Page last updated: 2024-10-29

ketamine and Ache

ketamine has been researched along with Ache in 598 studies

Ketamine: A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.
ketamine : A member of the class of cyclohexanones in which one of the hydrogens at position 2 is substituted by a 2-chlorophenyl group, while the other is substituted by a methylamino group.

Research Excerpts

ExcerptRelevanceReference
"This work focused on functional connectivity changes under midazolam and ketamine sedation during performance of a memory task, with the periodic experience of pain."9.69Brain connectivity under light sedation with midazolam and ketamine during task performance and the periodic experience of pain: Examining concordance between different approaches for seed-based connectivity analysis. ( Aizenstein, HJ; Burlew, AC; Fiez, JA; Ibinson, JW; Smith, CT; Vogt, KM, 2023)
"To investigate if intravenous fentanyl or intravenous ketamine can provide adequate analgesia in preterm infants undergoing laser photocoagulation for retinopathy of prematurity (ROP)."9.41'NOPAIN-ROP' trial: Intravenous fentanyl and intravenous ketamine for pain relief during laser photocoagulation for retinopathy of prematurity (ROP) in preterm infants: A randomised trial. ( Agarwal, R; Chandra, P; Deorari, A; Madathil, S; Sankar, MJ; Thomas, D; Thukral, A, 2021)
"Painful stimulation during light sedation with midazolam, but not ketamine, can be accompanied by increased coherence in brain connectivity, even though details are less likely to be recollected as explicit memories."9.41Midazolam and Ketamine Produce Distinct Neural Changes in Memory, Pain, and Fear Networks during Pain. ( Aizenstein, HJ; Citro, AT; Fiez, JA; Ibinson, JW; Karim, HT; Mahajan, A; Norton, CM; Popov, V; Reder, LM; Smith, CT; Vogt, KM, 2021)
"This study aimed to compare analgesic efficacy of intranasal (IN) ketamine to IN fentanyl for moderate to severe pain in children in a pediatric emergency department."9.41Analgesic Efficacy of Intranasal Ketamine Versus Intranasal Fentanyl for Moderate to Severe Pain in Children: A Prospective, Randomized, Double-Blind Study. ( Brady, J; Chitnis, SS; Drapkin, J; Fromm, C; Kriss, S; Likourezos, A; Motov, S; Pushkar, I; Quinn, K; Yasavolian, M, 2021)
"To determine whether intranasal ketamine is noninferior to intranasal fentanyl for pain reduction in children presenting with acute extremity injuries."9.30Effect of Intranasal Ketamine vs Fentanyl on Pain Reduction for Extremity Injuries in Children: The PRIME Randomized Clinical Trial. ( Caruso, M; Florin, TA; Frey, TM; Mittiga, MR; Zhang, N; Zhang, Y, 2019)
" This study aims to evaluate the efficacy and safety of subdissociative intranasal ketamine as a cheap, readily available and easily administered adjunct to standard pain therapy."9.24Subdissociative intranasal ketamine plus standard pain therapy versus standard pain therapy in the treatment of paediatric sickle cell disease vaso-occlusive crises in resource-limited settings: study protocol for a randomised controlled trial. ( Helm, E; Mfinanga, JA; Moore, CG; Nshom, E; Reynolds, SL; Runyon, MS; Sawe, HR; Young, JR, 2017)
" Ketamine mouthwashes have been used for pain relief, but supporting evidence is limited."9.24Treatment of severe mucositis pain with oral ketamine mouthwash. ( Craig, M; Cumpston, A; Hamadani, M; Kanate, AS; Shillingburg, A; Wen, S, 2017)
"The 3 study groups showed a highly significant, similar maximal pain reduction of 56 ± 26 mm for IN Ketamine, and 59 ± 22 and 48 ± 30 for IV MO and IM MO, respectively."9.22Intranasal ketamine for acute traumatic pain in the Emergency Department: a prospective, randomized clinical trial of efficacy and safety. ( Gigi, R; Halpern, P; Nadav, D; Rozenek, M; Sarig-Meth, T; Shapira, A; Shimonovich, S; West, D, 2016)
"This study was a long-term follow-up study of the prehospital, prospective, randomised, controlled, open-label study comparing ketamine with morphine in patients with trauma and a verbal pain score of >5 after 5 mg intravenous morphine."9.19Long-term pain prevalence and health-related quality of life outcomes for patients enrolled in a ketamine versus morphine for prehospital traumatic pain randomised controlled trial. ( Bernard, S; Cameron, P; Fitzgerald, M; Jennings, PA; Jolley, D; Masci, K; Walker, T, 2014)
"Ketamine can completely eliminate pain associated with propofol injection."9.17An effective dose of ketamine for eliminating pain during injection of propofol: a dose response study. ( Wang, M; Wang, Q; Wang, WS; Yu, YY, 2013)
"The lidocaine-ketamine combination is most effective for decreasing the pain on propofol injection."9.17A prospective, randomized, double-blind study to compare the efficacy of lidocaine + metoclopramide and lidocaine + ketamine combinations in preventing pain on propofol injection. ( Chaudhary, K; Gogia, AR; Gupta, P, 2013)
"To investigate the effects of ketamine hydrochloride on the analgesic effects of tramadol hydrochloride in horses with signs of pain associated with naturally occurring chronic laminitis."9.16Effect of ketamine hydrochloride on the analgesic effects of tramadol hydrochloride in horses with signs of chronic laminitis-associated pain. ( Guedes, AG; Hood, DM; Matthews, NS, 2012)
"To evaluate the efficacy of ketamine in preventing propofol injection pain in children."9.16Prevention of propofol-induced pain in children: pretreatment with small doses of ketamine. ( Bao, SM; Guo, Y; Meng, LX; Zhang, LH; Zhao, GY, 2012)
"02 mg, % 2 lidocaine 40 mg, metoclopramide 10 mg, and ketamine 100 microg/kg yields propofol induced pain 38%, 76%, 76%, and 58% respectively."9.16The effects of remifentanil, lidocaine, metoclopramide, or ketamine pretreatment on propofol injection pain. ( Aktay, M; Ozlü, O; Polat, R, 2012)
"Long-term S(+)-ketamine treatment is effective in causing pain relief in CRPS-1 patients with analgesia outlasting the treatment period by 50 days."9.15Population pharmacokinetic-pharmacodynamic modeling of ketamine-induced pain relief of chronic pain. ( Aarts, L; Bauer, M; Dahan, A; Niesters, M; Noppers, I; Olofsen, E; Sarton, E; Sigtermans, M, 2011)
"The purpose of this study was to evaluate differences in pain intensity, pain quality, physiological measures, and adverse effects when patients received morphine with saline (MS) compared with morphine and a small dose of ketamine (MK) before an open wound care procedure (WCP)."9.15Efficacy of small doses of ketamine with morphine to decrease procedural pain responses during open wound care. ( Arroyo-Novoa, CM; Figueroa-Ramos, MI; Miaskowski, C; Padilla, G; Paul, SM; Puntillo, KA; Rodríguez-Ortiz, P; Stotts, NA, 2011)
"To assess the analgesic efficacy of the N-methyl-D-aspartate receptor antagonist S(+)-ketamine on fibromyalgia pain, the authors performed a randomized double blind, active placebo-controlled trial."9.15Absence of long-term analgesic effect from a short-term S-ketamine infusion on fibromyalgia pain: a randomized, prospective, double blind, active placebo-controlled trial. ( Aarts, L; Bauer, M; Dahan, A; Geleijnse, N; Mooren, R; Niesters, M; Noppers, I; Sarton, E; Swartjes, M, 2011)
"Sixteen patients with neuropathic pain of various origins were randomized into two treatment groups: (S)-ketamine 0."9.14Effects of low-dose intranasal (S)-ketamine in patients with neuropathic pain. ( Azad, SC; Beyer, A; Huge, V; Lauchart, M; Magerl, W; Schelling, G; Thieme, D, 2010)
"Administration of ketamine 100 microg x kg(-1) immediately before propofol injection is a safe and effective method in preventing propofol injection pain."9.14Prevention of propofol injection pain with small-dose ketamine. ( Nikooseresht, M; Seifrabie, M; Zahedi, H, 2009)
"5 mg kg(-1) ketamine reduced the incidence and intensity of propofol injection pain, whereas 1."9.14Ketamine eliminates propofol pain but does not affect hemodynamics during induction with double-lumen tubes. ( Furuya, H; Inoue, S; Iwata, M; Kawaguchi, M; Kimura, T; Taniguchi, S; Tojo, T, 2010)
"A study involving the use of a mixture of ketamine and midazolam delivered via patient-controlled analgesia (PCA) device was trialed to assess its effectiveness in reducing pain associated with repeated burns dressings in an adult population."9.13Ketamine and midazolam delivered by patient-controlled analgesia in relieving pain associated with burns dressings. ( MacPherson, RD; Penfold, J; Woods, D, 2008)
"This open-label trial suggests benefit in pain reduction, associated CRPS symptoms, improved quality of life and ability to work following anesthetic ketamine in previously refractory CRPS patients."9.13Efficacy of ketamine in anesthetic dosage for the treatment of refractory complex regional pain syndrome: an open-label phase II study. ( Altemeyer, KH; Dieterich, HJ; Grothusen, J; Kiefer, RT; Koffler, S; Ploppa, A; Rohr, P; Schwartzman, RJ; Unertl, K, 2008)
"Ketamine, but not calcitonin, reduced phantom limb pain."9.13Chronic phantom limb pain: the effects of calcitonin, ketamine, and their combination on pain and sensory thresholds. ( Arendt-Nielsen, L; Björgo, S; Curatolo, M; Eichenberger, U; Neff, F; Petersen-Felix, S; Sveticic, G, 2008)
"The comparison of ketamine with fentanyl for pain control of pediatric orthopedic emergencies remains controversial."9.12Influence of ketamine versus fentanyl on pain relief for pediatric orthopedic emergencies: A meta-analysis of randomized controlled studies. ( Qiu, J; Xie, M, 2021)
"Ketamine significantly reduced ongoing pain and evoked pain to brush and pinprick, whereas lidocaine only reduced evoked pain to repetitive pinprick stimuli."9.12Differential effect of ketamine and lidocaine on spontaneous and mechanical evoked pain in patients with nerve injury pain. ( Bach, FW; Gottrup, H; Jensen, TS; Juhl, G, 2006)
"Little is known about the effects of low-dose S-(+)-ketamine on the cerebral processing of pain."9.12Imaging pain modulation by subanesthetic S-(+)-ketamine. ( Freynhagen, R; Kochs, EF; Sprenger, T; Tölle, TR; Valet, M; Wagner, KJ; Woltmann, R; Zimmer, C, 2006)
"Administration of ketamine 100 microg/kg immediately before propofol injection provided the optimal dose and timing to reduce propofol-induced pain on injection."9.12Small-dose ketamine reduces the pain of propofol injection. ( Cho, SJ; Ham, KD; Hwang, JH; Kim, YK; Koo, SW, 2006)
"The aim of the study was to compare in emergency settings 2 analgesic regimens, morphine with ketamine (K group) or morphine with placebo (P group), for severe acute pain in trauma patients."9.12Management of severe acute pain in emergency settings: ketamine reduces morphine consumption. ( Adnet, F; Catineau, J; Combes, X; Dolveck, F; Galinski, M; Lapostolle, F; Limoges, V; Pommier, V; Smaïl, N; Templier, F, 2007)
"Injection pain was twice as common with ketamine-propofol admixture than with lidocaine-propofol admixture."9.12A ketamine-propofol admixture does not reduce the pain on injection compared with a lidocaine-propofol admixture. ( Abdelaziz, AB; Cherif, R; Chettaoui, O; Kaabachi, O; Kokki, H; Ouezini, R, 2007)
"Propofol, a commonly used anesthetic, often causes pain on injection."9.12Painless injection of propofol: pretreatment with ketamine vs thiopental, meperidine, and lidocaine. ( Boker, A; Ertok, E; Saadawy, I, 2007)
"The aim of this study was to determine whether the follow-up of pain processing recovery in hyperalgesic fibromyalgia (FM) could be objectively evaluated with brain perfusion ethyl cysteinate dimer single photon computerized tomography (ECD-SPECT) after administration of ketamine."9.12Follow-up of pain processing recovery after ketamine in hyperalgesic fibromyalgia patients using brain perfusion ECD-SPECT. ( Cammilleri, S; Colavolpe, C; de Laforte, C; Guedj, E; Mundler, O; Niboyet, J, 2007)
"Ketamine but not lidocaine showed a significant analgesic effect in patients with neuropathic pain after spinal cord injury."9.11The analgesic effect of intravenous ketamine and lidocaine on pain after spinal cord injury. ( Gordh, T; Karlsten, R; Kvarnström, A; Quiding, H, 2004)
"This is the first experimental study in humans to find synergistic analgesic effects with coadministration of the N-methyl-D-aspartate receptor antagonist ketamine and morphine on pain involving central sensitization phenomena."9.11The synergistic effect of combined treatment with systemic ketamine and morphine on experimentally induced windup-like pain in humans. ( Schulte, H; Segerdahl, M; Sollevi, A, 2004)
"Small-dose of ketamine does not seem to be a useful adjunct to remifentanil-based anaesthesia during short, painful surgical procedures."9.11Ketamine does not decrease postoperative pain after remifentanil-based anaesthesia for tonsillectomy in adults. ( Lebrun, T; Polin, B; Sandefo, I; Van Elstraete, AC, 2004)
"Conscious sedation with rectally applied S(+)-ketamine and Midazolam allows safe and painless dressing changes after heat injuries in children."9.11Conscious sedation: Off-label use of rectal S(+)-ketamine and midazolam for wound dressing changes in paediatric heat injuries. ( Heinrich, M; Muensterer, OJ; Till, H; Wetzstein, V, 2004)
" Fentanyl also may reduce the pain of diazepam injection by blocking the opiate receptors in vessels walls."9.11The effect of ketamine and fentanyl in reducing the pain of diazepam injection. ( Azemati, M; Azemati, S; Khosravi, A; Khosravi, MB, 2004)
") ketamine sedation administered by nonanesthetist physicians for painful procedures."9.11Intravenous ketamine sedation for painful oncology procedures. ( Barbour, K; Evans, D; Kobe, J; Montgomery, CJ; Rogers, P; Turnham, L; Vandebeek, C; Wilson, L, 2005)
"This prospective, double-blind, randomized, placebo-controlled study compares the effects of ephedrine and ketamine on injection pain, and hypotension from propofol."9.11Comparison of ephedrine and ketamine in prevention of injection pain and hypotension due to propofol induction. ( Altunkaya, H; Ayoğlu, H; Ciçek, E; Demirel, CB; Ozer, Y; Ozkoçak, I, 2005)
"We evaluated whether preadministration of low-dose ketamine could attenuate tourniquet pain and arterial pressure increase using high tourniquet pressure in ten healthy awake volunteers."9.11Preadministration of low-dose ketamine reduces tourniquet pain in healthy volunteers. ( Fukusaki, M; Kanaide, M; Matsumoto, S; Sumikawa, K; Takada, M; Terao, Y; Yamashita, K, 2005)
"A double-blind, randomized, placebo-controlled 3-week study evaluated the efficacy of topical 2% amitriptyline, 1% ketamine, and a combination of both in treating patients with neuropathic pain."9.11Topical 2% amitriptyline and 1% ketamine in neuropathic pain syndromes: a randomized, double-blind, placebo-controlled trial. ( Clark, AJ; Lynch, ME; Sawynok, J; Sullivan, MJ, 2005)
"The aim of the present study was to clarify the neurophysiological changes associated with analgesic and behavioral effects of low-dose ketamine HCl in patients suffering from chronic neuropathic pain."9.10Effects of low-dose ketamine on neuropathic pain: An electroencephalogram-electrooculogram/behavioral study. ( Kato, J; Kojima, T; Matsuura, M; Nagashima, M; Oga, K; Ogawa, S; Saeki, S, 2002)
"The incidence of pain of the infusion was significantly lower in patients pretreated with ketamine (8% vs 37%, P = 0."9.10Pretreatment with intravenous ketamine reduces propofol injection pain. ( Barbi, E; Gagliardo, A; Gerarduzzi, T; Marchetti, F; Neri, E; Sarti, A; Ventura, A, 2003)
"The purpose of this study was to evaluate the effect of pre-treatment with ketamine on the reduction of pain during injection of propofol in adult patients."9.10[Pre-treatment with ketamine reduces incidence and severity of pain on propofol injection]. ( Kumazawa, T; Masamune, T; Nonaka, A; Suzuki, S, 2002)
"The aim of this study was to assess the efficacy of dextromethorphan and ketamine relative to placebo on the acute nociceptive threshold and wind-up of second pain response in healthy male volunteers."9.10Assessment of the effect of dextromethorphan and ketamine on the acute nociceptive threshold and wind-up of the second pain response in healthy male volunteers. ( Fisher, G; Growcott, JW; Hughes, AM; Rhodes, J; Sellers, M, 2002)
"We examined the role of N-methyl-D-aspartate (NMDA) receptors in chronic (pathological) pain in humans by using the NMDA receptor antagonist ketamine as a probe."9.09Prolonged analgesic effect of ketamine, an N-methyl-D-aspartate receptor inhibitor, in patients with chronic pain. ( Oye, I; Rabben, T; Skjelbred, P, 1999)
"Anecdotal reports suggest that the general anaesthetic drug ketamine, taken orally in low doses, can give rise to some extra analgesia in patients with refractory neuropathic pain."9.09N of 1 randomised controlled trials of oral ketamine in patients with chronic pain. ( Gaines, SP; Haines, DR, 1999)
" We showed that, as in animals, this phenomenon, which might represent an elementary form of the central sensitization involved in various painful syndromes, depends on the activation of N-methyl-D-aspartate receptors, because it was selectively reduced after the administration of ketamine."9.09The effects of ketamine on the temporal summation (wind-up) of the R(III) nociceptive flexion reflex and pain in humans. ( Bouhassira, D; Brasseur, L; Chauvin, M; Dupont, X; Guirimand, F, 2000)
"To assess the suitability of ketamine for relief of pain caused by tracheal suction during ventilator treatment in newborn infants."9.09Ketamine for procedural pain relief in newborn infants. ( Fellman, V; Huttunen, P; Neuvonen, PJ; Saarenmaa, E, 2001)
"Pain intensity, muscle strength, static muscle endurance, pressure pain threshold, and pain tolerance at tender points and control points were assessed in 31 patients with fibromyalgia (FM), before and after intravenous administration of morphine (9 patients), lidocaine (11 patients), and ketamine (11 patients)."9.08Pain analysis in patients with fibromyalgia. Effects of intravenous morphine, lidocaine, and ketamine. ( Bäckman, E; Bengtsson, A; Bengtsson, M; Henriksson, KG; Sörensen, J, 1995)
" A few small studies in patients have suggested that intravenous boluses or rapid infusions of the N-methyl-D-aspartate (NMDA) antagonist ketamine relieve some neuropathic pains but also produce disturbances of cognition and mood."9.08Intravenous infusion of the NMDA antagonist, ketamine, in chronic posttraumatic pain with allodynia: a double-blind comparison to alfentanil and placebo. ( Bennett, GJ; Byas-Smith, MG; Gracely, RH; Max, MB, 1995)
"Ketamine has been administered epidurally and intrathecally for operative and post-operative pain control."9.08Intrathecal ketamine reduces morphine requirements in patients with terminal cancer pain. ( Chang, JY; Ho, ST; Wong, CS; Yang, CY, 1996)
"Ten patients (4 female, 6 male) aged 34-67 years suffering from peripheral neuropathic pain participated in a double-blind placebo-controlled study where ketamine or magnesium chloride were administered by a 10 min bolus infusion (ketamine: 0."9.08NMDA receptor blockade in chronic neuropathic pain: a comparison of ketamine and magnesium chloride. ( Arendt-Nielsen, L; Felsby, S; Jensen, TS; Nielsen, J, 1996)
"Ketamine-a clinical available NMDA receptor antagonist-was administered intravenously to a patient with established stump pain in a double-blind saline-controlled fashion."9.08Oral ketamine therapy in the treatment of postamputation stump pain. ( Hansen, PO; Jensen, TS; Nikolajsen, L, 1997)
"9% saline (1 ml) on propofol injection pain."9.08The effect of ketamine pretreatment on propofol injection pain in 100 women. ( Kua, SW; Onsiong, MK; Tan, CH, 1998)
" This study examined the analgesic effect of local ketamine infiltration, compared with placebo and systemic ketamine, in a human model of inflammatory pain."9.08Peripheral analgesic effects of ketamine in acute inflammatory pain. ( Galle, TS; Kehlet, H; Pedersen, JL, 1998)
"Ketamine in sub-dissociative doses has been shown to have analgesic effects in various pain conditions, including neuropathic and phantom-limb pain, where conventional treatment has often failed."9.08The analgesic effect of racemic ketamine in patients with chronic ischemic pain due to lower extremity arteriosclerosis obliterans. ( Gustafsson, LL; Hasselström, J; Heller, A; Persson, J; Svensson, JO; Wiklund, B, 1998)
"The analgesic efficiency of ketamine and pethidine was compared in experimental ischemic pain and postoperative pain after oral surgery."9.06Comparison of ketamine and pethidine in experimental and postoperative pain. ( Hustveit, O; Maurset, A; Skoglund, LA; Øye, I, 1989)
"Intravenous ketamine is commonly used for pain management in the civilian prehospital setting."9.05Use of ketamine for prehospital pain control on the battlefield: A systematic review. ( Cauet, A; de Rocquigny, G; Dubecq, C; Martinez, T; Pasquier, P; Peffer, J; Travers, S, 2020)
"Ketamine is regaining popularity in the field of anesthesia and beyond."9.05Ketamine: a versatile tool for anesthesia and analgesia. ( Barrett, W; Buxhoeveden, M; Dhillon, S, 2020)
"Low-dose ketamine infusions for pediatric patients with sickle cell disease painful crises resulted in improved pain scores and reduced opioid usage."9.01Ketamine Infusion for Pain Control in Acute Pediatric Sickle Cell Painful Crises. ( Hagedorn, JM; Monico, EC, 2019)
" All randomized controlled trials that using lidocaine for propofol injection pain in children were enrolled."8.95Efficacy of lidocaine on preventing incidence and severity of pain associated with propofol using in pediatric patients: A PRISMA-compliant meta-analysis of randomized controlled trials. ( Fu, YZ; Lang, BC; Yang, CS; Zhang, LL; Zhang, WS, 2017)
"This article reports a rare case of the use of low-dose ketamine infusion as an adjuvant to opioids to treat pain in sickle cell disease."8.90Ketamine infusion for sickle cell pain crisis refractory to opioids: a case report and review of literature. ( Baber, A; Foy, M; Uprety, D, 2014)
"The role of ketamine anesthesia in the prehospital, emergency department and operating theater settings is not well defined."8.89Ketamine: use in anesthesia. ( Andolfatto, G; Brandner, B; Ellerton, J; Marland, S; Paal, P; Strapazzon, G; Thomassen, O; Weatherall, A, 2013)
"For ketamine's fiftieth birthday, a narrative review of this unique drug in pain management is presented."8.89Ketamine in pain management. ( Persson, J, 2013)
" Ketamine is a commonly used anaesthetic agent, and in subanaesthetic doses is also given as an adjuvant to opioids for the treatment of cancer pain, particularly when opioids alone prove to be ineffective."8.88Ketamine as an adjuvant to opioids for cancer pain. ( Bell, RF; Eccleston, C; Kalso, EA, 2012)
"While most studies on intravenous ketamine show acute analgesic effects, three recent trials on long-term ketamine treatment (days to weeks) demonstrate the effectiveness of ketamine in causing long-term (months) relief of chronic pain."8.86Ketamine for the treatment of chronic non-cancer pain. ( Aarts, L; Dahan, A; Niesters, M; Noppers, I; Sarton, E; Smith, T, 2010)
"Ketamine is a commonly used anaesthetic agent, and in subanaesthetic doses is also given as an adjuvant to opioids for the treatment of cancer pain, particularly when opioids alone prove to be ineffective."8.82Ketamine as an adjuvant to opioids for cancer pain. ( Bell, R; Eccleston, C; Kalso, E, 2003)
"Ketamine is increasingly being used as an adjuvant to opioids in the treatment of refractory cancer pain."8.82Ketamine as adjuvant to opioids for cancer pain. A qualitative systematic review. ( Bell, RF; Eccleston, C; Kalso, E, 2003)
"Ketamine has diverse effects that may be of relevance to chronic pain including: N-methyl-D-aspartic acid, alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid, kainate, gamma-aminobutyric acid(A) receptors; inhibition of voltage gated Na(+) and K(+) channels and serotonin, dopamine re-uptake."8.82Ketamine in chronic pain management: an evidence-based review. ( Cousins, MJ; Hocking, G, 2003)
"Ketamine is an effective analgesic agent for treating a variety of neuropathic and cancer pain syndromes."8.82Parenteral ketamine as an analgesic adjuvant for severe pain: development and retrospective audit of a protocol for a palliative care unit. ( Fitzgibbon, EJ; Viola, R, 2005)
"To review the clinical literature evaluating the utilization of intravenous ketamine for the management of cancer-related pain, to summarize the data that suggest ketamine is an appropriate adjuvant method of providing analgesia and to report a case of successful pain management using ketamine in a patient with recurrent testicular cancer at our institution."8.81Adjuvant ketamine analgesia for the management of cancer pain. ( Baroletti, SA; McQueen, AL, 2002)
"Ketamine infusions are frequently employed for refractory complex regional pain syndrome (CRPS), but there are limited data on factors associated with treatment response."8.31Sympathetic Blocks as a Predictor for Response to Ketamine Infusion in Patients with Complex Regional Pain Syndrome: A Multicenter Study. ( Cheng, J; Cohen, SJ; Cohen, SP; Khunsriraksakul, C; Moon, JY; Parker, E; Patel, N; Samen-Akinsiku, CDK; Yoo, Y; Yuan, X, 2023)
"Depressive symptom severity and the affective index of pain partially mediated improvements in social function after six repeated ketamine treatments among patients with bipolar or unipolar depressive disorder."8.31Pain mediates the improvement of social functions of repeated intravenous ketamine in patients with unipolar and bipolar depression. ( Gan, Y; Hu, Z; Lan, X; Li, N; Li, W; Liu, H; Ning, Y; Wang, C; Wu, Z; Ye, Y; Zhang, F; Zhou, Y, 2023)
"Following recognition of opioid induced hyperalgesia, the patient was managed with opioid rotation and ketamine, which resulted in prompt alleviation of pain."8.12Role of Ketamine and Opioid Rotation in the Management of Opioid Induced Hyperalgesia in a Patient With Acute Promyelocytic Leukemia. ( Akhtari, M; Cao, H; Hino, C; Ran-Castillo, D; Silvestre, J, 2022)
"The objective of our study was to determine safety and pharmacology (pharmacokinetics and preliminary efficacy) of intranasal (IN) ketamine for uncontrolled cancer-related pain."8.12A dose-escalation clinical trial of intranasal ketamine for uncontrolled cancer-related pain. ( Beumer, JH; Curseen, K; Egan, K; Gillespie, TW; Harvey, RD; Lane, O; Shteamer, JW; Singh, V; Sniecinski, R; Spektor, B; Switchenko, J; Tsvetkova, M; Zarrabi, AJ, 2022)
"To report on an unusual case of ketamine-precipitated syndrome of inappropriate antidiuretic hormone secretion (SIADH) in an individual managed by an outpatient pain specialty team."8.12Ketamine-precipitated syndrome of inappropriate antidiuretic hormone secretion in a patient with persistent lumbar pain: a case report. ( Lau, A; van Bockxmeer, JJ; Varshney, V, 2022)
" Inclusion criteria were 16 years or older, two or more documented pain assessments, at least one indicating severe pain, and administration of opioids and/or low-dose ketamine."8.12Opioid sparing effect of ketamine in military prehospital pain management-A retrospective study. ( Avital, G; Benov, A; Cohen, B; Gelikas, S; Kontorovich-Chen, D; Radomislensky, I; Talmy, T, 2022)
" However, to the best of our knowledge, no study has reported on endotracheal intubation without the use of muscle relaxants under anesthetic management with remimazolam, nor on the combination of remimazolam and ketamine."8.12Effective anesthetic management with remimazolam and ketamine without muscle relaxants for parotidectomy in a patient with myotonic dystrophy: A case report. ( Habu, MI; Ishida, Y; Toba, Y, 2022)
" Additionally, dissociative sedation ketamine for severe agitation/excited delirium led to less endotracheal intubation than reported in the prehospital literature."7.96Ketamine Safety and Use in the Emergency Department for Pain and Agitation/Delirium: A Health System Experience. ( Campbell, MJ; Casserly, E; Fertel, BS; Lam, SW; Meldon, SW; Mo, H; Wells, EJ, 2020)
"Sprague-Dawley rats (11-13 weeks) were randomly assigned to control (saline vehicle), fentanyl, or ketamine-treated groups with or without hemorrhage (n = 8 or 9 for each group)."7.96Fentanyl impairs but ketamine preserves the microcirculatory response to hemorrhage. ( Calderon, AS; Hinojosa-Laborde, C; Klemcke, HG; Ryan, KL; Scott, LL; Xiang, L, 2020)
" Ketamine can quickly relieve depression, and its subcutaneous administration appears to be as effective as and probably safer than its standard intravenous administration."7.96Repeated subcutaneous esketamine administration for depressive symptoms and pain relief in a terminally ill cancer patient: A case report. ( Barbosa, MG; Delfino, RS; Jackowski, AP; Sarin, LM, 2020)
" Ketamine is on the WHO's list of essential medications and is used for a variety of pharmacologic applications including anesthesia and acute pain management."7.96Ketamine for pain control of snake envenomation in Guinea: A case series. ( Balde, C; Benjamin, JM; Brandehoff, N; Chippaux, JP, 2020)
"Ketamine is beneficial in clinical settings ranging from procedural sedation to the treatment of chronic pain."7.96Ketamine for Acute Pain Management and Sedation. ( Brown, K; Tucker, C, 2020)
"Therapeutic interventions for neuropathic pain, such as the N-methyl-D-aspartate (NMDA) antagonist ketamine, can vary widely in effectiveness."7.91Plasticity in the dynamic pain connectome associated with ketamine-induced neuropathic pain relief. ( Bhatia, A; Bosma, RL; Cheng, JC; Davis, KD; Hemington, KS; Kim, JA; Osborne, NR; Rogachov, A; Venkatraghavan, L, 2019)
"Although ketamine analgesia is effective in reducing pain and facilitating the tracheal intubation of newborns in the delivery room, no data on the neurological effects of this treatment are available."7.88Prospective follow-up of a cohort of preterm infants<33 WG receiving ketamine for tracheal intubation in the delivery room: Neurological outcome at 1 and 2 years. ( Elalouf, C; Fontaine, C; Gondry, J; Kongolo, G; Le Moing, AG; Leke, A; Tourneux, P, 2018)
"Our objective was to describe dosing, duration, and pre- and post-infusion analgesic administration of continuous intravenous sub-dissociative dose ketamine (SDK) infusion for managing a variety of painful conditions in the emergency department (ED)."7.88Continuous Intravenous Sub-Dissociative Dose Ketamine Infusion for Managing Pain in the Emergency Department. ( Beals, T; Drapkin, J; Fromm, C; Likourezos, A; Marshall, J; Monfort, R; Motov, S, 2018)
"WHAT THIS ARTICLE TELLS US THAT IS NEW: BACKGROUND:: Ketamine is an N-methyl-D-aspartate receptor antagonist that reduces temporal summation of pain and modulates antinociception."7.88Brain Dynamics and Temporal Summation of Pain Predicts Neuropathic Pain Relief from Ketamine Infusion. ( Bhatia, A; Bosma, RL; Cheng, JC; Davis, KD; Hemington, KS; Kim, JA; Osborne, NR; Rogachov, A; Venkat Raghavan, L, 2018)
"The study evaluated the effect of intra-articular injections of ketamine and 25% dextrose with triamcinolone acetate (TA) and hyaluronic acid (HA) on joint pathology and pain behavior in monosodium iodoacetate (MIA)-induced osteoarthritis (OA) in experimental mice."7.85Intra-articular injections of ketamine and 25% dextrose improve clinical and pathological outcomes in the monosodium iodoacetate model of osteoarthritis. ( Brahma, S; Jalgaonkar, SV; Koli, PG; Kshirsagar, S; Patil, AE; Rege, NN; Salgaonkar, S; Shetty, YC; Teltumbde, PA, 2017)
"We report a case series on the observed effects of low-dose ketamine infusions in 4 critically ill patients with varying complications related to prolonged critical illness."7.83Low-Dose Ketamine in Chronic Critical Illness. ( Darrah, D; Moitra, A; Moitra, VK; Patel, MK; Wunsch, H, 2016)
"This study compared effects of the NMDA receptor antagonists ketamine and MK-801 in assays of pain-stimulated and pain-depressed behaviour in rats."7.83Effects of the noncompetitive N-methyl-d-aspartate receptor antagonists ketamine and MK-801 on pain-stimulated and pain-depressed behaviour in rats. ( Hillhouse, TM; Negus, SS, 2016)
"Intravenous ketamine treatment is frequently used for the management of chronic pain, especially in those patients who do not benefit from other therapies."7.83[Safety and efficacy of ketamine for pain relief]. ( Dahan, A; Niesters, M; van Kleef, M, 2016)
"Immunoglobulin E, ketamine cystitis, interstitial cystitis."7.83The Role of Immunoglobulin E in the Pathogenesis of Ketamine Related Cystitis and Ulcerative Interstitial Cystitis: An Immunohistochemical Study. ( Hsu, YH; Jhang, JF; Jiang, YH; Kuo, HC, 2016)
"The objective of this systematic review is to examine the best available evidence on the clinical effectiveness of ketamine as an adjuvant to opioid-based therapy versus opioid-based therapy alone in decreasing perioperative pain associated with opioid tolerance in adult patients, aged 18-70 years, undergoing orthopedic surgical procedures."7.83Effectiveness of ketamine as an adjuvant to opioid-based therapy in decreasing pain associated with opioid tolerance in adults undergoing orthopedic surgery: a systematic review protocol. ( Bennett, M; Bonanno, L; Kuhn, W, 2016)
"A low-dose ketamine infusion protocol provided significant pain relief with mostly mild side effects and no severe adverse events."7.81Low-Dose Ketamine Infusion for Emergency Department Patients with Severe Pain. ( Ahern, TL; Frazee, BW; Herring, AA; Miller, S, 2015)
"Before updating the French guidelines on postoperative pain treatment in 2015, the Pain Committee of the French Society of Anaesthesiology and Intensive Care (SFAR) conducted a survey on the medical use of ketamine in France."7.81Ketamine for pain management in France, an observational survey. ( Beloeil, H; Derivaux, B; Martinez, V, 2015)
"We studied the role of a low-dose intravenous (IV) ketamine-midazolam combination in the management of severe painful sickle cell crisis."7.80The role of a low-dose ketamine-midazolam regimen in the management of severe painful crisis in patients with sickle cell disease. ( Faris, AS; Kausalya, R; Tawfic, QA, 2014)
"In this retrospective study, the medical records of 50 patients hospitalized on medical and surgical units at our facility who had continuous intravenous infusions of ketamine for pain or mild sedation were reviewed."7.80Psychiatric side effects of ketamine in hospitalized medical patients administered subanesthetic doses for pain control. ( Rasmussen, KG, 2014)
"Examine response patterns to low-dose intravenous (IV) ketamine continuous infusions on multiple pain outcomes, and demonstrate effectiveness, safety, and tolerability of ketamine administration on general wards."7.79Effects of low-dose IV ketamine on peripheral and central pain from major limb injuries sustained in combat. ( Buckenmaier, CC; Gallagher, RM; Goldberg, C; Hanlon, AL; Kwon, KH; Polomano, RC; Rupprecht, C, 2013)
"The ketamine pharmacokinetics in children with minor burns are similar to those without burns."7.77Exploring the pharmacokinetics of oral ketamine in children undergoing burns procedures. ( Anderson, BJ; Brunette, KE; Herd, DW; Schulein, S; Thomas, J; Wiesner, L, 2011)
"To investigate the expression of protein kinase C (PKC) in the spinal dorsal horn of rats with formalin-induced pain and the effect of intrathecal ketamine on PKC expression."7.77[Effect of intrathecal ketamine injection on protein kinase C expression in the spinal dorsal horn of rats with formalin-induced pain]. ( GUO, QL; WANG, E; YAN, JQ; YANG, Y; ZOU, WY, 2011)
"Compared to ketamine + no VR, both patients reported less pain during ketamine + VR for all three pain ratings."7.77Combining ketamine and virtual reality pain control during severe burn wound care: one military and one civilian patient. ( Desocio, PA; Fowler, M; Gaylord, KM; Hoffman, HG; Maani, CV; Maiers, AJ, 2011)
"We investigated the heat pain threshold (HPT) and temporal summation threshold (TST) before and after target-controlled infusion (TCI) of ketamine with an effect-site concentration (Ce) of 30 and 60 ng/ml."7.77The effect of target-controlled infusion of low-dose ketamine on heat pain and temporal summation threshold. ( Chae, WS; Cho, SH; Jin, HC; Kim, SH; Kim, YI; Lee, JH; Lee, JS, 2011)
"The aim of the study was to explore the analgesic effect of the N-methyl-d-aspartate receptor (NMDAR) antagonist ketamine in acute experimental versus chronic spontaneous pain in Complex Regional Pain Syndrome type 1 (CRPS-1) patients."7.76An observational study on the effect of S+-ketamine on chronic pain versus experimental acute pain in Complex Regional Pain Syndrome type 1 patients. ( Bauer, M; Dahan, A; Mooren, R; Noppers, I; Olofsen, E; Sarton, E; Sigtermans, M, 2010)
"Five children and adolescents received a low-dose ketamine infusion for the treatment of sickle cell-related pain."7.76Use of low-dose ketamine infusion for pediatric patients with sickle cell disease-related pain: a case series. ( Corsi, JM; Hagstrom, JN; Loiselle, KA; Zempsky, WT, 2010)
"To assess the efficacy of adding ketamine to morphine nurse- or patient-controlled analgesia (NCA/PCA) infusions in treating mucositis pain in children."7.76The addition of ketamine to a morphine nurse- or patient-controlled analgesia infusion (PCA/NCA) increases analgesic efficacy in children with mucositis pain. ( Howard, RF; James, PJ; Williams, DG, 2010)
"The ketamine (ket) model reflects features of schizophrenia as well as secondary symptoms such as altered pain sensitivity."7.75Haloperidol and risperidone have specific effects on altered pain sensitivity in the ketamine model of schizophrenia. ( Becker, A; Grecksch, G; Hiemke, C; Ladstaetter, E; Schmitt, U; Zernig, G, 2009)
"The purpose of this study was to examine possible peripheral mechanisms for the reduction of propofol injection pain by the addition of ketamine."7.75Preventing pain on injection of propofol: a comparison between peripheral ketamine pre-treatment and ketamine added to propofol. ( Do, SH; Hwang, J; Jeon, YT; Lee, SC; Lim, YJ; Park, HP, 2009)
"To improve opioid repsonse in patients with movement-related pain by using opioid switching adding a burst of ketamine."7.75Opioid switching and burst ketamine to improve the opioid response in patients with movement-related pain due to bone metastases. ( Arcuri, E; David, F; Ferrera, P; Mercadante, S; Villari, P, 2009)
"Our objective was to determine if an oral ketamine swish and expectorate was a safe and effective method to alleviate mucositis pain."7.75Ketamine mouthwash for mucositis pain. ( Atayee, RS; Lin, F; Ryan, AJ, 2009)
"Low-dose ketamine behaves as an analgesic in the treatment of acute and chronic pain."7.75S(+)-ketamine effect on experimental pain and cardiac output: a population pharmacokinetic-pharmacodynamic modeling study in healthy volunteers. ( Bauer, M; Dahan, A; Kest, B; Mooren, R; Olofsen, E; Sarton, E; Sigtermans, M, 2009)
" Since 2005 to 2007, we evaluated the safety and efficacy of ketamine to control pain induced by diagnostic procedures in pediatric oncology patients."7.75[Sedation using ketamine for pain procedures in Pediatric Oncology.]. ( Bernard, F; Ricard, C; Tichit, R; Troncin, R, 2009)
" infusion of propofol, or propofol plus ketamine for deep sedation and analgesia was carried out in two patients with severe epidermolysis bullosa (EB) during extensive dressing changes and deep whirlpool baths."7.74Deep sedation with intravenous infusion of combined propofol and ketamine during dressing changes and whirlpool bath in patients with severe epidermolysis bullosa. ( Wu, J, 2007)
"We report the use of an intravenous ketamine infusion for 37 days in a 9-year-old child with 42% body surface area burns."7.74Long-term use of an intravenous ketamine infusion in a child with significant burns. ( Karsli, C; White, MC, 2007)
"This prospective audit was undertaken in order to document the analgesic response and adverse effects of concurrent short-term ('burst') triple-agent analgesic (ketamine, an opioid and an anti-inflammatory agent--either steroidal or non-steroidal) administration, for episodes of acute on chronic pain."7.73Prospective audit of short-term concurrent ketamine, opioid and anti-inflammatory ('triple-agent') therapy for episodes of acute on chronic pain. ( Ashby, M; Good, P; Goodchild, C; Jackson, K; Tullio, F, 2005)
"Pretreatment with intravenous ketamine inhibits inflammatory pain behavior and FLI expression following a formalin injection in rats, suggesting that pretreatment of ketamine plays an important role in preemptive analgesia."7.73Preemptive effect of intravenous ketamine in the rat: concordance between pain behavior and spinal fos-like immunoreactivity. ( Lee, IH; Lee, IO, 2005)
"Questions have been raised about the potential neurotoxicity of the neuraxial use of ketamine although ketamine and its active enantiomer S(+)-ketamine have been used intrathecally and epidurally (caudally) for the management of perioperative pain and in a variety of chronic pain syndromes."7.73Neuropathological findings after continuous intrathecal administration of S(+)-ketamine for the management of neuropathic cancer pain. ( Kruis, MR; Troost, D; van der Vegt, MH; Vranken, JH; Wegener, JT, 2005)
" The present study examined the effects of combinations of dextromethorphan and ketamine, two clinically used N-methyl-D-aspartate (NMDA) receptor antagonists, with amitriptyline on formalin-evoked behaviors and paw edema."7.72Peripheral interactions between dextromethorphan, ketamine and amitriptyline on formalin-evoked behaviors and paw edema in rats. ( Reid, A; Sawynok, J, 2003)
" We investigated here the effects of ketamine anesthesia on somatosensory processing in the rat spinal cord, thalamus, and cerebral cortex, using the quantitative 2-deoxyglucose mapping technique."7.72Effects of ketamine anesthesia on central nociceptive processing in the rat: a 2-deoxyglucose study. ( Baraldi, P; Cavazzuti, M; Giuliani, D; Lui, F; Porro, CA; Vellani, V, 2004)
"To determine whether intraarticular pretreatment with N-methyl-D-aspartic (NMDA) receptor antagonist ketamine or memantine currently used in humans has prophylactic analgesia in arthritic pain, we examined the effects of their intraarticular injection before carrageenan injection into the knee joint on pain-related behavior and spinal c-Fos expression in rats."7.72Intraarticular pretreatment with ketamine and memantine could prevent arthritic pain: relevance to the decrease of spinal c-fos expression in rats. ( Back, SK; Han, HC; Hong, SK; Kim, YI; Lee, KS; Min, SS; Na, HS; Yoon, SJ; Yoon, YW; Zhang, GH, 2004)
"The present study examined the effects of local peripheral and systemic administration of three clinically used excitatory amino acid receptor antagonists (dextromethorphan, memantine, ketamine) on pain behaviors and edema produced by formalin (1."7.71Modulation of formalin-induced behaviors and edema by local and systemic administration of dextromethorphan, memantine and ketamine. ( Reid, A; Sawynok, J, 2002)
"Three patients with localized superficial pain had their pain alleviated by single epidural infusion with low dose ketamine."7.71[Usefulness of epidural infusion of ketamine for relief of localized superficial pain]. ( Ikeda, M; Kamakura, T; Machida, K; Mizuno, J; Sugimoto, S, 2001)
"In this study, we compared pain reduction produced by IV drugs (ketamine or alfentanil) with the ability to prevent injury-induced spinal cord changes."7.70Pre- versus postformalin effects of ketamine or large-dose alfentanil in the rat: discordance between pain behavior and spinal Fos-like immunoreactivity. ( Coderre, TJ; Gilron, I; Quirion, R, 1999)
"We evaluated the safety and efficacy of midazolam-ketamine association to control pain induced by diagnostic procedures in paediatric oncology patients."7.70Use of intravenous ketamine-midazolam association for pain procedures in children with cancer. A prospective study. ( Granry, JC; Le Moine, P; Monrigal, JP; Pellier, I; Rialland, X; Rod, B, 1999)
"The aim of the present study was to observe the effect of repeated subcutaneous (sc) injections of low doses of ketamine for the treatment of acute inflammatory pain in a complete Freund's adjuvant-induced monoarthritic pain model in rats."7.70Repeated administration of low dose ketamine for the treatment of monoarthritic pain in the rat. ( Cao, Y; Han, JS; Huang, C; Wang, Y, 2000)
"To assess the benefit of ketamine addition to a morphine-clonidine-lidocaine mixture administered continuously by the intrathecal route for the treatment of cancer pain."7.69[Cancer pain: beneficial effect of ketamine addition to spinal administration of morphine-clonidine-lidocaine mixture]. ( Lemos, D; Muller, A, 1996)
"We report the effect of a single daily dose of ketamine in a 54 year old woman with fibromyalgia and severe post-traumatic neuropathic pain."7.69[Analgesic effect of ketamine in a patient with neuropathic pain]. ( Fagerlund, TH; Oye, I; Rabben, T, 1996)
"The therapeutic effects of dextrorphan and ketamine, two non-competitive N-methyl-D-aspartate (NMDA) receptor antagonists, on neuropathic pain-related behaviors were examined in rats with peripheral mononeuropathy induced by loose ligation of the common sciatic nerve (chronic constrictive injury, CCI)."7.68Intrathecal treatment with dextrorphan or ketamine potently reduces pain-related behaviors in a rat model of peripheral mononeuropathy. ( Frenk, H; Hayes, RL; Lu, J; Mao, J; Mayer, DJ; Price, DD, 1993)
"Our experience has shown ketamine to be a safe and effective method of providing pain relief during specific procedures in burned children."7.68Ketamine. A solution to procedural pain in burned children. ( Groeneveld, A; Inkson, T, 1992)
"The effect of ketamine infusion to control the intractable pain which had not responded to ordinary procedures in 12 patients with advanced cancer were evaluated."7.68[Ketamine infusion for control of pain in patients with advanced cancer]. ( Kanamaru, T; Katsumata, N; Mizuno, K; Ogawa, S; Saeki, S; Suzuki, H, 1990)
"Continuous intravenous infusions of ketamine and pentazocine have been used to provide analgesia in 18 patients with acute war injuries."7.67Infusion analgesia for acute war injuries. A comparison of pentazocine and ketamine. ( Bion, JF, 1984)
" doses of the full benzodiazepine inverse agonist beta-CCE immediately following cessation of exposure of rats to an anesthetic concentration of methoxyflurane significantly antagonized the duration of methoxyflurane anesthesia as measured by recovery of the righting reflex and/or pain sensitivity."7.67Antagonism of methoxyflurane-induced anesthesia in rats by benzodiazepine inverse agonists. ( Miller, DW; Tessel, RE; Yourick, DL, 1989)
"Ketamine has analgesic and antidepressant effects, but few studies have evaluated individual differences in antidepressant outcomes to repeated ketamine in TRD patients with comorbid pain."7.01Plasma inflammatory cytokines and treatment-resistant depression with comorbid pain: improvement by ketamine. ( Chao, Z; Lan, X; Li, H; Ning, Y; Wang, C; Zhou, Y, 2021)
" Secondary outcomes included postoperative visual analog scale (VAS) scores for pain and adverse effects associated with ketamine."7.01Efficacy and safety of perioperative application of ketamine on postoperative depression: A meta-analysis of randomized controlled studies. ( Gu, HW; Guo, J; Hashimoto, K; Qiu, D; Wang, XM; Yang, JJ; Zhang, GF, 2023)
"IN ketamine was administered at enrolment, with a supplementary dose after 15 min, if required."6.78Sub-dissociative dose intranasal ketamine for limb injury pain in children in the emergency department: a pilot study. ( Graudins, A; Meek, R; Oakley, E; Yeaman, F, 2013)
"Propofol is a widely used anesthetic drug because of its minor complication and also its fast effect."6.77Comparison of effects of ephedrine, lidocaine and ketamine with placebo on injection pain, hypotension and bradycardia due to propofol injection: a randomized placebo controlled clinical trial. ( Ayatollahi, V; Behdad, S; Kargar, S; Yavari, T, 2012)
"Cold allodynia and hyperalgesia are frequent clinical findings in patients with neuropathic pain."6.71Cold allodynia and hyperalgesia in neuropathic pain: the effect of N-methyl-D-aspartate (NMDA) receptor antagonist ketamine--a double-blind, cross-over comparison with alfentanil and placebo. ( Jørum, E; Stubhaug, A; Warncke, T, 2003)
" Intranasal ketamine was well tolerated with no serious adverse events."6.71Safety and efficacy of intranasal ketamine for the treatment of breakthrough pain in patients with chronic pain: a randomized, double-blind, placebo-controlled, crossover study. ( Albin, R; Brennen, L; Brookoff, D; Carr, DB; Denman, WT; Firestone, L; Goudas, LC; Green, G; Hamilton, D; Lavin, PT; Mermelstein, F; Rogers, MC; Staats, PS, 2004)
"The reduction in allodynia evoked by light stroking was statistically significant only for alfentanil."6.68Effects of intravenous ketamine, alfentanil, or placebo on pain, pinprick hyperalgesia, and allodynia produced by intradermal capsaicin in human subjects. ( Bennett, GJ; Gracely, RH; Max, MB; Park, KM; Robinovitz, E, 1995)
"Ischemic pain was induced by the submaximum effort tourniquet technique."6.67The influence of adenosine, ketamine, and morphine on experimentally induced ischemic pain in healthy volunteers. ( Ekblom, A; Segerdahl, M; Sollevi, A, 1994)
"Ketamine is an NMDA-blocking agent widely used in human medicine."6.67Response of chronic neuropathic pain syndromes to ketamine: a preliminary study. ( Arndt, G; Backonja, M; Check, B; Gombar, KA; Zimmermann, M, 1994)
"Ketamine has unique pharmacologic properties that may prevent the development of pain as well as reduce chronic pain."6.58Emerging Trends in Pain Medication Management: Back to the Future: A Focus on Ketamine. ( Atkinson, TJ; Bryant, C; Crumb, MW, 2018)
" A literature review was performed to ascertain potential side effects and/or adverse events when using ketamine for analgesia purposes."6.55Ketamine for Pain Management-Side Effects & Potential Adverse Events. ( Allen, CA; Ivester, JR, 2017)
"Ketamine is a fast acting N-methyl-d-aspartate (NMDA) receptor antagonist that provides safe and effective analgesia."6.55Low dose ketamine use in the emergency department, a new direction in pain management. ( Alhawas, R; Mazer-Amirshahi, M; Pourmand, A; Royall, C; Shesser, R, 2017)
"Ketamine is a phencyclidine derivative, which functions primarily as an antagonist of the N-methyl-D-aspartate receptor."6.53Ketamine: A Review of Clinical Pharmacokinetics and Pharmacodynamics in Anesthesia and Pain Therapy. ( Hagelberg, NM; Olkkola, KT; Peltoniemi, MA; Saari, TI, 2016)
"Studies on oral ketamine for cancer and neuropathic pain have shown mixed results which could be partially due to significant differences in hepatic metabolism."6.48Oral ketamine in the palliative care setting: a review of the literature and case report of a patient with neurofibromatosis type 1 and glomus tumor-associated complex regional pain syndrome. ( Baker, K; Berger, AM; Handel, D; Mannes, AJ; Ruppert, SL; Soto, E; Stewart, DR; Zlott, D, 2012)
"Ketamine is a lipophilic, general anesthetic."6.48Ketamine for pain: an update of uses in palliative care. ( Prommer, EE, 2012)
"Ketamine has become increasingly recognized as a drug of recreational use."6.47Recreational ketamine: from pleasure to pain. ( Baker, SC; Cottrell, A; Fulford, S; Gillatt, D; Harris, M; Southgate, J; Wood, D; Woodhouse, C, 2011)
"Ketamine is an N-methyl-D-aspartate receptor antagonist that has been in clinical use in the USA for over 30 years."6.47Ketamine in pain management. ( Cohen, SP; Gupta, A; Liao, W; Plunkett, A, 2011)
" There was no consistent dose-response relation."6.46Use of oral ketamine in chronic pain management: a review. ( Blonk, MI; Huygen, FJ; Koder, BG; van den Bemt, PM, 2010)
"Ketamine has been shown to produce antihyperalgesic effects produced by incision and tissue or nerve damage, and has become popular in equine practice as an anesthetic and more recently as an analgesic for standing surgical procedures and the treatment of laminitis."6.46NMDA receptor antagonists and pain: ketamine. ( Muir, WW, 2010)
"Ketamine is a dissociative anaesthetic that has been used in the clinic for many years."6.44Low dose ketamine: a therapeutic and research tool to explore N-methyl-D-aspartate (NMDA) receptor-mediated plasticity in pain pathways. ( Chizh, BA, 2007)
" Nursing considerations include close monitoring of vital signs during the initial dosage and follow-up observations of the effectiveness of the medications."6.44The use of ketamine as adjuvant therapy to control severe pain. ( Campbell-Fleming, JM; Williams, A, 2008)
"Ketamine is a dissociative anaesthetic; its mechanism of action is primarily an antagonism of the N-methyl-D-aspartate (NMDA) receptor."6.43The role of ketamine in pain management. ( Schug, SA; Visser, E, 2006)
"Ketamine has been shown to have potent analgesic properties at low dosages."6.39Ketamine in cancer pain: an update. ( Mercadante, S, 1996)
" This study aimed to evaluate differences in pain management and adverse effects of ketamine and opioid administration."5.91Treating Prehospital Pain in Children: A Retrospective Chart Review Comparing the Safety and Efficacy of Prehospital Pediatric Ketamine and Opioid Analgesia. ( Brent, C; Cranford, JA; Hunt, N; Mahmood, A; Masiewicz, S; Noel, S; Wagner, D, 2023)
"Ketamine was started a median of 13."5.91Ketamine use for management of vaso-occlusive pain in pediatric sickle cell disease. ( Archer, NM; Donado, C; Greco, C; Harris, EM; Heeney, MM; Solodiuk, J; Vilk, E; Williams, A, 2023)
"Ketamine has been used in the emergency department (ED) as an anesthetic agent for procedural sedation, and when administrated in a sub-dissociative dose (low dose) at 0."5.72Paraphimosis Pain Treatment with Nebulized Ketamine in the Emergency Department. ( Barberan Parraga, C; Cen, E; Davis, A; Dove, D; Drapkin, J; Fassassi, C; Hossain, R; Mahl, E; Motov, S; Peng, Y, 2022)
"Erythromelalgia is a rare neurovascular pain condition characterized by erythematous, warm, and painful extremities."5.72Intravenous Ketamine Infusion as an Adjunctive Pain Treatment for Erythromelalgia: A Pediatric Case Report. ( Adams, AC; Montoya, L; Popenhagen, MP; Price, HN; Russi, DC; Singhal, NR, 2022)
"Ketamine infusions have been reported to help alleviate acute exacerbations or "flare-ups" of CRPS symptoms."5.56Anesthetic Management of a Complex Regional Pain Syndrome (CRPS) Patient With Ketamine. ( Mundluru, T; Saraghi, M, 2020)
" Complications including apnea, hypotension, hypoxia, nausea, and vomiting, along with gastroenterologist satisfaction and patients' pain score (based on Wong-Baker faces pain assessment scale), were recorded by a checklist."5.51Comparing the Efficacy and Safety of Dexmedetomidine/Ketamine with Propofol/Fentanyl for Sedation in Colonoscopy Patients: A Doubleblinded Randomized Clinical Trial. ( Aghaali, M; Ahmadpour, S; Alemi, F; Aminnejad, R; Hormati, A; Hormati, M; Sabouri, SM; Saeidi, M; Shafiee, H, 2022)
"Patients with advanced cancer often suffer from both severe pain and severe symptoms of depression."5.48Case Report: Ketamine for Pain and Depression in Advanced Cancer. ( Atayee, RS; Bruner, HC; Sexton, J, 2018)
" This adverse effect has not been reported previously at this dosing range."5.46A Case Report: Subanesthetic Ketamine Infusion for Treatment of Cancer-Related Pain Produces Urinary Urge Incontinence. ( Hunsberger, J; Lee, W; Vickers, BA, 2017)
"To investigate if intravenous fentanyl or intravenous ketamine can provide adequate analgesia in preterm infants undergoing laser photocoagulation for retinopathy of prematurity (ROP)."5.41'NOPAIN-ROP' trial: Intravenous fentanyl and intravenous ketamine for pain relief during laser photocoagulation for retinopathy of prematurity (ROP) in preterm infants: A randomised trial. ( Agarwal, R; Chandra, P; Deorari, A; Madathil, S; Sankar, MJ; Thomas, D; Thukral, A, 2021)
" Optimal nonsurgical management strategies for these patients have not been fully defined regarding level of care, incentive spirometry (IS), noninvasive positive pressure ventilation (NIPPV), and the use of ketamine, epidural, and other locoregional approaches to analgesia."5.41Non-surgical management and analgesia strategies for older adults with multiple rib fractures: A systematic review, meta-analysis, and joint practice management guideline from the Eastern Association for the Surgery of Trauma and the Chest Wall Injury Soc ( Agarwal, SK; Barraco, R; Bauman, ZM; Brooks, SE; Cantrell, S; Como, JJ; Crandall, M; Haines, KL; Haut, ER; Kaafarani, H; Kasotakis, G; Kaups, KL; Kim, B; Knowlton, LM; Mukherjee, K; Nirula, R; Schubl, SD; Shiroff, AM; Staudenmayer, K; Tominaga, G, 2023)
"We identified similar high rates of pain reduction and rare adverse events among pediatric patients who received ketamine or opioids."5.41A Comparison of Prehospital Pediatric Analgesic Use of Ketamine and Opioids. ( Chen, NW; Crowe, R; Frawley, J; Gappy, R; Goyal, A; Sandoval, S; Swor, R, 2023)
"  NMDA receptor antagonists versus no treatment, placebo, oral sweet solution, or non-pharmacological intervention One RCT evaluated using oral ketamine (10 mg/kg body weight) versus sugar syrup (66."5.41Non-opioid analgesics for procedural pain in neonates. ( Bruschettini, M; Persad, E; Pizarro, AB, 2023)
"In non-intubated general anesthesia, the combination of subclinical doses of esketamine and propofol did reduce circulatory and respiratory depression, injection pain, and other adverse effects, while the incidence of esketamine's own side effects such as neuropsychiatric reactions did not increase, and the combination of the two did not cause the occurrence of new and more serious adverse reactions, and the combination of the two was safe and effective."5.41Analysis of the efficacy of subclinical doses of esketamine in combination with propofol in non-intubated general anesthesia procedures - a systematic review and meta-analysis. ( Chen, H; Ding, X; Fu, Q; Li, P; Liu, Q; Xiang, G; Xu, L, 2023)
" Our review shows that: - There may be little or no difference in pain relief (single dose IN vs IV fentanyl MD 4 mm, 95% CI -8 to 16 at 30 min by 100 mm VAS; multiple doses IN vs IV fentanyl MD 0, 95%CI -0."5.41Intranasal analgesia for acute moderate to severe pain in children - a systematic review and meta-analysis. ( Austad, B; Iakovleva, E; Munblit, D; Pedersen, SA; Prescott, MG; Simpson, MR; Vallersnes, OM, 2023)
"Painful stimulation during light sedation with midazolam, but not ketamine, can be accompanied by increased coherence in brain connectivity, even though details are less likely to be recollected as explicit memories."5.41Midazolam and Ketamine Produce Distinct Neural Changes in Memory, Pain, and Fear Networks during Pain. ( Aizenstein, HJ; Citro, AT; Fiez, JA; Ibinson, JW; Karim, HT; Mahajan, A; Norton, CM; Popov, V; Reder, LM; Smith, CT; Vogt, KM, 2021)
"This study aimed to compare analgesic efficacy of intranasal (IN) ketamine to IN fentanyl for moderate to severe pain in children in a pediatric emergency department."5.41Analgesic Efficacy of Intranasal Ketamine Versus Intranasal Fentanyl for Moderate to Severe Pain in Children: A Prospective, Randomized, Double-Blind Study. ( Brady, J; Chitnis, SS; Drapkin, J; Fromm, C; Kriss, S; Likourezos, A; Motov, S; Pushkar, I; Quinn, K; Yasavolian, M, 2021)
"IN ketamine dose was 0."5.40Sub-dissociative-dose intranasal ketamine for moderate to severe pain in adult emergency department patients. ( Egerton-Warburton, D; Graudins, A; Meek, R; Rosengarten, P; Yeaman, F, 2014)
"The ketamine usage pattern was recorded: initiation, administration route, dose in the last month and frequency of usage."5.38[Cystitis and ketamine associated bladder dysfunction]. ( Arango, O; Bielsa, O; Castillo, C; García-Larrosa, A; Lorente, JA; Ventura, M, 2012)
"Pain was also improved, although for a shorter duration."5.38Mood and pain responses to repeat dose intramuscular ketamine in a depressed patient with advanced cancer. ( Glue, P; Perez, D; Zanicotti, CG, 2012)
"heat allodynia) followed by a persistent area of secondary tactile allodynia."5.36Human experimental pain models 3: heat/capsaicin sensitization and intradermal capsaicin models. ( Modir, JG; Wallace, MS, 2010)
"It had less effect on tactile allodynia (CCI)."5.35Effects of norketamine enantiomers in rodent models of persistent pain. ( Crooks, PA; Hojomat, M; Holtman, JR; Johnson-Hardy, JK; Kleven, M; Wala, EP, 2008)
"Oral ketamine has been found to be effective during invasive procedures in children with malignancy."5.35Oral ketamine for pain relief in a child with abdominal malignancy. ( Boyaci, A; Gulcu, N; Ugur, F, 2009)
"Premature infants experience untreated repetitive pain that may alter their brain development."5.34Ketamine reduces the cell death following inflammatory pain in newborn rat brain. ( Anand, KJ; Bhutta, AT; Garg, S; Hall, RW; Narsinghani, U; Rovnaghi, CR, 2007)
"Muscle pain is a major clinical problem but the underlying mechanisms and its pharmacological modulation need further investigation."5.32Pharmacological modulation of experimental phasic and tonic muscle pain by morphine, alfentanil and ketamine in healthy volunteers. ( Arendt-Nielsen, L; Graven-Nielsen, T; Jansson, Y; Schulte, H; Segerdahl, M; Sollevi, A, 2003)
"Dextromethorphan produced lower ED(50) values for morphine, fentanyl and sufentanil but exerted no effect on the potency of SNC80 or U50,488H."5.31Dextromethorphan and ketamine potentiate the antinociceptive effects of mu- but not delta- or kappa-opioid agonists in a mouse model of acute pain. ( Baker, AK; Hoffmann, VL; Meert, TF, 2002)
"Neuropathic pain has been shown to respond to drugs that block the N-methyl-D-aspartate (NMDA) receptor, such as ketamine and amantidine."5.31An unusual case of chronic neuropathic pain responds to an optimum frequency of intravenous ketamine infusions. ( Mitchell, AC, 2001)
"Ketamine is a non-competitive N-methyl D-aspartate (NMDA) receptor antagonist with analgesic and dissociative anesthetic properties."5.31Low dose ketamine as an analgesic adjuvant in difficult pain syndromes: a strategy for conversion from parenteral to oral ketamine. ( Fitzgibbon, EJ; Hall, P; Schroder, C; Seely, J; Viola, R, 2002)
"To determine whether intranasal ketamine is noninferior to intranasal fentanyl for pain reduction in children presenting with acute extremity injuries."5.30Effect of Intranasal Ketamine vs Fentanyl on Pain Reduction for Extremity Injuries in Children: The PRIME Randomized Clinical Trial. ( Caruso, M; Florin, TA; Frey, TM; Mittiga, MR; Zhang, N; Zhang, Y, 2019)
"His pain was diagnosed as neuropathic pain (complex regional pain syndrome, type II)."5.30The NMDA-receptor antagonist ketamine abolishes neuropathic pain after epidural administration in a clinical case. ( Miyazaki, M; Morita, S; Nanbu, T; Takahashi, H; Yanagida, H, 1998)
" This study aims to evaluate the efficacy and safety of subdissociative intranasal ketamine as a cheap, readily available and easily administered adjunct to standard pain therapy."5.24Subdissociative intranasal ketamine plus standard pain therapy versus standard pain therapy in the treatment of paediatric sickle cell disease vaso-occlusive crises in resource-limited settings: study protocol for a randomised controlled trial. ( Helm, E; Mfinanga, JA; Moore, CG; Nshom, E; Reynolds, SL; Runyon, MS; Sawe, HR; Young, JR, 2017)
" Ketamine mouthwashes have been used for pain relief, but supporting evidence is limited."5.24Treatment of severe mucositis pain with oral ketamine mouthwash. ( Craig, M; Cumpston, A; Hamadani, M; Kanate, AS; Shillingburg, A; Wen, S, 2017)
"Ketamine-associated uropathy frequently involves frequency, urgency, and suprapubic pain; upper urinary tract involvement is less common."5.22Systematic review and meta-analysis of ketamine-associated uropathy. ( Chan, EOT; Chan, VWS; Cheung, V; Ng, CF; Tang, TST; Teoh, JYC; Wong, MCS; Yee, CH, 2022)
"The 3 study groups showed a highly significant, similar maximal pain reduction of 56 ± 26 mm for IN Ketamine, and 59 ± 22 and 48 ± 30 for IV MO and IM MO, respectively."5.22Intranasal ketamine for acute traumatic pain in the Emergency Department: a prospective, randomized clinical trial of efficacy and safety. ( Gigi, R; Halpern, P; Nadav, D; Rozenek, M; Sarig-Meth, T; Shapira, A; Shimonovich, S; West, D, 2016)
"To determine the differences by comparing fentanyl and ketamine used in cancer-diagnosed children undergoing painful procedures."5.20The clinical effect of fentanyl in comparison with ketamine in analgesic effect for oncology procedures in children: a randomized, double-blinded, crossover trial. ( Monsereenusorn, C; Rujkijyanont, P; Traivaree, C, 2015)
"No difference was found in pain assessment during local anaesthetic injection between the group treated with midazolam and ketamine, and the group treated with midazolam alone."5.19A double-blind, randomised, placebo-controlled trial of oral midazolam plus oral ketamine for sedation of children during laceration repair. ( Assa, A; Barkan, S; Berkovitch, S; Breitbart, R; Brenner-Zada, G; Feldon, M; Kozer, E; Shavit, I; Toledano, M, 2014)
"This study was a long-term follow-up study of the prehospital, prospective, randomised, controlled, open-label study comparing ketamine with morphine in patients with trauma and a verbal pain score of >5 after 5 mg intravenous morphine."5.19Long-term pain prevalence and health-related quality of life outcomes for patients enrolled in a ketamine versus morphine for prehospital traumatic pain randomised controlled trial. ( Bernard, S; Cameron, P; Fitzgerald, M; Jennings, PA; Jolley, D; Masci, K; Walker, T, 2014)
" Before fracture reduction, children 3 to 17 years of age randomly received 2% lidocaine (L) or normal saline (NS) into the hematoma of their fracture site during sedation with intravenous ketamine and midazolam."5.19Evaluating the hematoma block as an adjunct to procedural sedation for closed reduction of distal forearm fractures. ( Constantine, E; Eberson, CP; Linakis, JG; Machan, JT; Steele, DW; Tsze, DS, 2014)
"Ketamine can completely eliminate pain associated with propofol injection."5.17An effective dose of ketamine for eliminating pain during injection of propofol: a dose response study. ( Wang, M; Wang, Q; Wang, WS; Yu, YY, 2013)
"The lidocaine-ketamine combination is most effective for decreasing the pain on propofol injection."5.17A prospective, randomized, double-blind study to compare the efficacy of lidocaine + metoclopramide and lidocaine + ketamine combinations in preventing pain on propofol injection. ( Chaudhary, K; Gogia, AR; Gupta, P, 2013)
"To investigate the effects of ketamine hydrochloride on the analgesic effects of tramadol hydrochloride in horses with signs of pain associated with naturally occurring chronic laminitis."5.16Effect of ketamine hydrochloride on the analgesic effects of tramadol hydrochloride in horses with signs of chronic laminitis-associated pain. ( Guedes, AG; Hood, DM; Matthews, NS, 2012)
"To evaluate the efficacy of ketamine in preventing propofol injection pain in children."5.16Prevention of propofol-induced pain in children: pretreatment with small doses of ketamine. ( Bao, SM; Guo, Y; Meng, LX; Zhang, LH; Zhao, GY, 2012)
" Nitrous oxide (N(2)O) has the advantages of being a sedative agent that does not require a painful injection and that offers shallower levels of sedation and a rapid recovery of mental state."5.16A randomized comparison of nitrous oxide versus intravenous ketamine for laceration repair in children. ( Eun, SC; Heo, CY; Jo, YH; Kim, K; Kim, SH; Kim, TY; Lee, JH; Rhee, JE, 2012)
"02 mg, % 2 lidocaine 40 mg, metoclopramide 10 mg, and ketamine 100 microg/kg yields propofol induced pain 38%, 76%, 76%, and 58% respectively."5.16The effects of remifentanil, lidocaine, metoclopramide, or ketamine pretreatment on propofol injection pain. ( Aktay, M; Ozlü, O; Polat, R, 2012)
"Long-term S(+)-ketamine treatment is effective in causing pain relief in CRPS-1 patients with analgesia outlasting the treatment period by 50 days."5.15Population pharmacokinetic-pharmacodynamic modeling of ketamine-induced pain relief of chronic pain. ( Aarts, L; Bauer, M; Dahan, A; Niesters, M; Noppers, I; Olofsen, E; Sarton, E; Sigtermans, M, 2011)
"The purpose of this study was to evaluate differences in pain intensity, pain quality, physiological measures, and adverse effects when patients received morphine with saline (MS) compared with morphine and a small dose of ketamine (MK) before an open wound care procedure (WCP)."5.15Efficacy of small doses of ketamine with morphine to decrease procedural pain responses during open wound care. ( Arroyo-Novoa, CM; Figueroa-Ramos, MI; Miaskowski, C; Padilla, G; Paul, SM; Puntillo, KA; Rodríguez-Ortiz, P; Stotts, NA, 2011)
"To assess the analgesic efficacy of the N-methyl-D-aspartate receptor antagonist S(+)-ketamine on fibromyalgia pain, the authors performed a randomized double blind, active placebo-controlled trial."5.15Absence of long-term analgesic effect from a short-term S-ketamine infusion on fibromyalgia pain: a randomized, prospective, double blind, active placebo-controlled trial. ( Aarts, L; Bauer, M; Dahan, A; Geleijnse, N; Mooren, R; Niesters, M; Noppers, I; Sarton, E; Swartjes, M, 2011)
"Sixteen patients with neuropathic pain of various origins were randomized into two treatment groups: (S)-ketamine 0."5.14Effects of low-dose intranasal (S)-ketamine in patients with neuropathic pain. ( Azad, SC; Beyer, A; Huge, V; Lauchart, M; Magerl, W; Schelling, G; Thieme, D, 2010)
"Administration of ketamine 100 microg x kg(-1) immediately before propofol injection is a safe and effective method in preventing propofol injection pain."5.14Prevention of propofol injection pain with small-dose ketamine. ( Nikooseresht, M; Seifrabie, M; Zahedi, H, 2009)
"5 mg kg(-1) ketamine reduced the incidence and intensity of propofol injection pain, whereas 1."5.14Ketamine eliminates propofol pain but does not affect hemodynamics during induction with double-lumen tubes. ( Furuya, H; Inoue, S; Iwata, M; Kawaguchi, M; Kimura, T; Taniguchi, S; Tojo, T, 2010)
" The aim of this study was to compare the level of pain during NG tube insertion in groups receiving local ketamine plus water-soluble lubricating gel and water-soluble lubricating gel alone (the latter is the common practice in our hospital)."5.14Ketamine improves nasogastric tube insertion. ( Golshani, K; Khashayar, P; Moharari, RS; Moradi Lakeh, M; Nejati, A, 2010)
"A study involving the use of a mixture of ketamine and midazolam delivered via patient-controlled analgesia (PCA) device was trialed to assess its effectiveness in reducing pain associated with repeated burns dressings in an adult population."5.13Ketamine and midazolam delivered by patient-controlled analgesia in relieving pain associated with burns dressings. ( MacPherson, RD; Penfold, J; Woods, D, 2008)
"This open-label trial suggests benefit in pain reduction, associated CRPS symptoms, improved quality of life and ability to work following anesthetic ketamine in previously refractory CRPS patients."5.13Efficacy of ketamine in anesthetic dosage for the treatment of refractory complex regional pain syndrome: an open-label phase II study. ( Altemeyer, KH; Dieterich, HJ; Grothusen, J; Kiefer, RT; Koffler, S; Ploppa, A; Rohr, P; Schwartzman, RJ; Unertl, K, 2008)
"Ketamine, but not calcitonin, reduced phantom limb pain."5.13Chronic phantom limb pain: the effects of calcitonin, ketamine, and their combination on pain and sensory thresholds. ( Arendt-Nielsen, L; Björgo, S; Curatolo, M; Eichenberger, U; Neff, F; Petersen-Felix, S; Sveticic, G, 2008)
"The comparison of ketamine with fentanyl for pain control of pediatric orthopedic emergencies remains controversial."5.12Influence of ketamine versus fentanyl on pain relief for pediatric orthopedic emergencies: A meta-analysis of randomized controlled studies. ( Qiu, J; Xie, M, 2021)
"To compare atropine with placebo as an adjunct to ketamine sedation in children undergoing minor painful procedures."5.12Is atropine needed with ketamine sedation? A prospective, randomised, double blind study. ( Geelhoed, GC; Heinz, P; Pascoe, EM; Wee, C, 2006)
"Ketamine significantly reduced ongoing pain and evoked pain to brush and pinprick, whereas lidocaine only reduced evoked pain to repetitive pinprick stimuli."5.12Differential effect of ketamine and lidocaine on spontaneous and mechanical evoked pain in patients with nerve injury pain. ( Bach, FW; Gottrup, H; Jensen, TS; Juhl, G, 2006)
"Little is known about the effects of low-dose S-(+)-ketamine on the cerebral processing of pain."5.12Imaging pain modulation by subanesthetic S-(+)-ketamine. ( Freynhagen, R; Kochs, EF; Sprenger, T; Tölle, TR; Valet, M; Wagner, KJ; Woltmann, R; Zimmer, C, 2006)
"Administration of ketamine 100 microg/kg immediately before propofol injection provided the optimal dose and timing to reduce propofol-induced pain on injection."5.12Small-dose ketamine reduces the pain of propofol injection. ( Cho, SJ; Ham, KD; Hwang, JH; Kim, YK; Koo, SW, 2006)
"The aim of the study was to compare in emergency settings 2 analgesic regimens, morphine with ketamine (K group) or morphine with placebo (P group), for severe acute pain in trauma patients."5.12Management of severe acute pain in emergency settings: ketamine reduces morphine consumption. ( Adnet, F; Catineau, J; Combes, X; Dolveck, F; Galinski, M; Lapostolle, F; Limoges, V; Pommier, V; Smaïl, N; Templier, F, 2007)
"Injection pain was twice as common with ketamine-propofol admixture than with lidocaine-propofol admixture."5.12A ketamine-propofol admixture does not reduce the pain on injection compared with a lidocaine-propofol admixture. ( Abdelaziz, AB; Cherif, R; Chettaoui, O; Kaabachi, O; Kokki, H; Ouezini, R, 2007)
"To test the hypothesis that local injection of the N-methyl-D-aspartate (NMDA) receptor antagonist ketamine would significantly attenuate glutamate-evoked masseter mechanical sensitization and muscle pain in healthy young women either taking oral contraceptives (W+OC) or not taking oral contraceptives (W-OC)."5.12Effect of a peripheral NMDA receptor antagonist on glutamate-evoked masseter muscle pain and mechanical sensitization in women. ( Arendt-Nielsen, L; Cairns, BE; Castrillon, EE; Ernberg, M; Sessle, BJ; Svensson, P; Wang, K, 2007)
"Propofol, a commonly used anesthetic, often causes pain on injection."5.12Painless injection of propofol: pretreatment with ketamine vs thiopental, meperidine, and lidocaine. ( Boker, A; Ertok, E; Saadawy, I, 2007)
"The aim of this study was to determine whether the follow-up of pain processing recovery in hyperalgesic fibromyalgia (FM) could be objectively evaluated with brain perfusion ethyl cysteinate dimer single photon computerized tomography (ECD-SPECT) after administration of ketamine."5.12Follow-up of pain processing recovery after ketamine in hyperalgesic fibromyalgia patients using brain perfusion ECD-SPECT. ( Cammilleri, S; Colavolpe, C; de Laforte, C; Guedj, E; Mundler, O; Niboyet, J, 2007)
"The analgesic subanesthetic dose of ketamine significantly reduced the pain scores, and this matched a decrease in activity within brain regions that activate in response to noxious stimuli, in particular, the insular cortex and thalamus."5.11An investigation to dissociate the analgesic and anesthetic properties of ketamine using functional magnetic resonance imaging. ( Longe, SE; Painter, DJ; Rogers, R; Tracey, I; Wise, RG, 2004)
"Ketamine but not lidocaine showed a significant analgesic effect in patients with neuropathic pain after spinal cord injury."5.11The analgesic effect of intravenous ketamine and lidocaine on pain after spinal cord injury. ( Gordh, T; Karlsten, R; Kvarnström, A; Quiding, H, 2004)
"This is the first experimental study in humans to find synergistic analgesic effects with coadministration of the N-methyl-D-aspartate receptor antagonist ketamine and morphine on pain involving central sensitization phenomena."5.11The synergistic effect of combined treatment with systemic ketamine and morphine on experimentally induced windup-like pain in humans. ( Schulte, H; Segerdahl, M; Sollevi, A, 2004)
"Midazolam/ketamine sedation has been used successfully in children undergoing painful invasive procedures."5.11Inter- and intraindividual variability in ketamine dosage in repetitive invasive procedures in children with malignancies. ( Aliani, S; Gottschling, S; Graf, N; Meyer, S, 2004)
"Small-dose of ketamine does not seem to be a useful adjunct to remifentanil-based anaesthesia during short, painful surgical procedures."5.11Ketamine does not decrease postoperative pain after remifentanil-based anaesthesia for tonsillectomy in adults. ( Lebrun, T; Polin, B; Sandefo, I; Van Elstraete, AC, 2004)
"Conscious sedation with rectally applied S(+)-ketamine and Midazolam allows safe and painless dressing changes after heat injuries in children."5.11Conscious sedation: Off-label use of rectal S(+)-ketamine and midazolam for wound dressing changes in paediatric heat injuries. ( Heinrich, M; Muensterer, OJ; Till, H; Wetzstein, V, 2004)
" Fentanyl also may reduce the pain of diazepam injection by blocking the opiate receptors in vessels walls."5.11The effect of ketamine and fentanyl in reducing the pain of diazepam injection. ( Azemati, M; Azemati, S; Khosravi, A; Khosravi, MB, 2004)
") ketamine sedation administered by nonanesthetist physicians for painful procedures."5.11Intravenous ketamine sedation for painful oncology procedures. ( Barbour, K; Evans, D; Kobe, J; Montgomery, CJ; Rogers, P; Turnham, L; Vandebeek, C; Wilson, L, 2005)
"This prospective, double-blind, randomized, placebo-controlled study compares the effects of ephedrine and ketamine on injection pain, and hypotension from propofol."5.11Comparison of ephedrine and ketamine in prevention of injection pain and hypotension due to propofol induction. ( Altunkaya, H; Ayoğlu, H; Ciçek, E; Demirel, CB; Ozer, Y; Ozkoçak, I, 2005)
"We evaluated whether preadministration of low-dose ketamine could attenuate tourniquet pain and arterial pressure increase using high tourniquet pressure in ten healthy awake volunteers."5.11Preadministration of low-dose ketamine reduces tourniquet pain in healthy volunteers. ( Fukusaki, M; Kanaide, M; Matsumoto, S; Sumikawa, K; Takada, M; Terao, Y; Yamashita, K, 2005)
"A double-blind, randomized, placebo-controlled 3-week study evaluated the efficacy of topical 2% amitriptyline, 1% ketamine, and a combination of both in treating patients with neuropathic pain."5.11Topical 2% amitriptyline and 1% ketamine in neuropathic pain syndromes: a randomized, double-blind, placebo-controlled trial. ( Clark, AJ; Lynch, ME; Sawynok, J; Sullivan, MJ, 2005)
"The aim of the present study was to clarify the neurophysiological changes associated with analgesic and behavioral effects of low-dose ketamine HCl in patients suffering from chronic neuropathic pain."5.10Effects of low-dose ketamine on neuropathic pain: An electroencephalogram-electrooculogram/behavioral study. ( Kato, J; Kojima, T; Matsuura, M; Nagashima, M; Oga, K; Ogawa, S; Saeki, S, 2002)
"The incidence of pain of the infusion was significantly lower in patients pretreated with ketamine (8% vs 37%, P = 0."5.10Pretreatment with intravenous ketamine reduces propofol injection pain. ( Barbi, E; Gagliardo, A; Gerarduzzi, T; Marchetti, F; Neri, E; Sarti, A; Ventura, A, 2003)
"The purpose of this study was to evaluate the effect of pre-treatment with ketamine on the reduction of pain during injection of propofol in adult patients."5.10[Pre-treatment with ketamine reduces incidence and severity of pain on propofol injection]. ( Kumazawa, T; Masamune, T; Nonaka, A; Suzuki, S, 2002)
"The aim of this study was to assess the efficacy of dextromethorphan and ketamine relative to placebo on the acute nociceptive threshold and wind-up of second pain response in healthy male volunteers."5.10Assessment of the effect of dextromethorphan and ketamine on the acute nociceptive threshold and wind-up of the second pain response in healthy male volunteers. ( Fisher, G; Growcott, JW; Hughes, AM; Rhodes, J; Sellers, M, 2002)
"We examined the role of N-methyl-D-aspartate (NMDA) receptors in chronic (pathological) pain in humans by using the NMDA receptor antagonist ketamine as a probe."5.09Prolonged analgesic effect of ketamine, an N-methyl-D-aspartate receptor inhibitor, in patients with chronic pain. ( Oye, I; Rabben, T; Skjelbred, P, 1999)
"Ketamine is a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist used recently for analgesia in patients with chronic pain."5.09Clinical experience with oral ketamine. ( Enarson, MC; Hays, H; Woodroffe, MA, 1999)
"Anecdotal reports suggest that the general anaesthetic drug ketamine, taken orally in low doses, can give rise to some extra analgesia in patients with refractory neuropathic pain."5.09N of 1 randomised controlled trials of oral ketamine in patients with chronic pain. ( Gaines, SP; Haines, DR, 1999)
" We showed that, as in animals, this phenomenon, which might represent an elementary form of the central sensitization involved in various painful syndromes, depends on the activation of N-methyl-D-aspartate receptors, because it was selectively reduced after the administration of ketamine."5.09The effects of ketamine on the temporal summation (wind-up) of the R(III) nociceptive flexion reflex and pain in humans. ( Bouhassira, D; Brasseur, L; Chauvin, M; Dupont, X; Guirimand, F, 2000)
"To assess the suitability of ketamine for relief of pain caused by tracheal suction during ventilator treatment in newborn infants."5.09Ketamine for procedural pain relief in newborn infants. ( Fellman, V; Huttunen, P; Neuvonen, PJ; Saarenmaa, E, 2001)
"Pain intensity, muscle strength, static muscle endurance, pressure pain threshold, and pain tolerance at tender points and control points were assessed in 31 patients with fibromyalgia (FM), before and after intravenous administration of morphine (9 patients), lidocaine (11 patients), and ketamine (11 patients)."5.08Pain analysis in patients with fibromyalgia. Effects of intravenous morphine, lidocaine, and ketamine. ( Bäckman, E; Bengtsson, A; Bengtsson, M; Henriksson, KG; Sörensen, J, 1995)
