy in children.
Topics: Adolescent; Analgesics; Analgesics, Opioid; Anesthesia, General; Child; Double-Blind Method; Female; | 2000 |
Comparison of ketamine and morphine for analgesia after tonsillectomy in children.
Topics: Adolescent; Analgesics; Analgesics, Opioid; Anesthesia, General; Child; Double-Blind Method; Female; | 2000 |
Comparison of ketamine and morphine for analgesia after tonsillectomy in children.
Topics: Adolescent; Analgesics; Analgesics, Opioid; Anesthesia, General; Child; Double-Blind Method; Female; | 2000 |
Comparison of ketamine and morphine for analgesia after tonsillectomy in children.
Topics: Adolescent; Analgesics; Analgesics, Opioid; Anesthesia, General; Child; Double-Blind Method; Female; | 2000 |
Caudal ropivacaine and ketamine for postoperative analgesia in children.
Topics: Amides; Analgesics; Anesthesia, Caudal; Anesthetics, Local; Child; Child, Preschool; Double-Blind Me | 2000 |
Caudal ropivacaine and ketamine for postoperative analgesia in children.
Topics: Amides; Analgesics; Anesthesia, Caudal; Anesthetics, Local; Child; Child, Preschool; Double-Blind Me | 2000 |
Caudal ropivacaine and ketamine for postoperative analgesia in children.
Topics: Amides; Analgesics; Anesthesia, Caudal; Anesthetics, Local; Child; Child, Preschool; Double-Blind Me | 2000 |
Caudal ropivacaine and ketamine for postoperative analgesia in children.
Topics: Amides; Analgesics; Anesthesia, Caudal; Anesthetics, Local; Child; Child, Preschool; Double-Blind Me | 2000 |
Effects of intrathecal ketamine added to bupivacaine for spinal anaesthesia.
Topics: Adult; Aged; Anesthesia, Spinal; Anesthetics, Combined; Anesthetics, Dissociative; Anesthetics, Loca | 2000 |
Analgesic effects of caudal and intramuscular S(+)-ketamine in children.
Topics: Absorption; Analgesia; Analgesia, Epidural; Analgesics; Blood Pressure; Child; Child, Preschool; Dou | 2000 |
[Pre-emptive analgesia with intravenous ketamine reduces postoperative pain in young patients after appendicectomy: a randomized control study].
Topics: Adolescent; Analgesics; Anesthesia, General; Anti-Inflammatory Agents, Non-Steroidal; Appendectomy; | 2000 |
Transdermal ketamine as an adjuvant for postoperative analgesia after abdominal gynecological surgery using lidocaine epidural blockade.
Topics: Administration, Cutaneous; Adult; Analgesia, Epidural; Anesthetics, Local; Blood Pressure; Excitator | 2000 |
Intra-articular ketamine for pain control following arthroscopic knee surgery.
Topics: Adult; Anesthetics, Dissociative; Female; Humans; Injections, Intra-Articular; Ketamine; Knee; Male; | 2000 |
Comparison of postoperative analgesic effects of preemptively used epidural ketamine and neostigmine.
Topics: Adult; Aged; Analgesia, Epidural; Female; Humans; Ketamine; Male; Middle Aged; Neostigmine; Pain, Po | 2000 |
Small-dose S(+)-ketamine reduces postoperative pain when applied with ropivacaine in epidural anesthesia for total knee arthroplasty.
Topics: Aged; Amides; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics; Anesthesia, Epidural; | 2001 |
A prospective randomized controlled study of the efficacy of ketamine for postoperative pain relief in children after adenotonsillectomy.
Topics: Adenoidectomy; Adolescent; Analgesics, Opioid; Child; Child, Preschool; Excitatory Amino Acid Antago | 2001 |
The effects of small-dose ketamine on propofol sedation: respiration, postoperative mood, perception, cognition, and pain.
Topics: Adult; Affect; Ambulatory Surgical Procedures; Anesthesia, General; Anesthetics, Combined; Anestheti | 2001 |
'Balanced analgesia' in the perioperative period: is there a place for ketamine?
Topics: Aged; Analgesia; Analgesics; Analysis of Variance; Female; Humans; Hyperalgesia; Ketamine; Male; Mid | 2001 |
Adding ketamine to morphine for patient-controlled analgesia after major abdominal surgery: a double-blinded, randomized controlled trial.
Topics: Abdomen; Adult; Analgesics, Opioid; Anesthetics, Dissociative; Double-Blind Method; Drug Therapy, Co | 2001 |
Preincisional intravenous low-dose ketamine and local infiltration with ropivacaine reduces postoperative pain after laparoscopic cholecystectomy.
Topics: Adult; Amides; Analgesics; Anesthetics, Local; Cholecystectomy, Laparoscopic; Cholelithiasis; Dose-R | 2001 |
Evaluation of the safety and efficacy of epidural ketamine combined with morphine for postoperative analgesia after major upper abdominal surgery.
Topics: Abdomen; Adult; Analgesia, Epidural; Analgesics, Opioid; Anesthetics, Dissociative; Double-Blind Met | 2001 |
Intraoperative small-dose ketamine enhances analgesia after outpatient knee arthroscopy.
Topics: Adolescent; Adult; Ambulatory Surgical Procedures; Analgesics, Opioid; Anesthesia, Inhalation; Anest | 2001 |
Preoperative epidural ketamine in combination with morphine does not have a clinically relevant intra- and postoperative opioid-sparing effect.
Topics: Abdomen; Adult; Analgesia, Epidural; Analgesics; Analgesics, Opioid; Anesthesia, General; Double-Bli | 2001 |
How to prolong postoperative analgesia after caudal anaesthesia with ropivacaine in children: S-ketamine versus clonidine.
Topics: Adrenergic alpha-Agonists; Amides; Analgesia, Epidural; Anesthesia Recovery Period; Anesthetics, Dis | 2001 |
The effect of transdermal nitroglycerin on spinal S(+)-ketamine antinociception following orthopedic surgery.
Topics: Adjuvants, Anesthesia; Administration, Cutaneous; Adult; Analgesia, Epidural; Analgesics; Anesthesia | 2001 |
[Lack of pre-emptive analgesic effect of low-dose ketamine in postoperative patients. A prospective, randomised double-blind study].
Topics: Adult; Analgesia, Patient-Controlled; Dose-Response Relationship, Drug; Double-Blind Method; Female; | 2001 |
Perioperative small-dose S(+)-ketamine has no incremental beneficial effects on postoperative pain when standard-practice opioid infusions are used.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Anterior Cruciate Ligament; Ar | 2002 |
Effect of the addition of ketamine to morphine in patient-controlled analgesia.
Topics: Adult; Analgesia, Patient-Controlled; Anesthetics, Combined; Double-Blind Method; Female; Humans; Hy | 2002 |
Supplementing desflurane-remifentanil anesthesia with small-dose ketamine reduces perioperative opioid analgesic requirements.
Topics: Adjuvants, Anesthesia; Aged; Analgesics, Opioid; Anesthetics, Dissociative; Anesthetics, Inhalation; | 2002 |
Small-dose ketamine improves the postoperative state of depressed patients.
Topics: Adult; Anesthesia, General; Anesthetics, Dissociative; Blood Loss, Surgical; Depressive Disorder; Fe | 2002 |
Small-dose ketamine improves the postoperative state of depressed patients.
Topics: Adult; Anesthesia, General; Anesthetics, Dissociative; Blood Loss, Surgical; Depressive Disorder; Fe | 2002 |
Small-dose ketamine improves the postoperative state of depressed patients.
Topics: Adult; Anesthesia, General; Anesthetics, Dissociative; Blood Loss, Surgical; Depressive Disorder; Fe | 2002 |
Small-dose ketamine improves the postoperative state of depressed patients.
