ketamine and Ache
ketamine has been researched along with Ache in 598 studies
Ketamine: A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.
ketamine : A member of the class of cyclohexanones in which one of the hydrogens at position 2 is substituted by a 2-chlorophenyl group, while the other is substituted by a methylamino group.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "This work focused on functional connectivity changes under midazolam and ketamine sedation during performance of a memory task, with the periodic experience of pain." | 9.69 | Brain connectivity under light sedation with midazolam and ketamine during task performance and the periodic experience of pain: Examining concordance between different approaches for seed-based connectivity analysis. ( Aizenstein, HJ; Burlew, AC; Fiez, JA; Ibinson, JW; Smith, CT; Vogt, KM, 2023) |
| "To investigate if intravenous fentanyl or intravenous ketamine can provide adequate analgesia in preterm infants undergoing laser photocoagulation for retinopathy of prematurity (ROP)." | 9.41 | 'NOPAIN-ROP' trial: Intravenous fentanyl and intravenous ketamine for pain relief during laser photocoagulation for retinopathy of prematurity (ROP) in preterm infants: A randomised trial. ( Agarwal, R; Chandra, P; Deorari, A; Madathil, S; Sankar, MJ; Thomas, D; Thukral, A, 2021) |
| "Painful stimulation during light sedation with midazolam, but not ketamine, can be accompanied by increased coherence in brain connectivity, even though details are less likely to be recollected as explicit memories." | 9.41 | Midazolam and Ketamine Produce Distinct Neural Changes in Memory, Pain, and Fear Networks during Pain. ( Aizenstein, HJ; Citro, AT; Fiez, JA; Ibinson, JW; Karim, HT; Mahajan, A; Norton, CM; Popov, V; Reder, LM; Smith, CT; Vogt, KM, 2021) |
| "This study aimed to compare analgesic efficacy of intranasal (IN) ketamine to IN fentanyl for moderate to severe pain in children in a pediatric emergency department." | 9.41 | Analgesic Efficacy of Intranasal Ketamine Versus Intranasal Fentanyl for Moderate to Severe Pain in Children: A Prospective, Randomized, Double-Blind Study. ( Brady, J; Chitnis, SS; Drapkin, J; Fromm, C; Kriss, S; Likourezos, A; Motov, S; Pushkar, I; Quinn, K; Yasavolian, M, 2021) |
| "To determine whether intranasal ketamine is noninferior to intranasal fentanyl for pain reduction in children presenting with acute extremity injuries." | 9.30 | Effect of Intranasal Ketamine vs Fentanyl on Pain Reduction for Extremity Injuries in Children: The PRIME Randomized Clinical Trial. ( Caruso, M; Florin, TA; Frey, TM; Mittiga, MR; Zhang, N; Zhang, Y, 2019) |
| " This study aims to evaluate the efficacy and safety of subdissociative intranasal ketamine as a cheap, readily available and easily administered adjunct to standard pain therapy." | 9.24 | Subdissociative intranasal ketamine plus standard pain therapy versus standard pain therapy in the treatment of paediatric sickle cell disease vaso-occlusive crises in resource-limited settings: study protocol for a randomised controlled trial. ( Helm, E; Mfinanga, JA; Moore, CG; Nshom, E; Reynolds, SL; Runyon, MS; Sawe, HR; Young, JR, 2017) |
| " Ketamine mouthwashes have been used for pain relief, but supporting evidence is limited." | 9.24 | Treatment of severe mucositis pain with oral ketamine mouthwash. ( Craig, M; Cumpston, A; Hamadani, M; Kanate, AS; Shillingburg, A; Wen, S, 2017) |
| "The 3 study groups showed a highly significant, similar maximal pain reduction of 56 ± 26 mm for IN Ketamine, and 59 ± 22 and 48 ± 30 for IV MO and IM MO, respectively." | 9.22 | Intranasal ketamine for acute traumatic pain in the Emergency Department: a prospective, randomized clinical trial of efficacy and safety. ( Gigi, R; Halpern, P; Nadav, D; Rozenek, M; Sarig-Meth, T; Shapira, A; Shimonovich, S; West, D, 2016) |
| "This study was a long-term follow-up study of the prehospital, prospective, randomised, controlled, open-label study comparing ketamine with morphine in patients with trauma and a verbal pain score of >5 after 5 mg intravenous morphine." | 9.19 | Long-term pain prevalence and health-related quality of life outcomes for patients enrolled in a ketamine versus morphine for prehospital traumatic pain randomised controlled trial. ( Bernard, S; Cameron, P; Fitzgerald, M; Jennings, PA; Jolley, D; Masci, K; Walker, T, 2014) |
| "Ketamine can completely eliminate pain associated with propofol injection." | 9.17 | An effective dose of ketamine for eliminating pain during injection of propofol: a dose response study. ( Wang, M; Wang, Q; Wang, WS; Yu, YY, 2013) |
| "The lidocaine-ketamine combination is most effective for decreasing the pain on propofol injection." | 9.17 | A prospective, randomized, double-blind study to compare the efficacy of lidocaine + metoclopramide and lidocaine + ketamine combinations in preventing pain on propofol injection. ( Chaudhary, K; Gogia, AR; Gupta, P, 2013) |
| "To investigate the effects of ketamine hydrochloride on the analgesic effects of tramadol hydrochloride in horses with signs of pain associated with naturally occurring chronic laminitis." | 9.16 | Effect of ketamine hydrochloride on the analgesic effects of tramadol hydrochloride in horses with signs of chronic laminitis-associated pain. ( Guedes, AG; Hood, DM; Matthews, NS, 2012) |
| "To evaluate the efficacy of ketamine in preventing propofol injection pain in children." | 9.16 | Prevention of propofol-induced pain in children: pretreatment with small doses of ketamine. ( Bao, SM; Guo, Y; Meng, LX; Zhang, LH; Zhao, GY, 2012) |
| "02 mg, % 2 lidocaine 40 mg, metoclopramide 10 mg, and ketamine 100 microg/kg yields propofol induced pain 38%, 76%, 76%, and 58% respectively." | 9.16 | The effects of remifentanil, lidocaine, metoclopramide, or ketamine pretreatment on propofol injection pain. ( Aktay, M; Ozlü, O; Polat, R, 2012) |
| "Long-term S(+)-ketamine treatment is effective in causing pain relief in CRPS-1 patients with analgesia outlasting the treatment period by 50 days." | 9.15 | Population pharmacokinetic-pharmacodynamic modeling of ketamine-induced pain relief of chronic pain. ( Aarts, L; Bauer, M; Dahan, A; Niesters, M; Noppers, I; Olofsen, E; Sarton, E; Sigtermans, M, 2011) |
| "The purpose of this study was to evaluate differences in pain intensity, pain quality, physiological measures, and adverse effects when patients received morphine with saline (MS) compared with morphine and a small dose of ketamine (MK) before an open wound care procedure (WCP)." | 9.15 | Efficacy of small doses of ketamine with morphine to decrease procedural pain responses during open wound care. ( Arroyo-Novoa, CM; Figueroa-Ramos, MI; Miaskowski, C; Padilla, G; Paul, SM; Puntillo, KA; Rodríguez-Ortiz, P; Stotts, NA, 2011) |
| "To assess the analgesic efficacy of the N-methyl-D-aspartate receptor antagonist S(+)-ketamine on fibromyalgia pain, the authors performed a randomized double blind, active placebo-controlled trial." | 9.15 | Absence of long-term analgesic effect from a short-term S-ketamine infusion on fibromyalgia pain: a randomized, prospective, double blind, active placebo-controlled trial. ( Aarts, L; Bauer, M; Dahan, A; Geleijnse, N; Mooren, R; Niesters, M; Noppers, I; Sarton, E; Swartjes, M, 2011) |
| "Sixteen patients with neuropathic pain of various origins were randomized into two treatment groups: (S)-ketamine 0." | 9.14 | Effects of low-dose intranasal (S)-ketamine in patients with neuropathic pain. ( Azad, SC; Beyer, A; Huge, V; Lauchart, M; Magerl, W; Schelling, G; Thieme, D, 2010) |
| "Administration of ketamine 100 microg x kg(-1) immediately before propofol injection is a safe and effective method in preventing propofol injection pain." | 9.14 | Prevention of propofol injection pain with small-dose ketamine. ( Nikooseresht, M; Seifrabie, M; Zahedi, H, 2009) |
| "5 mg kg(-1) ketamine reduced the incidence and intensity of propofol injection pain, whereas 1." | 9.14 | Ketamine eliminates propofol pain but does not affect hemodynamics during induction with double-lumen tubes. ( Furuya, H; Inoue, S; Iwata, M; Kawaguchi, M; Kimura, T; Taniguchi, S; Tojo, T, 2010) |
| "A study involving the use of a mixture of ketamine and midazolam delivered via patient-controlled analgesia (PCA) device was trialed to assess its effectiveness in reducing pain associated with repeated burns dressings in an adult population." | 9.13 | Ketamine and midazolam delivered by patient-controlled analgesia in relieving pain associated with burns dressings. ( MacPherson, RD; Penfold, J; Woods, D, 2008) |
| "This open-label trial suggests benefit in pain reduction, associated CRPS symptoms, improved quality of life and ability to work following anesthetic ketamine in previously refractory CRPS patients." | 9.13 | Efficacy of ketamine in anesthetic dosage for the treatment of refractory complex regional pain syndrome: an open-label phase II study. ( Altemeyer, KH; Dieterich, HJ; Grothusen, J; Kiefer, RT; Koffler, S; Ploppa, A; Rohr, P; Schwartzman, RJ; Unertl, K, 2008) |
| "Ketamine, but not calcitonin, reduced phantom limb pain." | 9.13 | Chronic phantom limb pain: the effects of calcitonin, ketamine, and their combination on pain and sensory thresholds. ( Arendt-Nielsen, L; Björgo, S; Curatolo, M; Eichenberger, U; Neff, F; Petersen-Felix, S; Sveticic, G, 2008) |
| "The comparison of ketamine with fentanyl for pain control of pediatric orthopedic emergencies remains controversial." | 9.12 | Influence of ketamine versus fentanyl on pain relief for pediatric orthopedic emergencies: A meta-analysis of randomized controlled studies. ( Qiu, J; Xie, M, 2021) |
| "Ketamine significantly reduced ongoing pain and evoked pain to brush and pinprick, whereas lidocaine only reduced evoked pain to repetitive pinprick stimuli." | 9.12 | Differential effect of ketamine and lidocaine on spontaneous and mechanical evoked pain in patients with nerve injury pain. ( Bach, FW; Gottrup, H; Jensen, TS; Juhl, G, 2006) |
| "Little is known about the effects of low-dose S-(+)-ketamine on the cerebral processing of pain." | 9.12 | Imaging pain modulation by subanesthetic S-(+)-ketamine. ( Freynhagen, R; Kochs, EF; Sprenger, T; Tölle, TR; Valet, M; Wagner, KJ; Woltmann, R; Zimmer, C, 2006) |
| "Administration of ketamine 100 microg/kg immediately before propofol injection provided the optimal dose and timing to reduce propofol-induced pain on injection." | 9.12 | Small-dose ketamine reduces the pain of propofol injection. ( Cho, SJ; Ham, KD; Hwang, JH; Kim, YK; Koo, SW, 2006) |
| "The aim of the study was to compare in emergency settings 2 analgesic regimens, morphine with ketamine (K group) or morphine with placebo (P group), for severe acute pain in trauma patients." | 9.12 | Management of severe acute pain in emergency settings: ketamine reduces morphine consumption. ( Adnet, F; Catineau, J; Combes, X; Dolveck, F; Galinski, M; Lapostolle, F; Limoges, V; Pommier, V; Smaïl, N; Templier, F, 2007) |
| "Injection pain was twice as common with ketamine-propofol admixture than with lidocaine-propofol admixture." | 9.12 | A ketamine-propofol admixture does not reduce the pain on injection compared with a lidocaine-propofol admixture. ( Abdelaziz, AB; Cherif, R; Chettaoui, O; Kaabachi, O; Kokki, H; Ouezini, R, 2007) |
| "Propofol, a commonly used anesthetic, often causes pain on injection." | 9.12 | Painless injection of propofol: pretreatment with ketamine vs thiopental, meperidine, and lidocaine. ( Boker, A; Ertok, E; Saadawy, I, 2007) |
| "The aim of this study was to determine whether the follow-up of pain processing recovery in hyperalgesic fibromyalgia (FM) could be objectively evaluated with brain perfusion ethyl cysteinate dimer single photon computerized tomography (ECD-SPECT) after administration of ketamine." | 9.12 | Follow-up of pain processing recovery after ketamine in hyperalgesic fibromyalgia patients using brain perfusion ECD-SPECT. ( Cammilleri, S; Colavolpe, C; de Laforte, C; Guedj, E; Mundler, O; Niboyet, J, 2007) |
| "Ketamine but not lidocaine showed a significant analgesic effect in patients with neuropathic pain after spinal cord injury." | 9.11 | The analgesic effect of intravenous ketamine and lidocaine on pain after spinal cord injury. ( Gordh, T; Karlsten, R; Kvarnström, A; Quiding, H, 2004) |
| "This is the first experimental study in humans to find synergistic analgesic effects with coadministration of the N-methyl-D-aspartate receptor antagonist ketamine and morphine on pain involving central sensitization phenomena." | 9.11 | The synergistic effect of combined treatment with systemic ketamine and morphine on experimentally induced windup-like pain in humans. ( Schulte, H; Segerdahl, M; Sollevi, A, 2004) |
| "Small-dose of ketamine does not seem to be a useful adjunct to remifentanil-based anaesthesia during short, painful surgical procedures." | 9.11 | Ketamine does not decrease postoperative pain after remifentanil-based anaesthesia for tonsillectomy in adults. ( Lebrun, T; Polin, B; Sandefo, I; Van Elstraete, AC, 2004) |
| "Conscious sedation with rectally applied S(+)-ketamine and Midazolam allows safe and painless dressing changes after heat injuries in children." | 9.11 | Conscious sedation: Off-label use of rectal S(+)-ketamine and midazolam for wound dressing changes in paediatric heat injuries. ( Heinrich, M; Muensterer, OJ; Till, H; Wetzstein, V, 2004) |
| " Fentanyl also may reduce the pain of diazepam injection by blocking the opiate receptors in vessels walls." | 9.11 | The effect of ketamine and fentanyl in reducing the pain of diazepam injection. ( Azemati, M; Azemati, S; Khosravi, A; Khosravi, MB, 2004) |
| ") ketamine sedation administered by nonanesthetist physicians for painful procedures." | 9.11 | Intravenous ketamine sedation for painful oncology procedures. ( Barbour, K; Evans, D; Kobe, J; Montgomery, CJ; Rogers, P; Turnham, L; Vandebeek, C; Wilson, L, 2005) |
| "This prospective, double-blind, randomized, placebo-controlled study compares the effects of ephedrine and ketamine on injection pain, and hypotension from propofol." | 9.11 | Comparison of ephedrine and ketamine in prevention of injection pain and hypotension due to propofol induction. ( Altunkaya, H; Ayoğlu, H; Ciçek, E; Demirel, CB; Ozer, Y; Ozkoçak, I, 2005) |
| "We evaluated whether preadministration of low-dose ketamine could attenuate tourniquet pain and arterial pressure increase using high tourniquet pressure in ten healthy awake volunteers." | 9.11 | Preadministration of low-dose ketamine reduces tourniquet pain in healthy volunteers. ( Fukusaki, M; Kanaide, M; Matsumoto, S; Sumikawa, K; Takada, M; Terao, Y; Yamashita, K, 2005) |
| "A double-blind, randomized, placebo-controlled 3-week study evaluated the efficacy of topical 2% amitriptyline, 1% ketamine, and a combination of both in treating patients with neuropathic pain." | 9.11 | Topical 2% amitriptyline and 1% ketamine in neuropathic pain syndromes: a randomized, double-blind, placebo-controlled trial. ( Clark, AJ; Lynch, ME; Sawynok, J; Sullivan, MJ, 2005) |
| "The aim of the present study was to clarify the neurophysiological changes associated with analgesic and behavioral effects of low-dose ketamine HCl in patients suffering from chronic neuropathic pain." | 9.10 | Effects of low-dose ketamine on neuropathic pain: An electroencephalogram-electrooculogram/behavioral study. ( Kato, J; Kojima, T; Matsuura, M; Nagashima, M; Oga, K; Ogawa, S; Saeki, S, 2002) |
| "The incidence of pain of the infusion was significantly lower in patients pretreated with ketamine (8% vs 37%, P = 0." | 9.10 | Pretreatment with intravenous ketamine reduces propofol injection pain. ( Barbi, E; Gagliardo, A; Gerarduzzi, T; Marchetti, F; Neri, E; Sarti, A; Ventura, A, 2003) |
| "The purpose of this study was to evaluate the effect of pre-treatment with ketamine on the reduction of pain during injection of propofol in adult patients." | 9.10 | [Pre-treatment with ketamine reduces incidence and severity of pain on propofol injection]. ( Kumazawa, T; Masamune, T; Nonaka, A; Suzuki, S, 2002) |
| "The aim of this study was to assess the efficacy of dextromethorphan and ketamine relative to placebo on the acute nociceptive threshold and wind-up of second pain response in healthy male volunteers." | 9.10 | Assessment of the effect of dextromethorphan and ketamine on the acute nociceptive threshold and wind-up of the second pain response in healthy male volunteers. ( Fisher, G; Growcott, JW; Hughes, AM; Rhodes, J; Sellers, M, 2002) |
| "We examined the role of N-methyl-D-aspartate (NMDA) receptors in chronic (pathological) pain in humans by using the NMDA receptor antagonist ketamine as a probe." | 9.09 | Prolonged analgesic effect of ketamine, an N-methyl-D-aspartate receptor inhibitor, in patients with chronic pain. ( Oye, I; Rabben, T; Skjelbred, P, 1999) |
| "Anecdotal reports suggest that the general anaesthetic drug ketamine, taken orally in low doses, can give rise to some extra analgesia in patients with refractory neuropathic pain." | 9.09 | N of 1 randomised controlled trials of oral ketamine in patients with chronic pain. ( Gaines, SP; Haines, DR, 1999) |
| " We showed that, as in animals, this phenomenon, which might represent an elementary form of the central sensitization involved in various painful syndromes, depends on the activation of N-methyl-D-aspartate receptors, because it was selectively reduced after the administration of ketamine." | 9.09 | The effects of ketamine on the temporal summation (wind-up) of the R(III) nociceptive flexion reflex and pain in humans. ( Bouhassira, D; Brasseur, L; Chauvin, M; Dupont, X; Guirimand, F, 2000) |
