Page last updated: 2024-09-27

Fractures, Multiple

Injuries involving the breaking of either several bones or one bone in two or more places.

Synonyms(1)

Synonym
Fractures, Multiple

Research

Studies (32)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's0 (0.00)18.1394
2010's18 (56.25)28.8240
2020's14 (43.75)9.53
DrugIndicatedRelationship StrengthStudiesTrials
lactic acid0low10
bupivacaine0low10
lidocaine0low10
apnea0low10
thyroxine0low10
ergotamine0low10
durapatite0low10
titanium0low10
propiconazole0low30
6-amino-1-hydroxyhexane-1,1-diphosphonate0low10
methotrexate0low10
ropivacaine0low40
acitretin0low10
dexmedetomidine0medium11
indocyanine green0low10
acid phosphatase0low10
technetium tc 99m sestamibi0low10
mme0low10
eye0low10

Protein Targets (329)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Geranylgeranyl pyrophosphate synthase0101
Farnesyl pyrophosphate synthase0202
Chain A, JmjC domain-containing histone demethylation protein 3A1001
Luciferase1001
USP1 protein, partial3003
TDP1 protein6006
Microtubule-associated protein tau4004
AR protein5005
aldehyde dehydrogenase 1 family, member A13003
glucocorticoid receptor [Homo sapiens]2002
estrogen nuclear receptor alpha5005
peroxisome proliferator activated receptor gamma4004
euchromatic histone-lysine N-methyltransferase 26006
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a3003
vitamin D3 receptor isoform VDRA3003
thyroid hormone receptor beta isoform 24004
flap endonuclease 13003
serine/threonine-protein kinase PLK12002
eyes absent homolog 2 isoform a1001
DNA polymerase eta isoform 13003
geminin4004
peripheral myelin protein 223003
survival motor neuron protein isoform d2002
histone acetyltransferase KAT2A isoform 12002
ATP-binding cassette sub-family C member 30404
Multidrug resistance-associated protein 40405
Bile salt export pump0202
Bile salt export pump0606
Rap guanine nucleotide exchange factor 33003
Cellular tumor antigen p534004
Rap guanine nucleotide exchange factor 41001
thioredoxin reductase4004
ATAD5 protein, partial2002
estrogen-related nuclear receptor alpha5005
arylsulfatase A1001
Bloom syndrome protein isoform 12002
D(1A) dopamine receptor1001
lamin isoform A-delta107007
neuropeptide S receptor isoform A1001
Potassium channel subfamily K member 30303
Potassium channel subfamily K member 30101
Potassium channel subfamily K member 20112
Potassium channel subfamily K member 90101
thyroid stimulating hormone receptor1001
Alpha-1B adrenergic receptor 0011
cytochrome P450 2D6 isoform 11001
cellular tumor antigen p53 isoform a3003
cytochrome P450 2C19 precursor1001
cytochrome P450 2C9 precursor1001
cytochrome P450 3A4 isoform 12002
Gamma-aminobutyric acid receptor subunit pi2002
Alpha-2A adrenergic receptor0325
Gamma-aminobutyric acid receptor subunit beta-12002
Alpha-1B adrenergic receptor0101
Alpha-1A adrenergic receptor0011
Gamma-aminobutyric acid receptor subunit delta2002
Gamma-aminobutyric acid receptor subunit gamma-22002
Alpha-2C adrenergic receptor0314
Alpha-2B adrenergic receptor0101
Gamma-aminobutyric acid receptor subunit alpha-52002
Gamma-aminobutyric acid receptor subunit alpha-32002
Alpha-2C adrenergic receptor0101
Alpha-2A adrenergic receptor0101
Gamma-aminobutyric acid receptor subunit gamma-12002
Gamma-aminobutyric acid receptor subunit alpha-22002
Alpha-1D adrenergic receptor0101
Alpha-1D adrenergic receptor0303
Gamma-aminobutyric acid receptor subunit alpha-42002
Gamma-aminobutyric acid receptor subunit gamma-32002
Gamma-aminobutyric acid receptor subunit alpha-62002
Alpha-1A adrenergic receptor0101
Histamine H2 receptor2002
Gamma-aminobutyric acid receptor subunit alpha-12002
Gamma-aminobutyric acid receptor subunit beta-32002
Gamma-aminobutyric acid receptor subunit beta-22002
GABA theta subunit2002
Gamma-aminobutyric acid receptor subunit epsilon2002
Adenylate cyclase 0101
5-hydroxytryptamine receptor 40202
Tyrosine-protein kinase Lck0101
Tyrosine-protein kinase Fyn0101
ATP-dependent translocase ABCB10202
Beta-2 adrenergic receptor0202
ATP-dependent translocase ABCB10202
Beta-1 adrenergic receptor0202
Cytochrome P450 3A40314
D(2) dopamine receptor0202
Alpha-2B adrenergic receptor0202
5-hydroxytryptamine receptor 1A0202
ATP-dependent translocase ABCB10202
D(1A) dopamine receptor0202
Sodium-dependent dopamine transporter0101
Thromboxane-A synthase 0101
5-hydroxytryptamine receptor 1D0101
5-hydroxytryptamine receptor 1B0101
