Page last updated: 2024-10-29

ketamine and Tongue Neoplasms

ketamine has been researched along with Tongue Neoplasms in 2 studies

Ketamine: A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.
ketamine : A member of the class of cyclohexanones in which one of the hydrogens at position 2 is substituted by a 2-chlorophenyl group, while the other is substituted by a methylamino group.

Tongue Neoplasms: Tumors or cancer of the TONGUE.

Research

Studies (2)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	2 (100.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Carter, MJ	1
Gibbins, J	1
Senior-Smith, G	1
Thomas, S	1
Guest, P	1
Forbes, K	1
Slatkin, NE	1
Rhiner, M	1

Clinical Trials (1)

Trial Overview

Trial			Phase	Enrollment	Study Type	Start Date	Status
Treatment of Severe Mucositis Pain With Oral Ketamine Mouthwash[NCT01566448]			Phase 2	30 participants (Actual)	Interventional	2012-02-29	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change in Pain Scores

Change in pain score as reported at baseline and after the use of ketamine mouthwash on a numeric scale from 0 to 10, with 0 representing no pain and 10 representing the worst pain. (NCT01566448)
Timeframe: 1 hour after baseline

Intervention	score on a scale (Median)
Ketamine	2

Change in Sleep Quality

Sleep quality, as reported by the subject on a numeric scale (1-10) will be used as a surrogate marker of quality of life with 0 indicating no sleep and 10 indicating the best sleep you have had. (NCT01566448)
Timeframe: Day 1 after start of ketamine mouthwashes

Intervention	score on a scale (Median)
Ketamine	1

Change in Topical Lidocaine Usage

Change of topical lidocaine uses in 24 hour period (NCT01566448)
Timeframe: Days 1 after start of ketamine mouthwashes

Intervention	lidocaine doses per day (Median)
Ketamine	1

Change in Use of Narcotic Analgesics

Change in IV morphine equivalents of opioid requirements (NCT01566448)
Timeframe: Days 1 after start of ketamine mouthwashes

Intervention	IV morphine equivalents (Median)
Ketamine	12

Other Studies

2 other studies available for ketamine and Tongue Neoplasms

Article	Year
Ketamine: does it have a role in palliative sedation? Journal of pain and symptom management, 2008, Volume: 36, Issue:4 Topics: Analgesics; Facial Pain; Humans; Ketamine; Male; Palliative Care; Tongue Neoplasms; Treatment Outcom	2008
Topical ketamine in the treatment of mucositis pain. Pain medicine (Malden, Mass.), 2003, Volume: 4, Issue:3 Topics: Adult; Analgesics; Carcinoma, Squamous Cell; Excitatory Amino Acid Antagonists; Female; Humans; Keta	2003