" A few small studies in patients have suggested that intravenous boluses or rapid infusions of the N-methyl-D-aspartate (NMDA) antagonist ketamine relieve some neuropathic pains but also produce disturbances of cognition and mood."5.08Intravenous infusion of the NMDA antagonist, ketamine, in chronic posttraumatic pain with allodynia: a double-blind comparison to alfentanil and placebo. ( Bennett, GJ; Byas-Smith, MG; Gracely, RH; Max, MB, 1995)
"Ketamine has been administered epidurally and intrathecally for operative and post-operative pain control."5.08Intrathecal ketamine reduces morphine requirements in patients with terminal cancer pain. ( Chang, JY; Ho, ST; Wong, CS; Yang, CY, 1996)
"Ten patients (4 female, 6 male) aged 34-67 years suffering from peripheral neuropathic pain participated in a double-blind placebo-controlled study where ketamine or magnesium chloride were administered by a 10 min bolus infusion (ketamine: 0."5.08NMDA receptor blockade in chronic neuropathic pain: a comparison of ketamine and magnesium chloride. ( Arendt-Nielsen, L; Felsby, S; Jensen, TS; Nielsen, J, 1996)
"Ketamine-a clinical available NMDA receptor antagonist-was administered intravenously to a patient with established stump pain in a double-blind saline-controlled fashion."5.08Oral ketamine therapy in the treatment of postamputation stump pain. ( Hansen, PO; Jensen, TS; Nikolajsen, L, 1997)
"In an attempt to clarify the neurochemical background of central post-stroke pain and to undertake a pharmacological analysis, the basic pharmacological characteristics of this intractable pain syndrome were investigated by the morphine, thiamylal and ketamine tests."5.08Pharmacological classification of central post-stroke pain: comparison with the results of chronic motor cortex stimulation therapy. ( Hirayama, T; Katayama, Y; Tsubokawa, T; Yamamoto, T, 1997)
"9% saline (1 ml) on propofol injection pain."5.08The effect of ketamine pretreatment on propofol injection pain in 100 women. ( Kua, SW; Onsiong, MK; Tan, CH, 1998)
"In a double-blind, controlled trial, we administered doses of an opioid analgesic (alfentanil), an N-methyl-D-aspartate receptor antagonist (ketamine), or their combination to normal volunteers and found no advantage of the combination over a larger dose of either drug alone in relieving pain caused by painful chemical stimulation."5.08Analgesic and cognitive effects of intravenous ketamine-alfentanil combinations versus either drug alone after intradermal capsaicin in normal subjects. ( Bennett, GJ; Gracely, R; Liu, M; Max, MB; Sethna, NF, 1998)
" This study examined the analgesic effect of local ketamine infiltration, compared with placebo and systemic ketamine, in a human model of inflammatory pain."5.08Peripheral analgesic effects of ketamine in acute inflammatory pain. ( Galle, TS; Kehlet, H; Pedersen, JL, 1998)
"Ketamine in sub-dissociative doses has been shown to have analgesic effects in various pain conditions, including neuropathic and phantom-limb pain, where conventional treatment has often failed."5.08The analgesic effect of racemic ketamine in patients with chronic ischemic pain due to lower extremity arteriosclerosis obliterans. ( Gustafsson, LL; Hasselström, J; Heller, A; Persson, J; Svensson, JO; Wiklund, B, 1998)
"The analgesic efficiency of ketamine and pethidine was compared in experimental ischemic pain and postoperative pain after oral surgery."5.06Comparison of ketamine and pethidine in experimental and postoperative pain. ( Hustveit, O; Maurset, A; Skoglund, LA; Øye, I, 1989)
"Intravenous ketamine is commonly used for pain management in the civilian prehospital setting."5.05Use of ketamine for prehospital pain control on the battlefield: A systematic review. ( Cauet, A; de Rocquigny, G; Dubecq, C; Martinez, T; Pasquier, P; Peffer, J; Travers, S, 2020)
" We present this case of a 34-year-old female patient who suffered an 18% total body surface area burn during the third trimester of pregnancy to demonstrate that ketamine can be considered as an adjunct for procedural and background analgesia during the third trimester, as part of a multimodal strategy in a short-term, monitored setting after a thorough and complete analysis of risks and benefits and careful patient selection."5.05Meeting the Challenge of Analgesia in a Pregnant Woman With Burn Injury Using Subanesthetic Ketamine: A Case Report and Literature Review. ( Elkhashab, Y; Hughes, LP; Hughes, MK; Hughes, WB; Roy, AB; Schwenk, ES; Viscusi, ER; West, LA, 2020)
" Ketamine, a N-methyl D-aspartate (NMDA) receptor antagonist, has been commonly used in the prehospital setting, including recommendations by the US Department of Defense and by the Royal Australian College of Pain Medicine, despite the paucity of high-level evidence."5.05Ketamine as a Prehospital Analgesic: A Systematic Review. ( Bansal, A; Burns, B; Ferguson, I; Miller, M, 2020)
"Ketamine is regaining popularity in the field of anesthesia and beyond."5.05Ketamine: a versatile tool for anesthesia and analgesia. ( Barrett, W; Buxhoeveden, M; Dhillon, S, 2020)
"Subanesthetic ketamine doses rapidly, albeit transiently decrease suicidal ideation, with effects emerging within an hour and persisting up to a week."5.01Suicide Has Many Faces, So Does Ketamine: a Narrative Review on Ketamine's Antisuicidal Actions. ( Courtet, P; Lengvenyte, A; Olié, E, 2019)
"Low-dose ketamine infusions for pediatric patients with sickle cell disease painful crises resulted in improved pain scores and reduced opioid usage."5.01Ketamine Infusion for Pain Control in Acute Pediatric Sickle Cell Painful Crises. ( Hagedorn, JM; Monico, EC, 2019)
"In this review, we examined basic mechanisms of ketamine and its current clinical use and potential novel use in pain management."4.98An Update on the Basic and Clinical Science of Ketamine Analgesia. ( Doan, LV; Wang, J, 2018)
"The purpose of this review is to integrate a number of basic science, preclinical, and clinical studies with the goal of providing insight into the possible signaling events underlying ketamine's biological effects in pain management, depression, cognition and memory, and neurodevelopment."4.95Ketamine: An Update on Cellular and Subcellular Mechanisms with Implications for Clinical Practice. ( Iacobucci, GJ; Nader, ND; Pourafkari, L; Visnjevac, O, 2017)
" All randomized controlled trials that using lidocaine for propofol injection pain in children were enrolled."4.95Efficacy of lidocaine on preventing incidence and severity of pain associated with propofol using in pediatric patients: A PRISMA-compliant meta-analysis of randomized controlled trials. ( Fu, YZ; Lang, BC; Yang, CS; Zhang, LL; Zhang, WS, 2017)
"After nearly half a century on the market, ketamine still occupies a unique corner in the medical armamentarium of anesthesiologists or clinicians treating pain."4.93Ketamine use in current clinical practice. ( Gao, M; Liu, H; Rejaei, D, 2016)
"This article reports a rare case of the use of low-dose ketamine infusion as an adjuvant to opioids to treat pain in sickle cell disease."4.90Ketamine infusion for sickle cell pain crisis refractory to opioids: a case report and review of literature. ( Baber, A; Foy, M; Uprety, D, 2014)
"The role of ketamine anesthesia in the prehospital, emergency department and operating theater settings is not well defined."4.89Ketamine: use in anesthesia. ( Andolfatto, G; Brandner, B; Ellerton, J; Marland, S; Paal, P; Strapazzon, G; Thomassen, O; Weatherall, A, 2013)
"For ketamine's fiftieth birthday, a narrative review of this unique drug in pain management is presented."4.89Ketamine in pain management. ( Persson, J, 2013)
" Ketamine is a commonly used anaesthetic agent, and in subanaesthetic doses is also given as an adjuvant to opioids for the treatment of cancer pain, particularly when opioids alone prove to be ineffective."4.88Ketamine as an adjuvant to opioids for cancer pain. ( Bell, RF; Eccleston, C; Kalso, EA, 2012)
"To assess the current literature regarding the effectiveness and side-effect profile of intravenous ketamine as a means of pain relief when compared with placebo or as an adjunct to opioid analgesia in patients exposed to burn injury."4.87A systematic review of ketamine as an analgesic agent in adult burn injuries. ( Cleland, H; Hogan, L; Hucker, T; Mahar, PD; McGuinness, SK; Symons, J; Wasiak, J, 2011)
"While most studies on intravenous ketamine show acute analgesic effects, three recent trials on long-term ketamine treatment (days to weeks) demonstrate the effectiveness of ketamine in causing long-term (months) relief of chronic pain."4.86Ketamine for the treatment of chronic non-cancer pain. ( Aarts, L; Dahan, A; Niesters, M; Noppers, I; Sarton, E; Smith, T, 2010)
"Multimodal therapy encompasses a wide range of procedures and medications, including regional analgesia with continuous epidural or peripheral nerve block infusions, judicious opioids, acetaminophen, anti-inflammatory agents, anticonvulsants, ketamine, clonidine, mexiletine, antidepressants, and anxiolytics as options to treat or modulate pain at various sites of action."4.84The evolution of pain management in the critically ill trauma patient: Emerging concepts from the global war on terrorism. ( Black, IH; Malchow, RJ, 2008)
" Alternative approaches with methadone, ketamine, or local anesthetics should be considered."4.84Pharmacological approaches to the management of pain in the neonatal intensive care unit. ( Anand, KJ, 2007)
" Search terms included analgesia, cancer pain, dextromethorphan, hospice, ketamine, opioids, palliative care, neuropathic pain, and morphine."4.83The potential role of ketamine in hospice analgesia: a literature review. ( Ball, N; Elliott, DP; Legge, J, 2006)
"Ketamine is a commonly used anaesthetic agent, and in subanaesthetic doses is also given as an adjuvant to opioids for the treatment of cancer pain, particularly when opioids alone prove to be ineffective."4.82Ketamine as an adjuvant to opioids for cancer pain. ( Bell, R; Eccleston, C; Kalso, E, 2003)
"Ketamine is increasingly being used as an adjuvant to opioids in the treatment of refractory cancer pain."4.82Ketamine as adjuvant to opioids for cancer pain. A qualitative systematic review. ( Bell, RF; Eccleston, C; Kalso, E, 2003)
"Ketamine has diverse effects that may be of relevance to chronic pain including: N-methyl-D-aspartic acid, alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid, kainate, gamma-aminobutyric acid(A) receptors; inhibition of voltage gated Na(+) and K(+) channels and serotonin, dopamine re-uptake."4.82Ketamine in chronic pain management: an evidence-based review. ( Cousins, MJ; Hocking, G, 2003)
" Evidence presented in this review shows encouraging results following the administration of methadone, fentanyl or ketamine to patients with difficult pain problems."4.82Morphine is not the only analgesic in palliative care: literature review. ( Wootton, M, 2004)
"Ketamine is an effective analgesic agent for treating a variety of neuropathic and cancer pain syndromes."4.82Parenteral ketamine as an analgesic adjuvant for severe pain: development and retrospective audit of a protocol for a palliative care unit. ( Fitzgibbon, EJ; Viola, R, 2005)
"To review the clinical literature evaluating the utilization of intravenous ketamine for the management of cancer-related pain, to summarize the data that suggest ketamine is an appropriate adjuvant method of providing analgesia and to report a case of successful pain management using ketamine in a patient with recurrent testicular cancer at our institution."4.81Adjuvant ketamine analgesia for the management of cancer pain. ( Baroletti, SA; McQueen, AL, 2002)
" In the majority of clinical studies addressing this issue, ketamine, which has NMDA antagonist properties, has been found to reduce the need for opiates for the treatment of severe pain conditions."4.80Combined opioid-NMDA antagonist therapies. What advantages do they offer for the control of pain syndromes? ( Wiesenfeld-Hallin, Z, 1998)
"We report the initial seven patients treated with nebulized ketamine for moderate to severe pain, via breath-actuated nebulizer, in an urban, ground-based emergency medical services (EMS) system."4.31Nebulized Ketamine for Analgesia in the Prehospital Setting: A Case Series. ( De La Rosa, X; Patrick, C; Rafique, Z; Rogers Keene, K; Smith, M, 2023)
"Ketamine infusions are frequently employed for refractory complex regional pain syndrome (CRPS), but there are limited data on factors associated with treatment response."4.31Sympathetic Blocks as a Predictor for Response to Ketamine Infusion in Patients with Complex Regional Pain Syndrome: A Multicenter Study. ( Cheng, J; Cohen, SJ; Cohen, SP; Khunsriraksakul, C; Moon, JY; Parker, E; Patel, N; Samen-Akinsiku, CDK; Yoo, Y; Yuan, X, 2023)
"Depressive symptom severity and the affective index of pain partially mediated improvements in social function after six repeated ketamine treatments among patients with bipolar or unipolar depressive disorder."4.31Pain mediates the improvement of social functions of repeated intravenous ketamine in patients with unipolar and bipolar depression. ( Gan, Y; Hu, Z; Lan, X; Li, N; Li, W; Liu, H; Ning, Y; Wang, C; Wu, Z; Ye, Y; Zhang, F; Zhou, Y, 2023)
"Outcomes were the recording of a pain score and the administration of a nonoral opioid or ketamine."4.31Race and Ethnicity and Prehospital Use of Opioid or Ketamine Analgesia in Acute Traumatic Injury. ( Brunson, DC; Carrillo, E; Matheson, LW; Miller, KA, 2023)
"Intrathecal 2R, 6R-HNK, rather than intraperitoneal 2R, 6R-HNK or intrathecal S-Ketamine, successfully mitigated HFS-induced pain."4.31The potent analgesia of intrathecal 2R, 6R-HNK via TRPA1 inhibition in LF-PENS-induced chronic primary pain model. ( Feng, X; Li, Y; Lin, ZJ; Liu, AR; Peng, XG; Tan, Z; Tang, Y; Wei, M; Zhang, H; Zheng, YF; Zhou, LJ, 2023)
"Following recognition of opioid induced hyperalgesia, the patient was managed with opioid rotation and ketamine, which resulted in prompt alleviation of pain."4.12Role of Ketamine and Opioid Rotation in the Management of Opioid Induced Hyperalgesia in a Patient With Acute Promyelocytic Leukemia. ( Akhtari, M; Cao, H; Hino, C; Ran-Castillo, D; Silvestre, J, 2022)
"The objective of our study was to determine safety and pharmacology (pharmacokinetics and preliminary efficacy) of intranasal (IN) ketamine for uncontrolled cancer-related pain."4.12A dose-escalation clinical trial of intranasal ketamine for uncontrolled cancer-related pain. ( Beumer, JH; Curseen, K; Egan, K; Gillespie, TW; Harvey, RD; Lane, O; Shteamer, JW; Singh, V; Sniecinski, R; Spektor, B; Switchenko, J; Tsvetkova, M; Zarrabi, AJ, 2022)
"To report on an unusual case of ketamine-precipitated syndrome of inappropriate antidiuretic hormone secretion (SIADH) in an individual managed by an outpatient pain specialty team."4.12Ketamine-precipitated syndrome of inappropriate antidiuretic hormone secretion in a patient with persistent lumbar pain: a case report. ( Lau, A; van Bockxmeer, JJ; Varshney, V, 2022)
"Psychological pain and hopelessness were not associated with the re-emergence of SI post-ketamine."4.12Prospective association of psychological pain and hopelessness with suicidal thoughts. ( Ballard, ED; Bloomfield-Clagett, B; Farmer, CA; Gerner, J; Park, LT; Zarate, CA, 2022)
"Our aim was to evaluate the quality and safety of procedural sedation using the combination of dexmedetomidine and ketamine for patients undergoing painful procedures in the emergency department."4.12Procedural Sedation With Dexmedetomidine in Combination With Ketamine in the Emergency Department. ( Cren, R; De Kock, M; Grégoire, C; Henrie, J; Lavand'homme, P; Penaloza, A; Verschuren, F, 2022)
" Inclusion criteria were 16 years or older, two or more documented pain assessments, at least one indicating severe pain, and administration of opioids and/or low-dose ketamine."4.12Opioid sparing effect of ketamine in military prehospital pain management-A retrospective study. ( Avital, G; Benov, A; Cohen, B; Gelikas, S; Kontorovich-Chen, D; Radomislensky, I; Talmy, T, 2022)
"This article provides a comprehensive discussion of ketamine's pharmacological properties, safety profile, and an overview of current evidence for ketamine in the management of ED patients with acute agitation, pain, depression/suicide ideation."4.12Novel uses of ketamine in the emergency department. ( Corwell, BN; Davis, NL; Kim, HK; Motov, SM, 2022)
" His pain and agitation were difficult to manage but improved after he received ketamine."4.12Suspected opioid-induced hyperalgesia in an infant following surgery: A case report. ( Efune, PN; Rebstock, SE, 2022)
" However, to the best of our knowledge, no study has reported on endotracheal intubation without the use of muscle relaxants under anesthetic management with remimazolam, nor on the combination of remimazolam and ketamine."4.12Effective anesthetic management with remimazolam and ketamine without muscle relaxants for parotidectomy in a patient with myotonic dystrophy: A case report. ( Habu, MI; Ishida, Y; Toba, Y, 2022)
" Additionally, dissociative sedation ketamine for severe agitation/excited delirium led to less endotracheal intubation than reported in the prehospital literature."3.96Ketamine Safety and Use in the Emergency Department for Pain and Agitation/Delirium: A Health System Experience. ( Campbell, MJ; Casserly, E; Fertel, BS; Lam, SW; Meldon, SW; Mo, H; Wells, EJ, 2020)
"Sprague-Dawley rats (11-13 weeks) were randomly assigned to control (saline vehicle), fentanyl, or ketamine-treated groups with or without hemorrhage (n = 8 or 9 for each group)."3.96Fentanyl impairs but ketamine preserves the microcirculatory response to hemorrhage. ( Calderon, AS; Hinojosa-Laborde, C; Klemcke, HG; Ryan, KL; Scott, LL; Xiang, L, 2020)
" Ketamine can quickly relieve depression, and its subcutaneous administration appears to be as effective as and probably safer than its standard intravenous administration."3.96Repeated subcutaneous esketamine administration for depressive symptoms and pain relief in a terminally ill cancer patient: A case report. ( Barbosa, MG; Delfino, RS; Jackowski, AP; Sarin, LM, 2020)
"Low doses of ketamine have been shown to be safe and effective for pain relief."3.96Transient amnesia following prehospital low-dose ketamine administration. ( Aljadeed, R; Perona, S, 2020)
" Ketamine is on the WHO's list of essential medications and is used for a variety of pharmacologic applications including anesthesia and acute pain management."3.96Ketamine for pain control of snake envenomation in Guinea: A case series. ( Balde, C; Benjamin, JM; Brandehoff, N; Chippaux, JP, 2020)
"Ketamine is beneficial in clinical settings ranging from procedural sedation to the treatment of chronic pain."3.96Ketamine for Acute Pain Management and Sedation. ( Brown, K; Tucker, C, 2020)
"The results of the present study suggest that serotonergic and opioidergic systems are involved, at least in part, in the antinociceptive effect of the ketamine-magnesium sulphate combination in the model of inflammatory pain in rats."3.91Involvement of serotonergic and opioidergic systems in the antinociceptive effect of ketamine-magnesium sulphate combination in formalin test in rats. ( Divac, N; Medić, B; Prostran, M; Savić Vujović, K; Srebro, D; Stojanović, R; Vasović, D; Vučković, S, 2019)
"Ketamine is a drug largely used in clinical practice as an anesthetic and it can also be used as an analgesic to manage chronic pain symptoms."3.91Peripheral antinociception induced by ketamine is mediated by the endogenous opioid system. ( Caliari, MV; de Almeida, DL; Duarte, IDG; Lima Romero, TR; Paiva-Lima, P; Petrocchi, JA; Queiroz-Junior, C, 2019)
" Ketamine, acknowledged for its versatility and safety profile, remains a critical component in the medical arsenal of anaesthesiologists and clinicians treating both acute and chronic pain."3.91The ketamine crisis: Does South Africa have a plan B? ( Bangalee, V; Wall, S, 2019)
"Therapeutic interventions for neuropathic pain, such as the N-methyl-D-aspartate (NMDA) antagonist ketamine, can vary widely in effectiveness."3.91Plasticity in the dynamic pain connectome associated with ketamine-induced neuropathic pain relief. ( Bhatia, A; Bosma, RL; Cheng, JC; Davis, KD; Hemington, KS; Kim, JA; Osborne, NR; Rogachov, A; Venkatraghavan, L, 2019)
"To examine the analgesic effects of adjuvant ketamine on pain scale scores in trauma intensive care unit (ICU) rib fracture."3.88Ketamine as an Analgesic Adjuvant in Adult Trauma Intensive Care Unit Patients With Rib Fracture. ( Bischoff, J; Evans, C; Farhat, J; Foss, M; Walters, MK, 2018)
"Although ketamine analgesia is effective in reducing pain and facilitating the tracheal intubation of newborns in the delivery room, no data on the neurological effects of this treatment are available."3.88Prospective follow-up of a cohort of preterm infants<33 WG receiving ketamine for tracheal intubation in the delivery room: Neurological outcome at 1 and 2 years. ( Elalouf, C; Fontaine, C; Gondry, J; Kongolo, G; Le Moing, AG; Leke, A; Tourneux, P, 2018)
"Our objective was to describe dosing, duration, and pre- and post-infusion analgesic administration of continuous intravenous sub-dissociative dose ketamine (SDK) infusion for managing a variety of painful conditions in the emergency department (ED)."3.88Continuous Intravenous Sub-Dissociative Dose Ketamine Infusion for Managing Pain in the Emergency Department. ( Beals, T; Drapkin, J; Fromm, C; Likourezos, A; Marshall, J; Monfort, R; Motov, S, 2018)
"WHAT THIS ARTICLE TELLS US THAT IS NEW: BACKGROUND:: Ketamine is an N-methyl-D-aspartate receptor antagonist that reduces temporal summation of pain and modulates antinociception."3.88Brain Dynamics and Temporal Summation of Pain Predicts Neuropathic Pain Relief from Ketamine Infusion. ( Bhatia, A; Bosma, RL; Cheng, JC; Davis, KD; Hemington, KS; Kim, JA; Osborne, NR; Rogachov, A; Venkat Raghavan, L, 2018)
"The study evaluated the effect of intra-articular injections of ketamine and 25% dextrose with triamcinolone acetate (TA) and hyaluronic acid (HA) on joint pathology and pain behavior in monosodium iodoacetate (MIA)-induced osteoarthritis (OA) in experimental mice."3.85Intra-articular injections of ketamine and 25% dextrose improve clinical and pathological outcomes in the monosodium iodoacetate model of osteoarthritis. ( Brahma, S; Jalgaonkar, SV; Koli, PG; Kshirsagar, S; Patil, AE; Rege, NN; Salgaonkar, S; Shetty, YC; Teltumbde, PA, 2017)
"Because ketamine and magnesium block NMDA receptor activation by distinct mechanisms of action, we hypothesized that in a model of inflammatory pain in rats the combination of ketamine and magnesium might be more effective than ketamine alone."3.85Additive and antagonistic antinociceptive interactions between magnesium sulfate and ketamine in the rat formalin test. ( Knežević, N; Medić, B; Prostran, M; Vasović, D; Vučković, S; Vujović, KS, 2017)
"We report a case series on the observed effects of low-dose ketamine infusions in 4 critically ill patients with varying complications related to prolonged critical illness."3.83Low-Dose Ketamine in Chronic Critical Illness. ( Darrah, D; Moitra, A; Moitra, VK; Patel, MK; Wunsch, H, 2016)
"This study compared effects of the NMDA receptor antagonists ketamine and MK-801 in assays of pain-stimulated and pain-depressed behaviour in rats."3.83Effects of the noncompetitive N-methyl-d-aspartate receptor antagonists ketamine and MK-801 on pain-stimulated and pain-depressed behaviour in rats. ( Hillhouse, TM; Negus, SS, 2016)
"Changes in visual analog scale (VAS) scores for pain following pharmacological evaluation using morphine, thiopental, and ketamine were compared with those following SCS in 22 CPSP patients."3.83Importance of Pharmacological Evaluation in the Treatment of Poststroke Pain by Spinal Cord Stimulation. ( Fukaya, C; Kano, T; Kobayashi, K; Obuchi, T; Oshima, H; Watanabe, M; Yamamoto, T; Yoshino, A, 2016)
"Intravenous ketamine treatment is frequently used for the management of chronic pain, especially in those patients who do not benefit from other therapies."3.83[Safety and efficacy of ketamine for pain relief]. ( Dahan, A; Niesters, M; van Kleef, M, 2016)
"Immunoglobulin E, ketamine cystitis, interstitial cystitis."3.83The Role of Immunoglobulin E in the Pathogenesis of Ketamine Related Cystitis and Ulcerative Interstitial Cystitis: An Immunohistochemical Study. ( Hsu, YH; Jhang, JF; Jiang, YH; Kuo, HC, 2016)
"The objective of this systematic review is to examine the best available evidence on the clinical effectiveness of ketamine as an adjuvant to opioid-based therapy versus opioid-based therapy alone in decreasing perioperative pain associated with opioid tolerance in adult patients, aged 18-70 years, undergoing orthopedic surgical procedures."3.83Effectiveness of ketamine as an adjuvant to opioid-based therapy in decreasing pain associated with opioid tolerance in adults undergoing orthopedic surgery: a systematic review protocol. ( Bennett, M; Bonanno, L; Kuhn, W, 2016)
"A low-dose ketamine infusion protocol provided significant pain relief with mostly mild side effects and no severe adverse events."3.81Low-Dose Ketamine Infusion for Emergency Department Patients with Severe Pain. ( Ahern, TL; Frazee, BW; Herring, AA; Miller, S, 2015)
"Midazolam and ketamine were administered consecutively by intravenous route under cardiorespiratory monitoring for painful procedures of pediatric hematology."3.81The Efficacy and Safety of Procedural Sedoanalgesia with Midazolam and Ketamine in Pediatric Hematology. ( Çakmak, E; Demirsoy, U; Gelen, SA; Sarper, N; Zengin, E, 2015)
"This study revealed that (1) magnesium sulphate and ketamine given alone were not effective against acute nociceptive pain in rats, but (2) a combination of both drugs resulted in synergistically inhibited nociception, (3) which occurred only at selected low doses and proportions of the medications in a combination and (4) suggested the importance of the order of drug administration."3.81A synergistic interaction between magnesium sulphate and ketamine on the inhibition of acute nociception in rats. ( Medic, B; Prostran, M; Savic Vujovic, KR; Srebro, D; Stojanovic, R; Vucetic, C; Vuckovic, S, 2015)
"Before updating the French guidelines on postoperative pain treatment in 2015, the Pain Committee of the French Society of Anaesthesiology and Intensive Care (SFAR) conducted a survey on the medical use of ketamine in France."3.81Ketamine for pain management in France, an observational survey. ( Beloeil, H; Derivaux, B; Martinez, V, 2015)
"We studied the role of a low-dose intravenous (IV) ketamine-midazolam combination in the management of severe painful sickle cell crisis."3.80The role of a low-dose ketamine-midazolam regimen in the management of severe painful crisis in patients with sickle cell disease. ( Faris, AS; Kausalya, R; Tawfic, QA, 2014)
"Ketamine, a noncompetitive N-methyl-D-aspartate receptor antagonist, has been used for the treatment of cancer pain as an analgesic adjuvant to opioids."3.80Subanalgesic ketamine enhances morphine-induced antinociceptive activity without cortical dysfunction in rats. ( Goda, Y; Goto, Y; Hiraide, S; Kamiyama, H; Kiya, T; Oda, K; Shikanai, H; Shimamura, K; Togashi, H; Yanagawa, Y, 2014)
"In this retrospective study, the medical records of 50 patients hospitalized on medical and surgical units at our facility who had continuous intravenous infusions of ketamine for pain or mild sedation were reviewed."3.80Psychiatric side effects of ketamine in hospitalized medical patients administered subanesthetic doses for pain control. ( Rasmussen, KG, 2014)
"Examine response patterns to low-dose intravenous (IV) ketamine continuous infusions on multiple pain outcomes, and demonstrate effectiveness, safety, and tolerability of ketamine administration on general wards."3.79Effects of low-dose IV ketamine on peripheral and central pain from major limb injuries sustained in combat. ( Buckenmaier, CC; Gallagher, RM; Goldberg, C; Hanlon, AL; Kwon, KH; Polomano, RC; Rupprecht, C, 2013)
"Ketamine 100 ng/ml exerts its effect on pain related brain regions."3.79[Effect of subanaesthetic dose of ketamine on mechanical stimulus on brain regions]. ( Sun, L; Wang, HY; Xu, L; Ye, TH; Yuan, H; Zou, L, 2013)
"Low-dose ketamine may decrease patients' perception of pain."3.79Low-dose ketamine analgesia: patient and physician experience in the ED. ( Richards, JR; Rockford, RE, 2013)
"We report the successful use of low-dose ketamine infusion for treating a severe episode of painful myoclonus in the lower extremities, associated with opioid-induced hyperalgesia (OIH), in a patient who was receiving long-term, high dose intrathecal hydromorphone therapy."3.78Successful reversal of hyperalgesia/myoclonus complex with low-dose ketamine infusion. ( Chan, PS; Forero, M; Restrepo-Garces, CE, 2012)
"Injection anaesthesia with a combination of ketamine and azaperone (K/A) is discussed as a painless alternative to commonly used non-anaesthetized castration."3.78Impact of general injection anaesthesia and analgesia on post-castration behaviour and teat order of piglets. ( König, A; Schmidt, T; von Borell, E, 2012)
"In 24/92 (26%) of cases, morphine PCA provided insufficient pain relief and children required adjuvant ketamine therapy."3.77Pain management in 100 episodes of severe mucositis in children. ( Hommers, C; Parry, S; Stoddart, PA; White, MC, 2011)
"The ketamine pharmacokinetics in children with minor burns are similar to those without burns."3.77Exploring the pharmacokinetics of oral ketamine in children undergoing burns procedures. ( Anderson, BJ; Brunette, KE; Herd, DW; Schulein, S; Thomas, J; Wiesner, L, 2011)
"To investigate the expression of protein kinase C (PKC) in the spinal dorsal horn of rats with formalin-induced pain and the effect of intrathecal ketamine on PKC expression."3.77[Effect of intrathecal ketamine injection on protein kinase C expression in the spinal dorsal horn of rats with formalin-induced pain]. ( GUO, QL; WANG, E; YAN, JQ; YANG, Y; ZOU, WY, 2011)
"Compared to ketamine + no VR, both patients reported less pain during ketamine + VR for all three pain ratings."3.77Combining ketamine and virtual reality pain control during severe burn wound care: one military and one civilian patient. ( Desocio, PA; Fowler, M; Gaylord, KM; Hoffman, HG; Maani, CV; Maiers, AJ, 2011)
"We investigated the heat pain threshold (HPT) and temporal summation threshold (TST) before and after target-controlled infusion (TCI) of ketamine with an effect-site concentration (Ce) of 30 and 60 ng/ml."3.77The effect of target-controlled infusion of low-dose ketamine on heat pain and temporal summation threshold. ( Chae, WS; Cho, SH; Jin, HC; Kim, SH; Kim, YI; Lee, JH; Lee, JS, 2011)
"Ketamine, its active metabolite norketamine, and the NR2B-selective antagonist traxoprodil (CP-101,606) were tested in rat models of acute antinociception (paw-withdrawal response to heat) and chronic neuropathic pain (spared nerve injury)."3.77Nonselective and NR2B-selective N-methyl-D-aspartic acid receptor antagonists produce antinociception and long-term relief of allodynia in acute and neuropathic pain. ( Aarts, L; Dahan, A; Morariu, A; Niesters, M; Swartjes, M, 2011)
"The aim of the study was to explore the analgesic effect of the N-methyl-d-aspartate receptor (NMDAR) antagonist ketamine in acute experimental versus chronic spontaneous pain in Complex Regional Pain Syndrome type 1 (CRPS-1) patients."3.76An observational study on the effect of S+-ketamine on chronic pain versus experimental acute pain in Complex Regional Pain Syndrome type 1 patients. ( Bauer, M; Dahan, A; Mooren, R; Noppers, I; Olofsen, E; Sarton, E; Sigtermans, M, 2010)
"Five children and adolescents received a low-dose ketamine infusion for the treatment of sickle cell-related pain."3.76Use of low-dose ketamine infusion for pediatric patients with sickle cell disease-related pain: a case series. ( Corsi, JM; Hagstrom, JN; Loiselle, KA; Zempsky, WT, 2010)
"Ketamine abusers frequently presented with upper GI symptoms, the commonest of which is epigastric pain (73% of abusers)."3.76Upper gastrointestinal problems in inhalational ketamine abusers. ( Chan, MY; Chu, SK; Fung, KW; Leung, SK; Man, CW; Poon, TL; Wong, KF; Yiu, MK, 2010)
"To assess the efficacy of adding ketamine to morphine nurse- or patient-controlled analgesia (NCA/PCA) infusions in treating mucositis pain in children."3.76The addition of ketamine to a morphine nurse- or patient-controlled analgesia infusion (PCA/NCA) increases analgesic efficacy in children with mucositis pain. ( Howard, RF; James, PJ; Williams, DG, 2010)
"The ketamine (ket) model reflects features of schizophrenia as well as secondary symptoms such as altered pain sensitivity."3.75Haloperidol and risperidone have specific effects on altered pain sensitivity in the ketamine model of schizophrenia. ( Becker, A; Grecksch, G; Hiemke, C; Ladstaetter, E; Schmitt, U; Zernig, G, 2009)
"Although ketamine is widely used as an analgesic agent and has an anti-allodynic effect on neuropathic pain, the underlying analgesic mechanisms are not fully explained by the modern 'neuronal-based' theories."3.75Inhibiting astrocytic activation: a novel analgesic mechanism of ketamine at the spinal level? ( Li, Y; Mei, X; Wang, W; Wu, S; Xu, L; Zhang, H, 2009)
"The purpose of this study was to examine possible peripheral mechanisms for the reduction of propofol injection pain by the addition of ketamine."3.75Preventing pain on injection of propofol: a comparison between peripheral ketamine pre-treatment and ketamine added to propofol. ( Do, SH; Hwang, J; Jeon, YT; Lee, SC; Lim, YJ; Park, HP, 2009)
"To improve opioid repsonse in patients with movement-related pain by using opioid switching adding a burst of ketamine."3.75Opioid switching and burst ketamine to improve the opioid response in patients with movement-related pain due to bone metastases. ( Arcuri, E; David, F; Ferrera, P; Mercadante, S; Villari, P, 2009)
"Our objective was to determine if an oral ketamine swish and expectorate was a safe and effective method to alleviate mucositis pain."3.75Ketamine mouthwash for mucositis pain. ( Atayee, RS; Lin, F; Ryan, AJ, 2009)
"Low-dose ketamine behaves as an analgesic in the treatment of acute and chronic pain."3.75S(+)-ketamine effect on experimental pain and cardiac output: a population pharmacokinetic-pharmacodynamic modeling study in healthy volunteers. ( Bauer, M; Dahan, A; Kest, B; Mooren, R; Olofsen, E; Sarton, E; Sigtermans, M, 2009)
" Since 2005 to 2007, we evaluated the safety and efficacy of ketamine to control pain induced by diagnostic procedures in pediatric oncology patients."3.75[Sedation using ketamine for pain procedures in Pediatric Oncology.]. ( Bernard, F; Ricard, C; Tichit, R; Troncin, R, 2009)
" In the present study, morphine (a low dose) was combined with S(+)- and R(-)-norketamine (sub-antinociceptive doses) and characterized utilizing rodent models of pain including: thermal nociception (the tail-flick test), peripheral neuropathy (chronic constriction nerve injury) and tonic inflammatory pain (the formalin test)."3.74Interaction between morphine and norketamine enantiomers in rodent models of nociception. ( Crooks, PA; Holtman, JR; Johnson-Hardy, J; Wala, EP, 2008)
" The topics addressed are tolerance to opioid side effects, use of botulinum toxin A in pain management, and the use of ketamine in pain management."3.74European pain management discussion forum. ( Eisenberg, E, 2008)
" infusion of propofol, or propofol plus ketamine for deep sedation and analgesia was carried out in two patients with severe epidermolysis bullosa (EB) during extensive dressing changes and deep whirlpool baths."3.74Deep sedation with intravenous infusion of combined propofol and ketamine during dressing changes and whirlpool bath in patients with severe epidermolysis bullosa. ( Wu, J, 2007)
"We report the use of an intravenous ketamine infusion for 37 days in a 9-year-old child with 42% body surface area burns."3.74Long-term use of an intravenous ketamine infusion in a child with significant burns. ( Karsli, C; White, MC, 2007)
"This prospective audit was undertaken in order to document the analgesic response and adverse effects of concurrent short-term ('burst') triple-agent analgesic (ketamine, an opioid and an anti-inflammatory agent--either steroidal or non-steroidal) administration, for episodes of acute on chronic pain."3.73Prospective audit of short-term concurrent ketamine, opioid and anti-inflammatory ('triple-agent') therapy for episodes of acute on chronic pain. ( Ashby, M; Good, P; Goodchild, C; Jackson, K; Tullio, F, 2005)
"Pretreatment with intravenous ketamine inhibits inflammatory pain behavior and FLI expression following a formalin injection in rats, suggesting that pretreatment of ketamine plays an important role in preemptive analgesia."3.73Preemptive effect of intravenous ketamine in the rat: concordance between pain behavior and spinal fos-like immunoreactivity. ( Lee, IH; Lee, IO, 2005)
"Questions have been raised about the potential neurotoxicity of the neuraxial use of ketamine although ketamine and its active enantiomer S(+)-ketamine have been used intrathecally and epidurally (caudally) for the management of perioperative pain and in a variety of chronic pain syndromes."3.73Neuropathological findings after continuous intrathecal administration of S(+)-ketamine for the management of neuropathic cancer pain. ( Kruis, MR; Troost, D; van der Vegt, MH; Vranken, JH; Wegener, JT, 2005)
"The purpose of this study is to compare the sedation recovery times of children receiving ketamine/midazolam (K/M) versus K/M and initial pain treatment (morphine or meperidine) in pediatric emergency care."3.73Effects of initial pain treatment on sedation recovery time in pediatric emergency care. ( Losek, JD; Reid, S, 2006)
" A 58-year-old man with multiple arthritis of rheumatic arthritis and fibromyalgia had headache, nausea, and vomiting all day after ketamine test."3.73[Postponed or canceled drug challenge tests and side effects of the test drug--a report of four cases]. ( Ann, Y; Arita, H; Asahara, M; Hanaoka, K; Kawamura, G; Mizuno, J; Sekiyama, H, 2006)
"IV Midazolam and IV Ketamine were used for PSA in pediatric oncology patients undergoing painful procedures."3.73Safe and efficacious use of procedural sedation and analgesia by non-anesthesiologists in a pediatric hematology-oncology unit. ( Advani, SH; Ambulkar, I; Borker, A; Gopal, R, 2006)
" These address opioids for the management of breakthrough (episodic) pain in cancer patients, perioperative ketamine for acute postoperative pain, and superficial heat or cold for low back pain."3.73Evidence-based pain management and palliative care in Issue One for 2006 of The Cochrane Library. ( Wiffen, PJ, 2006)
" The aim of the study was to assess the effect of non-competitive NMDA antagonists and paracetamol (propacetamol) on pain threshold and analgesic potency of this drugs and their combinations in formalin model for pain in rats."3.73[Dextromethorphan enhances analgesic activity of propacetamol--experimental study]. ( Dobrogowski, J; Przewłocka, B; Wordliczek, J, 2005)
"We have demonstrated the safe and effective use of ketamine analgesia in children with toxic megacolon, a condition in which the child is in severe pain and morphine is contraindicated."3.73Pain management in fulminating ulcerative colitis. ( Lindley, K; Lloyd-Thomas, A; Shah, N; Thomas, M; White, M, 2006)
"To determine the proportion of emergency departments in the UK that use modern pharmacological methods of pain and anxiety control in children, such as analgesia with intranasal diamorphine, procedural sedation using ketamine or midazolam, and adrenaline-cocaine gel, TAC or LAT for anaesthetising wounds in children."3.73Consigning "brutacaine" to history: a survey of pharmacological techniques to facilitate painful procedures in children in emergency departments in the UK. ( Chavada, G; Coats, T; Davies, F; Loryman, B, 2006)
" The present study examined the effects of combinations of dextromethorphan and ketamine, two clinically used N-methyl-D-aspartate (NMDA) receptor antagonists, with amitriptyline on formalin-evoked behaviors and paw edema."3.72Peripheral interactions between dextromethorphan, ketamine and amitriptyline on formalin-evoked behaviors and paw edema in rats. ( Reid, A; Sawynok, J, 2003)
" In the first series of experiments, RT and VPL responses to pinching with a small artery clamp were tested with the rats under pentobarbital, urethane, ketamine, or halothane anesthesia."3.72Reticular thalamic responses to nociceptive inputs in anesthetized rats. ( Shaw, FZ; Yen, CT, 2003)
"Topically administered capsaicin produces thermal allodynia, and this effect has been used to investigate pain transduction and its pharmacological modulation."3.72Topical capsaicin-induced allodynia in unanesthetized primates: pharmacological modulation. ( Ball, JW; Butelman, ER; Harris, TJ; Kreek, MJ, 2003)
"8% used inhalants (particularly isoflurane) for anesthesia, and ketamine, propofol, and butorphanol were the most commonly used injectable agents."3.72Evaluation of the use of anesthesia and analgesia in reptiles. ( Read, MR, 2004)
" We investigated here the effects of ketamine anesthesia on somatosensory processing in the rat spinal cord, thalamus, and cerebral cortex, using the quantitative 2-deoxyglucose mapping technique."3.72Effects of ketamine anesthesia on central nociceptive processing in the rat: a 2-deoxyglucose study. ( Baraldi, P; Cavazzuti, M; Giuliani, D; Lui, F; Porro, CA; Vellani, V, 2004)
"To determine whether intraarticular pretreatment with N-methyl-D-aspartic (NMDA) receptor antagonist ketamine or memantine currently used in humans has prophylactic analgesia in arthritic pain, we examined the effects of their intraarticular injection before carrageenan injection into the knee joint on pain-related behavior and spinal c-Fos expression in rats."3.72Intraarticular pretreatment with ketamine and memantine could prevent arthritic pain: relevance to the decrease of spinal c-fos expression in rats. ( Back, SK; Han, HC; Hong, SK; Kim, YI; Lee, KS; Min, SS; Na, HS; Yoon, SJ; Yoon, YW; Zhang, GH, 2004)
") administration of 200mg/kg cyclophosphamide, an antitumoral agent, modified the behaviour of rats with cystitis induced by acrolein, a toxic urinary by-product of cyclophosphamide."3.71Involvement of N-methyl-D-aspartate receptors in nociception in the cyclophosphamide-induced vesical pain model in the conscious rat. ( Boucher, M; Coudoré-Civiale, MA; Eschalier, A; Méen, M; Parry, L, 2002)
"We describe an opioid-tolerant patient with severe acute pain which was unrelieved by morphine and ketamine via intravenous patient-controlled analgesia, but almost totally relieved by methadone."3.71Successful use of oral methadone after failure of intravenous morphine and ketamine. ( Mitchell, SJ; Sartain, JB, 2002)
"The present study examined the effects of local peripheral and systemic administration of three clinically used excitatory amino acid receptor antagonists (dextromethorphan, memantine, ketamine) on pain behaviors and edema produced by formalin (1."3.71Modulation of formalin-induced behaviors and edema by local and systemic administration of dextromethorphan, memantine and ketamine. ( Reid, A; Sawynok, J, 2002)
"Three patients with localized superficial pain had their pain alleviated by single epidural infusion with low dose ketamine."3.71[Usefulness of epidural infusion of ketamine for relief of localized superficial pain]. ( Ikeda, M; Kamakura, T; Machida, K; Mizuno, J; Sugimoto, S, 2001)
"Our report describes for the first time the continuous long-term intrathecal application of S(+)-ketamine in a patient with chronic pain and morphine tolerance."3.71The long-term antinociceptive effect of intrathecal S(+)-ketamine in a patient with established morphine tolerance. ( Deusch, E; Kress, HG; Maier, P; Sator-Katzenschlager, S; Spacek, A, 2001)
"In this study, we compared pain reduction produced by IV drugs (ketamine or alfentanil) with the ability to prevent injury-induced spinal cord changes."3.70Pre- versus postformalin effects of ketamine or large-dose alfentanil in the rat: discordance between pain behavior and spinal Fos-like immunoreactivity. ( Coderre, TJ; Gilron, I; Quirion, R, 1999)
"To evaluate accident and emergency (A&E) department led practice of ketamine sedation for painful, short procedures in the paediatric population and to ascertain parental response."3.70Accident and emergency department led implementation of ketamine sedation in paediatric practice and parental response. ( Gautam, V; Holloway, VJ; Husain, HM; Saetta, JP, 2000)
"We evaluated the safety and efficacy of midazolam-ketamine association to control pain induced by diagnostic procedures in paediatric oncology patients."3.70Use of intravenous ketamine-midazolam association for pain procedures in children with cancer. A prospective study. ( Granry, JC; Le Moine, P; Monrigal, JP; Pellier, I; Rialland, X; Rod, B, 1999)
"The aim of the present study was to observe the effect of repeated subcutaneous (sc) injections of low doses of ketamine for the treatment of acute inflammatory pain in a complete Freund's adjuvant-induced monoarthritic pain model in rats."3.70Repeated administration of low dose ketamine for the treatment of monoarthritic pain in the rat. ( Cao, Y; Han, JS; Huang, C; Wang, Y, 2000)
" This was reached in 74 cases with only one dose of ketamine, in 26 cases a second dose was needed, a same number needed nitrous oxide in addition and 9 times a second dose and nitrous oxide was given."3.69[Analgetic ketamine feasible in ambulance emergency care]. ( Ansem, RP; Foudraine, JF; Hartman, JA; Rutten, FL; van Loenen, E, 1994)
"To assess the benefit of ketamine addition to a morphine-clonidine-lidocaine mixture administered continuously by the intrathecal route for the treatment of cancer pain."3.69[Cancer pain: beneficial effect of ketamine addition to spinal administration of morphine-clonidine-lidocaine mixture]. ( Lemos, D; Muller, A, 1996)
"Ketamine has been used parenterally for pain unresponsive to opioids, including neuropathic pain, and has also been used as an alternative analgesic agent after surgery."3.69Ketamine injection used orally. ( Broadley, KE; Kurowska, A; Tookman, A, 1996)
"We report the effect of a single daily dose of ketamine in a 54 year old woman with fibromyalgia and severe post-traumatic neuropathic pain."3.69[Analgesic effect of ketamine in a patient with neuropathic pain]. ( Fagerlund, TH; Oye, I; Rabben, T, 1996)
"The therapeutic effects of dextrorphan and ketamine, two non-competitive N-methyl-D-aspartate (NMDA) receptor antagonists, on neuropathic pain-related behaviors were examined in rats with peripheral mononeuropathy induced by loose ligation of the common sciatic nerve (chronic constrictive injury, CCI)."3.68Intrathecal treatment with dextrorphan or ketamine potently reduces pain-related behaviors in a rat model of peripheral mononeuropathy. ( Frenk, H; Hayes, RL; Lu, J; Mao, J; Mayer, DJ; Price, DD, 1993)
"Our experience has shown ketamine to be a safe and effective method of providing pain relief during specific procedures in burned children."3.68Ketamine. A solution to procedural pain in burned children. ( Groeneveld, A; Inkson, T, 1992)
"Both chiral forms of ketamine caused analgesia when administered in subanesthetic doses to human volunteers suffering acute, experimentally induced ischemic pain."3.68Evidence of a role for NMDA receptors in pain perception. ( Klepstad, P; Maurset, A; Moberg, ER; Oye, I, 1990)
"The effect of ketamine infusion to control the intractable pain which had not responded to ordinary procedures in 12 patients with advanced cancer were evaluated."3.68[Ketamine infusion for control of pain in patients with advanced cancer]. ( Kanamaru, T; Katsumata, N; Mizuno, K; Ogawa, S; Saeki, S; Suzuki, H, 1990)
"Continuous intravenous infusions of ketamine and pentazocine have been used to provide analgesia in 18 patients with acute war injuries."3.67Infusion analgesia for acute war injuries. A comparison of pentazocine and ketamine. ( Bion, JF, 1984)
" doses of the full benzodiazepine inverse agonist beta-CCE immediately following cessation of exposure of rats to an anesthetic concentration of methoxyflurane significantly antagonized the duration of methoxyflurane anesthesia as measured by recovery of the righting reflex and/or pain sensitivity."3.67Antagonism of methoxyflurane-induced anesthesia in rats by benzodiazepine inverse agonists. ( Miller, DW; Tessel, RE; Yourick, DL, 1989)
"Hemorrhage is a leading cause of preventable battlefield and civilian trauma deaths."3.30Comparing the Effects of Low-Dose Ketamine, Fentanyl, and Morphine on Hemorrhagic Tolerance and Analgesia in Humans. ( Belval, LN; Cramer, MN; Crandall, CG; Foster, J; Hendrix, JM; Hinojosa-Laborde, C; Huang, M; Moralez, G; Watso, JC, 2023)
"Ketamine is an inexpensive drug with mechanisms of analgesia outside the opioid pathway including N-methyl-D-aspartate (NMDA) receptor antagonism and a pharmacologically unique property of opioid desensitisation."3.30Efficacy of ketamine mouthwash in the management of oral and pharyngeal toxicity associated with head and neck chemoradiotherapy: protocol for a phase II, Simon's two-stage trial. ( Eckstein, J; Frank, D; Ghaly, M; Herman, J; Koffler, D; Kohn, N; Martins-Welch, D; Parashar, B; Potters, L; Seetharamu, N; Sullivan, K, 2023)
" The efficacy and safety of the sedations including sedation time intervals, nausea score, vomiting episodes, pain score, adverse effects, and parent's satisfaction were evaluated."3.11The efficacy and safety of midazolam with fentanyl versus midazolam with ketamine for bedside invasive procedural sedation in pediatric oncology patients: A randomized, double-blinded, crossover trial. ( Lertvivatpong, N; Malaithong, W; Monsereenusorn, C; Photia, A; Rujkijyanont, P; Traivaree, C, 2022)
"The combination of ketamine-dexmedetomidine for procedural sedation during ERCP is a safe alternative to ketamine-propofol with a better respiratory profile."3.11Ketamine and dexmedetomidine (Keto-dex) or ketamine and propofol (Keto-fol) for procedural sedation during endoscopic retrograde cholangiopancreatography: Which is safer? A randomized clinical trial. ( Ahuja, V; Aravindan, A; Datta, PK; Ganesh, V; Iyer, KV; Khanna, P; Maitra, S; Sarkar, S; Singh, A, 2022)
"Ketamine has analgesic and antidepressant effects, but few studies have evaluated individual differences in antidepressant outcomes to repeated ketamine in TRD patients with comorbid pain."3.01Plasma inflammatory cytokines and treatment-resistant depression with comorbid pain: improvement by ketamine. ( Chao, Z; Lan, X; Li, H; Ning, Y; Wang, C; Zhou, Y, 2021)
"Using Department of Defense Trauma Registry data for the Afghanistan conflict from 2005 to 2018, we examined 2,402 records of prehospital analgesia administration to assess temporal trends in medication choice and proportions receiving analgesia, including subanalysis of a cohort screened for an indication with minimal contraindication for analgesia."3.01Patterns of Palliation: A Review of Casualties That Received Pain Management Before Reaching Role 2 in Afghanistan. ( Burgess, M; Hinojosa-Laborde, C; Hudson, IL; Newberry, RK; Ryan, KL; Schauer, SG; Staudt, AM; VanFosson, CA, 2023)
"Agitation commonly complicates polytrauma presentations, and is treated according to the danger it presents to patient and staff."3.01Management of Pain and Agitation in Trauma. ( Strayer, RJ, 2023)
" Secondary outcomes included postoperative visual analog scale (VAS) scores for pain and adverse effects associated with ketamine."3.01Efficacy and safety of perioperative application of ketamine on postoperative depression: A meta-analysis of randomized controlled studies. ( Gu, HW; Guo, J; Hashimoto, K; Qiu, D; Wang, XM; Yang, JJ; Zhang, GF, 2023)
"Propofol is a commonly used sedative, frequently combined with an opioid or low-dose ketamine as an analgesic."3.01Low-dose ketamine or opioids combined with propofol for procedural sedation in the emergency department: a systematic review. ( De Vries, LJ; Lameijer, H; Van Roon, EN; Veeger, NJGM, 2023)
"Ketamine has received considerable attention for its rapid and robust antidepressant response over the past decade."3.01Oral ketamine may offer a solution to the ketamine conundrum. ( Can, AT; Dutton, M; Hermens, DF; Lagopoulos, J, 2023)
" Our primary outcome was the proportion of patients experiencing any psychoperceptual side effect over 60 minutes."2.87Slow Infusion of Low-dose Ketamine Reduces Bothersome Side Effects Compared to Intravenous Push: A Double-blind, Double-dummy, Randomized Controlled Trial. ( Clattenburg, EJ; Flores, S; Hailozian, C; Haro, D; Herring, AA; Louie, D; Yoo, T, 2018)
"Postpartum depression is a common complication of childbirth."2.84Single bolus low-dose of ketamine does not prevent postpartum depression: a randomized, double-blind, placebo-controlled, prospective clinical trial. ( Chen, D; Huang, X; Li, Y; Ma, D; She, B; Xu, Y, 2017)
"Management of refractory pain in pediatric sickle cell disease (SCD) and oncology is reliant on opioids though high opioid dosing increases side effects and tachyphylaxis."2.82Low-dose Ketamine Infusion for Pediatric Hematology/Oncology Patients: Case Series and Literature Review. ( Agrawal, AK; Chen, A; Chen, E; Long, LS; Yu, H, 2022)
"Treatment with ketamine also documented a reduction in the values of the VAS/NRS for pain (random effects WMD: -8."2.82Pharmacological treatment in adult patients with CRPS-I: a systematic review and meta-analysis of randomized controlled trials. ( Adami, G; Benini, C; Fassio, A; Gatti, D; Gavioli, I; Mantovani, A; Rossini, M; Viapiana, O, 2022)
" Recommended changes to dosing strategies of medications such as ketamine."2.82Analgesia and Sedation for Tactical Combat Casualty Care: TCCC Proposed Change 21-02. ( April, MD; Blackman, V; Brown, J; Butler, FK; Cunningham, CW; DesRosiers, TT; Drew, B; Fisher, AD; Gurney, JM; Holcomb, JB; Montgomery, HR; Morgan, MM; Motov, SM; Papalski, W; Remley, MA; Schauer, SG; Shackelford, SA; Sprunger, T, 2022)
"IN ketamine was administered at enrolment, with a supplementary dose after 15 min, if required."2.78Sub-dissociative dose intranasal ketamine for limb injury pain in children in the emergency department: a pilot study. ( Graudins, A; Meek, R; Oakley, E; Yeaman, F, 2013)
"Propofol is a widely used anesthetic drug because of its minor complication and also its fast effect."2.77Comparison of effects of ephedrine, lidocaine and ketamine with placebo on injection pain, hypotension and bradycardia due to propofol injection: a randomized placebo controlled clinical trial. ( Ayatollahi, V; Behdad, S; Kargar, S; Yavari, T, 2012)
"Ketamine is a dissociative anesthetic agent with excellent analgesic properties and a favorable safety profile."2.72A review of the clinical applications of ketamine in pediatric oncology. ( Gupta, AK; Meena, JP; Prakash, S; Seth, R, 2021)
"Cold allodynia and hyperalgesia are frequent clinical findings in patients with neuropathic pain."2.71Cold allodynia and hyperalgesia in neuropathic pain: the effect of N-methyl-D-aspartate (NMDA) receptor antagonist ketamine--a double-blind, cross-over comparison with alfentanil and placebo. ( Jørum, E; Stubhaug, A; Warncke, T, 2003)
"Hyperalgesia has been documented during withdrawal and on occasion while animals were still exposed to opioids."2.71Short-term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal. ( Angst, MS; Clark, DJ; Koppert, W; Pahl, I; Schmelz, M, 2003)
" Intranasal ketamine was well tolerated with no serious adverse events."2.71Safety and efficacy of intranasal ketamine for the treatment of breakthrough pain in patients with chronic pain: a randomized, double-blind, placebo-controlled, crossover study. ( Albin, R; Brennen, L; Brookoff, D; Carr, DB; Denman, WT; Firestone, L; Goudas, LC; Green, G; Hamilton, D; Lavin, PT; Mermelstein, F; Rogers, MC; Staats, PS, 2004)
"The area of secondary hyperalgesia was quantitated using punctate (von Frey filaments) and brush stimuli (electric brush)."2.69Preinjury treatment with morphine or ketamine inhibits the development of experimentally induced secondary hyperalgesia in man. ( Jørum, E; Stubhaug, A; Warncke, T, 2000)
"Ketamine is a noncompetitive N-methyl-D-aspartate (NMDA) receptor channel blocker known to inhibit "wind-up" and hence central hyperexcitability of dorsal horn neurons."2.68The effect of N-methyl-D-aspartate antagonist (ketamine) on single and repeated nociceptive stimuli: a placebo-controlled experimental human study. ( Arendt-Nielsen, L; Bak, P; Bjerring, P; Fischer, M; Petersen-Felix, S; Zbinden, AM, 1995)
"Pain was evoked by non-noxious stimulation of the skin (allodynia) and by repeated pricking of the skin (wind-up-like pain)."2.68Central dysesthesia pain after traumatic spinal cord injury is dependent on N-methyl-D-aspartate receptor activation. ( Eide, PK; Stenehjem, AE; Stubhaug, A, 1995)
"The reduction in allodynia evoked by light stroking was statistically significant only for alfentanil."2.68Effects of intravenous ketamine, alfentanil, or placebo on pain, pinprick hyperalgesia, and allodynia produced by intradermal capsaicin in human subjects. ( Bennett, GJ; Gracely, RH; Max, MB; Park, KM; Robinovitz, E, 1995)
"Pain was assessed using visual analogue scales and sedation was graded on a four point rank drowsiness score."2.68Analgesia for acute musculoskeletal trauma: low-dose subcutaneous infusion of ketamine. ( Bhattacharya, A; Gurnani, A; Rautela, RS; Sharma, PK, 1996)
"Pain was analyzed in patients with fibromyalgia (FM) in a randomized, double blind, crossover study using intravenous (i."2.68Fibromyalgia--are there different mechanisms in the processing of pain? A double blind crossover comparison of analgesic drugs. ( Ahlner, J; Bengtsson, A; Bengtsson, M; Ekselius, L; Henriksson, KG; Sörensen, J, 1997)
"Ischemic pain was induced by the submaximum effort tourniquet technique."2.67The influence of adenosine, ketamine, and morphine on experimentally induced ischemic pain in healthy volunteers. ( Ekblom, A; Segerdahl, M; Sollevi, A, 1994)
"Ketamine is an NMDA-blocking agent widely used in human medicine."2.67Response of chronic neuropathic pain syndromes to ketamine: a preliminary study. ( Arndt, G; Backonja, M; Check, B; Gombar, KA; Zimmermann, M, 1994)
"Twenty traumatized patients suffering from fractures and soft tissue injury were given either 0."2.66[Intravenous analgesia with ketamine for emergency patients]. ( Hirlinger, WK; Pfenninger, E, 1987)
"Ketamine has unique pharmacologic properties that may prevent the development of pain as well as reduce chronic pain."2.58Emerging Trends in Pain Medication Management: Back to the Future: A Focus on Ketamine. ( Atkinson, TJ; Bryant, C; Crumb, MW, 2018)
" A literature review was performed to ascertain potential side effects and/or adverse events when using ketamine for analgesia purposes."2.55Ketamine for Pain Management-Side Effects & Potential Adverse Events. ( Allen, CA; Ivester, JR, 2017)
"Mechanistic approaches and multimodal analgesic techniques have been clearly demonstrated to be the most effective pain management strategy to improve outcomes."2.55Analgesia in the surgical intensive care unit. ( Brudney, CS; Ehieli, E; Pyati, S; Yalamuri, S, 2017)
"Ketamine is a fast acting N-methyl-d-aspartate (NMDA) receptor antagonist that provides safe and effective analgesia."2.55Low dose ketamine use in the emergency department, a new direction in pain management. ( Alhawas, R; Mazer-Amirshahi, M; Pourmand, A; Royall, C; Shesser, R, 2017)
"Ketamine is a phencyclidine derivative, which functions primarily as an antagonist of the N-methyl-D-aspartate receptor."2.53Ketamine: A Review of Clinical Pharmacokinetics and Pharmacodynamics in Anesthesia and Pain Therapy. ( Hagelberg, NM; Olkkola, KT; Peltoniemi, MA; Saari, TI, 2016)
" Apart from being valuable in drug development programs, the outlined approach can be used to determine the choice of drug and dose in the treatment of pain in patients with potent and toxic analgesics."2.52Pharmacotherapy for pain: efficacy and safety issues examined by subgroup analyses. ( Dahan, A; Niesters, M; Olofsen, E, 2015)
"Propofol is an agent commonly used for procedural sedation and analgesia (PSA) in the emergency department (ED), but it can cause respiratory depression and hypotension."2.52Ketamine-Propofol Versus Propofol Alone for Procedural Sedation in the Emergency Department: A Systematic Review and Meta-analysis. ( Iansavitchene, A; McLeod, SL; Yan, JW, 2015)
" After long-term use as a dissociative anesthetic, it has re-emerged as a useful agent for ameliorating pain, asthmaticus, and depression."2.50Ketamine-an update on its clinical uses and abuses. ( Lei, H; Xu, J, 2014)
"Intubation of the trachea and mechanical ventilation are ubiquitous painful procedures in the neonatal intensive care unit that are poorly assessed and treated."2.49Sedation and analgesia to facilitate mechanical ventilation. ( Colby, CE; Nemergut, ME; Yaster, M, 2013)
"Studies on oral ketamine for cancer and neuropathic pain have shown mixed results which could be partially due to significant differences in hepatic metabolism."2.48Oral ketamine in the palliative care setting: a review of the literature and case report of a patient with neurofibromatosis type 1 and glomus tumor-associated complex regional pain syndrome. ( Baker, K; Berger, AM; Handel, D; Mannes, AJ; Ruppert, SL; Soto, E; Stewart, DR; Zlott, D, 2012)
"Ketamine is a lipophilic, general anesthetic."2.48Ketamine for pain: an update of uses in palliative care. ( Prommer, EE, 2012)
" It also reviews the comparative pharmacokinetics, adverse effects, and dosing of ketamine, propofol, and ketofol as agents for procedural sedation and analgesia."2.48Ketamine, propofol, and ketofol use for pediatric sedation. ( Alletag, MJ; Auerbach, MA; Baum, CR, 2012)
"In spite of improvements in wound treatment and pain regimens during recent years, the management of burn pain still remains a common problem and a tremendous challenge for clinical staff."2.47[Pain management of burn injuries]. ( Girtler, R; Gustorff, B, 2011)
"Ketamine has become increasingly recognized as a drug of recreational use."2.47Recreational ketamine: from pleasure to pain. ( Baker, SC; Cottrell, A; Fulford, S; Gillatt, D; Harris, M; Southgate, J; Wood, D; Woodhouse, C, 2011)
"Ketamine is an N-methyl-D-aspartate receptor antagonist that has been in clinical use in the USA for over 30 years."2.47Ketamine in pain management. ( Cohen, SP; Gupta, A; Liao, W; Plunkett, A, 2011)
"Ketamine is a safe and effective analgesic agent."2.47Ketamine as an analgesic in the pre-hospital setting: a systematic review. ( Bernard, S; Cameron, P; Jennings, PA, 2011)
" There was no consistent dose-response relation."2.46Use of oral ketamine in chronic pain management: a review. ( Blonk, MI; Huygen, FJ; Koder, BG; van den Bemt, PM, 2010)
"Ketamine has been shown to produce antihyperalgesic effects produced by incision and tissue or nerve damage, and has become popular in equine practice as an anesthetic and more recently as an analgesic for standing surgical procedures and the treatment of laminitis."2.46NMDA receptor antagonists and pain: ketamine. ( Muir, WW, 2010)
"neuropathic pain) is not very satisfactorily managed."2.44[Central and peripheral mechanisms in antinociception: current and future perspectives]. ( Fürst, Z, 2008)
"Ketamine is a dissociative anaesthetic that has been used in the clinic for many years."2.44Low dose ketamine: a therapeutic and research tool to explore N-methyl-D-aspartate (NMDA) receptor-mediated plasticity in pain pathways. ( Chizh, BA, 2007)
"Pain is an unpleasant sensation that originates from ongoing or impending tissue damage."2.44Recent advances in the pharmacological management of pain. ( Beaulieu, P; Guindon, J; Walczak, JS, 2007)
"Pain is a multidimensional symptom that can overshadow all other experiences of both the child and family."2.44The management of pain in children with life-limiting illnesses. ( Friedrichsdorf, SJ; Kang, TI, 2007)
" Nursing considerations include close monitoring of vital signs during the initial dosage and follow-up observations of the effectiveness of the medications."2.44The use of ketamine as adjuvant therapy to control severe pain. ( Campbell-Fleming, JM; Williams, A, 2008)
"Ketamine is a dissociative anaesthetic; its mechanism of action is primarily an antagonism of the N-methyl-D-aspartate (NMDA) receptor."2.43The role of ketamine in pain management. ( Schug, SA; Visser, E, 2006)
"Intense pain and cutaneous hyperesthesia are prominent features."2.43Symptomatic management of calciphylaxis: a case series and review of the literature. ( Ashby, MA; Bryan, T; Martin, P; Polizzotto, MN, 2006)
"Dextromethorphan and ketamine were found to have significant immediate and preventive analgesic benefit in 67% and 58% of studies, respectively."2.42A qualitative systematic review of the role of N-methyl-D-aspartate receptor antagonists in preventive analgesia. ( Katz, J; McCartney, CJ; Sinha, A, 2004)
"Pain is the primary problem targeted for control using the World Health Organization's (WHO) analgesic ladder."2.41Advances in cancer pain management. ( Hamann, SR; McDonnell, FJ; Sloan, JW, 2000)
"Tramadol is a centrally acting analgesic drug; it has an agonist effect on mu 1 receptors of opioids and acts also by inhibiting the re-uptake of noradrenaline and serotonine which activates descending monoaminergic inhibitory pathways."2.40[Treatment of pain in oncology]. ( De Conno, F; Polastri, D, 1997)
"Pain is an important indicator of stress particularly after surgical operation."2.39Clinical applications of excitatory amino acid antagonists in pain management. ( Cherng, CH; Ho, ST; Wong, CS, 1995)
"Ketamine has been shown to have potent analgesic properties at low dosages."2.39Ketamine in cancer pain: an update. ( Mercadante, S, 1996)
" Demographic and clinical data, including age, length of the procedure, recovery time, medication doses, and adverse events, were collected."1.91Safety and Efficacy of Propofol- and Ketamine-Based Procedural Sedation Regimen in Pediatric Patients During Burn Repetitive Dressing Change: 10 Years Single Center Experience. ( Abu-Sultaneh, S; Abulebda, K; Lutfi, R; Shieh Yu, J; Slaven, JE; Yabrodi, M, 2023)
" This study aimed to evaluate differences in pain management and adverse effects of ketamine and opioid administration."1.91Treating Prehospital Pain in Children: A Retrospective Chart Review Comparing the Safety and Efficacy of Prehospital Pediatric Ketamine and Opioid Analgesia. ( Brent, C; Cranford, JA; Hunt, N; Mahmood, A; Masiewicz, S; Noel, S; Wagner, D, 2023)
"Ketamine was started a median of 13."1.91Ketamine use for management of vaso-occlusive pain in pediatric sickle cell disease. ( Archer, NM; Donado, C; Greco, C; Harris, EM; Heeney, MM; Solodiuk, J; Vilk, E; Williams, A, 2023)
"Ketamine has been used in the emergency department (ED) as an anesthetic agent for procedural sedation, and when administrated in a sub-dissociative dose (low dose) at 0."1.72Paraphimosis Pain Treatment with Nebulized Ketamine in the Emergency Department. ( Barberan Parraga, C; Cen, E; Davis, A; Dove, D; Drapkin, J; Fassassi, C; Hossain, R; Mahl, E; Motov, S; Peng, Y, 2022)
"Erythromelalgia is a rare neurovascular pain condition characterized by erythematous, warm, and painful extremities."1.72Intravenous Ketamine Infusion as an Adjunctive Pain Treatment for Erythromelalgia: A Pediatric Case Report. ( Adams, AC; Montoya, L; Popenhagen, MP; Price, HN; Russi, DC; Singhal, NR, 2022)
"Ketamine was identified as safe and effective for battlefield use, and further research into nonopioid analgesics represented a high priority."1.72Battlefield pain summit 2022: Expert consensus statements. ( Cannon, JW; Cap, AP; Davidson, NL; Polk, TM; Shackelford, SA; Stallings, JD; Stark, TR, 2022)
"Ketamine was administered to mice acute and chronically with/without nitric oxide synthase (NOS) inhibitors."1.72The N-methyl-D-aspartate receptor antagonist ketamin exerts analgesic effects via modulation of the nitric oxide pathway. ( Dehpour, AR; Goudarzi, S; Mahmoudzade, S; Mohammad Jafari, R; Sanatkar, M; Shafaroodi, H, 2022)
"Pediatric lacerations are frequently encountered by plastic surgeons in the emergency room."1.72Effect of sedation using Ketamine for primary closure of pediatric facial laceration. ( Kim, HJ; Kim, JH; Kim, SH; Lee, JH; Shin, SH; Suh, IS; Woo, SS, 2022)
" Kinetic analyses of MLK infusions in cattle are necessary to establish optimal dosing protocols and withdrawal intervals."1.56Analgesic efficacy of an intravenous constant rate infusion of a morphine-lidocaine-ketamine combination in Holstein calves undergoing umbilical herniorrhaphy. ( Coetzee, JF; Hartnack, AK; Kleinhenz, MD; Lakritz, J; Niehaus, AJ, 2020)
"Drugs used to treat pain are associated with adverse effects, increasing the search for new drugs as an alternative treatment for pain."1.56Antinociceptive activity of 3β-6β-16β-trihydroxylup-20 (29)-ene triterpene isolated from Combretum leprosum leaves in adult zebrafish (Danio rerio). ( Bandeira, PN; Campos, AR; da Silva, AW; de Menezes, JESA; Dos Reis Lima, J; Dos Santos, HS; Evaristo, FFV; Ferreira, MKA; Holanda, CLA; Magalhães, FEA; Silva, FCO; Teixeira, EH, 2020)
"Ketamine infusions have been reported to help alleviate acute exacerbations or "flare-ups" of CRPS symptoms."1.56Anesthetic Management of a Complex Regional Pain Syndrome (CRPS) Patient With Ketamine. ( Mundluru, T; Saraghi, M, 2020)
"capsaicin-induced thermal allodynia) are unknown."1.48Additive and subadditive antiallodynic interactions between μ-opioid agonists and N-methyl D-aspartate antagonists in male rhesus monkeys. ( Banks, ML; Cornelissen, JC; Nicholson, KL; Rice, KC; Steele, FF, 2018)
"Ketamine has been widely used as an analgesic and produces dissociative anesthetic effects."1.48The Involvement of the Endocannabinoid System in the Peripheral Antinociceptive Action of Ketamine. ( Castor, MGM; Di Marzo, V; Duarte, IDG; Ferreira, RCM; Piscitelli, F; Romero, TRL, 2018)
"Ketamine is an effective drug for battlefield analgesia."1.48Ketamine for military prehospital analgesia and sedation in combat casualties. ( Moy, R; Wright, C, 2018)
" Outcomes studied included impact on opioid analgesic use, a description of ketamine dosing strategy, and an analysis of adverse events due to opioid or ketamine analgesia."1.48Low-Dose Ketamine Infusion for Adjunct Management during Vaso-occlusive Episodes in Adults with Sickle Cell Disease: A Case Series. ( Boylan, A; Floroff, C; Hassig, TB; Kanter, J; Palm, N, 2018)
"The administration of ketamine during burn wound care using a critical care RN-driven protocol was associated with reduced opioid and benzodiazepine requirements and few adverse effects."1.48CE: Original Research: The Efficacy and Safety of an RN-Driven Ketamine Protocol for Adjunctive Analgesia During Burn Wound Care. ( Baumgartner, L; MacLaren, R; Townsend, N; Winkelman, K, 2018)
"Patients with advanced cancer often suffer from both severe pain and severe symptoms of depression."1.48Case Report: Ketamine for Pain and Depression in Advanced Cancer. ( Atayee, RS; Bruner, HC; Sexton, J, 2018)
"Current therapeutic approaches to depression fail for millions of patients due to lag in clinical response and non-adherence."1.46Population scale data reveals the antidepressant effects of ketamine and other therapeutics approved for non-psychiatric indications. ( Abagyan, R; Atayee, R; Cohen, IV; Makunts, T, 2017)
" This adverse effect has not been reported previously at this dosing range."1.46A Case Report: Subanesthetic Ketamine Infusion for Treatment of Cancer-Related Pain Produces Urinary Urge Incontinence. ( Hunsberger, J; Lee, W; Vickers, BA, 2017)
"Meperidine was applied to animals with increasing doses and their tail flick latencies (TFL) were noted at 20, 40, 60, 90, 120, 180, and 240 min."1.43Combination of paracetamol or ketamine with meperidine enhances antinociception. ( Akkar, OB; Cetin, A; Cetin, M; Gulturk, S; Kula, A, 2016)
" In the acute toxicity test, the LD50 estimated for CPE was>5000 mg/kg p."1.43Pharmacological effects and toxicity of Costus pulverulentus C. Presl (Costaceae). ( Alonso-Castro, AJ; Carranza-Álvarez, C; González-Chávez, MM; Hernández-Benavides, DM; Hernández-Morales, A; Zapata-Morales, JR, 2016)
"Fentanyl was preferred for paediatric patients and ketamine was preferentially administered for severe pain by physicians who had more medical experience or had trained in anaesthesia."1.43A two-year retrospective review of the determinants of pre-hospital analgesia administration by alpine helicopter emergency medical physicians to patients with isolated limb injury. ( Albrecht, E; Eidenbenz, D; Hugli, O; Pasquier, M; Taffé, P, 2016)
"Pain is a significant side effect of disease, surgery and treatments including chemotherapy."1.43Pain management for chemotherapy-induced oral mucositis. ( Bennett, M, 2016)
"Intractable cancer-related pain complicated by a neuropathic component due to nerve impingement is poorly alleviated even by escalating doses of a strong opioid analgesic."1.42Novel polymeric bioerodable microparticles for prolonged-release intrathecal delivery of analgesic agents for relief of intractable cancer-related pain. ( Han, FY; Lam, AL; Smith, MT; Thurecht, KJ; Whittaker, AK, 2015)
"IN ketamine dose was 0."1.40Sub-dissociative-dose intranasal ketamine for moderate to severe pain in adult emergency department patients. ( Egerton-Warburton, D; Graudins, A; Meek, R; Rosengarten, P; Yeaman, F, 2014)
"Ketamine was administered into the right hind paw 2 hours and 55 minutes after local injection of PGE2 ."1.39Involvement of ATP-sensitive K(+) channels in the peripheral antinociceptive effect induced by ketamine. ( Duarte, ID; Romero, TR, 2013)
"Pain is a problem that often has to be addressed in the prehospital setting."1.39Prehospital analgesia using nasal administration of S-ketamine--a case series. ( Johansson, J; Nordgren, M; Sandström, E; Sjöberg, F; Sjöberg, J; Zetterström, H, 2013)
"The ketamine usage pattern was recorded: initiation, administration route, dose in the last month and frequency of usage."1.38[Cystitis and ketamine associated bladder dysfunction]. ( Arango, O; Bielsa, O; Castillo, C; García-Larrosa, A; Lorente, JA; Ventura, M, 2012)
"Ketamine was administered epidurally at doses of 1 and 2 mg kg(-1) (five animals in each treatment)."1.38Epidural ketamine in the dromedary camel. ( Azari, O; Emadi, L; Esmaeili, M; Molaei, MM; Sakhaee, E, 2012)
"Pain was also improved, although for a shorter duration."1.38Mood and pain responses to repeat dose intramuscular ketamine in a depressed patient with advanced cancer. ( Glue, P; Perez, D; Zanicotti, CG, 2012)
"heat allodynia) followed by a persistent area of secondary tactile allodynia."1.36Human experimental pain models 3: heat/capsaicin sensitization and intradermal capsaicin models. ( Modir, JG; Wallace, MS, 2010)
" With intravenous administration the onset of action is within 1 min and the effects last for about 5 to 10 min, depending on dosage level and individual variation."1.36Taming the ketamine tiger. 1965. ( Domino, EF, 2010)
"It had less effect on tactile allodynia (CCI)."1.35Effects of norketamine enantiomers in rodent models of persistent pain. ( Crooks, PA; Hojomat, M; Holtman, JR; Johnson-Hardy, JK; Kleven, M; Wala, EP, 2008)
"Oral ketamine has been found to be effective during invasive procedures in children with malignancy."1.35Oral ketamine for pain relief in a child with abdominal malignancy. ( Boyaci, A; Gulcu, N; Ugur, F, 2009)
"Premature infants experience untreated repetitive pain that may alter their brain development."1.34Ketamine reduces the cell death following inflammatory pain in newborn rat brain. ( Anand, KJ; Bhutta, AT; Garg, S; Hall, RW; Narsinghani, U; Rovnaghi, CR, 2007)
"Ketamine is an ideal drug for use in many prehospital situations."1.34Ketamine for prehospital use: new look at an old drug. ( Abernathy, MK; Svenson, JE, 2007)
"Pretreatment with resiniferatoxin, an ultrapotent analogue of capsaicin, halved during-discharges and eliminated after-discharges, suggesting that after-discharges are generated by heat- and mechanosensitive polymodal nociceptors."1.33Spinal ventral root after-discharges as a pain index: involvement of NK-1 and NMDA receptors. ( Honda, M; Ono, H; Tanabe, M; Yamamoto, S, 2006)
"Opiates may be used to attenuate chronic pain, but long-term use is complicated by the possible increase in pain over time, escalating dose requirements, and untoward side effects."1.33Enhancement of morphine antinociception with the peptide N-methyl-D-aspartate receptor antagonist [Ser1]-histogranin in the rat formalin test. ( Basler, A; Hama, A; Sagen, J, 2006)
"Muscle pain is a major clinical problem but the underlying mechanisms and its pharmacological modulation need further investigation."1.32Pharmacological modulation of experimental phasic and tonic muscle pain by morphine, alfentanil and ketamine in healthy volunteers. ( Arendt-Nielsen, L; Graven-Nielsen, T; Jansson, Y; Schulte, H; Segerdahl, M; Sollevi, A, 2003)
"When ketamine was used as the general anesthetic, self-mutilation was almost suppressed (13%) and consisted of superficial erosions."1.32Effects of anesthesia and nociceptive stimulation in an experimental model of brachial plexus avulsion. ( Rokyta, R; Vaculín, S, 2004)
"Dextromethorphan produced lower ED(50) values for morphine, fentanyl and sufentanil but exerted no effect on the potency of SNC80 or U50,488H."1.31Dextromethorphan and ketamine potentiate the antinociceptive effects of mu- but not delta- or kappa-opioid agonists in a mouse model of acute pain. ( Baker, AK; Hoffmann, VL; Meert, TF, 2002)
"The initial hyperalgesia induced by 0."1.31Large-amplitude 5-HT1A receptor activation: a new mechanism of profound, central analgesia. ( Assié, MB; Bardin, L; Carilla-Durand, E; Colpaert, FC; Cosi, C; Koek, W; Pauwels, PJ; Tarayre, JP; Vacher, B; Wiesenfeld-Hallin, Z; Xu, XJ, 2002)
"Clonidine was also evaluated in combination with ketamine and dextromethorphan."1.31Interactions of NMDA antagonists and an alpha 2 agonist with mu, delta and kappa opioids in an acute nociception assay. ( Baker, AK; Hoffmann, VL; Meert, TF, 2002)
"Neuropathic pain has been shown to respond to drugs that block the N-methyl-D-aspartate (NMDA) receptor, such as ketamine and amantidine."1.31An unusual case of chronic neuropathic pain responds to an optimum frequency of intravenous ketamine infusions. ( Mitchell, AC, 2001)
"Ketamine is a non-competitive N-methyl D-aspartate (NMDA) receptor antagonist with analgesic and dissociative anesthetic properties."1.31Low dose ketamine as an analgesic adjuvant in difficult pain syndromes: a strategy for conversion from parenteral to oral ketamine. ( Fitzgibbon, EJ; Hall, P; Schroder, C; Seely, J; Viola, R, 2002)
"Ketamine has been found to exert antinociceptive effects in animals and to be analgesic at subanaesthetic doses in humans."1.31Potentiation by ketamine of fentanyl antinociception. I. An experimental study in rats showing that ketamine administered by non-spinal routes targets spinal cord antinociceptive systems. ( Bajunaki, E; Goodchild, CS; Nadeson, R; Tucker, A, 2002)
"The onset of resultant hyperalgesia was evaluated using von Frey monofilaments."1.30Preemptive intrathecal ketamine delays mechanical hyperalgesia in the neuropathic rat. ( Hartrick, CT; Patterson, JS; Wise, JJ, 1998)
"His pain was diagnosed as neuropathic pain (complex regional pain syndrome, type II)."1.30The NMDA-receptor antagonist ketamine abolishes neuropathic pain after epidural administration in a clinical case. ( Miyazaki, M; Morita, S; Nanbu, T; Takahashi, H; Yanagida, H, 1998)
"Ketamine has been found to be a useful agent for analgesia in burn-wound patients; a dose of 10 mg/kg qid per os was found to be an effective adjunct to pain therapy."1.30Ketamine hydrochloride--an adjunct for analgesia in dogs with burn wounds. ( Joubert, K, 1998)
"The present study was designed to evaluate the oral efficacy and bioavailability of ketamine."1.30Oral ketamine is antinociceptive in the rat formalin test: role of the metabolite, norketamine. ( Elliott, KJ; Gorman, AL; Inturrisi, CE; Shimoyama, M; Shimoyama, N, 1999)
"Ketamine was not observed to produce any change in either RF size or neuronal response to non-noxious RF stimulation."1.29Effect of propofol on spinal dorsal horn neurons. Comparison with lack of ketamine effects. ( Collins, JG; Kishikawa, K; Uchida, H, 1995)
"(S)-Ketamine was at least 4 times as potent as (R)-ketamine in this respect."1.28Effects of ketamine on sensory perception: evidence for a role of N-methyl-D-aspartate receptors. ( Maurset, A; Oye, I; Paulsen, O, 1992)
"Ketamine was injected peritoneally in dosage of 4 mg/kg and 20 mg/kg respectively."1.28[Effect of ketamine on acupuncture analgesia]. ( Chen, ZQ; Xu, W; Yan, YS, 1989)
"Newer approaches to assessing and managing pain in these patients must be explored."1.27Pain control during the intensive care phase of burn care. ( Heimbach, DM; Marvin, JA, 1985)
"If emergency physicians would treat the pain of their patients as they would want it to be treated in themselves or their families, then we will have made great strides as a specialty in mastering the art and science of analgesia."1.27Pain management in the child. ( Paris, PM, 1987)
" Plasma ketamine concentration-time curves were fitted by a two-compartment open model with a terminal half-life of 186 min."1.26Bioavailability, pharmacokinetics, and analgesic activity of ketamine in humans. ( Clements, JA; Grant, IS; Nimmo, WS, 1982)
"Pain was produced by brief electric stimuli on the wrist."1.25Hypno-analgesia and acupuncture analgesia: a neurophysiological reality? ( Brown, M; Saletu, B; Saletu, M; Sletten, I; Stern, J; Ulett, G, 1975)