Topics: Adult; Anesthesia, General; Anesthetics, Dissociative; Blood Loss, Surgical; Depressive Disorder; Fe | 2002 |
Small-dose ketamine improves the postoperative state of depressed patients.
Topics: Adult; Anesthesia, General; Anesthetics, Dissociative; Blood Loss, Surgical; Depressive Disorder; Fe | 2002 |
Small-dose ketamine improves the postoperative state of depressed patients.
Topics: Adult; Anesthesia, General; Anesthetics, Dissociative; Blood Loss, Surgical; Depressive Disorder; Fe | 2002 |
Small-dose ketamine improves the postoperative state of depressed patients.
Topics: Adult; Anesthesia, General; Anesthetics, Dissociative; Blood Loss, Surgical; Depressive Disorder; Fe | 2002 |
Small-dose ketamine improves the postoperative state of depressed patients.
Topics: Adult; Anesthesia, General; Anesthetics, Dissociative; Blood Loss, Surgical; Depressive Disorder; Fe | 2002 |
Small-dose ketamine improves the postoperative state of depressed patients.
Topics: Adult; Anesthesia, General; Anesthetics, Dissociative; Blood Loss, Surgical; Depressive Disorder; Fe | 2002 |
Postoperative analgesia with ketamine and pethidine.
Topics: Adult; Aged; Clinical Trials as Topic; Drug Therapy, Combination; Female; Humans; Ketamine; Male; Me | 1977 |
Comparison of thiopentone, Althesin and ketamine in anaesthesia for otolaryngological surgery in children.
Topics: Alfaxalone Alfadolone Mixture; Anesthesia, General; Blood Pressure; Child; Child, Preschool; Female; | 1977 |
Intravenous ketamine for postoperative analgesia.
Topics: Clinical Trials as Topic; Humans; Infusions, Parenteral; Ketamine; Morphine; Pain, Postoperative; Pl | 1975 |
Intramuscular low-dose ketamine versus pethidine for postoperative pain treatment after thoracic surgery.
Topics: Adult; Aged; Double-Blind Method; Hemodynamics; Humans; Injections, Intramuscular; Ketamine; Meperid | 1992 |
Ketamine for caudal analgesia in children: comparison with caudal bupivacaine.
Topics: Analgesia, Epidural; Bupivacaine; Cauda Equina; Child; Child Behavior; Child, Preschool; Double-Blin | 1991 |
[Anesthesia in patients with varicose syndrome].
Topics: Anesthesia; Halothane; Humans; Ketamine; Nitrous Oxide; Pain, Postoperative; Varicose Veins | 1989 |
A double-blind comparison of epidural ketamine and diamorphine for postoperative analgesia.
Topics: Adult; Aged; Analgesia, Epidural; Clinical Trials as Topic; Double-Blind Method; Female; Heroin; Hum | 1989 |
Comparison of ketamine and pethidine in experimental and postoperative pain.
Topics: Adult; Female; Humans; Ischemia; Ketamine; Meperidine; Naloxone; Pain; Pain, Postoperative; Visual P | 1989 |
Subcutaneous ketamine analgesia: postoperative analgesia using subcutaneous infusions of ketamine and morphine.
Topics: Adult; Drug Therapy, Combination; Female; Humans; Hysterectomy; Infusions, Parenteral; Injections, I | 1989 |
[Lack of depression of ventilatory responses to CO2 following epidural or intravenous infusion of ketamine in postoperative analgesia after upper abdominal surgery].
Topics: Adult; Aged; Analgesia, Epidural; Anesthesia, Intravenous; Cholecystectomy; Clinical Trials as Topic | 1988 |
Epidural ketamine or morphine for postoperative analgesia.
Topics: Clinical Trials as Topic; Humans; Injections, Epidural; Ketamine; Morphine; Pain, Postoperative; Ran | 1987 |
Epidural ketamine for postoperative pain relief after gynecologic operations: a double-blind study and comparison with epidural morphine.
Topics: Adult; Aged; Clinical Trials as Topic; Double-Blind Method; Female; Genital Diseases, Female; Humans | 1987 |
Analgesia from morphine and ketamine. A comparison of infusions of morphine and ketamine for postoperative analgesia.
Topics: Clinical Trials as Topic; Double-Blind Method; Female; Hemodynamics; Humans; Infusions, Intravenous; | 1987 |
Prevention of post-tonsillectomy pain with analgesic doses of ketamine.
Topics: Child; Child, Preschool; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Ketamine; Ma | 1987 |
Low-dose ketamine infusion for analgesia during postoperative ventilator treatment.
Topics: Aged; Anesthesia; Body Temperature; Female; Humans; Infusions, Intravenous; Intubation, Intratrachea | 1986 |
199 other studies available for ketamine and Pain, Postoperative
| Article | Year |
|---|---|
Comment on "Perioperative intravenous S-ketamine for acute postoperative pain in adults: A systematic review and meta-analysis".
Topics: Adult; Humans; Ketamine; Pain, Postoperative | 2021 |
Intraoperative Dexmedetomidine and Ketamine Infusions in an Enhanced Recovery After Thoracic Surgery Program: A Propensity Score Matched Analysis.
Topics: Analgesics, Opioid; Dexmedetomidine; Humans; Ketamine; Pain, Postoperative; Propensity Score; Retros | 2022 |
Antinociceptive and analgesic effect of continuous intravenous infusion of maropitant, lidocaine and ketamine alone or in combination in cats undergoing ovariohysterectomy.
Topics: Analgesics; Animals; Cat Diseases; Cats; Female; Infusions, Intravenous; Ketamine; Lidocaine; Ovarie | 2021 |
Intranasal dexmedetomidine and rectal ketamine for young children undergoing burn wound procedures.
Topics: Administration, Intranasal; Burns; Child; Child, Preschool; Dexmedetomidine; Humans; Hypnotics and S | 2022 |
Opioid-free versus opioid-based anesthesia in pancreatic surgery.
Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Anesthesia; Anesthetics, Local; Animals; Anti-In | 2022 |
Effect of low-dose esketamine on pain control and postpartum depression after cesarean section: a retrospective cohort study.
Topics: Cesarean Section; Depression, Postpartum; Female; Humans; Ketamine; Pain, Postoperative; Pregnancy; | 2022 |
Low-dose ketamine infusions reduce opioid use in pediatric and young adult oncology patients.
Topics: Acute Pain; Analgesics; Analgesics, Opioid; Child; Death; Humans; Infusions, Intravenous; Ketamine; | 2022 |
Compatibility of intravenous acetaminophen with morphine, fentanyl and ketamine in acute pediatric pain setting.
Topics: Acetaminophen; Acute Pain; Analgesics, Opioid; Child; Double-Blind Method; Fentanyl; Humans; Ketamin | 2022 |
Ketamine Infusion After Abrupt Cessation of High-Dose Intrathecal Hydromorphone: A Case Report.
Topics: Analgesics, Opioid; Humans; Hydromorphone; Injections, Spinal; Ketamine; Pain, Postoperative | 2023 |
Continuous Intravenous Ketamine for Pain Control After Tibial or Femoral Osteotomy.
Topics: Analgesics, Opioid; Humans; Ketamine; Osteotomy; Pain Management; Pain, Postoperative; Retrospective | 2023 |
A Case Illustrating the Practical Application of the AAOS Clinical Practice Guideline: Pharmacologic, Physical, and Cognitive Pain Alleviation for Musculoskeletal Extremity/Pelvis Surgery.