| "To assess the suitability of ketamine for relief of pain caused by tracheal suction during ventilator treatment in newborn infants." | 9.09 | Ketamine for procedural pain relief in newborn infants. ( Fellman, V; Huttunen, P; Neuvonen, PJ; Saarenmaa, E, 2001) |
| "Pain intensity, muscle strength, static muscle endurance, pressure pain threshold, and pain tolerance at tender points and control points were assessed in 31 patients with fibromyalgia (FM), before and after intravenous administration of morphine (9 patients), lidocaine (11 patients), and ketamine (11 patients)." | 9.08 | Pain analysis in patients with fibromyalgia. Effects of intravenous morphine, lidocaine, and ketamine. ( Bäckman, E; Bengtsson, A; Bengtsson, M; Henriksson, KG; Sörensen, J, 1995) |
| " A few small studies in patients have suggested that intravenous boluses or rapid infusions of the N-methyl-D-aspartate (NMDA) antagonist ketamine relieve some neuropathic pains but also produce disturbances of cognition and mood." | 9.08 | Intravenous infusion of the NMDA antagonist, ketamine, in chronic posttraumatic pain with allodynia: a double-blind comparison to alfentanil and placebo. ( Bennett, GJ; Byas-Smith, MG; Gracely, RH; Max, MB, 1995) |
| "Ketamine has been administered epidurally and intrathecally for operative and post-operative pain control." | 9.08 | Intrathecal ketamine reduces morphine requirements in patients with terminal cancer pain. ( Chang, JY; Ho, ST; Wong, CS; Yang, CY, 1996) |
| "Ten patients (4 female, 6 male) aged 34-67 years suffering from peripheral neuropathic pain participated in a double-blind placebo-controlled study where ketamine or magnesium chloride were administered by a 10 min bolus infusion (ketamine: 0." | 9.08 | NMDA receptor blockade in chronic neuropathic pain: a comparison of ketamine and magnesium chloride. ( Arendt-Nielsen, L; Felsby, S; Jensen, TS; Nielsen, J, 1996) |
| "Ketamine-a clinical available NMDA receptor antagonist-was administered intravenously to a patient with established stump pain in a double-blind saline-controlled fashion." | 9.08 | Oral ketamine therapy in the treatment of postamputation stump pain. ( Hansen, PO; Jensen, TS; Nikolajsen, L, 1997) |
| "9% saline (1 ml) on propofol injection pain." | 9.08 | The effect of ketamine pretreatment on propofol injection pain in 100 women. ( Kua, SW; Onsiong, MK; Tan, CH, 1998) |
| " This study examined the analgesic effect of local ketamine infiltration, compared with placebo and systemic ketamine, in a human model of inflammatory pain." | 9.08 | Peripheral analgesic effects of ketamine in acute inflammatory pain. ( Galle, TS; Kehlet, H; Pedersen, JL, 1998) |
| "Ketamine in sub-dissociative doses has been shown to have analgesic effects in various pain conditions, including neuropathic and phantom-limb pain, where conventional treatment has often failed." | 9.08 | The analgesic effect of racemic ketamine in patients with chronic ischemic pain due to lower extremity arteriosclerosis obliterans. ( Gustafsson, LL; Hasselström, J; Heller, A; Persson, J; Svensson, JO; Wiklund, B, 1998) |
| "The analgesic efficiency of ketamine and pethidine was compared in experimental ischemic pain and postoperative pain after oral surgery." | 9.06 | Comparison of ketamine and pethidine in experimental and postoperative pain. ( Hustveit, O; Maurset, A; Skoglund, LA; Øye, I, 1989) |
| "Intravenous ketamine is commonly used for pain management in the civilian prehospital setting." | 9.05 | Use of ketamine for prehospital pain control on the battlefield: A systematic review. ( Cauet, A; de Rocquigny, G; Dubecq, C; Martinez, T; Pasquier, P; Peffer, J; Travers, S, 2020) |
| "Ketamine is regaining popularity in the field of anesthesia and beyond." | 9.05 | Ketamine: a versatile tool for anesthesia and analgesia. ( Barrett, W; Buxhoeveden, M; Dhillon, S, 2020) |
| "Low-dose ketamine infusions for pediatric patients with sickle cell disease painful crises resulted in improved pain scores and reduced opioid usage." | 9.01 | Ketamine Infusion for Pain Control in Acute Pediatric Sickle Cell Painful Crises. ( Hagedorn, JM; Monico, EC, 2019) |
| " All randomized controlled trials that using lidocaine for propofol injection pain in children were enrolled." | 8.95 | Efficacy of lidocaine on preventing incidence and severity of pain associated with propofol using in pediatric patients: A PRISMA-compliant meta-analysis of randomized controlled trials. ( Fu, YZ; Lang, BC; Yang, CS; Zhang, LL; Zhang, WS, 2017) |
| "This article reports a rare case of the use of low-dose ketamine infusion as an adjuvant to opioids to treat pain in sickle cell disease." | 8.90 | Ketamine infusion for sickle cell pain crisis refractory to opioids: a case report and review of literature. ( Baber, A; Foy, M; Uprety, D, 2014) |
| "The role of ketamine anesthesia in the prehospital, emergency department and operating theater settings is not well defined." | 8.89 | Ketamine: use in anesthesia. ( Andolfatto, G; Brandner, B; Ellerton, J; Marland, S; Paal, P; Strapazzon, G; Thomassen, O; Weatherall, A, 2013) |
| "For ketamine's fiftieth birthday, a narrative review of this unique drug in pain management is presented." | 8.89 | Ketamine in pain management. ( Persson, J, 2013) |
| " Ketamine is a commonly used anaesthetic agent, and in subanaesthetic doses is also given as an adjuvant to opioids for the treatment of cancer pain, particularly when opioids alone prove to be ineffective." | 8.88 | Ketamine as an adjuvant to opioids for cancer pain. ( Bell, RF; Eccleston, C; Kalso, EA, 2012) |
| "While most studies on intravenous ketamine show acute analgesic effects, three recent trials on long-term ketamine treatment (days to weeks) demonstrate the effectiveness of ketamine in causing long-term (months) relief of chronic pain." | 8.86 | Ketamine for the treatment of chronic non-cancer pain. ( Aarts, L; Dahan, A; Niesters, M; Noppers, I; Sarton, E; Smith, T, 2010) |
| "Ketamine is a commonly used anaesthetic agent, and in subanaesthetic doses is also given as an adjuvant to opioids for the treatment of cancer pain, particularly when opioids alone prove to be ineffective." | 8.82 | Ketamine as an adjuvant to opioids for cancer pain. ( Bell, R; Eccleston, C; Kalso, E, 2003) |
| "Ketamine is increasingly being used as an adjuvant to opioids in the treatment of refractory cancer pain." | 8.82 | Ketamine as adjuvant to opioids for cancer pain. A qualitative systematic review. ( Bell, RF; Eccleston, C; Kalso, E, 2003) |
| "Ketamine has diverse effects that may be of relevance to chronic pain including: N-methyl-D-aspartic acid, alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid, kainate, gamma-aminobutyric acid(A) receptors; inhibition of voltage gated Na(+) and K(+) channels and serotonin, dopamine re-uptake." | 8.82 | Ketamine in chronic pain management: an evidence-based review. ( Cousins, MJ; Hocking, G, 2003) |
| "Ketamine is an effective analgesic agent for treating a variety of neuropathic and cancer pain syndromes." | 8.82 | Parenteral ketamine as an analgesic adjuvant for severe pain: development and retrospective audit of a protocol for a palliative care unit. ( Fitzgibbon, EJ; Viola, R, 2005) |
| "To review the clinical literature evaluating the utilization of intravenous ketamine for the management of cancer-related pain, to summarize the data that suggest ketamine is an appropriate adjuvant method of providing analgesia and to report a case of successful pain management using ketamine in a patient with recurrent testicular cancer at our institution." | 8.81 | Adjuvant ketamine analgesia for the management of cancer pain. ( Baroletti, SA; McQueen, AL, 2002) |
| "Ketamine infusions are frequently employed for refractory complex regional pain syndrome (CRPS), but there are limited data on factors associated with treatment response." | 8.31 | Sympathetic Blocks as a Predictor for Response to Ketamine Infusion in Patients with Complex Regional Pain Syndrome: A Multicenter Study. ( Cheng, J; Cohen, SJ; Cohen, SP; Khunsriraksakul, C; Moon, JY; Parker, E; Patel, N; Samen-Akinsiku, CDK; Yoo, Y; Yuan, X, 2023) |
| "Depressive symptom severity and the affective index of pain partially mediated improvements in social function after six repeated ketamine treatments among patients with bipolar or unipolar depressive disorder." | 8.31 | Pain mediates the improvement of social functions of repeated intravenous ketamine in patients with unipolar and bipolar depression. ( Gan, Y; Hu, Z; Lan, X; Li, N; Li, W; Liu, H; Ning, Y; Wang, C; Wu, Z; Ye, Y; Zhang, F; Zhou, Y, 2023) |
| "Following recognition of opioid induced hyperalgesia, the patient was managed with opioid rotation and ketamine, which resulted in prompt alleviation of pain." | 8.12 | Role of Ketamine and Opioid Rotation in the Management of Opioid Induced Hyperalgesia in a Patient With Acute Promyelocytic Leukemia. ( Akhtari, M; Cao, H; Hino, C; Ran-Castillo, D; Silvestre, J, 2022) |
| "The objective of our study was to determine safety and pharmacology (pharmacokinetics and preliminary efficacy) of intranasal (IN) ketamine for uncontrolled cancer-related pain." | 8.12 | A dose-escalation clinical trial of intranasal ketamine for uncontrolled cancer-related pain. ( Beumer, JH; Curseen, K; Egan, K; Gillespie, TW; Harvey, RD; Lane, O; Shteamer, JW; Singh, V; Sniecinski, R; Spektor, B; Switchenko, J; Tsvetkova, M; Zarrabi, AJ, 2022) |
| "To report on an unusual case of ketamine-precipitated syndrome of inappropriate antidiuretic hormone secretion (SIADH) in an individual managed by an outpatient pain specialty team." | 8.12 | Ketamine-precipitated syndrome of inappropriate antidiuretic hormone secretion in a patient with persistent lumbar pain: a case report. ( Lau, A; van Bockxmeer, JJ; Varshney, V, 2022) |
| " Inclusion criteria were 16 years or older, two or more documented pain assessments, at least one indicating severe pain, and administration of opioids and/or low-dose ketamine." | 8.12 | Opioid sparing effect of ketamine in military prehospital pain management-A retrospective study. ( Avital, G; Benov, A; Cohen, B; Gelikas, S; Kontorovich-Chen, D; Radomislensky, I; Talmy, T, 2022) |
| " However, to the best of our knowledge, no study has reported on endotracheal intubation without the use of muscle relaxants under anesthetic management with remimazolam, nor on the combination of remimazolam and ketamine." | 8.12 | Effective anesthetic management with remimazolam and ketamine without muscle relaxants for parotidectomy in a patient with myotonic dystrophy: A case report. ( Habu, MI; Ishida, Y; Toba, Y, 2022) |
| " Additionally, dissociative sedation ketamine for severe agitation/excited delirium led to less endotracheal intubation than reported in the prehospital literature." | 7.96 | Ketamine Safety and Use in the Emergency Department for Pain and Agitation/Delirium: A Health System Experience. ( Campbell, MJ; Casserly, E; Fertel, BS; Lam, SW; Meldon, SW; Mo, H; Wells, EJ, 2020) |
| "Sprague-Dawley rats (11-13 weeks) were randomly assigned to control (saline vehicle), fentanyl, or ketamine-treated groups with or without hemorrhage (n = 8 or 9 for each group)." | 7.96 | Fentanyl impairs but ketamine preserves the microcirculatory response to hemorrhage. ( Calderon, AS; Hinojosa-Laborde, C; Klemcke, HG; Ryan, KL; Scott, LL; Xiang, L, 2020) |
| " Ketamine can quickly relieve depression, and its subcutaneous administration appears to be as effective as and probably safer than its standard intravenous administration." | 7.96 | Repeated subcutaneous esketamine administration for depressive symptoms and pain relief in a terminally ill cancer patient: A case report. ( Barbosa, MG; Delfino, RS; Jackowski, AP; Sarin, LM, 2020) |
| " Ketamine is on the WHO's list of essential medications and is used for a variety of pharmacologic applications including anesthesia and acute pain management." | 7.96 | Ketamine for pain control of snake envenomation in Guinea: A case series. ( Balde, C; Benjamin, JM; Brandehoff, N; Chippaux, JP, 2020) |
| "Ketamine is beneficial in clinical settings ranging from procedural sedation to the treatment of chronic pain." | 7.96 | Ketamine for Acute Pain Management and Sedation. ( Brown, K; Tucker, C, 2020) |
| "Therapeutic interventions for neuropathic pain, such as the N-methyl-D-aspartate (NMDA) antagonist ketamine, can vary widely in effectiveness." | 7.91 | Plasticity in the dynamic pain connectome associated with ketamine-induced neuropathic pain relief. ( Bhatia, A; Bosma, RL; Cheng, JC; Davis, KD; Hemington, KS; Kim, JA; Osborne, NR; Rogachov, A; Venkatraghavan, L, 2019) |
| "Although ketamine analgesia is effective in reducing pain and facilitating the tracheal intubation of newborns in the delivery room, no data on the neurological effects of this treatment are available." | 7.88 | Prospective follow-up of a cohort of preterm infants<33 WG receiving ketamine for tracheal intubation in the delivery room: Neurological outcome at 1 and 2 years. ( Elalouf, C; Fontaine, C; Gondry, J; Kongolo, G; Le Moing, AG; Leke, A; Tourneux, P, 2018) |
| "Our objective was to describe dosing, duration, and pre- and post-infusion analgesic administration of continuous intravenous sub-dissociative dose ketamine (SDK) infusion for managing a variety of painful conditions in the emergency department (ED)." | 7.88 | Continuous Intravenous Sub-Dissociative Dose Ketamine Infusion for Managing Pain in the Emergency Department. ( Beals, T; Drapkin, J; Fromm, C; Likourezos, A; Marshall, J; Monfort, R; Motov, S, 2018) |
| "WHAT THIS ARTICLE TELLS US THAT IS NEW: BACKGROUND:: Ketamine is an N-methyl-D-aspartate receptor antagonist that reduces temporal summation of pain and modulates antinociception." | 7.88 | Brain Dynamics and Temporal Summation of Pain Predicts Neuropathic Pain Relief from Ketamine Infusion. ( Bhatia, A; Bosma, RL; Cheng, JC; Davis, KD; Hemington, KS; Kim, JA; Osborne, NR; Rogachov, A; Venkat Raghavan, L, 2018) |
| "The study evaluated the effect of intra-articular injections of ketamine and 25% dextrose with triamcinolone acetate (TA) and hyaluronic acid (HA) on joint pathology and pain behavior in monosodium iodoacetate (MIA)-induced osteoarthritis (OA) in experimental mice." | 7.85 | Intra-articular injections of ketamine and 25% dextrose improve clinical and pathological outcomes in the monosodium iodoacetate model of osteoarthritis. ( Brahma, S; Jalgaonkar, SV; Koli, PG; Kshirsagar, S; Patil, AE; Rege, NN; Salgaonkar, S; Shetty, YC; Teltumbde, PA, 2017) |
| "We report a case series on the observed effects of low-dose ketamine infusions in 4 critically ill patients with varying complications related to prolonged critical illness." | 7.83 | Low-Dose Ketamine in Chronic Critical Illness. ( Darrah, D; Moitra, A; Moitra, VK; Patel, MK; Wunsch, H, 2016) |
| "This study compared effects of the NMDA receptor antagonists ketamine and MK-801 in assays of pain-stimulated and pain-depressed behaviour in rats." | 7.83 | Effects of the noncompetitive N-methyl-d-aspartate receptor antagonists ketamine and MK-801 on pain-stimulated and pain-depressed behaviour in rats. ( Hillhouse, TM; Negus, SS, 2016) |
| "Intravenous ketamine treatment is frequently used for the management of chronic pain, especially in those patients who do not benefit from other therapies." | 7.83 | [Safety and efficacy of ketamine for pain relief]. ( Dahan, A; Niesters, M; van Kleef, M, 2016) |
| "Immunoglobulin E, ketamine cystitis, interstitial cystitis." | 7.83 | The Role of Immunoglobulin E in the Pathogenesis of Ketamine Related Cystitis and Ulcerative Interstitial Cystitis: An Immunohistochemical Study. ( Hsu, YH; Jhang, JF; Jiang, YH; Kuo, HC, 2016) |
| "The objective of this systematic review is to examine the best available evidence on the clinical effectiveness of ketamine as an adjuvant to opioid-based therapy versus opioid-based therapy alone in decreasing perioperative pain associated with opioid tolerance in adult patients, aged 18-70 years, undergoing orthopedic surgical procedures." | 7.83 | Effectiveness of ketamine as an adjuvant to opioid-based therapy in decreasing pain associated with opioid tolerance in adults undergoing orthopedic surgery: a systematic review protocol. ( Bennett, M; Bonanno, L; Kuhn, W, 2016) |
| "A low-dose ketamine infusion protocol provided significant pain relief with mostly mild side effects and no severe adverse events." | 7.81 | Low-Dose Ketamine Infusion for Emergency Department Patients with Severe Pain. ( Ahern, TL; Frazee, BW; Herring, AA; Miller, S, 2015) |
| "Before updating the French guidelines on postoperative pain treatment in 2015, the Pain Committee of the French Society of Anaesthesiology and Intensive Care (SFAR) conducted a survey on the medical use of ketamine in France." | 7.81 | Ketamine for pain management in France, an observational survey. ( Beloeil, H; Derivaux, B; Martinez, V, 2015) |
| "We studied the role of a low-dose intravenous (IV) ketamine-midazolam combination in the management of severe painful sickle cell crisis." | 7.80 | The role of a low-dose ketamine-midazolam regimen in the management of severe painful crisis in patients with sickle cell disease. ( Faris, AS; Kausalya, R; Tawfic, QA, 2014) |