Research

Studies (598)

TimeframeStudies, this research(%)All Research%
pre-199024 (4.01)18.7374
1990's82 (13.71)18.2507
2000's199 (33.28)29.6817
2010's193 (32.27)24.3611
2020's100 (16.72)2.80

Authors

AuthorsStudies
Yu, H1
Chen, A1
Chen, E2
Long, LS1
Agrawal, AK2
Heydari, F1
Zhou, Y2
Wang, C2
Lan, X2
Li, H1
Chao, Z1
Ning, Y2
Madathil, S1
Thomas, D1
Chandra, P1
Agarwal, R1
Sankar, MJ1
Thukral, A1
Deorari, A1
Aminnejad, R1
Hormati, A1
Shafiee, H1
Alemi, F1
Hormati, M1
Saeidi, M1
Ahmadpour, S1
Sabouri, SM1
Aghaali, M1
Qiu, J1
Xie, M1
Aghaei, V1
Hino, C1
Ran-Castillo, D1
Akhtari, M1
Cao, H1
Silvestre, J1
Barberan Parraga, C1
Peng, Y1
Cen, E1
Dove, D1
Fassassi, C1
Davis, A1
Drapkin, J3
Hossain, R1
Mahl, E1
Motov, S3
Fassio, A1
Mantovani, A1
Gatti, D1
Rossini, M1
Viapiana, O1
Gavioli, I1
Benini, C1
Adami, G1
Singh, V1
Gillespie, TW1
Lane, O1
Spektor, B1
Zarrabi, AJ1
Egan, K1
Curseen, K1
Tsvetkova, M1
Beumer, JH1
Sniecinski, R1
Shteamer, JW1
Switchenko, J1
Harvey, RD1
Olofsen, E5
Kamp, J1
Henthorn, TK1
van Velzen, M1
Niesters, M9
Sarton, E6
Dahan, A11
van Bockxmeer, JJ1
Lau, A1
Varshney, V1
Mashour, GA1
Hayashi, M1
Shimamura, Y1
Shiroshita, A1
Cooper-Sood, JB1
Hagar, W1
Marsh, A1
Hoppe, C1
Montoya, L1
Adams, AC1
Popenhagen, MP1
Russi, DC1
Singhal, NR1
Price, HN1
Ballard, ED1
Farmer, CA1
Gerner, J1
Bloomfield-Clagett, B1
Park, LT1
Zarate, CA1
Li, X1
Xiang, P1
Liang, J1
Deng, Y1
Du, J1
Grégoire, C1
De Kock, M2
Henrie, J1
Cren, R1
Lavand'homme, P3
Penaloza, A1
Verschuren, F1
Cohen, B2
Talmy, T1
Gelikas, S1
Radomislensky, I1
Kontorovich-Chen, D1
Benov, A1
Avital, G1
Fisher, AD1
DesRosiers, TT1
Papalski, W1
Remley, MA1
Schauer, SG3
April, MD2
Blackman, V1
Brown, J1
Butler, FK1
Cunningham, CW1
Gurney, JM1
Holcomb, JB1
Montgomery, HR1
Morgan, MM1
Motov, SM2
Shackelford, SA2
Sprunger, T1
Drew, B1
Stark, TR1
Davidson, NL1
Cannon, JW1
Polk, TM1
Stallings, JD1
Cap, AP1
Jen, TTH1
Victor, AD1
Ke, JXC1
Asgardoon, MH1
Jazayeri, SB1
Behkar, A1
Dabbagh Ohadi, MA1
Yarmohammadi, H1
Ghodsi, Z1
Pomerani, TI1
Mojtahedzadeh, M1
Rahimi-Movaghar, V1
Mahmoudzade, S1
Goudarzi, S1
Mohammad Jafari, R1
Shafaroodi, H1
Dehpour, AR1
Sanatkar, M1
Patrick, C1
Smith, M1
Rafique, Z1
Rogers Keene, K1
De La Rosa, X1
Corwell, BN1
Davis, NL1
Kim, HK1
Chin, J1
McGrath, M1
Lokken, E1
Upegui, CD1
Prager, S1
Micks, E1
Fu, D1
Wang, D1
Li, W2
Han, Y1
Jia, J1
Lee, JH3
Woo, SS1
Shin, SH1
Kim, HJ1
Kim, JH1
Kim, SH3
Suh, IS1
Azarfar, A1
Ravanshad, Y1
Golsorkhi, M1
Zahiri, E1
Gharavi Fard, M1
Akhondi, M1
Ghodsi, A1
Ravanshad, S1
Li, CY1
Chen, ZY1
He, HF1
Wang, HG1
Xu, LM1
Efune, PN1
Rebstock, SE1
Hannon, CP1
Fillingham, YA1
Gililland, JM1
Sporer, SM1
Hamilton, WG1
Della Valle, CJ1
Ishida, Y1
Habu, MI1
Toba, Y1
Hudson, IL1
Staudt, AM1
Burgess, M1
Hinojosa-Laborde, C3
Newberry, RK1
Ryan, KL2
VanFosson, CA1
Yabrodi, M1
Shieh Yu, J1
Slaven, JE1
Lutfi, R1
Abulebda, K1
Abu-Sultaneh, S1
Monsereenusorn, C2
Malaithong, W1
Lertvivatpong, N1
Photia, A1
Rujkijyanont, P2
Traivaree, C2
Cohen, SP6
Khunsriraksakul, C1
Yoo, Y1
Parker, E1
Samen-Akinsiku, CDK1
Patel, N1
Cohen, SJ1
Yuan, X1
Cheng, J1
Moon, JY1
Tam, YS1
Poh, ZE1
Chia, G1
Provido, M1
Hum, A1
Lee, HX1
Strayer, RJ3
Chan, EOT3
Chan, VWS3
Tang, TST3
Cheung, V3
Wong, MCS3
Yee, CH3
Ng, CF3
Teoh, JYC3
Singh, A1
Iyer, KV1
Maitra, S1
Khanna, P1
Sarkar, S1
Ahuja, V1
Aravindan, A1
Datta, PK1
Ganesh, V1
Guo, J1
Qiu, D1
Gu, HW1
Wang, XM1
Hashimoto, K1
Zhang, GF1
Yang, JJ1
Watso, JC1
Huang, M1
Hendrix, JM1
Belval, LN1
Moralez, G1
Cramer, MN1
Foster, J1
Crandall, CG1
Eimer, C1
Reifferscheid, F1
Jung, P1
Rudolph, M1
Terboven, T1
Hoffmann, F1
Lorenzen, U1
Köser, A1
Seewald, S1
Mahmood, A1
Hunt, N1
Masiewicz, S1
Cranford, JA1
Noel, S1
Brent, C1
Wagner, D1
Mukherjee, K1
Schubl, SD1
Tominaga, G1
Cantrell, S1
Kim, B1
Haines, KL1
Kaups, KL1
Barraco, R1
Staudenmayer, K1
Knowlton, LM1
Shiroff, AM1
Bauman, ZM1
Brooks, SE1
Kaafarani, H1
Crandall, M1
Nirula, R1
Agarwal, SK1
Como, JJ1
Haut, ER1
Kasotakis, G1
Dubecq, C3
Montagnon, R2
Morand, G1
De Rocquigny, G2
Petit, L1
Peyrefitte, S1
Dubourg, O1
Pasquier, P2
Mahe, P1
Frawley, J1
Goyal, A1
Gappy, R1
Sandoval, S1
Chen, NW1
Crowe, R1
Swor, R1
Harris, EM3
Vilk, E2
Donado, C2
Williams, A2
Heeney, MM2
Solodiuk, J2
Greco, C2
Archer, NM3
Py, N1
Torres Soblechero, L1
Ocampo Benegas, DE1
Manrique Martín, G1
Butragueño Laiseca, L1
Leal Barceló, AM1
Parreño Marchante, A1
López-Herce Cid, J1
Mencía Bartolome, S1
Persad, E1
Pizarro, AB1
Bruschettini, M1
Koffler, D1
Eckstein, J1
Herman, J1
Martins-Welch, D1
Seetharamu, N1
Ghaly, M1
Kohn, N1
Potters, L1
Frank, D1
Sullivan, K1
Parashar, B1
Kearns, RJ1
Nelson, SM1
Ertem, FU1
Eubanks, J1
Saul, M1
Kang, CR1
Emerick, T1
Yadav, D1
Pribonic, AP1
Brancolini, SA1
Brea, F1
Cladis, FP1
Wu, Z1
Gan, Y1
Li, N1
Zhang, F1
Liu, H2
Ye, Y1
Hu, Z1
Vogt, KM2
Ibinson, JW2
Burlew, AC1
Smith, CT2
Aizenstein, HJ2
Fiez, JA2
De Vries, LJ1
Veeger, NJGM1
Van Roon, EN1
Lameijer, H1
Levinstein, MR1
Michaelides, M1
Chen, H1
Ding, X1
Xiang, G1
Xu, L3
Liu, Q2
Fu, Q1
Li, P1
Qureshi, AA1
Prescott, MG1
Iakovleva, E1
Simpson, MR1
Pedersen, SA1
Munblit, D1
Vallersnes, OM1
Austad, B1
Brunson, DC1
Miller, KA1
Matheson, LW1
Carrillo, E1
Liu, AR1
Lin, ZJ1
Wei, M1
Tang, Y1
Zhang, H2
Peng, XG1
Li, Y5
Zheng, YF1
Tan, Z1
Zhou, LJ1
Feng, X1
Dutton, M1
Can, AT1
Lagopoulos, J1
Hermens, DF1
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Butelman, ER1
Ball, JW1
Harris, TJ1
Kreek, MJ1
Schulte, H2
Graven-Nielsen, T2
Sollevi, A3
Jansson, Y1
Segerdahl, M3
Pelissier, T1
Alvarez, P1
Hernández, A1
Prommer, E2
Shimoyama, N2
Takahashi, H2
Shimoyama, M2
Pahl, I1
Clark, DJ1
Schmelz, M1
Barbi, E2
Marchetti, F1
Gerarduzzi, T1
Neri, E1
Gagliardo, A1
Sarti, A1
Ventura, A1
Hocking, G1
Cousins, MJ1
Mannion, S1
O'Brien, T1
Magdalena, CM1
Navarro, VP1
Park, DM1
Stuani, MB1
Rocha, MJ1
Rogers, R1
Wise, RG1
Painter, DJ1
Longe, SE1
Tracey, I1
Read, MR1
Wootton, M1
Kvarnström, A1
Karlsten, R2
Quiding, H1
Gordh, T1
Vaculín, S1
Rokyta, R1
Gottrup, H2
Bach, FW2
Jensen, TS5
Porro, CA1
Cavazzuti, M1
Giuliani, D1
Vellani, V1
Lui, F1
Baraldi, P1
McCartney, CJ1
Sinha, A1
Katz, J1
Carr, DB2
Goudas, LC2
Denman, WT2
Brookoff, D2
Staats, PS2
Brennen, L1
Green, G1
Albin, R1
Hamilton, D1
Rogers, MC1
Firestone, L1
Lavin, PT2
Mermelstein, F1
Meyer, S2
Aliani, S1
Graf, N2
Gottschling, S2
Van Elstraete, AC1
Lebrun, T1
Sandefo, I1
Polin, B1
Tobias, JD1
Subramaniam, K1
Subramaniam, B1
Steinbrook, RA1
Kotlińska-Lemieszek, A1
Luczak, J1
Zhang, GH1
Min, SS1
Lee, KS1
Back, SK1
Yoon, SJ1
Yoon, YW1
Na, HS1
Hong, SK1
Han, HC1
Blackburn, JP1
Lynch, EM1
Clark, JA1
Heinrich, M1
Wetzstein, V1
Muensterer, OJ1
Till, H1
Huang, C3
Li, HT1
Shi, YS2
Han, JS3
Wan, Y2
Fujino, Y1
Fukui, M1
Nosaka, S1
Matsumoto, T1
Chang, AS1
Larkin, T1
Stienen, PJ1
van den Brom, WE1
de Groot, HN1
Venker-van Haagen, AJ1
Hellebrekers, LJ1
Himmelseher, S1
Durieux, ME1
Mahajan, R1
Batra, YK2
Kumar, S1
Khosravi, MB1
Azemati, S1
Azemati, M1
Khosravi, A1
Lee, IO2
Lee, IH2
Lee, KC1
Strigo, IA1
Duncan, GH1
Bushnell, CM1
Boivin, M1
Wainer, I1
Rodriguez Rosas, EM1
Fitzgibbon, EJ2
Viola, R2
Good, P1
Tullio, F1
Jackson, K1
Goodchild, C1
Ashby, M1
Long, H1
Evans, D1
Turnham, L1
Barbour, K1
Kobe, J1
Wilson, L1
Vandebeek, C1
Montgomery, CJ1
Rogers, P1
Pasero, C1
McCaffery, M1
Altunkaya, H1
Ozer, Y1
Demirel, CB1
Ciçek, E1
Al Qattan, AR1
Marzouk, HM1
Smilka, M1
Agzamov, A1
Wedmore, IS1
Johnson, T1
Czarnik, J1
Hendrix, S1
Takada, M1
Fukusaki, M1
Terao, Y1
Kanaide, M1
Yamashita, K1
Matsumoto, S1
Sumikawa, K1
Lynch, ME1
Clark, AJ1
Sullivan, MJ1
Mistraletti, G1
Donatelli, F1
Carli, F1
Troost, D1
Wegener, JT1
Kruis, MR1
van der Vegt, MH1
Suzuki, M1
Kinoshita, T1
Kikutani, T1
Yokoyama, K1
Inagi, T1
Sugimoto, K1
Haraguchi, S1
Hisayoshi, T1
Shimada, Y1
Inomata, S1
Kakiuchi, Y1
Miyabe, M1
Ohara, Y1
Sukegawa, I1
Osaka, Y1
Kohda, Y1
Toyooka, H1
Krenn, T1
Reinhard, H1
Lothschuetz, D1
Nunold, H1
Mangione, S1
Pharo, GH1
Zhou, L1
Pozzi, A1
Traverso, F1
Petrenko, AB1
Yamakura, T1
Askalany, AR1
Kohno, T1
Sakimura, K1
Baba, H1
Losek, JD1
Reid, S1
Joó, G1
Mizuno, J2
Ann, Y1
Kawamura, G1
Asahara, M1
Sekiyama, H1
Arita, H1
Hanaoka, K1
Heinz, P1
Geelhoed, GC1
Wee, C1
Pascoe, EM1
Yamamoto, S1
Honda, M1
Tanabe, M1
Ono, H1
Juhl, G1
Legge, J1
Ball, N1
Elliott, DP1
Christoph, T1
Schiene, K1
Englberger, W1
Parsons, CG1
Chizh, BA2
Borker, A1
Ambulkar, I1
Gopal, R1
Advani, SH1
Hama, A1
Basler, A1
Sagen, J1
Badina, L1
Norbedo, S1
Visser, E1
Schug, SA1
Polizzotto, MN1
Bryan, T1
Ashby, MA1
Martin, P1
Wiffen, PJ1
Sprenger, T1
Valet, M1
Woltmann, R1
Zimmer, C1
Freynhagen, R1
Kochs, EF1
Tölle, TR2
Wagner, KJ1
Bertollo, CM1
Oliveira, AC1
Rocha, LT1
Costa, KA1
Nascimento, EB1
Coelho, MM1
Luhmann, JD1
Schootman, M1
Luhmann, SJ1
Kennedy, RM2
Dobrogowski, J1
Wordliczek, J1
Przewłocka, B1
White, M1
Shah, N1
Lindley, K1
Lloyd-Thomas, A1
Thomas, M1
Loryman, B1
Davies, F1
Chavada, G1
Coats, T1
Baad-Hansen, L1
Juhl, GI1
Brandsborg, B1
Svensson, P2
Koo, SW1
Cho, SJ1
Kim, YK1
Ham, KD1
Hwang, JH1
Loh, G1
Dalen, D1
Anand, KJ2
Wu, J1
Galinski, M1
Dolveck, F1
Combes, X1
Limoges, V1
Smaïl, N1
Pommier, V1
Templier, F1
Catineau, J1
Lapostolle, F1
Adnet, F1
Lago, P1
Ancora, G1
Bellieni, CV1
Cavazza, A1
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Guadagni, AM1
Memo, L1
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Pirelli, A1
Garg, S1
Rovnaghi, CR1
Narsinghani, U1
Bhutta, AT2
Hall, RW1
Karmarkar, A1
Kaabachi, O1
Chettaoui, O1
Ouezini, R1
Abdelaziz, AB1
Cherif, R1
Kokki, H1
Miller, MA1
Harrison, BP1
Tabboush, Z1
Wax, D1
Castrillon, EE1
Cairns, BE1
Ernberg, M1
Sessle, BJ1
Karsli, C1
Spiller, J1
Svenson, JE1
Abernathy, MK1
Guindon, J1
Walczak, JS1
Beaulieu, P1
Friedrichsdorf, SJ1
Kang, TI1
Slavik, VC1
Zed, PJ1
Lyon, F1
Dabbs, T1
O'Meara, M1
Van Zundert, J1
Van Boxem, K1
Saadawy, I1
Ertok, E1
Boker, A1
Tosun, Z1
Esmaoglu, A1
Coruh, A1
Sinner, B1
Graf, BM1
Capel, MM1
Jenkins, R1
Jefferson, M1
Thomas, DM1
Campbell-Fleming, JM1
Kiefer, RT1
Rohr, P1
Ploppa, A1
Dieterich, HJ1
Grothusen, J1
Koffler, S1
Altemeyer, KH1
Unertl, K1
Schwartzman, RJ1
Guedj, E1
Cammilleri, S1
Colavolpe, C1
de Laforte, C1
Niboyet, J1
Mundler, O1
Ugur, F1
Gulcu, N1
Boyaci, A1
Eichenberger, U1
Neff, F1
Sveticic, G1
Björgo, S1
Petersen-Felix, S3
Curatolo, M1
Peterbauer, C1
Larenza, PM1
Knobloch, M1
Mevissen, M1
Dykstra, LA1
Rust, M1
Kolb, E1
Benad, G1
Arndt, H1
Bion, JF1
Fishburne, JI1
Clements, JA1
Nimmo, WS1
Grant, IS1
Tomemori, N1
Komatsu, T1
Shingu, K1
Urabe, N1
Seo, N1
Mori, K1
Clark, JL1
Kalan, GE1
Bak, P1
Bjerring, P1
Zbinden, AM2
Rawal, N1
Hartvig, P1
Valtysson, J1
Lindner, KJ1
Kristensen, J1
Gustafsson, LL2
Svensson, JO2
Oye, I8
Antoni, G1
Neugebauer, V2
Lücke, T2
Schaible, HG2
Bushnell, TG1
Craig, J1
Lökken, P1
Bakstad, OJ1
Fonnelöp, E1
Skogedal, N1
Hellsten, K1
Bjerkelund, CE1
Storhaug, K1
Grubb, B1
Ekblom, A1
Ansem, RP1
Hartman, JA1
Foudraine, JF1
van Loenen, E1
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Laird, D1
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Backonja, M1
Arndt, G1
Gombar, KA1
Check, B1
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Price, DD1
Hayes, RL1
Lu, J1
Mayer, DJ1
Frenk, H1
Kibelbek, MJ1
Schwartz, JA1
Tenedios, G1
Uchida, H1
Kishikawa, K1
Collins, JG2
Hansen, G1
McGaraughty, S1
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Tsoukatos, J1
Eide, PK2
Stenehjem, AE1
Sörensen, J3
Bengtsson, A2
Bäckman, E1
Henriksson, KG3
Bengtsson, M3
Park, KM1
Max, MB3
Robinovitz, E1
Gracely, RH2
Bennett, GJ3
Byas-Smith, MG1
Gurnani, A1
Sharma, PK1
Rautela, RS1
Bhattacharya, A1
Yang, CY1
Wong, CS2
Chang, JY1
Ho, ST2
Cherng, CH1
Qian, J1
Brown, SD1
Carlton, SM2
Felsby, S1
Nielsen, J2
Puidupin, M1
Le Guern, G1
Le Marec, C1
Caroff, P1
Belat, C1
Muller, A1
Lemos, D1
Knox, DJ1
McLeod, BJ1
Goucke, CR1
Broadley, KE1
Kurowska, A1
Tookman, A1
Schnider, TW1
Rabben, T2
Fagerlund, TH1
Chaplan, SR1
Malmberg, AB1
Yaksh, TL1
Wood, T1
Sloan, R1
Breivik, H2
Nikolajsen, L1
Hansen, PO1
Meller, ST1
Baylis, R1
Stannard, C1
De Conno, F1
Polastri, D1
Ahlner, J1
Ekselius, L1
Katayama, Y1
Hirayama, T1
Tsubokawa, T1
Karpinski, N1
Dunn, J1
Hansen, L1
Masliah, E1
Hartrick, CT1
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Patterson, JS1
Davidson, EM1
Miyazaki, M1
Nanbu, T1
Yanagida, H1
Morita, S1
Tan, CH1
Onsiong, MK1
Kua, SW1
Sethna, NF1
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Fallon, MT2
O'Neill, B1
Pedersen, JL1
Galle, TS1
Kehlet, H1
Urch, CE1
Chamberlain, JH1
Hasselström, J1
Wiklund, B1
Heller, A1
Makin, MK1
Ellershaw, JE1
Rauch, DA1
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Miller, JP1
Jaffe, DM1
Slonim, AD1
Ognibene, FP1
Joubert, K1
McArdle, P1
Skjelbred, P1
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Inturrisi, CE1
Enarson, MC1
Hays, H1
Woodroffe, MA1
Gilron, I1
Quirion, R1
Coderre, TJ1
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Katz, Y1
Shalev, E1
Haines, DR1
Gaines, SP1
Guirimand, F1
Dupont, X1
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Holloway, VJ1
Husain, HM1
Saetta, JP1
Gautam, V1
Mitchell, AC3
Sang, CN1
Pellier, I1
Monrigal, JP1
Le Moine, P1
Rod, B1
Rialland, X1
Granry, JC1
Lebrun, P1
Manil, J1
Colin, F1
Raghu Raman, TS1
Deshmukh, J1
Mustola, ST1
Rorarius, MG1
Baer, GA1
Rosenberg, P1
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Harmoinen, A1
Kendall, SA1
Johnson, A1
Gerdle, B1
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Cao, Y1
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Machida, K1
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Maier, P1
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Muller, D1
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Clinical Trials (95)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Ketamine Versus Fentanyl for Surgical Abortions: A Randomized Controlled Noninferiority Trial[NCT04871425]Phase 4110 participants (Actual)Interventional2021-04-27Completed
Ultrasound Guided Versus Fluoroscopy Guided Lumber Sympathetic Block in Chronic Lower Limb Ischemia[NCT06073795]60 participants (Anticipated)Observational2023-11-01Not yet recruiting
Paravertebral Block Versus Simultaneous Ketamine and Lidocaine Infusions for Pain Management in Rib Fracture Patients[NCT04413799]Early Phase 1170 participants (Anticipated)Interventional2020-09-01Recruiting
Impact of Night-time Dexmedetomidine-esketamine Infusion on Sleep Quality of Patients With Mechanical Ventilation in ICU: a Randomized Controlled Trial[NCT05718024]Phase 4174 participants (Anticipated)Interventional2023-12-31Not yet recruiting
Dexmedetomidine-esketamine Combined With Oxycodone for Ultrasound-guided Percutaneous Radiofrequency Ablation in Patients With Liver Cancer: a Randomized Controlled Study[NCT06003218]88 participants (Anticipated)Interventional2023-10-16Recruiting
Effects of Low-dose Dexmedetomidine-esketamine Combined Nasal Administration at Night on Perioperative Sleep Quality in Breast Cancer Patients: a Randomized, Double-blind, Placebo-controlled Trial[NCT05732064]Phase 4180 participants (Anticipated)Interventional2023-05-22Recruiting
Pilot Study: Ketamine for Acute Pain After Rattlesnake Envenomation[NCT05379179]Phase 440 participants (Anticipated)Interventional2022-06-20Enrolling by invitation
Effects of Low-dose S-ketamine on the Incidence of Postpartum Depression in Women With Prenatal Depression: a Randomized, Double-blind, Placebo-controlled Trial[NCT04414943]364 participants (Actual)Interventional2020-06-19Completed
Comparison of Sub-dissociative Intranasal Ketamine Plus Standard Pain Therapy Versus Standard Pain Therapy in the Treatment of Pediatric Sickle Cell Disease Vasoocclusive Crises in Resource-limited Settings: a Multi-centered, Randomized, Controlled Trial[NCT02573714]160 participants (Anticipated)Interventional2015-12-31Recruiting
A pRospective, Case-controlled Evaluation of oLIceridine for Moderate or sEVEre Pain in Patients With Acute Burn Injuries. (RELIEVE)[NCT05465226]Phase 431 participants (Actual)Interventional2023-04-01Completed
Intravenous Sub-dissociative Dose Ketamine Injection Versus Infusion for Analgesia in the Emergency Department: A Prospective, Randomized, Double-blind Placebo Controlled Trial[NCT02916927]Phase 462 participants (Actual)Interventional2016-09-30Completed
Initiating Ketamine in Acutely Suicidal Patients in the Emergency Department[NCT04260607]Phase 32 participants (Actual)Interventional2020-01-14Terminated (stopped due to As a busy MTF we were unable to retain a health care provider with the appropriate expertise to buy-in to this study once the initiating PI left military service.)
Comparison of Ketamine 0.1 mg/kg, 0.2 mg/kg, and 0.3 mg/kg Intravenous Doses for Acute Pain in the Emergency Department: A Prospective, Randomized, Double-blind, Active-controlled, Clinical Trial[NCT03896230]Phase 411 participants (Actual)Interventional2019-05-03Terminated (stopped due to Due to resource limitations the study was on hold and was then terminated.)
Patient Satisfaction With Subdissociative Dose Ketamine Versus Morphine for Emergency Department Pain Control[NCT04698772]32 participants (Actual)Observational2019-12-19Completed
Analgesic Effects of Low-dose S-ketamine in Patients Undergoing Major Spine Fusion Surgery: A Double-blinded, Randomized Controlled Trial[NCT04964219]Phase 4164 participants (Anticipated)Interventional2022-02-08Recruiting
The Effect and Contribution of a Perioperative Ketamine Infusion in an Established Enhanced Recovery Pathway[NCT04625283]Phase 41,544 participants (Anticipated)Interventional2021-04-12Enrolling by invitation
A Randomized Controlled Trial of Intranasal Sub-dissociative Dosing of Ketamine Compared to Intranasal Fentanyl for Treatment of Pain Associated With Acute Extremity Injuries in Children[NCT02778880]Phase 390 participants (Actual)Interventional2016-03-31Completed
A Double Blind, Placebo Controlled, Fixed-Flexible Dose Clinical Trial of Guanfacine Extended Release for the Reduction of Aggression and Self-injurious Behavior Associated With Prader-Willi Syndrome[NCT05657860]Phase 433 participants (Anticipated)Interventional2020-12-17Recruiting
Prehospital Analgesia With Intra-Nasal Ketamine[NCT02753114]Phase 4120 participants (Actual)Interventional2017-11-06Completed
An Open-Label Clinical Trial of Simultaneous Administration of Oral Aspirin and Ketamine as Adjunct to Oral Antidepressant Therapy in Treatment-Resistant Depression[NCT05615948]Phase 420 participants (Anticipated)Interventional2022-12-06Recruiting
Comparison of Sub-dissociative Dose Intranasal Ketamine to Intranasal Fentanyl for Treatment of Moderate to Severe Pain in Pediatric Patients Presenting to the Emergency Department: a Prospective, Randomized, Double-blind Study[NCT02388321]Phase 422 participants (Actual)Interventional2015-05-01Terminated (stopped due to Patients meeting inclusion criteria was low, and PI went to another institution.)
Ketamine For Acute Treatment of Pain in Emergency Department[NCT02306759]Phase 460 participants (Actual)Interventional2015-01-31Completed
Comparing the Effectiveness of Low-dose Ketamine With Morphine to Treat Pain in Patients With Long Bone Fractures[NCT02430818]13 participants (Actual)Interventional2015-04-30Terminated (stopped due to were not able to enroll patients to a satisfactory level)
Adjuvant Low-dose Ketamine in Pediatric Sickle Cell Vaso-occlusive Crisis (AKTSS)[NCT03296345]Phase 262 participants (Actual)Interventional2016-06-30Completed
A Randomized Controlled Trial to Determine the Efficacy of Ketamine as an Adjunct for Pain Management in Patients With Sickle Cell Crisis[NCT03502421]Phase 30 participants (Actual)Interventional2018-09-01Withdrawn (stopped due to Never IRB approved, no intention to proceed with the study)
Ketamine Infusion for Acute Sickle Cell crisiS in the Emergency Department[NCT02417298]12 participants (Actual)Interventional2015-11-30Terminated (stopped due to Feasibility)
Music as a Potential Intervention to Improve Hemodynamic Tolerability of Repetitive Sub-Anesthetic IV Ketamine Infusions in Bipolar and Unipolar Depression: A Pilot Study[NCT04701866]32 participants (Actual)Interventional2021-01-11Completed
(2R,6R)-Hydroxynorketamine a Novel Therapeutic Analgesic for the Treatment of Neuropathic Pain: A Randomized Double Blind Cross-Over Trial.[NCT05864053]Phase 1/Phase 225 participants (Anticipated)Interventional2024-01-31Not yet recruiting
Inhaled Nebulised S(+)-Ketamine for Postoperative Analgesia[NCT02397356]Phase 40 participants (Actual)Interventional2018-08-31Withdrawn (stopped due to Lack of study personnel)
A Randomized, Clinical Trial of Oral Midazolam Plus Placebo Versus Oral Midazolam Plus Oral Ketamine for Sedation During Laceration Repair[NCT01470157]Phase 460 participants (Anticipated)Interventional2011-07-31Recruiting
A Combination Study With Sub-Dissociative Ketamine and Fentanyl to Treat Moderate to Severe Pain in the Emergency Department[NCT03959852]Phase 46 participants (Actual)Interventional2019-11-18Terminated (stopped due to Residency completed.)
Antipruritic Effect of Topical Ketamine, Amitriptyline, and Lidocaine[NCT03096444]Phase 213 participants (Actual)Interventional2017-05-23Terminated (stopped due to Efficacy was not seen after interim analysis)
IN Dexmedetomidine for Procedural Sedation in Pediatric Closed Reductions for Distal Forearm Fractures. Timmons Z MD, Feudale B MD Children Presenting to the ED With Distal Forearm Extremity Fractures Often Require Re-alignment Under Conscious Sedation. T[NCT03466242]Early Phase 140 participants (Anticipated)Interventional2018-05-01Not yet recruiting
Pilot Study on the Assessment of Motor Imaging Skills in Patients With Complex Regional Pain Syndrome (CRPS)[NCT04703348]129 participants (Actual)Interventional2021-01-12Completed
Comparison of Gut Microbial Composition and Function in CRPS Patients vs. Healthy Individuals[NCT05473338]250 participants (Anticipated)Observational2022-04-14Active, not recruiting
Comparison of Intravenous Push Dose of Low Dose Ketamine to Short Infusion of Low Dose Ketamine for Treatment of Moderate to Severe Pain in the Emergency Department: A Prospective, Randomized, Double-Blind Study[NCT02363270]48 participants (Actual)Interventional2015-04-01Completed
Intraoperative Low-dose Ketamine Infusion as the Main Analgesic in Burn Patients[NCT03049930]Phase 446 participants (Anticipated)Interventional2018-02-27Recruiting
Low-Dose Ketamine Versus Morphine for Moderate to Severe Pain in the Emergency Department Geriatric Population: A Prospective, Randomized, Double-Blind Study.[NCT02673372]Phase 460 participants (Actual)Interventional2016-04-30Completed
Prospective Observational Evaluation of a New Protocol for Adult Procedural Sedation With Ketamine-propofol in a 1 on 4 Ratio at the Emergency Department of a Tertiary Hospital[NCT04028141]61 participants (Actual)Observational2018-02-01Completed
Randomized Controlled Trial of Intranasal Ketamine Compared to Intranasal Fentanyl for Analgesia in Children With Suspected, Isolated Extremity Fractures in the Pediatric Emergency Department[NCT02521415]Phase 287 participants (Actual)Interventional2015-12-31Completed
Intranasal Ketamine for Acute Traumatic Pain in the Emergency Department: A Prospective, Randomized Clinical Trial of Efficacy and Safety[NCT02817477]Phase 490 participants (Actual)Interventional2012-09-30Completed
A Pilot Study of the Use of Oral Ketamine for Treatment of Vaso-Occlusive Pain in Adolescents and Young Adults[NCT05378555]Phase 310 participants (Anticipated)Interventional2023-05-01Recruiting
Treatment of Severe Mucositis Pain With Oral Ketamine Mouthwash[NCT01566448]Phase 230 participants (Actual)Interventional2012-02-29Completed
ED Treatment of Suicidal Patients With Ketamine Infusion[NCT03502551]Phase 20 participants (Actual)Interventional2019-04-01Withdrawn (stopped due to Trial never received funding.)
Will Warm Patch on the Injecting Site Decrease the Injection Pain Induced by Propofol[NCT04555980]120 participants (Actual)Interventional2020-03-20Completed
Comparison of Ultrasound Guided Femoral Nerve Blockade and Standard Parenteral Opioid Pain Management Alone in Patients With Hip Fracture in the Emergency Department[NCT02381717]60 participants (Anticipated)Interventional2015-08-31Recruiting
Managing Acute Pain in Critically Ill Non-communicative Palliative Care Patients[NCT02127086]377 participants (Actual)Interventional2015-03-31Completed
Analgesic Effect of Ketamine in Patients Undergoing Hysteroscopic Endometrial Thermal Ablation Surgery[NCT01106846]22 participants (Actual)Interventional2010-03-31Terminated (stopped due to Resources not available to complete.)
Oral Ketamine for Control of Chronic Pain in Children[NCT01369680]Phase 112 participants (Actual)Interventional2011-05-31Completed
Changes of the Short Portable Mental Status Questionnaire (SPMSQ-E) After Ketamine Administration on Ophthalmic Surgery in Geriatric Population.[NCT02049411]Phase 280 participants (Actual)Interventional2013-06-30Completed
Ketofol Versus Fentofol for Procedural Sedation of Children 3 to 17 Years Old: a Double-Blind Randomized Controlled Trial[NCT02079090]Phase 330 participants (Actual)Interventional2014-07-31Completed
Optimal Lidocaine Propofol Mixture for Painless Induction of Anesthesia[NCT05898061]100 participants (Anticipated)Observational [Patient Registry]2023-03-01Recruiting
Low Dose Ketamine Versus Morphine for Moderate to Severe Pain in the Emergency Department: A Prospective, Randomized, Double-Blind Study[NCT01835262]Phase 490 participants (Actual)Interventional2013-04-30Completed
Prospective Longitudinal Study on the Treatment Outcomes of Various Treatment Modalities Under a Standardized Treatment Protocol in Patients Suffered Substance Abuse Related Voiding Dysfunction[NCT03913819]1,000 participants (Anticipated)Observational2011-12-10Recruiting
Virtual Reality for Alleviation of Peripheral IV Placement-Associated Discomfort[NCT03740607]100 participants (Anticipated)Interventional2019-03-01Recruiting
Low Dose Ketamine Infusion for Comorbid Posttraumatic Stress Disorder and Chronic Pain Patients[NCT04322968]Phase 341 participants (Actual)Interventional2018-01-09Completed
Nitrous Oxide as Treatment for Fibromyalgia[NCT05357066]Phase 250 participants (Anticipated)Interventional2021-11-12Recruiting
The Check Trial: A Comparison of Headache Treatment in the ED: Compazine Versus Ketamine. A Multi-Center, Randomized Double-Blind, Clinical Control Trial.[NCT02657031]Phase 454 participants (Actual)Interventional2016-03-17Completed
Comparison of N2O Inhalation and Ketamine IV Injection for Sedation in the Treatment of Laceration of Pediatric Patients.[NCT00834730]Phase 432 participants (Actual)Interventional2009-01-31Completed
Efficacy of S(+)-Ketamine Administered as a Continuous Infusion for the Control of Postoperative Pain: a Randomized Controlled Trial[NCT02421913]Phase 442 participants (Actual)Interventional2012-06-30Completed
Study of the Efficiency of the Ketamine With Low Analgesic Doses, in Association With High Opioids, in the Treatment of the Rebels Pains, in Palliative Phase of the Cancerous Disease[NCT01326325]Phase 324 participants (Actual)Interventional2011-07-31Completed
Low-dose Ketamine as Adjuvant Treatment to Morphine in Neuropathic Cancer Pain[NCT01951911]Phase 30 participants (Actual)Interventional2013-09-30Withdrawn (stopped due to Poor patient recruitment. Vast majority of the patients have exclusions criteria)
Personalizing Perioperative Morphine Analgesia for Adolescents Undergoing Major Spine Surgeries[NCT01839461]137 participants (Actual)Observational2009-07-31Completed
Assessment of the Analgesic Efficacy and Tolerability of the Perioperative Association of the Ketamine With Opiates After Posterior Vertebral Fusion Surgery in Children With Idiopathic Scoliosis[NCT02571491]Phase 248 participants (Actual)Interventional2012-01-31Completed
Administration of Acetazolamide to Prevent Remifentanil Induced Hyperalgesia: Randomize Double Blind Clinical Trial[NCT02992938]Phase 450 participants (Actual)Interventional2016-12-31Completed
Can Opioid-induced Hyperalgesia be Prevented by Gradual Dose Reduction vs. Abrupt Withdrawal of Remifentanil?[NCT01702389]Phase 416 participants (Actual)Interventional2012-10-31Completed
Comparison of Ketamine Versus Co-Administration of Ketamine and Propofol for Procedural Sedation in a Pediatric Emergency Department[NCT01387139]Phase 3183 participants (Actual)Interventional2011-01-31Completed
Spreading Depolarization and Ketamine Suppression[NCT02501941]Phase 110 participants (Actual)Interventional2015-07-31Completed
Phenomics and Genomics of Clinically Relevant Chronic Postsurgical Pain: A Multicenter Prospective Study[NCT04798573]10,000 participants (Anticipated)Observational2012-08-03Active, not recruiting
Conscious Dying/Conscious Living: Ketamine-Assisted Psychotherapy (KAP) for Patients at End of Life-A Pilot Study for Palliative and Hospice Care[NCT05214417]Phase 2120 participants (Anticipated)Interventional2022-05-01Not yet recruiting
PCA Ketamine-Morphine Versus PCA Morphine as Post-Operative Analgesia in Colorectal Surgery.[NCT06010056]Phase 460 participants (Actual)Interventional2018-04-05Completed
A Prospective, Randomized, Double-Blind, Controlled Trial Evaluating the Efficacy of Ketamine for Improvement in Postoperative Pain Control After Spinal Fusion for Idiopathic Scoliosis[NCT02651324]Phase 450 participants (Anticipated)Interventional2013-05-31Active, not recruiting
Does a Single Intravenous Dose of Ketamine Reduce the Need for Supplemental Opioids in Post-Cesarean Section Patients?[NCT00486902]188 participants (Actual)Interventional2006-07-31Completed
Intra-operative Use of Ketamine for Post-Operative Analgesia in Patients Undergoing Hemorrhoidectomy: A Prospective, Randomized Controlled Trial.[NCT04248205]Phase 4100 participants (Anticipated)Interventional2020-06-15Recruiting
Effect of Perioperative i.v. Low-dose S(+) Ketamine in Patients Undergoing Hemorrhoidectomy[NCT00354029]Phase 483 participants (Actual)Interventional2006-08-31Completed
Intranasal Ketamine Versus Subcutaneous Ketamine for Treatment of Post Traumatic Acute Pain in the Emergency Department[NCT05229055]Phase 2/Phase 31,000 participants (Anticipated)Interventional2023-04-15Recruiting
Plasma Concentrations of Ketamine and Norketamine in Patients Using Topical Application of 10% Ketamine for Neuropathic Pain.[NCT01385904]15 participants (Anticipated)Observational2011-06-30Recruiting
Systemic Absorption of Lidocaine After Ultrasound Guided Hematoma Block for Reduction of Different Types of Pediatric Distal Radius Fractures[NCT04359017]Phase 40 participants (Actual)Interventional2020-11-01Withdrawn (stopped due to Sponsoring staff have left institution)
Patient Input Monitoring of Pain in the Emergency Room: Novel Electronic Log (PIMPERNEL). A Randomised Controlled Trial of an Electronic Pain Score Display in Adults in the Emergency Department[NCT03881982]105 participants (Actual)Interventional2017-08-03Completed
Low Dose Ketamine as an Adjunct to Opiates for Acute Pain in the Emergency Department[NCT02489630]Phase 4116 participants (Actual)Interventional2013-09-30Completed
Combination Ketamine and Propofol vs Propofol for Emergency Department Sedation: A Prospective Randomized Trial[NCT01269307]99 participants (Actual)Interventional2010-06-30Completed
The Evaluation of the Combination of Magnesium and Lidocaine for the Pretreatment of Pain That is Caused by the Injection of Propofol.[NCT01342510]Phase 4200 participants (Actual)Interventional2011-04-30Completed
Intravenous Sedation and Analgesia Using Propofol, Fentanyl and Ketamine (PFK) Versus General Anesthesia in Minor Urological Procedures.[NCT04285528]200 participants (Actual)Interventional2019-04-17Completed
The Pharmacokinetics of Ketamine in the Breast Milk of Lactating Women: Quantification of Ketamine and Metabolites[NCT04285684]Early Phase 14 participants (Actual)Interventional2019-12-20Completed
The Use of Ketamine as Rescue Analgesia in the Recovery Room Following Opioid Administration. A Double-blind Randomised Trial in Postoperative Patients.[NCT00163969]Phase 440 participants Interventional2002-04-30Completed
A Safe Ketamine-Based Therapy for Treatment Resistant Depression[NCT01179009]20 participants (Actual)Interventional2012-04-30Completed
Evaluation of the Efficiency of a Therapeutic Education Program in Standardized Thermal Cure for Fibromyalgia Patients[NCT02406313]152 participants (Actual)Interventional2015-03-31Active, not recruiting
Effects of Perioperative Systemic Ketamine on Development of Long-term Neuropathic Pain After Thoracotomy.[NCT00313378]Phase 378 participants (Actual)Interventional2004-04-30Completed
Magnesium Oral Supplementation to Reduce Pain in Patients With Severe Peripheral Arterial Occlusive Disease: The MAG-PAPER Randomized Clinical Trial[NCT02455726]150 participants (Anticipated)Interventional2015-09-30Not yet recruiting
Analgesic Efficacy of Ropivacaine Alone or in Combination With Adjuvants on Post-operative Analgesia Following Video-Assisted Thoracoscopic Surgery (VATS) - A Randomized Controlled Trial.[NCT03809442]Phase 4120 participants (Anticipated)Interventional2019-06-25Recruiting
Ketamine Versus Etomidate for Procedural Sedation for Pediatric Orthopedic Reductions[NCT00596050]Phase 450 participants (Actual)Interventional2006-08-31Completed
Efficacy of Memantine in the Treatment of Fibromyalgia: a Double-blind Randomized Trial[NCT01653457]Phase 360 participants (Anticipated)Interventional2012-09-30Not yet recruiting
Influence of Sevoflurane and Propofol on Maximum Muscular Strength, Speed of Contraction and Relaxation, in Humans: A Pilot Study[NCT05615025]Phase 348 participants (Actual)Interventional2023-01-20Completed
Naloxone Block of Low-dose (Analgetic Dose) Ketamine[NCT00921765]Phase 43 participants (Actual)Interventional2009-12-31Terminated (stopped due to Problems with patient recruitment)
Music in Urgent and Emergent Settings (MUES) Trial: Phase Two[NCT02363179]1,107 participants (Actual)Interventional2015-05-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Number of Participants Administered Additional Pain Medications

