ketamine has been researched along with Bilateral Headache in 17 studies
Ketamine: A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.
ketamine : A member of the class of cyclohexanones in which one of the hydrogens at position 2 is substituted by a 2-chlorophenyl group, while the other is substituted by a methylamino group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Intranasal ketamine and intravenous ketorolac both effectively reduced headaches." | 9.51 | Comparison of the efficacy of intranasal ketamine versus intravenous ketorolac on acute non-traumatic headaches: a randomized double-blind clinical trial. ( Baigrezaii, H; Meysami, A; Nazarianpirdosti, M; Safari-Faramani, R; Sarvari, HR, 2022) |
| " intranasal ketamine among ED patients with primary headache." | 9.30 | The THINK (Treatment of Headache with Intranasal Ketamine) Trial: A Randomized Controlled Trial Comparing Intranasal Ketamine with Intravenous Metoclopramide. ( April, MD; Benish, T; Casmaer, M; Hunter, CJ; Love, S; Summers, SM; Villalobos, D, 2019) |
| "The results suggested that it is possible to improve symptoms of depression earlier by using ketamine anesthesia." | 9.14 | Rapid antidepressant effect of ketamine anesthesia during electroconvulsive therapy of treatment-resistant depression: comparing ketamine and propofol anesthesia. ( Higuchi, T; Nagafusa, Y; Nakai, T; Nishikawa, T; Okamoto, N; Sakamoto, K, 2010) |
| " We present a case of SUNCT syndrome with successful pain relief by intravenous administration of ketamine, an N-methyl-D-aspartate receptor (NMDAR) antagonist." | 8.02 | Pain Relief in Short-Lasting Unilateral Neuralgiform Headache with Conjunctival inJection and Tearing Syndrome with Intravenous Ketamine: A Case Report. ( Kawabata, K; Sago, T; Shiiba, S, 2021) |
| "Intravenous subdissociative-dose ketamine has been shown to be effective for pain management, but has not been specifically studied for headaches in the emergency department (ED)." | 7.88 | A Comparison of Headache Treatment in the Emergency Department: Prochlorperazine Versus Ketamine. ( Bartlett, A; Clark, JM; Forred, W; Gates, M; Patel, J; Pitotti, C; Rahbar, A; Sontgerath, JS; Zitek, T, 2018) |
| "A low-dose ketamine infusion protocol provided significant pain relief with mostly mild side effects and no severe adverse events." | 7.81 | Low-Dose Ketamine Infusion for Emergency Department Patients with Severe Pain. ( Ahern, TL; Frazee, BW; Herring, AA; Miller, S, 2015) |
| "Consumption of monosodium glutamate has long been considered to precipitate headaches in susceptible patients." | 7.68 | Vasospasm contributes to monosodium glutamate-induced headache. ( Merritt, JE; Williams, PB, 1990) |
| "Secondary outcome measures are postoperative pain intensity scores, psychological parameters, length of hospital stay and adverse events and will be reassessed at 3 and 6 months after surgery, with a baseline measurement preoperatively." | 6.90 | Assessing the effectiveness of perioperative s-ketamine on new-onset headache after resective epilepsy surgery (ESPAIN-trial): protocol for a randomised, double-blind, placebo-controlled trial. ( Bastiaenen, C; Bos, M; Colon, A; Dings, J; Hoogland, G; Rijkers, K; Rouhl, RPW; Schijns, OEMG; Sloekers, JCT; Theunissen, M; van Kuijk, S, 2019) |