5-hydroxytryptamine receptor 2A0202
5-hydroxytryptamine receptor 2C0202
5-hydroxytryptamine receptor 1B0202
D(3) dopamine receptor0202
5-hydroxytryptamine receptor 2B0202
5-hydroxytryptamine receptor 5A0101
5-hydroxytryptamine receptor 60202
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE3003
cytochrome P450 family 3 subfamily A polypeptide 43003
pregnane X nuclear receptor3003
chromobox protein homolog 14004
Glutamate receptor ionotropic, NMDA 2D0101
Acetylcholinesterase0202
Glutamate receptor ionotropic, NMDA 3B0101
Glutamate receptor ionotropic, NMDA 1 0202
Sodium channel protein type 4 subunit alpha0202
Cholinesterase0101
Glutamate receptor ionotropic, NMDA 2A 0202
Glutamate receptor ionotropic, NMDA 2B0202
Glutamate receptor ionotropic, NMDA 2C0202
Glutamate receptor ionotropic, NMDA 10202
Glutamate receptor ionotropic, NMDA 2A0202
Glutamate receptor ionotropic, NMDA 2B0202
Glutamate receptor ionotropic, NMDA 2C0101
Glutamate receptor ionotropic, NMDA 2D0202
Glutamate receptor ionotropic, NMDA 3A0101
Glutamate receptor ionotropic, NMDA 3B0202
Canalicular multispecific organic anion transporter 10303
Glutamate receptor ionotropic, NMDA 3A0202
acetylcholinesterase1001
RAR-related orphan receptor gamma4004
estrogen receptor 2 (ER beta)3003
retinoic acid nuclear receptor alpha variant 12002
cytochrome P450 2D61001
thyroid stimulating hormone receptor1001
v-jun sarcoma virus 17 oncogene homolog (avian)2002
Integrin beta-32002
Integrin alpha-IIb2002
Chain A, Beta-lactamase2002
GLS protein1001
vitamin D (1,25- dihydroxyvitamin D3) receptor2002
IDH12002
mitogen-activated protein kinase 11001
muscarinic acetylcholine receptor M11001
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 2 subunit alpha0101
Sodium channel protein type 3 subunit alpha0101
Potassium voltage-gated channel subfamily A member 50101
Potassium voltage-gated channel subfamily H member 20202
Sodium channel protein type 5 subunit alpha0101
Sodium channel protein type 9 subunit alpha0101
Potassium voltage-gated channel subfamily D member 20101
Potassium channel subfamily K member 180101
Multidrug and toxin extrusion protein 10101
Sodium channel protein type 3 subunit alpha0101
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain A, TYROSYL-DNA PHOSPHODIESTERASE1001
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain A, HADH2 protein1001
Chain B, HADH2 protein1001
Chain A, 2-oxoglutarate Oxygenase1001
Chain A, Ferritin light chain2002
acid sphingomyelinase1001
dopamine D1 receptor1001
ClpP1001
15-lipoxygenase, partial1001
phosphopantetheinyl transferase2002
nuclear receptor subfamily 1, group I, member 33003
progesterone receptor2002
EWS/FLI fusion protein3003
retinoid X nuclear receptor alpha2002
farnesoid X nuclear receptor2002
67.9K protein1001
peroxisome proliferator-activated receptor delta3003
Thymidylate synthase 0101
alpha-galactosidase1001
Thymidylate synthase 0101
Histone H2A.x1001
polyunsaturated fatty acid lipoxygenase ALOX121001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 11001
nuclear factor erythroid 2-related factor 2 isoform 21001
transcriptional regulator ERG isoform 31001
importin subunit beta-1 isoform 11001
DNA polymerase beta1001
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]0101
snurportin-11001
nuclear factor erythroid 2-related factor 2 isoform 13003
peptidyl-prolyl cis-trans isomerase NIMA-interacting 12002
DNA polymerase iota isoform a (long)2002
transactivating tegument protein VP16 [Human herpesvirus 1]0101
DNA polymerase kappa isoform 12002
M-phase phosphoprotein 81001
muscleblind-like protein 1 isoform 11001
caspase-1 isoform alpha precursor1001
nuclear receptor coactivator 3 isoform a0101
Toll-like receptor 40101
Fatty-acid amide hydrolase 10101
ATP-binding cassette sub-family C member 30102
Voltage-dependent calcium channel gamma-2 subunit2002
Dihydrofolate reductase0203
Dihydrofolate reductase0203
Dihydrofolate reductase 0101
Dihydrofolate reductase0101
Dihydrofolate reductase0101
Dihydrofolate reductase0203
Thymidylate synthase0101
Tyrosine-protein kinase ABL10011
Carbonic anhydrase 20011
Thymidylate synthase0202
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Thymidylate synthase0202
5-hydroxytryptamine receptor 2C0102
High mobility group protein B10011
Dihydrofolate reductase0101
Thymidylate synthase0101
Dihydrofolate reductase0224
Glucose-6-phosphate 1-dehydrogenase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Folate receptor beta0101