After the procedure, research personnel will ask anesthetist what medications, if any, they gave outside of the study protocol (NCT04871425)
Timeframe: Immediately postoperatively

InterventionParticipants (Count of Participants)
Ketamine23
Fentanyl30

Provider Satisfaction With Anesthesia Assessed by the VAS

After the procedure, research personnel will assess provider's satisfaction with patient's anesthesia on a 100mm visual analog scale. The minimum score is 0mm and the maximum score if 100mm, with higher scores indicating higher satisfaction. (NCT04871425)
Timeframe: Immediately postoperatively

Interventionscore on a scale (Mean)
Ketamine90
Fentanyl86.8

Satisfaction With Anesthesia Assessed by the ISAS

After the procedure, either at time of discharge (if less than 30 minutes) or at 30 minutes (if not yet discharged), research personnel will assess the participant's satisfaction with anesthesia using the Iowa Satisfaction with Anesthesia Scale. This is a validated perioperative anesthesia satisfaction scale with a minimum score of -3 and a maximum score of +3 with higher scores indicating higher satisfaction. (NCT04871425)
Timeframe: At discharge or 30 minutes after the procedure

Interventionscore on a scale (Mean)
Ketamine2.4
Fentanyl2.2

Postoperative Pain Assessed by the VAS

Patients will complete 2 followup surveys asking about their postoperative pain after discharge. This will be assessed on a 100mm visual analog scale. The minimum score is 0mm and the maximum score if 100mm, with higher scores indicating higher pain levels. (NCT04871425)
Timeframe: 24 hours postoperatively and 7 days postoperatively

,
Interventionscore on a scale (Mean)
Pain post-op day 1Pain post-op day 7
Fentanyl2219.1
Ketamine24.518.2

Side Effects

The difference in percentage of participants endorsing side effects between each arm of the study over 60 minutes. (NCT02916927)
Timeframe: 0 - 60 minutes

InterventionParticipants (Count of Participants)
Ketamine IV Infusion21
Ketamine IV Push25

How Bothersome Are the Side Effects?

"The difference in how bothersome (0, not bothersome, to 4, very bothersome, on the Side Effect Rating Scale for Dissociative Anesthetics SERSDA) the side effects experienced by participants in each arm of the study are at 5, 10, 15, 20, 30, 45, and 60 minutes.~0 (no side effects), 1 (weak), 2 (moderate), 3 (bothersome) to 4 (very bothersome)" (NCT02916927)
Timeframe: 5, 10, 15, 20, 30, 45, 60 minutes

,
Interventionscore on a scale (Mean)
Fatigue at 5 minutesFatigue at 10 minutesFatigue at 15 minutesFatigue at 20 minutesFatigue at 30 minutesFatigue at 45 minutesFatigue at 60 minutesDizziness at 5 minutesDizziness at 10 minutesDizziness at 15 minutesDizziness at 20 minutesDizziness at 30 minutesDizziness at 45 minutesDizziness at 60 minutesHeadache at 5 minutesHeadache at 10 minutesHeadache at 15 minutesHeadache at 20 minutesHeadache at 30 minutesHeadache at 45 minutesHeadache at 60 minutesUnreality at 5 minutesUnreality at 10 minutesUnreality at 15 minutesUnreality at 20 minutesUnreality at 30 minutesUnreality at 45 minutesUnreality at 60 minutesHearing at 5 minutesHearing at 10 minutesHearing at 15 minutesHearing at 20 minutesHearing at 30 minutesHearing at 45 minutesHearing at 60 minutesVision at 5 minutesVision at 10 minutesVision at 15 minutesVision at 20 minutesVision at 30 minutesVision at 45 minutesVision at 60 minutesMood at 5 minutesMood at 10 minutesMood at 15 minutesMood at 20 minutesMood at 30 minutesMood at 45 minutesMood at 60 minutesDiscomfort at 5 minutesDiscomfort at 10 minutesDiscomfort at 15 minutesDiscomfort at 20 minutesDiscomfort at 30 minutesDiscomfort at 45 minutesDiscomfort at 60 minutesHallucinations at 5 minutesHallucinations at 10 minutesHallucinations at 15 minutesHallucinations at 20 minutesHallucinations at 30 minutesHallucinations at 45 minutesHallucinations at 60 minutes
Ketamine IV Infusion0.10.40.30.30.10.20.20.50.60.50.50.30.20.20.20.10.20.10.20.20.10.30.60.50.50.20.10.0300.20.10.20.10000.10.10.10.1000.10.20.20.20.20.30.10.10.10.10.030.20.20.200.100.10.100
Ketamine IV Push0.20.30.20.20.20.10.31.40.90.70.60.20.20.20.10.20.30.20.20.30.21.60.90.40.10.030.0300.20.10.10.20.100.040.30.30.10.10000.50.30.40.30.03000.40.40.40.40.30.30.30.80.50.30.1000

Reduction in Pain on Numeric Rating Scale.

"The difference in pain numeric rating score (NRS 0-10) experienced by participants in each arm of the study at 5, 10, 15, 20, 30, 45, and 60 minutes.~Pain numeric rating scale from 0 (no pain) to 10 (maximal pain)." (NCT02916927)
Timeframe: 5, 10 , 15, 20, 30, 45, 60 minutes

,
Interventionscore on a scale (Mean)
5 minutes10 minutes15 minutes20 minutes30 minutes45 minutes60 minutes
Ketamine IV Infusion6.55.44.74.34.85.35.4
Ketamine IV Push2.92.83.43.94.24.64.5

Side Effect Severity

The difference in severity of side effects (0 - 4) experienced by participants in each arm of the study at 5, 10, 15, 20, 30, 45, and 60 minutes. 0 indicates no side effects and 4 most severe side effects. (NCT02916927)
Timeframe: 5, 10, 15, 20, 30, 45, 60 minutes

,
Interventionunits on a scale (Mean)
Fatigue at 5 minutesFatigue at 10 minutesFatigue at 15 minutesFatigue at 20 minutesFatigue at 30 minutesFatigue at 45 minutesFatigue at 60 minutesDizziness at 5 minutesDizziness at 10 minutesDizziness at 15 minutesDizziness at 20 minutesDizziness at 30 minutesDizziness at 45 minutesDizziness at 60 minutesHeadache at 5 minutesHeadache at 10 minutesHeadache at 15 minutesHeadache at 20 minutesHeadache at 30 minutesHeadache at 45 minutesHeadache at 60 minutesUnreality at 5 minutesUnreality at 10 minutesUnreality at 15 minutesUnreality at 20 minutesUnreality at 30 minutesUnreality at 45 minutesUnreality at 60 minutesHearing at 5 minutesHearing at 10 minutesHearing at 15 minutesHearing at 20 minutesHearing at 30 minutesHearing at 45 minutesHearing at 60 minutesVision at 5 minutesVision at 10 minutesVision at 15 minutesVision at 20 minutesVision at 30 minutesVision at 45 minutesVision at 60 minutesMood at 5 minutesMood at 10 minutesMood at 15 minutesMood at 20 minutesMood at 30 minutesMood at 45 minutesMood at 60 minutesDiscomfort at 5 minutesDiscomfort at 10 minutesDiscomfort at 15 minutesDiscomfort at 20 minutesDiscomfort at 30 minutesDiscomfort at 45 minutesDiscomfort at 60 minutesHallucinations at 5 minutesHallucinations at 10 minutesHallucinations at 15 minutesHallucinations at 20 minutesHallucinations at 30 minutesHallucinations at 45 minutesHallucinations at 60 minutes
Ketamine IV Infusion0.40.9.60.50.20.30.30.81.11.11.00.40.20.20.20.10.30.20.30.20.20.91.51.41.10.50.20.10.10.30.30.40.2000.030.20.20.10.1000.81.21.41.20.90.60.30.10.10.10.20.10.20.20.030.10.030.10.100
Ketamine IV Push0.60.70.70.40.30.40.52.21.91.10.90.40.30.30.20.30.30.20.20.30.32.62.21.30.80.20.100.60.20.20.10.100.040.70.40.20.10.03001.72.32.01.20.60.30.10.40.41.00.40.30.20.30.90.70.40.1000

Side Effects

The difference in percentage of participants endorsing side effects between each arm of the study at 5, 10, 15, 20, 30, 45, and 60 minutes. (NCT02916927)
Timeframe: 5, 10, 15, 20, 30, 45, 60 minutes

,
Interventionparticipants (Number)
5 minutes10 minutes15 minutes20 minutes30 minutes45 minutes60 minutes
Ketamine IV Infusion101716131398
Ketamine IV Push20181512955

Adverse Events

"Frequency of adverse events secondary to ketamine including fatigue, dizziness, nausea, headache, feeling of unreality, changes in hearing or vision, mood changes, generalized discomfort, and hallucinations, changes in vital signs.~Adverse events were reported at baseline and then at 15 min/30 min/60 min/90 min and 120 minutes post-infusion." (NCT03896230)
Timeframe: Within 2 hours post infusion completion

,,
Interventionparticipants (Number)
at 15 min post infusionat 30 min post infusionat 60 min post infusionat 90 min post infusionat 120 min post infusion
Arm 1: 0.1 mg/kg Ketamine21111
Arm 1: 0.2 mg/kg Ketamine32220
Arm 1: 0.3 mg/kg Ketamine21000

Pain Score

"Pain score using Numerical Rating Scale (NRS) post ketamine infusion. The Numerical Rating Scale (NRS) ranges from 0-to-10 with 0 being no pain and lower numbers representing less pain, so in this case lower numbers will represent better outcomes.~Pain scores were reported at baseline and then at 15 min/30 min/60 min/90 min and 120 minutes post-infusion." (NCT03896230)
Timeframe: Within 2 hours post infusion completion

,
Interventionscore on a scale (Mean)
Baseline pain scorePain score at 15 minPain score at 30 minPain score at 60 minPain score at 90 min
Arm 1: 0.3 mg/kg Ketamine7.52652
Arm 1: 0.2 mg/kg Ketamine8.565.7577

Pain Score

"Pain score using Numerical Rating Scale (NRS) post ketamine infusion. The Numerical Rating Scale (NRS) ranges from 0-to-10 with 0 being no pain and lower numbers representing less pain, so in this case lower numbers will represent better outcomes.~Pain scores were reported at baseline and then at 15 min/30 min/60 min/90 min and 120 minutes post-infusion." (NCT03896230)
Timeframe: Within 2 hours post infusion completion

Interventionscore on a scale (Mean)
Baseline pain scorePain score at 15 minPain score at 30 minPain score at 60 minPain score at 90 minPain score at 120 min
Arm 1: 0.1 mg/kg Ketamine9.45.255.255.254.54

Capnometry Value

(NCT02778880)
Timeframe: 15 minutes after study medication

InterventionmmHg (Mean)
Ketamine36.6
Fentanyl38.3

Capnometry Value

(NCT02778880)
Timeframe: 30 minutes after study medication

InterventionmmHg (Mean)
Ketamine38.6
Fentanyl40.4

Capnometry Value

(NCT02778880)
Timeframe: 60 minutes after study medication

InterventionmmHg (Mean)
Ketamine38.7
Fentanyl38.9

Diastolic Blood Pressure

(NCT02778880)
Timeframe: 15 minutes after study medication

InterventionmmHg (Mean)
Ketamine76.1
Fentanyl73.4

Diastolic Blood Pressure

(NCT02778880)
Timeframe: 30 minutes after study medication

InterventionmmHg (Mean)
Ketamine76.3
Fentanyl73.6

Diastolic Blood Pressure

(NCT02778880)
Timeframe: 60 minutes after study medication

InterventionmmHg (Mean)
Ketamine70.8
Fentanyl70.6

Difference From Baseline in Visual Analog Scale Pain Score

A VAS score is a self reported pain score of 0-100 millimeters (0 = no pain; 100 = worst possible pain). A decrease in a VAS score indicates a decrease in pain severity. (NCT02778880)
Timeframe: 15 minutes after study medication

Interventionscore on a scale (Mean)
Ketamine-24.4
Fentanyl-25.3

Difference From Baseline in Visual Analog Scale Pain Score

A VAS score is a self reported pain score of 0-100 millimeters (0 = no pain; 100 = worst possible pain). A decrease in a VAS score indicates a decrease in pain severity. (NCT02778880)
Timeframe: 30 minutes after study medication

Interventionscore on a scale (Mean)
Ketamine-30.6
Fentanyl-31.9

Difference From Baseline in Visual Analog Scale Pain Score

A VAS score is a self reported pain score of 0-100 millimeters (0 = no pain; 100 = worst possible pain). A decrease in a VAS score indicates a decrease in pain severity. (NCT02778880)
Timeframe: 60 minutes after study medication

Interventionscore on a scale (Mean)
Ketamine-27.7
Fentanyl-29.0

Heart Rate

(NCT02778880)
Timeframe: 15 minutes after study medication

Interventionbeats per minute (Mean)
Ketamine90.1
Fentanyl84.4

Heart Rate

(NCT02778880)
Timeframe: 30 minutes after study medication

Interventionbeats per minute (Mean)
Ketamine90.5
Fentanyl85.6

Heart Rate

(NCT02778880)
Timeframe: 60 minutes after study medication

Interventionbeats per minute (Mean)
Ketamine85.1
Fentanyl82.9

Oxygen Saturation

(NCT02778880)
Timeframe: 15 minutes after study medication

Interventionpercent (Mean)
Ketamine99.6
Fentanyl99.2

Oxygen Saturation

(NCT02778880)
Timeframe: 30 minutes after study medication

Interventionpercent (Mean)
Ketamine99.5
Fentanyl99.4

Oxygen Saturation

(NCT02778880)
Timeframe: 60 minutes after study medication

Interventionpercent (Mean)
Ketamine99.3
Fentanyl99.3

Respiratory Rate

(NCT02778880)
Timeframe: 15 minutes after study medication

Interventionbreaths per minute (Mean)
Ketamine23.1
Fentanyl22.3

Respiratory Rate

(NCT02778880)
Timeframe: 30 minutes after study medication

Interventionbreaths per minute (Mean)
Ketamine23.3
Fentanyl19.9

Respiratory Rate

(NCT02778880)
Timeframe: 60 minutes after study medication

Interventionbreaths per minute (Mean)
Ketamine21.8
Fentanyl19.7

Systolic Blood Pressure

(NCT02778880)
Timeframe: 15 minutes after study medication

InterventionmmHg (Mean)
Ketamine127.3
Fentanyl127.9

Systolic Blood Pressure

(NCT02778880)
Timeframe: 30 minutes after study medication

InterventionmmHg (Mean)
Ketamine126.3
Fentanyl123.4

Systolic Blood Pressure

(NCT02778880)
Timeframe: 60 minutes after study medication

InterventionmmHg (Mean)
Ketamine122.3
Fentanyl122.0

Adverse Events at 30 Minutes

The patient were asked at 30 minutes post administration of analgesia if they experienced any side effects like nausea, vomiting, headache etc. (NCT02388321)
Timeframe: 30 minutes

InterventionParticipants (Count of Participants)
Ketamine0
Fentanyl0

Pain Score at 30 Minutes

An 11 point Likert Visual Analog Scale with 0 being no pain, 5 being moderate pain and 10 being very severe pain was verbally administered to the patient at 30 minutes post administration of analgesia. (NCT02388321)
Timeframe: 30 minutes

Interventionunits on a scale (Mean)
Ketamine3.36
Fentanyl2.09

Change From Baseline of Pain as Described by Numeric Rating Scale (NRS) [Minimum:0, Maximum 10] at 15 Minutes

Change from Baseline of Pain as described by Numeric Rating Scale (NRS) [minimum:0, maximum 10] at 15 minutes. Lower values indicate worst outcomes while higher values indicate better outcomes. (NCT02306759)
Timeframe: 15 minutes after administration of study intervention

Interventionunits on a scale (Median)
Treatment3.5
Placebo6.0

ED Length of Stay (Minutes)

ED Length of stay (minutes) throughout study period (NCT02306759)
Timeframe: throughout study completion

Interventionminutes (Mean)
Treatment267
Placebo292

Number of Participants With Adverse Events

Incidence or number of participants with adverse events. (NCT02306759)
Timeframe: during the study period

Interventionparticipants (Number)
Treatment2
Placebo4

Patient Satisfaction of Pain Control Based on a Likert Scale

Patient satisfaction of pain control based on a Likert Scale at the end of study completion, an average of 90 minutes. Scores reported out of scale of 10, 10 being most satisfied and 1 being least satisfied. (NCT02306759)
Timeframe: At the end of study period

Interventionunits on a scale (Mean)
Treatment8.57
Placebo6.05

Mean Consumption of Rescue Analgesia

(NCT02306759)
Timeframe: at designated intervals during study period (0, 15, 30, 45, 60, 75, 90, 105, 120 minutes)

,
Interventionmilligrams (Mean)
T5T15T30T45T60T75T90T105T120
Placebo00.140.2800.22000.420.42
Treatment00.230.370.07000.480.550

Number of Participants With an Adverse Effects

We will monitor for adverse effects and record for changes in vital signs including nausea and vomiting, hypotension, respiratory depression, laryngospasm, and emotional and psychological effects (emergence reactions). (NCT02430818)
Timeframe: 60 minutes

Interventionparticipants (Number)
Ketamine1
Morphine1

Pain Treatment-VAS (Visual Analog Scale)

Study outcomes involve change in participants' pain as measured by a visual analog scale. The scale is a 10 inch line from 0 to 10 inches with 10 being the most pain and 0 being no pain. There are no units on the scale; it is just a straight line from no pain (0) to the worst pain (10). We assessed at o, 15, and 60 minutes but only scored the VAS at 60 minutes. (NCT02430818)
Timeframe: At 0 minutes and 60 minutes

Interventionscore on a scale (Median)
Ketamine4
Morphine4

Would the Participant Would Consider Using the Drug Given to Them for Pain Relief in the Future

Patients will be assessed to determine whether the participant would consider using the drug given to them for pain relief in the future. It was measured on a likert scale from 1-5 with 1 being did not like and would not use the drug again to 5 being like and would definitely receive the medication again. There are no units. The numbers below are the total number of patients that completed this answer. This was only asked on patients that received medication as if they did not receive medication the answer would not make sense. The median value is the likert value on a scale of 1-5 with the standard deviation. (NCT02430818)
Timeframe: 60 minutes

Interventionunits on a scale (Median)
Ketamine4
Morphine4

Effect of Low-dose Ketamine (LDK) on Opioid Usage in the ED

Opioid usage for at least one but up to three prior patient visits in the last one year for each patient enrolled in the study was summarized, expressed as morphine equivalents in mg/kg/h, to account for different types of opioids used per patient preference, and then this was compared to the intervention group that received LDK. Percent change in opioid usage (expressed as morphine equivalents in mg/kg/h) is reported). (NCT03296345)
Timeframe: Up to one year prior and after LDK administration on day 1 of the study in the ED

Interventionpercent change (Mean)
Intervention-15

Effect of Low-dose Ketamine on Discharge Rates From the ED

"Percent discharge from the ED for intervention group and for at least one but up to three visits prior to receipt of ketamine in the last one year, were assessed. Participants were assigned a 0 if discharged or 1 if not discharged." (NCT03296345)
Timeframe: Up to one year prior to receipt of ketamine for the historical control arm/group and up to 18 months for the intervention arm/group

Interventionpercentage of participants (Number)
Intervention33
Historical Control17

Effect of Low-dose Ketamine on Pain Scores on Presentation to the ED

Patient pain scores at presentation for the enrolled encounters and for at least one but up to three visits prior to receipt of ketamine in the last one year, were assessed. At least one but up to three prior visits were averaged and compared to the intervention visit. Pain was assessed using the faces pain scale which consists of a series of line diagrams of faces with expressions of increasing distress. The score ranges from 0 (no pain) to 10 (the worst pain). (NCT03296345)
Timeframe: Up to one year prior and on presentation to the ED after LDK administration

InterventionScore on a scale (Mean)
Intervention9.23
Historical Control9.08

Effect of Low-dose Ketamine on Patient Pain Scores on Discharge From the ED/Admission to the Hospital

Patient pain scores at time of discharge from the ED/admission to the hospital for at least one but up to three visits prior to receipt of ketamine in the last one year, were assessed. At least one but up to three prior visits were averaged and compared to the intervention visit. Pain scores post receipt of ketamine are presented for the intervention group. Pain was assessed using the faces pain scale which consists of a series of line diagrams of faces with expressions of increasing distress. The score ranges from 0 (no pain) to 10 (the worst pain). (NCT03296345)
Timeframe: At time of discharge from the ED/admission to the hospital (up to one year prior and after LDK administration)

InterventionScore on a scale (Mean)
Intervention7.15
Historical Control7.26

Effect of Low-dose Ketamine on Percent Difference of Length of Stay (LOS) in the ED

Length of stay (LOS) in minutes in the ED for at least one but up to three visits prior to receipt of ketamine in the last one year, were assessed. (NCT03296345)
Timeframe: Up to one year prior to and after LDK administration on day 1 of the study in the ED

InterventionLOS in minutes (Mean)
Intervention273.5
Historical Control217.3

Effect of Low-dose Ketamine on Time to 50% Pain Reduction

Time to 50% pain reduction (pain reported 50% less than baseline) in minutes for at least one but up to three visits prior to receipt of ketamine in the last one year, were assessed as historical controls. Pain was assessed using the faces pain scale which consists of a series of line diagrams of faces with expressions of increasing distress. The score ranges from 0 (no pain) to 10 (the worst pain). (NCT03296345)
Timeframe: Up to one year prior to and after LDK administration on day 1 of the study in the ED

Interventiontime to 50% pain reduction in minutes (Mean)
Intervention116.1
Historical Control167.3

Subjective Effect of Low Dose Ketamine on Pain Relief Assessed Via a Patient Survey

"After receipt of LDK, patients and/or their parents, based on age, filled out a survey based on a Likert scale regarding their agreement (Strongly Disagree to Strongly Agree) with the following statements: Achieved faster pain relief with LDK, Achieved more complete pain relief with LDK, and Desire to receive LDK in a future vaso-occlusive crisis. There is also an area where patients could provide general comments regarding their experience in receiving LDK.~Count of Participants who agree or strongly agree for each question are reported." (NCT03296345)
Timeframe: after LDK administration on day 1 of the study in the ED

InterventionParticipants (Count of Participants)
Achieved faster pain relief?Achieved more complete pain relief?Desire to receive LDK in the future?
Intervention433049

Peak Itch Intensity Between the Vehicle and Active Treatments (Individual and KeAmLi-combo).

"Peak itch intensity between the vehicle and 4 other active treatments (individual ketamine, amitriptyline, or lidocaine, and KeAmLi-combo). Itch intensity was measured on a 100mm scale visual analog scale for 10 minutes. 0 was weighted with no itch and 100 was weighted with most itch imaginable." (NCT03096444)
Timeframe: 10 minutes

InterventionIntensity score (Mean)
Topical KeAmLi Combo62.7
Topical Ketamine63.1
Topical Amitriptyline69.2
Topical Lidocaine65.8
Topical Vehicle61.9

Mechanical Thresholds (Mechanical Detection and Pain).

Assess mechanical detection and pain thresholds using von Frey filaments stimulators (measured in force mN) to calculate the final threshold as the geometric mean of five series of ascending and descending stimuli. (NCT03096444)
Timeframe: 5 minutes

,,,,
InterventionmN (Mean)
Mechanical Detection ThresholdMechanical Pain Threshold
Topical Amitriptyline3.573423965152.4768146
Topical KeAmLi Combo3.519376956152.3293608
Topical Ketamine3.464204768135.9
Topical Lidocaine3.546037659126.9
Topical Vehicle3.525692637148.7138273

Thermal Threshold Detection (Warmth and Heat Pain)

Two standardized quantitative sensory tests are performed to measure warmth detection threshold (assesses the threshold of which warmth sensation is first detected) and heat pain threshold (assesses the threshold at which heat pain sensation is first detected). Measured in change in celsius. (NCT03096444)
Timeframe: 3 minutes

,,,,
InterventionDegrees celsius (Mean)
Warm Detection ThresholdHeat Pain Threshold
Topical Amitriptyline33.940.0
Topical KeAmLi Combo33.639.8
Topical Ketamine34.040.0
Topical Lidocaine33.739.4
Topical Vehicle33.839.7

Overall Rate of Feeling Unreality

Overall rate of feeling of unreality as measured by Side Effects Rating Scale for Dissociative Anesthetics (SERSDA) (NCT02363270)
Timeframe: 30 minutes

InterventionParticipants (Count of Participants)
IV Push Group22
IV Drip Group13

Reduction of Pain Score at 30 Minutes

The primary outcome will be the comparative reduction of NRS pain scores between the 2 groups at 30 minutes. The NRS Pain scale ranges from 0 to 10 (0 being no pain at all to 10 being very severe pain; 5 is moderate pain) (NCT02673372)
Timeframe: 30 minutes

Interventionscore on a scale (Mean)
Morphine Group4.4
Ketamine Group4.2

Exploratory Outcome: Reduction in Age Appropriate Pain Scale Scores

Mean difference in the reduction of the pain scale scores at 20 minutes. Two commonly used, age appropriate and previously validated, pediatric pain assessment tools were used: FACES Pain Scale - Revised for children ages 4-10 and the Visual Analog Scale for children ages 11-17. The FACES Pain Scale - Revised is a self-reported measure of pain intensity developed for children with pain intensity represented by images of grimacing faces on a scale of 0 (no pain) to 10 (maximum pain). The Visual Analog Scale is a self-reported measure of pain intensity where patients mark their pain level on a 10 cm line that represents a continuum of no pain at 0 cm and worst pain at 10 cm. For analysis, pain scale data were merged and reported as values form 0 to 100. The minimum clinically significant reduction in pain was defined as a decrease of 20. (NCT02521415)
Timeframe: 20 minutes

Interventionunits on a scale (Mean)
Ketamine44
Fentanyl35

Secondary Outcome: Total Dose of Opioid Pain Medication in Morphine Equivalents/kg/Hour

Compare the total dose of opioid pain medication in morphine equivalents/kg/hour required during the ED evaluation of children with suspected forearm fractures after randomization and treatment with IN ketamine or IN fentanyl. (NCT02521415)
Timeframe: participants will be followed during the emergency department length of stay, estimated to average 6 hours

Interventionmorphine equivalents/kg/hr (Median)
Ketamine0.04
Fentanyl0.05

Change in Pain Scores

Change in pain score as reported at baseline and after the use of ketamine mouthwash on a numeric scale from 0 to 10, with 0 representing no pain and 10 representing the worst pain. (NCT01566448)
Timeframe: 1 hour after baseline

Interventionscore on a scale (Median)
Ketamine2

Change in Sleep Quality

Sleep quality, as reported by the subject on a numeric scale (1-10) will be used as a surrogate marker of quality of life with 0 indicating no sleep and 10 indicating the best sleep you have had. (NCT01566448)
Timeframe: Day 1 after start of ketamine mouthwashes

Interventionscore on a scale (Median)
Ketamine1

Change in Topical Lidocaine Usage

Change of topical lidocaine uses in 24 hour period (NCT01566448)
Timeframe: Days 1 after start of ketamine mouthwashes

Interventionlidocaine doses per day (Median)
Ketamine1

Change in Use of Narcotic Analgesics

Change in IV morphine equivalents of opioid requirements (NCT01566448)
Timeframe: Days 1 after start of ketamine mouthwashes

InterventionIV morphine equivalents (Median)
Ketamine12

Quality of Recovery Score Post Operative at 24 Hours

Quality of recovery 40 score at 24 hours after the surgical procedure. 40 being a poor recovery and 200 being a good recovery. (NCT01106846)
Timeframe: 24 hours post operative

Interventionunits on scale (Mean)
Group A: Saline Group191.2
Group B: 1% Ketamine Group191.1

Neurocognitive Effect

"Baseline neurocognitive testing will be done before study drug is given. Subjects will be reassessed for any changes in neurocognitive scores at end of dosing (week 2) and at three weeks off study drug (week 14). Significant changes were measured at week 14 compared to baseline. Week 2 was measured to inform future studies.~The neurocognitive scores are standardized scores with a mean of 100; low scores correlate with low neurocognitive function, while high scores correlate with high function. A significant change is defined as greater than or equal to 10% decrease in scores." (NCT01369680)
Timeframe: At 14 weeks

Interventionparticipants (Number)
Ketamine 0.25 mg/kg/Dose0
Ketamine 0.5 mg/kg/Dose0
Ketamine 1 mg/kg/Dose0
Ketamine 1.5 mg/kg/Dose0

Norketamine Cmax (Measured in ng/mL).

Pharmacokinetic testing will be done during chronic ketamine administration on subjects consenting to additional testing one week into study drug administration. This is to further describe the activity of ketamine in the blood of children when administered chronically and to enable comparison of any clinical effect or toxicity with steady state levels of ketamine in children. (NCT01369680)
Timeframe: At week 1

Interventionng/mL (Mean)
Ketamine 0.25 mg/kg/Dose37.5
Ketamine 0.5 mg/kg/Dose135
Ketamine 1 mg/kg/Dose250

Number of Participants Tolerating Dose

According to CTCae any dose causing grade 2 or worse toxicity will be an untolerated dose. Tolerability is defined as ability to take the medication for 2 weeks without having a grade 2 or worse toxicity. (NCT01369680)
Timeframe: Up to 2 weeks

Interventionparticipants (Number)
Ketamine 0.25 mg/kg/Dose3
Ketamine 0.5 mg/kg/Dose3
Ketamine 1 mg/kg/Dose3
Ketamine 1.5 mg/kg/Dose1

Pain Control

"Subjects will be assessed for clinically significant change in pain scores during and after study drug administration. Significant change in pain scores were determined at week 2, though week 14 scores were collected as well.~Participants with a 2 point (or greater) decrease in pain scores compared to baseline were considered to have responded. The NRS scale was used, the scale ranges from 0-10, with 10 being the most pain." (NCT01369680)
Timeframe: Week 2

Interventionparticipants (Number)
Ketamine 0.25 mg/kg/Dose3
Ketamine 0.5 mg/kg/Dose0
Ketamine 1 mg/kg/Dose2
Ketamine 1.5 mg/kg/Dose0

Numeric Rating Scale of Pain

"We will compare efficacy as a difference between 2 groups in pain score at 30 minutes post-analgesic administration. The primary outcome is the difference between 2 groups in pain score at 30 minutes.~Pain will be measured via Numeric rating scale from 0 to 10 with 0 being no pain, 5 being moderate pain, and 10 being severe pain" (NCT01835262)
Timeframe: 30 minutes

InterventionUnits on a scale (Mean)
Morphine3.93
Ketamine Group4.07

Impact of Event Scale-Revised (IES-R)

"Severity of PTSD symptoms; items are rated on a 5-point scale ranging from 0 (not at all) to 4 (extremely). The IES-R yields a total score (ranging from 0 to 88); higher scores mean worse symptoms" (NCT04322968)
Timeframe: 1 week post-infusion

Interventionunits on a scale (Mean)
Chronic Pain With PTSD+IV Ketamine Infusion28.22
Chronic Pain With PTSD+IV Ketorolac Infusion33.66666667
Chronic Pain Without PTSD+IV Ketamine Infusion11.44
Chronic Pain Without PTSD+IV Ketorolac Infusion13.41

Impact of Event Scale-Revised (IES-R)

"Severity of PTSD symptoms; items are rated on a 5-point scale ranging from 0 (not at all) to 4 (extremely). The IES-R yields a total score (ranging from 0 to 88); higher scores mean worse symptoms" (NCT04322968)
Timeframe: 24 hrs post-infusion

Interventionunits on a scale (Mean)
Chronic Pain With PTSD+IV Ketamine Infusion36.33333333
Chronic Pain With PTSD+IV Ketorolac Infusion37
Chronic Pain Without PTSD+IV Ketamine Infusion10.44444444
Chronic Pain Without PTSD+IV Ketorolac Infusion15.64705882

Visual Analogue Scale (VAS)

"Severity of chronic pain symptoms; using a ruler, the score is determined by measuring the distance (mm) on the 10-cm line between the no pain anchor and the patient's mark, providing a range of scores from 0-100; a higher score indicates greater pain intensity." (NCT04322968)
Timeframe: 1 week post-infusion

Interventionunits on a scale (Mean)
Chronic Pain With PTSD+IV Ketamine Infusion48.22
Chronic Pain With PTSD+IV Ketorolac Infusion52.88
Chronic Pain Without PTSD+IV Ketamine Infusion43.33
Chronic Pain Without PTSD+IV Ketorolac Infusion48.23

Visual Analogue Scale (VAS)

"Severity of chronic pain symptoms; using a ruler, the score is determined by measuring the distance (mm) on the 10-cm line between the no pain anchor and the patient's mark, providing a range of scores from 0-100; a higher score indicates greater pain intensity." (NCT04322968)
Timeframe: 24 hrs post-infusion

Interventionunits on a scale (Mean)
Chronic Pain With PTSD+IV Ketamine Infusion37.22222222
Chronic Pain With PTSD+IV Ketorolac Infusion49.66666667
Chronic Pain Without PTSD+IV Ketamine Infusion29.88888889
Chronic Pain Without PTSD+IV Ketorolac Infusion38.70588235

Brief Pain Inventory (Short Form)

"Severity of pain, impact of pain on daily function, location of pain, pain medications and amount of pain relief in the past 24 hours or the past week; No scoring algorithm, but worst pain or the arithmetic mean of the four severity items can be used as measures of pain severity (a range of 0-10, with 10 being worse scores); the arithmetic mean of the seven interference items can be used as a measure of pain interference (a range of 0-10, with 10 being worse scores). The total score is reported for severity items and interference items, which range from 0-40 and 0-70, respectively. Higher values represent worse outcome." (NCT04322968)
Timeframe: 1 week post-infusion

,,,
Interventionunits on a scale (Mean)
Pain interference ScalePain severity Scale
Chronic Pain With PTSD+IV Ketamine Infusion38.6220.75
Chronic Pain With PTSD+IV Ketorolac Infusion25.6614.66
Chronic Pain Without PTSD+IV Ketamine Infusion9.6212.75
Chronic Pain Without PTSD+IV Ketorolac Infusion28.3322.66

Anxiety

Reduction in 100 mm Visual Analog Scale (VAS) Score. The maximum possible change in VAS score is 100 mm, representing the complete relief of maximum anxiety. A change of 0 mm corresponds to no change in anxiety level, and a negative value indicates worsening of the anxiety after the medication. (NCT02657031)
Timeframe: 0-60 minutes

Interventionmm (Mean)
Control Arm33.7
Study Arm21.2

Headache Following Intervention

Reduction in 100 mm Visual Analog Scale (VAS) Score. Positive values represent a reduction in headache severity. The maximum possible change in VAS score is 100 mm, representing the complete relief of a maximally severe headache. A change of 0 mm corresponds to no change in headache severity, and a negative value indicates worsening of the headache after the medication. (NCT02657031)
Timeframe: 0-60 minutes

Interventionmm (Mean)
Control Arm63.5
Study Arm43.5

Nausea

Reduction in 100 mm Visual Analog Scale (VAS) Score. The maximum possible change in VAS score is 100 mm, representing the complete relief of maximum nausea. A change of 0 mm corresponds to no change in nausea level, and a negative value indicates worsening of the nausea after the medication. (NCT02657031)
Timeframe: 0-60 minutes

Interventionmm (Mean)
Control Arm38.9
Study Arm22.9

The Number of Participants Experiencing Vomiting

Yes/No (NCT02657031)
Timeframe: 0-60 minutes

Interventionparticipants (Number)
Control Arm2
Study Arm3

The Number of Patients Experiencing Restlessness

Yes/No (NCT02657031)
Timeframe: 0-60 minutes

Interventionparticipants (Number)
Control Arm3
Study Arm3

Efficacy of Sedation

"Efficacy is defined as:~The patient does not have unpleasant recall of the procedure.~The patient did not experience sedation-related adverse events resulting in abandonment of the procedure or a permanent complication or an unplanned admission to the hospital or prolonged emergency department (ED) observation~The patient did not actively resist or require physical restraint for completion of the procedure. The need for minimal redirection of movements should not be considered as active resistance or physical restraint.~The procedure was successful" (NCT01387139)
Timeframe: After procedure is completed, on average less than 1 hour

Interventionparticipants (Number)
Ketamine Alone97
Ketamine Co-Administered With Propofol81

Nurse Satisfaction

Measured on a 10-point scale (1= least satisfied, 10= most satisfied) (NCT01387139)
Timeframe: After procedure is completed, on average less than 1 hour

Interventionunits on a scale (Median)
Ketamine Alone10
Ketamine Co-Administered With Propofol8

Parent Satisfaction

Measured on a 10-point scale (1= least satisfied, 10= most satisfied) (NCT01387139)
Timeframe: After procedure is completed, on average less than 1 hour

Interventionunits on a scale (1-10) (Median)
Ketamine Alone10
Ketamine Co-Administered With Propofol10

Physician Performing Procedure Satisfaction

Measured on a 10-point scale (1= least satisfied, 10= most satisfied) (NCT01387139)
Timeframe: After procedure is completed, on average less than 1 hour

Interventionunits on a scale (Median)
Ketamine Alone9
Ketamine Co-Administered With Propofol8

Recovery Time

Time until the patient has a Vancouver Sedation Recovery Scale Score of 18 or greater. (NCT01387139)
Timeframe: Once Vancouver Sedation Recovery Scale Score reaches 18 or greater, on average less than 1 hour

Interventionminutes (Median)
Ketamine Alone44
Ketamine Co-Administered With Propofol43.5

Frequency of Adverse Events

We will record all adverse events during the sedation, and then perform a follow-up call to determine if any additional adverse events occured after discharge. (NCT01387139)
Timeframe: From enrollment through completion of follow-up, up to 7 days

,
Interventionparticipants (Number)
Respiratory depressionCardiovascular eventvomiting/retchingUnpleasant recovery reaction
Ketamine Alone121214
Ketamine Co-Administered With Propofol150182

Cumulative Hydrocodone/Acetaminophen for Supplemental Analgesia to Treat Breakthrough Pain

Cumulative hydrocodone/acetaminophen for supplemental analgesia to treat breakthrough pain for 72 hours following cesarean delivery (NCT00486902)
Timeframe: 72 hours

Interventiontablets (Median)
Ketamine10
Placebo9

Disturbing Dreams

Number of subject reporting disturbing dreams at 72 hours post cesarean delivery (NCT00486902)
Timeframe: 72 hours

Interventionparticipants (Number)
Ketamine0
Placebo0

Number of Subjects Requiring Supplemental Analgesia in the First 24 Hours Following Cesarean Delivery

Request for oral hydrocodone/acetaminophen for pain not controlled by around the clock non-steroidal antiflammatory drugs in the first 24 hours following cesarean delivery. (NCT00486902)
Timeframe: 24 hours

Interventionparticipants (Number)
Ketamine64
Placebo66

Pain Score (0-10) at 2 Weeks Following Cesarean Delivery

Numeric rating for pain score (0 to 10) reported at 2 weeks following cesarean delivery. Zero is no pain and 10 is worst pain imaginable. (NCT00486902)
Timeframe: 2 weeks

InterventionScores on a scale (Median)
Ketamine2
Placebo2.6

Postoperative Nausea

Number of subjects reporting nausea in first 24 hours following cesarean delivery (NCT00486902)
Timeframe: 24 hours

Interventionparticipants (Number)
Ketamine27
Placebo30

Postoperative Vomiting

Number of subjects that vomited in the first 24 hours following cesarean delivery (NCT00486902)
Timeframe: 24 hours

Interventionparticipants (Number)
Ketamine13
Placebo13

Postperative Pruritus

Number of subjects with pruritus in the first 24 hours following cesarean delivery (NCT00486902)
Timeframe: 24 hours

Interventionparticipants (Number)
Ketamine12
Placebo19

Verbal Pain Scores (0 to 10) at First Analgesia Request

Numeric rating of pain scores (NRS) scale (0 to 10) at time of supplemental analgesia request. Zero is no pain and 10 is worst pain imaginable. (NCT00486902)
Timeframe: 24 hours

InterventionScores on a scale (Median)
Ketamine3
Placebo4

NRS Pain = Numeric Rating Scale (0-10)

The numeric rating scale (NRS) is used to measure the intensity of pain. The value 0 means no pain and the value 10 represents maximal pain. a higher intensity of pain is associated with a worse outcome. (NCT00354029)
Timeframe: 24 hours

InterventionUnits on a scale (Mean)
S (+) Ketamine1.6
Placebo1.5

Change in Level of Pain Control as Reported on the NRS-11

"Patient-reported pain scores on numerical rating scale (NRS) -11 pain scale (where 0 indicates no pain at all, 10 indicates the most severe pain). Initial group were patients enrolled and randomized in to the study, assessments were taken at the time of enrollment/randomization in to the study (up to 20 min prior to T=0). T = 0 min assessments were conducted at the time of medication administration (study allowed for an up to 20-minute delay in receiving study drug in order to retrieve study drug from secure storage, nursing documentation and patient verification prior to administration)." (NCT02489630)
Timeframe: 20 min pre-medication administration, 0 min, 30 min, 60 min, 90 min, 120 min post medication administration

,
InterventionUnits on a scale (1-10) (Mean)
InitialT = 0 minT = 30 minT = 60 minT = 90 minT = 120 min
Ketamine9.387.515.255.314.514.24
Placebo9.448.102.276.186.215.68

Change in Patient Satisfaction With Pain Control on a 1-4 Likert Scale

Patient-reported score regarding satisfaction with pain control, reported on a 4-point Likert scale (1-4, where 1 is the lowest satisfaction score possible and 4 is the highest satisfaction score possible). No data is reported for T = 0 min, as that assessment was conducted concurrently with initial medication dosing (since patients were at that point receiving their first pain control efforts, they could not yet assess their satisfaction with those efforts). (NCT02489630)
Timeframe: 0 min, 30 min, 60 min, 90 min, 120 min post medication administration

,
InterventionUnits on a scale (1-4) (Mean)
T = 30 minT = 60 minT = 90 minT = 120 min
Ketamine2.092.382.542.66
Placebo2.272.332.382.52

Difference in Opiate Dosage Between Study Arms in Morphine Equivalents

"Average difference in opiate dosage between study arms, calculated in morphine equivalents. Initial indicates at first dose of opioid administration, up to 20 mins prior to study drug administration, and from 0 min to 120 min after study drug administration." (NCT02489630)
Timeframe: 20 mins pre-medication administration, 0 min, 30 min, 60 min, 90 min, 120 min post medication administration

,
InterventionMilligrams of Morphine Equivalent (Mean)
Initial Narcotic DosageTotal Narcotic Dosage
Ketamine5.419.95
Placebo5.8312.81

Number of Patients With Pain Associated With Injection of Propofol.

"Ten seconds following injection of propofol, subjects were asked Are you having pain at your IV site? Any behavioral signs were noted. Injection pain was assessed using the following four point scale: 0 = no pain; 1 = mild pain (pain reported only in response to questioning and without behavioral signs); 2 = moderate pain (pain reported in response to questioning and accompanied by a behavioral sign, or pain reported spontaneously without questioning); and 3 = severe pain (strong vocal response or response accompanied by facial grimacing, arm withdrawal, or tears)." (NCT01342510)
Timeframe: < 1 minute.

Interventionparticipants reporting pain (Number)
Lidocaine11
Magnesium25
Lidocaine/Magnesium15
Control18

Percentage of Participants Reporting Pain With Injection of Propofol

Following injection of the study drug, 50 mg of propofol will be injected. Ten seconds after propofol, subjects will be asked a standard question about pain. Behavioral signs will be noted. Pain will be assessed using a four point scale: 0=no pain, 1=mild pain (pain reported only in response to questioning and without behavioral signs), 2=moderate pain (pain reported in response to questioning and a behavioral sign, or pain reported without questioning), 3=severe pain (strong vocal response or behavioral response). (NCT01342510)
Timeframe: Approximately 10 seconds following administration of propofol.