| "Intranasal ketamine and intravenous ketorolac both effectively reduced headaches." | 5.51 | Comparison of the efficacy of intranasal ketamine versus intravenous ketorolac on acute non-traumatic headaches: a randomized double-blind clinical trial. ( Baigrezaii, H; Meysami, A; Nazarianpirdosti, M; Safari-Faramani, R; Sarvari, HR, 2022) |
| " intranasal ketamine among ED patients with primary headache." | 5.30 | The THINK (Treatment of Headache with Intranasal Ketamine) Trial: A Randomized Controlled Trial Comparing Intranasal Ketamine with Intravenous Metoclopramide. ( April, MD; Benish, T; Casmaer, M; Hunter, CJ; Love, S; Summers, SM; Villalobos, D, 2019) |
| "The results suggested that it is possible to improve symptoms of depression earlier by using ketamine anesthesia." | 5.14 | Rapid antidepressant effect of ketamine anesthesia during electroconvulsive therapy of treatment-resistant depression: comparing ketamine and propofol anesthesia. ( Higuchi, T; Nagafusa, Y; Nakai, T; Nishikawa, T; Okamoto, N; Sakamoto, K, 2010) |
| "Subanesthetic ketamine infusion has been used for managing refractory headache in inpatient or outpatient infusion settings." | 4.31 | Real-world study of intranasal ketamine for use in patients with refractory chronic migraine: a retrospective analysis. ( Lauritsen, CG; Marmura, MJ; Natekar, A; Park, J; Viscusi, ER; Yuan, H, 2023) |
| " We present a case of SUNCT syndrome with successful pain relief by intravenous administration of ketamine, an N-methyl-D-aspartate receptor (NMDAR) antagonist." | 4.02 | Pain Relief in Short-Lasting Unilateral Neuralgiform Headache with Conjunctival inJection and Tearing Syndrome with Intravenous Ketamine: A Case Report. ( Kawabata, K; Sago, T; Shiiba, S, 2021) |
| "Intravenous subdissociative-dose ketamine has been shown to be effective for pain management, but has not been specifically studied for headaches in the emergency department (ED)." | 3.88 | A Comparison of Headache Treatment in the Emergency Department: Prochlorperazine Versus Ketamine. ( Bartlett, A; Clark, JM; Forred, W; Gates, M; Patel, J; Pitotti, C; Rahbar, A; Sontgerath, JS; Zitek, T, 2018) |
| "A low-dose ketamine infusion protocol provided significant pain relief with mostly mild side effects and no severe adverse events." | 3.81 | Low-Dose Ketamine Infusion for Emergency Department Patients with Severe Pain. ( Ahern, TL; Frazee, BW; Herring, AA; Miller, S, 2015) |
| "To describe the unusual course of postdural puncture headache (PDPH) after pump implantation for intrathecal baclofen (ITB) administration in patients with complex regional pain syndrome (CRPS)-related dystonia." | 3.75 | Postdural puncture headache in complex regional pain syndrome: a retrospective observational study. ( Delhaas, EM; Marinus, J; Munts, AG; van Hilten, JJ; Voormolen, JH, 2009) |
| "Consumption of monosodium glutamate has long been considered to precipitate headaches in susceptible patients." | 3.68 | Vasospasm contributes to monosodium glutamate-induced headache. ( Merritt, JE; Williams, PB, 1990) |
| "Secondary outcome measures are postoperative pain intensity scores, psychological parameters, length of hospital stay and adverse events and will be reassessed at 3 and 6 months after surgery, with a baseline measurement preoperatively." | 2.90 | Assessing the effectiveness of perioperative s-ketamine on new-onset headache after resective epilepsy surgery (ESPAIN-trial): protocol for a randomised, double-blind, placebo-controlled trial. ( Bastiaenen, C; Bos, M; Colon, A; Dings, J; Hoogland, G; Rijkers, K; Rouhl, RPW; Schijns, OEMG; Sloekers, JCT; Theunissen, M; van Kuijk, S, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (17.65) | 18.7374 |