Topics: Acetaminophen; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Cognition; Cyclooxygenas | 2022 |
Comparing Postoperative Analgesic Efficacy of Adding Ketamine, Dexmedetomidine and Lidocaine to Multimodal Regimen.
Topics: Analgesics; Anesthetics, Local; Dexmedetomidine; Double-Blind Method; Humans; Ketamine; Lidocaine; P | 2022 |
Opioid-sparing anesthesia and patient-reported outcomes after open gynecologic surgery: a historical cohort study.
Topics: Analgesics, Opioid; Anesthesia; Cohort Studies; Dexmedetomidine; Female; Gynecologic Surgical Proced | 2022 |
Multimodal analgesia practices for knee and hip arthroplasties in the Netherlands. A prospective observational study from the PAIN OUT registry.
Topics: Analgesia; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Arthroplasty, Replacement, Hip; Arth | 2022 |
Impact of Perioperative Ketamine on Postoperative Bariatric Surgery Opioid Use and Length of Stay.
Topics: Analgesics, Opioid; Bariatric Surgery; Humans; Ketamine; Length of Stay; Pain, Postoperative; Retros | 2023 |
The Association Between Enhanced Recovery After Cardiac Surgery-Guided Analgesics and Postoperative Delirium.
Topics: Acetaminophen; Adult; Analgesics; Analgesics, Opioid; Cardiac Surgical Procedures; Dexmedetomidine; | 2023 |
A prospective observational study of the efficacy of ketamine for rescue analgesia in the postanesthesia recovery unit.
Topics: Adult; Analgesia; Analgesics; Analgesics, Opioid; Double-Blind Method; Humans; Ketamine; Pain, Posto | 2023 |
Effect of Analgesic Low-Dose Ketamine Infusions on the Cardiovascular Response: A Retrospective Analysis.
Topics: Acute Pain; Adult; Analgesics; Analgesics, Opioid; Humans; Hypertension; Ketamine; Pain, Postoperati | 2023 |
Postmastectomy analgesia with subcutaneous infiltration of ketamine with lidocaine in surgical wound.
Topics: Analgesia; Analgesics; Anesthetics, Local; Breast Neoplasms; Double-Blind Method; Female; Humans; Ke | 2023 |
Ketamine reduces remifentanil-induced postoperative hyperalgesia mediated by CaMKII-NMDAR in the primary somatosensory cerebral cortex region in mice.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2020 |
Cochrane in CORR®: Perioperative Intravenous Ketamine for Acute Postoperative Pain in Adults.
Topics: Administration, Intravenous; Adult; Analgesics; Humans; Ketamine; Pain, Postoperative | 2019 |
Single Dose of Ketamine During Kyphoplasty Procedures Does Not Reduce Postoperative Narcotic Consumption.
Topics: Aged; Analgesics, Opioid; Anesthesia, General; Anesthetics, Dissociative; Cohort Studies; Female; Hu | 2019 |
Commentary on "Ketamine reduces pain and opioid consumption after total knee arthroplasty: A meta-analysis of randomized controlled studies" (Int J Surg 2019;70:70-83).
Topics: Analgesics, Opioid; Arthroplasty, Replacement, Knee; Humans; Ketamine; Pain, Postoperative | 2019 |
Reply letter to: "Commentary on: Ketamine reduces pain and opioid consumption after total knee arthroplasty: A meta-analysis of randomized controlled studies".
Topics: Analgesics, Opioid; Arthroplasty, Replacement, Knee; Humans; Ketamine; Pain, Postoperative | 2019 |
There are probably no added benefits of intravenous ketamine for postoperative pain in patients undergoing third-molar extraction who receive perioperative antibiotics, ibuprofen, and dexamethasone.
Topics: Anti-Bacterial Agents; Dexamethasone; Double-Blind Method; Humans; Ibuprofen; Ketamine; Molar; Molar | 2020 |
Clinically important analgesic effects.
Topics: Analgesics; Anesthetics, Dissociative; Humans; Ketamine; Orthopedic Procedures; Pain, Postoperative | 2020 |
Opioid sparing multimodal analgesia treats pain after head and neck microvascular reconstruction.
Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Combined Modality Therapy; Female; Free Tissue Flaps; G | 2020 |
What Is the Role of Ketamine in Postoperative Pain Management?
Topics: Analgesia; Coronary Artery Bypass; Double-Blind Method; Humans; Ketamine; Pain, Postoperative | 2020 |
Effects of Multimodal Analgesia on Recovery From Percutaneous Spinal Cord Stimulator Implantation.
Topics: Analgesia; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Humans; Ketamine | 2023 |
Analgesic efficacy of an intravenous constant rate infusion of a morphine-lidocaine-ketamine combination in Holstein calves undergoing umbilical herniorrhaphy.
Topics: Analgesics; Animals; Cattle; Female; Hernia, Umbilical; Herniorrhaphy; Hydrocortisone; Infusions, In | 2020 |
Prevention and Prediction of Postsurgical Pain: Reply.
Topics: Cardiac Surgical Procedures; Humans; Ketamine; Pain, Postoperative; Pregabalin | 2020 |
Prevention and Prediction of Postsurgical Pain: Comment.
Topics: Cardiac Surgical Procedures; Humans; Ketamine; Pain, Postoperative; Pregabalin | 2020 |
Ketamine relieves depression-like behaviors induced by chronic postsurgical pain in rats through anti-inflammatory, anti-oxidant effects and regulating BDNF expression.
Topics: Animals; Anti-Inflammatory Agents; Antidepressive Agents; Antioxidants; Brain-Derived Neurotrophic F | 2020 |
Implementation of a perioperative ketamine shortage mitigation strategy.
Topics: Analgesics; Humans; Ketamine; Pain, Postoperative; Perioperative Care; Retrospective Studies | 2020 |
Managing Postoperative Pain: Rethinking Adjuvant Therapies.
Topics: Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Complementary Therapies; Humans; Ketami | 2020 |
Perioperative Multimodal Analgesia Reduces Opioid Use Following Skin Grafting in Nonintubated Burn Patients.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics; Analgesics, Opioid; Bandages; | 2020 |
Intravenous Ketamine Administered as Patient Controlled Analgesia and Continuous Infusion for Central Pain Syndrome.
Topics: Analgesia, Patient-Controlled; Humans; Infusions, Intravenous; Ketamine; Male; Middle Aged; Pain; Pa | 2021 |
Ketamine for post-operative pain treatment in spinal surgery. A protocol for a systematic review with meta-analysis and trial sequential analysis.
Topics: Humans; Ketamine; Meta-Analysis as Topic; Pain, Postoperative; Systematic Reviews as Topic | 2021 |
Ketamine and Advantages for the Postsurgical Patient.
Topics: Humans; Ketamine; Pain, Postoperative | 2020 |
Opioid-free anesthesia with a mixture of dexmedetomidine, ketamine, and lidocaine in one syringe for surgery in obese patients.
Topics: Analgesics, Opioid; Anesthesia; Cesarean Section; Dexmedetomidine; Double-Blind Method; Female; Huma | 2020 |
Subcutaneous ketamine prolongs the analgesic effect of local infiltration of plain Bupivacaine in children undergoing inguinal herniotomy.
Topics: Analgesics, Opioid; Anesthesia Recovery Period; Anesthetics, Dissociative; Anesthetics, Local; Bupiv | 2020 |
Intraoperative Ketamine for the Opioid-Naïve Patients: Move Along Folks, Nothing to See Here?
Topics: Analgesics, Opioid; Double-Blind Method; Humans; Ketamine; Pain, Postoperative | 2021 |
Examining Use of Low-Dose Ketamine Infusions During the Postoperative Period: A Retrospective Study Comparing Opioid-Tolerant and Nonopioid-Tolerant Patients.