5-hydroxytryptamine receptor 2A0101
Cytochrome P450 11B1, mitochondrial 0101
Folate receptor alpha0101
Dihydrofolate reductase0202
Histidine decarboxylase0112
Glutamate receptor 22002
Trifunctional purine biosynthetic protein adenosine-30101
Cyclin-dependent kinase 20011
Bifunctional purine biosynthesis protein ATIC0202
Multidrug resistance-associated protein 1 0001
Delta-type opioid receptor0315
Mu-type opioid receptor0317
Kappa-type opioid receptor0315
Reduced folate transporter0202
Folylpolyglutamate synthase, mitochondrial0103
6-phosphogluconate dehydrogenase, decarboxylating0101
Caspase-71001
Spike glycoprotein1001
Solute carrier organic anion transporter family member 1A30002
Dihydrofolate reductase0101
Pteridine reductase 10101
Folylpolyglutamate synthase, mitochondrial0103
Bifunctional dihydrofolate reductase-thymidylate synthase0101
TAR DNA-binding protein 432002
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Solute carrier family 22 member 60001
Canalicular multispecific organic anion transporter 10102
Trifunctional purine biosynthetic protein adenosine-30101
Solute carrier family 22 member 200101
Dihydrofolate reductase 0101
Solute carrier family 22 member 80001
Solute carrier family 22 member 60101
Dihydrofolate reductase0101
ATP-binding cassette sub-family C member 110001
Proton-coupled folate transporter0101
Multidrug resistance associated protein0102
ATPase family AAA domain-containing protein 52002
Ataxin-22002
Solute carrier organic anion transporter family member 1B30001
Solute carrier family 22 member 110001
Protein-arginine deiminase type-40101
Broad substrate specificity ATP-binding cassette transporter ABCG20001
ATP-dependent phosphofructokinase1001
Opioid receptor, delta 1b 0101
Solute carrier family 22 member 1 0101
Opioid receptor homologue0101
Acyl-CoA desaturase 10101
Muscarinic acetylcholine receptor M10101
Muscarinic acetylcholine receptor M30101
Muscarinic acetylcholine receptor M40101
Muscarinic acetylcholine receptor M50101
Muscarinic acetylcholine receptor M20101
Translocator protein0011
Proteinase-activated receptor 10112
Sodium-dependent serotonin transporter0101
Delta-type opioid receptor0102
Kappa-type opioid receptor0214
Mu-type opioid receptor0214
UDP-glucuronosyltransferase 1A30001
Delta-type opioid receptor0214
Kappa-type opioid receptor0202
Kappa-type opioid receptor0214
Mu-type opioid receptor0215
Nociceptin receptor0101
5-hydroxytryptamine receptor 70101
Mu-type opioid receptor0101
Mu-type opioid receptor0202
Beta-2 adrenergic receptor0101
Mas-related G-protein coupled receptor member X20011
Mu-type opioid receptor0101
Sigma non-opioid intracellular receptor 10101
glp-1 receptor, partial1001
pregnane X receptor1001
SMAD family member 21001
SMAD family member 31001
GLI family zinc finger 31001
nonstructural protein 11001
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
aryl hydrocarbon receptor2002
thyroid hormone receptor beta isoform a2002
heat shock protein HSP 90-alpha isoform 20001
nuclear receptor ROR-gamma isoform 11001
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
Guanine nucleotide-binding protein G1001
heat shock protein 90, putative0001
Chain X, Thyroid hormone receptor beta-10011
Chain X, Thyroid hormone receptor beta-10011
apical membrane antigen 1, AMA11001
G1001
Solute carrier organic anion transporter family member 1A40001
Nuclear receptor subfamily 1 group I member 20011
Solute carrier organic anion transporter family member 1A50001
Interferon beta1001
HLA class I histocompatibility antigen, B alpha chain 1001
Transthyretin0102
Thyroid hormone receptor alpha0011
Thyroid hormone receptor beta0011
Proliferating cell nuclear antigen0101
Retinoic acid receptor RXR-alpha0022
UDP-glucuronosyltransferase 1A1 0101
Peroxisome proliferator-activated receptor gamma0022
Malate dehydrogenase, mitochondrial0101
Solute carrier organic anion transporter family member 1A20001
Solute carrier organic anion transporter family member 4C10101
Monocarboxylate transporter 80001
Inositol hexakisphosphate kinase 11001
Bile acid receptor0101
Solute carrier organic anion transporter family member 1C10001
Solute carrier organic anion transporter family member 1B10001
cytochrome P450 2C9, partial1001
Chain A, PLASMINOGEN0011
Chain A, PLASMINOGEN0011
Plasminogen0213
Urokinase-type plasminogen activator0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]