| 1990's | 2 (11.76) | 18.2507 |
| 2000's | 2 (11.76) | 29.6817 |
| 2010's | 6 (35.29) | 24.3611 |
| 2020's | 4 (23.53) | 2.80 |
| Authors | Studies |
|---|---|
| Shiiba, S | 1 |
| Sago, T | 1 |
| Kawabata, K | 1 |
| Sarvari, HR | 1 |
| Baigrezaii, H | 1 |
| Nazarianpirdosti, M | 1 |
| Meysami, A | 1 |
| Safari-Faramani, R | 1 |
| Hoydonckx, Y | 1 |
| Singh, M | 1 |
| Gilron, I | 1 |
| Khan, J | 1 |
| Narouze, S | 1 |
| Dahan, A | 1 |
| Curtis, K | 1 |
| Cao, X | 1 |
| Kara, J | 1 |
| Bhatia, A | 1 |
| Yuan, H | 1 |
| Natekar, A | 1 |
| Park, J | 1 |
| Lauritsen, CG | 1 |
| Viscusi, ER | 1 |
| Marmura, MJ | 1 |
| Sloekers, JCT | 1 |
| Bos, M | 1 |
| Hoogland, G | 1 |
| Bastiaenen, C | 1 |
| van Kuijk, S | 1 |
| Theunissen, M | 1 |
| Rijkers, K | 1 |
| Dings, J | 1 |
| Colon, A | 1 |
| Rouhl, RPW | 1 |
| Schijns, OEMG | 1 |
| Zitek, T | 1 |
| Gates, M | 1 |
| Pitotti, C | 1 |
| Bartlett, A | 1 |
| Patel, J | 1 |
| Rahbar, A | 1 |
| Forred, W | 1 |
| Sontgerath, JS | 1 |
| Clark, JM | 1 |
| Benish, T | 1 |
| Villalobos, D | 1 |
| Love, S | 1 |
| Casmaer, M | 1 |
| Hunter, CJ | 1 |
| Summers, SM | 1 |
| April, MD | 1 |
| Goodnough, R | 1 |
| Ahern, TL | 1 |
| Herring, AA | 1 |
| Miller, S | 1 |
| Frazee, BW | 1 |
| Munts, AG | 1 |
| Voormolen, JH | 1 |
| Marinus, J | 1 |
| Delhaas, EM | 1 |
| van Hilten, JJ | 1 |
| Okamoto, N | 1 |
| Nakai, T | 1 |
| Sakamoto, K | 1 |
| Nagafusa, Y | 1 |
| Higuchi, T | 1 |
| Nishikawa, T | 1 |
| Sparks, CJ | 1 |
| Perndt, H | 1 |
| Agiomea, K | 1 |
| Fa'arondo, J | 1 |
| Roberts, LJ | 1 |
| Goucke, CR | 1 |
| Hejja, P | 1 |
| Galloon, S | 1 |
| Merritt, JE | 1 |
| Williams, PB | 1 |
| Ghoneim, MM | 1 |
| Hinrichs, JV | 1 |
| Mewaldt, SP | 1 |
| Petersen, RC | 1 |
| Fiorani, V | 1 |
| Petterino, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The CHECK Trial: A Comparison of Headache Treatment in the Emergency Department: Compazine Versus Ketamine. A Multi-Center, Randomized, Double-Blind, Clinical Control Trial[NCT02735343] | Phase 3 | 5 participants (Actual) | Interventional | 2016-08-31 | Terminated (stopped due to only recruited 5 patients at this location) | ||
| A Combination Study With Sub-Dissociative Ketamine and Fentanyl to Treat Moderate to Severe Pain in the Emergency Department[NCT03959852] | Phase 4 | 6 participants (Actual) | Interventional | 2019-11-18 | Terminated (stopped due to Residency completed.) | ||
| Comparison of Intravenous Push Dose of Low Dose Ketamine to Short Infusion of Low Dose Ketamine for Treatment of Moderate to Severe Pain in the Emergency Department: A Prospective, Randomized, Double-Blind Study[NCT02363270] | 48 participants (Actual) | Interventional | 2015-04-01 | Completed | |||
| Intraoperative Low-dose Ketamine Infusion as the Main Analgesic in Burn Patients[NCT03049930] | Phase 4 | 46 participants (Anticipated) | Interventional | 2018-02-27 | Recruiting | ||
| Low-Dose Ketamine Versus Morphine for Moderate to Severe Pain in the Emergency Department Geriatric Population: A Prospective, Randomized, Double-Blind Study.[NCT02673372] | Phase 4 | 60 participants (Actual) | Interventional | 2016-04-30 | Completed | ||