| "In this retrospective study, the medical records of 50 patients hospitalized on medical and surgical units at our facility who had continuous intravenous infusions of ketamine for pain or mild sedation were reviewed." | 7.80 | Psychiatric side effects of ketamine in hospitalized medical patients administered subanesthetic doses for pain control. ( Rasmussen, KG, 2014) |
| "Examine response patterns to low-dose intravenous (IV) ketamine continuous infusions on multiple pain outcomes, and demonstrate effectiveness, safety, and tolerability of ketamine administration on general wards." | 7.79 | Effects of low-dose IV ketamine on peripheral and central pain from major limb injuries sustained in combat. ( Buckenmaier, CC; Gallagher, RM; Goldberg, C; Hanlon, AL; Kwon, KH; Polomano, RC; Rupprecht, C, 2013) |
| "The ketamine pharmacokinetics in children with minor burns are similar to those without burns." | 7.77 | Exploring the pharmacokinetics of oral ketamine in children undergoing burns procedures. ( Anderson, BJ; Brunette, KE; Herd, DW; Schulein, S; Thomas, J; Wiesner, L, 2011) |
| "To investigate the expression of protein kinase C (PKC) in the spinal dorsal horn of rats with formalin-induced pain and the effect of intrathecal ketamine on PKC expression." | 7.77 | [Effect of intrathecal ketamine injection on protein kinase C expression in the spinal dorsal horn of rats with formalin-induced pain]. ( GUO, QL; WANG, E; YAN, JQ; YANG, Y; ZOU, WY, 2011) |
| "Compared to ketamine + no VR, both patients reported less pain during ketamine + VR for all three pain ratings." | 7.77 | Combining ketamine and virtual reality pain control during severe burn wound care: one military and one civilian patient. ( Desocio, PA; Fowler, M; Gaylord, KM; Hoffman, HG; Maani, CV; Maiers, AJ, 2011) |
| "We investigated the heat pain threshold (HPT) and temporal summation threshold (TST) before and after target-controlled infusion (TCI) of ketamine with an effect-site concentration (Ce) of 30 and 60 ng/ml." | 7.77 | The effect of target-controlled infusion of low-dose ketamine on heat pain and temporal summation threshold. ( Chae, WS; Cho, SH; Jin, HC; Kim, SH; Kim, YI; Lee, JH; Lee, JS, 2011) |
| "The aim of the study was to explore the analgesic effect of the N-methyl-d-aspartate receptor (NMDAR) antagonist ketamine in acute experimental versus chronic spontaneous pain in Complex Regional Pain Syndrome type 1 (CRPS-1) patients." | 7.76 | An observational study on the effect of S+-ketamine on chronic pain versus experimental acute pain in Complex Regional Pain Syndrome type 1 patients. ( Bauer, M; Dahan, A; Mooren, R; Noppers, I; Olofsen, E; Sarton, E; Sigtermans, M, 2010) |
| "Five children and adolescents received a low-dose ketamine infusion for the treatment of sickle cell-related pain." | 7.76 | Use of low-dose ketamine infusion for pediatric patients with sickle cell disease-related pain: a case series. ( Corsi, JM; Hagstrom, JN; Loiselle, KA; Zempsky, WT, 2010) |
| "To assess the efficacy of adding ketamine to morphine nurse- or patient-controlled analgesia (NCA/PCA) infusions in treating mucositis pain in children." | 7.76 | The addition of ketamine to a morphine nurse- or patient-controlled analgesia infusion (PCA/NCA) increases analgesic efficacy in children with mucositis pain. ( Howard, RF; James, PJ; Williams, DG, 2010) |
| "The ketamine (ket) model reflects features of schizophrenia as well as secondary symptoms such as altered pain sensitivity." | 7.75 | Haloperidol and risperidone have specific effects on altered pain sensitivity in the ketamine model of schizophrenia. ( Becker, A; Grecksch, G; Hiemke, C; Ladstaetter, E; Schmitt, U; Zernig, G, 2009) |
| "The purpose of this study was to examine possible peripheral mechanisms for the reduction of propofol injection pain by the addition of ketamine." | 7.75 | Preventing pain on injection of propofol: a comparison between peripheral ketamine pre-treatment and ketamine added to propofol. ( Do, SH; Hwang, J; Jeon, YT; Lee, SC; Lim, YJ; Park, HP, 2009) |
| "To improve opioid repsonse in patients with movement-related pain by using opioid switching adding a burst of ketamine." | 7.75 | Opioid switching and burst ketamine to improve the opioid response in patients with movement-related pain due to bone metastases. ( Arcuri, E; David, F; Ferrera, P; Mercadante, S; Villari, P, 2009) |
| "Our objective was to determine if an oral ketamine swish and expectorate was a safe and effective method to alleviate mucositis pain." | 7.75 | Ketamine mouthwash for mucositis pain. ( Atayee, RS; Lin, F; Ryan, AJ, 2009) |
| "Low-dose ketamine behaves as an analgesic in the treatment of acute and chronic pain." | 7.75 | S(+)-ketamine effect on experimental pain and cardiac output: a population pharmacokinetic-pharmacodynamic modeling study in healthy volunteers. ( Bauer, M; Dahan, A; Kest, B; Mooren, R; Olofsen, E; Sarton, E; Sigtermans, M, 2009) |
| " Since 2005 to 2007, we evaluated the safety and efficacy of ketamine to control pain induced by diagnostic procedures in pediatric oncology patients." | 7.75 | [Sedation using ketamine for pain procedures in Pediatric Oncology.]. ( Bernard, F; Ricard, C; Tichit, R; Troncin, R, 2009) |
| " infusion of propofol, or propofol plus ketamine for deep sedation and analgesia was carried out in two patients with severe epidermolysis bullosa (EB) during extensive dressing changes and deep whirlpool baths." | 7.74 | Deep sedation with intravenous infusion of combined propofol and ketamine during dressing changes and whirlpool bath in patients with severe epidermolysis bullosa. ( Wu, J, 2007) |
| "We report the use of an intravenous ketamine infusion for 37 days in a 9-year-old child with 42% body surface area burns." | 7.74 | Long-term use of an intravenous ketamine infusion in a child with significant burns. ( Karsli, C; White, MC, 2007) |
| "This prospective audit was undertaken in order to document the analgesic response and adverse effects of concurrent short-term ('burst') triple-agent analgesic (ketamine, an opioid and an anti-inflammatory agent--either steroidal or non-steroidal) administration, for episodes of acute on chronic pain." | 7.73 | Prospective audit of short-term concurrent ketamine, opioid and anti-inflammatory ('triple-agent') therapy for episodes of acute on chronic pain. ( Ashby, M; Good, P; Goodchild, C; Jackson, K; Tullio, F, 2005) |
| "Pretreatment with intravenous ketamine inhibits inflammatory pain behavior and FLI expression following a formalin injection in rats, suggesting that pretreatment of ketamine plays an important role in preemptive analgesia." | 7.73 | Preemptive effect of intravenous ketamine in the rat: concordance between pain behavior and spinal fos-like immunoreactivity. ( Lee, IH; Lee, IO, 2005) |
| "Questions have been raised about the potential neurotoxicity of the neuraxial use of ketamine although ketamine and its active enantiomer S(+)-ketamine have been used intrathecally and epidurally (caudally) for the management of perioperative pain and in a variety of chronic pain syndromes." | 7.73 | Neuropathological findings after continuous intrathecal administration of S(+)-ketamine for the management of neuropathic cancer pain. ( Kruis, MR; Troost, D; van der Vegt, MH; Vranken, JH; Wegener, JT, 2005) |
| " The present study examined the effects of combinations of dextromethorphan and ketamine, two clinically used N-methyl-D-aspartate (NMDA) receptor antagonists, with amitriptyline on formalin-evoked behaviors and paw edema." | 7.72 | Peripheral interactions between dextromethorphan, ketamine and amitriptyline on formalin-evoked behaviors and paw edema in rats. ( Reid, A; Sawynok, J, 2003) |
| " We investigated here the effects of ketamine anesthesia on somatosensory processing in the rat spinal cord, thalamus, and cerebral cortex, using the quantitative 2-deoxyglucose mapping technique." | 7.72 | Effects of ketamine anesthesia on central nociceptive processing in the rat: a 2-deoxyglucose study. ( Baraldi, P; Cavazzuti, M; Giuliani, D; Lui, F; Porro, CA; Vellani, V, 2004) |
| "To determine whether intraarticular pretreatment with N-methyl-D-aspartic (NMDA) receptor antagonist ketamine or memantine currently used in humans has prophylactic analgesia in arthritic pain, we examined the effects of their intraarticular injection before carrageenan injection into the knee joint on pain-related behavior and spinal c-Fos expression in rats." | 7.72 | Intraarticular pretreatment with ketamine and memantine could prevent arthritic pain: relevance to the decrease of spinal c-fos expression in rats. ( Back, SK; Han, HC; Hong, SK; Kim, YI; Lee, KS; Min, SS; Na, HS; Yoon, SJ; Yoon, YW; Zhang, GH, 2004) |
| "The present study examined the effects of local peripheral and systemic administration of three clinically used excitatory amino acid receptor antagonists (dextromethorphan, memantine, ketamine) on pain behaviors and edema produced by formalin (1." | 7.71 | Modulation of formalin-induced behaviors and edema by local and systemic administration of dextromethorphan, memantine and ketamine. ( Reid, A; Sawynok, J, 2002) |
| "Three patients with localized superficial pain had their pain alleviated by single epidural infusion with low dose ketamine." | 7.71 | [Usefulness of epidural infusion of ketamine for relief of localized superficial pain]. ( Ikeda, M; Kamakura, T; Machida, K; Mizuno, J; Sugimoto, S, 2001) |
| "In this study, we compared pain reduction produced by IV drugs (ketamine or alfentanil) with the ability to prevent injury-induced spinal cord changes." | 7.70 | Pre- versus postformalin effects of ketamine or large-dose alfentanil in the rat: discordance between pain behavior and spinal Fos-like immunoreactivity. ( Coderre, TJ; Gilron, I; Quirion, R, 1999) |
| "We evaluated the safety and efficacy of midazolam-ketamine association to control pain induced by diagnostic procedures in paediatric oncology patients." | 7.70 | Use of intravenous ketamine-midazolam association for pain procedures in children with cancer. A prospective study. ( Granry, JC; Le Moine, P; Monrigal, JP; Pellier, I; Rialland, X; Rod, B, 1999) |
| "The aim of the present study was to observe the effect of repeated subcutaneous (sc) injections of low doses of ketamine for the treatment of acute inflammatory pain in a complete Freund's adjuvant-induced monoarthritic pain model in rats." | 7.70 | Repeated administration of low dose ketamine for the treatment of monoarthritic pain in the rat. ( Cao, Y; Han, JS; Huang, C; Wang, Y, 2000) |
| "To assess the benefit of ketamine addition to a morphine-clonidine-lidocaine mixture administered continuously by the intrathecal route for the treatment of cancer pain." | 7.69 | [Cancer pain: beneficial effect of ketamine addition to spinal administration of morphine-clonidine-lidocaine mixture]. ( Lemos, D; Muller, A, 1996) |
| "We report the effect of a single daily dose of ketamine in a 54 year old woman with fibromyalgia and severe post-traumatic neuropathic pain." | 7.69 | [Analgesic effect of ketamine in a patient with neuropathic pain]. ( Fagerlund, TH; Oye, I; Rabben, T, 1996) |
| "The therapeutic effects of dextrorphan and ketamine, two non-competitive N-methyl-D-aspartate (NMDA) receptor antagonists, on neuropathic pain-related behaviors were examined in rats with peripheral mononeuropathy induced by loose ligation of the common sciatic nerve (chronic constrictive injury, CCI)." | 7.68 | Intrathecal treatment with dextrorphan or ketamine potently reduces pain-related behaviors in a rat model of peripheral mononeuropathy. ( Frenk, H; Hayes, RL; Lu, J; Mao, J; Mayer, DJ; Price, DD, 1993) |
| "Our experience has shown ketamine to be a safe and effective method of providing pain relief during specific procedures in burned children." | 7.68 | Ketamine. A solution to procedural pain in burned children. ( Groeneveld, A; Inkson, T, 1992) |
| "The effect of ketamine infusion to control the intractable pain which had not responded to ordinary procedures in 12 patients with advanced cancer were evaluated." | 7.68 | [Ketamine infusion for control of pain in patients with advanced cancer]. ( Kanamaru, T; Katsumata, N; Mizuno, K; Ogawa, S; Saeki, S; Suzuki, H, 1990) |
| "Continuous intravenous infusions of ketamine and pentazocine have been used to provide analgesia in 18 patients with acute war injuries." | 7.67 | Infusion analgesia for acute war injuries. A comparison of pentazocine and ketamine. ( Bion, JF, 1984) |
| " doses of the full benzodiazepine inverse agonist beta-CCE immediately following cessation of exposure of rats to an anesthetic concentration of methoxyflurane significantly antagonized the duration of methoxyflurane anesthesia as measured by recovery of the righting reflex and/or pain sensitivity." | 7.67 | Antagonism of methoxyflurane-induced anesthesia in rats by benzodiazepine inverse agonists. ( Miller, DW; Tessel, RE; Yourick, DL, 1989) |
| "Ketamine has analgesic and antidepressant effects, but few studies have evaluated individual differences in antidepressant outcomes to repeated ketamine in TRD patients with comorbid pain." | 7.01 | Plasma inflammatory cytokines and treatment-resistant depression with comorbid pain: improvement by ketamine. ( Chao, Z; Lan, X; Li, H; Ning, Y; Wang, C; Zhou, Y, 2021) |
| " Secondary outcomes included postoperative visual analog scale (VAS) scores for pain and adverse effects associated with ketamine." | 7.01 | Efficacy and safety of perioperative application of ketamine on postoperative depression: A meta-analysis of randomized controlled studies. ( Gu, HW; Guo, J; Hashimoto, K; Qiu, D; Wang, XM; Yang, JJ; Zhang, GF, 2023) |
| "IN ketamine was administered at enrolment, with a supplementary dose after 15 min, if required." | 6.78 | Sub-dissociative dose intranasal ketamine for limb injury pain in children in the emergency department: a pilot study. ( Graudins, A; Meek, R; Oakley, E; Yeaman, F, 2013) |
| "Propofol is a widely used anesthetic drug because of its minor complication and also its fast effect." | 6.77 | Comparison of effects of ephedrine, lidocaine and ketamine with placebo on injection pain, hypotension and bradycardia due to propofol injection: a randomized placebo controlled clinical trial. ( Ayatollahi, V; Behdad, S; Kargar, S; Yavari, T, 2012) |
| "Cold allodynia and hyperalgesia are frequent clinical findings in patients with neuropathic pain." | 6.71 | Cold allodynia and hyperalgesia in neuropathic pain: the effect of N-methyl-D-aspartate (NMDA) receptor antagonist ketamine--a double-blind, cross-over comparison with alfentanil and placebo. ( Jørum, E; Stubhaug, A; Warncke, T, 2003) |
| " Intranasal ketamine was well tolerated with no serious adverse events." | 6.71 | Safety and efficacy of intranasal ketamine for the treatment of breakthrough pain in patients with chronic pain: a randomized, double-blind, placebo-controlled, crossover study. ( Albin, R; Brennen, L; Brookoff, D; Carr, DB; Denman, WT; Firestone, L; Goudas, LC; Green, G; Hamilton, D; Lavin, PT; Mermelstein, F; Rogers, MC; Staats, PS, 2004) |
| "The reduction in allodynia evoked by light stroking was statistically significant only for alfentanil." | 6.68 | Effects of intravenous ketamine, alfentanil, or placebo on pain, pinprick hyperalgesia, and allodynia produced by intradermal capsaicin in human subjects. ( Bennett, GJ; Gracely, RH; Max, MB; Park, KM; Robinovitz, E, 1995) |
| "Ischemic pain was induced by the submaximum effort tourniquet technique." | 6.67 | The influence of adenosine, ketamine, and morphine on experimentally induced ischemic pain in healthy volunteers. ( Ekblom, A; Segerdahl, M; Sollevi, A, 1994) |
| "Ketamine is an NMDA-blocking agent widely used in human medicine." | 6.67 | Response of chronic neuropathic pain syndromes to ketamine: a preliminary study. ( Arndt, G; Backonja, M; Check, B; Gombar, KA; Zimmermann, M, 1994) |
| "Ketamine has unique pharmacologic properties that may prevent the development of pain as well as reduce chronic pain." | 6.58 | Emerging Trends in Pain Medication Management: Back to the Future: A Focus on Ketamine. ( Atkinson, TJ; Bryant, C; Crumb, MW, 2018) |
| " A literature review was performed to ascertain potential side effects and/or adverse events when using ketamine for analgesia purposes." | 6.55 | Ketamine for Pain Management-Side Effects & Potential Adverse Events. ( Allen, CA; Ivester, JR, 2017) |
| "Ketamine is a fast acting N-methyl-d-aspartate (NMDA) receptor antagonist that provides safe and effective analgesia." | 6.55 | Low dose ketamine use in the emergency department, a new direction in pain management. ( Alhawas, R; Mazer-Amirshahi, M; Pourmand, A; Royall, C; Shesser, R, 2017) |
| "Ketamine is a phencyclidine derivative, which functions primarily as an antagonist of the N-methyl-D-aspartate receptor." | 6.53 | Ketamine: A Review of Clinical Pharmacokinetics and Pharmacodynamics in Anesthesia and Pain Therapy. ( Hagelberg, NM; Olkkola, KT; Peltoniemi, MA; Saari, TI, 2016) |
| "Studies on oral ketamine for cancer and neuropathic pain have shown mixed results which could be partially due to significant differences in hepatic metabolism." | 6.48 | Oral ketamine in the palliative care setting: a review of the literature and case report of a patient with neurofibromatosis type 1 and glomus tumor-associated complex regional pain syndrome. ( Baker, K; Berger, AM; Handel, D; Mannes, AJ; Ruppert, SL; Soto, E; Stewart, DR; Zlott, D, 2012) |