Interventionpercentage of patients reporting pain (Number)
Lidocaine29
Magnesium57
Lidocaine/Magnesium41
Control46

Dehydronorketamine Concentration in Breast Milk at 24 and 30 Hours After an IM Administration of 1mg/kg Ketamine

"Quantitative analysis of the concentration of ketamine and its metabolites in breast milk (collected by pumping breast milk into containers at 24 and 30 hours post ketamine IM administration) was performed at the Clinical Medicine and Toxicology Laboratory at UCSF School of Medicine. Sample aliquots were frozen in our conventional freezer at the clinic where the sessions took place, labelled with a HIPAA compliant code which blinded the lab to all patient data.~The limits of sensitivity for the quantification of each substance were:~Ketamine: 0.25 ng Norketamine: 0.25 ng Dehydronorketamine: 0.1 ng Hydroxynorketamine: 0.25 ng" (NCT04285684)
Timeframe: 24 and 30 hour collections

Interventionng/mL (Mean)
24 Hours30 Hours
Ketamine During Lactation.3.3

Dehydronorketamine Concentration in Breast Milk, up to 12 Hours at 3 Hour Intervals, Following an IM Administration of .5mg/kg Ketamine

"Quantitative analysis of the concentration of ketamine and its metabolites in breast milk (collected by pumping breast milk into containers at 3, 6, 9, and 12 hours post ketamine IM administration) was performed at the Clinical Medicine and Toxicology Laboratory at UCSF School of Medicine. Sample aliquots were frozen in our conventional freezer at the clinic where the sessions took place, labelled with a HIPAA compliant code which blinded the lab to all patient data.~The limits of sensitivity for the quantification of each substance were:~Ketamine: 0.25 ng Norketamine: 0.25 ng Dehydronorketamine: 0.1 ng Hydroxynorketamine: 0.25 ng" (NCT04285684)
Timeframe: 3, 6, 9, and 12 hour collections

Interventionng/mL (Mean)
3 Hours6 Hours9 Hours12 Hours
Ketamine During Lactation.56.55.45.21

Dehydronorketamine Concentration in Breast Milk, up to 12 Hours at 3 Hour Intervals, Following an IM Administration of 1mg/kg Ketamine

"Quantitative analysis of the concentration of ketamine and its metabolites in breast milk (collected by pumping breast milk into containers at 3, 6, 9, and 12 hours post ketamine IM administration) was performed at the Clinical Medicine and Toxicology Laboratory at UCSF School of Medicine. Sample aliquots were frozen in our conventional freezer at the clinic where the sessions took place, labelled with a HIPAA compliant code which blinded the lab to all patient data.~The limits of sensitivity for the quantification of each substance were:~Ketamine: 0.25 ng Norketamine: 0.25 ng Dehydronorketamine: 0.1 ng Hydroxynorketamine: 0.25 ng" (NCT04285684)
Timeframe: 3, 6, 9, and 12 hour collections

Interventionng/mL (Mean)
3 Hours6 Hours9 Hours12 Hours
Ketamine During Lactation2.01.91.41.1

Hydroxynorketamine Concentration in Breast Milk at 24 and 30 Hours After an IM Administration of 1mg/kg Ketamine

"Quantitative analysis of the concentration of ketamine and its metabolites in breast milk (collected by pumping breast milk into containers at 24 and 30 hours post ketamine IM administration) was performed at the Clinical Medicine and Toxicology Laboratory at UCSF School of Medicine. Sample aliquots were frozen in our conventional freezer at the clinic where the sessions took place, labelled with a HIPAA compliant code which blinded the lab to all patient data.~The limits of sensitivity for the quantification of each substance were:~Ketamine: 0.25 ng Norketamine: 0.25 ng Dehydronorketamine: 0.1 ng Hydroxynorketamine: 0.25 ng" (NCT04285684)
Timeframe: 24 and 30 hour collections

Interventionng/mL (Mean)
24 Hours30 Hours
Ketamine During Lactation30.513.9

Hydroxynorketamine Concentration in Breast Milk, up to 12 Hours at 3 Hour Intervals, Following an IM Administration of .5mg/kg Ketamine

"Quantitative analysis of the concentration of ketamine and its metabolites in breast milk (collected by pumping breast milk into containers at 3, 6, 9, and 12 hours post ketamine IM administration) was performed at the Clinical Medicine and Toxicology Laboratory at UCSF School of Medicine. Sample aliquots were frozen in our conventional freezer at the clinic where the sessions took place, labelled with a HIPAA compliant code which blinded the lab to all patient data.~The limits of sensitivity for the quantification of each substance were:~Ketamine: 0.25 ng Norketamine: 0.25 ng Dehydronorketamine: 0.1 ng Hydroxynorketamine: 0.25 ng" (NCT04285684)
Timeframe: 3, 6, 9, and 12 hour collections

Interventionng/mL (Mean)
3 Hours6 Hours9 Hours12 Hours
Ketamine During Lactation29.928.325.617.5

Hydroxynorketamine Concentration in Breast Milk, up to 12 Hours at 3 Hour Intervals, Following an IM Administration of 1mg/kg Ketamine

"Quantitative analysis of the concentration of ketamine and its metabolites in breast milk (collected by pumping breast milk into containers at 3, 6, 9, and 12 hours post ketamine IM administration) was performed at the Clinical Medicine and Toxicology Laboratory at UCSF School of Medicine. Sample aliquots were frozen in our conventional freezer at the clinic where the sessions took place, labelled with a HIPAA compliant code which blinded the lab to all patient data.~The limits of sensitivity for the quantification of each substance were:~Ketamine: 0.25 ng Norketamine: 0.25 ng Dehydronorketamine: 0.1 ng Hydroxynorketamine: 0.25 ng" (NCT04285684)
Timeframe: 3, 6, 9, and 12 hour collections

Interventionng/mL (Mean)
3 Hours6 Hours9 Hours12 Hours
Ketamine During Lactation64.166.954.641.6

Ketamine Concentration in Breast Milk at 24 and 30 Hours After an IM Administration of 1mg/kg Ketamine

"Quantitative analysis of the concentration of ketamine and its metabolites in breast milk (collected by pumping breast milk into containers at 24 and 30 hours post ketamine IM administration) was performed at the Clinical Medicine and Toxicology Laboratory at UCSF School of Medicine. Sample aliquots were frozen in our conventional freezer at the clinic where the sessions took place, labelled with a HIPAA compliant code which blinded the lab to all patient data.~The limits of sensitivity for the quantification of each substance were:~Ketamine: 0.25 ng Norketamine: 0.25 ng Dehydronorketamine: 0.1 ng Hydroxynorketamine: 0.25 ng" (NCT04285684)
Timeframe: 24 and 30 hour collections

Interventionng/mL (Mean)
24 Hours30 Hours
Ketamine During Lactation4.96.4

Ketamine Concentration in Breast Milk, up to 12 Hours at 3 Hour Intervals, Following an IM Administration of .5mg/kg Ketamine

"Quantitative analysis of the concentration of ketamine and its metabolites in breast milk (collected by pumping breast milk into containers at 3, 6, 9, and 12 hours post ketamine IM administration) was performed at the Clinical Medicine and Toxicology Laboratory at UCSF School of Medicine. Sample aliquots were frozen in our conventional freezer at the clinic where the sessions took place, labelled with a HIPAA compliant code which blinded the lab to all patient data.~The limits of sensitivity for the quantification of each substance were:~Ketamine: 0.25 ng Norketamine: 0.25 ng Dehydronorketamine: 0.1 ng Hydroxynorketamine: 0.25 ng" (NCT04285684)
Timeframe: 3, 6, 9, and 12 hour collections

Interventionng/mL (Mean)
3 Hours6 Hours9 Hours12 Hours
Ketamine During Lactation51.222.610.64.5

Ketamine Concentration in Breast Milk, up to 12 Hours at 3 Hour Intervals, Following an IM Administration of 1mg/kg Ketamine

"Quantitative analysis of the concentration of ketamine and its metabolites in breast milk (collected by pumping breast milk into containers at 3, 6, 9, and 12 hours post ketamine IM administration) was performed at the Clinical Medicine and Toxicology Laboratory at UCSF School of Medicine. Sample aliquots were frozen in our conventional freezer at the clinic where the sessions took place, labelled with a HIPAA compliant code which blinded the lab to all patient data.~The limits of sensitivity for the quantification of each substance were:~Ketamine: 0.25 ng Norketamine: 0.25 ng Dehydronorketamine: 0.1 ng Hydroxynorketamine: 0.25 ng" (NCT04285684)
Timeframe: 3, 6, 9, and 12 hour collections

Interventionng/mL (Mean)
3 Hours6 Hours9 Hours12 Hours
Ketamine During Lactation125.048.221.618.5

Norketamine Concentration in Breast Milk at 24 and 30 Hours After an IM Administration of 1mg/kg Ketamine

"Quantitative analysis of the concentration of ketamine and its metabolites in breast milk (collected by pumping breast milk into containers at 24 and 30 hours post ketamine IM administration) was performed at the Clinical Medicine and Toxicology Laboratory at UCSF School of Medicine. Sample aliquots were frozen in our conventional freezer at the clinic where the sessions took place, labelled with a HIPAA compliant code which blinded the lab to all patient data.~The limits of sensitivity for the quantification of each substance were:~Ketamine: 0.25 ng Norketamine: 0.25 ng Dehydronorketamine: 0.1 ng Hydroxynorketamine: 0.25 ng" (NCT04285684)
Timeframe: 24 and 30 hour collections

Interventionng/mL (Mean)
24 Hours30 Hours
Ketamine During Lactation10.39.9

Norketamine Concentration in Breast Milk, up to 12 Hours at 3 Hour Intervals, Following an IM Administration of .5mg/kg Ketamine

"Quantitative analysis of the concentration of ketamine and its metabolites in breast milk (collected by pumping breast milk into containers at 3, 6, 9, and 12 hours post ketamine IM administration) was performed at the Clinical Medicine and Toxicology Laboratory at UCSF School of Medicine. Sample aliquots were frozen in our conventional freezer at the clinic where the sessions took place, labelled with a HIPAA compliant code which blinded the lab to all patient data.~The limits of sensitivity for the quantification of each substance were:~Ketamine: 0.25 ng Norketamine: 0.25 ng Dehydronorketamine: 0.1 ng Hydroxynorketamine: 0.25 ng" (NCT04285684)
Timeframe: 3, 6, 9, and 12 hour collections

Interventionng/mL (Mean)
3 Hours6 Hours9 Hours12 Hours
Ketamine During Lactation42.628.618.88.7

Norketamine Concentration in Breast Milk, up to 12 Hours at 3 Hour Intervals, Following an IM Administration of 1mg/kg Ketamine

"Quantitative analysis of the concentration of ketamine and its metabolites in breast milk (collected by pumping breast milk into containers at 3, 6, 9, and 12 hours post ketamine IM administration) was performed at the Clinical Medicine and Toxicology Laboratory at UCSF School of Medicine. Sample aliquots were frozen in our conventional freezer at the clinic where the sessions took place, labelled with a HIPAA compliant code which blinded the lab to all patient data.~The limits of sensitivity for the quantification of each substance were:~Ketamine: 0.25 ng Norketamine: 0.25 ng Dehydronorketamine: 0.1 ng Hydroxynorketamine: 0.25 ng" (NCT04285684)
Timeframe: 3, 6, 9, and 12 hour collections

Interventionng/mL (Mean)
3 Hours6 Hours9 Hours12 Hours
Ketamine During Lactation92.762.437.332.3

Montgomery-Asberg Depression Rating Scale (MADRS) Total Score

The Montgomery-Asberg Depression Rating Scale (MADRS) is a 10-item scale that measures the severity of depression, with a higher score indicating a higher level of depression. The range of scores is 0 to 60. (NCT01179009)
Timeframe: 8 weeks

InterventionScores on a scale (Mean)
Ketamine 100-hour Infusion-9.0
Ketamine 40-minute Infusion-6.4

Reviews

119 reviews available for ketamine and Ache

ArticleYear
Low-dose Ketamine Infusion for Pediatric Hematology/Oncology Patients: Case Series and Literature Review.
    Journal of pediatric hematology/oncology, 2022, 01-01, Volume: 44, Issue:1

    Topics: Adolescent; Adult; Anemia, Sickle Cell; Child; Female; Humans; Ketamine; Male; Pain

2022
Influence of ketamine versus fentanyl on pain relief for pediatric orthopedic emergencies: A meta-analysis of randomized controlled studies.
    Medicine, 2021, Oct-22, Volume: 100, Issue:42

    Topics: Adolescent; Child; Child, Preschool; Drug Administration Routes; Emergencies; Female; Fentanyl; Huma

2021
Pharmacological treatment in adult patients with CRPS-I: a systematic review and meta-analysis of randomized controlled trials.
    Rheumatology (Oxford, England), 2022, 08-30, Volume: 61, Issue:9

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2 Inhibitors; Diphosphonates; Humans;

2022
Global Trends and Hotspots in Esketamine Research: A Bibliometric Analysis of Past and Estimation of Future Trends.
    Drug design, development and therapy, 2022, Volume: 16

    Topics: Bibliometrics; Databases, Factual; Humans; Ketamine; Pain; United States

2022
Analgesia and Sedation for Tactical Combat Casualty Care: TCCC Proposed Change 21-02.
    Journal of special operations medicine : a peer reviewed journal for SOF medical professionals, 2022, 05-31, Volume: 22, Issue:2

    Topics: Analgesia; Humans; Ketamine; Military Medicine; Pain; Pain Management

2022
Pharmacologic therapies of pain in patients with spinal cord injury: a systematic review.
    Spinal cord series and cases, 2022, 07-04, Volume: 8, Issue:1

    Topics: Amitriptyline; Anticonvulsants; Gabapentin; Humans; Ketamine; Pain; Pregabalin; Spinal Cord Injuries

2022
Patterns of Palliation: A Review of Casualties That Received Pain Management Before Reaching Role 2 in Afghanistan.
    Military medicine, 2023, 01-04, Volume: 188, Issue:1-2

    Topics: Adult; Afghan Campaign 2001-; Afghanistan; Emergency Medical Services; Fentanyl; Humans; Ketamine; M

2023
Management of Pain and Agitation in Trauma.
    Emergency medicine clinics of North America, 2023, Volume: 41, Issue:1

    Topics: Analgesics, Opioid; Humans; Ketamine; Multiple Trauma; Pain; Propofol

2023
Management of Pain and Agitation in Trauma.
    Emergency medicine clinics of North America, 2023, Volume: 41, Issue:1

    Topics: Analgesics, Opioid; Humans; Ketamine; Multiple Trauma; Pain; Propofol

2023
Management of Pain and Agitation in Trauma.
    Emergency medicine clinics of North America, 2023, Volume: 41, Issue:1

    Topics: Analgesics, Opioid; Humans; Ketamine; Multiple Trauma; Pain; Propofol

2023
Management of Pain and Agitation in Trauma.
    Emergency medicine clinics of North America, 2023, Volume: 41, Issue:1

    Topics: Analgesics, Opioid; Humans; Ketamine; Multiple Trauma; Pain; Propofol

2023
Management of Pain and Agitation in Trauma.
    Emergency medicine clinics of North America, 2023, Volume: 41, Issue:1

    Topics: Analgesics, Opioid; Humans; Ketamine; Multiple Trauma; Pain; Propofol

2023
Management of Pain and Agitation in Trauma.
    Emergency medicine clinics of North America, 2023, Volume: 41, Issue:1

    Topics: Analgesics, Opioid; Humans; Ketamine; Multiple Trauma; Pain; Propofol

2023
Management of Pain and Agitation in Trauma.
    Emergency medicine clinics of North America, 2023, Volume: 41, Issue:1

    Topics: Analgesics, Opioid; Humans; Ketamine; Multiple Trauma; Pain; Propofol

2023
Management of Pain and Agitation in Trauma.
    Emergency medicine clinics of North America, 2023, Volume: 41, Issue:1

    Topics: Analgesics, Opioid; Humans; Ketamine; Multiple Trauma; Pain; Propofol

2023
Management of Pain and Agitation in Trauma.
    Emergency medicine clinics of North America, 2023, Volume: 41, Issue:1

    Topics: Analgesics, Opioid; Humans; Ketamine; Multiple Trauma; Pain; Propofol

2023
Systematic review and meta-analysis of ketamine-associated uropathy.
    Hong Kong medical journal = Xianggang yi xue za zhi, 2022, Volume: 28, Issue:6

    Topics: Cystitis; Humans; Ketamine; Pain; Urinary Bladder; Urologic Diseases

2022
Systematic review and meta-analysis of ketamine-associated uropathy.
    Hong Kong medical journal = Xianggang yi xue za zhi, 2022, Volume: 28, Issue:6

    Topics: Cystitis; Humans; Ketamine; Pain; Urinary Bladder; Urologic Diseases

2022
Systematic review and meta-analysis of ketamine-associated uropathy.
    Hong Kong medical journal = Xianggang yi xue za zhi, 2022, Volume: 28, Issue:6

    Topics: Cystitis; Humans; Ketamine; Pain; Urinary Bladder; Urologic Diseases

2022
Systematic review and meta-analysis of ketamine-associated uropathy.
    Hong Kong medical journal = Xianggang yi xue za zhi, 2022, Volume: 28, Issue:6

    Topics: Cystitis; Humans; Ketamine; Pain; Urinary Bladder; Urologic Diseases

2022
Efficacy and safety of perioperative application of ketamine on postoperative depression: A meta-analysis of randomized controlled studies.
    Molecular psychiatry, 2023, Volume: 28, Issue:6

    Topics: Antidepressive Agents; Depression; Depressive Disorder; Humans; Ketamine; Pain; Pain, Postoperative;

2023
Non-surgical management and analgesia strategies for older adults with multiple rib fractures: A systematic review, meta-analysis, and joint practice management guideline from the Eastern Association for the Surgery of Trauma and the Chest Wall Injury Soc
    The journal of trauma and acute care surgery, 2023, 03-01, Volume: 94, Issue:3

    Topics: Aged; Analgesia, Epidural; Humans; Ketamine; Length of Stay; Neck Injuries; Pain; Pneumonia; Rib Fra

2023
A Comparison of Prehospital Pediatric Analgesic Use of Ketamine and Opioids.
    Prehospital emergency care, 2023, Volume: 27, Issue:7

    Topics: Analgesics; Analgesics, Opioid; Child; Emergency Medical Services; Humans; Ketamine; Pain; Retrospec

2023
Non-opioid analgesics for procedural pain in neonates.
    The Cochrane database of systematic reviews, 2023, 04-04, Volume: 4

    Topics: Aged; Analgesics; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Apnea; Body Wei

2023
Low-dose ketamine or opioids combined with propofol for procedural sedation in the emergency department: a systematic review.
    European journal of emergency medicine : official journal of the European Society for Emergency Medicine, 2023, Aug-01, Volume: 30, Issue:4

    Topics: Analgesics, Opioid; Conscious Sedation; Emergency Service, Hospital; Fentanyl; Humans; Hypnotics and

2023
Analysis of the efficacy of subclinical doses of esketamine in combination with propofol in non-intubated general anesthesia procedures - a systematic review and meta-analysis.
    BMC anesthesiology, 2023, 07-21, Volume: 23, Issue:1

    Topics: Anesthesia, General; Drug-Related Side Effects and Adverse Reactions; Humans; Ketamine; Pain; Propof

2023
Intranasal analgesia for acute moderate to severe pain in children - a systematic review and meta-analysis.
    BMC pediatrics, 2023, 08-18, Volume: 23, Issue:1

    Topics: Analgesia; Child; Fentanyl; Humans; Ketamine; Ketorolac; Pain

2023
Oral ketamine may offer a solution to the ketamine conundrum.
    Psychopharmacology, 2023, Volume: 240, Issue:12

    Topics: Antidepressive Agents; Biological Availability; Humans; Ketamine; Pain

2023
Use of ketamine for prehospital pain control on the battlefield: A systematic review.
    The journal of trauma and acute care surgery, 2020, Volume: 88, Issue:1

    Topics: Administration, Intravenous; Afghan Campaign 2001-; Analgesics; Blood Pressure; Dose-Response Relati

2020
Suicide Has Many Faces, So Does Ketamine: a Narrative Review on Ketamine's Antisuicidal Actions.
    Current psychiatry reports, 2019, 12-03, Volume: 21, Issue:12

    Topics: Antidepressive Agents; Humans; Inflammation; Ketamine; Neuronal Plasticity; Pain; Reward; Suicidal I

2019
Meeting the Challenge of Analgesia in a Pregnant Woman With Burn Injury Using Subanesthetic Ketamine: A Case Report and Literature Review.
    Journal of burn care & research : official publication of the American Burn Association, 2020, Jul-03, Volume: 41, Issue:4

    Topics: Adult; Analgesics; Burns; Female; Humans; Infusions, Intravenous; Ketamine; Pain; Pregnancy; Pregnan

2020
Ketamine as a Prehospital Analgesic: A Systematic Review.
    Prehospital and disaster medicine, 2020, Volume: 35, Issue:3

    Topics: Analgesics; Emergency Medical Services; Humans; Ketamine; Pain; Pain Management; Pain Measurement; W

2020
Anaesthetic management of subcutaneous abscesses: current status.
    British journal of anaesthesia, 2020, Volume: 125, Issue:2

    Topics: Abscess; Administration, Topical; Anesthesia; Anesthetics, Dissociative; Anesthetics, Local; Drainag

2020
Ketamine: a versatile tool for anesthesia and analgesia.
    Current opinion in anaesthesiology, 2020, Volume: 33, Issue:5

    Topics: Analgesia; Analgesics; Anesthesia; Anesthetics, Dissociative; Burns; Depression; Humans; Ketamine; P

2020
Ketamine: a versatile tool for anesthesia and analgesia.
    Current opinion in anaesthesiology, 2020, Volume: 33, Issue:5

    Topics: Analgesia; Analgesics; Anesthesia; Anesthetics, Dissociative; Burns; Depression; Humans; Ketamine; P

2020
Ketamine: a versatile tool for anesthesia and analgesia.
    Current opinion in anaesthesiology, 2020, Volume: 33, Issue:5

    Topics: Analgesia; Analgesics; Anesthesia; Anesthetics, Dissociative; Burns; Depression; Humans; Ketamine; P

2020
Ketamine: a versatile tool for anesthesia and analgesia.
    Current opinion in anaesthesiology, 2020, Volume: 33, Issue:5

    Topics: Analgesia; Analgesics; Anesthesia; Anesthetics, Dissociative; Burns; Depression; Humans; Ketamine; P

2020
Ketamine: a versatile tool for anesthesia and analgesia.
    Current opinion in anaesthesiology, 2020, Volume: 33, Issue:5

    Topics: Analgesia; Analgesics; Anesthesia; Anesthetics, Dissociative; Burns; Depression; Humans; Ketamine; P

2020
Ketamine: a versatile tool for anesthesia and analgesia.
    Current opinion in anaesthesiology, 2020, Volume: 33, Issue:5

    Topics: Analgesia; Analgesics; Anesthesia; Anesthetics, Dissociative; Burns; Depression; Humans; Ketamine; P

2020
Ketamine: a versatile tool for anesthesia and analgesia.
    Current opinion in anaesthesiology, 2020, Volume: 33, Issue:5

    Topics: Analgesia; Analgesics; Anesthesia; Anesthetics, Dissociative; Burns; Depression; Humans; Ketamine; P

2020
Ketamine: a versatile tool for anesthesia and analgesia.
    Current opinion in anaesthesiology, 2020, Volume: 33, Issue:5

    Topics: Analgesia; Analgesics; Anesthesia; Anesthetics, Dissociative; Burns; Depression; Humans; Ketamine; P

2020
Ketamine: a versatile tool for anesthesia and analgesia.
    Current opinion in anaesthesiology, 2020, Volume: 33, Issue:5

    Topics: Analgesia; Analgesics; Anesthesia; Anesthetics, Dissociative; Burns; Depression; Humans; Ketamine; P

2020
A review of the clinical applications of ketamine in pediatric oncology.
    Pediatric blood & cancer, 2021, Volume: 68, Issue:1

    Topics: Analgesics; Child; Humans; Ketamine; Neoplasms; Pain; Prognosis

2021
Ketamine-polymer based drug delivery system for prolonged analgesia: recent advances, challenges and future prospects.
    Expert opinion on drug delivery, 2021, Volume: 18, Issue:8

    Topics: Analgesia; Delayed-Action Preparations; Humans; Ketamine; Pain; Polymers; Quality of Life

2021
A systematic review of ketamine for the management of vaso-occlusive pain in sickle cell disease.
    Pediatric blood & cancer, 2021, Volume: 68, Issue:7

    Topics: Anemia, Sickle Cell; Humans; Ketamine; Pain; Pain Management; Pain Measurement

2021
Ketamine in the Past, Present, and Future: Mechanisms, Metabolites, and Toxicity.
    Current pain and headache reports, 2021, Jul-16, Volume: 25, Issue:9

    Topics: Animals; Forecasting; Humans; Ketamine; Pain

2021
Ketamine for Pain Management-Side Effects & Potential Adverse Events.
    Pain management nursing : official journal of the American Society of Pain Management Nurses, 2017, Volume: 18, Issue:6

    Topics: Analgesics; Drug-Related Side Effects and Adverse Reactions; Humans; Ketamine; Pain; Pain Management

2017
Principles of Burn Pain Management.
    Clinics in plastic surgery, 2017, Volume: 44, Issue:4

    Topics: Analgesics; Analgesics, Opioid; Anesthetics; Burns; Exercise Therapy; Humans; Intraoperative Care; K

2017
The Expanding Role of Ketamine in the Emergency Department.
    Drugs, 2018, Volume: 78, Issue:7

    Topics: Analgesics; Blood-Brain Barrier; Emergency Service, Hospital; Humans; Ketamine; Pain

2018
Emerging Trends in Pain Medication Management: Back to the Future: A Focus on Ketamine.
    The American journal of medicine, 2018, Volume: 131, Issue:8

    Topics: Analgesics; Chronic Pain; Humans; Ketamine; Pain; Pain Management

2018
An Update on the Basic and Clinical Science of Ketamine Analgesia.
    The Clinical journal of pain, 2018, Volume: 34, Issue:11

    Topics: Analgesics; Animals; Humans; Ketamine; Pain

2018
An Update on the Basic and Clinical Science of Ketamine Analgesia.
    The Clinical journal of pain, 2018, Volume: 34, Issue:11

    Topics: Analgesics; Animals; Humans; Ketamine; Pain

2018
An Update on the Basic and Clinical Science of Ketamine Analgesia.
    The Clinical journal of pain, 2018, Volume: 34, Issue:11

    Topics: Analgesics; Animals; Humans; Ketamine; Pain

2018
An Update on the Basic and Clinical Science of Ketamine Analgesia.
    The Clinical journal of pain, 2018, Volume: 34, Issue:11

    Topics: Analgesics; Animals; Humans; Ketamine; Pain

2018
Scientific Issues Relevant to Improving the Diagnosis, Risk Assessment, and Treatment of Major Depression.
    The American journal of psychiatry, 2019, 05-01, Volume: 176, Issue:5

    Topics: Antidepressive Agents; Anxiety; Biomedical Research; Depressive Disorder, Major; Diagnostic and Stat

2019
The Efficacy of Ketamine in the Palliative Care Setting: A Comprehensive Review of the Literature.
    Journal of palliative medicine, 2019, Volume: 22, Issue:9

    Topics: Administration, Intranasal; Administration, Intravenous; Adult; Aged; Aged, 80 and over; Antidepress

2019
Ketamine: use in anesthesia.
    CNS neuroscience & therapeutics, 2013, Volume: 19, Issue:6

    Topics: Anesthesia; Anesthetics, Dissociative; Animals; Drug Administration Routes; Emergency Service, Hospi

2013
Ketamine: use in anesthesia.
    CNS neuroscience & therapeutics, 2013, Volume: 19, Issue:6

    Topics: Anesthesia; Anesthetics, Dissociative; Animals; Drug Administration Routes; Emergency Service, Hospi

2013
Ketamine: use in anesthesia.
    CNS neuroscience & therapeutics, 2013, Volume: 19, Issue:6

    Topics: Anesthesia; Anesthetics, Dissociative; Animals; Drug Administration Routes; Emergency Service, Hospi

2013
Ketamine: use in anesthesia.
    CNS neuroscience & therapeutics, 2013, Volume: 19, Issue:6

    Topics: Anesthesia; Anesthetics, Dissociative; Animals; Drug Administration Routes; Emergency Service, Hospi

2013
Ketamine: use in anesthesia.
    CNS neuroscience & therapeutics, 2013, Volume: 19, Issue:6

    Topics: Anesthesia; Anesthetics, Dissociative; Animals; Drug Administration Routes; Emergency Service, Hospi

2013
Ketamine: use in anesthesia.
    CNS neuroscience & therapeutics, 2013, Volume: 19, Issue:6

    Topics: Anesthesia; Anesthetics, Dissociative; Animals; Drug Administration Routes; Emergency Service, Hospi

2013
Ketamine: use in anesthesia.
    CNS neuroscience & therapeutics, 2013, Volume: 19, Issue:6

    Topics: Anesthesia; Anesthetics, Dissociative; Animals; Drug Administration Routes; Emergency Service, Hospi

2013
Ketamine: use in anesthesia.
    CNS neuroscience & therapeutics, 2013, Volume: 19, Issue:6

    Topics: Anesthesia; Anesthetics, Dissociative; Animals; Drug Administration Routes; Emergency Service, Hospi

2013
Ketamine: use in anesthesia.
    CNS neuroscience & therapeutics, 2013, Volume: 19, Issue:6

    Topics: Anesthesia; Anesthetics, Dissociative; Animals; Drug Administration Routes; Emergency Service, Hospi

2013
Low-dose ketamine as a potential adjuvant therapy for painful vaso-occlusive crises in sickle cell disease.
    Paediatric anaesthesia, 2013, Volume: 23, Issue:8

    Topics: Anemia, Sickle Cell; Anesthetics, Dissociative; Arterial Occlusive Diseases; Drug Tolerance; Excitat

2013
Low-dose ketamine as a potential adjuvant therapy for painful vaso-occlusive crises in sickle cell disease.
    Paediatric anaesthesia, 2013, Volume: 23, Issue:8

    Topics: Anemia, Sickle Cell; Anesthetics, Dissociative; Arterial Occlusive Diseases; Drug Tolerance; Excitat

2013
Low-dose ketamine as a potential adjuvant therapy for painful vaso-occlusive crises in sickle cell disease.
    Paediatric anaesthesia, 2013, Volume: 23, Issue:8

    Topics: Anemia, Sickle Cell; Anesthetics, Dissociative; Arterial Occlusive Diseases; Drug Tolerance; Excitat

2013
Low-dose ketamine as a potential adjuvant therapy for painful vaso-occlusive crises in sickle cell disease.
    Paediatric anaesthesia, 2013, Volume: 23, Issue:8

    Topics: Anemia, Sickle Cell; Anesthetics, Dissociative; Arterial Occlusive Diseases; Drug Tolerance; Excitat

2013
Low-dose ketamine as a potential adjuvant therapy for painful vaso-occlusive crises in sickle cell disease.
    Paediatric anaesthesia, 2013, Volume: 23, Issue:8

    Topics: Anemia, Sickle Cell; Anesthetics, Dissociative; Arterial Occlusive Diseases; Drug Tolerance; Excitat

2013
Low-dose ketamine as a potential adjuvant therapy for painful vaso-occlusive crises in sickle cell disease.
    Paediatric anaesthesia, 2013, Volume: 23, Issue:8

    Topics: Anemia, Sickle Cell; Anesthetics, Dissociative; Arterial Occlusive Diseases; Drug Tolerance; Excitat

2013
Low-dose ketamine as a potential adjuvant therapy for painful vaso-occlusive crises in sickle cell disease.
    Paediatric anaesthesia, 2013, Volume: 23, Issue:8

    Topics: Anemia, Sickle Cell; Anesthetics, Dissociative; Arterial Occlusive Diseases; Drug Tolerance; Excitat

2013
Low-dose ketamine as a potential adjuvant therapy for painful vaso-occlusive crises in sickle cell disease.
    Paediatric anaesthesia, 2013, Volume: 23, Issue:8

    Topics: Anemia, Sickle Cell; Anesthetics, Dissociative; Arterial Occlusive Diseases; Drug Tolerance; Excitat

2013
Low-dose ketamine as a potential adjuvant therapy for painful vaso-occlusive crises in sickle cell disease.
    Paediatric anaesthesia, 2013, Volume: 23, Issue:8

    Topics: Anemia, Sickle Cell; Anesthetics, Dissociative; Arterial Occlusive Diseases; Drug Tolerance; Excitat

2013
Low-dose ketamine as a potential adjuvant therapy for painful vaso-occlusive crises in sickle cell disease.
    Paediatric anaesthesia, 2013, Volume: 23, Issue:8

    Topics: Anemia, Sickle Cell; Anesthetics, Dissociative; Arterial Occlusive Diseases; Drug Tolerance; Excitat

2013
Low-dose ketamine as a potential adjuvant therapy for painful vaso-occlusive crises in sickle cell disease.
    Paediatric anaesthesia, 2013, Volume: 23, Issue:8

    Topics: Anemia, Sickle Cell; Anesthetics, Dissociative; Arterial Occlusive Diseases; Drug Tolerance; Excitat

2013
Low-dose ketamine as a potential adjuvant therapy for painful vaso-occlusive crises in sickle cell disease.
    Paediatric anaesthesia, 2013, Volume: 23, Issue:8

    Topics: Anemia, Sickle Cell; Anesthetics, Dissociative; Arterial Occlusive Diseases; Drug Tolerance; Excitat

2013
Low-dose ketamine as a potential adjuvant therapy for painful vaso-occlusive crises in sickle cell disease.
    Paediatric anaesthesia, 2013, Volume: 23, Issue:8

    Topics: Anemia, Sickle Cell; Anesthetics, Dissociative; Arterial Occlusive Diseases; Drug Tolerance; Excitat

2013
Low-dose ketamine as a potential adjuvant therapy for painful vaso-occlusive crises in sickle cell disease.
    Paediatric anaesthesia, 2013, Volume: 23, Issue:8

    Topics: Anemia, Sickle Cell; Anesthetics, Dissociative; Arterial Occlusive Diseases; Drug Tolerance; Excitat

2013
Low-dose ketamine as a potential adjuvant therapy for painful vaso-occlusive crises in sickle cell disease.
    Paediatric anaesthesia, 2013, Volume: 23, Issue:8

    Topics: Anemia, Sickle Cell; Anesthetics, Dissociative; Arterial Occlusive Diseases; Drug Tolerance; Excitat

2013
Low-dose ketamine as a potential adjuvant therapy for painful vaso-occlusive crises in sickle cell disease.
    Paediatric anaesthesia, 2013, Volume: 23, Issue:8

    Topics: Anemia, Sickle Cell; Anesthetics, Dissociative; Arterial Occlusive Diseases; Drug Tolerance; Excitat

2013
Ketamine and peripheral inflammation.
    CNS neuroscience & therapeutics, 2013, Volume: 19, Issue:6

    Topics: Analgesics; Animals; Cognition Disorders; Humans; Inflammation; Ketamine; Pain; Postoperative Compli

2013
Ketamine in pain management.
    CNS neuroscience & therapeutics, 2013, Volume: 19, Issue:6

    Topics: Analgesics; Animals; Humans; Ketamine; Pain; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid

2013
Sedation and analgesia to facilitate mechanical ventilation.
    Clinics in perinatology, 2013, Volume: 40, Issue:3

    Topics: Analgesics; Analgesics, Opioid; Benzodiazepines; Clonidine; Humans; Hypnotics and Sedatives; Infant;

2013
Ketamine infusion for sickle cell pain crisis refractory to opioids: a case report and review of literature.
    Annals of hematology, 2014, Volume: 93, Issue:5

    Topics: Adult; Analgesics, Opioid; Anemia, Sickle Cell; Humans; Infusions, Intravenous; Ketamine; Male; Pain

2014
Ketamine infusion for sickle cell pain crisis refractory to opioids: a case report and review of literature.
    Annals of hematology, 2014, Volume: 93, Issue:5

    Topics: Adult; Analgesics, Opioid; Anemia, Sickle Cell; Humans; Infusions, Intravenous; Ketamine; Male; Pain

2014
Ketamine infusion for sickle cell pain crisis refractory to opioids: a case report and review of literature.
    Annals of hematology, 2014, Volume: 93, Issue:5

    Topics: Adult; Analgesics, Opioid; Anemia, Sickle Cell; Humans; Infusions, Intravenous; Ketamine; Male; Pain

2014
Ketamine infusion for sickle cell pain crisis refractory to opioids: a case report and review of literature.
    Annals of hematology, 2014, Volume: 93, Issue:5

    Topics: Adult; Analgesics, Opioid; Anemia, Sickle Cell; Humans; Infusions, Intravenous; Ketamine; Male; Pain

2014
Ketamine infusion for sickle cell pain crisis refractory to opioids: a case report and review of literature.
    Annals of hematology, 2014, Volume: 93, Issue:5

    Topics: Adult; Analgesics, Opioid; Anemia, Sickle Cell; Humans; Infusions, Intravenous; Ketamine; Male; Pain

2014
Ketamine infusion for sickle cell pain crisis refractory to opioids: a case report and review of literature.
    Annals of hematology, 2014, Volume: 93, Issue:5

    Topics: Adult; Analgesics, Opioid; Anemia, Sickle Cell; Humans; Infusions, Intravenous; Ketamine; Male; Pain

2014
Ketamine infusion for sickle cell pain crisis refractory to opioids: a case report and review of literature.
    Annals of hematology, 2014, Volume: 93, Issue:5

    Topics: Adult; Analgesics, Opioid; Anemia, Sickle Cell; Humans; Infusions, Intravenous; Ketamine; Male; Pain

2014
Ketamine infusion for sickle cell pain crisis refractory to opioids: a case report and review of literature.
    Annals of hematology, 2014, Volume: 93, Issue:5

    Topics: Adult; Analgesics, Opioid; Anemia, Sickle Cell; Humans; Infusions, Intravenous; Ketamine; Male; Pain

2014
Ketamine infusion for sickle cell pain crisis refractory to opioids: a case report and review of literature.
    Annals of hematology, 2014, Volume: 93, Issue:5

    Topics: Adult; Analgesics, Opioid; Anemia, Sickle Cell; Humans; Infusions, Intravenous; Ketamine; Male; Pain

2014
Analgesic effects of topical ketamine.
    Minerva anestesiologica, 2015, Volume: 81, Issue:4

    Topics: Administration, Topical; Analgesics; Humans; Ketamine; Neuralgia; Pain; Pain Management

2015
Ketamine-an update on its clinical uses and abuses.
    CNS neuroscience & therapeutics, 2014, Volume: 20, Issue:12

    Topics: Analgesics; Animals; Asthma; Depressive Disorder, Major; Gastrointestinal Tract; Humans; Ketamine; P

2014
Complex regional pain syndrome: An optimistic perspective.
    Neurology, 2015, Jan-06, Volume: 84, Issue:1

    Topics: Analgesics; Autonomic Nervous System Diseases; Bone Density Conservation Agents; Complex Regional Pa

2015
Complex regional pain syndrome: An optimistic perspective.
    Neurology, 2015, Jan-06, Volume: 84, Issue:1

    Topics: Analgesics; Autonomic Nervous System Diseases; Bone Density Conservation Agents; Complex Regional Pa

2015
Complex regional pain syndrome: An optimistic perspective.
    Neurology, 2015, Jan-06, Volume: 84, Issue:1

    Topics: Analgesics; Autonomic Nervous System Diseases; Bone Density Conservation Agents; Complex Regional Pa

2015
Complex regional pain syndrome: An optimistic perspective.
    Neurology, 2015, Jan-06, Volume: 84, Issue:1

    Topics: Analgesics; Autonomic Nervous System Diseases; Bone Density Conservation Agents; Complex Regional Pa

2015
Ameliorating treatment-refractory depression with intranasal ketamine: potential NMDA receptor actions in the pain circuitry representing mental anguish.
    CNS spectrums, 2016, Volume: 21, Issue:1

    Topics: Administration, Intranasal; Animals; Cerebral Cortex; Depressive Disorder, Treatment-Resistant; Exci

2016
Pharmacotherapy for pain: efficacy and safety issues examined by subgroup analyses.
    Pain, 2015, Volume: 156 Suppl 1

    Topics: Analgesics; Analgesics, Opioid; Animals; Capsaicin; Humans; Ketamine; Pain; Pain Measurement; Respir

2015
Ketamine.
    Journal of pain and symptom management, 2015, Volume: 50, Issue:2

    Topics: Analgesics; Animals; Hospice Care; Humans; Ketamine; Neoplasms; Pain; Palliative Care

2015
Ketamine-Propofol Versus Propofol Alone for Procedural Sedation in the Emergency Department: A Systematic Review and Meta-analysis.
    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2015, Volume: 22, Issue:9

    Topics: Conscious Sedation; Drug Therapy, Combination; Emergency Service, Hospital; Humans; Hypnotics and Se

2015
Ketamine use in current clinical practice.
    Acta pharmacologica Sinica, 2016, Volume: 37, Issue:7

    Topics: Depression; Humans; Ketamine; Pain; Pain Management; Suicide Prevention

2016
Ketamine: A Review of Clinical Pharmacokinetics and Pharmacodynamics in Anesthesia and Pain Therapy.
    Clinical pharmacokinetics, 2016, Volume: 55, Issue:9

    Topics: Analgesics; Anesthesia; Animals; Biological Availability; Central Nervous System; Child; Cytochrome

2016
Analgesia in the surgical intensive care unit.
    Postgraduate medical journal, 2017, Volume: 93, Issue:1095

    Topics: Acetaminophen; Amines; Analgesics; Analgesics, Opioid; Anesthesia, Conduction; Anesthetics, Local; C

2017
Ketamine Infusion for Pain Control in Acute Pediatric Sickle Cell Painful Crises.
    Pediatric emergency care, 2019, Volume: 35, Issue:1

    Topics: Analgesics; Anemia, Sickle Cell; Child; Humans; Infusions, Intravenous; Ketamine; Pain; Pain Managem

2019
Ketamine: An Update on Cellular and Subcellular Mechanisms with Implications for Clinical Practice.
    Pain physician, 2017, Volume: 20, Issue:2

    Topics: Analgesics; Anesthetics, Dissociative; Humans; Ketamine; Pain; Receptors, N-Methyl-D-Aspartate

2017
Low dose ketamine use in the emergency department, a new direction in pain management.
    The American journal of emergency medicine, 2017, Volume: 35, Issue:6

    Topics: Analgesics; Analgesics, Opioid; Drug Therapy, Combination; Emergency Service, Hospital; Humans; Keta

2017
Low dose ketamine use in the emergency department, a new direction in pain management.
    The American journal of emergency medicine, 2017, Volume: 35, Issue:6

    Topics: Analgesics; Analgesics, Opioid; Drug Therapy, Combination; Emergency Service, Hospital; Humans; Keta

2017
Low dose ketamine use in the emergency department, a new direction in pain management.
    The American journal of emergency medicine, 2017, Volume: 35, Issue:6

    Topics: Analgesics; Analgesics, Opioid; Drug Therapy, Combination; Emergency Service, Hospital; Humans; Keta

2017
Low dose ketamine use in the emergency department, a new direction in pain management.
    The American journal of emergency medicine, 2017, Volume: 35, Issue:6

    Topics: Analgesics; Analgesics, Opioid; Drug Therapy, Combination; Emergency Service, Hospital; Humans; Keta

2017
Low dose ketamine use in the emergency department, a new direction in pain management.
    The American journal of emergency medicine, 2017, Volume: 35, Issue:6

    Topics: Analgesics; Analgesics, Opioid; Drug Therapy, Combination; Emergency Service, Hospital; Humans; Keta

2017
Low dose ketamine use in the emergency department, a new direction in pain management.
    The American journal of emergency medicine, 2017, Volume: 35, Issue:6

    Topics: Analgesics; Analgesics, Opioid; Drug Therapy, Combination; Emergency Service, Hospital; Humans; Keta

2017
Low dose ketamine use in the emergency department, a new direction in pain management.
    The American journal of emergency medicine, 2017, Volume: 35, Issue:6

    Topics: Analgesics; Analgesics, Opioid; Drug Therapy, Combination; Emergency Service, Hospital; Humans; Keta

2017
Low dose ketamine use in the emergency department, a new direction in pain management.
    The American journal of emergency medicine, 2017, Volume: 35, Issue:6

    Topics: Analgesics; Analgesics, Opioid; Drug Therapy, Combination; Emergency Service, Hospital; Humans; Keta

2017
Low dose ketamine use in the emergency department, a new direction in pain management.
    The American journal of emergency medicine, 2017, Volume: 35, Issue:6

    Topics: Analgesics; Analgesics, Opioid; Drug Therapy, Combination; Emergency Service, Hospital; Humans; Keta

2017
Low dose ketamine use in the emergency department, a new direction in pain management.
    The American journal of emergency medicine, 2017, Volume: 35, Issue:6

    Topics: Analgesics; Analgesics, Opioid; Drug Therapy, Combination; Emergency Service, Hospital; Humans; Keta

2017
Low dose ketamine use in the emergency department, a new direction in pain management.
    The American journal of emergency medicine, 2017, Volume: 35, Issue:6

    Topics: Analgesics; Analgesics, Opioid; Drug Therapy, Combination; Emergency Service, Hospital; Humans; Keta

2017
Low dose ketamine use in the emergency department, a new direction in pain management.
    The American journal of emergency medicine, 2017, Volume: 35, Issue:6

    Topics: Analgesics; Analgesics, Opioid; Drug Therapy, Combination; Emergency Service, Hospital; Humans; Keta

2017
Low dose ketamine use in the emergency department, a new direction in pain management.
    The American journal of emergency medicine, 2017, Volume: 35, Issue:6

    Topics: Analgesics; Analgesics, Opioid; Drug Therapy, Combination; Emergency Service, Hospital; Humans; Keta

2017
Low dose ketamine use in the emergency department, a new direction in pain management.
    The American journal of emergency medicine, 2017, Volume: 35, Issue:6

    Topics: Analgesics; Analgesics, Opioid; Drug Therapy, Combination; Emergency Service, Hospital; Humans; Keta

2017
Low dose ketamine use in the emergency department, a new direction in pain management.
    The American journal of emergency medicine, 2017, Volume: 35, Issue:6

    Topics: Analgesics; Analgesics, Opioid; Drug Therapy, Combination; Emergency Service, Hospital; Humans; Keta

2017
Low dose ketamine use in the emergency department, a new direction in pain management.
    The American journal of emergency medicine, 2017, Volume: 35, Issue:6

    Topics: Analgesics; Analgesics, Opioid; Drug Therapy, Combination; Emergency Service, Hospital; Humans; Keta

2017
Efficacy of lidocaine on preventing incidence and severity of pain associated with propofol using in pediatric patients: A PRISMA-compliant meta-analysis of randomized controlled trials.
    Medicine, 2017, Volume: 96, Issue:11

    Topics: Adolescent; Alfentanil; Anesthetics, Intravenous; Anesthetics, Local; Child; Double-Blind Method; Hu

2017
The evolution of pain management in the critically ill trauma patient: Emerging concepts from the global war on terrorism.
    Critical care medicine, 2008, Volume: 36, Issue:7 Suppl

    Topics: Analgesia; Analgesics; Analgesics, Opioid; Anesthesia, Conduction; Anti-Inflammatory Agents, Non-Ste

2008
The evolution of pain management in the critically ill trauma patient: Emerging concepts from the global war on terrorism.
    Critical care medicine, 2008, Volume: 36, Issue:7 Suppl

    Topics: Analgesia; Analgesics; Analgesics, Opioid; Anesthesia, Conduction; Anti-Inflammatory Agents, Non-Ste

2008
The evolution of pain management in the critically ill trauma patient: Emerging concepts from the global war on terrorism.
    Critical care medicine, 2008, Volume: 36, Issue:7 Suppl

    Topics: Analgesia; Analgesics; Analgesics, Opioid; Anesthesia, Conduction; Anti-Inflammatory Agents, Non-Ste

2008
The evolution of pain management in the critically ill trauma patient: Emerging concepts from the global war on terrorism.
    Critical care medicine, 2008, Volume: 36, Issue:7 Suppl

    Topics: Analgesia; Analgesics; Analgesics, Opioid; Anesthesia, Conduction; Anti-Inflammatory Agents, Non-Ste

2008
[Central and peripheral mechanisms in antinociception: current and future perspectives].
    Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology, 2008, Volume: 10, Issue:3

    Topics: Amines; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Bridged Bicyclo Compounds, Heterocycl

2008
Ketamine for chronic non-cancer pain.
    Pain, 2009, Volume: 141, Issue:3

    Topics: Analgesics; Animals; Chronic Disease; Drug Administration Routes; Humans; Ketamine; Pain

2009
Ketamine for chronic non-cancer pain.
    Pain, 2009, Volume: 141, Issue:3

    Topics: Analgesics; Animals; Chronic Disease; Drug Administration Routes; Humans; Ketamine; Pain

2009
Ketamine for chronic non-cancer pain.
    Pain, 2009, Volume: 141, Issue:3

    Topics: Analgesics; Animals; Chronic Disease; Drug Administration Routes; Humans; Ketamine; Pain

2009
Ketamine for chronic non-cancer pain.
    Pain, 2009, Volume: 141, Issue:3

    Topics: Analgesics; Animals; Chronic Disease; Drug Administration Routes; Humans; Ketamine; Pain

2009
Intravenous infusion tests have limited utility for selecting long-term drug therapy in patients with chronic pain: a systematic review.
    Anesthesiology, 2009, Volume: 111, Issue:2

    Topics: Adrenergic alpha-Antagonists; Analgesics, Opioid; Anesthetics, Dissociative; Anesthetics, Local; Chr

2009
Use of oral ketamine in chronic pain management: a review.
    European journal of pain (London, England), 2010, Volume: 14, Issue:5

    Topics: Administration, Oral; Analgesics; Chronic Disease; Humans; Ketamine; Pain

2010
[Treatment of acute pain during drug-assisted rehabilitation].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2010, Apr-08, Volume: 130, Issue:7

    Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents

2010
Pain management in the paediatric population: the regulatory situation in Europe.
    Archives of disease in childhood, 2010, Volume: 95, Issue:9

    Topics: Adolescent; Analgesics; Buprenorphine; Child; Child, Preschool; Clonidine; Drug and Narcotic Control

2010
Ketamine for the treatment of chronic non-cancer pain.
    Expert opinion on pharmacotherapy, 2010, Volume: 11, Issue:14

    Topics: Analgesics; Chronic Disease; Humans; Infusions, Intravenous; Ketamine; Pain; Pain Measurement; Recep

2010
NMDA receptor antagonists and pain: ketamine.
    The Veterinary clinics of North America. Equine practice, 2010, Volume: 26, Issue:3

    Topics: Animals; Excitatory Amino Acid Antagonists; Horse Diseases; Horses; Ketamine; Pain; Receptors, N-Met

2010
[Pain management of burn injuries].
    Der Anaesthesist, 2011, Volume: 60, Issue:3

    Topics: Analgesics; Analgesics, Opioid; Anesthesia, Conduction; Anesthetics, Dissociative; Anti-Inflammatory

2011
Pharmacotherapy for acute pain in children: current practice and recent advances.
    Expert opinion on pharmacotherapy, 2011, Volume: 12, Issue:6

    Topics: Acetaminophen; Acute Disease; Adolescent; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents,

2011
Recreational ketamine: from pleasure to pain.
    BJU international, 2011, Volume: 107, Issue:12

    Topics: Adolescent; Adult; Analgesics; Epidemiologic Methods; Humans; Illicit Drugs; Ketamine; Middle Aged;

2011
Ketamine*.
    Journal of pain and symptom management, 2011, Volume: 41, Issue:3

    Topics: Anesthesia; Anesthetics, Dissociative; Animals; Excitatory Amino Acid Antagonists; Humans; Ketamine;

2011
Ketamine in pain management.
    Advances in psychosomatic medicine, 2011, Volume: 30

    Topics: Analgesics; Analgesics, Opioid; Chronic Disease; Drug Therapy, Combination; Humans; Ketamine; Pain

2011
Ketamine as an analgesic in the pre-hospital setting: a systematic review.
    Acta anaesthesiologica Scandinavica, 2011, Volume: 55, Issue:6

    Topics: Analgesics; Emergency Medical Services; Humans; Ketamine; Pain; Randomized Controlled Trials as Topi

2011
Ketamine as an analgesic in the pre-hospital setting: a systematic review.
    Acta anaesthesiologica Scandinavica, 2011, Volume: 55, Issue:6

    Topics: Analgesics; Emergency Medical Services; Humans; Ketamine; Pain; Randomized Controlled Trials as Topi

2011
Ketamine as an analgesic in the pre-hospital setting: a systematic review.
    Acta anaesthesiologica Scandinavica, 2011, Volume: 55, Issue:6

    Topics: Analgesics; Emergency Medical Services; Humans; Ketamine; Pain; Randomized Controlled Trials as Topi

2011
Ketamine as an analgesic in the pre-hospital setting: a systematic review.
    Acta anaesthesiologica Scandinavica, 2011, Volume: 55, Issue:6

    Topics: Analgesics; Emergency Medical Services; Humans; Ketamine; Pain; Randomized Controlled Trials as Topi

2011
Oral ketamine in the palliative care setting: a review of the literature and case report of a patient with neurofibromatosis type 1 and glomus tumor-associated complex regional pain syndrome.
    The American journal of hospice & palliative care, 2012, Volume: 29, Issue:4

    Topics: Administration, Oral; Adult; Analgesics; Complex Regional Pain Syndromes; Female; Glomus Tumor; Huma

2012
A systematic review of ketamine as an analgesic agent in adult burn injuries.
    Pain medicine (Malden, Mass.), 2011, Volume: 12, Issue:10

    Topics: Analgesics, Opioid; Anesthetics, Dissociative; Burns; Databases, Factual; Humans; Ketamine; Pain; Pa

2011
Ketamine for treatment-resistant unipolar depression: current evidence.
    CNS drugs, 2012, Mar-01, Volume: 26, Issue:3

    Topics: Antidepressive Agents; Cognition; Depressive Disorder; Depressive Disorder, Treatment-Resistant; Dru

2012
[Sedation and analgesia in emergency structure. Paediatry: Which sedation and analgesia for the child under spontaneous ventilation?].
    Annales francaises d'anesthesie et de reanimation, 2012, Volume: 31, Issue:4

    Topics: Analgesia; Analgesics; Analgesics, Opioid; Anesthesia, Conduction; Anesthesia, Local; Anesthetics, D

2012
Ketamine for pain: an update of uses in palliative care.
    Journal of palliative medicine, 2012, Volume: 15, Issue:4

    Topics: Anesthetics, Dissociative; Humans; Ischemia; Ketamine; Neoplasms; Neuralgia; Pain; Palliative Care;

2012
Ketamine as an adjuvant to opioids for cancer pain.
    The Cochrane database of systematic reviews, 2012, Nov-14, Volume: 11

    Topics: Adult; Analgesics; Chemotherapy, Adjuvant; Drug Therapy, Combination; Hallucinations; Humans; Ketami

2012
Ketamine, propofol, and ketofol use for pediatric sedation.
    Pediatric emergency care, 2012, Volume: 28, Issue:12

    Topics: Adolescent; Amnesia; Analgesia; Analgesics, Non-Narcotic; Anesthetics, Dissociative; Antiemetics; An

2012
Adjuvant ketamine analgesia for the management of cancer pain.
    The Annals of pharmacotherapy, 2002, Volume: 36, Issue:10

    Topics: Adult; Analgesics; Germinoma; Humans; Injections, Intravenous; Ketamine; Male; Neoplasms; Pain; Test

2002
Intrathecal therapy for chronic pain.
    Stereotactic and functional neurosurgery, 2001, Volume: 77, Issue:1-4

    Topics: Administration, Oral; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Chronic Disease; Hum

2001
Analgesia in critical care.
    The Veterinary clinics of North America. Small animal practice, 2002, Volume: 32, Issue:5

    Topics: Analgesics; Anesthetics, Local; Animals; Anti-Inflammatory Agents, Non-Steroidal; Critical Care; Ket

2002
Ketamine as an adjuvant to opioids for cancer pain.
    The Cochrane database of systematic reviews, 2003, Issue:1

    Topics: Adult; Analgesics; Chemotherapy, Adjuvant; Hallucinations; Humans; Ketamine; Morphine; Neoplasms; Pa

2003
Ketamine as adjuvant to opioids for cancer pain. A qualitative systematic review.
    Journal of pain and symptom management, 2003, Volume: 26, Issue:3

    Topics: Analgesics; Drug Therapy, Combination; Humans; Ketamine; Narcotics; Neoplasms; Pain; Palliative Care

2003
[Palliative care for colon cancer patients as total pain management].
    Nihon rinsho. Japanese journal of clinical medicine, 2003, Volume: 61 Suppl 7

    Topics: Analgesia, Epidural; Anticonvulsants; Antidepressive Agents; Colonic Neoplasms; Drug Therapy, Combin

2003
Ketamine in chronic pain management: an evidence-based review.
    Anesthesia and analgesia, 2003, Volume: 97, Issue:6

    Topics: Chronic Disease; Evidence-Based Medicine; Excitatory Amino Acid Antagonists; Humans; Ketamine; Pain

2003
Ketamine in chronic pain management: an evidence-based review.
    Anesthesia and analgesia, 2003, Volume: 97, Issue:6

    Topics: Chronic Disease; Evidence-Based Medicine; Excitatory Amino Acid Antagonists; Humans; Ketamine; Pain

2003
Ketamine in chronic pain management: an evidence-based review.
    Anesthesia and analgesia, 2003, Volume: 97, Issue:6

    Topics: Chronic Disease; Evidence-Based Medicine; Excitatory Amino Acid Antagonists; Humans; Ketamine; Pain

2003
Ketamine in chronic pain management: an evidence-based review.
    Anesthesia and analgesia, 2003, Volume: 97, Issue:6

    Topics: Chronic Disease; Evidence-Based Medicine; Excitatory Amino Acid Antagonists; Humans; Ketamine; Pain

2003
Morphine is not the only analgesic in palliative care: literature review.
    Journal of advanced nursing, 2004, Volume: 45, Issue:5

    Topics: Analgesics; Analgesics, Opioid; Fentanyl; Humans; Ketamine; Methadone; Morphine; Neoplasms; Pain; Pa

2004
A qualitative systematic review of the role of N-methyl-D-aspartate receptor antagonists in preventive analgesia.
    Anesthesia and analgesia, 2004, Volume: 98, Issue:5

    Topics: Analgesics, Opioid; Anesthetics, Dissociative; Clinical Trials as Topic; Dextromethorphan; Excitator

2004
Is intranasal ketamine an appropriate treatment for chronic non-cancer breakthrough pain?
    Pain, 2004, Volume: 108, Issue:1-2

    Topics: Administration, Intranasal; Analgesics; Chronic Disease; Humans; Ketamine; Pain

2004
Ketamine as adjuvant analgesic to opioids: a quantitative and qualitative systematic review.
    Anesthesia and analgesia, 2004, Volume: 99, Issue:2

    Topics: Adult; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, Dissocia

2004
Ketamine as adjuvant analgesic to opioids: a quantitative and qualitative systematic review.
    Anesthesia and analgesia, 2004, Volume: 99, Issue:2

    Topics: Adult; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, Dissocia

2004
Ketamine as adjuvant analgesic to opioids: a quantitative and qualitative systematic review.
    Anesthesia and analgesia, 2004, Volume: 99, Issue:2

    Topics: Adult; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, Dissocia

2004
Ketamine as adjuvant analgesic to opioids: a quantitative and qualitative systematic review.
    Anesthesia and analgesia, 2004, Volume: 99, Issue:2

    Topics: Adult; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, Dissocia

2004
Ketamine as adjuvant analgesic to opioids: a quantitative and qualitative systematic review.
    Anesthesia and analgesia, 2004, Volume: 99, Issue:2

    Topics: Adult; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, Dissocia

2004
Ketamine as adjuvant analgesic to opioids: a quantitative and qualitative systematic review.
    Anesthesia and analgesia, 2004, Volume: 99, Issue:2

    Topics: Adult; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, Dissocia

2004
Ketamine as adjuvant analgesic to opioids: a quantitative and qualitative systematic review.
    Anesthesia and analgesia, 2004, Volume: 99, Issue:2

    Topics: Adult; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, Dissocia

2004
Ketamine as adjuvant analgesic to opioids: a quantitative and qualitative systematic review.
    Anesthesia and analgesia, 2004, Volume: 99, Issue:2

    Topics: Adult; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, Dissocia

2004
Ketamine as adjuvant analgesic to opioids: a quantitative and qualitative systematic review.
    Anesthesia and analgesia, 2004, Volume: 99, Issue:2

    Topics: Adult; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, Dissocia

2004
Ketamine as adjuvant analgesic to opioids: a quantitative and qualitative systematic review.
    Anesthesia and analgesia, 2004, Volume: 99, Issue:2

    Topics: Adult; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, Dissocia

2004
Ketamine as adjuvant analgesic to opioids: a quantitative and qualitative systematic review.
    Anesthesia and analgesia, 2004, Volume: 99, Issue:2

    Topics: Adult; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, Dissocia

2004
Ketamine as adjuvant analgesic to opioids: a quantitative and qualitative systematic review.
    Anesthesia and analgesia, 2004, Volume: 99, Issue:2

    Topics: Adult; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, Dissocia

2004
Ketamine as adjuvant analgesic to opioids: a quantitative and qualitative systematic review.
    Anesthesia and analgesia, 2004, Volume: 99, Issue:2

    Topics: Adult; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, Dissocia

2004
Ketamine as adjuvant analgesic to opioids: a quantitative and qualitative systematic review.
    Anesthesia and analgesia, 2004, Volume: 99, Issue:2

    Topics: Adult; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, Dissocia

2004
Ketamine as adjuvant analgesic to opioids: a quantitative and qualitative systematic review.
    Anesthesia and analgesia, 2004, Volume: 99, Issue:2

    Topics: Adult; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, Dissocia

2004
Ketamine as adjuvant analgesic to opioids: a quantitative and qualitative systematic review.
    Anesthesia and analgesia, 2004, Volume: 99, Issue:2

    Topics: Adult; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, Dissocia

2004
Should ketamine be used as a regular analgesic for patients with chronic pain?
    Hospital medicine (London, England : 1998), 2004, Volume: 65, Issue:7

    Topics: Analgesics; Chronic Disease; Humans; Ketamine; Pain

2004
Ketamine for perioperative pain management.
    Anesthesiology, 2005, Volume: 102, Issue:1

    Topics: Analgesia; Anesthesia, Conduction; Anesthesia, General; Anesthetics, Dissociative; Humans; Ketamine;

2005
Ketamine for perioperative pain management.
    Anesthesiology, 2005, Volume: 102, Issue:1

    Topics: Analgesia; Anesthesia, Conduction; Anesthesia, General; Anesthetics, Dissociative; Humans; Ketamine;

2005
Ketamine for perioperative pain management.
    Anesthesiology, 2005, Volume: 102, Issue:1

    Topics: Analgesia; Anesthesia, Conduction; Anesthesia, General; Anesthetics, Dissociative; Humans; Ketamine;

2005
Ketamine for perioperative pain management.
    Anesthesiology, 2005, Volume: 102, Issue:1

    Topics: Analgesia; Anesthesia, Conduction; Anesthesia, General; Anesthetics, Dissociative; Humans; Ketamine;

2005
Parenteral ketamine as an analgesic adjuvant for severe pain: development and retrospective audit of a protocol for a palliative care unit.
    Journal of palliative medicine, 2005, Volume: 8, Issue:1

    Topics: Adult; Aged; Analgesics; Dose-Response Relationship, Drug; Female; Humans; Infusions, Parenteral; Ke

2005
Pain control: ketamine: low doses may provide relief for some painful conditions.
    The American journal of nursing, 2005, Volume: 105, Issue:4

    Topics: Analgesics; Chronic Disease; Drug Monitoring; Humans; Ketamine; Neoplasms; Pain

2005
Pain management in the wilderness and operational setting.
    Emergency medicine clinics of North America, 2005, Volume: 23, Issue:2

    Topics: Analgesia; Analgesics; Analgesics, Opioid; Anesthesia, Conduction; Anti-Inflammatory Agents, Non-Ste

2005
Metabolic and endocrine effects of sedative agents.
    Current opinion in critical care, 2005, Volume: 11, Issue:4

    Topics: Adrenergic alpha-Agonists; Analgesics; Analgesics, Opioid; Benzodiazepines; Catecholamines; Combined

2005
Pharmacologic management of cancer pain.
    The Journal of the American Osteopathic Association, 2005, Volume: 105, Issue:11 Suppl 5

    Topics: Adrenal Cortex Hormones; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthetics, Loca

2005
Prevention of central sensitization and pain by N-methyl-D-aspartate receptor antagonists.
    Journal of the American Veterinary Medical Association, 2006, Jan-01, Volume: 228, Issue:1

    Topics: Analgesics; Animals; Excitatory Amino Acid Antagonists; Ketamine; Pain; Receptors, N-Methyl-D-Aspart

2006
The potential role of ketamine in hospice analgesia: a literature review.
    The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists, 2006, Volume: 21, Issue:1

    Topics: Analgesics; Clinical Trials as Topic; Drug Therapy, Combination; Hospices; Humans; Ketamine; Narcoti

2006
The role of ketamine in pain management.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2006, Volume: 60, Issue:7

    Topics: Analgesics; Chronic Disease; Humans; Ketamine; Neoplasms; Pain

2006
The role of ketamine in pain management.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2006, Volume: 60, Issue:7

    Topics: Analgesics; Chronic Disease; Humans; Ketamine; Neoplasms; Pain

2006
The role of ketamine in pain management.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2006, Volume: 60, Issue:7

    Topics: Analgesics; Chronic Disease; Humans; Ketamine; Neoplasms; Pain

2006
The role of ketamine in pain management.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2006, Volume: 60, Issue:7

    Topics: Analgesics; Chronic Disease; Humans; Ketamine; Neoplasms; Pain

2006
Symptomatic management of calciphylaxis: a case series and review of the literature.
    Journal of pain and symptom management, 2006, Volume: 32, Issue:2

    Topics: Aged; Analgesics; Analgesics, Opioid; Benzodiazepines; Calciphylaxis; Female; Humans; Hyperesthesia;

2006
Low-dose ketamine in addition to propofol for procedural sedation and analgesia in the emergency department.
    The Annals of pharmacotherapy, 2007, Volume: 41, Issue:3

    Topics: Analgesics; Anesthetics, Dissociative; Conscious Sedation; Drug Therapy, Combination; Emergency Serv

2007
Pharmacological approaches to the management of pain in the neonatal intensive care unit.
    Journal of perinatology : official journal of the California Perinatal Association, 2007, Volume: 27 Suppl 1

    Topics: Analgesics; Analgesics, Opioid; Female; Humans; Infant, Newborn; Infant, Premature; Intensive Care U

2007
Low dose ketamine: a therapeutic and research tool to explore N-methyl-D-aspartate (NMDA) receptor-mediated plasticity in pain pathways.
    Journal of psychopharmacology (Oxford, England), 2007, Volume: 21, Issue:3

    Topics: Animals; Excitatory Amino Acid Antagonists; Humans; Ketamine; Neuronal Plasticity; Pain; Receptors,

2007
Ketamine: a controversial drug for neonates.
    Seminars in perinatology, 2007, Volume: 31, Issue:5

    Topics: Anesthetics, Dissociative; Clinical Trials as Topic; Humans; Infant; Infant, Newborn; Ketamine; Pain

2007
Recent advances in the pharmacological management of pain.
    Drugs, 2007, Volume: 67, Issue:15

    Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthetics, Local; Animals

2007
The management of pain in children with life-limiting illnesses.
    Pediatric clinics of North America, 2007, Volume: 54, Issue:5

    Topics: Analgesics, Opioid; Child; Chronic Disease; Codeine; Fentanyl; Humans; Hydromorphone; Ketamine; Meth

2007
Combination ketamine and propofol for procedural sedation and analgesia.
    Pharmacotherapy, 2007, Volume: 27, Issue:11

    Topics: Analgesics; Anesthetics, Dissociative; Conscious Sedation; Controlled Clinical Trials as Topic; Drug

2007
Ketamine.
    Handbook of experimental pharmacology, 2008, Issue:182

    Topics: Analgesics; Anesthetics, Dissociative; Animals; Central Nervous System; Contraindications; Dose-Resp

2008
The use of ketamine as adjuvant therapy to control severe pain.
    Clinical journal of oncology nursing, 2008, Volume: 12, Issue:1

    Topics: Adult; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Drug Monitoring; Drug Therapy,

2008
Systemic analgesia during labor.
    Clinics in perinatology, 1982, Volume: 9, Issue:1

    Topics: Acid-Base Equilibrium; Analgesics; Animals; Child Behavior; Diazepam; Female; Fentanyl; Fetal Heart;

1982
Spinal antinociception: clinical aspects.
    Annals of medicine, 1995, Volume: 27, Issue:2

    Topics: Adrenergic alpha-Agonists; Analgesia, Epidural; Analgesics; Clinical Trials as Topic; Clonidine; Dru

1995
Clinical applications of excitatory amino acid antagonists in pain management.
    Acta anaesthesiologica Sinica, 1995, Volume: 33, Issue:4

    Topics: Analgesia; Excitatory Amino Acid Antagonists; Excitatory Amino Acids; Humans; Ketamine; Pain; Recept

1995
Ketamine in cancer pain: an update.
    Palliative medicine, 1996, Volume: 10, Issue:3

    Topics: Analgesics, Opioid; Biological Availability; Drug Synergism; Drug Tolerance; Excitatory Amino Acid A

1996
[Treatment of pain in oncology].
    Tumori, 1997, Volume: 83, Issue:2 Suppl

    Topics: Administration, Cutaneous; Analgesics, Opioid; Anesthetics, Dissociative; Diphosphonates; Fentanyl;

1997
Combined opioid-NMDA antagonist therapies. What advantages do they offer for the control of pain syndromes?
    Drugs, 1998, Volume: 55, Issue:1

    Topics: Analgesics, Opioid; Clinical Trials as Topic; Drug Synergism; Drug Therapy, Combination; Drug Tolera

1998
Intravenous analgesia.
    Critical care clinics, 1999, Volume: 15, Issue:1

    Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthetics, Dissociative; Critical Care; Humans; Inje

1999
NMDA-receptor antagonists in neuropathic pain: experimental methods to clinical trials.
    Journal of pain and symptom management, 2000, Volume: 19, Issue:1 Suppl

    Topics: Analgesics; Clinical Trials as Topic; Dextromethorphan; Excitatory Amino Acid Antagonists; Humans; K

2000
Advances in cancer pain management.
    Current oncology reports, 2000, Volume: 2, Issue:4

    Topics: Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Bone Diseases; Bone Neoplasms; Chemothe

2000
Management of acute pain and anxiety in children undergoing procedures in the emergency department.
    Pediatric emergency care, 2001, Volume: 17, Issue:2

    Topics: Acute Disease; Analgesia; Analgesics; Anesthesia, Local; Anxiety; Child; Child, Hospitalized; Emerge

2001
The role of nicotinic acetylcholine receptors in the mechanisms of anesthesia.
    Brain research bulletin, 2002, Jan-15, Volume: 57, Issue:2

    Topics: Acetylcholine; Analgesics; Anesthesia; Anesthetics; Anesthetics, Inhalation; Animals; Binding, Compe

2002
Current views on the role of opioid receptors and endorphins in anesthesiology.
    International anesthesiology clinics, 1986,Summer, Volume: 24, Issue:2

    Topics: Acute Disease; Anesthesia; Animals; Blood Circulation; Chronic Disease; Endorphins; Halothane; Human

1986

Trials

134 trials available for ketamine and Ache

ArticleYear
Plasma inflammatory cytokines and treatment-resistant depression with comorbid pain: improvement by ketamine.
    Journal of neuroinflammation, 2021, Sep-15, Volume: 18, Issue:1

    Topics: Case-Control Studies; Cytokines; Depression; Depressive Disorder, Treatment-Resistant; Humans; Ketam

2021
'NOPAIN-ROP' trial: Intravenous fentanyl and intravenous ketamine for pain relief during laser photocoagulation for retinopathy of prematurity (ROP) in preterm infants: A randomised trial.
    BMJ open, 2021, 09-16, Volume: 11, Issue:9

    Topics: Fentanyl; Humans; Infant; Infant, Newborn; Infant, Premature; Ketamine; Lasers; Light Coagulation; P

2021
Comparing the Efficacy and Safety of Dexmedetomidine/Ketamine with Propofol/Fentanyl for Sedation in Colonoscopy Patients: A Doubleblinded Randomized Clinical Trial.
    CNS & neurological disorders drug targets, 2022, Volume: 21, Issue:8

    Topics: Apnea; Colonoscopy; Dexmedetomidine; Double-Blind Method; Fentanyl; Humans; Hypnotics and Sedatives;

2022
Ketamine Compared With Fentanyl for Surgical Abortion: A Randomized Controlled Trial.
    Obstetrics and gynecology, 2022, 09-01, Volume: 140, Issue:3

    Topics: Double-Blind Method; Female; Fentanyl; Humans; Ketamine; Midazolam; Pain; Pregnancy

2022
Pretreatment with Low-Dose Esketamine for Reduction of Propofol Injection Pain: A Randomized Controlled Trial.
    Pain research & management, 2022, Volume: 2022

    Topics: Anesthetics, Intravenous; Double-Blind Method; Humans; Ketamine; Lidocaine; Pain; Propofol

2022
Comparison of Propofol-Fentanyl with Midazolam-Ketamine Combination in Pediatric Patients Undergoing Kidney Biopsy.
    Iranian journal of kidney diseases, 2022, Volume: 16, Issue:4

    Topics: Analgesics; Biopsy; Child; Fentanyl; Humans; Ketamine; Kidney; Midazolam; Pain; Propofol

2022
The efficacy and safety of midazolam with fentanyl versus midazolam with ketamine for bedside invasive procedural sedation in pediatric oncology patients: A randomized, double-blinded, crossover trial.
    Pediatric hematology and oncology, 2022, Volume: 39, Issue:8

    Topics: Child; Cross-Over Studies; Fentanyl; Humans; Hypnotics and Sedatives; Ketamine; Midazolam; Neoplasms

2022
Ketamine and dexmedetomidine (Keto-dex) or ketamine and propofol (Keto-fol) for procedural sedation during endoscopic retrograde cholangiopancreatography: Which is safer? A randomized clinical trial.
    Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology, 2022, Volume: 41, Issue:6

    Topics: Adolescent; Adult; Aged; Cholangiopancreatography, Endoscopic Retrograde; Conscious Sedation; Dexmed