| A Prospective Randomized Double Blinded Control Trial Using Ketamine or Propofol Anesthesia for Electroconvulsive Therapy: Improving Treatment-Resistant Depression[NCT01935115] | Phase 4 | 27 participants (Actual) | Interventional | 2013-09-30 | Completed | ||
| Effects of Low-dose Ketamine as an Adjunct to Propofol-based Anesthesia for Electroconvulsive Therapy[NCT02579642] | Phase 4 | 48 participants (Actual) | Interventional | 2015-10-31 | Completed | ||
| Comparing Therapeutic Efficacy and Cognitive Side Effects of Electroconvulsive Therapy (ECT) Using Ketamine Versus Methohexital Anesthesia[NCT01881763] | Phase 4 | 31 participants (Actual) | Interventional | 2010-06-30 | Completed | ||
| Intravenous Ketamine for Pain Control During First Trimester Surgical Abortion[NCT03751423] | Phase 3 | 123 participants (Anticipated) | Interventional | 2019-06-10 | Suspended (stopped due to Study on-hold due to COVID-19 pandemic restrictions. Will resume when possible.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Overall rate of feeling of unreality as measured by Side Effects Rating Scale for Dissociative Anesthetics (SERSDA) (NCT02363270)
Timeframe: 30 minutes
| Intervention | Participants (Count of Participants) |
|---|---|
| IV Push Group | 22 |
| IV Drip Group | 13 |
The primary outcome will be the comparative reduction of NRS pain scores between the 2 groups at 30 minutes. The NRS Pain scale ranges from 0 to 10 (0 being no pain at all to 10 being very severe pain; 5 is moderate pain) (NCT02673372)
Timeframe: 30 minutes
| Intervention | score on a scale (Mean) |
|---|---|
| Morphine Group | 4.4 |
| Ketamine Group | 4.2 |
The items mostly range from a score of 0-4 but there are some questions that range from a score of 0-2. The maximum total score that can be reported is 76 and the lowest score is 0. Higher values represent a worse outcome. Items are summed together to compute the total score. Remission is defined as two consecutive Hamilton Rating Scale for Depression, 24 items (HRSD-24) scores < 10, and HRSD-24 total score does not increase > 3 points on the second consecutive HRSD-24, or remains < 6 at the last two consecutive treatments. HRSD-24 scores are used to define remission. (NCT01881763)
Timeframe: Days required to achieve remission (on average 3-4 weeks)
| Intervention | HRSD units (Mean) |
|---|---|
| Ketamine | 7.82 |
| Methohexital | 8.60 |
7 trials available for ketamine and Bilateral Headache
| Article | Year |
|---|---|
Comparison of the efficacy of intranasal ketamine versus intravenous ketorolac on acute non-traumatic headaches: a randomized double-blind clinical trial.
Topics: Administration, Intranasal; Analgesics; Double-Blind Method; Headache; Humans; Ketamine; Ketorolac | 2022 |
Trial protocol for a multicenter randomized controlled trial to assess the efficacy and safety of intravenous ketamine for chronic daily headaches: the "KetHead" trial.
Topics: Adult; Headache; Headache Disorders; Humans; Ketamine; Multicenter Studies as Topic; N-Methylasparta | 2023 |
Assessing the effectiveness of perioperative s-ketamine on new-onset headache after resective epilepsy surgery (ESPAIN-trial): protocol for a randomised, double-blind, placebo-controlled trial.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Double-Blind Method; Drug Combinations; | 2019 |
The THINK (Treatment of Headache with Intranasal Ketamine) Trial: A Randomized Controlled Trial Comparing Intranasal Ketamine with Intravenous Metoclopramide.