| "Ketamine is a lipophilic, general anesthetic." | 6.48 | Ketamine for pain: an update of uses in palliative care. ( Prommer, EE, 2012) |
| "Ketamine has become increasingly recognized as a drug of recreational use." | 6.47 | Recreational ketamine: from pleasure to pain. ( Baker, SC; Cottrell, A; Fulford, S; Gillatt, D; Harris, M; Southgate, J; Wood, D; Woodhouse, C, 2011) |
| "Ketamine is an N-methyl-D-aspartate receptor antagonist that has been in clinical use in the USA for over 30 years." | 6.47 | Ketamine in pain management. ( Cohen, SP; Gupta, A; Liao, W; Plunkett, A, 2011) |
| " There was no consistent dose-response relation." | 6.46 | Use of oral ketamine in chronic pain management: a review. ( Blonk, MI; Huygen, FJ; Koder, BG; van den Bemt, PM, 2010) |
| "Ketamine has been shown to produce antihyperalgesic effects produced by incision and tissue or nerve damage, and has become popular in equine practice as an anesthetic and more recently as an analgesic for standing surgical procedures and the treatment of laminitis." | 6.46 | NMDA receptor antagonists and pain: ketamine. ( Muir, WW, 2010) |
| "Ketamine is a dissociative anaesthetic that has been used in the clinic for many years." | 6.44 | Low dose ketamine: a therapeutic and research tool to explore N-methyl-D-aspartate (NMDA) receptor-mediated plasticity in pain pathways. ( Chizh, BA, 2007) |
| " Nursing considerations include close monitoring of vital signs during the initial dosage and follow-up observations of the effectiveness of the medications." | 6.44 | The use of ketamine as adjuvant therapy to control severe pain. ( Campbell-Fleming, JM; Williams, A, 2008) |
| "Ketamine is a dissociative anaesthetic; its mechanism of action is primarily an antagonism of the N-methyl-D-aspartate (NMDA) receptor." | 6.43 | The role of ketamine in pain management. ( Schug, SA; Visser, E, 2006) |
| "Ketamine has been shown to have potent analgesic properties at low dosages." | 6.39 | Ketamine in cancer pain: an update. ( Mercadante, S, 1996) |
| " This study aimed to evaluate differences in pain management and adverse effects of ketamine and opioid administration." | 5.91 | Treating Prehospital Pain in Children: A Retrospective Chart Review Comparing the Safety and Efficacy of Prehospital Pediatric Ketamine and Opioid Analgesia. ( Brent, C; Cranford, JA; Hunt, N; Mahmood, A; Masiewicz, S; Noel, S; Wagner, D, 2023) |
| "Ketamine was started a median of 13." | 5.91 | Ketamine use for management of vaso-occlusive pain in pediatric sickle cell disease. ( Archer, NM; Donado, C; Greco, C; Harris, EM; Heeney, MM; Solodiuk, J; Vilk, E; Williams, A, 2023) |
| "Ketamine has been used in the emergency department (ED) as an anesthetic agent for procedural sedation, and when administrated in a sub-dissociative dose (low dose) at 0." | 5.72 | Paraphimosis Pain Treatment with Nebulized Ketamine in the Emergency Department. ( Barberan Parraga, C; Cen, E; Davis, A; Dove, D; Drapkin, J; Fassassi, C; Hossain, R; Mahl, E; Motov, S; Peng, Y, 2022) |
| "Erythromelalgia is a rare neurovascular pain condition characterized by erythematous, warm, and painful extremities." | 5.72 | Intravenous Ketamine Infusion as an Adjunctive Pain Treatment for Erythromelalgia: A Pediatric Case Report. ( Adams, AC; Montoya, L; Popenhagen, MP; Price, HN; Russi, DC; Singhal, NR, 2022) |
| "Ketamine infusions have been reported to help alleviate acute exacerbations or "flare-ups" of CRPS symptoms." | 5.56 | Anesthetic Management of a Complex Regional Pain Syndrome (CRPS) Patient With Ketamine. ( Mundluru, T; Saraghi, M, 2020) |
| " Complications including apnea, hypotension, hypoxia, nausea, and vomiting, along with gastroenterologist satisfaction and patients' pain score (based on Wong-Baker faces pain assessment scale), were recorded by a checklist." | 5.51 | Comparing the Efficacy and Safety of Dexmedetomidine/Ketamine with Propofol/Fentanyl for Sedation in Colonoscopy Patients: A Doubleblinded Randomized Clinical Trial. ( Aghaali, M; Ahmadpour, S; Alemi, F; Aminnejad, R; Hormati, A; Hormati, M; Sabouri, SM; Saeidi, M; Shafiee, H, 2022) |
| "Patients with advanced cancer often suffer from both severe pain and severe symptoms of depression." | 5.48 | Case Report: Ketamine for Pain and Depression in Advanced Cancer. ( Atayee, RS; Bruner, HC; Sexton, J, 2018) |
| " This adverse effect has not been reported previously at this dosing range." | 5.46 | A Case Report: Subanesthetic Ketamine Infusion for Treatment of Cancer-Related Pain Produces Urinary Urge Incontinence. ( Hunsberger, J; Lee, W; Vickers, BA, 2017) |
| "To investigate if intravenous fentanyl or intravenous ketamine can provide adequate analgesia in preterm infants undergoing laser photocoagulation for retinopathy of prematurity (ROP)." | 5.41 | 'NOPAIN-ROP' trial: Intravenous fentanyl and intravenous ketamine for pain relief during laser photocoagulation for retinopathy of prematurity (ROP) in preterm infants: A randomised trial. ( Agarwal, R; Chandra, P; Deorari, A; Madathil, S; Sankar, MJ; Thomas, D; Thukral, A, 2021) |
| " Optimal nonsurgical management strategies for these patients have not been fully defined regarding level of care, incentive spirometry (IS), noninvasive positive pressure ventilation (NIPPV), and the use of ketamine, epidural, and other locoregional approaches to analgesia." | 5.41 | Non-surgical management and analgesia strategies for older adults with multiple rib fractures: A systematic review, meta-analysis, and joint practice management guideline from the Eastern Association for the Surgery of Trauma and the Chest Wall Injury Soc ( Agarwal, SK; Barraco, R; Bauman, ZM; Brooks, SE; Cantrell, S; Como, JJ; Crandall, M; Haines, KL; Haut, ER; Kaafarani, H; Kasotakis, G; Kaups, KL; Kim, B; Knowlton, LM; Mukherjee, K; Nirula, R; Schubl, SD; Shiroff, AM; Staudenmayer, K; Tominaga, G, 2023) |
| "We identified similar high rates of pain reduction and rare adverse events among pediatric patients who received ketamine or opioids." | 5.41 | A Comparison of Prehospital Pediatric Analgesic Use of Ketamine and Opioids. ( Chen, NW; Crowe, R; Frawley, J; Gappy, R; Goyal, A; Sandoval, S; Swor, R, 2023) |
| " NMDA receptor antagonists versus no treatment, placebo, oral sweet solution, or non-pharmacological intervention One RCT evaluated using oral ketamine (10 mg/kg body weight) versus sugar syrup (66." | 5.41 | Non-opioid analgesics for procedural pain in neonates. ( Bruschettini, M; Persad, E; Pizarro, AB, 2023) |
| "In non-intubated general anesthesia, the combination of subclinical doses of esketamine and propofol did reduce circulatory and respiratory depression, injection pain, and other adverse effects, while the incidence of esketamine's own side effects such as neuropsychiatric reactions did not increase, and the combination of the two did not cause the occurrence of new and more serious adverse reactions, and the combination of the two was safe and effective." | 5.41 | Analysis of the efficacy of subclinical doses of esketamine in combination with propofol in non-intubated general anesthesia procedures - a systematic review and meta-analysis. ( Chen, H; Ding, X; Fu, Q; Li, P; Liu, Q; Xiang, G; Xu, L, 2023) |
| " Our review shows that: - There may be little or no difference in pain relief (single dose IN vs IV fentanyl MD 4 mm, 95% CI -8 to 16 at 30 min by 100 mm VAS; multiple doses IN vs IV fentanyl MD 0, 95%CI -0." | 5.41 | Intranasal analgesia for acute moderate to severe pain in children - a systematic review and meta-analysis. ( Austad, B; Iakovleva, E; Munblit, D; Pedersen, SA; Prescott, MG; Simpson, MR; Vallersnes, OM, 2023) |
| "Painful stimulation during light sedation with midazolam, but not ketamine, can be accompanied by increased coherence in brain connectivity, even though details are less likely to be recollected as explicit memories." | 5.41 | Midazolam and Ketamine Produce Distinct Neural Changes in Memory, Pain, and Fear Networks during Pain. ( Aizenstein, HJ; Citro, AT; Fiez, JA; Ibinson, JW; Karim, HT; Mahajan, A; Norton, CM; Popov, V; Reder, LM; Smith, CT; Vogt, KM, 2021) |
| "This study aimed to compare analgesic efficacy of intranasal (IN) ketamine to IN fentanyl for moderate to severe pain in children in a pediatric emergency department." | 5.41 | Analgesic Efficacy of Intranasal Ketamine Versus Intranasal Fentanyl for Moderate to Severe Pain in Children: A Prospective, Randomized, Double-Blind Study. ( Brady, J; Chitnis, SS; Drapkin, J; Fromm, C; Kriss, S; Likourezos, A; Motov, S; Pushkar, I; Quinn, K; Yasavolian, M, 2021) |
| "IN ketamine dose was 0." | 5.40 | Sub-dissociative-dose intranasal ketamine for moderate to severe pain in adult emergency department patients. ( Egerton-Warburton, D; Graudins, A; Meek, R; Rosengarten, P; Yeaman, F, 2014) |
| "The ketamine usage pattern was recorded: initiation, administration route, dose in the last month and frequency of usage." | 5.38 | [Cystitis and ketamine associated bladder dysfunction]. ( Arango, O; Bielsa, O; Castillo, C; García-Larrosa, A; Lorente, JA; Ventura, M, 2012) |
| "Pain was also improved, although for a shorter duration." | 5.38 | Mood and pain responses to repeat dose intramuscular ketamine in a depressed patient with advanced cancer. ( Glue, P; Perez, D; Zanicotti, CG, 2012) |
| "heat allodynia) followed by a persistent area of secondary tactile allodynia." | 5.36 | Human experimental pain models 3: heat/capsaicin sensitization and intradermal capsaicin models. ( Modir, JG; Wallace, MS, 2010) |
| "It had less effect on tactile allodynia (CCI)." | 5.35 | Effects of norketamine enantiomers in rodent models of persistent pain. ( Crooks, PA; Hojomat, M; Holtman, JR; Johnson-Hardy, JK; Kleven, M; Wala, EP, 2008) |
| "Oral ketamine has been found to be effective during invasive procedures in children with malignancy." | 5.35 | Oral ketamine for pain relief in a child with abdominal malignancy. ( Boyaci, A; Gulcu, N; Ugur, F, 2009) |
| "Premature infants experience untreated repetitive pain that may alter their brain development." | 5.34 | Ketamine reduces the cell death following inflammatory pain in newborn rat brain. ( Anand, KJ; Bhutta, AT; Garg, S; Hall, RW; Narsinghani, U; Rovnaghi, CR, 2007) |
| "Muscle pain is a major clinical problem but the underlying mechanisms and its pharmacological modulation need further investigation." | 5.32 | Pharmacological modulation of experimental phasic and tonic muscle pain by morphine, alfentanil and ketamine in healthy volunteers. ( Arendt-Nielsen, L; Graven-Nielsen, T; Jansson, Y; Schulte, H; Segerdahl, M; Sollevi, A, 2003) |
| "Dextromethorphan produced lower ED(50) values for morphine, fentanyl and sufentanil but exerted no effect on the potency of SNC80 or U50,488H." | 5.31 | Dextromethorphan and ketamine potentiate the antinociceptive effects of mu- but not delta- or kappa-opioid agonists in a mouse model of acute pain. ( Baker, AK; Hoffmann, VL; Meert, TF, 2002) |
| "Neuropathic pain has been shown to respond to drugs that block the N-methyl-D-aspartate (NMDA) receptor, such as ketamine and amantidine." | 5.31 | An unusual case of chronic neuropathic pain responds to an optimum frequency of intravenous ketamine infusions. ( Mitchell, AC, 2001) |
| "Ketamine is a non-competitive N-methyl D-aspartate (NMDA) receptor antagonist with analgesic and dissociative anesthetic properties." | 5.31 | Low dose ketamine as an analgesic adjuvant in difficult pain syndromes: a strategy for conversion from parenteral to oral ketamine. ( Fitzgibbon, EJ; Hall, P; Schroder, C; Seely, J; Viola, R, 2002) |
| "To determine whether intranasal ketamine is noninferior to intranasal fentanyl for pain reduction in children presenting with acute extremity injuries." | 5.30 | Effect of Intranasal Ketamine vs Fentanyl on Pain Reduction for Extremity Injuries in Children: The PRIME Randomized Clinical Trial. ( Caruso, M; Florin, TA; Frey, TM; Mittiga, MR; Zhang, N; Zhang, Y, 2019) |
| "His pain was diagnosed as neuropathic pain (complex regional pain syndrome, type II)." | 5.30 | The NMDA-receptor antagonist ketamine abolishes neuropathic pain after epidural administration in a clinical case. ( Miyazaki, M; Morita, S; Nanbu, T; Takahashi, H; Yanagida, H, 1998) |
| " This study aims to evaluate the efficacy and safety of subdissociative intranasal ketamine as a cheap, readily available and easily administered adjunct to standard pain therapy." | 5.24 | Subdissociative intranasal ketamine plus standard pain therapy versus standard pain therapy in the treatment of paediatric sickle cell disease vaso-occlusive crises in resource-limited settings: study protocol for a randomised controlled trial. ( Helm, E; Mfinanga, JA; Moore, CG; Nshom, E; Reynolds, SL; Runyon, MS; Sawe, HR; Young, JR, 2017) |
| " Ketamine mouthwashes have been used for pain relief, but supporting evidence is limited." | 5.24 | Treatment of severe mucositis pain with oral ketamine mouthwash. ( Craig, M; Cumpston, A; Hamadani, M; Kanate, AS; Shillingburg, A; Wen, S, 2017) |
| "Ketamine-associated uropathy frequently involves frequency, urgency, and suprapubic pain; upper urinary tract involvement is less common." | 5.22 | Systematic review and meta-analysis of ketamine-associated uropathy. ( Chan, EOT; Chan, VWS; Cheung, V; Ng, CF; Tang, TST; Teoh, JYC; Wong, MCS; Yee, CH, 2022) |
| "The 3 study groups showed a highly significant, similar maximal pain reduction of 56 ± 26 mm for IN Ketamine, and 59 ± 22 and 48 ± 30 for IV MO and IM MO, respectively." | 5.22 | Intranasal ketamine for acute traumatic pain in the Emergency Department: a prospective, randomized clinical trial of efficacy and safety. ( Gigi, R; Halpern, P; Nadav, D; Rozenek, M; Sarig-Meth, T; Shapira, A; Shimonovich, S; West, D, 2016) |
| "To determine the differences by comparing fentanyl and ketamine used in cancer-diagnosed children undergoing painful procedures." | 5.20 | The clinical effect of fentanyl in comparison with ketamine in analgesic effect for oncology procedures in children: a randomized, double-blinded, crossover trial. ( Monsereenusorn, C; Rujkijyanont, P; Traivaree, C, 2015) |
| "No difference was found in pain assessment during local anaesthetic injection between the group treated with midazolam and ketamine, and the group treated with midazolam alone." | 5.19 | A double-blind, randomised, placebo-controlled trial of oral midazolam plus oral ketamine for sedation of children during laceration repair. ( Assa, A; Barkan, S; Berkovitch, S; Breitbart, R; Brenner-Zada, G; Feldon, M; Kozer, E; Shavit, I; Toledano, M, 2014) |
| "This study was a long-term follow-up study of the prehospital, prospective, randomised, controlled, open-label study comparing ketamine with morphine in patients with trauma and a verbal pain score of >5 after 5 mg intravenous morphine." | 5.19 | Long-term pain prevalence and health-related quality of life outcomes for patients enrolled in a ketamine versus morphine for prehospital traumatic pain randomised controlled trial. ( Bernard, S; Cameron, P; Fitzgerald, M; Jennings, PA; Jolley, D; Masci, K; Walker, T, 2014) |
| " Before fracture reduction, children 3 to 17 years of age randomly received 2% lidocaine (L) or normal saline (NS) into the hematoma of their fracture site during sedation with intravenous ketamine and midazolam." | 5.19 | Evaluating the hematoma block as an adjunct to procedural sedation for closed reduction of distal forearm fractures. ( Constantine, E; Eberson, CP; Linakis, JG; Machan, JT; Steele, DW; Tsze, DS, 2014) |
| "Ketamine can completely eliminate pain associated with propofol injection." | 5.17 | An effective dose of ketamine for eliminating pain during injection of propofol: a dose response study. ( Wang, M; Wang, Q; Wang, WS; Yu, YY, 2013) |
| "The lidocaine-ketamine combination is most effective for decreasing the pain on propofol injection." | 5.17 | A prospective, randomized, double-blind study to compare the efficacy of lidocaine + metoclopramide and lidocaine + ketamine combinations in preventing pain on propofol injection. ( Chaudhary, K; Gogia, AR; Gupta, P, 2013) |
| "To investigate the effects of ketamine hydrochloride on the analgesic effects of tramadol hydrochloride in horses with signs of pain associated with naturally occurring chronic laminitis." | 5.16 | Effect of ketamine hydrochloride on the analgesic effects of tramadol hydrochloride in horses with signs of chronic laminitis-associated pain. ( Guedes, AG; Hood, DM; Matthews, NS, 2012) |
| "To evaluate the efficacy of ketamine in preventing propofol injection pain in children." | 5.16 | Prevention of propofol-induced pain in children: pretreatment with small doses of ketamine. ( Bao, SM; Guo, Y; Meng, LX; Zhang, LH; Zhao, GY, 2012) |
| " Nitrous oxide (N(2)O) has the advantages of being a sedative agent that does not require a painful injection and that offers shallower levels of sedation and a rapid recovery of mental state." | 5.16 | A randomized comparison of nitrous oxide versus intravenous ketamine for laceration repair in children. ( Eun, SC; Heo, CY; Jo, YH; Kim, K; Kim, SH; Kim, TY; Lee, JH; Rhee, JE, 2012) |
| "02 mg, % 2 lidocaine 40 mg, metoclopramide 10 mg, and ketamine 100 microg/kg yields propofol induced pain 38%, 76%, 76%, and 58% respectively." | 5.16 | The effects of remifentanil, lidocaine, metoclopramide, or ketamine pretreatment on propofol injection pain. ( Aktay, M; Ozlü, O; Polat, R, 2012) |