2022
Comparing the Effects of Low-Dose Ketamine, Fentanyl, and Morphine on Hemorrhagic Tolerance and Analgesia in Humans.
    Prehospital emergency care, 2023, Volume: 27, Issue:5

    Topics: Adult; Analgesia; Analgesics; Analgesics, Opioid; Cross-Over Studies; Emergency Medical Services; Fe

2023
Efficacy of ketamine mouthwash in the management of oral and pharyngeal toxicity associated with head and neck chemoradiotherapy: protocol for a phase II, Simon's two-stage trial.
    BMJ open, 2023, 04-11, Volume: 13, Issue:4

    Topics: Analgesics, Opioid; Chemoradiotherapy; Clinical Trials, Phase II as Topic; Head and Neck Neoplasms;

2023
Brain connectivity under light sedation with midazolam and ketamine during task performance and the periodic experience of pain: Examining concordance between different approaches for seed-based connectivity analysis.
    Brain imaging and behavior, 2023, Volume: 17, Issue:5

    Topics: Adult; Brain; Humans; Ketamine; Magnetic Resonance Imaging; Midazolam; Pain; Task Performance and An

2023
Midazolam and Ketamine Produce Distinct Neural Changes in Memory, Pain, and Fear Networks during Pain.
    Anesthesiology, 2021, 07-01, Volume: 135, Issue:1

    Topics: Adolescent; Adult; Analgesics; Anesthetics, Intravenous; Brain; Cross-Over Studies; Fear; Female; Hu

2021
Single bolus low-dose of ketamine does not prevent postpartum depression: a randomized, double-blind, placebo-controlled, prospective clinical trial.
    Archives of gynecology and obstetrics, 2017, Volume: 295, Issue:5

    Topics: Adult; Cesarean Section; Depression, Postpartum; Double-Blind Method; Female; Humans; Ketamine; Pain

2017
Subdissociative intranasal ketamine plus standard pain therapy versus standard pain therapy in the treatment of paediatric sickle cell disease vaso-occlusive crises in resource-limited settings: study protocol for a randomised controlled trial.
    BMJ open, 2017, Jul-10, Volume: 7, Issue:7

    Topics: Administration, Intranasal; Adolescent; Analgesics; Anemia, Sickle Cell; Cameroon; Child; Child, Pre

2017
Slow Infusion of Low-dose Ketamine Reduces Bothersome Side Effects Compared to Intravenous Push: A Double-blind, Double-dummy, Randomized Controlled Trial.
    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2018, Volume: 25, Issue:9

    Topics: Adult; Analgesics; Double-Blind Method; Female; Humans; Infusions, Intravenous; Injections, Intraven

2018
Slow Infusion of Low-dose Ketamine Reduces Bothersome Side Effects Compared to Intravenous Push: A Double-blind, Double-dummy, Randomized Controlled Trial.
    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2018, Volume: 25, Issue:9

    Topics: Adult; Analgesics; Double-Blind Method; Female; Humans; Infusions, Intravenous; Injections, Intraven

2018
Slow Infusion of Low-dose Ketamine Reduces Bothersome Side Effects Compared to Intravenous Push: A Double-blind, Double-dummy, Randomized Controlled Trial.
    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2018, Volume: 25, Issue:9

    Topics: Adult; Analgesics; Double-Blind Method; Female; Humans; Infusions, Intravenous; Injections, Intraven

2018
Slow Infusion of Low-dose Ketamine Reduces Bothersome Side Effects Compared to Intravenous Push: A Double-blind, Double-dummy, Randomized Controlled Trial.
    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2018, Volume: 25, Issue:9

    Topics: Adult; Analgesics; Double-Blind Method; Female; Humans; Infusions, Intravenous; Injections, Intraven

2018
Slow Infusion of Low-dose Ketamine Reduces Bothersome Side Effects Compared to Intravenous Push: A Double-blind, Double-dummy, Randomized Controlled Trial.
    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2018, Volume: 25, Issue:9

    Topics: Adult; Analgesics; Double-Blind Method; Female; Humans; Infusions, Intravenous; Injections, Intraven

2018
Slow Infusion of Low-dose Ketamine Reduces Bothersome Side Effects Compared to Intravenous Push: A Double-blind, Double-dummy, Randomized Controlled Trial.
    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2018, Volume: 25, Issue:9

    Topics: Adult; Analgesics; Double-Blind Method; Female; Humans; Infusions, Intravenous; Injections, Intraven

2018
Slow Infusion of Low-dose Ketamine Reduces Bothersome Side Effects Compared to Intravenous Push: A Double-blind, Double-dummy, Randomized Controlled Trial.
    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2018, Volume: 25, Issue:9

    Topics: Adult; Analgesics; Double-Blind Method; Female; Humans; Infusions, Intravenous; Injections, Intraven

2018
Slow Infusion of Low-dose Ketamine Reduces Bothersome Side Effects Compared to Intravenous Push: A Double-blind, Double-dummy, Randomized Controlled Trial.
    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2018, Volume: 25, Issue:9

    Topics: Adult; Analgesics; Double-Blind Method; Female; Humans; Infusions, Intravenous; Injections, Intraven

2018
Slow Infusion of Low-dose Ketamine Reduces Bothersome Side Effects Compared to Intravenous Push: A Double-blind, Double-dummy, Randomized Controlled Trial.
    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2018, Volume: 25, Issue:9

    Topics: Adult; Analgesics; Double-Blind Method; Female; Humans; Infusions, Intravenous; Injections, Intraven

2018
Analgesic Efficacy of Intranasal Ketamine Versus Intranasal Fentanyl for Moderate to Severe Pain in Children: A Prospective, Randomized, Double-Blind Study.
    Pediatric emergency care, 2021, May-01, Volume: 37, Issue:5

    Topics: Administration, Intranasal; Adolescent; Analgesics; Child; Child, Preschool; Double-Blind Method; Fe

2021
Effect of Intranasal Ketamine vs Fentanyl on Pain Reduction for Extremity Injuries in Children: The PRIME Randomized Clinical Trial.
    JAMA pediatrics, 2019, 02-01, Volume: 173, Issue:2

    Topics: Administration, Intranasal; Adolescent; Analgesics; Analgesics, Opioid; Child; Double-Blind Method;

2019
Sub-dissociative dose intranasal ketamine for limb injury pain in children in the emergency department: a pilot study.
    Emergency medicine Australasia : EMA, 2013, Volume: 25, Issue:2

    Topics: Administration, Intranasal; Adolescent; Analgesics; Australia; Child; Child, Preschool; Dose-Respons

2013
Sub-dissociative dose intranasal ketamine for limb injury pain in children in the emergency department: a pilot study.
    Emergency medicine Australasia : EMA, 2013, Volume: 25, Issue:2

    Topics: Administration, Intranasal; Adolescent; Analgesics; Australia; Child; Child, Preschool; Dose-Respons

2013
Sub-dissociative dose intranasal ketamine for limb injury pain in children in the emergency department: a pilot study.
    Emergency medicine Australasia : EMA, 2013, Volume: 25, Issue:2

    Topics: Administration, Intranasal; Adolescent; Analgesics; Australia; Child; Child, Preschool; Dose-Respons

2013
Sub-dissociative dose intranasal ketamine for limb injury pain in children in the emergency department: a pilot study.
    Emergency medicine Australasia : EMA, 2013, Volume: 25, Issue:2

    Topics: Administration, Intranasal; Adolescent; Analgesics; Australia; Child; Child, Preschool; Dose-Respons

2013
Sub-dissociative dose intranasal ketamine for limb injury pain in children in the emergency department: a pilot study.
    Emergency medicine Australasia : EMA, 2013, Volume: 25, Issue:2

    Topics: Administration, Intranasal; Adolescent; Analgesics; Australia; Child; Child, Preschool; Dose-Respons

2013
Sub-dissociative dose intranasal ketamine for limb injury pain in children in the emergency department: a pilot study.
    Emergency medicine Australasia : EMA, 2013, Volume: 25, Issue:2

    Topics: Administration, Intranasal; Adolescent; Analgesics; Australia; Child; Child, Preschool; Dose-Respons

2013
Sub-dissociative dose intranasal ketamine for limb injury pain in children in the emergency department: a pilot study.
    Emergency medicine Australasia : EMA, 2013, Volume: 25, Issue:2

    Topics: Administration, Intranasal; Adolescent; Analgesics; Australia; Child; Child, Preschool; Dose-Respons

2013
Sub-dissociative dose intranasal ketamine for limb injury pain in children in the emergency department: a pilot study.
    Emergency medicine Australasia : EMA, 2013, Volume: 25, Issue:2

    Topics: Administration, Intranasal; Adolescent; Analgesics; Australia; Child; Child, Preschool; Dose-Respons

2013
Sub-dissociative dose intranasal ketamine for limb injury pain in children in the emergency department: a pilot study.
    Emergency medicine Australasia : EMA, 2013, Volume: 25, Issue:2

    Topics: Administration, Intranasal; Adolescent; Analgesics; Australia; Child; Child, Preschool; Dose-Respons

2013
Sub-dissociative dose intranasal ketamine for limb injury pain in children in the emergency department: a pilot study.
    Emergency medicine Australasia : EMA, 2013, Volume: 25, Issue:2

    Topics: Administration, Intranasal; Adolescent; Analgesics; Australia; Child; Child, Preschool; Dose-Respons

2013
Sub-dissociative dose intranasal ketamine for limb injury pain in children in the emergency department: a pilot study.
    Emergency medicine Australasia : EMA, 2013, Volume: 25, Issue:2

    Topics: Administration, Intranasal; Adolescent; Analgesics; Australia; Child; Child, Preschool; Dose-Respons

2013
Sub-dissociative dose intranasal ketamine for limb injury pain in children in the emergency department: a pilot study.
    Emergency medicine Australasia : EMA, 2013, Volume: 25, Issue:2

    Topics: Administration, Intranasal; Adolescent; Analgesics; Australia; Child; Child, Preschool; Dose-Respons

2013
Sub-dissociative dose intranasal ketamine for limb injury pain in children in the emergency department: a pilot study.
    Emergency medicine Australasia : EMA, 2013, Volume: 25, Issue:2

    Topics: Administration, Intranasal; Adolescent; Analgesics; Australia; Child; Child, Preschool; Dose-Respons

2013
Sub-dissociative dose intranasal ketamine for limb injury pain in children in the emergency department: a pilot study.
    Emergency medicine Australasia : EMA, 2013, Volume: 25, Issue:2

    Topics: Administration, Intranasal; Adolescent; Analgesics; Australia; Child; Child, Preschool; Dose-Respons

2013
Sub-dissociative dose intranasal ketamine for limb injury pain in children in the emergency department: a pilot study.
    Emergency medicine Australasia : EMA, 2013, Volume: 25, Issue:2

    Topics: Administration, Intranasal; Adolescent; Analgesics; Australia; Child; Child, Preschool; Dose-Respons

2013
Sub-dissociative dose intranasal ketamine for limb injury pain in children in the emergency department: a pilot study.
    Emergency medicine Australasia : EMA, 2013, Volume: 25, Issue:2

    Topics: Administration, Intranasal; Adolescent; Analgesics; Australia; Child; Child, Preschool; Dose-Respons

2013
A double-blind, randomised, placebo-controlled trial of oral midazolam plus oral ketamine for sedation of children during laceration repair.
    Emergency medicine journal : EMJ, 2014, Volume: 31, Issue:8

    Topics: Administration, Oral; Anesthetics, Dissociative; Child; Child, Preschool; Conscious Sedation; Double

2014
Long-term pain prevalence and health-related quality of life outcomes for patients enrolled in a ketamine versus morphine for prehospital traumatic pain randomised controlled trial.
    Emergency medicine journal : EMJ, 2014, Volume: 31, Issue:10

    Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics; Australia; Emergency Medicine

2014
An effective dose of ketamine for eliminating pain during injection of propofol: a dose response study.
    Annales francaises d'anesthesie et de reanimation, 2013, Volume: 32, Issue:9

    Topics: Adult; Anesthetics, Dissociative; Anesthetics, Intravenous; Dose-Response Relationship, Drug; Double

2013
Efficacy of ketamine hydrochloride administered as a basilar sesamoid nerve block in alleviating foot pain in horses caused by natural disease.
    Equine veterinary journal, 2014, Volume: 46, Issue:5

    Topics: Analgesics; Animals; Foot Diseases; Horse Diseases; Horses; Ketamine; Lameness, Animal; Nerve Block;

2014
Anaesthetic, analgesic and cardiorespiratory effects of intramuscular medetomidine-ketamine combination alone or with morphine or tramadol for orchiectomy in cats.
    Veterinary anaesthesia and analgesia, 2014, Volume: 41, Issue:4

    Topics: Analgesia; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthetics, Combined; Anesthetics, Dissoci

2014
Evaluating the hematoma block as an adjunct to procedural sedation for closed reduction of distal forearm fractures.
    Pediatric emergency care, 2014, Volume: 30, Issue:7

    Topics: Adolescent; Anesthetics, Local; Child; Child, Preschool; Conscious Sedation; Double-Blind Method; Fe

2014
[Periods of post-anesthetic rehabilitation and anesthesia dosage for laparoscopic cholecystectomy: retrospective investigation].
    Eksperimental'naia i klinicheskaia farmakologiia, 2014, Volume: 77, Issue:8

    Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Anesthesia, General; Anesthetics, Intraveno

2014
Propofol-ketamine or propofol-remifentanil for deep sedation and analgesia in pediatric patients undergoing burn dressing changes: a randomized clinical trial.
    Paediatric anaesthesia, 2015, Volume: 25, Issue:6

    Topics: Analgesia; Anesthesia Recovery Period; Anesthetics, Dissociative; Anesthetics, Intravenous; Bandages

2015
The clinical effect of fentanyl in comparison with ketamine in analgesic effect for oncology procedures in children: a randomized, double-blinded, crossover trial.
    Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 2015, Volume: 98, Issue:4

    Topics: Adolescent; Analgesics; Analgesics, Opioid; Child; Child, Preschool; Cross-Over Studies; Double-Blin

2015
Effects of Different Anesthetics on Pain Processing in an Experimental Human Pain Model.
    Pain practice : the official journal of World Institute of Pain, 2016, Volume: 16, Issue:7

    Topics: Adult; Analgesics, Opioid; Anesthetics; Female; Humans; Hyperalgesia; Ketamine; Male; Pain; Pain Mea

2016
Two Different Concentrations of Ketofol for Procedural Sedation and Analgesia in Closed Reduction of Nasal Fracture.
    The Journal of craniofacial surgery, 2016, Volume: 27, Issue:4

    Topics: Adolescent; Adult; Analgesia; Anesthetics, Intravenous; Child; Conscious Sedation; Double-Blind Meth

2016
Study protocol of a randomised controlled trial of intranasal ketamine compared with intranasal fentanyl for analgesia in children with suspected, isolated extremity fractures in the paediatric emergency department.
    BMJ open, 2016, 09-08, Volume: 6, Issue:9

    Topics: Administration, Intranasal; Adolescent; Analgesia; Analgesics; Analgesics, Opioid; Child; Child, Pre

2016
Serum concentration of ketamine and antinociceptive effects of ketamine and ketamine-lidocaine infusions in conscious dogs.
    BMC veterinary research, 2016, Sep-09, Volume: 12, Issue:1

    Topics: Analgesics; Anesthetics, Local; Animals; Cross-Over Studies; Dog Diseases; Dogs; Ketamine; Lidocaine

2016
Intranasal ketamine for acute traumatic pain in the Emergency Department: a prospective, randomized clinical trial of efficacy and safety.
    BMC emergency medicine, 2016, 11-09, Volume: 16, Issue:1

    Topics: Administration, Intranasal; Adolescent; Adult; Aged; Analgesics; Double-Blind Method; Emergency Serv

2016
Treatment of severe mucositis pain with oral ketamine mouthwash.
    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2017, Volume: 25, Issue:7

    Topics: Adult; Aged; Female; Hematopoietic Stem Cell Transplantation; Humans; Ketamine; Male; Middle Aged; M

2017
Ketamine and midazolam delivered by patient-controlled analgesia in relieving pain associated with burns dressings.
    The Clinical journal of pain, 2008, Volume: 24, Issue:7

    Topics: Adolescent; Adult; Aged; Analgesia, Patient-Controlled; Analgesics; Bandages; Burns; Drug Therapy, C

2008
Ketamine and midazolam delivered by patient-controlled analgesia in relieving pain associated with burns dressings.
    The Clinical journal of pain, 2008, Volume: 24, Issue:7

    Topics: Adolescent; Adult; Aged; Analgesia, Patient-Controlled; Analgesics; Bandages; Burns; Drug Therapy, C

2008
Ketamine and midazolam delivered by patient-controlled analgesia in relieving pain associated with burns dressings.
    The Clinical journal of pain, 2008, Volume: 24, Issue:7

    Topics: Adolescent; Adult; Aged; Analgesia, Patient-Controlled; Analgesics; Bandages; Burns; Drug Therapy, C

2008
Ketamine and midazolam delivered by patient-controlled analgesia in relieving pain associated with burns dressings.
    The Clinical journal of pain, 2008, Volume: 24, Issue:7

    Topics: Adolescent; Adult; Aged; Analgesia, Patient-Controlled; Analgesics; Bandages; Burns; Drug Therapy, C

2008
Intravenous ketamine plus midazolam vs. intravenous ketamine for sedation in lumbar puncture: a randomized controlled trial.
    Indian pediatrics, 2008, Volume: 45, Issue:11

    Topics: Adolescent; Anesthetics, Dissociative; Anesthetics, Intravenous; Child; Confidence Intervals; Dizzin

2008
[Efficacy of a low dose of ketamine in reduction of propofol-injection-related pain].
    Annales francaises d'anesthesie et de reanimation, 2009, Volume: 28, Issue:2

    Topics: Adolescent; Adult; Analgesics; Anesthetics, Intravenous; Double-Blind Method; Female; Gynecologic Su

2009
Comparison of ketamine plus midazolam versus ketamine for sedation in children during lumbar puncture.
    The Clinical journal of pain, 2009, Volume: 25, Issue:4

    Topics: Adjuvants, Anesthesia; Adolescent; Analgesics; Child, Preschool; Drug Therapy, Combination; Female;

2009
Effects of low-dose intranasal (S)-ketamine in patients with neuropathic pain.
    European journal of pain (London, England), 2010, Volume: 14, Issue:4

    Topics: Administration, Intranasal; Adult; Aged; Algorithms; Anesthetics, Dissociative; Cardiovascular Syste

2010
Effects of low-dose intranasal (S)-ketamine in patients with neuropathic pain.
    European journal of pain (London, England), 2010, Volume: 14, Issue:4

    Topics: Administration, Intranasal; Adult; Aged; Algorithms; Anesthetics, Dissociative; Cardiovascular Syste

2010
Effects of low-dose intranasal (S)-ketamine in patients with neuropathic pain.
    European journal of pain (London, England), 2010, Volume: 14, Issue:4

    Topics: Administration, Intranasal; Adult; Aged; Algorithms; Anesthetics, Dissociative; Cardiovascular Syste

2010
Effects of low-dose intranasal (S)-ketamine in patients with neuropathic pain.
    European journal of pain (London, England), 2010, Volume: 14, Issue:4

    Topics: Administration, Intranasal; Adult; Aged; Algorithms; Anesthetics, Dissociative; Cardiovascular Syste

2010
Pain relief during dressing changes of major adult burns: ideal analgesic combination with ketamine.
    Burns : journal of the International Society for Burn Injuries, 2010, Volume: 36, Issue:4

    Topics: Adult; Analgesics; Bandages; Blood Pressure; Burns; Dexmedetomidine; Drug Therapy, Combination; Fema

2010
Prevention of propofol injection pain with small-dose ketamine.
    Middle East journal of anaesthesiology, 2009, Volume: 20, Issue:3

    Topics: Adult; Anesthetics, Intravenous; Double-Blind Method; Female; Humans; Ketamine; Male; Pain; Propofol

2009
Ketamine eliminates propofol pain but does not affect hemodynamics during induction with double-lumen tubes.
    Journal of anesthesia, 2010, Volume: 24, Issue:1

    Topics: Aged; Analgesics; Anesthetics, Intravenous; Dose-Response Relationship, Drug; Female; Hemodynamics;

2010
[Effects of intravenous midazolam, fentanyl or ketamine on pain relief during performance of epidural anesthesia].
    Masui. The Japanese journal of anesthesiology, 2009, Volume: 58, Issue:12

    Topics: Aged; Aged, 80 and over; Analgesics, Opioid; Anesthesia, Epidural; Female; Fentanyl; Humans; Hypnoti

2009
Ketamine improves nasogastric tube insertion.
    Emergency medicine journal : EMJ, 2010, Volume: 27, Issue:8

    Topics: Administration, Intranasal; Adult; Double-Blind Method; Emergency Medicine; Female; Gels; Health Car

2010
Population pharmacokinetic-pharmacodynamic modeling of ketamine-induced pain relief of chronic pain.
    European journal of pain (London, England), 2011, Volume: 15, Issue:3

    Topics: Adult; Analgesia; Analgesics; Chronic Disease; Dose-Response Relationship, Drug; Female; Humans; Ket

2011
Propofol versus propofol/ketamine for brief painful procedures in the emergency department: clinical and bispectral index scale comparison.
    Journal of pain & palliative care pharmacotherapy, 2010, Volume: 24, Issue:4

    Topics: Adult; Anesthesia Recovery Period; Anesthetics, Combined; Anesthetics, Dissociative; Anesthetics, In

2010
A subhypnotic dose of ketamine reduces pain associated with injection of propofol and rocuronium.
    European journal of anaesthesiology, 2011, Volume: 28, Issue:3

    Topics: Adolescent; Adult; Analgesics; Androstanols; Anesthetics, Intravenous; Dose-Response Relationship, D

2011
Effect of ketamine on endogenous pain modulation in healthy volunteers.
    Pain, 2011, Volume: 152, Issue:3

    Topics: Adult; Aged; Anesthetics, Dissociative; Area Under Curve; Cross-Over Studies; Drug Administration Sc

2011
Efficacy of small doses of ketamine with morphine to decrease procedural pain responses during open wound care.
    The Clinical journal of pain, 2011, Volume: 27, Issue:7

    Topics: Adult; Aged; Analgesics; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method;

2011
Absence of long-term analgesic effect from a short-term S-ketamine infusion on fibromyalgia pain: a randomized, prospective, double blind, active placebo-controlled trial.
    European journal of pain (London, England), 2011, Volume: 15, Issue:9

    Topics: Analgesia; Analgesics; Double-Blind Method; Excitatory Amino Acid Antagonists; Female; Fibromyalgia;

2011
Absence of long-term analgesic effect from a short-term S-ketamine infusion on fibromyalgia pain: a randomized, prospective, double blind, active placebo-controlled trial.
    European journal of pain (London, England), 2011, Volume: 15, Issue:9

    Topics: Analgesia; Analgesics; Double-Blind Method; Excitatory Amino Acid Antagonists; Female; Fibromyalgia;

2011
Absence of long-term analgesic effect from a short-term S-ketamine infusion on fibromyalgia pain: a randomized, prospective, double blind, active placebo-controlled trial.
    European journal of pain (London, England), 2011, Volume: 15, Issue:9

    Topics: Analgesia; Analgesics; Double-Blind Method; Excitatory Amino Acid Antagonists; Female; Fibromyalgia;

2011
Absence of long-term analgesic effect from a short-term S-ketamine infusion on fibromyalgia pain: a randomized, prospective, double blind, active placebo-controlled trial.
    European journal of pain (London, England), 2011, Volume: 15, Issue:9

    Topics: Analgesia; Analgesics; Double-Blind Method; Excitatory Amino Acid Antagonists; Female; Fibromyalgia;

2011
Midazolam-ketamine combination for moderate sedation in upper GI endoscopy.
    Journal of pediatric gastroenterology and nutrition, 2012, Volume: 54, Issue:3

    Topics: Adjuvants, Anesthesia; Anesthetics, Dissociative; Child; Child, Preschool; Conscious Sedation; Deep

2012
Intravenous ketamine is as effective as midazolam/fentanyl for procedural sedation and analgesia in the emergency department.
    The Medical journal of Malaysia, 2011, Volume: 66, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthetics, Intravenous; Conscious Sedation; Emergency

2011
Effect of ketamine hydrochloride on the analgesic effects of tramadol hydrochloride in horses with signs of chronic laminitis-associated pain.
    American journal of veterinary research, 2012, Volume: 73, Issue:5

    Topics: Administration, Oral; Analgesics; Analgesics, Opioid; Animals; Cross-Over Studies; Female; Foot Dise

2012
Prevention of propofol-induced pain in children: pretreatment with small doses of ketamine.
    Journal of clinical anesthesia, 2012, Volume: 24, Issue:4

    Topics: Analgesics; Anesthetics, Intravenous; Child; Child, Preschool; Dose-Response Relationship, Drug; Dou

2012
Effect of subanesthetic ketamine on intrinsic functional brain connectivity: a placebo-controlled functional magnetic resonance imaging study in healthy male volunteers.
    Anesthesiology, 2012, Volume: 117, Issue:4

    Topics: Adult; Anesthetics, Dissociative; Brain; Data Interpretation, Statistical; Hallucinogens; Hot Temper

2012
Comparison of effects of ephedrine, lidocaine and ketamine with placebo on injection pain, hypotension and bradycardia due to propofol injection: a randomized placebo controlled clinical trial.
    Acta medica Iranica, 2012, Volume: 50, Issue:9

    Topics: Adult; Anesthetics, Intravenous; Bradycardia; Double-Blind Method; Ephedrine; Female; Humans; Hypote

2012
A randomized comparison of nitrous oxide versus intravenous ketamine for laceration repair in children.
    Pediatric emergency care, 2012, Volume: 28, Issue:12

    Topics: Administration, Inhalation; Analgesics, Non-Narcotic; Anesthesia Recovery Period; Anesthesia, Inhala

2012
A prospective, randomized, double-blind study to compare the efficacy of lidocaine + metoclopramide and lidocaine + ketamine combinations in preventing pain on propofol injection.
    Journal of anesthesia, 2013, Volume: 27, Issue:3

    Topics: Adult; Anesthetics, Combined; Anesthetics, Dissociative; Anesthetics, Intravenous; Anesthetics, Loca

2013
The effects of remifentanil, lidocaine, metoclopramide, or ketamine pretreatment on propofol injection pain.
    Middle East journal of anaesthesiology, 2012, Volume: 21, Issue:5

    Topics: Adult; Aged; Analgesics; Double-Blind Method; Female; Humans; Injections, Intravenous; Ketamine; Lid

2012
Effects of low-dose ketamine on neuropathic pain: An electroencephalogram-electrooculogram/behavioral study.
    Psychiatry and clinical neurosciences, 2002, Volume: 56, Issue:4

    Topics: Aged; Anesthetics, Dissociative; Electroencephalography; Female; Hallucinations; Humans; Injections,

2002
Short- and long-term efficacy of oral ketamine in eight chronic-pain patients.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2002, Volume: 49, Issue:8

    Topics: Administration, Oral; Adult; Aged; Analgesics; Chronic Disease; Excitatory Amino Acid Antagonists; F

2002
Cold allodynia and hyperalgesia in neuropathic pain: the effect of N-methyl-D-aspartate (NMDA) receptor antagonist ketamine--a double-blind, cross-over comparison with alfentanil and placebo.
    Pain, 2003, Volume: 101, Issue:3

    Topics: Adult; Aged; Alfentanil; Analgesics, Opioid; Cold Temperature; Cross-Over Studies; Double-Blind Meth

2003
Short-term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal.
    Pain, 2003, Volume: 106, Issue:1-2

    Topics: Adult; Analgesics, Opioid; Cross-Over Studies; Excitatory Amino Acid Antagonists; Hot Temperature; H

2003
Short-term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal.
    Pain, 2003, Volume: 106, Issue:1-2

    Topics: Adult; Analgesics, Opioid; Cross-Over Studies; Excitatory Amino Acid Antagonists; Hot Temperature; H

2003
Short-term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal.
    Pain, 2003, Volume: 106, Issue:1-2

    Topics: Adult; Analgesics, Opioid; Cross-Over Studies; Excitatory Amino Acid Antagonists; Hot Temperature; H

2003
Short-term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal.
    Pain, 2003, Volume: 106, Issue:1-2

    Topics: Adult; Analgesics, Opioid; Cross-Over Studies; Excitatory Amino Acid Antagonists; Hot Temperature; H

2003
Short-term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal.
    Pain, 2003, Volume: 106, Issue:1-2

    Topics: Adult; Analgesics, Opioid; Cross-Over Studies; Excitatory Amino Acid Antagonists; Hot Temperature; H

2003
Short-term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal.
    Pain, 2003, Volume: 106, Issue:1-2

    Topics: Adult; Analgesics, Opioid; Cross-Over Studies; Excitatory Amino Acid Antagonists; Hot Temperature; H

2003
Short-term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal.
    Pain, 2003, Volume: 106, Issue:1-2

    Topics: Adult; Analgesics, Opioid; Cross-Over Studies; Excitatory Amino Acid Antagonists; Hot Temperature; H

2003
Short-term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal.
    Pain, 2003, Volume: 106, Issue:1-2

    Topics: Adult; Analgesics, Opioid; Cross-Over Studies; Excitatory Amino Acid Antagonists; Hot Temperature; H

2003
Short-term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal.
    Pain, 2003, Volume: 106, Issue:1-2

    Topics: Adult; Analgesics, Opioid; Cross-Over Studies; Excitatory Amino Acid Antagonists; Hot Temperature; H

2003
Short-term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal.
    Pain, 2003, Volume: 106, Issue:1-2

    Topics: Adult; Analgesics, Opioid; Cross-Over Studies; Excitatory Amino Acid Antagonists; Hot Temperature; H

2003
Short-term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal.
    Pain, 2003, Volume: 106, Issue:1-2

    Topics: Adult; Analgesics, Opioid; Cross-Over Studies; Excitatory Amino Acid Antagonists; Hot Temperature; H

2003
Short-term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal.
    Pain, 2003, Volume: 106, Issue:1-2

    Topics: Adult; Analgesics, Opioid; Cross-Over Studies; Excitatory Amino Acid Antagonists; Hot Temperature; H

2003
Short-term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal.
    Pain, 2003, Volume: 106, Issue:1-2

    Topics: Adult; Analgesics, Opioid; Cross-Over Studies; Excitatory Amino Acid Antagonists; Hot Temperature; H

2003
Short-term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal.
    Pain, 2003, Volume: 106, Issue:1-2

    Topics: Adult; Analgesics, Opioid; Cross-Over Studies; Excitatory Amino Acid Antagonists; Hot Temperature; H

2003
Short-term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal.
    Pain, 2003, Volume: 106, Issue:1-2

    Topics: Adult; Analgesics, Opioid; Cross-Over Studies; Excitatory Amino Acid Antagonists; Hot Temperature; H

2003
Short-term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal.
    Pain, 2003, Volume: 106, Issue:1-2

    Topics: Adult; Analgesics, Opioid; Cross-Over Studies; Excitatory Amino Acid Antagonists; Hot Temperature; H

2003
Pretreatment with intravenous ketamine reduces propofol injection pain.
    Paediatric anaesthesia, 2003, Volume: 13, Issue:9

    Topics: Adolescent; Analgesics; Anesthetics, Intravenous; Anesthetics, Local; Child; Child, Preschool; Doubl

2003
An investigation to dissociate the analgesic and anesthetic properties of ketamine using functional magnetic resonance imaging.
    Anesthesiology, 2004, Volume: 100, Issue:2

    Topics: Acoustic Stimulation; Adult; Analgesia; Anesthesia; Anesthetics, Dissociative; Brain; Humans; Ketami

2004
The analgesic effect of intravenous ketamine and lidocaine on pain after spinal cord injury.
    Acta anaesthesiologica Scandinavica, 2004, Volume: 48, Issue:4

    Topics: Adult; Analgesics; Analysis of Variance; Anesthetics, Local; Cross-Over Studies; Double-Blind Method

2004
Differential effects of peripheral ketamine and lidocaine on skin flux and hyperalgesia induced by intradermal capsaicin in humans.
    Clinical physiology and functional imaging, 2004, Volume: 24, Issue:2

    Topics: Administration, Cutaneous; Analgesics; Anesthetics, Local; Capsaicin; Cross-Over Studies; Double-Bli

2004
Safety and efficacy of intranasal ketamine for the treatment of breakthrough pain in patients with chronic pain: a randomized, double-blind, placebo-controlled, crossover study.
    Pain, 2004, Volume: 108, Issue:1-2

    Topics: Administration, Intranasal; Adult; Aged; Analgesics; Analgesics, Opioid; Chronic Disease; Cross-Over

2004
Safety and efficacy of intranasal ketamine for the treatment of breakthrough pain in patients with chronic pain: a randomized, double-blind, placebo-controlled, crossover study.
    Pain, 2004, Volume: 108, Issue:1-2

    Topics: Administration, Intranasal; Adult; Aged; Analgesics; Analgesics, Opioid; Chronic Disease; Cross-Over

2004
Safety and efficacy of intranasal ketamine for the treatment of breakthrough pain in patients with chronic pain: a randomized, double-blind, placebo-controlled, crossover study.
    Pain, 2004, Volume: 108, Issue:1-2

    Topics: Administration, Intranasal; Adult; Aged; Analgesics; Analgesics, Opioid; Chronic Disease; Cross-Over

2004
Safety and efficacy of intranasal ketamine for the treatment of breakthrough pain in patients with chronic pain: a randomized, double-blind, placebo-controlled, crossover study.
    Pain, 2004, Volume: 108, Issue:1-2

    Topics: Administration, Intranasal; Adult; Aged; Analgesics; Analgesics, Opioid; Chronic Disease; Cross-Over

2004
The synergistic effect of combined treatment with systemic ketamine and morphine on experimentally induced windup-like pain in humans.
    Anesthesia and analgesia, 2004, Volume: 98, Issue:6

    Topics: Adult; Burns; Cross-Over Studies; Double-Blind Method; Drug Synergism; Drug Therapy, Combination; Fe

2004
Inter- and intraindividual variability in ketamine dosage in repetitive invasive procedures in children with malignancies.
    Pediatric hematology and oncology, 2004, Volume: 21, Issue:2

    Topics: Adolescent; Anesthetics, Dissociative; Biopsy; Bone Marrow Examination; Child; Child, Preschool; Dia

2004
Ketamine does not decrease postoperative pain after remifentanil-based anaesthesia for tonsillectomy in adults.
    Acta anaesthesiologica Scandinavica, 2004, Volume: 48, Issue:6

    Topics: Adult; Analgesics; Analgesics, Opioid; Analysis of Variance; Anesthesia, Intravenous; Anesthetics, I

2004
Conscious sedation: Off-label use of rectal S(+)-ketamine and midazolam for wound dressing changes in paediatric heat injuries.
    European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie, 2004, Volume: 14, Issue:4

    Topics: Adjuvants, Anesthesia; Analgesics; Bandages; Burns; Child; Child, Preschool; Conscious Sedation; Dru

2004
The intravenous ketamine test: a predictive response tool for oral dextromethorphan treatment in neuropathic pain.
    Anesthesia and analgesia, 2004, Volume: 99, Issue:6

    Topics: Administration, Oral; Adult; Anesthetics, Local; Databases, Factual; Dextromethorphan; Excitatory Am

2004
The effect of ketamine and fentanyl in reducing the pain of diazepam injection.
    Middle East journal of anaesthesiology, 2004, Volume: 17, Issue:6

    Topics: Adolescent; Adult; Analgesics; Anesthetics, Intravenous; Diazepam; Double-Blind Method; Fentanyl; Hu

2004
The effects of racemic ketamine on painful stimulation of skin and viscera in human subjects.
    Pain, 2005, Volume: 113, Issue:3

    Topics: Adolescent; Adult; Analgesics; Analysis of Variance; Catheterization; Cross-Over Studies; Dose-Respo

2005
The effects of racemic ketamine on painful stimulation of skin and viscera in human subjects.
    Pain, 2005, Volume: 113, Issue:3

    Topics: Adolescent; Adult; Analgesics; Analysis of Variance; Catheterization; Cross-Over Studies; Dose-Respo

2005
The effects of racemic ketamine on painful stimulation of skin and viscera in human subjects.
    Pain, 2005, Volume: 113, Issue:3

    Topics: Adolescent; Adult; Analgesics; Analysis of Variance; Catheterization; Cross-Over Studies; Dose-Respo

2005
The effects of racemic ketamine on painful stimulation of skin and viscera in human subjects.
    Pain, 2005, Volume: 113, Issue:3

    Topics: Adolescent; Adult; Analgesics; Analysis of Variance; Catheterization; Cross-Over Studies; Dose-Respo

2005
Intravenous ketamine sedation for painful oncology procedures.
    Paediatric anaesthesia, 2005, Volume: 15, Issue:2

    Topics: Adolescent; Analgesics; Anesthetics, Local; Biopsy, Needle; Bone Marrow Examination; Child; Child, P

2005
Comparison of ephedrine and ketamine in prevention of injection pain and hypotension due to propofol induction.
    European journal of anaesthesiology, 2005, Volume: 22, Issue:1

    Topics: Aged; Anesthesia, Intravenous; Anesthetics, Dissociative; Anesthetics, Intravenous; Double-Blind Met

2005
Ketamine pretreatment with venous occlusion attenuates pain on injection with propofol.
    European journal of anaesthesiology, 2005, Volume: 22, Issue:1

    Topics: Adult; Anesthetics, Dissociative; Anesthetics, Intravenous; Arm; Double-Blind Method; Female; Humans

2005
Preadministration of low-dose ketamine reduces tourniquet pain in healthy volunteers.
    Journal of anesthesia, 2005, Volume: 19, Issue:2

    Topics: Adult; Double-Blind Method; Humans; Ketamine; Male; Middle Aged; Pain; Pain Measurement; Receptors,

2005
Topical 2% amitriptyline and 1% ketamine in neuropathic pain syndromes: a randomized, double-blind, placebo-controlled trial.
    Anesthesiology, 2005, Volume: 103, Issue:1

    Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Amitriptyline; Double-Blind Method; Drug Th

2005
Topical 2% amitriptyline and 1% ketamine in neuropathic pain syndromes: a randomized, double-blind, placebo-controlled trial.
    Anesthesiology, 2005, Volume: 103, Issue:1

    Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Amitriptyline; Double-Blind Method; Drug Th

2005
Topical 2% amitriptyline and 1% ketamine in neuropathic pain syndromes: a randomized, double-blind, placebo-controlled trial.
    Anesthesiology, 2005, Volume: 103, Issue:1

    Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Amitriptyline; Double-Blind Method; Drug Th

2005
Topical 2% amitriptyline and 1% ketamine in neuropathic pain syndromes: a randomized, double-blind, placebo-controlled trial.
    Anesthesiology, 2005, Volume: 103, Issue:1

    Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Amitriptyline; Double-Blind Method; Drug Th

2005
Determining the plasma concentration of ketamine that enhances epidural bupivacaine-and-morphine-induced analgesia.
    Anesthesia and analgesia, 2005, Volume: 101, Issue:3

    Topics: Adult; Aged; Analgesics, Opioid; Anesthesia, Epidural; Anesthetics, Dissociative; Anesthetics, Local

2005
Propofol versus midazolam/ketamine for procedural sedation in pediatric oncology.
    Journal of pediatric hematology/oncology, 2005, Volume: 27, Issue:9

    Topics: Adolescent; Anesthetics, Dissociative; Child; Child, Preschool; Conscious Sedation; Humans; Hypnotic

2005
Is atropine needed with ketamine sedation? A prospective, randomised, double blind study.
    Emergency medicine journal : EMJ, 2006, Volume: 23, Issue:3

    Topics: Adjuvants, Anesthesia; Adolescent; Anesthetics, Dissociative; Atropine; Child; Child, Preschool; Dou

2006
Differential effect of ketamine and lidocaine on spontaneous and mechanical evoked pain in patients with nerve injury pain.
    Anesthesiology, 2006, Volume: 104, Issue:3

    Topics: Adult; Aged; Cross-Over Studies; Double-Blind Method; Female; Humans; Ketamine; Lidocaine; Male; Mid

2006
Imaging pain modulation by subanesthetic S-(+)-ketamine.
    Anesthesia and analgesia, 2006, Volume: 103, Issue:3

    Topics: Adult; Analgesics; Brain; Dose-Response Relationship, Drug; Hemodynamics; Humans; Ketamine; Magnetic

2006
A randomized comparison of nitrous oxide plus hematoma block versus ketamine plus midazolam for emergency department forearm fracture reduction in children.
    Pediatrics, 2006, Volume: 118, Issue:4

    Topics: Adolescent; Analgesics; Analgesics, Non-Narcotic; Anesthetics, Local; Anti-Anxiety Agents; Child; Ch

2006
Differential effect of intravenous S-ketamine and fentanyl on atypical odontalgia and capsaicin-evoked pain.
    Pain, 2007, Volume: 129, Issue:1-2

    Topics: Adult; Analgesics; Analysis of Variance; Area Under Curve; Capsaicin; Case-Control Studies; Double-B

2007
Small-dose ketamine reduces the pain of propofol injection.
    Anesthesia and analgesia, 2006, Volume: 103, Issue:6

    Topics: Adult; Analgesics; Anesthetics, Intravenous; Double-Blind Method; Female; Humans; Injections, Intrav

2006
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
A ketamine-propofol admixture does not reduce the pain on injection compared with a lidocaine-propofol admixture.
    Paediatric anaesthesia, 2007, Volume: 17, Issue:8

    Topics: Anesthesia; Anesthetics, Intravenous; Child; Child, Preschool; Double-Blind Method; Drug Combination

2007
Effect of a peripheral NMDA receptor antagonist on glutamate-evoked masseter muscle pain and mechanical sensitization in women.
    Journal of orofacial pain, 2007,Summer, Volume: 21, Issue:3

    Topics: Adult; Analgesics; Analysis of Variance; Contraceptives, Oral; Excitatory Amino Acid Antagonists; Fe

2007
Painless injection of propofol: pretreatment with ketamine vs thiopental, meperidine, and lidocaine.
    Middle East journal of anaesthesiology, 2007, Volume: 19, Issue:3

    Topics: Adult; Analgesics, Opioid; Anesthetics, Dissociative; Anesthetics, Intravenous; Anesthetics, Local;

2007
Painless injection of propofol: pretreatment with ketamine vs thiopental, meperidine, and lidocaine.
    Middle East journal of anaesthesiology, 2007, Volume: 19, Issue:3

    Topics: Adult; Analgesics, Opioid; Anesthetics, Dissociative; Anesthetics, Intravenous; Anesthetics, Local;

2007
Painless injection of propofol: pretreatment with ketamine vs thiopental, meperidine, and lidocaine.
    Middle East journal of anaesthesiology, 2007, Volume: 19, Issue:3

    Topics: Adult; Analgesics, Opioid; Anesthetics, Dissociative; Anesthetics, Intravenous; Anesthetics, Local;

2007
Painless injection of propofol: pretreatment with ketamine vs thiopental, meperidine, and lidocaine.
    Middle East journal of anaesthesiology, 2007, Volume: 19, Issue:3

    Topics: Adult; Analgesics, Opioid; Anesthetics, Dissociative; Anesthetics, Intravenous; Anesthetics, Local;

2007
Propofol-ketamine vs propofol-fentanyl combinations for deep sedation and analgesia in pediatric patients undergoing burn dressing changes.
    Paediatric anaesthesia, 2008, Volume: 18, Issue:1

    Topics: Analgesia; Anesthetics, Dissociative; Anesthetics, Intravenous; Bandages; Blood Pressure; Burns; Chi

2008
Efficacy of ketamine in anesthetic dosage for the treatment of refractory complex regional pain syndrome: an open-label phase II study.
    Pain medicine (Malden, Mass.), 2008, Volume: 9, Issue:8

    Topics: Activities of Daily Living; Adolescent; Anesthetics, Dissociative; Complex Regional Pain Syndromes;

2008
Follow-up of pain processing recovery after ketamine in hyperalgesic fibromyalgia patients using brain perfusion ECD-SPECT.
    European journal of nuclear medicine and molecular imaging, 2007, Volume: 34, Issue:12

    Topics: Adult; Aged; Anesthetics, Dissociative; Brain; Cysteine; Female; Fibromyalgia; Follow-Up Studies; Hu

2007
Chronic phantom limb pain: the effects of calcitonin, ketamine, and their combination on pain and sensory thresholds.
    Anesthesia and analgesia, 2008, Volume: 106, Issue:4

    Topics: Analgesics; Calcitonin; Computers; Cross-Over Studies; Double-Blind Method; Drug Therapy, Combinatio

2008
Effects of a low dose infusion of racemic and S-ketamine on the nociceptive withdrawal reflex in standing ponies.
    Veterinary anaesthesia and analgesia, 2008, Volume: 35, Issue:5

    Topics: Animals; Cross-Over Studies; Horses; Ketamine; Male; Pain; Reflex

2008
The effect of N-methyl-D-aspartate antagonist (ketamine) on single and repeated nociceptive stimuli: a placebo-controlled experimental human study.
    Anesthesia and analgesia, 1995, Volume: 81, Issue:1

    Topics: Analgesics; Cross-Over Studies; Double-Blind Method; Electric Stimulation; Electromyography; Evoked

1995
Central nervous system effects of subdissociative doses of (S)-ketamine are related to plasma and brain concentrations measured with positron emission tomography in healthy volunteers.
    Clinical pharmacology and therapeutics, 1995, Volume: 58, Issue:2

    Topics: Adult; Affect; Brain; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Hum

1995
Central nervous system effects of subdissociative doses of (S)-ketamine are related to plasma and brain concentrations measured with positron emission tomography in healthy volunteers.
    Clinical pharmacology and therapeutics, 1995, Volume: 58, Issue:2

    Topics: Adult; Affect; Brain; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Hum

1995
Central nervous system effects of subdissociative doses of (S)-ketamine are related to plasma and brain concentrations measured with positron emission tomography in healthy volunteers.
    Clinical pharmacology and therapeutics, 1995, Volume: 58, Issue:2

    Topics: Adult; Affect; Brain; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Hum

1995
Central nervous system effects of subdissociative doses of (S)-ketamine are related to plasma and brain concentrations measured with positron emission tomography in healthy volunteers.
    Clinical pharmacology and therapeutics, 1995, Volume: 58, Issue:2

    Topics: Adult; Affect; Brain; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Hum

1995
Central nervous system effects of subdissociative doses of (S)-ketamine are related to plasma and brain concentrations measured with positron emission tomography in healthy volunteers.
    Clinical pharmacology and therapeutics, 1995, Volume: 58, Issue:2

    Topics: Adult; Affect; Brain; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Hum

1995
Central nervous system effects of subdissociative doses of (S)-ketamine are related to plasma and brain concentrations measured with positron emission tomography in healthy volunteers.
    Clinical pharmacology and therapeutics, 1995, Volume: 58, Issue:2

    Topics: Adult; Affect; Brain; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Hum

1995
Central nervous system effects of subdissociative doses of (S)-ketamine are related to plasma and brain concentrations measured with positron emission tomography in healthy volunteers.
    Clinical pharmacology and therapeutics, 1995, Volume: 58, Issue:2

    Topics: Adult; Affect; Brain; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Hum

1995
Central nervous system effects of subdissociative doses of (S)-ketamine are related to plasma and brain concentrations measured with positron emission tomography in healthy volunteers.
    Clinical pharmacology and therapeutics, 1995, Volume: 58, Issue:2

    Topics: Adult; Affect; Brain; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Hum

1995
Central nervous system effects of subdissociative doses of (S)-ketamine are related to plasma and brain concentrations measured with positron emission tomography in healthy volunteers.
    Clinical pharmacology and therapeutics, 1995, Volume: 58, Issue:2

    Topics: Adult; Affect; Brain; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Hum

1995
Conscious sedation by rectal administration of midazolam or midazolam plus ketamine as alternatives to general anesthesia for dental treatment of uncooperative children.
    Scandinavian journal of dental research, 1994, Volume: 102, Issue:5

    Topics: Anesthesia, Dental; Anesthesia, Local; Anesthesia, Rectal; Behavior Therapy; Child; Child Behavior;

1994
The influence of adenosine, ketamine, and morphine on experimentally induced ischemic pain in healthy volunteers.
    Anesthesia and analgesia, 1994, Volume: 79, Issue:4

    Topics: Adenosine; Adult; Drug Interactions; Drug Therapy, Combination; Female; Humans; Ischemia; Ketamine;

1994
Response of chronic neuropathic pain syndromes to ketamine: a preliminary study.
    Pain, 1994, Volume: 56, Issue:1

    Topics: Adult; Aged; Chronic Disease; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans;

1994
Central dysesthesia pain after traumatic spinal cord injury is dependent on N-methyl-D-aspartate receptor activation.
    Neurosurgery, 1995, Volume: 37, Issue:6

    Topics: Adult; Aged; Alfentanil; Analgesics, Opioid; Double-Blind Method; Excitatory Amino Acid Antagonists;

1995
Pain analysis in patients with fibromyalgia. Effects of intravenous morphine, lidocaine, and ketamine.
    Scandinavian journal of rheumatology, 1995, Volume: 24, Issue:6

    Topics: Adult; Analgesics, Opioid; Anesthetics, Dissociative; Anesthetics, Local; Double-Blind Method; Femal

1995
Pain analysis in patients with fibromyalgia. Effects of intravenous morphine, lidocaine, and ketamine.
    Scandinavian journal of rheumatology, 1995, Volume: 24, Issue:6

    Topics: Adult; Analgesics, Opioid; Anesthetics, Dissociative; Anesthetics, Local; Double-Blind Method; Femal

1995
Pain analysis in patients with fibromyalgia. Effects of intravenous morphine, lidocaine, and ketamine.
    Scandinavian journal of rheumatology, 1995, Volume: 24, Issue:6

    Topics: Adult; Analgesics, Opioid; Anesthetics, Dissociative; Anesthetics, Local; Double-Blind Method; Femal

1995
Pain analysis in patients with fibromyalgia. Effects of intravenous morphine, lidocaine, and ketamine.
    Scandinavian journal of rheumatology, 1995, Volume: 24, Issue:6

    Topics: Adult; Analgesics, Opioid; Anesthetics, Dissociative; Anesthetics, Local; Double-Blind Method; Femal

1995
Effects of intravenous ketamine, alfentanil, or placebo on pain, pinprick hyperalgesia, and allodynia produced by intradermal capsaicin in human subjects.
    Pain, 1995, Volume: 63, Issue:2

    Topics: Adult; Alfentanil; Analgesics; Anesthetics, Intravenous; Capsaicin; Cross-Over Studies; Double-Blind

1995
Intravenous infusion of the NMDA antagonist, ketamine, in chronic posttraumatic pain with allodynia: a double-blind comparison to alfentanil and placebo.
    Clinical neuropharmacology, 1995, Volume: 18, Issue:4

    Topics: Adult; Alfentanil; Double-Blind Method; Female; Humans; Infusions, Intravenous; Ketamine; Middle Age

1995
Analgesia for acute musculoskeletal trauma: low-dose subcutaneous infusion of ketamine.
    Anaesthesia and intensive care, 1996, Volume: 24, Issue:1

    Topics: Adult; Analgesia; Double-Blind Method; Female; Humans; Infusions, Parenteral; Ketamine; Male; Morphi

1996
Analgesia for acute musculoskeletal trauma: low-dose subcutaneous infusion of ketamine.
    Anaesthesia and intensive care, 1996, Volume: 24, Issue:1

    Topics: Adult; Analgesia; Double-Blind Method; Female; Humans; Infusions, Parenteral; Ketamine; Male; Morphi

1996
Analgesia for acute musculoskeletal trauma: low-dose subcutaneous infusion of ketamine.
    Anaesthesia and intensive care, 1996, Volume: 24, Issue:1

    Topics: Adult; Analgesia; Double-Blind Method; Female; Humans; Infusions, Parenteral; Ketamine; Male; Morphi

1996
Analgesia for acute musculoskeletal trauma: low-dose subcutaneous infusion of ketamine.
    Anaesthesia and intensive care, 1996, Volume: 24, Issue:1

    Topics: Adult; Analgesia; Double-Blind Method; Female; Humans; Infusions, Parenteral; Ketamine; Male; Morphi

1996
Analgesia for acute musculoskeletal trauma: low-dose subcutaneous infusion of ketamine.
    Anaesthesia and intensive care, 1996, Volume: 24, Issue:1

    Topics: Adult; Analgesia; Double-Blind Method; Female; Humans; Infusions, Parenteral; Ketamine; Male; Morphi

1996
Analgesia for acute musculoskeletal trauma: low-dose subcutaneous infusion of ketamine.
    Anaesthesia and intensive care, 1996, Volume: 24, Issue:1

    Topics: Adult; Analgesia; Double-Blind Method; Female; Humans; Infusions, Parenteral; Ketamine; Male; Morphi

1996
Analgesia for acute musculoskeletal trauma: low-dose subcutaneous infusion of ketamine.
    Anaesthesia and intensive care, 1996, Volume: 24, Issue:1

    Topics: Adult; Analgesia; Double-Blind Method; Female; Humans; Infusions, Parenteral; Ketamine; Male; Morphi

1996
Analgesia for acute musculoskeletal trauma: low-dose subcutaneous infusion of ketamine.
    Anaesthesia and intensive care, 1996, Volume: 24, Issue:1

    Topics: Adult; Analgesia; Double-Blind Method; Female; Humans; Infusions, Parenteral; Ketamine; Male; Morphi

1996
Analgesia for acute musculoskeletal trauma: low-dose subcutaneous infusion of ketamine.
    Anaesthesia and intensive care, 1996, Volume: 24, Issue:1

    Topics: Adult; Analgesia; Double-Blind Method; Female; Humans; Infusions, Parenteral; Ketamine; Male; Morphi

1996
Analgesia for acute musculoskeletal trauma: low-dose subcutaneous infusion of ketamine.
    Anaesthesia and intensive care, 1996, Volume: 24, Issue:1

    Topics: Adult; Analgesia; Double-Blind Method; Female; Humans; Infusions, Parenteral; Ketamine; Male; Morphi

1996
Analgesia for acute musculoskeletal trauma: low-dose subcutaneous infusion of ketamine.
    Anaesthesia and intensive care, 1996, Volume: 24, Issue:1

    Topics: Adult; Analgesia; Double-Blind Method; Female; Humans; Infusions, Parenteral; Ketamine; Male; Morphi

1996
Analgesia for acute musculoskeletal trauma: low-dose subcutaneous infusion of ketamine.
    Anaesthesia and intensive care, 1996, Volume: 24, Issue:1

    Topics: Adult; Analgesia; Double-Blind Method; Female; Humans; Infusions, Parenteral; Ketamine; Male; Morphi

1996
Analgesia for acute musculoskeletal trauma: low-dose subcutaneous infusion of ketamine.
    Anaesthesia and intensive care, 1996, Volume: 24, Issue:1

    Topics: Adult; Analgesia; Double-Blind Method; Female; Humans; Infusions, Parenteral; Ketamine; Male; Morphi

1996
Analgesia for acute musculoskeletal trauma: low-dose subcutaneous infusion of ketamine.
    Anaesthesia and intensive care, 1996, Volume: 24, Issue:1

    Topics: Adult; Analgesia; Double-Blind Method; Female; Humans; Infusions, Parenteral; Ketamine; Male; Morphi

1996
Analgesia for acute musculoskeletal trauma: low-dose subcutaneous infusion of ketamine.
    Anaesthesia and intensive care, 1996, Volume: 24, Issue:1

    Topics: Adult; Analgesia; Double-Blind Method; Female; Humans; Infusions, Parenteral; Ketamine; Male; Morphi

1996
Analgesia for acute musculoskeletal trauma: low-dose subcutaneous infusion of ketamine.
    Anaesthesia and intensive care, 1996, Volume: 24, Issue:1

    Topics: Adult; Analgesia; Double-Blind Method; Female; Humans; Infusions, Parenteral; Ketamine; Male; Morphi

1996
Intrathecal ketamine reduces morphine requirements in patients with terminal cancer pain.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1996, Volume: 43, Issue:4

    Topics: Adult; Aged; Analgesics, Opioid; Cross-Over Studies; Double-Blind Method; Excitatory Amino Acid Anta

1996
NMDA receptor blockade in chronic neuropathic pain: a comparison of ketamine and magnesium chloride.
    Pain, 1996, Volume: 64, Issue:2

    Topics: Adult; Aged; Anesthetics, Dissociative; Chronic Disease; Double-Blind Method; Female; Humans; Hypera

1996
NMDA receptor blockade in chronic neuropathic pain: a comparison of ketamine and magnesium chloride.
    Pain, 1996, Volume: 64, Issue:2

    Topics: Adult; Aged; Anesthetics, Dissociative; Chronic Disease; Double-Blind Method; Female; Humans; Hypera

1996
NMDA receptor blockade in chronic neuropathic pain: a comparison of ketamine and magnesium chloride.
    Pain, 1996, Volume: 64, Issue:2

    Topics: Adult; Aged; Anesthetics, Dissociative; Chronic Disease; Double-Blind Method; Female; Humans; Hypera

1996
NMDA receptor blockade in chronic neuropathic pain: a comparison of ketamine and magnesium chloride.
    Pain, 1996, Volume: 64, Issue:2

    Topics: Adult; Aged; Anesthetics, Dissociative; Chronic Disease; Double-Blind Method; Female; Humans; Hypera

1996
NMDA receptor blockade in chronic neuropathic pain: a comparison of ketamine and magnesium chloride.
    Pain, 1996, Volume: 64, Issue:2

    Topics: Adult; Aged; Anesthetics, Dissociative; Chronic Disease; Double-Blind Method; Female; Humans; Hypera

1996
NMDA receptor blockade in chronic neuropathic pain: a comparison of ketamine and magnesium chloride.
    Pain, 1996, Volume: 64, Issue:2

    Topics: Adult; Aged; Anesthetics, Dissociative; Chronic Disease; Double-Blind Method; Female; Humans; Hypera

1996
NMDA receptor blockade in chronic neuropathic pain: a comparison of ketamine and magnesium chloride.
    Pain, 1996, Volume: 64, Issue:2

    Topics: Adult; Aged; Anesthetics, Dissociative; Chronic Disease; Double-Blind Method; Female; Humans; Hypera

1996
NMDA receptor blockade in chronic neuropathic pain: a comparison of ketamine and magnesium chloride.
    Pain, 1996, Volume: 64, Issue:2

    Topics: Adult; Aged; Anesthetics, Dissociative; Chronic Disease; Double-Blind Method; Female; Humans; Hypera

1996
NMDA receptor blockade in chronic neuropathic pain: a comparison of ketamine and magnesium chloride.
    Pain, 1996, Volume: 64, Issue:2

    Topics: Adult; Aged; Anesthetics, Dissociative; Chronic Disease; Double-Blind Method; Female; Humans; Hypera

1996
Effect of racemic mixture and the (S+)-isomer of ketamine on temporal and spatial summation of pain.
    British journal of anaesthesia, 1996, Volume: 77, Issue:5

    Topics: Adult; Anesthetics, Dissociative; Cross-Over Studies; Double-Blind Method; Electric Stimulation; Hot

1996
Effect of racemic mixture and the (S+)-isomer of ketamine on temporal and spatial summation of pain.
    British journal of anaesthesia, 1996, Volume: 77, Issue:5

    Topics: Adult; Anesthetics, Dissociative; Cross-Over Studies; Double-Blind Method; Electric Stimulation; Hot

1996
Effect of racemic mixture and the (S+)-isomer of ketamine on temporal and spatial summation of pain.
    British journal of anaesthesia, 1996, Volume: 77, Issue:5

    Topics: Adult; Anesthetics, Dissociative; Cross-Over Studies; Double-Blind Method; Electric Stimulation; Hot

1996
Effect of racemic mixture and the (S+)-isomer of ketamine on temporal and spatial summation of pain.
    British journal of anaesthesia, 1996, Volume: 77, Issue:5

    Topics: Adult; Anesthetics, Dissociative; Cross-Over Studies; Double-Blind Method; Electric Stimulation; Hot

1996
Effect of racemic mixture and the (S+)-isomer of ketamine on temporal and spatial summation of pain.
    British journal of anaesthesia, 1996, Volume: 77, Issue:5

    Topics: Adult; Anesthetics, Dissociative; Cross-Over Studies; Double-Blind Method; Electric Stimulation; Hot

1996
Effect of racemic mixture and the (S+)-isomer of ketamine on temporal and spatial summation of pain.
    British journal of anaesthesia, 1996, Volume: 77, Issue:5

    Topics: Adult; Anesthetics, Dissociative; Cross-Over Studies; Double-Blind Method; Electric Stimulation; Hot

1996
Effect of racemic mixture and the (S+)-isomer of ketamine on temporal and spatial summation of pain.
    British journal of anaesthesia, 1996, Volume: 77, Issue:5

    Topics: Adult; Anesthetics, Dissociative; Cross-Over Studies; Double-Blind Method; Electric Stimulation; Hot

1996
Effect of racemic mixture and the (S+)-isomer of ketamine on temporal and spatial summation of pain.
    British journal of anaesthesia, 1996, Volume: 77, Issue:5

    Topics: Adult; Anesthetics, Dissociative; Cross-Over Studies; Double-Blind Method; Electric Stimulation; Hot

1996
Effect of racemic mixture and the (S+)-isomer of ketamine on temporal and spatial summation of pain.
    British journal of anaesthesia, 1996, Volume: 77, Issue:5

    Topics: Adult; Anesthetics, Dissociative; Cross-Over Studies; Double-Blind Method; Electric Stimulation; Hot

1996
Oral ketamine therapy in the treatment of postamputation stump pain.
    Acta anaesthesiologica Scandinavica, 1997, Volume: 41, Issue:3

    Topics: Administration, Oral; Amputation Stumps; Excitatory Amino Acid Antagonists; Humans; Ketamine; Leg; M

1997
Fibromyalgia--are there different mechanisms in the processing of pain? A double blind crossover comparison of analgesic drugs.
    The Journal of rheumatology, 1997, Volume: 24, Issue:8

    Topics: Adult; Anesthetics, Dissociative; Area Under Curve; Cross-Over Studies; Double-Blind Method; Drug Th

1997
Pharmacological classification of central post-stroke pain: comparison with the results of chronic motor cortex stimulation therapy.
    Pain, 1997, Volume: 72, Issue:1-2

    Topics: Adult; Aged; Analgesics, Opioid; Anesthetics; Cerebrovascular Disorders; Female; Humans; Ketamine; L

1997
The effect of ketamine pretreatment on propofol injection pain in 100 women.
    Anaesthesia, 1998, Volume: 53, Issue:3

    Topics: Adolescent; Adult; Aged; Anesthetics, Dissociative; Anesthetics, Intravenous; Double-Blind Method; F

1998
Analgesic and cognitive effects of intravenous ketamine-alfentanil combinations versus either drug alone after intradermal capsaicin in normal subjects.
    Anesthesia and analgesia, 1998, Volume: 86, Issue:6

    Topics: Adult; Alfentanil; Analgesics; Analgesics, Opioid; Anesthetics, Dissociative; Capsaicin; Cognition;

1998
Peripheral analgesic effects of ketamine in acute inflammatory pain.
    Anesthesiology, 1998, Volume: 89, Issue:1

    Topics: Administration, Cutaneous; Adult; Anesthetics, Dissociative; Double-Blind Method; Female; Humans; In

1998
Peripheral analgesic effects of ketamine in acute inflammatory pain.
    Anesthesiology, 1998, Volume: 89, Issue:1

    Topics: Administration, Cutaneous; Adult; Anesthetics, Dissociative; Double-Blind Method; Female; Humans; In

1998
Peripheral analgesic effects of ketamine in acute inflammatory pain.
    Anesthesiology, 1998, Volume: 89, Issue:1

    Topics: Administration, Cutaneous; Adult; Anesthetics, Dissociative; Double-Blind Method; Female; Humans; In

1998
Peripheral analgesic effects of ketamine in acute inflammatory pain.
    Anesthesiology, 1998, Volume: 89, Issue:1

    Topics: Administration, Cutaneous; Adult; Anesthetics, Dissociative; Double-Blind Method; Female; Humans; In

1998
The analgesic effect of racemic ketamine in patients with chronic ischemic pain due to lower extremity arteriosclerosis obliterans.
    Acta anaesthesiologica Scandinavica, 1998, Volume: 42, Issue:7

    Topics: Aged; Aged, 80 and over; Analgesics; Analgesics, Opioid; Arteriosclerosis Obliterans; Chromatography

1998
Comparison of fentanyl/midazolam with ketamine/midazolam for pediatric orthopedic emergencies.
    Pediatrics, 1998, Volume: 102, Issue:4 Pt 1

    Topics: Adolescent; Analgesics, Opioid; Anesthetics, Dissociative; Anti-Anxiety Agents; Anxiety; Child; Chil

1998
Comparison of fentanyl/midazolam with ketamine/midazolam for pediatric orthopedic emergencies.
    Pediatrics, 1998, Volume: 102, Issue:4 Pt 1

    Topics: Adolescent; Analgesics, Opioid; Anesthetics, Dissociative; Anti-Anxiety Agents; Anxiety; Child; Chil

1998
Comparison of fentanyl/midazolam with ketamine/midazolam for pediatric orthopedic emergencies.
    Pediatrics, 1998, Volume: 102, Issue:4 Pt 1

    Topics: Adolescent; Analgesics, Opioid; Anesthetics, Dissociative; Anti-Anxiety Agents; Anxiety; Child; Chil

1998
Comparison of fentanyl/midazolam with ketamine/midazolam for pediatric orthopedic emergencies.
    Pediatrics, 1998, Volume: 102, Issue:4 Pt 1

    Topics: Adolescent; Analgesics, Opioid; Anesthetics, Dissociative; Anti-Anxiety Agents; Anxiety; Child; Chil

1998
Comparison of fentanyl/midazolam with ketamine/midazolam for pediatric orthopedic emergencies.
    Pediatrics, 1998, Volume: 102, Issue:4 Pt 1

    Topics: Adolescent; Analgesics, Opioid; Anesthetics, Dissociative; Anti-Anxiety Agents; Anxiety; Child; Chil