Topics: Academic Medical Centers; Administration, Intranasal; Adult; Analgesics; Diphenhydramine; Emergency | 2019 |
Rapid antidepressant effect of ketamine anesthesia during electroconvulsive therapy of treatment-resistant depression: comparing ketamine and propofol anesthesia.
Topics: Anesthetics; Antidepressive Agents; Depression; Electroconvulsive Therapy; Female; Headache; Humans; | 2010 |
Rapid antidepressant effect of ketamine anesthesia during electroconvulsive therapy of treatment-resistant depression: comparing ketamine and propofol anesthesia.
Topics: Anesthetics; Antidepressive Agents; Depression; Electroconvulsive Therapy; Female; Headache; Humans; | 2010 |
Rapid antidepressant effect of ketamine anesthesia during electroconvulsive therapy of treatment-resistant depression: comparing ketamine and propofol anesthesia.
Topics: Anesthetics; Antidepressive Agents; Depression; Electroconvulsive Therapy; Female; Headache; Humans; | 2010 |
Rapid antidepressant effect of ketamine anesthesia during electroconvulsive therapy of treatment-resistant depression: comparing ketamine and propofol anesthesia.
Topics: Anesthetics; Antidepressive Agents; Depression; Electroconvulsive Therapy; Female; Headache; Humans; | 2010 |
Rapid antidepressant effect of ketamine anesthesia during electroconvulsive therapy of treatment-resistant depression: comparing ketamine and propofol anesthesia.
Topics: Anesthetics; Antidepressive Agents; Depression; Electroconvulsive Therapy; Female; Headache; Humans; | 2010 |
Rapid antidepressant effect of ketamine anesthesia during electroconvulsive therapy of treatment-resistant depression: comparing ketamine and propofol anesthesia.
Topics: Anesthetics; Antidepressive Agents; Depression; Electroconvulsive Therapy; Female; Headache; Humans; | 2010 |
Rapid antidepressant effect of ketamine anesthesia during electroconvulsive therapy of treatment-resistant depression: comparing ketamine and propofol anesthesia.
Topics: Anesthetics; Antidepressive Agents; Depression; Electroconvulsive Therapy; Female; Headache; Humans; | 2010 |
Rapid antidepressant effect of ketamine anesthesia during electroconvulsive therapy of treatment-resistant depression: comparing ketamine and propofol anesthesia.
Topics: Anesthetics; Antidepressive Agents; Depression; Electroconvulsive Therapy; Female; Headache; Humans; | 2010 |
Rapid antidepressant effect of ketamine anesthesia during electroconvulsive therapy of treatment-resistant depression: comparing ketamine and propofol anesthesia.
Topics: Anesthetics; Antidepressive Agents; Depression; Electroconvulsive Therapy; Female; Headache; Humans; | 2010 |
A consideration of ketamine dreams.
Topics: Anesthesia, Intravenous; Consciousness; Dilatation and Curettage; Dreams; Headache; Humans; Ketamine | 1975 |
Ketamine: behavioral effects of subanesthetic doses.
Topics: Adolescent; Adult; Affect; Female; Headache; Humans; Ketamine; Learning; Male; Memory; Mental Disord | 1985 |
10 other studies available for ketamine and Bilateral Headache
| Article | Year |
|---|---|
Pain Relief in Short-Lasting Unilateral Neuralgiform Headache with Conjunctival inJection and Tearing Syndrome with Intravenous Ketamine: A Case Report.
Topics: Administration, Intravenous; Blepharoptosis; Headache; Humans; Ketamine; Male; Middle Aged; SUNCT Sy | 2021 |
Real-world study of intranasal ketamine for use in patients with refractory chronic migraine: a retrospective analysis.
Topics: Adult; Analgesics; Female; Headache; Humans; Ketamine; Male; Migraine Disorders; Prospective Studies | 2023 |
A Comparison of Headache Treatment in the Emergency Department: Prochlorperazine Versus Ketamine.
Topics: Adolescent; Adult; Aged; Anesthetics, Dissociative; Dopamine Antagonists; Dose-Response Relationship | 2018 |
THINK of Ketamine for Headache.