Topics: Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Humans; Infusions, Intravenous; Ketamine; | 2021 |
Preanesthetic nebulized ketamine vs preanesthetic oral ketamine for sedation and postoperative pain management in children for elective surgery: A retrospective analysis for effectiveness and safety.
Topics: Analgesics; Antiemetics; Child; Child, Preschool; Elective Surgical Procedures; Female; Humans; Keta | 2021 |
Methadone and Ketamine: Boosting Benefits and Still More to Learn.
Topics: Double-Blind Method; Humans; Ketamine; Methadone; Pain, Postoperative; Spine | 2021 |
Reasons for discontinuation of acute postoperative pain ketamine infusions: A retrospective case-control study.
Topics: Analgesia, Patient-Controlled; Analgesics, Opioid; Case-Control Studies; Humans; Infusions, Intraven | 2021 |
Ketamine and Perioperative Analgesia: A Predictable Outcome?
Topics: Analgesia; Analgesics; Humans; Ketamine; Pain, Postoperative | 2021 |
Low-dose ketamine infusion for post-cesarean delivery analgesia in patients with opioid use disorder.
Topics: Analgesia; Analgesics, Opioid; Cesarean Section; Double-Blind Method; Female; Humans; Ketamine; Opio | 2021 |
Incidence of persistent postoperative pain after hepatectomies with 2 regimes of perioperative analgesia containing ketamine.
Topics: Aged; Analgesics; Female; Hepatectomy; Humans; Hyperalgesia; Incidence; Ketamine; Male; Middle Aged; | 2017 |
Pharmacological advances in the multimodal management of perioperative analgesia.
Topics: Analgesia; Analgesics; Analgesics, Opioid; Clinical Trials as Topic; Combined Modality Therapy; Dexm | 2017 |
Early Onset and Treatment of Phantom Limb Pain Following Surgical Amputation.
Topics: Aged; Amputation, Surgical; Analgesics; Anesthetics, Local; Calcitonin; Early Medical Intervention; | 2017 |
Is intravenous ketamine effective for postoperative pain management in adults?
Topics: Administration, Intravenous; Adult; Analgesics; Databases, Factual; Excitatory Amino Acid Antagonist | 2017 |
Low-dose subcutaneous ketamine for postoperative pain management in Rwanda: a dose-finding study.
Topics: Adult; Analgesics; Dose-Response Relationship, Drug; Female; Humans; Injections, Subcutaneous; Ketam | 2017 |
Ketamine: We need to continue to advocate against scheduling.
Topics: Anesthetics, Dissociative; Humans; Ketamine; Pain Management; Pain, Postoperative | 2017 |
Assessing analgesia equivalence and appetite following alfaxalone- or ketamine-based injectable anesthesia for feline castration as an example of enhanced recovery after surgery.
Topics: Analgesia; Analgesics; Anesthesia; Anesthetics; Animals; Cats; Dexmedetomidine; Feeding Behavior; Hy | 2018 |
Surgical preparation of rats and mice for intravital microscopic imaging of abdominal organs.
Topics: Abdomen; Anesthetics, Dissociative; Animals; Female; Intravital Microscopy; Ketamine; Male; Mice; Pa | 2017 |
[Comment on: ketamine for prevention of postoperative delirium and pain].
Topics: Analgesics; Delirium; Humans; Ketamine; Pain; Pain, Postoperative; Postoperative Complications | 2017 |
Substance abuse in the anesthesia block room by a patient.
Topics: Anesthesia, Intravenous; Elective Surgical Procedures; Humans; Hypnotics and Sedatives; Ketamine; Mi | 2017 |
Oral Ketamine for Acute Pain Management After Amputation Surgery.
Topics: Acute Pain; Administration, Oral; Amputation, Surgical; Analgesics; Female; Humans; Ketamine; Male; | 2018 |
Cost-Effectiveness of Postoperative Ketamine in Chiari Decompression.
Topics: Adult; Analgesics; Arnold-Chiari Malformation; Clinical Protocols; Cost-Benefit Analysis; Female; He | 2018 |
Postoperative pain and study design: the type of surgical procedure matters.
Topics: Humans; Ketamine; Pain Measurement; Pain, Postoperative; Rwanda | 2018 |
Safety in Acute Pain Medicine-Pharmacologic Considerations and the Impact of Systems-Based Gaps.
Topics: Acetaminophen; Acute Pain; Analgesia; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Humans; K | 2018 |
The role of ketamine in addressing the anesthesia gap in low-resource settings.
Topics: Abdominal Pain; Adolescent; Adult; Anesthesia; Anesthesiology; Anesthetists; Child; Developing Count | 2018 |
Ketamine has anti-hyperalgesic effects and relieves acute pain, but does not prevent persistent postoperative pain (PPP).
Topics: Acute Pain; Analgesics; Double-Blind Method; Humans; Hyperalgesia; Ketamine; Pain, Postoperative | 2015 |
Low-Dose Ketamine for Acute Pain Management: A Timely Nudge Toward Multimodal Analgesia.
Topics: Acute Pain; Analgesia; Analgesics; Dose-Response Relationship, Drug; Humans; Ketamine; Opioid-Relate | 2018 |
The effects of a combination of intravenous dexamethasone and ketamine on postoperative mood in patients undergoing laparoscopically assisted-gynecologic surgery.
Topics: Administration, Intravenous; Adult; Affect; Aged; Analgesics; Anti-Inflammatory Agents; Dexamethason | 2018 |
Low-Dose Ketamine for Postoperative Pain Management.
Topics: Analgesics; Dose-Response Relationship, Drug; Humans; Ketamine; Pain Management; Pain, Postoperative | 2018 |
Pain management in living related adult donor hepatectomy: feasibility of an evidence-based protocol in 100 consecutive donors.
Topics: Adult; Analgesia, Epidural; Anesthesia, Intravenous; Anesthetics; Clonidine; Evidence-Based Medicine | 2018 |
Pain management in living related adult donor hepatectomy: feasibility of an evidence-based protocol in 100 consecutive donors.
Topics: Adult; Analgesia, Epidural; Anesthesia, Intravenous; Anesthetics; Clonidine; Evidence-Based Medicine | 2018 |
Pain management in living related adult donor hepatectomy: feasibility of an evidence-based protocol in 100 consecutive donors.
Topics: Adult; Analgesia, Epidural; Anesthesia, Intravenous; Anesthetics; Clonidine; Evidence-Based Medicine | 2018 |
Pain management in living related adult donor hepatectomy: feasibility of an evidence-based protocol in 100 consecutive donors.
Topics: Adult; Analgesia, Epidural; Anesthesia, Intravenous; Anesthetics; Clonidine; Evidence-Based Medicine | 2018 |
Prevention of post-operative hyperalgesia in a heroin-addicted patient on methadone maintenance.
Topics: Analgesics, Opioid; Heroin; Humans; Hyperalgesia; Ketamine; Male; Methadone; Middle Aged; Opioid-Rel | 2019 |
Concerning the consensus guidelines on the use of ketamine.
Topics: Analgesics; Consensus; Humans; Infusions, Intravenous; Ketamine; Pain, Postoperative; Practice Guide | 2019 |
Effect of opioid-free anaesthesia on postoperative epidural ropivacaine requirement after thoracic surgery: A retrospective unmatched case-control study.
Topics: Aged; Analgesia, Epidural; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthetics, Local; Case-Co | 2019 |
Revision of expert panel's guidelines on postoperative pain management.
Topics: Adolescent; Adult; Analgesia, Epidural; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents, No | 2019 |
The importance of pain management in perioperative outcomes.