1998
Comparison of fentanyl/midazolam with ketamine/midazolam for pediatric orthopedic emergencies.
    Pediatrics, 1998, Volume: 102, Issue:4 Pt 1

    Topics: Adolescent; Analgesics, Opioid; Anesthetics, Dissociative; Anti-Anxiety Agents; Anxiety; Child; Chil

1998
Comparison of fentanyl/midazolam with ketamine/midazolam for pediatric orthopedic emergencies.
    Pediatrics, 1998, Volume: 102, Issue:4 Pt 1

    Topics: Adolescent; Analgesics, Opioid; Anesthetics, Dissociative; Anti-Anxiety Agents; Anxiety; Child; Chil

1998
Comparison of fentanyl/midazolam with ketamine/midazolam for pediatric orthopedic emergencies.
    Pediatrics, 1998, Volume: 102, Issue:4 Pt 1

    Topics: Adolescent; Analgesics, Opioid; Anesthetics, Dissociative; Anti-Anxiety Agents; Anxiety; Child; Chil

1998
Comparison of fentanyl/midazolam with ketamine/midazolam for pediatric orthopedic emergencies.
    Pediatrics, 1998, Volume: 102, Issue:4 Pt 1

    Topics: Adolescent; Analgesics, Opioid; Anesthetics, Dissociative; Anti-Anxiety Agents; Anxiety; Child; Chil

1998
Prolonged analgesic effect of ketamine, an N-methyl-D-aspartate receptor inhibitor, in patients with chronic pain.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 289, Issue:2

    Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Chronic Disease; Cross-Over Studies; Double-Bl

1999
Clinical experience with oral ketamine.
    Journal of pain and symptom management, 1999, Volume: 17, Issue:5

    Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Analgesics; Chronic Disease; Female; Humans; K

1999
Midazolam/ketamine sedative combination compared with fentanyl/propofol/isoflurane anaesthesia for oocyte retrieval.
    Human reproduction (Oxford, England), 1999, Volume: 14, Issue:7

    Topics: Adult; Anesthesia, General; Anesthetics; Female; Fentanyl; Humans; Hypnotics and Sedatives; Isoflura

1999
N of 1 randomised controlled trials of oral ketamine in patients with chronic pain.
    Pain, 1999, Volume: 83, Issue:2

    Topics: Administration, Oral; Analgesics; Female; Humans; Ketamine; Male; Pain; Placebos

1999
The effects of ketamine on the temporal summation (wind-up) of the R(III) nociceptive flexion reflex and pain in humans.
    Anesthesia and analgesia, 2000, Volume: 90, Issue:2

    Topics: Adult; Anesthetics, Dissociative; Cross-Over Studies; Double-Blind Method; Electric Stimulation; Hum

2000
Painless invasive procedures.
    Indian pediatrics, 1999, Volume: 36, Issue:10

    Topics: Administration, Oral; Analgesics; Anesthetics, Dissociative; Child; Child, Preschool; Diagnostic Tec

1999
Potency of propofol, thiopentone and ketamine at various endpoints in New Zealand White rabbits.
    Laboratory animals, 2000, Volume: 34, Issue:1

    Topics: Anesthetics, Intravenous; Animals; Central Nervous System; Ketamine; Pain; Posture; Propofol; Rabbit

2000
Ketamine reduces muscle pain, temporal summation, and referred pain in fibromyalgia patients.
    Pain, 2000, Volume: 85, Issue:3

    Topics: Adult; Anesthetics, Dissociative; Double-Blind Method; Electric Stimulation; Excitatory Amino Acid A

2000
Ketamine reduces muscle pain, temporal summation, and referred pain in fibromyalgia patients.
    Pain, 2000, Volume: 85, Issue:3

    Topics: Adult; Anesthetics, Dissociative; Double-Blind Method; Electric Stimulation; Excitatory Amino Acid A

2000
Ketamine reduces muscle pain, temporal summation, and referred pain in fibromyalgia patients.
    Pain, 2000, Volume: 85, Issue:3

    Topics: Adult; Anesthetics, Dissociative; Double-Blind Method; Electric Stimulation; Excitatory Amino Acid A

2000
Ketamine reduces muscle pain, temporal summation, and referred pain in fibromyalgia patients.
    Pain, 2000, Volume: 85, Issue:3

    Topics: Adult; Anesthetics, Dissociative; Double-Blind Method; Electric Stimulation; Excitatory Amino Acid A

2000
Preinjury treatment with morphine or ketamine inhibits the development of experimentally induced secondary hyperalgesia in man.
    Pain, 2000, Volume: 86, Issue:3

    Topics: Adult; Analgesics; Analgesics, Opioid; Burns; Cross-Over Studies; Double-Blind Method; Excitatory Am

2000
Ketamine for procedural pain relief in newborn infants.
    Archives of disease in childhood. Fetal and neonatal edition, 2001, Volume: 85, Issue:1

    Topics: Analgesics; Blood Pressure; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Metho

2001
Low dose intravenous ketamine as an analgesic: a pilot study using an experimental model of acute pain.
    The American journal of emergency medicine, 2001, Volume: 19, Issue:6

    Topics: Acute Disease; Adult; Anesthetics, Dissociative; Double-Blind Method; Female; Humans; Infusions, Int

2001
Low dose intravenous ketamine as an analgesic: a pilot study using an experimental model of acute pain.
    The American journal of emergency medicine, 2001, Volume: 19, Issue:6

    Topics: Acute Disease; Adult; Anesthetics, Dissociative; Double-Blind Method; Female; Humans; Infusions, Int

2001
Low dose intravenous ketamine as an analgesic: a pilot study using an experimental model of acute pain.
    The American journal of emergency medicine, 2001, Volume: 19, Issue:6

    Topics: Acute Disease; Adult; Anesthetics, Dissociative; Double-Blind Method; Female; Humans; Infusions, Int

2001
Low dose intravenous ketamine as an analgesic: a pilot study using an experimental model of acute pain.
    The American journal of emergency medicine, 2001, Volume: 19, Issue:6

    Topics: Acute Disease; Adult; Anesthetics, Dissociative; Double-Blind Method; Female; Humans; Infusions, Int

2001
Low dose intravenous ketamine as an analgesic: a pilot study using an experimental model of acute pain.
    The American journal of emergency medicine, 2001, Volume: 19, Issue:6

    Topics: Acute Disease; Adult; Anesthetics, Dissociative; Double-Blind Method; Female; Humans; Infusions, Int

2001
Low dose intravenous ketamine as an analgesic: a pilot study using an experimental model of acute pain.
    The American journal of emergency medicine, 2001, Volume: 19, Issue:6

    Topics: Acute Disease; Adult; Anesthetics, Dissociative; Double-Blind Method; Female; Humans; Infusions, Int

2001
Low dose intravenous ketamine as an analgesic: a pilot study using an experimental model of acute pain.
    The American journal of emergency medicine, 2001, Volume: 19, Issue:6

    Topics: Acute Disease; Adult; Anesthetics, Dissociative; Double-Blind Method; Female; Humans; Infusions, Int

2001
Low dose intravenous ketamine as an analgesic: a pilot study using an experimental model of acute pain.
    The American journal of emergency medicine, 2001, Volume: 19, Issue:6

    Topics: Acute Disease; Adult; Anesthetics, Dissociative; Double-Blind Method; Female; Humans; Infusions, Int

2001
Low dose intravenous ketamine as an analgesic: a pilot study using an experimental model of acute pain.
    The American journal of emergency medicine, 2001, Volume: 19, Issue:6

    Topics: Acute Disease; Adult; Anesthetics, Dissociative; Double-Blind Method; Female; Humans; Infusions, Int

2001
Low dose intravenous ketamine as an analgesic: a pilot study using an experimental model of acute pain.
    The American journal of emergency medicine, 2001, Volume: 19, Issue:6

    Topics: Acute Disease; Adult; Anesthetics, Dissociative; Double-Blind Method; Female; Humans; Infusions, Int

2001
Low dose intravenous ketamine as an analgesic: a pilot study using an experimental model of acute pain.
    The American journal of emergency medicine, 2001, Volume: 19, Issue:6

    Topics: Acute Disease; Adult; Anesthetics, Dissociative; Double-Blind Method; Female; Humans; Infusions, Int

2001
Low dose intravenous ketamine as an analgesic: a pilot study using an experimental model of acute pain.
    The American journal of emergency medicine, 2001, Volume: 19, Issue:6

    Topics: Acute Disease; Adult; Anesthetics, Dissociative; Double-Blind Method; Female; Humans; Infusions, Int

2001
Low dose intravenous ketamine as an analgesic: a pilot study using an experimental model of acute pain.
    The American journal of emergency medicine, 2001, Volume: 19, Issue:6

    Topics: Acute Disease; Adult; Anesthetics, Dissociative; Double-Blind Method; Female; Humans; Infusions, Int

2001
Low dose intravenous ketamine as an analgesic: a pilot study using an experimental model of acute pain.
    The American journal of emergency medicine, 2001, Volume: 19, Issue:6

    Topics: Acute Disease; Adult; Anesthetics, Dissociative; Double-Blind Method; Female; Humans; Infusions, Int

2001
Low dose intravenous ketamine as an analgesic: a pilot study using an experimental model of acute pain.
    The American journal of emergency medicine, 2001, Volume: 19, Issue:6

    Topics: Acute Disease; Adult; Anesthetics, Dissociative; Double-Blind Method; Female; Humans; Infusions, Int

2001
Low dose intravenous ketamine as an analgesic: a pilot study using an experimental model of acute pain.
    The American journal of emergency medicine, 2001, Volume: 19, Issue:6

    Topics: Acute Disease; Adult; Anesthetics, Dissociative; Double-Blind Method; Female; Humans; Infusions, Int

2001
[Pre-treatment with ketamine reduces incidence and severity of pain on propofol injection].
    Masui. The Japanese journal of anesthesiology, 2002, Volume: 51, Issue:2

    Topics: Adult; Aged; Anesthesia, General; Double-Blind Method; Female; Humans; Injections, Intravenous; Keta

2002
On effects of ketamine to axillary block in hand surgery.
    Journal of reconstructive microsurgery, 2002, Volume: 18, Issue:3

    Topics: Adult; Anesthetics, Local; Brachial Plexus; Carticaine; Drug Combinations; Hand; Humans; Ketamine; M

2002
A single infusion of intravenous ketamine improves pain relief in patients with critical limb ischaemia: results of a double blind randomised controlled trial.
    Pain, 2002, Volume: 97, Issue:3

    Topics: Aged; Analgesics; Analgesics, Opioid; Anxiety; Depression; Double-Blind Method; Extremities; Female;

2002
Assessment of the effect of dextromethorphan and ketamine on the acute nociceptive threshold and wind-up of the second pain response in healthy male volunteers.
    British journal of clinical pharmacology, 2002, Volume: 53, Issue:6

    Topics: Acute Disease; Adult; Analgesics; Cross-Over Studies; Dextromethorphan; Dextrorphan; Dose-Response R

2002
Comparison of ketamine and pethidine in experimental and postoperative pain.
    Pain, 1989, Volume: 36, Issue:1

    Topics: Adult; Female; Humans; Ischemia; Ketamine; Meperidine; Naloxone; Pain; Pain, Postoperative; Visual P

1989
[Intravenous analgesia with ketamine for emergency patients].
    Der Anaesthesist, 1987, Volume: 36, Issue:3

    Topics: Adolescent; Adult; Aged; Emergencies; Female; Humans; Injections, Intravenous; Ketamine; Male; Middl

1987

Other Studies

345 other studies available for ketamine and Ache

ArticleYear
The authors respond: Topical ketamine for reducing venipuncture pain.
    The American journal of emergency medicine, 2022, Volume: 56

    Topics: Administration, Topical; Humans; Ketamine; Pain; Pain Measurement; Phlebotomy

2022
Topical ketamine for reducing venipuncture pain.
    The American journal of emergency medicine, 2022, Volume: 56

    Topics: Administration, Topical; Humans; Ketamine; Pain; Pain Measurement; Phlebotomy

2022
Role of Ketamine and Opioid Rotation in the Management of Opioid Induced Hyperalgesia in a Patient With Acute Promyelocytic Leukemia.
    Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners, 2022, Volume: 28, Issue:5

    Topics: Adult; Analgesics, Opioid; Cancer Pain; Female; Humans; Hyperalgesia; Ketamine; Leukemia, Promyelocy

2022
Paraphimosis Pain Treatment with Nebulized Ketamine in the Emergency Department.
    The Journal of emergency medicine, 2022, Volume: 62, Issue:3

    Topics: Acute Disease; Adolescent; Analgesics; Anesthetics, Dissociative; Child; Emergency Service, Hospital

2022
A dose-escalation clinical trial of intranasal ketamine for uncontrolled cancer-related pain.
    Pharmacotherapy, 2022, Volume: 42, Issue:4

    Topics: Adult; Analgesics; Analgesics, Opioid; Cancer Pain; Double-Blind Method; Humans; Ketamine; Neoplasms

2022
Ketamine Psychedelic and Antinociceptive Effects Are Connected.
    Anesthesiology, 2022, 05-01, Volume: 136, Issue:5

    Topics: Analgesia; Analgesics; Hallucinogens; Humans; Ketamine; Male; Pain

2022
Ketamine-precipitated syndrome of inappropriate antidiuretic hormone secretion in a patient with persistent lumbar pain: a case report.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2022, Volume: 69, Issue:5

    Topics: Drug-Related Side Effects and Adverse Reactions; Humans; Hyponatremia; Inappropriate ADH Syndrome; K

2022
Ketamine Analgesia and Psychedelia: Can We Dissociate Dissociation?
    Anesthesiology, 2022, 05-01, Volume: 136, Issue:5

    Topics: Analgesia; Humans; Ketamine; Pain; Pain Management

2022
Ketamine vs fentanyl for ED treatment of pain.
    The American journal of emergency medicine, 2022, Volume: 58

    Topics: Analgesics; Analgesics, Opioid; Double-Blind Method; Fentanyl; Humans; Ketamine; Pain

2022
Adjuvant low-dose ketamine for paediatric and young adult sickle cell vaso-occlusive episodes in the emergency department.
    British journal of haematology, 2022, Volume: 198, Issue:1

    Topics: Anemia, Sickle Cell; Child; Emergency Service, Hospital; Erythrocytes, Abnormal; Humans; Ketamine; P

2022
Intravenous Ketamine Infusion as an Adjunctive Pain Treatment for Erythromelalgia: A Pediatric Case Report.
    A&A practice, 2022, Apr-13, Volume: 16, Issue:4

    Topics: Analgesics; Child; Erythromelalgia; Female; Humans; Ketamine; Pain; Pain Management

2022
Prospective association of psychological pain and hopelessness with suicidal thoughts.
    Journal of affective disorders, 2022, 07-01, Volume: 308

    Topics: Depressive Disorder, Major; Depressive Disorder, Treatment-Resistant; Humans; Ketamine; Pain; Suicid

2022
Procedural Sedation With Dexmedetomidine in Combination With Ketamine in the Emergency Department.
    The Journal of emergency medicine, 2022, Volume: 63, Issue:2

    Topics: Anesthetics, Dissociative; Conscious Sedation; Dexmedetomidine; Drug Combinations; Emergency Service

2022
Opioid sparing effect of ketamine in military prehospital pain management-A retrospective study.
    The journal of trauma and acute care surgery, 2022, 08-01, Volume: 93, Issue:2S Suppl 1

    Topics: Analgesics; Analgesics, Opioid; Emergency Medical Services; Humans; Ketamine; Military Personnel; Pa

2022
Battlefield pain summit 2022: Expert consensus statements.
    The journal of trauma and acute care surgery, 2022, 08-01, Volume: 93, Issue:2S Suppl 1

    Topics: Analgesics; Analgesics, Non-Narcotic; Humans; Ketamine; Military Medicine; Pain; Pain Management

2022
Role of intraoperative ketamine in preventing severe rebound pain for patients undergoing ambulatory upper extremity surgery. Comment on Br J Anaesth 2022; 128: 734-41.
    British journal of anaesthesia, 2022, Volume: 129, Issue:2

    Topics: Humans; Ketamine; Nerve Block; Pain; Pain Management; Upper Extremity

2022
The N-methyl-D-aspartate receptor antagonist ketamin exerts analgesic effects via modulation of the nitric oxide pathway.
    Fundamental & clinical pharmacology, 2022, Volume: 36, Issue:6

    Topics: Analgesics; Animals; Ketamine; Mice; Nitric Oxide; Nitric Oxide Synthase; Pain; Receptors, N-Methyl-

2022
Nebulized Ketamine for Analgesia in the Prehospital Setting: A Case Series.
    Prehospital emergency care, 2023, Volume: 27, Issue:2

    Topics: Analgesia; Analgesics; Emergency Medical Services; Humans; Ketamine; Pain; Pain Management

2023
Novel uses of ketamine in the emergency department.
    Expert opinion on drug safety, 2022, Volume: 21, Issue:8

    Topics: Analgesics, Opioid; Drug Tolerance; Emergency Service, Hospital; Humans; Ketamine; Morphine; Pain

2022
Effect of sedation using Ketamine for primary closure of pediatric facial laceration.
    Medicine, 2022, Aug-12, Volume: 101, Issue:32

    Topics: Child; Conscious Sedation; Facial Injuries; Humans; Hypnotics and Sedatives; Infant; Ketamine; Lacer

2022
A subclinical dose of esketamine pretreatment for propofol and rocuronium injection pain.
    Asian journal of surgery, 2022, Volume: 45, Issue:12

    Topics: Humans; Ketamine; Pain; Propofol; Rocuronium

2022
Suspected opioid-induced hyperalgesia in an infant following surgery: A case report.
    Journal of clinical pharmacy and therapeutics, 2022, Volume: 47, Issue:9

    Topics: Adult; Analgesics, Opioid; Fentanyl; Humans; Hyperalgesia; Infant; Ketamine; Male; Pain

2022
Ketamine in Total Joint Arthroplasty: The Clinical Practice Guidelines of the American Association of Hip and Knee Surgeons, American Society of Regional Anesthesia and Pain Medicine, American Academy of Orthopaedic Surgeons, Hip Society, and Knee Society
    The Journal of arthroplasty, 2022, Volume: 37, Issue:9

    Topics: Analgesics; Anesthesia, Conduction; Arthroplasty; Arthroplasty, Replacement, Hip; Humans; Ketamine;

2022
Effective anesthetic management with remimazolam and ketamine without muscle relaxants for parotidectomy in a patient with myotonic dystrophy: A case report.
    Medicine, 2022, Aug-26, Volume: 101, Issue:34

    Topics: Adult; Anesthetics, Intravenous; Benzodiazepines; Humans; Ketamine; Male; Muscles; Myotonic Dystroph

2022
Safety and Efficacy of Propofol- and Ketamine-Based Procedural Sedation Regimen in Pediatric Patients During Burn Repetitive Dressing Change: 10 Years Single Center Experience.
    Journal of burn care & research : official publication of the American Burn Association, 2023, 07-05, Volume: 44, Issue:4

    Topics: Bandages; Burns; Child; Child, Preschool; Humans; Hypnotics and Sedatives; Ketamine; Pain; Propofol;

2023
Sympathetic Blocks as a Predictor for Response to Ketamine Infusion in Patients with Complex Regional Pain Syndrome: A Multicenter Study.
    Pain medicine (Malden, Mass.), 2023, 03-01, Volume: 24, Issue:3

    Topics: Autonomic Nerve Block; Complex Regional Pain Syndromes; Humans; Ketamine; Pain; Reflex Sympathetic D

2023
Ketamine in Severe Leptomeningeal Pain.
    Journal of palliative medicine, 2023, Volume: 26, Issue:4

    Topics: Analgesics; Analgesics, Opioid; Humans; Ketamine; Meningeal Carcinomatosis; Pain

2023
Pre-hospital analgesia in pediatric trauma and critically ill patients: An analysis of a German air rescue service.
    Scandinavian journal of trauma, resuscitation and emergency medicine, 2023, Jan-28, Volume: 31, Issue:1

    Topics: Analgesia; Analgesics; Analgesics, Opioid; Child; Critical Illness; Emergency Medical Services; Fent

2023
Treating Prehospital Pain in Children: A Retrospective Chart Review Comparing the Safety and Efficacy of Prehospital Pediatric Ketamine and Opioid Analgesia.
    Journal of pain & palliative care pharmacotherapy, 2023, Volume: 37, Issue:2

    Topics: Adolescent; Aged, 80 and over; Analgesia; Analgesics; Analgesics, Opioid; Child; Emergency Medical S

2023
Combat Casualties Treated With Intranasal Ketamine for Prehospital Analgesia: A Case Series.
    Journal of special operations medicine : a peer reviewed journal for SOF medical professionals, 2023, Mar-15, Volume: 23, Issue:1

    Topics: Analgesia; Analgesics; Emergency Medical Services; Humans; Ketamine; Military Medicine; Pain; Pain M

2023
Ketamine use for management of vaso-occlusive pain in pediatric sickle cell disease.
    Pediatric blood & cancer, 2023, Volume: 70, Issue:5

    Topics: Adolescent; Analgesics, Opioid; Anemia, Sickle Cell; Child; Humans; Ketamine; Pain; Retrospective St

2023
The intranasal route for ketamine administration may be a simple way to improve battlefield analgesia.
    The journal of trauma and acute care surgery, 2023, 06-01, Volume: 94, Issue:6

    Topics: Analgesia; Analgesics; Humans; Ketamine; Pain; Pain Management

2023
Prospective observational study on the use of continuous intravenous ketamine and propofol infusion for prolonged sedation in critical care.
    Anales de pediatria, 2023, Volume: 98, Issue:4

    Topics: Child; Cohort Studies; Critical Care; Humans; Hypnotics and Sedatives; Ketamine; Pain; Propofol; Pro

2023
Routine Prophylactic Esketamine for the Prevention of Maternal Pain During Cesarean Delivery.
    JAMA network open, 2023, 04-03, Volume: 6, Issue:4

    Topics: Cesarean Section; Female; Humans; Ketamine; Pain; Pregnancy

2023
Ketamine infusion for pain management in hospitalized patients with Chronic Pancreatitis: A case series.
    Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 2023, Volume: 23, Issue:4

    Topics: Analgesics; Chronic Pain; Humans; Infusions, Intravenous; Ketamine; Pain; Pain Management; Pancreati

2023
Expanded indications of ketamine infusions for pediatric non-surgical pain: a 10 year, single-center experience.
    Pain medicine (Malden, Mass.), 2023, 09-01, Volume: 24, Issue:9

    Topics: Analgesics; Child; Humans; Infusions, Intravenous; Ketamine; Pain

2023
Pain mediates the improvement of social functions of repeated intravenous ketamine in patients with unipolar and bipolar depression.
    Journal of affective disorders, 2023, 08-01, Volume: 334

    Topics: Bipolar Disorder; Depression; Depressive Disorder; Depressive Disorder, Treatment-Resistant; Humans;

2023
Exploring the role of mu opioid receptors in the therapeutic potential and abuse liability of (S)-ketamine.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2024, Volume: 49, Issue:1

    Topics: Analgesics, Opioid; Humans; Ketamine; Pain; Receptors, Opioid, mu

2024
Comment on: Ketamine use for management of vaso-occlusive pain in pediatric sickle cell disease.
    Pediatric blood & cancer, 2023, Volume: 70, Issue:11

    Topics: Analgesics; Anemia, Sickle Cell; Child; Humans; Ketamine; Pain

2023
Race and Ethnicity and Prehospital Use of Opioid or Ketamine Analgesia in Acute Traumatic Injury.
    JAMA network open, 2023, 10-02, Volume: 6, Issue:10

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; American Indian or Alaska Native; Analgesia; Analgesics,

2023
The potent analgesia of intrathecal 2R, 6R-HNK via TRPA1 inhibition in LF-PENS-induced chronic primary pain model.
    The journal of headache and pain, 2023, Oct-19, Volume: 24, Issue:1

    Topics: Analgesics; Animals; Calcitonin Gene-Related Peptide; Calcium; Ketamine; Mice; Pain; Transcutaneous

2023
Reply to: Comment on: Ketamine use for management of vaso-occlusive pain in pediatric sickle cell disease.
    Pediatric blood & cancer, 2024, Volume: 71, Issue:1

    Topics: Analgesics; Anemia, Sickle Cell; Child; Humans; Ketamine; Pain

2024
Ketamine: Safe Until It's Not - A Terrifying Trip to the K-Hole.
    The Journal of emergency medicine, 2019, Volume: 57, Issue:4

    Topics: Emergency Medicine; Humans; Hypnotics and Sedatives; Ketamine; Pain; Pain Management

2019
Involvement of serotonergic and opioidergic systems in the antinociceptive effect of ketamine-magnesium sulphate combination in formalin test in rats.
    Pharmacological reports : PR, 2019, Volume: 71, Issue:6

    Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Drug Therapy, Combination; Formaldehyde; Keta

2019
Is Intranasal Ketamine Safe and Effective as a Prehospital Analgesic?
    CJEM, 2020, Volume: 22, Issue:1

    Topics: Adult; Analgesia; Analgesics; Double-Blind Method; Emergency Medical Services; Humans; Ketamine; Pai

2020
Peripheral antinociception induced by ketamine is mediated by the endogenous opioid system.
    European journal of pharmacology, 2019, Dec-15, Volume: 865

    Topics: Analgesics; Animals; Cinnamates; Dinoprostone; Ketamine; Male; Mice; Morphine Derivatives; Naloxone;

2019
KEA-1010, a ketamine ester analogue, retains analgesic and sedative potency but is devoid of Psychomimetic effects.
    BMC pharmacology & toxicology, 2019, 12-19, Volume: 20, Issue:1

    Topics: Analgesics; Animals; Behavior, Animal; Esters; Female; Hypnotics and Sedatives; Ketamine; Male; Pain

2019
The ketamine crisis: Does South Africa have a plan B?
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 2019, Nov-27, Volume: 109, Issue:12

    Topics: Analgesics; Burns; Humans; Ketamine; Pain; South Africa

2019
Analgesic efficacy of an intravenous constant rate infusion of a morphine-lidocaine-ketamine combination in Holstein calves undergoing umbilical herniorrhaphy.
    American journal of veterinary research, 2020, Volume: 81, Issue:1

    Topics: Analgesics; Animals; Cattle; Female; Hernia, Umbilical; Herniorrhaphy; Hydrocortisone; Infusions, In

2020
Ketamine Safety and Use in the Emergency Department for Pain and Agitation/Delirium: A Health System Experience.
    The western journal of emergency medicine, 2020, Jan-27, Volume: 21, Issue:2

    Topics: Adult; Analgesia; Anesthetics, Dissociative; Conscious Sedation; Delirium; Emergency Service, Hospit

2020
[Analgesia for trauma patients in emergency medicine].
    Der Anaesthesist, 2020, Volume: 69, Issue:2

    Topics: Analgesia; Emergency Medical Services; Emergency Medicine; Fentanyl; Humans; Ketamine; Pain; Pain Ma

2020
Fentanyl impairs but ketamine preserves the microcirculatory response to hemorrhage.
    The journal of trauma and acute care surgery, 2020, Volume: 89, Issue:2S Suppl 2

    Topics: Administration, Topical; Analgesics; Analgesics, Opioid; Animals; Blood Pressure; Fentanyl; Heart Ra

2020
Ketamine for Pain: The Dosing Dilemma and Missing Pieces.
    Pediatric emergency care, 2021, Dec-01, Volume: 37, Issue:12

    Topics: Analgesics; Humans; Ketamine; Pain

2021
Feasibility and impact of the implementation of a clinical scale-based sedation-analgesia protocol in severe burn patients undergoing mechanical ventilation. A before-after bi-center study.
    Burns : journal of the International Society for Burn Injuries, 2020, Volume: 46, Issue:6

    Topics: Adult; Analgesics, Opioid; Burns; Clinical Protocols; Controlled Before-After Studies; Dose-Response

2020
Repeated subcutaneous esketamine administration for depressive symptoms and pain relief in a terminally ill cancer patient: A case report.
    Palliative medicine, 2020, Volume: 34, Issue:6

    Topics: Abdominal Neoplasms; Aged; Antidepressive Agents; Depression; Humans; Ketamine; Male; Pain; Terminal

2020
Continuous Ketamine Infusion for Pain as an Opportunity for Psychotherapy for PTSD: A Case Series of Ketamine-Enhanced Psychotherapy for PTSD and Pain (KEP-P2).
    Psychotherapy and psychosomatics, 2020, Volume: 89, Issue:5

    Topics: Adult; Aged; Excitatory Amino Acid Antagonists; Female; Humans; Infusions, Intravenous; Ketamine; Ma

2020
Transient amnesia following prehospital low-dose ketamine administration.
    The American journal of emergency medicine, 2020, Volume: 38, Issue:7

    Topics: Accidental Falls; Aged; Analgesics; Anemia; Dose-Response Relationship, Drug; Emergency Medical Serv

2020
Topical Ketamine and Revision of the World Health Organization Step Ladder for Cancer Pain.
    Journal of palliative medicine, 2020, Volume: 23, Issue:9

    Topics: Analgesics; Cancer Pain; Humans; Ketamine; Neoplasms; Pain; World Health Organization

2020
Ketamine for pain control of snake envenomation in Guinea: A case series.
    Toxicon : official journal of the International Society on Toxinology, 2020, Volume: 187

    Topics: Adult; Animals; Antivenins; Female; Guinea; Humans; Ketamine; Male; Middle Aged; Pain; Pain Manageme

2020
Intravenous Ketamine Administered as Patient Controlled Analgesia and Continuous Infusion for Central Pain Syndrome.
    Journal of pain & palliative care pharmacotherapy, 2021, Volume: 35, Issue:1

    Topics: Analgesia, Patient-Controlled; Humans; Infusions, Intravenous; Ketamine; Male; Middle Aged; Pain; Pa

2021
Antinociceptive activity of 3β-6β-16β-trihydroxylup-20 (29)-ene triterpene isolated from Combretum leprosum leaves in adult zebrafish (Danio rerio).
    Biochemical and biophysical research communications, 2020, 12-10, Volume: 533, Issue:3

    Topics: Acid Sensing Ion Channels; Amiloride; Analgesics; Animals; Camphor; Capsaicin; Combretum; Dose-Respo

2020
Ketamine Use for Prolonged Field Care Reduces Supply Use.
    Journal of special operations medicine : a peer reviewed journal for SOF medical professionals, 2020,Fall, Volume: 20, Issue:3

    Topics: Adult; Analgesia; Analgesics; Humans; Ketamine; Male; Pain; Pain Management; Wounds, Gunshot

2020
Ketamine for Acute Pain Management and Sedation.
    Critical care nurse, 2020, Oct-01, Volume: 40, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Analgesics; Conscious Sedation; Critical Care Nursing; Female; Human

2020
Emergency procedural sedation in children.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2020, Oct-05, Volume: 192, Issue:40

    Topics: Anesthetics, Dissociative; Antiemetics; Child; Contraindications, Drug; Emergency Service, Hospital;

2020
Anesthetic Management of a Complex Regional Pain Syndrome (CRPS) Patient With Ketamine.
    Anesthesia progress, 2020, 12-01, Volume: 67, Issue:4

    Topics: Anesthetics; Complex Regional Pain Syndromes; Humans; Ketamine; Pain; Reflex Sympathetic Dystrophy

2020
Patient-controlled analgesia in sickle-cell disease painful vaso-occlusive crises: should we add ketamine to morphine?
    Minerva anestesiologica, 2021, Volume: 87, Issue:10

    Topics: Analgesia, Patient-Controlled; Anemia, Sickle Cell; Humans; Ketamine; Morphine; Pain

2021
Population scale data reveals the antidepressant effects of ketamine and other therapeutics approved for non-psychiatric indications.
    Scientific reports, 2017, 05-03, Volume: 7, Issue:1

    Topics: Adverse Drug Reaction Reporting Systems; Analgesics; Anti-Bacterial Agents; Anti-Inflammatory Agents

2017
Intra-articular injections of ketamine and 25% dextrose improve clinical and pathological outcomes in the monosodium iodoacetate model of osteoarthritis.
    Journal of basic and clinical physiology and pharmacology, 2017, Nov-27, Volume: 28, Issue:6

    Topics: Animals; Arthritis, Experimental; Behavior, Animal; Drug Therapy, Combination; Glucose; Hyaluronic A

2017
Additive and antagonistic antinociceptive interactions between magnesium sulfate and ketamine in the rat formalin test.
    Acta neurobiologiae experimentalis, 2017, Volume: 77, Issue:2

    Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Formaldehyde; Ketamine; Magnesium Sulfate; Ma

2017
Why was a local anaesthetic used before administering intranasal ketamine for paediatric injuries?
    Acta paediatrica (Oslo, Norway : 1992), 2018, Volume: 107, Issue:1

    Topics: Analgesics; Anesthetics, Local; Child; Humans; Ketamine; Pain; Pain Management

2018
Patient characteristics affect the response to ketamine and opioids during the treatment of vaso-occlusive episode-related pain in sickle cell disease.
    Pediatric research, 2018, Volume: 83, Issue:2

    Topics: Adolescent; Analgesics, Opioid; Anemia, Sickle Cell; Child; Child, Preschool; Cohort Studies; Female

2018
[Comment on: ketamine for prevention of postoperative delirium and pain].
    Der Anaesthesist, 2017, Volume: 66, Issue:11

    Topics: Analgesics; Delirium; Humans; Ketamine; Pain; Pain, Postoperative; Postoperative Complications

2017
Additive and subadditive antiallodynic interactions between μ-opioid agonists and N-methyl D-aspartate antagonists in male rhesus monkeys.
    Behavioural pharmacology, 2018, Volume: 29, Issue:1

    Topics: Analgesics; Analgesics, Opioid; Animals; Conditioning, Operant; Dizocilpine Maleate; Dose-Response R

2018
The Involvement of the Endocannabinoid System in the Peripheral Antinociceptive Action of Ketamine.
    The journal of pain, 2018, Volume: 19, Issue:5

    Topics: Analgesics; Animals; Arachidonic Acids; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagoni

2018
Intravenous Ketamine Relieves Pain and Depression After Traumatic Suicide Attempts: A Case Series.
    Journal of clinical psychopharmacology, 2018, Volume: 38, Issue:2

    Topics: Administration, Intravenous; Aged; Aged, 80 and over; Analgesics; Antidepressive Agents; Depressive

2018
Ligustrazine Enhances the Hypnotic and Analgesic Effect of Ketamine in Mice.
    Biological & pharmaceutical bulletin, 2018, May-01, Volume: 41, Issue:5

    Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Drug Synergism; Hypnotics and Sedatives; Inje

2018
Ketamine as an Analgesic Adjuvant in Adult Trauma Intensive Care Unit Patients With Rib Fracture.
    The Annals of pharmacotherapy, 2018, Volume: 52, Issue:9

    Topics: Adjuvants, Pharmaceutic; Aged; Analgesics; Female; Humans; Infusions, Intravenous; Intensive Care Un

2018
Prospective follow-up of a cohort of preterm infants<33 WG receiving ketamine for tracheal intubation in the delivery room: Neurological outcome at 1 and 2 years.
    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 2018, Volume: 25, Issue:4

    Topics: Analgesics; Case-Control Studies; Child Development; Child, Preschool; Cohort Studies; Delivery Room

2018
Ketamine for military prehospital analgesia and sedation in combat casualties.
    Journal of the Royal Army Medical Corps, 2018, Volume: 164, Issue:6

    Topics: Accreditation; Analgesics; Capnography; Clinical Governance; Dose-Response Relationship, Drug; Emerg

2018
Continuous Intravenous Sub-Dissociative Dose Ketamine Infusion for Managing Pain in the Emergency Department.
    The western journal of emergency medicine, 2018, Volume: 19, Issue:3

    Topics: Administration, Intravenous; Analgesics; Emergency Service, Hospital; Female; Humans; Ketamine; Male

2018
Low-Dose Ketamine Infusion for Adjunct Management during Vaso-occlusive Episodes in Adults with Sickle Cell Disease: A Case Series.
    Journal of pain & palliative care pharmacotherapy, 2018, Volume: 32, Issue:1

    Topics: Adult; Analgesics; Analgesics, Opioid; Anemia, Sickle Cell; Dose-Response Relationship, Drug; Female

2018
Ketamine Use in the Intensive Care Unit.
    AACN advanced critical care, 2018,Summer, Volume: 29, Issue:2

    Topics: Adult; Analgesics; Critical Care; Curriculum; Education, Nursing, Continuing; Female; Humans; Ketami

2018
CE: Original Research: The Efficacy and Safety of an RN-Driven Ketamine Protocol for Adjunctive Analgesia During Burn Wound Care.
    The American journal of nursing, 2018, Volume: 118, Issue:7

    Topics: Adult; Analgesia; Analgesics; Analgesics, Opioid; Burns; Critical Care Nursing; Female; Fentanyl; Hu

2018
Brain Dynamics and Temporal Summation of Pain Predicts Neuropathic Pain Relief from Ketamine Infusion.
    Anesthesiology, 2018, Volume: 129, Issue:5

    Topics: Adult; Analgesics; Brain; Female; Humans; Infusions, Intravenous; Ketamine; Magnetic Resonance Imagi

2018
Case Report: Ketamine for Pain and Depression in Advanced Cancer.
    Journal of palliative medicine, 2018, Volume: 21, Issue:11

    Topics: Analgesics; Depression; Humans; Ketamine; Male; Middle Aged; Neoplasms; Pain; Treatment Outcome

2018
Ketamine stakes in 2018: Right doses, good choices.
    European journal of anaesthesiology, 2019, Volume: 36, Issue:1

    Topics: Bariatric Surgery; Double-Blind Method; Humans; Ketamine; Laparoscopy; Pain

2019
Targeting the affective component of pain with ketamine: A tool to improve the postoperative experience?
    European journal of anaesthesiology, 2019, Volume: 36, Issue:1

    Topics: Analgesics; Bariatric Surgery; Double-Blind Method; Humans; Ketamine; Laparoscopy; Pain

2019
Prehospital ketamine administration to pediatric trauma patients with head injuries in combat theaters.
    The American journal of emergency medicine, 2019, Volume: 37, Issue:8

    Topics: Adolescent; Analgesia; Child; Child, Preschool; Craniocerebral Trauma; Emergency Medical Services; F

2019
Letter to the Editor: Low-dose ketamine for pain control in patients with multiple rib fractures.
    The journal of trauma and acute care surgery, 2019, Volume: 87, Issue:4

    Topics: Adult; Humans; Ketamine; Pain; Pain Management; Rib Fractures; Spinal Fractures

2019
Authors' Reply to the Letter to the Editor from Mukhdomi and Kendall.
    European journal of pain (London, England), 2019, Volume: 23, Issue:6

    Topics: Analgesics, Opioid; Humans; Ketamine; Pain

2019
Evaluation of Tramadol-Midazolam-Ketamine Anaesthesia in Rabbits.
    Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria, 2018, Dec-30, Volume: 33, Issue:2

    Topics: Anesthetics; Animals; Body Temperature; Heart Rate; Ketamine; Midazolam; Pain; Rabbits; Tramadol; Xy

2018
Plasticity in the dynamic pain connectome associated with ketamine-induced neuropathic pain relief.
    Pain, 2019, Volume: 160, Issue:7

    Topics: Adult; Aged; Algorithms; Anesthetics, Dissociative; Connectome; Female; Gyrus Cinguli; Humans; Ketam

2019
Beyond Opioids for Pain Management in Adult Critically Ill Patients.
    Journal of pharmacy practice, 2019, Volume: 32, Issue:3

    Topics: Acetaminophen; Adrenergic alpha-2 Receptor Agonists; Adult; Analgesia; Analgesics; Analgesics, Non-N

2019
Comments on the paper by Nielsen et al. entitled "Intraoperative S-ketamine for the reduction of opioid consumption and pain one year after spine surgery: A randomized clinical trial of opioid-dependent patients".
    European journal of pain (London, England), 2019, Volume: 23, Issue:6

    Topics: Analgesics, Opioid; Humans; Ketamine; Pain

2019
Reply to Letter: Ketamine infusion for pain control in adult patients with multiple rib fractures.
    The journal of trauma and acute care surgery, 2019, Volume: 87, Issue:4

    Topics: Adult; Humans; Ketamine; Pain; Pain Management; Rib Fractures; Spinal Fractures

2019
Low-dose ketamine provides poor analgesia for pain in redback spider envenoming.
    British journal of clinical pharmacology, 2019, Volume: 85, Issue:10

    Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Female; Humans; Ketamine; Male; Middle Aged; Pain; Pilo

2019
Involvement of ATP-sensitive K(+) channels in the peripheral antinociceptive effect induced by ketamine.
    Veterinary anaesthesia and analgesia, 2013, Volume: 40, Issue:4

    Topics: Analgesics; Animals; Dose-Response Relationship, Drug; KATP Channels; Ketamine; Male; Pain; Pressure

2013
Effects of low-dose IV ketamine on peripheral and central pain from major limb injuries sustained in combat.
    Pain medicine (Malden, Mass.), 2013, Volume: 14, Issue:7

    Topics: Adolescent; Adult; Analgesics, Opioid; Excitatory Amino Acid Antagonists; Extremities; Humans; Infus

2013
Prehospital analgesia using nasal administration of S-ketamine--a case series.
    Scandinavian journal of trauma, resuscitation and emergency medicine, 2013, May-14, Volume: 21

    Topics: Administration, Intranasal; Adolescent; Analgesics; Child; Emergency Medical Services; Humans; Ketam

2013
Prehospital analgesia using nasal administration of S-ketamine--a case series.
    Scandinavian journal of trauma, resuscitation and emergency medicine, 2013, May-14, Volume: 21

    Topics: Administration, Intranasal; Adolescent; Analgesics; Child; Emergency Medical Services; Humans; Ketam

2013
Prehospital analgesia using nasal administration of S-ketamine--a case series.
    Scandinavian journal of trauma, resuscitation and emergency medicine, 2013, May-14, Volume: 21

    Topics: Administration, Intranasal; Adolescent; Analgesics; Child; Emergency Medical Services; Humans; Ketam

2013
Prehospital analgesia using nasal administration of S-ketamine--a case series.
    Scandinavian journal of trauma, resuscitation and emergency medicine, 2013, May-14, Volume: 21

    Topics: Administration, Intranasal; Adolescent; Analgesics; Child; Emergency Medical Services; Humans; Ketam

2013
Prehospital analgesia using nasal administration of S-ketamine--a case series.
    Scandinavian journal of trauma, resuscitation and emergency medicine, 2013, May-14, Volume: 21

    Topics: Administration, Intranasal; Adolescent; Analgesics; Child; Emergency Medical Services; Humans; Ketam

2013
Prehospital analgesia using nasal administration of S-ketamine--a case series.
    Scandinavian journal of trauma, resuscitation and emergency medicine, 2013, May-14, Volume: 21

    Topics: Administration, Intranasal; Adolescent; Analgesics; Child; Emergency Medical Services; Humans; Ketam

2013
Prehospital analgesia using nasal administration of S-ketamine--a case series.
    Scandinavian journal of trauma, resuscitation and emergency medicine, 2013, May-14, Volume: 21

    Topics: Administration, Intranasal; Adolescent; Analgesics; Child; Emergency Medical Services; Humans; Ketam

2013
Prehospital analgesia using nasal administration of S-ketamine--a case series.
    Scandinavian journal of trauma, resuscitation and emergency medicine, 2013, May-14, Volume: 21

    Topics: Administration, Intranasal; Adolescent; Analgesics; Child; Emergency Medical Services; Humans; Ketam

2013
Prehospital analgesia using nasal administration of S-ketamine--a case series.
    Scandinavian journal of trauma, resuscitation and emergency medicine, 2013, May-14, Volume: 21

    Topics: Administration, Intranasal; Adolescent; Analgesics; Child; Emergency Medical Services; Humans; Ketam

2013
The role of a low-dose ketamine-midazolam regimen in the management of severe painful crisis in patients with sickle cell disease.
    Journal of pain and symptom management, 2014, Volume: 47, Issue:2

    Topics: Administration, Intravenous; Adolescent; Adult; Analgesics; Analgesics, Opioid; Anemia, Sickle Cell;

2014
The role of a low-dose ketamine-midazolam regimen in the management of severe painful crisis in patients with sickle cell disease.
    Journal of pain and symptom management, 2014, Volume: 47, Issue:2

    Topics: Administration, Intravenous; Adolescent; Adult; Analgesics; Analgesics, Opioid; Anemia, Sickle Cell;

2014
The role of a low-dose ketamine-midazolam regimen in the management of severe painful crisis in patients with sickle cell disease.
    Journal of pain and symptom management, 2014, Volume: 47, Issue:2

    Topics: Administration, Intravenous; Adolescent; Adult; Analgesics; Analgesics, Opioid; Anemia, Sickle Cell;

2014
The role of a low-dose ketamine-midazolam regimen in the management of severe painful crisis in patients with sickle cell disease.
    Journal of pain and symptom management, 2014, Volume: 47, Issue:2

    Topics: Administration, Intravenous; Adolescent; Adult; Analgesics; Analgesics, Opioid; Anemia, Sickle Cell;

2014
[Effect of subanaesthetic dose of ketamine on mechanical stimulus on brain regions].
    Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae, 2013, Volume: 35, Issue:4

    Topics: Adult; Analgesics; Brain; Humans; Ketamine; Magnetic Resonance Imaging; Male; Pain; Pilot Projects

2013
Sickle cell pain management: are we missing the role of pronociception and neuropathic pain?
    Paediatric anaesthesia, 2013, Volume: 23, Issue:11

    Topics: Anemia, Sickle Cell; Anesthetics, Dissociative; Arterial Occlusive Diseases; Excitatory Amino Acid A

2013
Subanalgesic ketamine enhances morphine-induced antinociceptive activity without cortical dysfunction in rats.
    Journal of anesthesia, 2014, Volume: 28, Issue:3

    Topics: Analgesics; Animals; Cerebellar Cortex; Dose-Response Relationship, Drug; Ketamine; Male; Morphine;

2014
Ultra-low-dose ketamine infusion for ischemic limb pain.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2014, Volume: 61, Issue:1

    Topics: Adult; Analgesics; Dose-Response Relationship, Drug; Humans; Ischemia; Ketamine; Leg; Male; Pain; Tr

2014
Influence of clonidine and ketamine on m-RNA expression in a model of opioid-induced hyperalgesia in mice.
    PloS one, 2013, Volume: 8, Issue:11

    Topics: Analgesics, Opioid; Animals; Arrestins; beta-Arrestin 2; beta-Arrestins; Brain; Clonidine; Disease M

2013
[Ketamine-induced urinary symptoms].
    Ugeskrift for laeger, 2014, 02-03, Volume: 176, Issue:3

    Topics: Adult; Analgesics; Hallucinogens; Hematuria; Humans; Illicit Drugs; Ketamine; Lower Urinary Tract Sy

2014
Sub-dissociative-dose intranasal ketamine for moderate to severe pain in adult emergency department patients.
    Emergency medicine Australasia : EMA, 2014, Volume: 26, Issue:3

    Topics: Administration, Intranasal; Adult; Anesthetics, Dissociative; Dose-Response Relationship, Drug; Emer

2014
Sub-dissociative-dose intranasal ketamine for moderate to severe pain in adult emergency department patients.
    Emergency medicine Australasia : EMA, 2014, Volume: 26, Issue:3

    Topics: Administration, Intranasal; Adult; Anesthetics, Dissociative; Dose-Response Relationship, Drug; Emer

2014
Sub-dissociative-dose intranasal ketamine for moderate to severe pain in adult emergency department patients.
    Emergency medicine Australasia : EMA, 2014, Volume: 26, Issue:3

    Topics: Administration, Intranasal; Adult; Anesthetics, Dissociative; Dose-Response Relationship, Drug; Emer

2014
Sub-dissociative-dose intranasal ketamine for moderate to severe pain in adult emergency department patients.
    Emergency medicine Australasia : EMA, 2014, Volume: 26, Issue:3

    Topics: Administration, Intranasal; Adult; Anesthetics, Dissociative; Dose-Response Relationship, Drug; Emer

2014
Sub-dissociative-dose intranasal ketamine for moderate to severe pain in adult emergency department patients.
    Emergency medicine Australasia : EMA, 2014, Volume: 26, Issue:3

    Topics: Administration, Intranasal; Adult; Anesthetics, Dissociative; Dose-Response Relationship, Drug; Emer

2014
Sub-dissociative-dose intranasal ketamine for moderate to severe pain in adult emergency department patients.
    Emergency medicine Australasia : EMA, 2014, Volume: 26, Issue:3

    Topics: Administration, Intranasal; Adult; Anesthetics, Dissociative; Dose-Response Relationship, Drug; Emer

2014
Sub-dissociative-dose intranasal ketamine for moderate to severe pain in adult emergency department patients.
    Emergency medicine Australasia : EMA, 2014, Volume: 26, Issue:3

    Topics: Administration, Intranasal; Adult; Anesthetics, Dissociative; Dose-Response Relationship, Drug; Emer

2014
Sub-dissociative-dose intranasal ketamine for moderate to severe pain in adult emergency department patients.
    Emergency medicine Australasia : EMA, 2014, Volume: 26, Issue:3

    Topics: Administration, Intranasal; Adult; Anesthetics, Dissociative; Dose-Response Relationship, Drug; Emer

2014
Sub-dissociative-dose intranasal ketamine for moderate to severe pain in adult emergency department patients.
    Emergency medicine Australasia : EMA, 2014, Volume: 26, Issue:3

    Topics: Administration, Intranasal; Adult; Anesthetics, Dissociative; Dose-Response Relationship, Drug; Emer

2014
Sub-dissociative-dose intranasal ketamine for moderate to severe pain in adult emergency department patients.
    Emergency medicine Australasia : EMA, 2014, Volume: 26, Issue:3

    Topics: Administration, Intranasal; Adult; Anesthetics, Dissociative; Dose-Response Relationship, Drug; Emer

2014
Sub-dissociative-dose intranasal ketamine for moderate to severe pain in adult emergency department patients.
    Emergency medicine Australasia : EMA, 2014, Volume: 26, Issue:3

    Topics: Administration, Intranasal; Adult; Anesthetics, Dissociative; Dose-Response Relationship, Drug; Emer

2014
Sub-dissociative-dose intranasal ketamine for moderate to severe pain in adult emergency department patients.
    Emergency medicine Australasia : EMA, 2014, Volume: 26, Issue:3

    Topics: Administration, Intranasal; Adult; Anesthetics, Dissociative; Dose-Response Relationship, Drug; Emer

2014
Sub-dissociative-dose intranasal ketamine for moderate to severe pain in adult emergency department patients.
    Emergency medicine Australasia : EMA, 2014, Volume: 26, Issue:3

    Topics: Administration, Intranasal; Adult; Anesthetics, Dissociative; Dose-Response Relationship, Drug; Emer

2014
Sub-dissociative-dose intranasal ketamine for moderate to severe pain in adult emergency department patients.
    Emergency medicine Australasia : EMA, 2014, Volume: 26, Issue:3

    Topics: Administration, Intranasal; Adult; Anesthetics, Dissociative; Dose-Response Relationship, Drug; Emer

2014
Sub-dissociative-dose intranasal ketamine for moderate to severe pain in adult emergency department patients.
    Emergency medicine Australasia : EMA, 2014, Volume: 26, Issue:3

    Topics: Administration, Intranasal; Adult; Anesthetics, Dissociative; Dose-Response Relationship, Drug; Emer

2014
Sub-dissociative-dose intranasal ketamine for moderate to severe pain in adult emergency department patients.
    Emergency medicine Australasia : EMA, 2014, Volume: 26, Issue:3

    Topics: Administration, Intranasal; Adult; Anesthetics, Dissociative; Dose-Response Relationship, Drug; Emer

2014
Prehospital use of ketamine for analgesia and procedural sedation by critical care paramedics in the UK: a note of caution?
    Emergency medicine journal : EMJ, 2014, Volume: 31, Issue:12

    Topics: Allied Health Personnel; Analgesia; Conscious Sedation; Critical Care; Emergency Medical Services; H

2014
[Is it acceptable in 2014 that three-quarters of newborns are intubated without any sedation in the delivery room?].
    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 2014, Volume: 21, Issue:9

    Topics: Analgesics; Delivery Rooms; Delivery, Obstetric; Humans; Hypnotics and Sedatives; Infant, Newborn; I

2014
Psychiatric side effects of ketamine in hospitalized medical patients administered subanesthetic doses for pain control.
    Acta neuropsychiatrica, 2014, Volume: 26, Issue:4

    Topics: Adolescent; Adult; Aged; Analgesics; Female; Hospitalization; Humans; Ketamine; Male; Middle Aged; P

2014
Prepubertal gonadectomy in cats: different injectable anaesthetic combinations and comparison with gonadectomy at traditional age.
    Journal of feline medicine and surgery, 2015, Volume: 17, Issue:6

    Topics: Anesthesia; Anesthetics; Animals; Buprenorphine; Cats; Dexmedetomidine; Female; Injections, Intramus

2015
Ketamine coadministration attenuates morphine tolerance and leads to increased brain concentrations of both drugs in the rat.
    British journal of pharmacology, 2015, Volume: 172, Issue:11

    Topics: Analgesics; Analgesics, Opioid; Animals; Behavior, Animal; Brain; Chromatography, High Pressure Liqu

2015
Low-Dose Ketamine Infusion for Emergency Department Patients with Severe Pain.
    Pain medicine (Malden, Mass.), 2015, Volume: 16, Issue:7

    Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Blood Pressure; Dizziness; Dose-Response Relationship,

2015
Low-Dose Ketamine Infusion for Emergency Department Patients with Severe Pain.
    Pain medicine (Malden, Mass.), 2015, Volume: 16, Issue:7

    Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Blood Pressure; Dizziness; Dose-Response Relationship,

2015
Low-Dose Ketamine Infusion for Emergency Department Patients with Severe Pain.
    Pain medicine (Malden, Mass.), 2015, Volume: 16, Issue:7

    Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Blood Pressure; Dizziness; Dose-Response Relationship,

2015
Low-Dose Ketamine Infusion for Emergency Department Patients with Severe Pain.
    Pain medicine (Malden, Mass.), 2015, Volume: 16, Issue:7

    Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Blood Pressure; Dizziness; Dose-Response Relationship,

2015
Low-Dose Ketamine Infusion for Emergency Department Patients with Severe Pain.
    Pain medicine (Malden, Mass.), 2015, Volume: 16, Issue:7

    Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Blood Pressure; Dizziness; Dose-Response Relationship,

2015
Low-Dose Ketamine Infusion for Emergency Department Patients with Severe Pain.
    Pain medicine (Malden, Mass.), 2015, Volume: 16, Issue:7

    Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Blood Pressure; Dizziness; Dose-Response Relationship,

2015
Low-Dose Ketamine Infusion for Emergency Department Patients with Severe Pain.
    Pain medicine (Malden, Mass.), 2015, Volume: 16, Issue:7

    Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Blood Pressure; Dizziness; Dose-Response Relationship,

2015
Low-Dose Ketamine Infusion for Emergency Department Patients with Severe Pain.
    Pain medicine (Malden, Mass.), 2015, Volume: 16, Issue:7

    Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Blood Pressure; Dizziness; Dose-Response Relationship,

2015
Low-Dose Ketamine Infusion for Emergency Department Patients with Severe Pain.
    Pain medicine (Malden, Mass.), 2015, Volume: 16, Issue:7

    Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Blood Pressure; Dizziness; Dose-Response Relationship,

2015
Low-Dose Ketamine Infusion for Emergency Department Patients with Severe Pain.
    Pain medicine (Malden, Mass.), 2015, Volume: 16, Issue:7

    Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Blood Pressure; Dizziness; Dose-Response Relationship,

2015
Low-Dose Ketamine Infusion for Emergency Department Patients with Severe Pain.
    Pain medicine (Malden, Mass.), 2015, Volume: 16, Issue:7

    Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Blood Pressure; Dizziness; Dose-Response Relationship,

2015
Low-Dose Ketamine Infusion for Emergency Department Patients with Severe Pain.
    Pain medicine (Malden, Mass.), 2015, Volume: 16, Issue:7

    Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Blood Pressure; Dizziness; Dose-Response Relationship,

2015
Low-Dose Ketamine Infusion for Emergency Department Patients with Severe Pain.
    Pain medicine (Malden, Mass.), 2015, Volume: 16, Issue:7

    Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Blood Pressure; Dizziness; Dose-Response Relationship,

2015
Low-Dose Ketamine Infusion for Emergency Department Patients with Severe Pain.
    Pain medicine (Malden, Mass.), 2015, Volume: 16, Issue:7

    Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Blood Pressure; Dizziness; Dose-Response Relationship,

2015
Low-Dose Ketamine Infusion for Emergency Department Patients with Severe Pain.
    Pain medicine (Malden, Mass.), 2015, Volume: 16, Issue:7

    Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Blood Pressure; Dizziness; Dose-Response Relationship,

2015
Low-Dose Ketamine Infusion for Emergency Department Patients with Severe Pain.
    Pain medicine (Malden, Mass.), 2015, Volume: 16, Issue:7

    Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Blood Pressure; Dizziness; Dose-Response Relationship,

2015
The Efficacy and Safety of Procedural Sedoanalgesia with Midazolam and Ketamine in Pediatric Hematology.
    Turkish journal of haematology : official journal of Turkish Society of Haematology, 2015, Volume: 32, Issue:4

    Topics: Adolescent; Analgesia; Analgesics; Bone Marrow Examination; Child; Child, Preschool; Deep Sedation;

2015
Novel polymeric bioerodable microparticles for prolonged-release intrathecal delivery of analgesic agents for relief of intractable cancer-related pain.
    Journal of pharmaceutical sciences, 2015, Volume: 104, Issue:7

    Topics: Analgesics; Analgesics, Opioid; Animals; Delayed-Action Preparations; Ketamine; Lactic Acid; Male; M

2015
Low-Dose Ketamine in Chronic Critical Illness.
    Journal of intensive care medicine, 2016, Volume: 31, Issue:3

    Topics: Analgesics; Anxiety; Chronic Disease; Critical Care; Critical Illness; Dose-Response Relationship, D

2016
A synergistic interaction between magnesium sulphate and ketamine on the inhibition of acute nociception in rats.
    European review for medical and pharmacological sciences, 2015, Volume: 19, Issue:13

    Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Ke

2015
Comparison of two treatments with skewed ordinal responses.
    Statistics in medicine, 2016, Jan-30, Volume: 35, Issue:2

    Topics: Analgesics; Biostatistics; Computer Simulation; Humans; Ketamine; Logistic Models; Models, Statistic

2016
Evaluation of the Percutaneous Absorption of Ketamine HCl, Gabapentin, Clonidine HCl, and Baclofen, in Compounded Transdermal Pain Formulations, Using the Franz Finite Dose Model.
    Pain medicine (Malden, Mass.), 2016, Volume: 17, Issue:2

    Topics: Administration, Cutaneous; Aged; Amines; Baclofen; Clonidine; Cyclohexanecarboxylic Acids; Drug Comp

2016
Combination of paracetamol or ketamine with meperidine enhances antinociception.
    Human & experimental toxicology, 2016, Volume: 35, Issue:8

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Dose-Response Relationship, Dr

2016
Ketamine for pain management in France, an observational survey.
    Anaesthesia, critical care & pain medicine, 2015, Volume: 34, Issue:6

    Topics: Acute Pain; Aged; Anesthetics, Dissociative; Chronic Pain; Female; France; Health Care Surveys; Huma

2015
Pharmacological effects and toxicity of Costus pulverulentus C. Presl (Costaceae).
    Journal of ethnopharmacology, 2016, Mar-02, Volume: 180

    Topics: Acetic Acid; Analgesics; Anesthetics, Dissociative; Animals; Anti-Inflammatory Agents; Cell Line, Tu

2016
Effects of the noncompetitive N-methyl-d-aspartate receptor antagonists ketamine and MK-801 on pain-stimulated and pain-depressed behaviour in rats.
    European journal of pain (London, England), 2016, Volume: 20, Issue:8

    Topics: Animals; Behavior, Animal; Disease Models, Animal; Dizocilpine Maleate; Excitatory Amino Acid Antago

2016
Importance of Pharmacological Evaluation in the Treatment of Poststroke Pain by Spinal Cord Stimulation.
    Neuromodulation : journal of the International Neuromodulation Society, 2016, Volume: 19, Issue:7

    Topics: Adult; Aged; Analgesics; Female; Humans; Ketamine; Male; Middle Aged; Morphine; Pain; Pain Managemen

2016
A two-year retrospective review of the determinants of pre-hospital analgesia administration by alpine helicopter emergency medical physicians to patients with isolated limb injury.
    Anaesthesia, 2016, Volume: 71, Issue:7

    Topics: Adult; Air Ambulances; Analgesia; Analgesics; Analgesics, Opioid; Emergency Medical Services; Female

2016
[Safety and efficacy of ketamine for pain relief].
    Nederlands tijdschrift voor geneeskunde, 2016, Volume: 160

    Topics: Analgesics; Humans; Infusions, Intravenous; Ketamine; Pain; Pain Management

2016
The Role of Immunoglobulin E in the Pathogenesis of Ketamine Related Cystitis and Ulcerative Interstitial Cystitis: An Immunohistochemical Study.
    Pain physician, 2016, Volume: 19, Issue:4

    Topics: Adult; Aged; Biomarkers; Cystitis, Interstitial; Female; Humans; Immunoglobulin E; Ketamine; Male; M

2016
Will a Japanese Intravenous Ketamine-Resistant Patient Lose a Chance to Undergo the Spinal Cord Stimulation in the Future? Problems of Drug Challenge Test.
    Neuromodulation : journal of the International Neuromodulation Society, 2016, Volume: 19, Issue:5

    Topics: Analgesics; Humans; Japan; Ketamine; Pain; Pain Management; Pain Measurement; Spinal Cord Stimulatio

2016
Effectiveness of ketamine as an adjuvant to opioid-based therapy in decreasing pain associated with opioid tolerance in adults undergoing orthopedic surgery: a systematic review protocol.
    JBI database of systematic reviews and implementation reports, 2016, Volume: 14, Issue:10

    Topics: Adolescent; Adult; Aged; Analgesics; Analgesics, Opioid; Chemotherapy, Adjuvant; Drug Tolerance; Hum

2016
Pain management for chemotherapy-induced oral mucositis.
    Nursing children and young people, 2016, Dec-08, Volume: 28, Issue:10

    Topics: Administration, Intravenous; Analgesics; Analgesics, Opioid; Antineoplastic Agents; Cancer Pain; Chi

2016
Alternative analgesics: New drugs for pain seek to improve on ketamine's benefits.
    Nature medicine, 2017, 01-06, Volume: 23, Issue:1

    Topics: Analgesics, Non-Narcotic; Animals; Complex Regional Pain Syndromes; Drug Design; Fractures, Bone; Hu

2017
A Case Report: Subanesthetic Ketamine Infusion for Treatment of Cancer-Related Pain Produces Urinary Urge Incontinence.
    A & A case reports, 2017, May-01, Volume: 8, Issue:9

    Topics: Analgesics; Female; Humans; Infusions, Intravenous; Ketamine; Neoplasms; Pain; Pain Measurement; Uri

2017
Alterations in haemodynamic parameters during procedural sedation and analgesia in children: Is ketamine really to blame?
    Human & experimental toxicology, 2018, Volume: 37, Issue:1

    Topics: Analgesia; Anesthetics, Dissociative; Child; Emergency Service, Hospital; Hemodynamics; Humans; Hypn

2018
Interaction between morphine and norketamine enantiomers in rodent models of nociception.
    Pharmacology, biochemistry, and behavior, 2008, Volume: 90, Issue:4

    Topics: Analgesics, Opioid; Animals; Constriction, Pathologic; Dose-Response Relationship, Drug; Drug Combin

2008
Effects of norketamine enantiomers in rodent models of persistent pain.
    Pharmacology, biochemistry, and behavior, 2008, Volume: 90, Issue:4

    Topics: Animals; Behavior, Animal; Chronic Disease; Constriction, Pathologic; Dose-Response Relationship, Dr

2008
Plasma levels of a low-dose constant-rate-infusion of ketamine and its effect on single and repeated nociceptive stimuli in conscious dogs.
    Veterinary journal (London, England : 1997), 2009, Volume: 182, Issue:2

    Topics: Anesthetics, Dissociative; Animals; Dogs; Dose-Response Relationship, Drug; Electromyography; Infusi

2009
An intravenous ketamine test as a predictive response tool in opioid-exposed patients with persistent pain.
    Journal of pain and symptom management, 2009, Volume: 37, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Anesthetics, Dissociative; Chronic Disease; Fema

2009
Haloperidol and risperidone have specific effects on altered pain sensitivity in the ketamine model of schizophrenia.
    Psychopharmacology, 2009, Volume: 202, Issue:4

    Topics: Analgesics, Opioid; Animals; Antipsychotic Agents; Dose-Response Relationship, Drug; Electric Stimul

2009
Prevention of N-methyl-D-aspartate-induced mechanical nociception by intrathecal administration of ketoprofen and ketamine in sheep.
    Anesthesia and analgesia, 2008, Volume: 107, Issue:6

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Female; Injections, Spinal; Ketamine; Ketoprofen;

2008
Adding midazolam to ketamine in the pediatric emergency department--it doesn't add up.
    Indian pediatrics, 2008, Volume: 45, Issue:11

    Topics: Anesthetics, Dissociative; Anesthetics, Intravenous; Drug Therapy, Combination; Emergency Medical Se

2008
European pain management discussion forum.
    Journal of pain & palliative care pharmacotherapy, 2008, Volume: 22, Issue:2

    Topics: Analgesics; Analgesics, Opioid; Botulinum Toxins, Type A; Drug Tolerance; Humans; Ketamine; Neuromus

2008
Effective use of topical amitriptyline hydrochloride 2.5% and ketamine hydrochloride 0.5% for analgesia in refractory proctodynia.
    Journal of drugs in dermatology : JDD, 2008, Volume: 7, Issue:9

    Topics: Administration, Topical; Amitriptyline; Anal Canal; Analgesics; Drug Combinations; Humans; Ketamine;

2008
Dreaming of patients' satisfaction.
    Minerva anestesiologica, 2009, Volume: 75, Issue:6

    Topics: Anesthetics, Dissociative; Humans; Ketamine; Pain; Pain Measurement; Pain, Postoperative; Patient Sa