Topics: Administration, Intravenous; Analgesics; Headache; Humans; Ketamine; Metoclopramide | 2019 |
Low-Dose Ketamine Infusion for Emergency Department Patients with Severe Pain.
Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Blood Pressure; Dizziness; Dose-Response Relationship, | 2015 |
Low-Dose Ketamine Infusion for Emergency Department Patients with Severe Pain.
Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Blood Pressure; Dizziness; Dose-Response Relationship, | 2015 |
Low-Dose Ketamine Infusion for Emergency Department Patients with Severe Pain.
Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Blood Pressure; Dizziness; Dose-Response Relationship, | 2015 |
Low-Dose Ketamine Infusion for Emergency Department Patients with Severe Pain.
Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Blood Pressure; Dizziness; Dose-Response Relationship, | 2015 |
Low-Dose Ketamine Infusion for Emergency Department Patients with Severe Pain.
Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Blood Pressure; Dizziness; Dose-Response Relationship, | 2015 |
Low-Dose Ketamine Infusion for Emergency Department Patients with Severe Pain.
Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Blood Pressure; Dizziness; Dose-Response Relationship, | 2015 |
Low-Dose Ketamine Infusion for Emergency Department Patients with Severe Pain.
Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Blood Pressure; Dizziness; Dose-Response Relationship, | 2015 |
Low-Dose Ketamine Infusion for Emergency Department Patients with Severe Pain.
Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Blood Pressure; Dizziness; Dose-Response Relationship, | 2015 |
Low-Dose Ketamine Infusion for Emergency Department Patients with Severe Pain.
Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Blood Pressure; Dizziness; Dose-Response Relationship, | 2015 |
Low-Dose Ketamine Infusion for Emergency Department Patients with Severe Pain.
Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Blood Pressure; Dizziness; Dose-Response Relationship, | 2015 |
Low-Dose Ketamine Infusion for Emergency Department Patients with Severe Pain.
Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Blood Pressure; Dizziness; Dose-Response Relationship, | 2015 |
Low-Dose Ketamine Infusion for Emergency Department Patients with Severe Pain.
Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Blood Pressure; Dizziness; Dose-Response Relationship, | 2015 |
Low-Dose Ketamine Infusion for Emergency Department Patients with Severe Pain.
Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Blood Pressure; Dizziness; Dose-Response Relationship, | 2015 |
Low-Dose Ketamine Infusion for Emergency Department Patients with Severe Pain.
Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Blood Pressure; Dizziness; Dose-Response Relationship, | 2015 |
Low-Dose Ketamine Infusion for Emergency Department Patients with Severe Pain.
Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Blood Pressure; Dizziness; Dose-Response Relationship, | 2015 |
Low-Dose Ketamine Infusion for Emergency Department Patients with Severe Pain.
Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Blood Pressure; Dizziness; Dose-Response Relationship, | 2015 |
Postdural puncture headache in complex regional pain syndrome: a retrospective observational study.
Topics: Adolescent; Adult; Anesthetics, Dissociative; Baclofen; Blood Patch, Epidural; Causality; Cerebrospi | 2009 |
Spinal anaesthesia for caesarean section in the Solomon Islands.
Topics: Anesthesia, General; Anesthesia, Obstetrical; Anesthesia, Spinal; Bupivacaine; Cesarean Section; Fem | 1994 |
Retro-orbital tumour--an uncommon cause of headache in pregnancy.
Topics: Adult; Amitriptyline; Analgesics, Non-Narcotic; Analgesics, Opioid; Female; Headache; Hemangioma, Ca | 2001 |
Vasospasm contributes to monosodium glutamate-induced headache.
Topics: Animals; Aorta; Dose-Response Relationship, Drug; Female; Headache; Ketamine; Rabbits; Sodium Glutam | 1990 |
[Ketamine in instrumental studies and in endoscopic treatment].
Topics: Anesthetics, Dissociative; Angiography; Bronchography; Bronchoscopy; Cerebral Angiography; Endoscopy | 1974 |