Topics: Analgesics; Analgesics, Opioid; Anesthesia, Conduction; Gabapentin; Humans; Ketamine; Pain Managemen | 2019 |
Pain Intensity in the First 96 Hours After Abdominal Surgery: A Prospective Cohort Study.
Topics: Age Factors; Aged; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthesia, Epidural; A | 2020 |
Effect of opioid-free anaesthesia on post-operative period in cardiac surgery: a retrospective matched case-control study.
Topics: Aged; Airway Extubation; Analgesics; Analgesics, Opioid; Anesthetics, Local; Antiemetics; Antihypert | 2019 |
Effect of opioid-free anaesthesia on post-operative period in cardiac surgery: a retrospective matched case-control study.
Topics: Aged; Airway Extubation; Analgesics; Analgesics, Opioid; Anesthetics, Local; Antiemetics; Antihypert | 2019 |
Effect of opioid-free anaesthesia on post-operative period in cardiac surgery: a retrospective matched case-control study.
Topics: Aged; Airway Extubation; Analgesics; Analgesics, Opioid; Anesthetics, Local; Antiemetics; Antihypert | 2019 |
Effect of opioid-free anaesthesia on post-operative period in cardiac surgery: a retrospective matched case-control study.
Topics: Aged; Airway Extubation; Analgesics; Analgesics, Opioid; Anesthetics, Local; Antiemetics; Antihypert | 2019 |
Effect of opioid-free anaesthesia on post-operative period in cardiac surgery: a retrospective matched case-control study.
Topics: Aged; Airway Extubation; Analgesics; Analgesics, Opioid; Anesthetics, Local; Antiemetics; Antihypert | 2019 |
Effect of opioid-free anaesthesia on post-operative period in cardiac surgery: a retrospective matched case-control study.
Topics: Aged; Airway Extubation; Analgesics; Analgesics, Opioid; Anesthetics, Local; Antiemetics; Antihypert | 2019 |
Effect of opioid-free anaesthesia on post-operative period in cardiac surgery: a retrospective matched case-control study.
Topics: Aged; Airway Extubation; Analgesics; Analgesics, Opioid; Anesthetics, Local; Antiemetics; Antihypert | 2019 |
Effect of opioid-free anaesthesia on post-operative period in cardiac surgery: a retrospective matched case-control study.
Topics: Aged; Airway Extubation; Analgesics; Analgesics, Opioid; Anesthetics, Local; Antiemetics; Antihypert | 2019 |
Effect of opioid-free anaesthesia on post-operative period in cardiac surgery: a retrospective matched case-control study.
Topics: Aged; Airway Extubation; Analgesics; Analgesics, Opioid; Anesthetics, Local; Antiemetics; Antihypert | 2019 |
[Opioid-sparing effect of ketamine during tonsillectomy in children].
Topics: Adolescent; Analgesics, Non-Narcotic; Anesthetics, Dissociative; Child; Child, Preschool; Drug Evalu | 2013 |
[Ketamine, makes happy... not always in children!].
Topics: Analgesics, Non-Narcotic; Female; Humans; Ketamine; Male; Pain, Postoperative; Tonsillectomy | 2013 |
The effects of intrathecal and systemic adjuvants on subarachnoid block.
Topics: Adjuvants, Anesthesia; Administration, Inhalation; Adrenal Cortex Hormones; Adrenergic alpha-Agonist | 2014 |
[A French survey on the practice of analgesia for thoracic surgery].
Topics: Analgesia; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthesia, Condu | 2013 |
[Pediatric perioperative systemic pain therapy: Austrian interdisciplinary recommendations on pediatric perioperative pain management].
Topics: Adolescent; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, P | 2014 |
Alfaxalone or ketamine-medetomidine in cats undergoing ovariohysterectomy: a comparison of intra-operative parameters and post-operative pain.
Topics: Anesthesia; Anesthetics; Anesthetics, Combined; Animals; Cats; Female; Hysterectomy; Intraoperative | 2014 |
Perioperative acupuncture: why are we not using it?
Topics: Electroacupuncture; Humans; Ketamine; Male; Pain, Postoperative; Tramadol | 2014 |
Ketamine is toxic to chondrocyte cell cultures.
Topics: Analgesics; Animals; Apoptosis; Cell Survival; Chondrocytes; Cumulus Cells; Injections, Intra-Articu | 2014 |
The factors of ketamine that affect sedation in children with oncology procedures: parent satisfaction perspective.
Topics: Adolescent; Anesthesia Recovery Period; Anesthetics, Dissociative; Child; Child, Preschool; Female; | 2014 |
Authors' reply.
Topics: Anesthesia; Anesthetics; Anesthetics, Combined; Animals; Female; Hysterectomy; Ketamine; Medetomidin | 2015 |
Application of fast-track surgery principles to evaluate effects of atipamezole on recovery and analgesia following ovariohysterectomy in cats anesthetized with dexmedetomidine-ketamine-hydromorphone.
Topics: Analgesics, Opioid; Anesthesia Recovery Period; Anesthetics, Combined; Anesthetics, Dissociative; An | 2015 |
Questions about the article: 'Alfaxalone or ketamine-medetomidine in cats undergoing ovariohysterectomy: a comparison of intraoperative parameters and postoperative pain'.
Topics: Anesthesia; Anesthetics; Anesthetics, Combined; Animals; Female; Hysterectomy; Ketamine; Medetomidin | 2015 |
Butorphanol and ketamine combined in infusion solutions for patient-controlled analgesia administration: a long-term stability study.
Topics: Analgesia, Patient-Controlled; Analgesics; Butorphanol; Chromatography, High Pressure Liquid; Drug S | 2015 |
Perioperative ketamine for acute postoperative analgesia: the Mayo Clinic-Florida experience.
Topics: Analgesics; Clinical Protocols; Florida; Humans; Ketamine; Pain, Postoperative; Perioperative Nursin | 2015 |
Revision of loop colostomy under regional anaesthesia and sedation.
Topics: Abdominal Wall; Aged; Anesthesia, Conduction; Anesthesia, General; Colostomy; Conscious Sedation; De | 2015 |
Low-Dose Ketamine Infusions for Postoperative Pain in Opioid-Tolerant Orthopaedic Spine Patients.
Topics: Analgesics; Analgesics, Opioid; Drug Resistance; Evidence-Based Practice; Humans; Infusions, Intrave | 2015 |
Potential strategies for preventing chronic postoperative pain: a practical approach: Continuing Professional Development.
Topics: Analgesics, Opioid; Anesthesia, Conduction; Anesthesia, Epidural; Anesthetics, Local; Chronic Pain; | 2015 |
Ketamine as an adjunct to patient-controlled analgesia: why, for whom, and how much?
Topics: Analgesia; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Double-Blind Method; Human | 2016 |
The effects of an intraperitoneal single low dose of ketamine in attenuating the postoperative skin/muscle incision and retraction-induced pain related to the inhibition of N-methyl-D-aspartate receptors in the spinal cord.
Topics: Analgesics; Animals; Injections, Intraperitoneal; Ketamine; Male; Muscle, Skeletal; Pain, Postoperat | 2016 |
[The Analgesic Sparing Effect of Ketamine for Postoperative Pain Management after Pediatric Surgery on the Body Surface].
Topics: Analgesics; Child; Child, Preschool; Excitatory Amino Acid Antagonists; Female; Humans; Infant; Infa | 2016 |
COMPARISON OF INTRAOPERATIVE KETAMINE VS. FENTANYL USE DECREASES POSTOPERATIVE OPIOID REQUIREMENTS IN TRAUMA PATIENTS UNDERGOING CERVICAL SPINE SURGERY.