2009
Pharmacokinetics of ketamine and its metabolite norketamine administered at a sub-anesthetic dose together with xylazine to calves prior to castration.
    Journal of veterinary pharmacology and therapeutics, 2009, Volume: 32, Issue:2

    Topics: Adrenergic alpha-Agonists; Anesthesia, Intravenous; Anesthetics, Dissociative; Animals; Cattle; Chro

2009
Antinociceptive effect of the cannabinoid agonist, WIN 55,212-2, in the orofacial and temporomandibular formalin tests.
    European journal of pain (London, England), 2010, Volume: 14, Issue:1

    Topics: Analgesics; Analgesics, Opioid; Anesthetics, Dissociative; Animals; Anti-Inflammatory Agents, Non-St

2010
Inhibiting astrocytic activation: a novel analgesic mechanism of ketamine at the spinal level?
    Journal of neurochemistry, 2009, Volume: 109, Issue:6

    Topics: Analgesics; Anesthesia; Animals; Astrocytes; Disease Models, Animal; Drug Administration Routes; Gli

2009
Propofol/alfentanil and propofol/ketamine procedural sedation in children with acute lymphoblastic leukaemia: safety, efficacy and their correlation with pain neuromediator expression.
    European journal of cancer care, 2010, Volume: 19, Issue:2

    Topics: Adolescent; Alfentanil; Anxiety; Child; Child, Preschool; Conscious Sedation; Cross-Over Studies; Dr

2010
An observational study on the effect of S+-ketamine on chronic pain versus experimental acute pain in Complex Regional Pain Syndrome type 1 patients.
    European journal of pain (London, England), 2010, Volume: 14, Issue:3

    Topics: Acute Disease; Adult; Analgesics; Analysis of Variance; Chronic Disease; Dose-Response Relationship,

2010
Ketamine and chronic pain--going the distance.
    Pain, 2009, Volume: 145, Issue:3

    Topics: Anesthetics, Dissociative; Chronic Disease; Humans; Ketamine; Pain

2009
Ketamine and midazolam in combination.
    The Clinical journal of pain, 2009, Volume: 25, Issue:4

    Topics: Adolescent; Adult; Aged; Analgesia, Patient-Controlled; Analgesics; Bandages; Burns; Drug Therapy, C

2009
Can ketamine prescribed for pain cause damage to the urinary tract?
    Palliative medicine, 2009, Volume: 23, Issue:7

    Topics: Adult; Aged; Analgesics; Fatal Outcome; Female; Humans; Ketamine; Male; Middle Aged; Pain; Palliativ

2009
Preventing pain on injection of propofol: a comparison between peripheral ketamine pre-treatment and ketamine added to propofol.
    Anaesthesia and intensive care, 2009, Volume: 37, Issue:4

    Topics: Adult; Anesthetics, Intravenous; Female; Humans; Injections, Intravenous; Ketamine; Male; Middle Age

2009
Opioid switching and burst ketamine to improve the opioid response in patients with movement-related pain due to bone metastases.
    The Clinical journal of pain, 2009, Volume: 25, Issue:7

    Topics: Analgesics, Opioid; Anesthetics, Dissociative; Bone Neoplasms; Humans; Ketamine; Male; Middle Aged;

2009
Ketamine mouthwash for mucositis pain.
    Journal of palliative medicine, 2009, Volume: 12, Issue:11

    Topics: Analgesics; Humans; Ketamine; Medical Audit; Mouthwashes; Mucositis; Pain; Retrospective Studies

2009
S(+)-ketamine effect on experimental pain and cardiac output: a population pharmacokinetic-pharmacodynamic modeling study in healthy volunteers.
    Anesthesiology, 2009, Volume: 111, Issue:4

    Topics: Adolescent; Adult; Algorithms; Anesthetics, Dissociative; Cardiac Output; Dose-Response Relationship

2009
[Sedation using ketamine for pain procedures in Pediatric Oncology.].
    Bulletin du cancer, 2009, Sep-01, Volume: 96 Suppl 2

    Topics: Child; Drug Therapy, Combination; Humans; Hypnotics and Sedatives; Ketamine; Midazolam; Pain

2009
Mechanisms and treatment of neuropathic pain.
    Central nervous system agents in medicinal chemistry, 2009, Volume: 9, Issue:1

    Topics: Afferent Pathways; Analgesics; Antidepressive Agents; Antidepressive Agents, Tricyclic; Clinical Tri

2009
Use of low-dose ketamine infusion for pediatric patients with sickle cell disease-related pain: a case series.
    The Clinical journal of pain, 2010, Volume: 26, Issue:2

    Topics: Adolescent; Analgesics; Anemia, Sickle Cell; Child; Dose-Response Relationship, Drug; Female; Humans

2010
Use of low-dose ketamine infusion for pediatric patients with sickle cell disease-related pain: a case series.
    The Clinical journal of pain, 2010, Volume: 26, Issue:2

    Topics: Adolescent; Analgesics; Anemia, Sickle Cell; Child; Dose-Response Relationship, Drug; Female; Humans

2010
Use of low-dose ketamine infusion for pediatric patients with sickle cell disease-related pain: a case series.
    The Clinical journal of pain, 2010, Volume: 26, Issue:2

    Topics: Adolescent; Analgesics; Anemia, Sickle Cell; Child; Dose-Response Relationship, Drug; Female; Humans

2010
Use of low-dose ketamine infusion for pediatric patients with sickle cell disease-related pain: a case series.
    The Clinical journal of pain, 2010, Volume: 26, Issue:2

    Topics: Adolescent; Analgesics; Anemia, Sickle Cell; Child; Dose-Response Relationship, Drug; Female; Humans

2010
Total procedural requirements as indication for emergency department sedation.
    Pediatric emergency care, 2010, Volume: 26, Issue:3

    Topics: Analgesics; Anesthetics, Dissociative; Conscious Sedation; Emergency Service, Hospital; Female; Huma

2010
Human experimental pain models 3: heat/capsaicin sensitization and intradermal capsaicin models.
    Methods in molecular biology (Clifton, N.J.), 2010, Volume: 617

    Topics: Alfentanil; Analgesics, Opioid; Capsaicin; Hot Temperature; Humans; Hyperalgesia; Injections, Intrad

2010
Upper gastrointestinal problems in inhalational ketamine abusers.
    Journal of digestive diseases, 2010, Volume: 11, Issue:2

    Topics: Administration, Inhalation; Adult; Analgesics; China; Cohort Studies; Female; Gastritis; Humans; Inc

2010
Management of cancer pain: ESMO Clinical Practice Guidelines.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2010, Volume: 21 Suppl 5

    Topics: Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; D

2010
Ketamine for managing perioperative pain in opioid-dependent patients with chronic pain: a unique indication?
    Anesthesiology, 2010, Volume: 113, Issue:3

    Topics: Chronic Disease; Disease Management; Humans; Ketamine; Opioid-Related Disorders; Pain; Pain, Postope

2010
Taming the ketamine tiger. 1965.
    Anesthesiology, 2010, Volume: 113, Issue:3

    Topics: Analgesics; Animals; Behavior, Addictive; Hallucinogens; History, 20th Century; Humans; Ketamine; Pa

2010
The addition of ketamine to a morphine nurse- or patient-controlled analgesia infusion (PCA/NCA) increases analgesic efficacy in children with mucositis pain.
    Paediatric anaesthesia, 2010, Volume: 20, Issue:9

    Topics: Adolescent; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, Dissociative; Child; Chi

2010
Low-dose ketamine for analgesia in the ED: a retrospective case series.
    The American journal of emergency medicine, 2010, Volume: 28, Issue:7

    Topics: Adult; Analgesia; Analgesics; Emergency Service, Hospital; Emergency Treatment; Female; Health Care

2010
Low-dose ketamine for analgesia in the ED: a retrospective case series.
    The American journal of emergency medicine, 2010, Volume: 28, Issue:7

    Topics: Adult; Analgesia; Analgesics; Emergency Service, Hospital; Emergency Treatment; Female; Health Care

2010
Low-dose ketamine for analgesia in the ED: a retrospective case series.
    The American journal of emergency medicine, 2010, Volume: 28, Issue:7

    Topics: Adult; Analgesia; Analgesics; Emergency Service, Hospital; Emergency Treatment; Female; Health Care

2010
Low-dose ketamine for analgesia in the ED: a retrospective case series.
    The American journal of emergency medicine, 2010, Volume: 28, Issue:7

    Topics: Adult; Analgesia; Analgesics; Emergency Service, Hospital; Emergency Treatment; Female; Health Care

2010
Low-dose ketamine for analgesia in the ED: a retrospective case series.
    The American journal of emergency medicine, 2010, Volume: 28, Issue:7

    Topics: Adult; Analgesia; Analgesics; Emergency Service, Hospital; Emergency Treatment; Female; Health Care

2010
Low-dose ketamine for analgesia in the ED: a retrospective case series.
    The American journal of emergency medicine, 2010, Volume: 28, Issue:7

    Topics: Adult; Analgesia; Analgesics; Emergency Service, Hospital; Emergency Treatment; Female; Health Care

2010
Low-dose ketamine for analgesia in the ED: a retrospective case series.
    The American journal of emergency medicine, 2010, Volume: 28, Issue:7

    Topics: Adult; Analgesia; Analgesics; Emergency Service, Hospital; Emergency Treatment; Female; Health Care

2010
Low-dose ketamine for analgesia in the ED: a retrospective case series.
    The American journal of emergency medicine, 2010, Volume: 28, Issue:7

    Topics: Adult; Analgesia; Analgesics; Emergency Service, Hospital; Emergency Treatment; Female; Health Care

2010
Low-dose ketamine for analgesia in the ED: a retrospective case series.
    The American journal of emergency medicine, 2010, Volume: 28, Issue:7

    Topics: Adult; Analgesia; Analgesics; Emergency Service, Hospital; Emergency Treatment; Female; Health Care

2010
Low-dose ketamine for analgesia in the ED: a retrospective case series.
    The American journal of emergency medicine, 2010, Volume: 28, Issue:7

    Topics: Adult; Analgesia; Analgesics; Emergency Service, Hospital; Emergency Treatment; Female; Health Care

2010
Low-dose ketamine for analgesia in the ED: a retrospective case series.
    The American journal of emergency medicine, 2010, Volume: 28, Issue:7

    Topics: Adult; Analgesia; Analgesics; Emergency Service, Hospital; Emergency Treatment; Female; Health Care

2010
Low-dose ketamine for analgesia in the ED: a retrospective case series.
    The American journal of emergency medicine, 2010, Volume: 28, Issue:7

    Topics: Adult; Analgesia; Analgesics; Emergency Service, Hospital; Emergency Treatment; Female; Health Care

2010
Low-dose ketamine for analgesia in the ED: a retrospective case series.
    The American journal of emergency medicine, 2010, Volume: 28, Issue:7

    Topics: Adult; Analgesia; Analgesics; Emergency Service, Hospital; Emergency Treatment; Female; Health Care

2010
Low-dose ketamine for analgesia in the ED: a retrospective case series.
    The American journal of emergency medicine, 2010, Volume: 28, Issue:7

    Topics: Adult; Analgesia; Analgesics; Emergency Service, Hospital; Emergency Treatment; Female; Health Care

2010
Low-dose ketamine for analgesia in the ED: a retrospective case series.
    The American journal of emergency medicine, 2010, Volume: 28, Issue:7

    Topics: Adult; Analgesia; Analgesics; Emergency Service, Hospital; Emergency Treatment; Female; Health Care

2010
Low-dose ketamine for analgesia in the ED: a retrospective case series.
    The American journal of emergency medicine, 2010, Volume: 28, Issue:7

    Topics: Adult; Analgesia; Analgesics; Emergency Service, Hospital; Emergency Treatment; Female; Health Care

2010
Achieving prehospital analgesia.
    Emergency medicine journal : EMJ, 2012, Volume: 29, Issue:9

    Topics: Accidents, Traffic; Adult; Analgesics; Emergency Medical Services; Femoral Fractures; Humans; Ketami

2012
Morphine exposure in early life increases nociceptive behavior in a rat formalin tonic pain model in adult life.
    Brain research, 2011, Jan-07, Volume: 1367

    Topics: Age Factors; Analgesics, Opioid; Analysis of Variance; Anesthetics, Dissociative; Animals; Animals,

2011
Effect of sub-anesthetic xylazine and ketamine ('ketamine stun') administered to calves immediately prior to castration.
    Veterinary anaesthesia and analgesia, 2010, Volume: 37, Issue:6

    Topics: Anesthesia, Intravenous; Anesthetics, Dissociative; Animals; Cattle; Dose-Response Relationship, Dru

2010
Low-dose ketamine for analgesia in the ED: a retrospective case series.
    The American journal of emergency medicine, 2011, Volume: 29, Issue:3

    Topics: Analgesics; Emergency Service, Hospital; Humans; Ketamine; Pain; Retrospective Studies

2011
Pain management in 100 episodes of severe mucositis in children.
    Paediatric anaesthesia, 2011, Volume: 21, Issue:4

    Topics: Adolescent; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, Dissociative; Child; Dru

2011
Exploring the pharmacokinetics of oral ketamine in children undergoing burns procedures.
    Paediatric anaesthesia, 2011, Volume: 21, Issue:6

    Topics: Administration, Oral; Anesthetics, Dissociative; Biological Availability; Biotransformation; Burns;

2011
[Effect of intrathecal ketamine injection on protein kinase C expression in the spinal dorsal horn of rats with formalin-induced pain].
    Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2011, Volume: 31, Issue:3

    Topics: Animals; Formaldehyde; Injections, Spinal; Ketamine; Male; Pain; Pain Measurement; Posterior Horn Ce

2011
Combining ketamine and virtual reality pain control during severe burn wound care: one military and one civilian patient.
    Pain medicine (Malden, Mass.), 2011, Volume: 12, Issue:4

    Topics: Adult; Analgesia; Analgesics; Burns; Computer Simulation; Debridement; Humans; Ketamine; Male; Milit

2011
The effect of target-controlled infusion of low-dose ketamine on heat pain and temporal summation threshold.
    Journal of anesthesia, 2011, Volume: 25, Issue:4

    Topics: Adult; Anesthetics, Dissociative; Electric Stimulation; Female; Hot Temperature; Humans; Infusion Pu

2011
Nonselective and NR2B-selective N-methyl-D-aspartic acid receptor antagonists produce antinociception and long-term relief of allodynia in acute and neuropathic pain.
    Anesthesiology, 2011, Volume: 115, Issue:1

    Topics: Acute Disease; Analgesics; Animals; Chronic Disease; Cold Temperature; Data Interpretation, Statisti

2011
Successful reversal of hyperalgesia/myoclonus complex with low-dose ketamine infusion.
    Pain practice : the official journal of World Institute of Pain, 2012, Volume: 12, Issue:2

    Topics: Analgesics, Opioid; Humans; Hydromorphone; Hyperalgesia; Infusions, Intravenous; Ketamine; Male; Mid

2012
Ketamine activates the L-arginine/Nitric oxide/cyclic guanosine monophosphate pathway to induce peripheral antinociception in rats.
    Anesthesia and analgesia, 2011, Volume: 113, Issue:5

    Topics: Analgesia; Anesthetics, Dissociative; Animals; Arginine; Cyclic AMP; Dinoprostone; Drug Synergism; E

2011
Ketamine infusion for sickle cell crisis pain in an adult.
    Journal of pain and symptom management, 2011, Volume: 42, Issue:3

    Topics: Adult; Analgesics; Anemia, Sickle Cell; Humans; Ketamine; Male; Pain; Pain Measurement; Treatment Ou

2011
[Cystitis and ketamine associated bladder dysfunction].
    Actas urologicas espanolas, 2012, Volume: 36, Issue:1

    Topics: Adolescent; Adult; Cross-Sectional Studies; Cystitis; Dose-Response Relationship, Drug; Excitatory A

2012
Arresting the development of morphine tolerance and dependence.
    British journal of anaesthesia, 2011, Volume: 107, Issue:5

    Topics: Analgesics; Animals; Drug Tolerance; Humans; Ketamine; Morphine Dependence; Naltrexone; Narcotic Ant

2011
Synthesis and study the analgesic effects of new analogues of ketamine on female wistar rats.
    Medicinal chemistry (Shariqah (United Arab Emirates)), 2012, Volume: 8, Issue:2

    Topics: Analgesics; Animals; Female; Formaldehyde; Ketamine; Molecular Structure; Pain; Rats; Rats, Wistar

2012
Epidural ketamine in the dromedary camel.
    Veterinary anaesthesia and analgesia, 2012, Volume: 39, Issue:3

    Topics: Analgesics; Anesthesia, Epidural; Animals; Dose-Response Relationship, Drug; Ketamine; Male; Pain

2012
Mood and pain responses to repeat dose intramuscular ketamine in a depressed patient with advanced cancer.
    Journal of palliative medicine, 2012, Volume: 15, Issue:4

    Topics: Adult; Anesthetics, Dissociative; Depressive Disorder, Major; Disease Progression; Dysthymic Disorde

2012
[Low dose ketamine for pediatric procedure-related pain].
    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 2012, Volume: 19, Issue:7

    Topics: Analgesics; Child; Humans; Ketamine; Pain; Pain Management; Pediatrics; Practice Guidelines as Topic

2012
Noxious stimulation attenuates ketamine-induced neuroapoptosis in the developing rat brain.
    Anesthesiology, 2012, Volume: 117, Issue:1

    Topics: Animals; Apoptosis; Brain; Caspase 3; Cyclin D1; Freund's Adjuvant; Glycogen Synthase Kinase 3; Glyc

2012
Impact of general injection anaesthesia and analgesia on post-castration behaviour and teat order of piglets.
    Animal : an international journal of animal bioscience, 2012, Volume: 6, Issue:12

    Topics: Anesthetics, General; Animal Welfare; Animals; Animals, Newborn; Animals, Suckling; Anti-Inflammator

2012
Low-dose ketamine analgesia: patient and physician experience in the ED.
    The American journal of emergency medicine, 2013, Volume: 31, Issue:2

    Topics: Adult; Analgesics; Attitude of Health Personnel; Conscious Sedation; Emergency Service, Hospital; Fe

2013
Low-dose ketamine analgesia: patient and physician experience in the ED.
    The American journal of emergency medicine, 2013, Volume: 31, Issue:2

    Topics: Adult; Analgesics; Attitude of Health Personnel; Conscious Sedation; Emergency Service, Hospital; Fe

2013
Low-dose ketamine analgesia: patient and physician experience in the ED.
    The American journal of emergency medicine, 2013, Volume: 31, Issue:2

    Topics: Adult; Analgesics; Attitude of Health Personnel; Conscious Sedation; Emergency Service, Hospital; Fe

2013
Low-dose ketamine analgesia: patient and physician experience in the ED.
    The American journal of emergency medicine, 2013, Volume: 31, Issue:2

    Topics: Adult; Analgesics; Attitude of Health Personnel; Conscious Sedation; Emergency Service, Hospital; Fe

2013
Emerging applications of low-dose ketamine for pain management in the ED.
    The American journal of emergency medicine, 2013, Volume: 31, Issue:2

    Topics: Adult; Analgesics; Emergency Service, Hospital; Female; Humans; Ketamine; Male; Middle Aged; Pain

2013
Effects of propofol, sevoflurane, remifentanil, and (S)-ketamine in subanesthetic concentrations on visceral and somatosensory pain-evoked potentials.
    Anesthesiology, 2013, Volume: 118, Issue:2

    Topics: Adult; Analgesics, Opioid; Anesthetics, Dissociative; Anesthetics, Inhalation; Anesthetics, Intraven

2013
Involvement of N-methyl-D-aspartate receptors in nociception in the cyclophosphamide-induced vesical pain model in the conscious rat.
    European journal of pain (London, England), 2002, Volume: 6, Issue:4

    Topics: Acrolein; Animals; Antineoplastic Agents, Alkylating; Behavior, Animal; Cyclophosphamide; Cystitis;

2002
Successful use of oral methadone after failure of intravenous morphine and ketamine.
    Anaesthesia and intensive care, 2002, Volume: 30, Issue:4

    Topics: Acute Disease; Administration, Oral; Adult; Analgesia, Patient-Controlled; Analgesics; Analgesics, O

2002
Analgesia with ketamine in a patient with perioperative opioid tolerance.
    Journal of pain and symptom management, 2002, Volume: 24, Issue:1

    Topics: Analgesics; Analgesics, Opioid; Drug Tolerance; Humans; Ketamine; Laparotomy; Pain

2002
Modulation of formalin-induced behaviors and edema by local and systemic administration of dextromethorphan, memantine and ketamine.
    European journal of pharmacology, 2002, Aug-23, Volume: 450, Issue:2

    Topics: Animals; Behavior, Animal; Dextromethorphan; Dose-Response Relationship, Drug; Edema; Excitatory Ami

2002
Dextromethorphan and ketamine potentiate the antinociceptive effects of mu- but not delta- or kappa-opioid agonists in a mouse model of acute pain.
    Pharmacology, biochemistry, and behavior, 2002, Volume: 74, Issue:1

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics

2002
Venous malformations associated with central pain: report of a case.
    Anesthesia and analgesia, 2002, Volume: 95, Issue:5

    Topics: Analgesics, Opioid; Dextromethorphan; Excitatory Amino Acid Antagonists; Female; Humans; Intracrania

2002
Large-amplitude 5-HT1A receptor activation: a new mechanism of profound, central analgesia.
    Neuropharmacology, 2002, Volume: 43, Issue:6

    Topics: Acetates; Adrenergic Uptake Inhibitors; Amines; Aminopyridines; Analgesia; Analgesics; Animals; Cell

2002
Interactions of NMDA antagonists and an alpha 2 agonist with mu, delta and kappa opioids in an acute nociception assay.
    Acta anaesthesiologica Belgica, 2002, Volume: 53, Issue:3

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenergic

2002
Antinociceptive effect in mice of intraperitoneal N-methyl-D-aspartate receptor antagonists in the formalin test.
    European journal of pain (London, England), 2003, Volume: 7, Issue:2

    Topics: Animals; Behavior, Animal; Dextromethorphan; Dizocilpine Maleate; Dose-Response Relationship, Drug;

2003
Peripheral interactions between dextromethorphan, ketamine and amitriptyline on formalin-evoked behaviors and paw edema in rats.
    Pain, 2003, Volume: 102, Issue:1-2

    Topics: Amitriptyline; Analgesics, Non-Narcotic; Animals; Behavior, Animal; Dextromethorphan; Dose-Response

2003
Reticular thalamic responses to nociceptive inputs in anesthetized rats.
    Brain research, 2003, Apr-11, Volume: 968, Issue:2

    Topics: Action Potentials; Afferent Pathways; Anesthesia; Anesthetics, Dissociative; Anesthetics, Inhalation

2003
Burst ketamine to reverse opioid tolerance in cancer pain.
    Journal of pain and symptom management, 2003, Volume: 25, Issue:4

    Topics: Aged; Analgesics, Opioid; Drug Tolerance; Excitatory Amino Acid Antagonists; Female; Humans; Ketamin

2003
A retrospective comparison of the dose ratio between subcutaneous and oral ketamine.
    Journal of pain and symptom management, 2003, Volume: 25, Issue:5

    Topics: Administration, Oral; Adult; Analgesics; Dose-Response Relationship, Drug; Humans; Infusions, Intrav

2003
Topical capsaicin-induced allodynia in unanesthetized primates: pharmacological modulation.
    The Journal of pharmacology and experimental therapeutics, 2003, Volume: 306, Issue:3

    Topics: Aminobutyrates; Analgesics; Animals; Benzeneacetamides; Capsaicin; Disease Models, Animal; Dizocilpi

2003
Pharmacological modulation of experimental phasic and tonic muscle pain by morphine, alfentanil and ketamine in healthy volunteers.
    Acta anaesthesiologica Scandinavica, 2003, Volume: 47, Issue:8

    Topics: Adult; Alfentanil; Electric Stimulation; Female; Humans; Ketamine; Male; Morphine; Muscle, Skeletal;

2003
Effect of long-term ketamine administration on vocalization to paw pressure and on spinal wind-up activity in monoarthritic rats.
    The International journal of neuroscience, 2003, Volume: 113, Issue:9

    Topics: Analgesics; Analysis of Variance; Animals; Arthritis, Experimental; Arthritis, Infectious; Chronic D

2003
Ketamine to control pain.
    Journal of palliative medicine, 2003, Volume: 6, Issue:3

    Topics: Adult; Analgesics; Fatal Outcome; Female; Humans; Infusions, Intravenous; Ketamine; Neoplasms; Pain

2003
Ketamine in the management of chronic pancreatic pain.
    Journal of pain and symptom management, 2003, Volume: 26, Issue:6

    Topics: Aged; Analgesics; Chronic Disease; Humans; Ketamine; Male; Pain; Pancreatitis

2003
C-fos expression in rat brain nuclei following incisor tooth movement.
    Journal of dental research, 2004, Volume: 83, Issue:1

    Topics: Analgesics; Animals; Brain; Genes, fos; Incisor; Ketamine; Locus Coeruleus; Male; Models, Animal; Ne

2004
Evaluation of the use of anesthesia and analgesia in reptiles.
    Journal of the American Veterinary Medical Association, 2004, Feb-15, Volume: 224, Issue:4

    Topics: Analgesia; Analgesics; Anesthesia; Anesthetics, Inhalation; Animals; Butorphanol; Humans; Hypothermi

2004
Effects of anesthesia and nociceptive stimulation in an experimental model of brachial plexus avulsion.
    Physiological research, 2004, Volume: 53, Issue:2

    Topics: Anesthesia; Animals; Brachial Plexus; Ketamine; Male; Models, Animal; Nociceptors; Pain; Pentobarbit

2004
Effects of ketamine anesthesia on central nociceptive processing in the rat: a 2-deoxyglucose study.
    Neuroscience, 2004, Volume: 125, Issue:2

    Topics: Analysis of Variance; Anesthesia; Anesthetics, Dissociative; Animals; Behavior, Animal; Blood Glucos

2004
Ketamine to reduce propofol injection pain.
    Paediatric anaesthesia, 2004, Volume: 14, Issue:7

    Topics: Anesthetics, Intravenous; Anesthetics, Local; Child; Clinical Trials as Topic; Drug Combinations; Dr

2004
Subanesthetic ketamine: an essential adjuvant for intractable cancer pain.
    Journal of pain and symptom management, 2004, Volume: 28, Issue:2

    Topics: Adult; Analgesics; Anesthetics, Dissociative; Chemotherapy, Adjuvant; Female; Femoral Neoplasms; Hum

2004
Intraarticular pretreatment with ketamine and memantine could prevent arthritic pain: relevance to the decrease of spinal c-fos expression in rats.
    Anesthesia and analgesia, 2004, Volume: 99, Issue:1

    Topics: Animals; Arthritis, Experimental; Behavior, Animal; Body Weight; Carrageenan; Excitatory Amino Acid

2004
Safety and efficacy of intranasal ketamine in a mixed population with chronic pain.
    Pain, 2004, Volume: 110, Issue:3

    Topics: Administration, Intranasal; Chronic Disease; Clinical Trials as Topic; Humans; Ketamine; Pain

2004
Comment on: Bell RF, Kalso K. Is intranasal ketamine an appropriate treatment for chronic non-cancer breakthrough pain? Pain 2004;108:1-2.
    Pain, 2004, Volume: 110, Issue:3

    Topics: Administration, Intranasal; Chronic Disease; Humans; Ketamine; Pain

2004
Ketamine potentiates the effect of electroacupuncture on mechanical allodynia in a rat model of neuropathic pain.
    Neuroscience letters, 2004, Sep-30, Volume: 368, Issue:3

    Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Electroacupuncture; Female; Ketam

2004
[Case of radial nerve injury induced by withdrawing a catheter from the cephalic vein].
    Masui. The Japanese journal of anesthesiology, 2004, Volume: 53, Issue:9

    Topics: Adult; Arm; Brachiocephalic Veins; Catheterization, Peripheral; Catheters, Indwelling; Education, Me

2004
Differences between primary somatosensory cortex- and vertex-derived somatosensory-evoked potentials in the rat.
    Brain research, 2004, Dec-31, Volume: 1030, Issue:2

    Topics: Anesthetics; Animals; Brain Mapping; Cerebral Cortex; Electric Stimulation; Evoked Potentials, Somat

2004
Pain on injection of rocuronium: influence of ketamine pretreatment.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2005, Volume: 52, Issue:1

    Topics: Androstanols; Anesthetics, Dissociative; Humans; Injections; Intraoperative Complications; Ketamine;

2005
Pre-versus post-formalin effects of intrathecal ketamine on spinal Fos-like immunoreactivity in rats.
    The Indian journal of medical research, 2004, Volume: 120, Issue:6

    Topics: Analgesics; Animals; Formaldehyde; Injections, Spinal; Ketamine; Male; Neurons; Pain; Pain Measureme

2004
Prospective audit of short-term concurrent ketamine, opioid and anti-inflammatory ('triple-agent') therapy for episodes of acute on chronic pain.
    Internal medicine journal, 2005, Volume: 35, Issue:1

    Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Analgesics; Analgesics, Opioid; Anti-Inflammatory Age

2005
Ketamine enhances the efficacy to and delays the development of tolerance to electroacupuncture-induced antinociception in rats.
    Neuroscience letters, 2005, Feb-28, Volume: 375, Issue:2

    Topics: Adaptation, Physiological; Analgesics; Animals; Brain; Dose-Response Relationship, Drug; Electroacup

2005
Preemptive effect of intravenous ketamine in the rat: concordance between pain behavior and spinal fos-like immunoreactivity.
    Acta anaesthesiologica Scandinavica, 2005, Volume: 49, Issue:2

    Topics: Analgesics; Analysis of Variance; Animals; Behavior, Animal; Disease Models, Animal; Disinfectants;

2005
Neuropathological findings after continuous intrathecal administration of S(+)-ketamine for the management of neuropathic cancer pain.
    Pain, 2005, Volume: 117, Issue:1-2

    Topics: Analgesics; Female; Humans; Ketamine; Middle Aged; Neoplasms; Pain; Postmortem Changes; Spinal Cord

2005
Combined therapy with clonidine and amantadine may act in two stages of glutamate-mediated neuropathic pain caused by a needle puncture in an upper extremity.
    Anesthesia and analgesia, 2005, Volume: 101, Issue:3

    Topics: Adrenergic alpha-Agonists; Adult; Amantadine; Analgesics, Non-Narcotic; Calcium Channel Blockers; Ca

2005
Alternative treatments of breakthrough pain in patients receiving spinal analgesics for cancer pain.
    Journal of pain and symptom management, 2005, Volume: 30, Issue:5

    Topics: Administration, Sublingual; Adult; Aged; Analgesics; Anesthetics, Local; Bupivacaine; Female; Humans

2005
Effects of ketamine on acute somatic nociception in wild-type and N-methyl-D-aspartate (NMDA) receptor epsilon1 subunit knockout mice.
    Neuropharmacology, 2006, Volume: 50, Issue:6

    Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Aci

2006
Effects of initial pain treatment on sedation recovery time in pediatric emergency care.
    Pediatric emergency care, 2006, Volume: 22, Issue:2

    Topics: Adolescent; Analgesics; Analgesics, Opioid; Anesthesia Recovery Period; Child; Child, Preschool; Con

2006
The potential role of spinal ketamine in multi-component antinociception.
    Ideggyogyaszati szemle, 2006, Jan-20, Volume: 59, Issue:1-2

    Topics: Analgesics; Animals; Drug Therapy, Combination; Injections, Spinal; Ketamine; Male; Pain; Pain Measu

2006
[Postponed or canceled drug challenge tests and side effects of the test drug--a report of four cases].
    Masui. The Japanese journal of anesthesiology, 2006, Volume: 55, Issue:2

    Topics: Adult; Aged; Arthritis, Rheumatoid; Chronic Disease; Female; Fibromyalgia; Humans; Intervertebral Di

2006
Spinal ventral root after-discharges as a pain index: involvement of NK-1 and NMDA receptors.
    Brain research, 2006, Apr-12, Volume: 1082, Issue:1

    Topics: Action Potentials; Analysis of Variance; Animals; Benzylamines; Bridged Bicyclo Compounds, Heterocyc

2006
The antiallodynic effect of NMDA antagonists in neuropathic pain outlasts the duration of the in vivo NMDA antagonism.
    Neuropharmacology, 2006, Volume: 51, Issue:1

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analgesics, Opioid; Animals; Cold Temperat

2006
Safe and efficacious use of procedural sedation and analgesia by non-anesthesiologists in a pediatric hematology-oncology unit.
    Indian pediatrics, 2006, Volume: 43, Issue:4

    Topics: Adolescent; Analgesics; Child; Child, Preschool; Drug Therapy, Combination; Female; Follow-Up Studie

2006
Enhancement of morphine antinociception with the peptide N-methyl-D-aspartate receptor antagonist [Ser1]-histogranin in the rat formalin test.
    Brain research, 2006, Jun-20, Volume: 1095, Issue:1

    Topics: Analgesics, Opioid; Analysis of Variance; Animals; Behavior, Animal; Dose-Response Relationship, Dru

2006
Depression of NMDA-receptor-mediated segmental transmission by ketamine and ketoprofen, but not L-NAME, on the in vitro neonatal rat spinal cord preparation.
    Brain research, 2006, Jun-13, Volume: 1094, Issue:1

    Topics: Afferent Pathways; Animals; Animals, Newborn; Cyclooxygenase Inhibitors; Dose-Response Relationship,

2006
Subanesthetic ketamine for cancer pain and scientific rigor in cancer pain trials. A reply to Jackson et al.
    Journal of pain and symptom management, 2006, Volume: 31, Issue:5

    Topics: Analgesics; Clinical Trials as Topic; Humans; Ketamine; Neoplasms; Pain

2006
Ketamine and HTLV-1 myelopathy: NMDA blockade and immunomodulation?
    Journal of pain and symptom management, 2006, Volume: 31, Issue:5

    Topics: Excitatory Amino Acid Antagonists; HTLV-I Infections; Human T-lymphotropic virus 1; Humans; Immunolo

2006
Procedural sedation and analgesia in children.
    Lancet (London, England), 2006, Jun-10, Volume: 367, Issue:9526

    Topics: Analgesia; Analgesics; Child; Conscious Sedation; Drug Combinations; Humans; Hypnotics and Sedatives

2006
Evidence-based pain management and palliative care in Issue One for 2006 of The Cochrane Library.
    Journal of pain & palliative care pharmacotherapy, 2006, Volume: 20, Issue:3

    Topics: Analgesics; Analgesics, Opioid; Clinical Trials as Topic; Cryotherapy; Evidence-Based Medicine; Huma

2006
Characterization of the antinociceptive and anti-inflammatory activities of riboflavin in different experimental models.
    European journal of pharmacology, 2006, Oct-10, Volume: 547, Issue:1-3

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Body Temperature; Carrageenan; Dose

2006
[Dextromethorphan enhances analgesic activity of propacetamol--experimental study].
    Folia medica Cracoviensia, 2005, Volume: 46, Issue:1-2

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Behavior, Animal; Dextromethorphan; Dose-Response

2005
Pain management in fulminating ulcerative colitis.
    Paediatric anaesthesia, 2006, Volume: 16, Issue:11

    Topics: Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Child; Colitis, Ulcerative; Contraind

2006
Consigning "brutacaine" to history: a survey of pharmacological techniques to facilitate painful procedures in children in emergency departments in the UK.
    Emergency medicine journal : EMJ, 2006, Volume: 23, Issue:11

    Topics: Administration, Intranasal; Administration, Topical; Analgesics; Anesthesia, Local; Child; Emergency

2006
[Effect of intrathecal katemine on the expression of nNOS in spinal dorsal horn in rats with formalin pain].
    Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2006, Volume: 31, Issue:5

    Topics: Analgesics; Animals; Formaldehyde; Injections, Spinal; Ketamine; Male; Nitric Oxide Synthase Type I;

2006
Deep sedation with intravenous infusion of combined propofol and ketamine during dressing changes and whirlpool bath in patients with severe epidermolysis bullosa.
    Paediatric anaesthesia, 2007, Volume: 17, Issue:6

    Topics: Adolescent; Analgesics; Anesthetics, Intravenous; Anti-Bacterial Agents; Antibiotics, Antitubercular

2007
[Italian guidelines and recommendations for prevention and treatment of pain in the newborn].
    La Pediatria medica e chirurgica : Medical and surgical pediatrics, 2006, Volume: 28, Issue:1-3

    Topics: Adjuvants, Anesthesia; Analgesics; Analgesics, Opioid; Anesthetics, Local; Atropine; Drug Therapy, C

2006
Ketamine reduces the cell death following inflammatory pain in newborn rat brain.
    Pediatric research, 2007, Volume: 62, Issue:3

    Topics: Analgesics; Animals; Animals, Newborn; Behavior, Animal; Brain; Cell Death; Female; Humans; Infant,

2007
Why not ketamine?
    Pain practice : the official journal of World Institute of Pain, 2007, Volume: 7, Issue:2

    Topics: Excitatory Amino Acid Antagonists; Humans; Ketamine; Pain

2007
Ketamine: it is not just for kids anymore.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:6

    Topics: Analgesics; Analgesics, Opioid; Anesthetics, Dissociative; Animals; Conscious Sedation; Drug Therapy

2007
Ketamine versus lidocaine for the pain of propofol injection.
    Anesthesia and analgesia, 2007, Volume: 105, Issue:2

    Topics: Humans; Injections, Intravenous; Ketamine; Lidocaine; Pain; Propofol

2007
Ketamine for reducing propofol-induced pain.
    Anesthesia and analgesia, 2007, Volume: 105, Issue:2

    Topics: Humans; Ketamine; Pain; Propofol

2007
Long-term use of an intravenous ketamine infusion in a child with significant burns.
    Paediatric anaesthesia, 2007, Volume: 17, Issue:11

    Topics: Analgesia; Analgesics; Burns; Child; Humans; Infusions, Intravenous; Ketamine; Male; Pain; Time Fact

2007
Acupuncture, ketamine and piriformis syndrome--a case report from palliative care.
    Acupuncture in medicine : journal of the British Medical Acupuncture Society, 2007, Volume: 25, Issue:3

    Topics: Acupuncture Therapy; Amines; Analgesics; Combined Modality Therapy; Cyclohexanecarboxylic Acids; Gab

2007
Ketamine for prehospital use: new look at an old drug.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:8

    Topics: Adolescent; Adult; Aged; Air Ambulances; Analgesics; Anesthetics, Dissociative; Child; Child, Presch

2007
Anaesthesia in retinopathy of prematurity treatment.
    Eye (London, England), 2008, Volume: 22, Issue:1

    Topics: Analgesics; Anesthesia; Humans; Infant, Newborn; Ketamine; Laser Therapy; Pain; Retinopathy of Prema

2008
World Institute of Pain (WIP)--Fourth World Congress.
    IDrugs : the investigational drugs journal, 2007, Volume: 10, Issue:12

    Topics: Animals; Back Pain; Clinical Trials as Topic; Humans; Ketamine; Neoplasms; Pain; Pain Management; Ra

2007
Use of ketamine for ischemic pain in end-stage renal failure.
    Journal of pain and symptom management, 2008, Volume: 35, Issue:3

    Topics: Adult; Analgesics; Humans; Ischemia; Ketamine; Kidney Failure, Chronic; Male; Pain

2008
Oral ketamine for pain relief in a child with abdominal malignancy.
    Pain medicine (Malden, Mass.), 2009, Volume: 10, Issue:1

    Topics: Abdominal Neoplasms; Administration, Oral; Analgesics; Child, Preschool; Fatal Outcome; Humans; Keta

2009
Discrimination of electric shock: effects of some opioid and nonopioid drugs.
    The Journal of pharmacology and experimental therapeutics, 1980, Volume: 213, Issue:2

    Topics: Analgesics, Opioid; Animals; Drug Interactions; Electroshock; Haplorhini; Ketamine; Male; Narcotic A

1980
[Treatment of pain and anesthesia in emergency and catastrophe medicine (author's transl)].
    MMW, Munchener medizinische Wochenschrift, 1981, Feb-06, Volume: 123, Issue:6

    Topics: Analgesics, Opioid; Anesthesia, General; Disasters; Emergencies; Humans; Ketamine; Pain; Wounds and

1981
[Principles of preclinical pain treatment of emergency patients].
    Zeitschrift fur arztliche Fortbildung, 1984, Volume: 78, Issue:14

    Topics: Analgesics; Anesthesia, Inhalation; Anesthesia, Local; Emergencies; First Aid; Humans; Ketamine; Mep

1984
[Analgesia and anesthesia with ketamine at the emergency site and in transport].
    Zeitschrift fur arztliche Fortbildung, 1984, Volume: 78, Issue:14

    Topics: Anesthesia, Intravenous; Dose-Response Relationship, Drug; Emergencies; First Aid; Humans; Ketamine;

1984
Infusion analgesia for acute war injuries. A comparison of pentazocine and ketamine.
    Anaesthesia, 1984, Volume: 39, Issue:6

    Topics: Adult; Analgesia; Blood Pressure; Cambodia; Female; Humans; Infusions, Parenteral; Ketamine; Male; M

1984
Bioavailability, pharmacokinetics, and analgesic activity of ketamine in humans.
    Journal of pharmaceutical sciences, 1982, Volume: 71, Issue:5

    Topics: Administration, Oral; Adult; Analgesics; Biological Availability; Humans; Injections, Intramuscular;

1982
Bioavailability, pharmacokinetics, and analgesic activity of ketamine in humans.
    Journal of pharmaceutical sciences, 1982, Volume: 71, Issue:5

    Topics: Administration, Oral; Adult; Analgesics; Biological Availability; Humans; Injections, Intramuscular;

1982
Bioavailability, pharmacokinetics, and analgesic activity of ketamine in humans.
    Journal of pharmaceutical sciences, 1982, Volume: 71, Issue:5

    Topics: Administration, Oral; Adult; Analgesics; Biological Availability; Humans; Injections, Intramuscular;

1982
Bioavailability, pharmacokinetics, and analgesic activity of ketamine in humans.
    Journal of pharmaceutical sciences, 1982, Volume: 71, Issue:5

    Topics: Administration, Oral; Adult; Analgesics; Biological Availability; Humans; Injections, Intramuscular;

1982
Activation of the supraspinal pain inhibition system by ketamine hydrochloride.
    Acta anaesthesiologica Scandinavica, 1981, Volume: 25, Issue:4

    Topics: Animals; Bradykinin; Cats; Decerebrate State; Female; Ketamine; Male; Pain; Pentobarbital; Spinal Co

1981
Effective treatment of severe cancer pain of the head using low-dose ketamine in an opioid-tolerant patient.
    Journal of pain and symptom management, 1995, Volume: 10, Issue:4

    Topics: Adult; Carcinoma, Squamous Cell; Dose-Response Relationship, Drug; Drug Tolerance; Humans; Ketamine;

1995
Effective treatment of severe cancer pain of the head using low-dose ketamine in an opioid-tolerant patient.
    Journal of pain and symptom management, 1995, Volume: 10, Issue:4

    Topics: Adult; Carcinoma, Squamous Cell; Dose-Response Relationship, Drug; Drug Tolerance; Humans; Ketamine;

1995
Effective treatment of severe cancer pain of the head using low-dose ketamine in an opioid-tolerant patient.
    Journal of pain and symptom management, 1995, Volume: 10, Issue:4

    Topics: Adult; Carcinoma, Squamous Cell; Dose-Response Relationship, Drug; Drug Tolerance; Humans; Ketamine;

1995
Effective treatment of severe cancer pain of the head using low-dose ketamine in an opioid-tolerant patient.
    Journal of pain and symptom management, 1995, Volume: 10, Issue:4

    Topics: Adult; Carcinoma, Squamous Cell; Dose-Response Relationship, Drug; Drug Tolerance; Humans; Ketamine;

1995
Differential effects of N-methyl-D-aspartate (NMDA) and non-NMDA receptor antagonists on the responses of rat spinal neurons with joint input.
    Neuroscience letters, 1993, May-28, Volume: 155, Issue:1

    Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-

1993
Response of chronic neuropathic pain syndromes to ketamine: a role for norketamine?
    Pain, 1995, Volume: 60, Issue:1

    Topics: Humans; Ketamine; Pain; Pain, Intractable

1995
The involvement of N-methyl-D-aspartate (NMDA) and non-NMDA receptors in the responsiveness of rat spinal neurons with input from the chronically inflamed ankle.
    Neuroscience letters, 1994, Apr-11, Volume: 170, Issue:2

    Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Afferent Pathways; Animals; Ankle

1994
[Analgetic ketamine feasible in ambulance emergency care].
    Nederlands tijdschrift voor geneeskunde, 1994, Nov-12, Volume: 138, Issue:46

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Akathisia, Drug-Induced; Child; Cognition Disorders; Eme

1994
Paradoxical pain.
    Lancet (London, England), 1993, Jan-23, Volume: 341, Issue:8839

    Topics: Adenocarcinoma; Breast Neoplasms; Female; Humans; Ketamine; Middle Aged; Morphine; Pain

1993
Intrathecal treatment with dextrorphan or ketamine potently reduces pain-related behaviors in a rat model of peripheral mononeuropathy.
    Brain research, 1993, Mar-05, Volume: 605, Issue:1

    Topics: Animals; Behavior, Animal; Dextrorphan; Injections, Spinal; Ketamine; Male; Pain; Pain Measurement;

1993
Stewart smiled.
    Pediatrics, 1993, Volume: 91, Issue:5

    Topics: Child; Conscious Sedation; Humans; Ketamine; Pain

1993
Effect of propofol on spinal dorsal horn neurons. Comparison with lack of ketamine effects.
    Anesthesiology, 1995, Volume: 83, Issue:6

    Topics: Action Potentials; Anesthetics, Intravenous; Animals; Blood Pressure; Cats; Ketamine; Neurons; Pain;

1995
[Ketamine and phantom pain].
    Ugeskrift for laeger, 1995, Nov-27, Volume: 157, Issue:48

    Topics: Anesthetics, Dissociative; Humans; Ketamine; Nociceptors; Pain; Phantom Limb

1995
A correlogram analysis of the activity in the rostral ventromedial medulla of awake rats and in rats anesthetized with ketamine or pentobarbital following the administration of morphine.
    Experimental brain research, 1995, Volume: 106, Issue:2

    Topics: Action Potentials; Analgesics, Opioid; Animals; Data Interpretation, Statistical; Drug Combinations;

1995
Systemic ketamine attenuates nociceptive behaviors in a rat model of peripheral neuropathy.
    Brain research, 1996, Apr-09, Volume: 715, Issue:1-2

    Topics: Animals; Behavior, Animal; Cold Temperature; Dose-Response Relationship, Drug; Excitatory Amino Acid

1996
[Conduction anesthesia and analgesia in emergency cases. From pain to its treatment].
    Cahiers d'anesthesiologie, 1995, Volume: 43, Issue:6

    Topics: Analgesia; Analgesics, Opioid; Anesthesia, Conduction; Anti-Inflammatory Agents, Non-Steroidal; Emer

1995
[Cancer pain: beneficial effect of ketamine addition to spinal administration of morphine-clonidine-lidocaine mixture].
    Annales francaises d'anesthesie et de reanimation, 1996, Volume: 15, Issue:3

    Topics: Aged; Analgesics; Catheters, Indwelling; Clonidine; Drug Combinations; Drug Synergism; Female; Human

1996
Acute phantom limb pain controlled by ketamine.
    Anaesthesia and intensive care, 1995, Volume: 23, Issue:5

    Topics: Acute Disease; Adolescent; Anesthetics, Dissociative; Humans; Infusions, Intravenous; Ketamine; Male

1995
Ketamine injection used orally.
    Palliative medicine, 1996, Volume: 10, Issue:3

    Topics: Administration, Oral; Adult; Drug Resistance; Excitatory Amino Acid Antagonists; Hospice Care; Human

1996
[Analgesic effect of ketamine in a patient with neuropathic pain].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1996, Oct-30, Volume: 116, Issue:26

    Topics: Administration, Oral; Anesthetics, Dissociative; Female; Fibromyalgia; Humans; Ketamine; Middle Aged

1996
Efficacy of spinal NMDA receptor antagonism in formalin hyperalgesia and nerve injury evoked allodynia in the rat.
    The Journal of pharmacology and experimental therapeutics, 1997, Volume: 280, Issue:2

    Topics: 2-Amino-5-phosphonovalerate; Analgesics; Animals; Dextromethorphan; Dextrorphan; Dizocilpine Maleate

1997
Successful use of ketamine for central pain.
    Palliative medicine, 1997, Volume: 11, Issue:1

    Topics: Adult; Humans; Ketamine; Male; Pain

1997
Long-term treatment of chronic neuropathic pain with the NMDA (N-methyl-D-aspartate) receptor antagonist ketamine.
    Acta anaesthesiologica Scandinavica, 1997, Volume: 41, Issue:3

    Topics: Central Nervous System; Chronic Disease; Excitatory Amino Acid Antagonists; Humans; Ketamine; Pain

1997
Ketamine: relief from chronic pain through actions at the NMDA receptor?
    Pain, 1996, Volume: 68, Issue:2-3

    Topics: Anesthetics, Dissociative; Chronic Disease; Excitatory Amino Acid Antagonists; Humans; Ketamine; Pai

1996
Phantom limb pain.
    Anaesthesia and intensive care, 1996, Volume: 24, Issue:2

    Topics: Adolescent; Analgesics; Anesthetics, Dissociative; Humans; Ketamine; Nociceptors; Pain; Phantom Limb

1996
Reply to S.T. Meller: Ketamine: relief from chronic pain through actions at the NMDA receptor.
    Pain, 1997, Volume: 72, Issue:1-2

    Topics: Chronic Disease; Excitatory Amino Acid Antagonists; Humans; Ketamine; Pain; Receptors, N-Methyl-D-As

1997
Subpial vacuolar myelopathy after intrathecal ketamine: report of a case.
    Pain, 1997, Volume: 73, Issue:1

    Topics: Anesthetics, Intravenous; Carcinoid Tumor; Chronic Disease; Fatal Outcome; Humans; Injections, Spina

1997
Preemptive intrathecal ketamine delays mechanical hyperalgesia in the neuropathic rat.
    Anesthesia and analgesia, 1998, Volume: 86, Issue:3

    Topics: Anesthetics, Dissociative; Animals; Female; Hyperalgesia; Injections, Spinal; Ketamine; Nerve Compre

1998
Intraplantar injection of dextrorphan, ketamine or memantine attenuates formalin-induced behaviors.
    Brain research, 1998, Feb-23, Volume: 785, Issue:1

    Topics: Animals; Dextrorphan; Foot; Formaldehyde; Injections, Intradermal; Ketamine; Male; Memantine; Motor

1998
The NMDA-receptor antagonist ketamine abolishes neuropathic pain after epidural administration in a clinical case.
    Pain, 1998, Volume: 75, Issue:2-3

    Topics: Adolescent; Causalgia; Humans; Injections, Epidural; Ketamine; Leg; Male; Pain; Receptors, N-Methyl-

1998
Substitution of another opioid for morphine. Opioid toxicity should be managed initially by decreasing the opioid dose.
    BMJ (Clinical research ed.), 1998, Jul-04, Volume: 317, Issue:7150

    Topics: Analgesics, Opioid; Anesthetics, Dissociative; Humans; Ketamine; Morphine; N-Methylaspartate; Pain;

1998
Ketamine analgesia in vasculitic pain.
    British journal of rheumatology, 1998, Volume: 37, Issue:6

    Topics: Aged; Aged, 80 and over; Analgesia; Anesthetics, Dissociative; Drug Therapy, Combination; Fatal Outc

1998
Ketamine analgesia, NMDA receptors and the gates of perception.
    Acta anaesthesiologica Scandinavica, 1998, Volume: 42, Issue:7

    Topics: Analgesics; Arteriosclerosis; Chronic Disease; Excitatory Amino Acid Antagonists; Humans; Ion Channe

1998
Substitution of another opioid for morphine. Methadone can be used to manage neuropathic pain related to cancer.
    BMJ (Clinical research ed.), 1998, Jul-04, Volume: 317, Issue:7150

    Topics: Analgesics, Opioid; Anesthetics, Dissociative; Humans; Ketamine; Methadone; N-Methylaspartate; Neopl

1998
Use of ketamine in a pain management protocol for repetitive procedures.
    Pediatrics, 1998, Volume: 102, Issue:2 Pt 1

    Topics: Anesthetics, Dissociative; Bandages; Child; Conscious Sedation; Debridement; Drug Therapy, Combinati

1998
Sedation for pediatric procedures, using ketamine and midazolam, in a primarily adult intensive care unit: a retrospective evaluation.
    Critical care medicine, 1998, Volume: 26, Issue:11

    Topics: Adolescent; Adult; Anesthetics, Combined; Anesthetics, Dissociative; Anesthetics, Intravenous; Child

1998
Ketamine hydrochloride--an adjunct for analgesia in dogs with burn wounds.
    Journal of the South African Veterinary Association, 1998, Volume: 69, Issue:3

    Topics: Analgesics; Animals; Anti-Bacterial Agents; Burns; Dogs; Drug Therapy, Combination; Female; Ketamine

1998
Oral ketamine is antinociceptive in the rat formalin test: role of the metabolite, norketamine.
    Pain, 1999, Volume: 81, Issue:1-2

    Topics: Administration, Oral; Animals; Behavior, Animal; Binding, Competitive; Central Nervous System; Forma

1999
Pre- versus postformalin effects of ketamine or large-dose alfentanil in the rat: discordance between pain behavior and spinal Fos-like immunoreactivity.
    Anesthesia and analgesia, 1999, Volume: 89, Issue:1

    Topics: Alfentanil; Analgesics, Opioid; Animals; Formaldehyde; Ketamine; Male; Naloxone; Pain; Proto-Oncogen

1999
Accident and emergency department led implementation of ketamine sedation in paediatric practice and parental response.
    Journal of accident & emergency medicine, 2000, Volume: 17, Issue:1

    Topics: Anesthetics, Dissociative; Attitude to Health; Child; Child, Preschool; Conscious Sedation; Emergenc

2000
Generalized hyperalgesia and allodynia following abrupt cessation of subcutaneous ketamine infusion.
    Palliative medicine, 1999, Volume: 13, Issue:5

    Topics: Aged; Analgesics; Breast Neoplasms; Female; Humans; Hyperalgesia; Infusions, Intravenous; Injections

1999
Use of intravenous ketamine-midazolam association for pain procedures in children with cancer. A prospective study.
    Paediatric anaesthesia, 1999, Volume: 9, Issue:1

    Topics: Adolescent; Analgesics; Biopsy; Biopsy, Needle; Blood Pressure; Catheterization, Central Venous; Chi

1999
Formalin-induced central sensitization in the rat: somatosensory evoked potential data.
    Neuroscience letters, 2000, Apr-07, Volume: 283, Issue:2

    Topics: Animals; Cerebral Cortex; Electric Stimulation; Evoked Potentials, Somatosensory; Formaldehyde; Hype

2000
Comments on 'Ketamine hydrochloride--an adjunct for analgesia in dogs with burn wounds'.
    Journal of the South African Veterinary Association, 1999, Volume: 70, Issue:1

    Topics: Analgesia; Analgesics; Animals; Burns; Dogs; Ketamine; Pain

1999
Repeated administration of low dose ketamine for the treatment of monoarthritic pain in the rat.
    Life sciences, 2000, Jun-08, Volume: 67, Issue:3

    Topics: Analgesics; Animals; Ankle Joint; Arthritis, Experimental; Body Weight; Disease Models, Animal; Dose

2000
NMDA receptor blockade: from the laboratory to clinical application.
    Anesthesia and analgesia, 2000, Volume: 91, Issue:4

    Topics: Adjuvants, Anesthesia; Analgesics; Anesthesia, Epidural; Anesthetics, Dissociative; Evoked Potential

2000
Comparison of the effects of MK-801, ketamine and memantine on responses of spinal dorsal horn neurones in a rat model of mononeuropathy.
    Pain, 2001, Volume: 91, Issue:1-2

    Topics: Animals; Dizocilpine Maleate; Electric Stimulation; Electrophysiology; Excitatory Amino Acid Antagon

2001
An unusual case of chronic neuropathic pain responds to an optimum frequency of intravenous ketamine infusions.
    Journal of pain and symptom management, 2001, Volume: 21, Issue:5

    Topics: Adult; Chronic Disease; Excitatory Amino Acid Antagonists; Female; Humans; Ketamine; Pain; Phantom L

2001
The reversal of fentanyl-induced tolerance by administration of "small-dose" ketamine.
    Anesthesia and analgesia, 2001, Volume: 93, Issue:1

    Topics: Adult; Analgesics, Opioid; Anesthetics, Dissociative; Drug Therapy, Combination; Drug Tolerance; Fem

2001
[Usefulness of epidural infusion of ketamine for relief of localized superficial pain].
    Masui. The Japanese journal of anesthesiology, 2001, Volume: 50, Issue:6

    Topics: Analgesia, Epidural; Analgesics; Female; Humans; Ketamine; Male; Middle Aged; Pain

2001
The long-term antinociceptive effect of intrathecal S(+)-ketamine in a patient with established morphine tolerance.
    Anesthesia and analgesia, 2001, Volume: 93, Issue:4

    Topics: Analgesics; Analgesics, Opioid; Anesthetics, Dissociative; Back Pain; Drug Tolerance; Female; Humans

2001
In response to treatment of central post-stroke pain with oral ketamine by Pamela G. Vick and Tim J. Lamer.
    Pain, 2002, Volume: 95, Issue:3

    Topics: Administration, Oral; Analgesics; Humans; Ketamine; Pain; Stroke

2002
Low dose ketamine as an analgesic adjuvant in difficult pain syndromes: a strategy for conversion from parenteral to oral ketamine.
    Journal of pain and symptom management, 2002, Volume: 23, Issue:2

    Topics: Administration, Oral; Adult; Aged; Chemotherapy, Adjuvant; Humans; Infusions, Parenteral; Ketamine;

2002
Subcutaneous formalin and intraplantar carrageenan increase nitric oxide release as measured by in vivo voltammetry in the spinal cord.
    European journal of pain (London, England), 2002, Volume: 6, Issue:1

    Topics: Animals; Carrageenan; Excitatory Amino Acid Antagonists; Formaldehyde; Inflammation; Inflammation Me

2002
Isobolographic analysis of the analgesic interactions between ketamine and tramadol.
    The Journal of pharmacy and pharmacology, 2002, Volume: 54, Issue:5

    Topics: Analgesics; Animals; Behavior, Animal; Central Nervous System; Dose-Response Relationship, Drug; Dru

2002
Experimental conditions for the continuous subcutaneous infusion of four central analgesics in rats.
    Pharmacology, biochemistry, and behavior, 2002, Volume: 72, Issue:4

    Topics: Acetates; Amines; Analgesics; Anesthetics, Dissociative; Animals; Anticonvulsants; Antidepressive Ag

2002
Potentiation by ketamine of fentanyl antinociception. I. An experimental study in rats showing that ketamine administered by non-spinal routes targets spinal cord antinociceptive systems.
    British journal of anaesthesia, 2002, Volume: 88, Issue:5

    Topics: Analgesics; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Synergism; Electric

2002
[Preliminary clinical observations on the use of the narcotic, Etomidate, in anesthesiology. Evaluation of the MPC dose and equivalent dose].
    Minerva anestesiologica, 1979, Volume: 45, Issue:3

    Topics: Adolescent; Adult; Anesthesia; Diazepam; Dose-Response Relationship, Drug; Etomidate; Humans; Imidaz

1979
Hypno-analgesia and acupuncture analgesia: a neurophysiological reality?
    Neuropsychobiology, 1975, Volume: 1, Issue:4

    Topics: Acupuncture Therapy; Adult; Analgesia; Analgesics; Blood Pressure; Brain; Computers; Electric Stimul

1975
Effects of ketamine on sensory perception: evidence for a role of N-methyl-D-aspartate receptors.
    The Journal of pharmacology and experimental therapeutics, 1992, Volume: 260, Issue:3

    Topics: Adult; Dizocilpine Maleate; Hearing; Humans; Ketamine; Male; Memory; Pain; Perception; Receptors, N-

1992
Ketamine. A solution to procedural pain in burned children.
    The Canadian nurse, 1992, Volume: 88, Issue:8

    Topics: Burn Units; Burns; Child; Humans; Ketamine; Pain; Pediatric Nursing

1992
[Effects of ketamine on behavioral responses to somatic and visceral stimuli in rats].
    Masui. The Japanese journal of anesthesiology, 1991, Volume: 40, Issue:11

    Topics: Animals; Injections, Intraperitoneal; Ketamine; Male; Pain; Rats; Rats, Inbred Strains; Tail; Viscer

1991
Evidence for a supraspinal mechanism in the opioid-mediated antinociceptive effect of ketamine.
    Brain research, 1991, Dec-06, Volume: 566, Issue:1-2

    Topics: Analgesics; Animals; Cerebral Ventricles; Injections, Intraperitoneal; Injections, Intraventricular;

1991
An analysis of neuronal responses in nucleus centrum medianum to electrical stimulation of the superficial peroneal nerve.
    Zhen ci yan jiu = Acupuncture research, 1991, Volume: 16, Issue:1

    Topics: Action Potentials; Animals; Cats; Electric Stimulation; Electroacupuncture; Ketamine; Morphine; Nerv

1991
Evidence of a role for NMDA receptors in pain perception.
    European journal of pharmacology, 1990, Oct-23, Volume: 187, Issue:3

    Topics: Humans; Ketamine; Pain; Phencyclidine; Radioligand Assay; Receptors, N-Methyl-D-Aspartate; Receptors

1990
Evidence for spinal N-methyl-D-aspartate receptor involvement in prolonged chemical nociception in the rat.
    Brain research, 1990, Jun-04, Volume: 518, Issue:1-2

    Topics: 2-Amino-5-phosphonovalerate; Animals; Dibenzocycloheptenes; Dipeptides; Dizocilpine Maleate; Electri

1990
Sedation for pediatric laceration repair.
    Annals of emergency medicine, 1991, Volume: 20, Issue:6

    Topics: Child; Emergency Medicine; Humans; Ketamine; Pain; Wounds, Penetrating

1991
Opiates modify induction of c-fos proto-oncogene in the spinal cord of the rat following noxious stimulation.
    Neuroscience letters, 1990, Mar-26, Volume: 111, Issue:1-2

    Topics: Animals; Immunohistochemistry; Ketamine; Male; Morphine; Naloxone; Pain; Proto-Oncogene Proteins; Pr

1990
N-methyl-D-aspartate receptors mediate responses of rat dorsal horn neurones to hindlimb ischemia.
    Brain research, 1990, Jul-02, Volume: 522, Issue:1

    Topics: Animals; Anterior Horn Cells; Hindlimb; Injections, Spinal; Ischemia; Ketamine; Male; Pain; Physical

1990
[Ketamine infusion for control of pain in patients with advanced cancer].
    Masui. The Japanese journal of anesthesiology, 1990, Volume: 39, Issue:10

    Topics: Adult; Aged; Aged, 80 and over; Female; Humans; Infusions, Intravenous; Ketamine; Male; Middle Aged;

1990
[Effect of ketamine on acupuncture analgesia].
    Zhen ci yan jiu = Acupuncture research, 1989, Volume: 14, Issue:4

    Topics: Acupuncture Analgesia; Animals; Electroacupuncture; Ketamine; Male; Pain; Rats; Sensory Thresholds

1989
Antagonism of methoxyflurane-induced anesthesia in rats by benzodiazepine inverse agonists.
    European journal of pharmacology, 1989, Nov-28, Volume: 173, Issue:1

    Topics: Anesthesia; Animals; Azides; Benzodiazepines; Carbolines; Electric Stimulation; Ketamine; Male; Meth

1989
Pain management in the pediatric emergency department.
    Pediatric emergency care, 1989, Volume: 5, Issue:4

    Topics: Child; Emergency Service, Hospital; Humans; Injections, Intramuscular; Ketamine; Laryngismus; Pain

1989
[Control of pain and anxiety in pedodontics].
    Revista de actualidad estomatologica espanola, 1989, Volume: 49, Issue:386

    Topics: Anesthesia, Dental; Anxiety; Child; Child, Preschool; Diazepam; Humans; Hydroxyzine; Ketamine; Nitro

1989
Pain control during the intensive care phase of burn care.
    Critical care clinics, 1985, Volume: 1, Issue:1

    Topics: Analgesia; Analgesics, Opioid; Burns; Humans; Ketamine; Pain; Pain Management

1985
Comparison of direct and indirect depressant actions of ketamine on dorsal horn cells in rabbits.
    Neuropharmacology, 1986, Volume: 25, Issue:4

    Topics: Analgesics; Animals; Bradykinin; Decerebrate State; Efferent Pathways; Ketamine; Male; Naloxone; Neu

1986
[Use of ketamine in emergency medical care].
    Anaesthesiologie und Reanimation, 1988, Volume: 13, Issue:5

    Topics: Adolescent; Adult; Aged; Child; Female; First Aid; Humans; Ketamine; Male; Middle Aged; Pain

1988
The effects of pentobarbital, fentanyl-droperidol, ketamine-xylazine and ketamine-diazepam on noxious stimulus perception in adult male rats.
    Laboratory animal science, 1987, Volume: 37, Issue:6

    Topics: Anesthesia; Anesthetics; Animals; Diazepam; Droperidol; Drug Combinations; Fentanyl; Ketamine; Male;

1987
[Studies on the intrathecal effect of ketamine in primate].
    Ma zui xue za zhi = Anaesthesiologica Sinica, 1987, Volume: 25, Issue:4

    Topics: Analgesics; Animals; Injections, Spinal; Ketamine; Macaca; Pain; Sensory Thresholds; Spinal Cord

1987
Pain management in the child.
    Emergency medicine clinics of North America, 1987, Volume: 5, Issue:4

    Topics: Administration, Topical; Anesthetics, Local; Child; Child, Preschool; Cocaine; Drug Combinations; Em

1987
Alterations in response to somatic pain associated with anaesthesia. XX. Ketamine.
    British journal of anaesthesia, 1971, Volume: 43, Issue:5

    Topics: Analgesia; Analgesics; Anesthesia, General; Atropine; Cyclohexanes; Female; Humans; Ketamine; Opium;

1971