| "Long-term S(+)-ketamine treatment is effective in causing pain relief in CRPS-1 patients with analgesia outlasting the treatment period by 50 days." | 5.15 | Population pharmacokinetic-pharmacodynamic modeling of ketamine-induced pain relief of chronic pain. ( Aarts, L; Bauer, M; Dahan, A; Niesters, M; Noppers, I; Olofsen, E; Sarton, E; Sigtermans, M, 2011) |
| "The purpose of this study was to evaluate differences in pain intensity, pain quality, physiological measures, and adverse effects when patients received morphine with saline (MS) compared with morphine and a small dose of ketamine (MK) before an open wound care procedure (WCP)." | 5.15 | Efficacy of small doses of ketamine with morphine to decrease procedural pain responses during open wound care. ( Arroyo-Novoa, CM; Figueroa-Ramos, MI; Miaskowski, C; Padilla, G; Paul, SM; Puntillo, KA; Rodríguez-Ortiz, P; Stotts, NA, 2011) |
| "To assess the analgesic efficacy of the N-methyl-D-aspartate receptor antagonist S(+)-ketamine on fibromyalgia pain, the authors performed a randomized double blind, active placebo-controlled trial." | 5.15 | Absence of long-term analgesic effect from a short-term S-ketamine infusion on fibromyalgia pain: a randomized, prospective, double blind, active placebo-controlled trial. ( Aarts, L; Bauer, M; Dahan, A; Geleijnse, N; Mooren, R; Niesters, M; Noppers, I; Sarton, E; Swartjes, M, 2011) |
| "Sixteen patients with neuropathic pain of various origins were randomized into two treatment groups: (S)-ketamine 0." | 5.14 | Effects of low-dose intranasal (S)-ketamine in patients with neuropathic pain. ( Azad, SC; Beyer, A; Huge, V; Lauchart, M; Magerl, W; Schelling, G; Thieme, D, 2010) |
| "Administration of ketamine 100 microg x kg(-1) immediately before propofol injection is a safe and effective method in preventing propofol injection pain." | 5.14 | Prevention of propofol injection pain with small-dose ketamine. ( Nikooseresht, M; Seifrabie, M; Zahedi, H, 2009) |
| "5 mg kg(-1) ketamine reduced the incidence and intensity of propofol injection pain, whereas 1." | 5.14 | Ketamine eliminates propofol pain but does not affect hemodynamics during induction with double-lumen tubes. ( Furuya, H; Inoue, S; Iwata, M; Kawaguchi, M; Kimura, T; Taniguchi, S; Tojo, T, 2010) |
| " The aim of this study was to compare the level of pain during NG tube insertion in groups receiving local ketamine plus water-soluble lubricating gel and water-soluble lubricating gel alone (the latter is the common practice in our hospital)." | 5.14 | Ketamine improves nasogastric tube insertion. ( Golshani, K; Khashayar, P; Moharari, RS; Moradi Lakeh, M; Nejati, A, 2010) |
| "A study involving the use of a mixture of ketamine and midazolam delivered via patient-controlled analgesia (PCA) device was trialed to assess its effectiveness in reducing pain associated with repeated burns dressings in an adult population." | 5.13 | Ketamine and midazolam delivered by patient-controlled analgesia in relieving pain associated with burns dressings. ( MacPherson, RD; Penfold, J; Woods, D, 2008) |
| "This open-label trial suggests benefit in pain reduction, associated CRPS symptoms, improved quality of life and ability to work following anesthetic ketamine in previously refractory CRPS patients." | 5.13 | Efficacy of ketamine in anesthetic dosage for the treatment of refractory complex regional pain syndrome: an open-label phase II study. ( Altemeyer, KH; Dieterich, HJ; Grothusen, J; Kiefer, RT; Koffler, S; Ploppa, A; Rohr, P; Schwartzman, RJ; Unertl, K, 2008) |
| "Ketamine, but not calcitonin, reduced phantom limb pain." | 5.13 | Chronic phantom limb pain: the effects of calcitonin, ketamine, and their combination on pain and sensory thresholds. ( Arendt-Nielsen, L; Björgo, S; Curatolo, M; Eichenberger, U; Neff, F; Petersen-Felix, S; Sveticic, G, 2008) |
| "The comparison of ketamine with fentanyl for pain control of pediatric orthopedic emergencies remains controversial." | 5.12 | Influence of ketamine versus fentanyl on pain relief for pediatric orthopedic emergencies: A meta-analysis of randomized controlled studies. ( Qiu, J; Xie, M, 2021) |
| "To compare atropine with placebo as an adjunct to ketamine sedation in children undergoing minor painful procedures." | 5.12 | Is atropine needed with ketamine sedation? A prospective, randomised, double blind study. ( Geelhoed, GC; Heinz, P; Pascoe, EM; Wee, C, 2006) |
| "Ketamine significantly reduced ongoing pain and evoked pain to brush and pinprick, whereas lidocaine only reduced evoked pain to repetitive pinprick stimuli." | 5.12 | Differential effect of ketamine and lidocaine on spontaneous and mechanical evoked pain in patients with nerve injury pain. ( Bach, FW; Gottrup, H; Jensen, TS; Juhl, G, 2006) |
| "Little is known about the effects of low-dose S-(+)-ketamine on the cerebral processing of pain." | 5.12 | Imaging pain modulation by subanesthetic S-(+)-ketamine. ( Freynhagen, R; Kochs, EF; Sprenger, T; Tölle, TR; Valet, M; Wagner, KJ; Woltmann, R; Zimmer, C, 2006) |
| "Administration of ketamine 100 microg/kg immediately before propofol injection provided the optimal dose and timing to reduce propofol-induced pain on injection." | 5.12 | Small-dose ketamine reduces the pain of propofol injection. ( Cho, SJ; Ham, KD; Hwang, JH; Kim, YK; Koo, SW, 2006) |
| "The aim of the study was to compare in emergency settings 2 analgesic regimens, morphine with ketamine (K group) or morphine with placebo (P group), for severe acute pain in trauma patients." | 5.12 | Management of severe acute pain in emergency settings: ketamine reduces morphine consumption. ( Adnet, F; Catineau, J; Combes, X; Dolveck, F; Galinski, M; Lapostolle, F; Limoges, V; Pommier, V; Smaïl, N; Templier, F, 2007) |
| "Injection pain was twice as common with ketamine-propofol admixture than with lidocaine-propofol admixture." | 5.12 | A ketamine-propofol admixture does not reduce the pain on injection compared with a lidocaine-propofol admixture. ( Abdelaziz, AB; Cherif, R; Chettaoui, O; Kaabachi, O; Kokki, H; Ouezini, R, 2007) |
| "To test the hypothesis that local injection of the N-methyl-D-aspartate (NMDA) receptor antagonist ketamine would significantly attenuate glutamate-evoked masseter mechanical sensitization and muscle pain in healthy young women either taking oral contraceptives (W+OC) or not taking oral contraceptives (W-OC)." | 5.12 | Effect of a peripheral NMDA receptor antagonist on glutamate-evoked masseter muscle pain and mechanical sensitization in women. ( Arendt-Nielsen, L; Cairns, BE; Castrillon, EE; Ernberg, M; Sessle, BJ; Svensson, P; Wang, K, 2007) |
| "Propofol, a commonly used anesthetic, often causes pain on injection." | 5.12 | Painless injection of propofol: pretreatment with ketamine vs thiopental, meperidine, and lidocaine. ( Boker, A; Ertok, E; Saadawy, I, 2007) |
| "The aim of this study was to determine whether the follow-up of pain processing recovery in hyperalgesic fibromyalgia (FM) could be objectively evaluated with brain perfusion ethyl cysteinate dimer single photon computerized tomography (ECD-SPECT) after administration of ketamine." | 5.12 | Follow-up of pain processing recovery after ketamine in hyperalgesic fibromyalgia patients using brain perfusion ECD-SPECT. ( Cammilleri, S; Colavolpe, C; de Laforte, C; Guedj, E; Mundler, O; Niboyet, J, 2007) |
| "The analgesic subanesthetic dose of ketamine significantly reduced the pain scores, and this matched a decrease in activity within brain regions that activate in response to noxious stimuli, in particular, the insular cortex and thalamus." | 5.11 | An investigation to dissociate the analgesic and anesthetic properties of ketamine using functional magnetic resonance imaging. ( Longe, SE; Painter, DJ; Rogers, R; Tracey, I; Wise, RG, 2004) |
| "Ketamine but not lidocaine showed a significant analgesic effect in patients with neuropathic pain after spinal cord injury." | 5.11 | The analgesic effect of intravenous ketamine and lidocaine on pain after spinal cord injury. ( Gordh, T; Karlsten, R; Kvarnström, A; Quiding, H, 2004) |
| "This is the first experimental study in humans to find synergistic analgesic effects with coadministration of the N-methyl-D-aspartate receptor antagonist ketamine and morphine on pain involving central sensitization phenomena." | 5.11 | The synergistic effect of combined treatment with systemic ketamine and morphine on experimentally induced windup-like pain in humans. ( Schulte, H; Segerdahl, M; Sollevi, A, 2004) |
| "Midazolam/ketamine sedation has been used successfully in children undergoing painful invasive procedures." | 5.11 | Inter- and intraindividual variability in ketamine dosage in repetitive invasive procedures in children with malignancies. ( Aliani, S; Gottschling, S; Graf, N; Meyer, S, 2004) |
| "Small-dose of ketamine does not seem to be a useful adjunct to remifentanil-based anaesthesia during short, painful surgical procedures." | 5.11 | Ketamine does not decrease postoperative pain after remifentanil-based anaesthesia for tonsillectomy in adults. ( Lebrun, T; Polin, B; Sandefo, I; Van Elstraete, AC, 2004) |
| "Conscious sedation with rectally applied S(+)-ketamine and Midazolam allows safe and painless dressing changes after heat injuries in children." | 5.11 | Conscious sedation: Off-label use of rectal S(+)-ketamine and midazolam for wound dressing changes in paediatric heat injuries. ( Heinrich, M; Muensterer, OJ; Till, H; Wetzstein, V, 2004) |
| " Fentanyl also may reduce the pain of diazepam injection by blocking the opiate receptors in vessels walls." | 5.11 | The effect of ketamine and fentanyl in reducing the pain of diazepam injection. ( Azemati, M; Azemati, S; Khosravi, A; Khosravi, MB, 2004) |
| ") ketamine sedation administered by nonanesthetist physicians for painful procedures." | 5.11 | Intravenous ketamine sedation for painful oncology procedures. ( Barbour, K; Evans, D; Kobe, J; Montgomery, CJ; Rogers, P; Turnham, L; Vandebeek, C; Wilson, L, 2005) |
| "This prospective, double-blind, randomized, placebo-controlled study compares the effects of ephedrine and ketamine on injection pain, and hypotension from propofol." | 5.11 | Comparison of ephedrine and ketamine in prevention of injection pain and hypotension due to propofol induction. ( Altunkaya, H; Ayoğlu, H; Ciçek, E; Demirel, CB; Ozer, Y; Ozkoçak, I, 2005) |
| "We evaluated whether preadministration of low-dose ketamine could attenuate tourniquet pain and arterial pressure increase using high tourniquet pressure in ten healthy awake volunteers." | 5.11 | Preadministration of low-dose ketamine reduces tourniquet pain in healthy volunteers. ( Fukusaki, M; Kanaide, M; Matsumoto, S; Sumikawa, K; Takada, M; Terao, Y; Yamashita, K, 2005) |
| "A double-blind, randomized, placebo-controlled 3-week study evaluated the efficacy of topical 2% amitriptyline, 1% ketamine, and a combination of both in treating patients with neuropathic pain." | 5.11 | Topical 2% amitriptyline and 1% ketamine in neuropathic pain syndromes: a randomized, double-blind, placebo-controlled trial. ( Clark, AJ; Lynch, ME; Sawynok, J; Sullivan, MJ, 2005) |
| "The aim of the present study was to clarify the neurophysiological changes associated with analgesic and behavioral effects of low-dose ketamine HCl in patients suffering from chronic neuropathic pain." | 5.10 | Effects of low-dose ketamine on neuropathic pain: An electroencephalogram-electrooculogram/behavioral study. ( Kato, J; Kojima, T; Matsuura, M; Nagashima, M; Oga, K; Ogawa, S; Saeki, S, 2002) |
| "The incidence of pain of the infusion was significantly lower in patients pretreated with ketamine (8% vs 37%, P = 0." | 5.10 | Pretreatment with intravenous ketamine reduces propofol injection pain. ( Barbi, E; Gagliardo, A; Gerarduzzi, T; Marchetti, F; Neri, E; Sarti, A; Ventura, A, 2003) |
| "The purpose of this study was to evaluate the effect of pre-treatment with ketamine on the reduction of pain during injection of propofol in adult patients." | 5.10 | [Pre-treatment with ketamine reduces incidence and severity of pain on propofol injection]. ( Kumazawa, T; Masamune, T; Nonaka, A; Suzuki, S, 2002) |
| "The aim of this study was to assess the efficacy of dextromethorphan and ketamine relative to placebo on the acute nociceptive threshold and wind-up of second pain response in healthy male volunteers." | 5.10 | Assessment of the effect of dextromethorphan and ketamine on the acute nociceptive threshold and wind-up of the second pain response in healthy male volunteers. ( Fisher, G; Growcott, JW; Hughes, AM; Rhodes, J; Sellers, M, 2002) |
| "We examined the role of N-methyl-D-aspartate (NMDA) receptors in chronic (pathological) pain in humans by using the NMDA receptor antagonist ketamine as a probe." | 5.09 | Prolonged analgesic effect of ketamine, an N-methyl-D-aspartate receptor inhibitor, in patients with chronic pain. ( Oye, I; Rabben, T; Skjelbred, P, 1999) |
| "Ketamine is a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist used recently for analgesia in patients with chronic pain." | 5.09 | Clinical experience with oral ketamine. ( Enarson, MC; Hays, H; Woodroffe, MA, 1999) |
| "Anecdotal reports suggest that the general anaesthetic drug ketamine, taken orally in low doses, can give rise to some extra analgesia in patients with refractory neuropathic pain." | 5.09 | N of 1 randomised controlled trials of oral ketamine in patients with chronic pain. ( Gaines, SP; Haines, DR, 1999) |
| " We showed that, as in animals, this phenomenon, which might represent an elementary form of the central sensitization involved in various painful syndromes, depends on the activation of N-methyl-D-aspartate receptors, because it was selectively reduced after the administration of ketamine." | 5.09 | The effects of ketamine on the temporal summation (wind-up) of the R(III) nociceptive flexion reflex and pain in humans. ( Bouhassira, D; Brasseur, L; Chauvin, M; Dupont, X; Guirimand, F, 2000) |
| "To assess the suitability of ketamine for relief of pain caused by tracheal suction during ventilator treatment in newborn infants." | 5.09 | Ketamine for procedural pain relief in newborn infants. ( Fellman, V; Huttunen, P; Neuvonen, PJ; Saarenmaa, E, 2001) |
| "Pain intensity, muscle strength, static muscle endurance, pressure pain threshold, and pain tolerance at tender points and control points were assessed in 31 patients with fibromyalgia (FM), before and after intravenous administration of morphine (9 patients), lidocaine (11 patients), and ketamine (11 patients)." | 5.08 | Pain analysis in patients with fibromyalgia. Effects of intravenous morphine, lidocaine, and ketamine. ( Bäckman, E; Bengtsson, A; Bengtsson, M; Henriksson, KG; Sörensen, J, 1995) |
| " A few small studies in patients have suggested that intravenous boluses or rapid infusions of the N-methyl-D-aspartate (NMDA) antagonist ketamine relieve some neuropathic pains but also produce disturbances of cognition and mood." | 5.08 | Intravenous infusion of the NMDA antagonist, ketamine, in chronic posttraumatic pain with allodynia: a double-blind comparison to alfentanil and placebo. ( Bennett, GJ; Byas-Smith, MG; Gracely, RH; Max, MB, 1995) |
| "Ketamine has been administered epidurally and intrathecally for operative and post-operative pain control." | 5.08 | Intrathecal ketamine reduces morphine requirements in patients with terminal cancer pain. ( Chang, JY; Ho, ST; Wong, CS; Yang, CY, 1996) |
| "Ten patients (4 female, 6 male) aged 34-67 years suffering from peripheral neuropathic pain participated in a double-blind placebo-controlled study where ketamine or magnesium chloride were administered by a 10 min bolus infusion (ketamine: 0." | 5.08 | NMDA receptor blockade in chronic neuropathic pain: a comparison of ketamine and magnesium chloride. ( Arendt-Nielsen, L; Felsby, S; Jensen, TS; Nielsen, J, 1996) |
| "Ketamine-a clinical available NMDA receptor antagonist-was administered intravenously to a patient with established stump pain in a double-blind saline-controlled fashion." | 5.08 | Oral ketamine therapy in the treatment of postamputation stump pain. ( Hansen, PO; Jensen, TS; Nikolajsen, L, 1997) |
| "In an attempt to clarify the neurochemical background of central post-stroke pain and to undertake a pharmacological analysis, the basic pharmacological characteristics of this intractable pain syndrome were investigated by the morphine, thiamylal and ketamine tests." | 5.08 | Pharmacological classification of central post-stroke pain: comparison with the results of chronic motor cortex stimulation therapy. ( Hirayama, T; Katayama, Y; Tsubokawa, T; Yamamoto, T, 1997) |
| "9% saline (1 ml) on propofol injection pain." | 5.08 | The effect of ketamine pretreatment on propofol injection pain in 100 women. ( Kua, SW; Onsiong, MK; Tan, CH, 1998) |
| "In a double-blind, controlled trial, we administered doses of an opioid analgesic (alfentanil), an N-methyl-D-aspartate receptor antagonist (ketamine), or their combination to normal volunteers and found no advantage of the combination over a larger dose of either drug alone in relieving pain caused by painful chemical stimulation." | 5.08 | Analgesic and cognitive effects of intravenous ketamine-alfentanil combinations versus either drug alone after intradermal capsaicin in normal subjects. ( Bennett, GJ; Gracely, R; Liu, M; Max, MB; Sethna, NF, 1998) |