Topics: Adult; Analgesics, Opioid; Cervical Vertebrae; Female; Fentanyl; Humans; Intraoperative Period; Keta | 2016 |
Effect of preemptive ketamine administration on postoperative visceral pain after gynecological laparoscopic surgery.
Topics: Adolescent; Adult; Analgesics; Female; Gynecologic Surgical Procedures; Humans; Ketamine; Laparoscop | 2016 |
A comparison of intrathecal magnesium and ketamine in attenuating remifentanil-induced hyperalgesia in rats.
Topics: Animals; Dose-Response Relationship, Drug; Hyperalgesia; Injections, Spinal; Ketamine; Magnesium Sul | 2016 |
The effect of low-dose ketamine via patient-controlled analgesic pump on morphine consumption in the postoperative period in thoracotomies: a systematic review protocol.
Topics: Analgesia, Patient-Controlled; Analgesics; Humans; Ketamine; Morphine; Pain, Postoperative; Systemat | 2016 |
Effectiveness of ketamine as an adjuvant to opioid-based therapy in decreasing pain associated with opioid tolerance in adults undergoing orthopedic surgery: a systematic review protocol.
Topics: Adolescent; Adult; Aged; Analgesics; Analgesics, Opioid; Chemotherapy, Adjuvant; Drug Tolerance; Hum | 2016 |
The influence of demeanor on scores from two validated feline pain assessment scales during the perioperative period.
Topics: Anesthesia; Animals; Cats; Dexmedetomidine; Hydromorphone; Imidazoles; Ketamine; Lidocaine; Male; Me | 2017 |
[Effects of preoperative ketamine on postoperative pain in patients undergoing laparotomy].
Topics: Female; Humans; Ketamine; Laparotomy; Male; Middle Aged; Pain, Postoperative; Preoperative Care; Ret | 2008 |
Clarification required regarding results of morphine PCA/ketamine trial.
Topics: Analgesia, Patient-Controlled; Analgesics, Opioid; Humans; Ketamine; Morphine; Pain, Postoperative | 2008 |
Adding midazolam to ketamine in the pediatric emergency department--it doesn't add up.
Topics: Anesthetics, Dissociative; Anesthetics, Intravenous; Drug Therapy, Combination; Emergency Medical Se | 2008 |
Dreaming of patients' satisfaction.
Topics: Anesthetics, Dissociative; Humans; Ketamine; Pain; Pain Measurement; Pain, Postoperative; Patient Sa | 2009 |
[Lumbar spine arthrodesis under general anesthesia in a patient allergic to fentanyl].
Topics: Aged; Amides; Analgesia, Epidural; Analgesics, Non-Narcotic; Androstanols; Anesthesia, General; Anes | 2009 |
[Ketamine for prevention of postoperative pain: what are the doses and indications?].
Topics: Adult; Analgesia, Patient-Controlled; Analgesics; Chronic Disease; Dose-Response Relationship, Drug; | 2009 |
Propofol alters ketamine effect on opiate-induced hyperalgesia.
Topics: Analgesics; Analgesics, Opioid; Anesthetics, Intravenous; Drug Interactions; Drug Tolerance; Humans; | 2009 |
Expert panel guidelines (2008). Postoperative pain management in adults and children. SFAR Committees on Pain and Local Regional Anaesthesia and on Standards.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Ambulatory Surgical Procedures; Analgesics, Non-Narcoti | 2009 |
Short-term anaesthesia with xylazine, diazepam/ketamine for castration in horses under field conditions: use of intravenous lidocaine.
Topics: Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Local; Animal | 2009 |
[Effects of general anesthesia using ketamine and remifentanil on postoperative pain management for patients undergoing laparotomy].
Topics: Adult; Aged; Anesthesia, General; Anti-Inflammatory Agents, Non-Steroidal; Elective Surgical Procedu | 2009 |
[Incident involving the prescription of ketamine outside the operating room].
Topics: Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics; Anesthetics, Local; Carcinoma; Consc | 2009 |
Low-dose ketamine infusion for postoperative pain management.
Topics: Analgesics; Dose-Response Relationship, Drug; Humans; Infusions, Intravenous; Ketamine; Pain, Postop | 2009 |
Fentanyl and ketamine used for postoperative pain control in high-risk patients with malignancy.
Topics: Analgesics, Opioid; Anesthetics, Dissociative; Fentanyl; Humans; Ketamine; Neoplasms; Pain, Postoper | 2009 |
[Ketamine racemate and fast track anaesthesia. Influence on recovery times and postoperative opioid needs].
Topics: Adult; Aged; Analgesics, Opioid; Anesthesia; Anesthesia Recovery Period; Anesthetics, Dissociative; | 2009 |
Assessment of the local effects of ketamine requires exclusion of systemic effects.
Topics: Anesthesia, Dental; Anesthetics, Dissociative; Anti-Inflammatory Agents; Humans; Ketamine; Pain, Pos | 2009 |
Postoperative pain relief with ketamine in patients with central sleep apnea.
Topics: Analgesics; Analgesics, Opioid; Fentanyl; Humans; Ketamine; Pain, Postoperative; Respiratory Insuffi | 2009 |
Opioid-induced hyperalgesia in a mice model of orthopaedic pain: preventive effect of ketamine.
Topics: Analgesics; Analgesics, Opioid; Animals; Disease Models, Animal; Drug Evaluation, Preclinical; Drug | 2010 |
Tyrosine phosphorylation of the N-Methyl-D-Aspartate receptor 2B subunit in spinal cord contributes to remifentanil-induced postoperative hyperalgesia: the preventive effect of ketamine.
Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Excitatory Amino Acid Antagonists; Glutamic Aci | 2009 |
Opioid-induced hyperalgesia: low-dose ketamine does work for some orthopaedic problems already.
Topics: Analgesics, Opioid; Excitatory Amino Acid Antagonists; Humans; Hyperalgesia; Ketamine; Orthopedic Pr | 2010 |
Ketamine for managing perioperative pain in opioid-dependent patients with chronic pain: a unique indication?
Topics: Chronic Disease; Disease Management; Humans; Ketamine; Opioid-Related Disorders; Pain; Pain, Postope | 2010 |
Intraoperative ketamine and chronic opioid use: less pain, more morphine?
Topics: Analgesics; Analgesics, Opioid; Chronic Disease; Follow-Up Studies; Humans; Intraoperative Care; Ket | 2011 |
[An algorithm for postoperative pain management in visceral and thoracic surgery: an observational study].
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Algorithms; Amines; Analgesia, Epidural; Analgesics; | 2013 |
Deleterious impact of a γ-aminobutyric acid type A receptor preferring general anesthetic when used in the presence of persistent inflammation.
Topics: Adrenergic alpha-Agonists; Anesthesia, General; Anesthetics, General; Animals; Behavior, Animal; Exc | 2011 |
Does ketamine improve postoperative analgesia? More questions than answers.
Topics: Analgesia; Analgesics; Female; Humans; Ketamine; Male; Narcotics; Pain, Postoperative; Spine | 2011 |
[Patient-controlled epidural analgesia combined with patient-controlled intravenous analgesia for postoperative analgesia after Miles' operation for rectal cancer].
Topics: Aged; Amides; Analgesia, Epidural; Analgesia, Patient-Controlled; Anesthesia, General; Digestive Sys | 2011 |
Pharmacokinetics and physiologic effects of intramuscularly administered xylazine hydrochloride-ketamine hydrochloride-butorphanol tartrate alone or in combination with orally administered sodium salicylate on biomarkers of pain in Holstein calves followi
Topics: Administration, Oral; Analgesics; Analysis of Variance; Animals; Area Under Curve; Biomarkers, Pharm | 2011 |
Use of ketamine in children - what are the next steps?