| " This study examined the analgesic effect of local ketamine infiltration, compared with placebo and systemic ketamine, in a human model of inflammatory pain." | 5.08 | Peripheral analgesic effects of ketamine in acute inflammatory pain. ( Galle, TS; Kehlet, H; Pedersen, JL, 1998) |
| "Ketamine in sub-dissociative doses has been shown to have analgesic effects in various pain conditions, including neuropathic and phantom-limb pain, where conventional treatment has often failed." | 5.08 | The analgesic effect of racemic ketamine in patients with chronic ischemic pain due to lower extremity arteriosclerosis obliterans. ( Gustafsson, LL; Hasselström, J; Heller, A; Persson, J; Svensson, JO; Wiklund, B, 1998) |
| "The analgesic efficiency of ketamine and pethidine was compared in experimental ischemic pain and postoperative pain after oral surgery." | 5.06 | Comparison of ketamine and pethidine in experimental and postoperative pain. ( Hustveit, O; Maurset, A; Skoglund, LA; Øye, I, 1989) |
| "Intravenous ketamine is commonly used for pain management in the civilian prehospital setting." | 5.05 | Use of ketamine for prehospital pain control on the battlefield: A systematic review. ( Cauet, A; de Rocquigny, G; Dubecq, C; Martinez, T; Pasquier, P; Peffer, J; Travers, S, 2020) |
| " We present this case of a 34-year-old female patient who suffered an 18% total body surface area burn during the third trimester of pregnancy to demonstrate that ketamine can be considered as an adjunct for procedural and background analgesia during the third trimester, as part of a multimodal strategy in a short-term, monitored setting after a thorough and complete analysis of risks and benefits and careful patient selection." | 5.05 | Meeting the Challenge of Analgesia in a Pregnant Woman With Burn Injury Using Subanesthetic Ketamine: A Case Report and Literature Review. ( Elkhashab, Y; Hughes, LP; Hughes, MK; Hughes, WB; Roy, AB; Schwenk, ES; Viscusi, ER; West, LA, 2020) |
| " Ketamine, a N-methyl D-aspartate (NMDA) receptor antagonist, has been commonly used in the prehospital setting, including recommendations by the US Department of Defense and by the Royal Australian College of Pain Medicine, despite the paucity of high-level evidence." | 5.05 | Ketamine as a Prehospital Analgesic: A Systematic Review. ( Bansal, A; Burns, B; Ferguson, I; Miller, M, 2020) |
| "Ketamine is regaining popularity in the field of anesthesia and beyond." | 5.05 | Ketamine: a versatile tool for anesthesia and analgesia. ( Barrett, W; Buxhoeveden, M; Dhillon, S, 2020) |
| "Subanesthetic ketamine doses rapidly, albeit transiently decrease suicidal ideation, with effects emerging within an hour and persisting up to a week." | 5.01 | Suicide Has Many Faces, So Does Ketamine: a Narrative Review on Ketamine's Antisuicidal Actions. ( Courtet, P; Lengvenyte, A; Olié, E, 2019) |
| "Low-dose ketamine infusions for pediatric patients with sickle cell disease painful crises resulted in improved pain scores and reduced opioid usage." | 5.01 | Ketamine Infusion for Pain Control in Acute Pediatric Sickle Cell Painful Crises. ( Hagedorn, JM; Monico, EC, 2019) |
| "In this review, we examined basic mechanisms of ketamine and its current clinical use and potential novel use in pain management." | 4.98 | An Update on the Basic and Clinical Science of Ketamine Analgesia. ( Doan, LV; Wang, J, 2018) |
| "The purpose of this review is to integrate a number of basic science, preclinical, and clinical studies with the goal of providing insight into the possible signaling events underlying ketamine's biological effects in pain management, depression, cognition and memory, and neurodevelopment." | 4.95 | Ketamine: An Update on Cellular and Subcellular Mechanisms with Implications for Clinical Practice. ( Iacobucci, GJ; Nader, ND; Pourafkari, L; Visnjevac, O, 2017) |
| " All randomized controlled trials that using lidocaine for propofol injection pain in children were enrolled." | 4.95 | Efficacy of lidocaine on preventing incidence and severity of pain associated with propofol using in pediatric patients: A PRISMA-compliant meta-analysis of randomized controlled trials. ( Fu, YZ; Lang, BC; Yang, CS; Zhang, LL; Zhang, WS, 2017) |
| "After nearly half a century on the market, ketamine still occupies a unique corner in the medical armamentarium of anesthesiologists or clinicians treating pain." | 4.93 | Ketamine use in current clinical practice. ( Gao, M; Liu, H; Rejaei, D, 2016) |
| "This article reports a rare case of the use of low-dose ketamine infusion as an adjuvant to opioids to treat pain in sickle cell disease." | 4.90 | Ketamine infusion for sickle cell pain crisis refractory to opioids: a case report and review of literature. ( Baber, A; Foy, M; Uprety, D, 2014) |
| "The role of ketamine anesthesia in the prehospital, emergency department and operating theater settings is not well defined." | 4.89 | Ketamine: use in anesthesia. ( Andolfatto, G; Brandner, B; Ellerton, J; Marland, S; Paal, P; Strapazzon, G; Thomassen, O; Weatherall, A, 2013) |
| "For ketamine's fiftieth birthday, a narrative review of this unique drug in pain management is presented." | 4.89 | Ketamine in pain management. ( Persson, J, 2013) |
| " Ketamine is a commonly used anaesthetic agent, and in subanaesthetic doses is also given as an adjuvant to opioids for the treatment of cancer pain, particularly when opioids alone prove to be ineffective." | 4.88 | Ketamine as an adjuvant to opioids for cancer pain. ( Bell, RF; Eccleston, C; Kalso, EA, 2012) |
| "To assess the current literature regarding the effectiveness and side-effect profile of intravenous ketamine as a means of pain relief when compared with placebo or as an adjunct to opioid analgesia in patients exposed to burn injury." | 4.87 | A systematic review of ketamine as an analgesic agent in adult burn injuries. ( Cleland, H; Hogan, L; Hucker, T; Mahar, PD; McGuinness, SK; Symons, J; Wasiak, J, 2011) |
| "While most studies on intravenous ketamine show acute analgesic effects, three recent trials on long-term ketamine treatment (days to weeks) demonstrate the effectiveness of ketamine in causing long-term (months) relief of chronic pain." | 4.86 | Ketamine for the treatment of chronic non-cancer pain. ( Aarts, L; Dahan, A; Niesters, M; Noppers, I; Sarton, E; Smith, T, 2010) |
| "Multimodal therapy encompasses a wide range of procedures and medications, including regional analgesia with continuous epidural or peripheral nerve block infusions, judicious opioids, acetaminophen, anti-inflammatory agents, anticonvulsants, ketamine, clonidine, mexiletine, antidepressants, and anxiolytics as options to treat or modulate pain at various sites of action." | 4.84 | The evolution of pain management in the critically ill trauma patient: Emerging concepts from the global war on terrorism. ( Black, IH; Malchow, RJ, 2008) |
| " Alternative approaches with methadone, ketamine, or local anesthetics should be considered." | 4.84 | Pharmacological approaches to the management of pain in the neonatal intensive care unit. ( Anand, KJ, 2007) |
| " Search terms included analgesia, cancer pain, dextromethorphan, hospice, ketamine, opioids, palliative care, neuropathic pain, and morphine." | 4.83 | The potential role of ketamine in hospice analgesia: a literature review. ( Ball, N; Elliott, DP; Legge, J, 2006) |
| "Ketamine is a commonly used anaesthetic agent, and in subanaesthetic doses is also given as an adjuvant to opioids for the treatment of cancer pain, particularly when opioids alone prove to be ineffective." | 4.82 | Ketamine as an adjuvant to opioids for cancer pain. ( Bell, R; Eccleston, C; Kalso, E, 2003) |
| "Ketamine is increasingly being used as an adjuvant to opioids in the treatment of refractory cancer pain." | 4.82 | Ketamine as adjuvant to opioids for cancer pain. A qualitative systematic review. ( Bell, RF; Eccleston, C; Kalso, E, 2003) |
| "Ketamine has diverse effects that may be of relevance to chronic pain including: N-methyl-D-aspartic acid, alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid, kainate, gamma-aminobutyric acid(A) receptors; inhibition of voltage gated Na(+) and K(+) channels and serotonin, dopamine re-uptake." | 4.82 | Ketamine in chronic pain management: an evidence-based review. ( Cousins, MJ; Hocking, G, 2003) |
| " Evidence presented in this review shows encouraging results following the administration of methadone, fentanyl or ketamine to patients with difficult pain problems." | 4.82 | Morphine is not the only analgesic in palliative care: literature review. ( Wootton, M, 2004) |
| "Ketamine is an effective analgesic agent for treating a variety of neuropathic and cancer pain syndromes." | 4.82 | Parenteral ketamine as an analgesic adjuvant for severe pain: development and retrospective audit of a protocol for a palliative care unit. ( Fitzgibbon, EJ; Viola, R, 2005) |
| "To review the clinical literature evaluating the utilization of intravenous ketamine for the management of cancer-related pain, to summarize the data that suggest ketamine is an appropriate adjuvant method of providing analgesia and to report a case of successful pain management using ketamine in a patient with recurrent testicular cancer at our institution." | 4.81 | Adjuvant ketamine analgesia for the management of cancer pain. ( Baroletti, SA; McQueen, AL, 2002) |
| " In the majority of clinical studies addressing this issue, ketamine, which has NMDA antagonist properties, has been found to reduce the need for opiates for the treatment of severe pain conditions." | 4.80 | Combined opioid-NMDA antagonist therapies. What advantages do they offer for the control of pain syndromes? ( Wiesenfeld-Hallin, Z, 1998) |
| "We report the initial seven patients treated with nebulized ketamine for moderate to severe pain, via breath-actuated nebulizer, in an urban, ground-based emergency medical services (EMS) system." | 4.31 | Nebulized Ketamine for Analgesia in the Prehospital Setting: A Case Series. ( De La Rosa, X; Patrick, C; Rafique, Z; Rogers Keene, K; Smith, M, 2023) |
| "Ketamine infusions are frequently employed for refractory complex regional pain syndrome (CRPS), but there are limited data on factors associated with treatment response." | 4.31 | Sympathetic Blocks as a Predictor for Response to Ketamine Infusion in Patients with Complex Regional Pain Syndrome: A Multicenter Study. ( Cheng, J; Cohen, SJ; Cohen, SP; Khunsriraksakul, C; Moon, JY; Parker, E; Patel, N; Samen-Akinsiku, CDK; Yoo, Y; Yuan, X, 2023) |
| "Depressive symptom severity and the affective index of pain partially mediated improvements in social function after six repeated ketamine treatments among patients with bipolar or unipolar depressive disorder." | 4.31 | Pain mediates the improvement of social functions of repeated intravenous ketamine in patients with unipolar and bipolar depression. ( Gan, Y; Hu, Z; Lan, X; Li, N; Li, W; Liu, H; Ning, Y; Wang, C; Wu, Z; Ye, Y; Zhang, F; Zhou, Y, 2023) |
| "Outcomes were the recording of a pain score and the administration of a nonoral opioid or ketamine." | 4.31 | Race and Ethnicity and Prehospital Use of Opioid or Ketamine Analgesia in Acute Traumatic Injury. ( Brunson, DC; Carrillo, E; Matheson, LW; Miller, KA, 2023) |
| "Intrathecal 2R, 6R-HNK, rather than intraperitoneal 2R, 6R-HNK or intrathecal S-Ketamine, successfully mitigated HFS-induced pain." | 4.31 | The potent analgesia of intrathecal 2R, 6R-HNK via TRPA1 inhibition in LF-PENS-induced chronic primary pain model. ( Feng, X; Li, Y; Lin, ZJ; Liu, AR; Peng, XG; Tan, Z; Tang, Y; Wei, M; Zhang, H; Zheng, YF; Zhou, LJ, 2023) |
| "Following recognition of opioid induced hyperalgesia, the patient was managed with opioid rotation and ketamine, which resulted in prompt alleviation of pain." | 4.12 | Role of Ketamine and Opioid Rotation in the Management of Opioid Induced Hyperalgesia in a Patient With Acute Promyelocytic Leukemia. ( Akhtari, M; Cao, H; Hino, C; Ran-Castillo, D; Silvestre, J, 2022) |
| "The objective of our study was to determine safety and pharmacology (pharmacokinetics and preliminary efficacy) of intranasal (IN) ketamine for uncontrolled cancer-related pain." | 4.12 | A dose-escalation clinical trial of intranasal ketamine for uncontrolled cancer-related pain. ( Beumer, JH; Curseen, K; Egan, K; Gillespie, TW; Harvey, RD; Lane, O; Shteamer, JW; Singh, V; Sniecinski, R; Spektor, B; Switchenko, J; Tsvetkova, M; Zarrabi, AJ, 2022) |
| "To report on an unusual case of ketamine-precipitated syndrome of inappropriate antidiuretic hormone secretion (SIADH) in an individual managed by an outpatient pain specialty team." | 4.12 | Ketamine-precipitated syndrome of inappropriate antidiuretic hormone secretion in a patient with persistent lumbar pain: a case report. ( Lau, A; van Bockxmeer, JJ; Varshney, V, 2022) |
| "Psychological pain and hopelessness were not associated with the re-emergence of SI post-ketamine." | 4.12 | Prospective association of psychological pain and hopelessness with suicidal thoughts. ( Ballard, ED; Bloomfield-Clagett, B; Farmer, CA; Gerner, J; Park, LT; Zarate, CA, 2022) |
| "Our aim was to evaluate the quality and safety of procedural sedation using the combination of dexmedetomidine and ketamine for patients undergoing painful procedures in the emergency department." | 4.12 | Procedural Sedation With Dexmedetomidine in Combination With Ketamine in the Emergency Department. ( Cren, R; De Kock, M; Grégoire, C; Henrie, J; Lavand'homme, P; Penaloza, A; Verschuren, F, 2022) |
| " Inclusion criteria were 16 years or older, two or more documented pain assessments, at least one indicating severe pain, and administration of opioids and/or low-dose ketamine." | 4.12 | Opioid sparing effect of ketamine in military prehospital pain management-A retrospective study. ( Avital, G; Benov, A; Cohen, B; Gelikas, S; Kontorovich-Chen, D; Radomislensky, I; Talmy, T, 2022) |
| "This article provides a comprehensive discussion of ketamine's pharmacological properties, safety profile, and an overview of current evidence for ketamine in the management of ED patients with acute agitation, pain, depression/suicide ideation." | 4.12 | Novel uses of ketamine in the emergency department. ( Corwell, BN; Davis, NL; Kim, HK; Motov, SM, 2022) |
| " His pain and agitation were difficult to manage but improved after he received ketamine." | 4.12 | Suspected opioid-induced hyperalgesia in an infant following surgery: A case report. ( Efune, PN; Rebstock, SE, 2022) |
| " However, to the best of our knowledge, no study has reported on endotracheal intubation without the use of muscle relaxants under anesthetic management with remimazolam, nor on the combination of remimazolam and ketamine." | 4.12 | Effective anesthetic management with remimazolam and ketamine without muscle relaxants for parotidectomy in a patient with myotonic dystrophy: A case report. ( Habu, MI; Ishida, Y; Toba, Y, 2022) |
| " Additionally, dissociative sedation ketamine for severe agitation/excited delirium led to less endotracheal intubation than reported in the prehospital literature." | 3.96 | Ketamine Safety and Use in the Emergency Department for Pain and Agitation/Delirium: A Health System Experience. ( Campbell, MJ; Casserly, E; Fertel, BS; Lam, SW; Meldon, SW; Mo, H; Wells, EJ, 2020) |
| "Sprague-Dawley rats (11-13 weeks) were randomly assigned to control (saline vehicle), fentanyl, or ketamine-treated groups with or without hemorrhage (n = 8 or 9 for each group)." | 3.96 | Fentanyl impairs but ketamine preserves the microcirculatory response to hemorrhage. ( Calderon, AS; Hinojosa-Laborde, C; Klemcke, HG; Ryan, KL; Scott, LL; Xiang, L, 2020) |
| " Ketamine can quickly relieve depression, and its subcutaneous administration appears to be as effective as and probably safer than its standard intravenous administration." | 3.96 | Repeated subcutaneous esketamine administration for depressive symptoms and pain relief in a terminally ill cancer patient: A case report. ( Barbosa, MG; Delfino, RS; Jackowski, AP; Sarin, LM, 2020) |
| "Low doses of ketamine have been shown to be safe and effective for pain relief." | 3.96 | Transient amnesia following prehospital low-dose ketamine administration. ( Aljadeed, R; Perona, S, 2020) |
| " Ketamine is on the WHO's list of essential medications and is used for a variety of pharmacologic applications including anesthesia and acute pain management." | 3.96 | Ketamine for pain control of snake envenomation in Guinea: A case series. ( Balde, C; Benjamin, JM; Brandehoff, N; Chippaux, JP, 2020) |
| "Ketamine is beneficial in clinical settings ranging from procedural sedation to the treatment of chronic pain." | 3.96 | Ketamine for Acute Pain Management and Sedation. ( Brown, K; Tucker, C, 2020) |
| "The results of the present study suggest that serotonergic and opioidergic systems are involved, at least in part, in the antinociceptive effect of the ketamine-magnesium sulphate combination in the model of inflammatory pain in rats." | 3.91 | Involvement of serotonergic and opioidergic systems in the antinociceptive effect of ketamine-magnesium sulphate combination in formalin test in rats. ( Divac, N; Medić, B; Prostran, M; Savić Vujović, K; Srebro, D; Stojanović, R; Vasović, D; Vučković, S, 2019) |
| "Ketamine is a drug largely used in clinical practice as an anesthetic and it can also be used as an analgesic to manage chronic pain symptoms." | 3.91 | Peripheral antinociception induced by ketamine is mediated by the endogenous opioid system. ( Caliari, MV; de Almeida, DL; Duarte, IDG; Lima Romero, TR; Paiva-Lima, P; Petrocchi, JA; Queiroz-Junior, C, 2019) |
| " Ketamine, acknowledged for its versatility and safety profile, remains a critical component in the medical arsenal of anaesthesiologists and clinicians treating both acute and chronic pain." | 3.91 | The ketamine crisis: Does South Africa have a plan B? ( Bangalee, V; Wall, S, 2019) |
| "Therapeutic interventions for neuropathic pain, such as the N-methyl-D-aspartate (NMDA) antagonist ketamine, can vary widely in effectiveness." | 3.91 | Plasticity in the dynamic pain connectome associated with ketamine-induced neuropathic pain relief. ( Bhatia, A; Bosma, RL; Cheng, JC; Davis, KD; Hemington, KS; Kim, JA; Osborne, NR; Rogachov, A; Venkatraghavan, L, 2019) |
| "To examine the analgesic effects of adjuvant ketamine on pain scale scores in trauma intensive care unit (ICU) rib fracture." | 3.88 | Ketamine as an Analgesic Adjuvant in Adult Trauma Intensive Care Unit Patients With Rib Fracture. ( Bischoff, J; Evans, C; Farhat, J; Foss, M; Walters, MK, 2018) |
| "Although ketamine analgesia is effective in reducing pain and facilitating the tracheal intubation of newborns in the delivery room, no data on the neurological effects of this treatment are available." | 3.88 | Prospective follow-up of a cohort of preterm infants<33 WG receiving ketamine for tracheal intubation in the delivery room: Neurological outcome at 1 and 2 years. ( Elalouf, C; Fontaine, C; Gondry, J; Kongolo, G; Le Moing, AG; Leke, A; Tourneux, P, 2018) |
| "Our objective was to describe dosing, duration, and pre- and post-infusion analgesic administration of continuous intravenous sub-dissociative dose ketamine (SDK) infusion for managing a variety of painful conditions in the emergency department (ED)." | 3.88 | Continuous Intravenous Sub-Dissociative Dose Ketamine Infusion for Managing Pain in the Emergency Department. ( Beals, T; Drapkin, J; Fromm, C; Likourezos, A; Marshall, J; Monfort, R; Motov, S, 2018) |
| "WHAT THIS ARTICLE TELLS US THAT IS NEW: BACKGROUND:: Ketamine is an N-methyl-D-aspartate receptor antagonist that reduces temporal summation of pain and modulates antinociception." | 3.88 | Brain Dynamics and Temporal Summation of Pain Predicts Neuropathic Pain Relief from Ketamine Infusion. ( Bhatia, A; Bosma, RL; Cheng, JC; Davis, KD; Hemington, KS; Kim, JA; Osborne, NR; Rogachov, A; Venkat Raghavan, L, 2018) |
| "The study evaluated the effect of intra-articular injections of ketamine and 25% dextrose with triamcinolone acetate (TA) and hyaluronic acid (HA) on joint pathology and pain behavior in monosodium iodoacetate (MIA)-induced osteoarthritis (OA) in experimental mice." | 3.85 | Intra-articular injections of ketamine and 25% dextrose improve clinical and pathological outcomes in the monosodium iodoacetate model of osteoarthritis. ( Brahma, S; Jalgaonkar, SV; Koli, PG; Kshirsagar, S; Patil, AE; Rege, NN; Salgaonkar, S; Shetty, YC; Teltumbde, PA, 2017) |
| "Because ketamine and magnesium block NMDA receptor activation by distinct mechanisms of action, we hypothesized that in a model of inflammatory pain in rats the combination of ketamine and magnesium might be more effective than ketamine alone." | 3.85 | Additive and antagonistic antinociceptive interactions between magnesium sulfate and ketamine in the rat formalin test. ( Knežević, N; Medić, B; Prostran, M; Vasović, D; Vučković, S; Vujović, KS, 2017) |
| "We report a case series on the observed effects of low-dose ketamine infusions in 4 critically ill patients with varying complications related to prolonged critical illness." | 3.83 | Low-Dose Ketamine in Chronic Critical Illness. ( Darrah, D; Moitra, A; Moitra, VK; Patel, MK; Wunsch, H, 2016) |
| "This study compared effects of the NMDA receptor antagonists ketamine and MK-801 in assays of pain-stimulated and pain-depressed behaviour in rats." | 3.83 | Effects of the noncompetitive N-methyl-d-aspartate receptor antagonists ketamine and MK-801 on pain-stimulated and pain-depressed behaviour in rats. ( Hillhouse, TM; Negus, SS, 2016) |
| "Changes in visual analog scale (VAS) scores for pain following pharmacological evaluation using morphine, thiopental, and ketamine were compared with those following SCS in 22 CPSP patients." | 3.83 | Importance of Pharmacological Evaluation in the Treatment of Poststroke Pain by Spinal Cord Stimulation. ( Fukaya, C; Kano, T; Kobayashi, K; Obuchi, T; Oshima, H; Watanabe, M; Yamamoto, T; Yoshino, A, 2016) |
| "Intravenous ketamine treatment is frequently used for the management of chronic pain, especially in those patients who do not benefit from other therapies." | 3.83 | [Safety and efficacy of ketamine for pain relief]. ( Dahan, A; Niesters, M; van Kleef, M, 2016) |
| "Immunoglobulin E, ketamine cystitis, interstitial cystitis." | 3.83 | The Role of Immunoglobulin E in the Pathogenesis of Ketamine Related Cystitis and Ulcerative Interstitial Cystitis: An Immunohistochemical Study. ( Hsu, YH; Jhang, JF; Jiang, YH; Kuo, HC, 2016) |
| "The objective of this systematic review is to examine the best available evidence on the clinical effectiveness of ketamine as an adjuvant to opioid-based therapy versus opioid-based therapy alone in decreasing perioperative pain associated with opioid tolerance in adult patients, aged 18-70 years, undergoing orthopedic surgical procedures." | 3.83 | Effectiveness of ketamine as an adjuvant to opioid-based therapy in decreasing pain associated with opioid tolerance in adults undergoing orthopedic surgery: a systematic review protocol. ( Bennett, M; Bonanno, L; Kuhn, W, 2016) |
| "A low-dose ketamine infusion protocol provided significant pain relief with mostly mild side effects and no severe adverse events." | 3.81 | Low-Dose Ketamine Infusion for Emergency Department Patients with Severe Pain. ( Ahern, TL; Frazee, BW; Herring, AA; Miller, S, 2015) |
| "Midazolam and ketamine were administered consecutively by intravenous route under cardiorespiratory monitoring for painful procedures of pediatric hematology." | 3.81 | The Efficacy and Safety of Procedural Sedoanalgesia with Midazolam and Ketamine in Pediatric Hematology. ( Çakmak, E; Demirsoy, U; Gelen, SA; Sarper, N; Zengin, E, 2015) |
| "This study revealed that (1) magnesium sulphate and ketamine given alone were not effective against acute nociceptive pain in rats, but (2) a combination of both drugs resulted in synergistically inhibited nociception, (3) which occurred only at selected low doses and proportions of the medications in a combination and (4) suggested the importance of the order of drug administration." | 3.81 | A synergistic interaction between magnesium sulphate and ketamine on the inhibition of acute nociception in rats. ( Medic, B; Prostran, M; Savic Vujovic, KR; Srebro, D; Stojanovic, R; Vucetic, C; Vuckovic, S, 2015) |
| "Before updating the French guidelines on postoperative pain treatment in 2015, the Pain Committee of the French Society of Anaesthesiology and Intensive Care (SFAR) conducted a survey on the medical use of ketamine in France." | 3.81 | Ketamine for pain management in France, an observational survey. ( Beloeil, H; Derivaux, B; Martinez, V, 2015) |
| "We studied the role of a low-dose intravenous (IV) ketamine-midazolam combination in the management of severe painful sickle cell crisis." | 3.80 | The role of a low-dose ketamine-midazolam regimen in the management of severe painful crisis in patients with sickle cell disease. ( Faris, AS; Kausalya, R; Tawfic, QA, 2014) |
| "Ketamine, a noncompetitive N-methyl-D-aspartate receptor antagonist, has been used for the treatment of cancer pain as an analgesic adjuvant to opioids." | 3.80 | Subanalgesic ketamine enhances morphine-induced antinociceptive activity without cortical dysfunction in rats. ( Goda, Y; Goto, Y; Hiraide, S; Kamiyama, H; Kiya, T; Oda, K; Shikanai, H; Shimamura, K; Togashi, H; Yanagawa, Y, 2014) |
| "In this retrospective study, the medical records of 50 patients hospitalized on medical and surgical units at our facility who had continuous intravenous infusions of ketamine for pain or mild sedation were reviewed." | 3.80 | Psychiatric side effects of ketamine in hospitalized medical patients administered subanesthetic doses for pain control. ( Rasmussen, KG, 2014) |
| "Examine response patterns to low-dose intravenous (IV) ketamine continuous infusions on multiple pain outcomes, and demonstrate effectiveness, safety, and tolerability of ketamine administration on general wards." | 3.79 | Effects of low-dose IV ketamine on peripheral and central pain from major limb injuries sustained in combat. ( Buckenmaier, CC; Gallagher, RM; Goldberg, C; Hanlon, AL; Kwon, KH; Polomano, RC; Rupprecht, C, 2013) |
| "Ketamine 100 ng/ml exerts its effect on pain related brain regions." | 3.79 | [Effect of subanaesthetic dose of ketamine on mechanical stimulus on brain regions]. ( Sun, L; Wang, HY; Xu, L; Ye, TH; Yuan, H; Zou, L, 2013) |
| "Low-dose ketamine may decrease patients' perception of pain." | 3.79 | Low-dose ketamine analgesia: patient and physician experience in the ED. ( Richards, JR; Rockford, RE, 2013) |
| "We report the successful use of low-dose ketamine infusion for treating a severe episode of painful myoclonus in the lower extremities, associated with opioid-induced hyperalgesia (OIH), in a patient who was receiving long-term, high dose intrathecal hydromorphone therapy." | 3.78 | Successful reversal of hyperalgesia/myoclonus complex with low-dose ketamine infusion. ( Chan, PS; Forero, M; Restrepo-Garces, CE, 2012) |
| "Injection anaesthesia with a combination of ketamine and azaperone (K/A) is discussed as a painless alternative to commonly used non-anaesthetized castration." | 3.78 | Impact of general injection anaesthesia and analgesia on post-castration behaviour and teat order of piglets. ( König, A; Schmidt, T; von Borell, E, 2012) |
| "In 24/92 (26%) of cases, morphine PCA provided insufficient pain relief and children required adjuvant ketamine therapy." | 3.77 | Pain management in 100 episodes of severe mucositis in children. ( Hommers, C; Parry, S; Stoddart, PA; White, MC, 2011) |
| "The ketamine pharmacokinetics in children with minor burns are similar to those without burns." | 3.77 | Exploring the pharmacokinetics of oral ketamine in children undergoing burns procedures. ( Anderson, BJ; Brunette, KE; Herd, DW; Schulein, S; Thomas, J; Wiesner, L, 2011) |
| "To investigate the expression of protein kinase C (PKC) in the spinal dorsal horn of rats with formalin-induced pain and the effect of intrathecal ketamine on PKC expression." | 3.77 | [Effect of intrathecal ketamine injection on protein kinase C expression in the spinal dorsal horn of rats with formalin-induced pain]. ( GUO, QL; WANG, E; YAN, JQ; YANG, Y; ZOU, WY, 2011) |
| "Compared to ketamine + no VR, both patients reported less pain during ketamine + VR for all three pain ratings." | 3.77 | Combining ketamine and virtual reality pain control during severe burn wound care: one military and one civilian patient. ( Desocio, PA; Fowler, M; Gaylord, KM; Hoffman, HG; Maani, CV; Maiers, AJ, 2011) |
| "We investigated the heat pain threshold (HPT) and temporal summation threshold (TST) before and after target-controlled infusion (TCI) of ketamine with an effect-site concentration (Ce) of 30 and 60 ng/ml." | 3.77 | The effect of target-controlled infusion of low-dose ketamine on heat pain and temporal summation threshold. ( Chae, WS; Cho, SH; Jin, HC; Kim, SH; Kim, YI; Lee, JH; Lee, JS, 2011) |
| "Ketamine, its active metabolite norketamine, and the NR2B-selective antagonist traxoprodil (CP-101,606) were tested in rat models of acute antinociception (paw-withdrawal response to heat) and chronic neuropathic pain (spared nerve injury)." | 3.77 | Nonselective and NR2B-selective N-methyl-D-aspartic acid receptor antagonists produce antinociception and long-term relief of allodynia in acute and neuropathic pain. ( Aarts, L; Dahan, A; Morariu, A; Niesters, M; Swartjes, M, 2011) |
| "The aim of the study was to explore the analgesic effect of the N-methyl-d-aspartate receptor (NMDAR) antagonist ketamine in acute experimental versus chronic spontaneous pain in Complex Regional Pain Syndrome type 1 (CRPS-1) patients." | 3.76 | An observational study on the effect of S+-ketamine on chronic pain versus experimental acute pain in Complex Regional Pain Syndrome type 1 patients. ( Bauer, M; Dahan, A; Mooren, R; Noppers, I; Olofsen, E; Sarton, E; Sigtermans, M, 2010) |
| "Five children and adolescents received a low-dose ketamine infusion for the treatment of sickle cell-related pain." | 3.76 | Use of low-dose ketamine infusion for pediatric patients with sickle cell disease-related pain: a case series. ( Corsi, JM; Hagstrom, JN; Loiselle, KA; Zempsky, WT, 2010) |
| "Ketamine abusers frequently presented with upper GI symptoms, the commonest of which is epigastric pain (73% of abusers)." | 3.76 | Upper gastrointestinal problems in inhalational ketamine abusers. ( Chan, MY; Chu, SK; Fung, KW; Leung, SK; Man, CW; Poon, TL; Wong, KF; Yiu, MK, 2010) |
| "To assess the efficacy of adding ketamine to morphine nurse- or patient-controlled analgesia (NCA/PCA) infusions in treating mucositis pain in children." | 3.76 | The addition of ketamine to a morphine nurse- or patient-controlled analgesia infusion (PCA/NCA) increases analgesic efficacy in children with mucositis pain. ( Howard, RF; James, PJ; Williams, DG, 2010) |
| "The ketamine (ket) model reflects features of schizophrenia as well as secondary symptoms such as altered pain sensitivity." | 3.75 | Haloperidol and risperidone have specific effects on altered pain sensitivity in the ketamine model of schizophrenia. ( Becker, A; Grecksch, G; Hiemke, C; Ladstaetter, E; Schmitt, U; Zernig, G, 2009) |
| "Although ketamine is widely used as an analgesic agent and has an anti-allodynic effect on neuropathic pain, the underlying analgesic mechanisms are not fully explained by the modern 'neuronal-based' theories." | 3.75 | Inhibiting astrocytic activation: a novel analgesic mechanism of ketamine at the spinal level? ( Li, Y; Mei, X; Wang, W; Wu, S; Xu, L; Zhang, H, 2009) |
| "The purpose of this study was to examine possible peripheral mechanisms for the reduction of propofol injection pain by the addition of ketamine." | 3.75 | Preventing pain on injection of propofol: a comparison between peripheral ketamine pre-treatment and ketamine added to propofol. ( Do, SH; Hwang, J; Jeon, YT; Lee, SC; Lim, YJ; Park, HP, 2009) |
| "To improve opioid repsonse in patients with movement-related pain by using opioid switching adding a burst of ketamine." | 3.75 | Opioid switching and burst ketamine to improve the opioid response in patients with movement-related pain due to bone metastases. ( Arcuri, E; David, F; Ferrera, P; Mercadante, S; Villari, P, 2009) |
| "Our objective was to determine if an oral ketamine swish and expectorate was a safe and effective method to alleviate mucositis pain." | 3.75 | Ketamine mouthwash for mucositis pain. ( Atayee, RS; Lin, F; Ryan, AJ, 2009) |
| "Low-dose ketamine behaves as an analgesic in the treatment of acute and chronic pain." | 3.75 | S(+)-ketamine effect on experimental pain and cardiac output: a population pharmacokinetic-pharmacodynamic modeling study in healthy volunteers. ( Bauer, M; Dahan, A; Kest, B; Mooren, R; Olofsen, E; Sarton, E; Sigtermans, M, 2009) |
| " Since 2005 to 2007, we evaluated the safety and efficacy of ketamine to control pain induced by diagnostic procedures in pediatric oncology patients." | 3.75 | [Sedation using ketamine for pain procedures in Pediatric Oncology.]. ( Bernard, F; Ricard, C; Tichit, R; Troncin, R, 2009) |
| " In the present study, morphine (a low dose) was combined with S(+)- and R(-)-norketamine (sub-antinociceptive doses) and characterized utilizing rodent models of pain including: thermal nociception (the tail-flick test), peripheral neuropathy (chronic constriction nerve injury) and tonic inflammatory pain (the formalin test)." | 3.74 | Interaction between morphine and norketamine enantiomers in rodent models of nociception. ( Crooks, PA; Holtman, JR; Johnson-Hardy, J; Wala, EP, 2008) |
| " The topics addressed are tolerance to opioid side effects, use of botulinum toxin A in pain management, and the use of ketamine in pain management." | 3.74 | European pain management discussion forum. ( Eisenberg, E, 2008) |
| " infusion of propofol, or propofol plus ketamine for deep sedation and analgesia was carried out in two patients with severe epidermolysis bullosa (EB) during extensive dressing changes and deep whirlpool baths." | 3.74 | Deep sedation with intravenous infusion of combined propofol and ketamine during dressing changes and whirlpool bath in patients with severe epidermolysis bullosa. ( Wu, J, 2007) |
| "We report the use of an intravenous ketamine infusion for 37 days in a 9-year-old child with 42% body surface area burns." | 3.74 | Long-term use of an intravenous ketamine infusion in a child with significant burns. ( Karsli, C; White, MC, 2007) |
| "This prospective audit was undertaken in order to document the analgesic response and adverse effects of concurrent short-term ('burst') triple-agent analgesic (ketamine, an opioid and an anti-inflammatory agent--either steroidal or non-steroidal) administration, for episodes of acute on chronic pain." | 3.73 | Prospective audit of short-term concurrent ketamine, opioid and anti-inflammatory ('triple-agent') therapy for episodes of acute on chronic pain. ( Ashby, M; Good, P; Goodchild, C; Jackson, K; Tullio, F, 2005) |