Topics: Anesthetics, Dissociative; Female; Humans; Ketamine; Male; Pain, Postoperative; Perioperative Care | 2011 |
No need for NMDA-receptor antagonists in women undergoing caesarean section?
Topics: Anesthesia, General; Anesthetics, Dissociative; Cesarean Section; Female; Humans; Ketamine; Pain, Po | 2012 |
How much esmolol was administered?
Topics: Cholecystectomy, Laparoscopic; Female; Humans; Ketamine; Male; Pain, Postoperative; Piperidines; Pro | 2012 |
[Effect of sub-anaesthetic doses of ketamine in the postoperative period in a patient with uncontrolled depression].
Topics: Adenocarcinoma; Analgesics; Antidepressive Agents; Antineoplastic Agents, Hormonal; Bone Neoplasms; | 2013 |
Ketamine for analgesia.
Topics: Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Drug Therapy, Combination; Humans; Ke | 2012 |
Ketamine and postoperative nausea and vomiting: role of the morphine-sparing effect.
Topics: Adolescent; Adult; Aged; Analgesics, Opioid; Dose-Response Relationship, Drug; Excitatory Amino Acid | 2012 |
Ketamine for pain management.
Topics: Analgesics; Humans; Ketamine; Pain, Postoperative; Postanesthesia Nursing | 2012 |
Nefopam after total hip arthroplasty: role in multimodal analgesia.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Arthroplasty | 2013 |
The effect of addition of pregabalin and s-ketamine to local infiltration analgesia on the knee function outcome after total knee arthroplasty.
Topics: Acetaminophen; Aged; Analgesia; Analgesics; Analgesics, Non-Narcotic; Anesthetics, Dissociative; Art | 2012 |
NMDA receptors offer more than one functionality.
Topics: Depressive Disorder; Excitatory Amino Acid Antagonists; Humans; Ketamine; Pain Measurement; Pain, Po | 2003 |
Combinations of morphine with ketamine for patient-controlled analgesia: a new optimization method.
Topics: Adolescent; Adult; Aged; Analgesia, Patient-Controlled; Analgesics; Arthroplasty, Replacement, Hip; | 2003 |
Ketamine added to intravenous patient-controlled morphine: ketamine plasma concentration is unreliable.
Topics: Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Humans; Ketamine; Magnesium; Morphine | 2004 |
[Increase in bispectral index induced by antihyperalgesic dose of ketamine].
Topics: Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, Dissociative; Anesthetics, Inhal | 2004 |
Effect of intratesticular injection of xylazine/ketamine combination on canine castration.
Topics: Anesthesia, Intravenous; Anesthetics, Combined; Anesthetics, Dissociative; Animals; Body Temperature | 2004 |
Are preemptive analgesic effects of ketamine linked to inadequate perioperative analgesia?
Topics: Analgesia; Anesthetics, Dissociative; Chronic Disease; Female; Gynecologic Surgical Procedures; Huma | 2004 |
Ketamine improves the management of exaggerated postoperative pain observed in perioperative fentanyl-treated rats.
Topics: Animals; Disease Models, Animal; Drug Synergism; Fentanyl; Hindlimb; Ketamine; Male; Pain, Postopera | 2005 |
Systemic ketamine inhibits hypersensitivity after surgery via descending inhibitory pathways in rats.
Topics: Analgesics; Animals; Ketamine; Male; Methysergide; Neural Inhibition; Pain, Postoperative; Proto-Onc | 2005 |
Safety of mixture of morphine with ketamine for postoperative patient-controlled analgesia: an audit with 1026 patients.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesia, Patient-Controlled; Analgesics, Opioid; Anest | 2005 |
Preventive analgesia to reduce wound hyperalgesia and persistent postsurgical pain: not an easy path.
Topics: Analgesia, Epidural; Humans; Hyperalgesia; Ketamine; Pain, Postoperative | 2005 |
[Comparison of the suppressive effects of tramadol and low-dose ketamine on the patients with postoperative hyperalgesia after remifentanil-based anaesthesia].
Topics: Adult; Analgesics, Opioid; Anesthesia; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain, Post | 2005 |
Ketamine-xylazine-acepromazine anesthesia and postoperative recovery in rats.
Topics: Acepromazine; Anesthesia; Anesthetics, Combined; Animals; Animals, Laboratory; Anti-Inflammatory Age | 2006 |
Use of ketamine to facilitate opioid withdrawal in a child.
Topics: Analgesics, Opioid; Anesthetics, Dissociative; Child, Preschool; Female; Fentanyl; Humans; Ketamine; | 2006 |
Pain relief after daycase tonsillectomy in children.
Topics: Ambulatory Surgical Procedures; Analgesics; Anesthesia, General; Child; Humans; Ketamine; Pain, Post | 2006 |
Earthquake injuries and the use of ketamine for surgical procedures: the Kashmir experience.
Topics: Adolescent; Adult; Aged; Anesthetics, Dissociative; Child; Child, Preschool; Disasters; Emergency Me | 2006 |
Evidence-based pain management and palliative care in Issue One for 2006 of The Cochrane Library.
Topics: Analgesics; Analgesics, Opioid; Clinical Trials as Topic; Cryotherapy; Evidence-Based Medicine; Huma | 2006 |
Opioid-induced hyperalgesia.
Topics: Analgesics; Analgesics, Opioid; Femoral Artery; Fentanyl; Humans; Hyperalgesia; Ketamine; Male; Midd | 2007 |
Adjunct continuous intravenous ketamine infusion for postoperative pain relief following posterior spinal instrumentation for correction of scoliosis: a case report.
Topics: Adolescent; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Drug Therapy, Combination | 2007 |
Morphine versus morphine-ketamine association in the management of post operative pain in thoracic surgery.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, Dissociative; Drug Combinatio | 2007 |
Re: the efficacy of intravenous or peritonsillar infiltration of ketamine for postoperative pain relief in children following adenotonsillectomy.
Topics: Adenoidectomy; Anesthesia, Local; Anesthetics, Dissociative; Child; Child, Preschool; Humans; Inject | 2007 |
Ketamine and spinal instrumentation.
Topics: Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Humans; Ketamine; Pain, Postoperative | 2007 |
The ketamine enigma.
Topics: Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Drug Therapy, Combination; Humans; Ke | 2008 |
[Combined transgluteal ischial and femoral nerve block: retrospective data on 65 risk patients with leg amputation].
Topics: Adult; Aged; Aged, 80 and over; Amputation, Surgical; Analgesia, Patient-Controlled; Anesthesia, Con | 2008 |
Management of post-operative pain: current concepts and methods of management.
Topics: Acupuncture Therapy; Analgesics, Opioid; Anesthesia, Inhalation; Biofeedback, Psychology; Humans; Hy | 1983 |
The selection of drugs in office surgery.
Topics: Ambulatory Surgical Procedures; Analgesics; Anesthesia; Anesthetics, Local; Humans; Hypnotics and Se | 1983 |
Ketamine on demand for postoperative analgesia.
Topics: Adult; Analgesia; Female; Humans; Ketamine; Male; Pain, Postoperative | 1981 |
Ketamine on demand for postoperative analgesia.
Topics: Humans; Ketamine; Pain, Postoperative; Self Administration | 1981 |
Effect of ketamine, an NMDA receptor inhibitor, in acute and chronic orofacial pain.
Topics: Acute Disease; Adult; Aged; Chronic Disease; Facial Pain; Female; Follow-Up Studies; Humans; Inciden | 1995 |
Beneficial effects of ketamine in a chronic pain state with allodynia, possibly due to central sensitization.
Topics: Adolescent; Appendectomy; Brain; Chronic Disease; Female; Humans; Ketamine; Pain, Postoperative; Reo | 1995 |
Pain management with ketamine: a case study.
Topics: Crohn Disease; Humans; Ketamine; Nursing Staff, Hospital; Pain, Postoperative; Patient Education as | 1994 |
Another explanation for reduced meperidine consumption in the immediate postoperative period.
Topics: Drug Interactions; Fentanyl; Humans; Ketamine; Meperidine; Pain, Postoperative; Postoperative Period | 1995 |
Ketamine infusion for postoperative analgesia: a prospective cohort study in asthmatics.
Topics: Adult; Analgesia; Asthma; Cohort Studies; Diazepam; Female; Humans; Infusions, Intravenous; Ketamine | 1993 |
Ketamine infusion for postoperative analgesia in asthmatics: a comparison with intermittent meperidine.
Topics: Adult; Asthma; Bronchial Spasm; Female; Humans; Hysterectomy; Infusions, Intravenous; Ketamine; Mepe | 1993 |
Intravenous ketamine or fentanyl prolongs postoperative analgesia after intrathecal neostigmine.
Topics: Analgesia; Analgesics, Opioid; Anesthesia, Spinal; Anesthetics, Dissociative; Anesthetics, Intraveno | 1996 |
Ketamine: its mechanism(s) of action and unusual clinical uses.
Topics: Analgesia; Anesthesia, Local; Anesthetics, Dissociative; Critical Illness; Humans; Ketamine; Pain, P | 1996 |
Pre-emptive analgesia with ketamine, morphine and epidural lidocaine prior to total knee replacement.
Topics: Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthesia, Epidural; Anesth | 1997 |
Compatibility of ketamine hydrochloride and meperidine hydrochloride.
Topics: Analgesics, Opioid; Anesthetics, Intravenous; Drug Incompatibility; Female; Humans; Hysterectomy; Ke | 1997 |
Analgesia following thoracotomy: a survey of Australian practice.
Topics: Acetaminophen; Analgesia; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics, Non-Narcot | 1997 |
Analgesia following thoracotomy: a survey of Australian practice.
Topics: Acetaminophen; Analgesia; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics, Non-Narcot | 1997 |
Analgesia following thoracotomy: a survey of Australian practice.
Topics: Acetaminophen; Analgesia; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics, Non-Narcot | 1997 |
Analgesia following thoracotomy: a survey of Australian practice.
Topics: Acetaminophen; Analgesia; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics, Non-Narcot | 1997 |
Epidural ketamine for postoperative analgesia.
Topics: Analgesia, Epidural; Excitatory Amino Acid Antagonists; Humans; Ketamine; Pain, Postoperative | 1998 |
[Pharmacokinetics of propofol and ketamine during and after total intravenous anesthesia with propofol, fentanyl and ketamine for pediatric patients].
Topics: Anesthesia, Intravenous; Anesthetics, Intravenous; Child; Child, Preschool; Fentanyl; Humans; Ketami | 1998 |
Ketamine as an adjunct to morphine in postthoracotomy analgesia: an unintended N-of-1 study.
Topics: Analgesics, Opioid; Humans; Ketamine; Male; Middle Aged; Morphine; Pain, Postoperative; Thoracotomy | 1998 |
Postoperative pain after ovariohysterectomy in the cat: a comparison of two anaesthetic regimens.
Topics: Acepromazine; Analgesics, Non-Narcotic; Anesthetics, Dissociative; Anesthetics, Inhalation; Anesthet | 1998 |
Treatment of pain in trauma patients with injuries of the upper limb.
Topics: Analgesics, Opioid; Anesthesia, Conduction; Arm Injuries; Contraindications; Humans; Ketamine; Meper | 2000 |
Tramadol or ketamine for caudal analgesia?
Topics: Analgesia, Epidural; Analgesics, Opioid; Anesthetics, Dissociative; Child; Child, Preschool; Ethics, | 2000 |
Neural toxicity of ketamine and othe NMDA antagonists.
Topics: Analgesics; Animals; Humans; Ketamine; Pain, Postoperative; Rats; Receptors, N-Methyl-D-Aspartate | 2000 |
When is preemptive analgesia truly preemptive?
Topics: Analgesia, Epidural; Analgesics; Analgesics, Opioid; Humans; Injections, Intravenous; Ketamine; Morp | 2001 |
Preemptive analgesia by intravenous low-dose ketamine and epidural morphine.
Topics: Analgesia, Epidural; Analgesics; Analgesics, Opioid; Humans; Injections, Intravenous; Ketamine; Morp | 2001 |
Improved, but not preemptive, analgesia.
Topics: Analgesia, Epidural; Analgesics; Analgesics, Opioid; Humans; Injections, Intravenous; Ketamine; Morp | 2001 |
The role of ketamine in preventing fentanyl-induced hyperalgesia and subsequent acute morphine tolerance.
Topics: Analgesics, Opioid; Animals; Drug Tolerance; Excitatory Amino Acid Antagonists; Fentanyl; Hyperalges | 2002 |
Ketamine combined with morphine for the management of pain in an opioid addict.
Topics: Adult; Anesthetics, Intravenous; Female; Humans; Ketamine; Opioid-Related Disorders; Pain Measuremen | 2002 |
Postoperative analgesia.
Topics: Humans; Ketamine; Meperidine; Pain, Postoperative | 1979 |
Letter: Caudal block for post-operative pain relief in children.
Topics: Adult; Anesthesia, Spinal; Bupivacaine; Child; Circumcision, Male; Epinephrine; Humans; Ketamine; Ma | 1975 |
Postoperative ketamine analgesia in children: efficacy and safety after halothane anesthesia.
Topics: Anesthesia; Child; Child Behavior; Child, Preschool; Drug Evaluation; Drug Therapy, Combination; Hal | 1988 |
Epidural ketamine for postoperative analgesia.
Topics: Humans; Injections, Epidural; Ketamine; Pain, Postoperative | 1988 |
Pulmonary function and analgesic effect after epidural ketamine for postoperative pain relief.
Topics: Adult; Aged; Analgesics; Drug Evaluation; Female; Humans; Injections, Epidural; Injections, Intramus | 1988 |
Dissociative anaesthesia for coronary artery bypass surgery using ketamine and midazolam. A case report.
Topics: Anesthesia, Intravenous; Coronary Artery Bypass; Drug Hypersensitivity; Humans; Intraoperative Care; | 1986 |
Epidural ketamine for postoperative analgesia.
Topics: Humans; Injections, Epidural; Ketamine; Pain, Postoperative | 1987 |
Epidural ketamine for control of postoperative pain: two comments.
Topics: Anesthesia, Epidural; Humans; Ketamine; Pain, Postoperative | 1986 |
Epidural ketamine for postoperative pain relief.
Topics: Adult; Aged; Female; Humans; Injections, Epidural; Ketamine; Male; Middle Aged; Pain, Postoperative | 1986 |
[Postoperative analgesia by the continuous peridural administration of ketamine].
Topics: Adolescent; Adult; Aged; Epidural Space; Female; Humans; Injections; Ketamine; Male; Middle Aged; Pa | 1985 |
Epidural ketamine for control of postoperative pain.
Topics: Adult; Epidural Space; Female; Humans; Injections; Ketamine; Male; Middle Aged; Pain, Postoperative | 1985 |
Caudal block for post-operative pain relief in children.
Topics: Anesthesia, Intravenous; Anesthesia, Spinal; Bupivacaine; Circumcision, Male; Epinephrine; Humans; I | 1974 |
Post-operative pain relief with ketamine infusion.
Topics: Adult; Aged; Anesthesia, General; Blood Pressure; Cholecystectomy; Dreams; Female; Gastrectomy; Huma | 1974 |