| "Pretreatment with intravenous ketamine inhibits inflammatory pain behavior and FLI expression following a formalin injection in rats, suggesting that pretreatment of ketamine plays an important role in preemptive analgesia." | 3.73 | Preemptive effect of intravenous ketamine in the rat: concordance between pain behavior and spinal fos-like immunoreactivity. ( Lee, IH; Lee, IO, 2005) |
| "Questions have been raised about the potential neurotoxicity of the neuraxial use of ketamine although ketamine and its active enantiomer S(+)-ketamine have been used intrathecally and epidurally (caudally) for the management of perioperative pain and in a variety of chronic pain syndromes." | 3.73 | Neuropathological findings after continuous intrathecal administration of S(+)-ketamine for the management of neuropathic cancer pain. ( Kruis, MR; Troost, D; van der Vegt, MH; Vranken, JH; Wegener, JT, 2005) |
| "The purpose of this study is to compare the sedation recovery times of children receiving ketamine/midazolam (K/M) versus K/M and initial pain treatment (morphine or meperidine) in pediatric emergency care." | 3.73 | Effects of initial pain treatment on sedation recovery time in pediatric emergency care. ( Losek, JD; Reid, S, 2006) |
| " A 58-year-old man with multiple arthritis of rheumatic arthritis and fibromyalgia had headache, nausea, and vomiting all day after ketamine test." | 3.73 | [Postponed or canceled drug challenge tests and side effects of the test drug--a report of four cases]. ( Ann, Y; Arita, H; Asahara, M; Hanaoka, K; Kawamura, G; Mizuno, J; Sekiyama, H, 2006) |
| "IV Midazolam and IV Ketamine were used for PSA in pediatric oncology patients undergoing painful procedures." | 3.73 | Safe and efficacious use of procedural sedation and analgesia by non-anesthesiologists in a pediatric hematology-oncology unit. ( Advani, SH; Ambulkar, I; Borker, A; Gopal, R, 2006) |
| " These address opioids for the management of breakthrough (episodic) pain in cancer patients, perioperative ketamine for acute postoperative pain, and superficial heat or cold for low back pain." | 3.73 | Evidence-based pain management and palliative care in Issue One for 2006 of The Cochrane Library. ( Wiffen, PJ, 2006) |
| " The aim of the study was to assess the effect of non-competitive NMDA antagonists and paracetamol (propacetamol) on pain threshold and analgesic potency of this drugs and their combinations in formalin model for pain in rats." | 3.73 | [Dextromethorphan enhances analgesic activity of propacetamol--experimental study]. ( Dobrogowski, J; Przewłocka, B; Wordliczek, J, 2005) |
| "We have demonstrated the safe and effective use of ketamine analgesia in children with toxic megacolon, a condition in which the child is in severe pain and morphine is contraindicated." | 3.73 | Pain management in fulminating ulcerative colitis. ( Lindley, K; Lloyd-Thomas, A; Shah, N; Thomas, M; White, M, 2006) |
| "To determine the proportion of emergency departments in the UK that use modern pharmacological methods of pain and anxiety control in children, such as analgesia with intranasal diamorphine, procedural sedation using ketamine or midazolam, and adrenaline-cocaine gel, TAC or LAT for anaesthetising wounds in children." | 3.73 | Consigning "brutacaine" to history: a survey of pharmacological techniques to facilitate painful procedures in children in emergency departments in the UK. ( Chavada, G; Coats, T; Davies, F; Loryman, B, 2006) |
| " The present study examined the effects of combinations of dextromethorphan and ketamine, two clinically used N-methyl-D-aspartate (NMDA) receptor antagonists, with amitriptyline on formalin-evoked behaviors and paw edema." | 3.72 | Peripheral interactions between dextromethorphan, ketamine and amitriptyline on formalin-evoked behaviors and paw edema in rats. ( Reid, A; Sawynok, J, 2003) |
| " In the first series of experiments, RT and VPL responses to pinching with a small artery clamp were tested with the rats under pentobarbital, urethane, ketamine, or halothane anesthesia." | 3.72 | Reticular thalamic responses to nociceptive inputs in anesthetized rats. ( Shaw, FZ; Yen, CT, 2003) |
| "Topically administered capsaicin produces thermal allodynia, and this effect has been used to investigate pain transduction and its pharmacological modulation." | 3.72 | Topical capsaicin-induced allodynia in unanesthetized primates: pharmacological modulation. ( Ball, JW; Butelman, ER; Harris, TJ; Kreek, MJ, 2003) |
| "8% used inhalants (particularly isoflurane) for anesthesia, and ketamine, propofol, and butorphanol were the most commonly used injectable agents." | 3.72 | Evaluation of the use of anesthesia and analgesia in reptiles. ( Read, MR, 2004) |
| " We investigated here the effects of ketamine anesthesia on somatosensory processing in the rat spinal cord, thalamus, and cerebral cortex, using the quantitative 2-deoxyglucose mapping technique." | 3.72 | Effects of ketamine anesthesia on central nociceptive processing in the rat: a 2-deoxyglucose study. ( Baraldi, P; Cavazzuti, M; Giuliani, D; Lui, F; Porro, CA; Vellani, V, 2004) |
| "To determine whether intraarticular pretreatment with N-methyl-D-aspartic (NMDA) receptor antagonist ketamine or memantine currently used in humans has prophylactic analgesia in arthritic pain, we examined the effects of their intraarticular injection before carrageenan injection into the knee joint on pain-related behavior and spinal c-Fos expression in rats." | 3.72 | Intraarticular pretreatment with ketamine and memantine could prevent arthritic pain: relevance to the decrease of spinal c-fos expression in rats. ( Back, SK; Han, HC; Hong, SK; Kim, YI; Lee, KS; Min, SS; Na, HS; Yoon, SJ; Yoon, YW; Zhang, GH, 2004) |
| ") administration of 200mg/kg cyclophosphamide, an antitumoral agent, modified the behaviour of rats with cystitis induced by acrolein, a toxic urinary by-product of cyclophosphamide." | 3.71 | Involvement of N-methyl-D-aspartate receptors in nociception in the cyclophosphamide-induced vesical pain model in the conscious rat. ( Boucher, M; Coudoré-Civiale, MA; Eschalier, A; Méen, M; Parry, L, 2002) |
| "We describe an opioid-tolerant patient with severe acute pain which was unrelieved by morphine and ketamine via intravenous patient-controlled analgesia, but almost totally relieved by methadone." | 3.71 | Successful use of oral methadone after failure of intravenous morphine and ketamine. ( Mitchell, SJ; Sartain, JB, 2002) |
| "The present study examined the effects of local peripheral and systemic administration of three clinically used excitatory amino acid receptor antagonists (dextromethorphan, memantine, ketamine) on pain behaviors and edema produced by formalin (1." | 3.71 | Modulation of formalin-induced behaviors and edema by local and systemic administration of dextromethorphan, memantine and ketamine. ( Reid, A; Sawynok, J, 2002) |
| "Three patients with localized superficial pain had their pain alleviated by single epidural infusion with low dose ketamine." | 3.71 | [Usefulness of epidural infusion of ketamine for relief of localized superficial pain]. ( Ikeda, M; Kamakura, T; Machida, K; Mizuno, J; Sugimoto, S, 2001) |
| "Our report describes for the first time the continuous long-term intrathecal application of S(+)-ketamine in a patient with chronic pain and morphine tolerance." | 3.71 | The long-term antinociceptive effect of intrathecal S(+)-ketamine in a patient with established morphine tolerance. ( Deusch, E; Kress, HG; Maier, P; Sator-Katzenschlager, S; Spacek, A, 2001) |
| "In this study, we compared pain reduction produced by IV drugs (ketamine or alfentanil) with the ability to prevent injury-induced spinal cord changes." | 3.70 | Pre- versus postformalin effects of ketamine or large-dose alfentanil in the rat: discordance between pain behavior and spinal Fos-like immunoreactivity. ( Coderre, TJ; Gilron, I; Quirion, R, 1999) |
| "To evaluate accident and emergency (A&E) department led practice of ketamine sedation for painful, short procedures in the paediatric population and to ascertain parental response." | 3.70 | Accident and emergency department led implementation of ketamine sedation in paediatric practice and parental response. ( Gautam, V; Holloway, VJ; Husain, HM; Saetta, JP, 2000) |
| "We evaluated the safety and efficacy of midazolam-ketamine association to control pain induced by diagnostic procedures in paediatric oncology patients." | 3.70 | Use of intravenous ketamine-midazolam association for pain procedures in children with cancer. A prospective study. ( Granry, JC; Le Moine, P; Monrigal, JP; Pellier, I; Rialland, X; Rod, B, 1999) |
| "The aim of the present study was to observe the effect of repeated subcutaneous (sc) injections of low doses of ketamine for the treatment of acute inflammatory pain in a complete Freund's adjuvant-induced monoarthritic pain model in rats." | 3.70 | Repeated administration of low dose ketamine for the treatment of monoarthritic pain in the rat. ( Cao, Y; Han, JS; Huang, C; Wang, Y, 2000) |
| " This was reached in 74 cases with only one dose of ketamine, in 26 cases a second dose was needed, a same number needed nitrous oxide in addition and 9 times a second dose and nitrous oxide was given." | 3.69 | [Analgetic ketamine feasible in ambulance emergency care]. ( Ansem, RP; Foudraine, JF; Hartman, JA; Rutten, FL; van Loenen, E, 1994) |
| "To assess the benefit of ketamine addition to a morphine-clonidine-lidocaine mixture administered continuously by the intrathecal route for the treatment of cancer pain." | 3.69 | [Cancer pain: beneficial effect of ketamine addition to spinal administration of morphine-clonidine-lidocaine mixture]. ( Lemos, D; Muller, A, 1996) |
| "Ketamine has been used parenterally for pain unresponsive to opioids, including neuropathic pain, and has also been used as an alternative analgesic agent after surgery." | 3.69 | Ketamine injection used orally. ( Broadley, KE; Kurowska, A; Tookman, A, 1996) |
| "We report the effect of a single daily dose of ketamine in a 54 year old woman with fibromyalgia and severe post-traumatic neuropathic pain." | 3.69 | [Analgesic effect of ketamine in a patient with neuropathic pain]. ( Fagerlund, TH; Oye, I; Rabben, T, 1996) |
| "The therapeutic effects of dextrorphan and ketamine, two non-competitive N-methyl-D-aspartate (NMDA) receptor antagonists, on neuropathic pain-related behaviors were examined in rats with peripheral mononeuropathy induced by loose ligation of the common sciatic nerve (chronic constrictive injury, CCI)." | 3.68 | Intrathecal treatment with dextrorphan or ketamine potently reduces pain-related behaviors in a rat model of peripheral mononeuropathy. ( Frenk, H; Hayes, RL; Lu, J; Mao, J; Mayer, DJ; Price, DD, 1993) |
| "Our experience has shown ketamine to be a safe and effective method of providing pain relief during specific procedures in burned children." | 3.68 | Ketamine. A solution to procedural pain in burned children. ( Groeneveld, A; Inkson, T, 1992) |
| "Both chiral forms of ketamine caused analgesia when administered in subanesthetic doses to human volunteers suffering acute, experimentally induced ischemic pain." | 3.68 | Evidence of a role for NMDA receptors in pain perception. ( Klepstad, P; Maurset, A; Moberg, ER; Oye, I, 1990) |
| "The effect of ketamine infusion to control the intractable pain which had not responded to ordinary procedures in 12 patients with advanced cancer were evaluated." | 3.68 | [Ketamine infusion for control of pain in patients with advanced cancer]. ( Kanamaru, T; Katsumata, N; Mizuno, K; Ogawa, S; Saeki, S; Suzuki, H, 1990) |
| "Continuous intravenous infusions of ketamine and pentazocine have been used to provide analgesia in 18 patients with acute war injuries." | 3.67 | Infusion analgesia for acute war injuries. A comparison of pentazocine and ketamine. ( Bion, JF, 1984) |
| " doses of the full benzodiazepine inverse agonist beta-CCE immediately following cessation of exposure of rats to an anesthetic concentration of methoxyflurane significantly antagonized the duration of methoxyflurane anesthesia as measured by recovery of the righting reflex and/or pain sensitivity." | 3.67 | Antagonism of methoxyflurane-induced anesthesia in rats by benzodiazepine inverse agonists. ( Miller, DW; Tessel, RE; Yourick, DL, 1989) |
| "Hemorrhage is a leading cause of preventable battlefield and civilian trauma deaths." | 3.30 | Comparing the Effects of Low-Dose Ketamine, Fentanyl, and Morphine on Hemorrhagic Tolerance and Analgesia in Humans. ( Belval, LN; Cramer, MN; Crandall, CG; Foster, J; Hendrix, JM; Hinojosa-Laborde, C; Huang, M; Moralez, G; Watso, JC, 2023) |
| "Ketamine is an inexpensive drug with mechanisms of analgesia outside the opioid pathway including N-methyl-D-aspartate (NMDA) receptor antagonism and a pharmacologically unique property of opioid desensitisation." | 3.30 | Efficacy of ketamine mouthwash in the management of oral and pharyngeal toxicity associated with head and neck chemoradiotherapy: protocol for a phase II, Simon's two-stage trial. ( Eckstein, J; Frank, D; Ghaly, M; Herman, J; Koffler, D; Kohn, N; Martins-Welch, D; Parashar, B; Potters, L; Seetharamu, N; Sullivan, K, 2023) |
| " The efficacy and safety of the sedations including sedation time intervals, nausea score, vomiting episodes, pain score, adverse effects, and parent's satisfaction were evaluated." | 3.11 | The efficacy and safety of midazolam with fentanyl versus midazolam with ketamine for bedside invasive procedural sedation in pediatric oncology patients: A randomized, double-blinded, crossover trial. ( Lertvivatpong, N; Malaithong, W; Monsereenusorn, C; Photia, A; Rujkijyanont, P; Traivaree, C, 2022) |
| "The combination of ketamine-dexmedetomidine for procedural sedation during ERCP is a safe alternative to ketamine-propofol with a better respiratory profile." | 3.11 | Ketamine and dexmedetomidine (Keto-dex) or ketamine and propofol (Keto-fol) for procedural sedation during endoscopic retrograde cholangiopancreatography: Which is safer? A randomized clinical trial. ( Ahuja, V; Aravindan, A; Datta, PK; Ganesh, V; Iyer, KV; Khanna, P; Maitra, S; Sarkar, S; Singh, A, 2022) |
| "Ketamine has analgesic and antidepressant effects, but few studies have evaluated individual differences in antidepressant outcomes to repeated ketamine in TRD patients with comorbid pain." | 3.01 | Plasma inflammatory cytokines and treatment-resistant depression with comorbid pain: improvement by ketamine. ( Chao, Z; Lan, X; Li, H; Ning, Y; Wang, C; Zhou, Y, 2021) |
| "Using Department of Defense Trauma Registry data for the Afghanistan conflict from 2005 to 2018, we examined 2,402 records of prehospital analgesia administration to assess temporal trends in medication choice and proportions receiving analgesia, including subanalysis of a cohort screened for an indication with minimal contraindication for analgesia." | 3.01 | Patterns of Palliation: A Review of Casualties That Received Pain Management Before Reaching Role 2 in Afghanistan. ( Burgess, M; Hinojosa-Laborde, C; Hudson, IL; Newberry, RK; Ryan, KL; Schauer, SG; Staudt, AM; VanFosson, CA, 2023) |
| "Agitation commonly complicates polytrauma presentations, and is treated according to the danger it presents to patient and staff." | 3.01 | Management of Pain and Agitation in Trauma. ( Strayer, RJ, 2023) |
| " Secondary outcomes included postoperative visual analog scale (VAS) scores for pain and adverse effects associated with ketamine." | 3.01 | Efficacy and safety of perioperative application of ketamine on postoperative depression: A meta-analysis of randomized controlled studies. ( Gu, HW; Guo, J; Hashimoto, K; Qiu, D; Wang, XM; Yang, JJ; Zhang, GF, 2023) |
| "Propofol is a commonly used sedative, frequently combined with an opioid or low-dose ketamine as an analgesic." | 3.01 | Low-dose ketamine or opioids combined with propofol for procedural sedation in the emergency department: a systematic review. ( De Vries, LJ; Lameijer, H; Van Roon, EN; Veeger, NJGM, 2023) |
| "Ketamine has received considerable attention for its rapid and robust antidepressant response over the past decade." | 3.01 | Oral ketamine may offer a solution to the ketamine conundrum. ( Can, AT; Dutton, M; Hermens, DF; Lagopoulos, J, 2023) |
| " Our primary outcome was the proportion of patients experiencing any psychoperceptual side effect over 60 minutes." | 2.87 | Slow Infusion of Low-dose Ketamine Reduces Bothersome Side Effects Compared to Intravenous Push: A Double-blind, Double-dummy, Randomized Controlled Trial. ( Clattenburg, EJ; Flores, S; Hailozian, C; Haro, D; Herring, AA; Louie, D; Yoo, T, 2018) |
| "Postpartum depression is a common complication of childbirth." | 2.84 | Single bolus low-dose of ketamine does not prevent postpartum depression: a randomized, double-blind, placebo-controlled, prospective clinical trial. ( Chen, D; Huang, X; Li, Y; Ma, D; She, B; Xu, Y, 2017) |
| "Management of refractory pain in pediatric sickle cell disease (SCD) and oncology is reliant on opioids though high opioid dosing increases side effects and tachyphylaxis." | 2.82 | Low-dose Ketamine Infusion for Pediatric Hematology/Oncology Patients: Case Series and Literature Review. ( Agrawal, AK; Chen, A; Chen, E; Long, LS; Yu, H, 2022) |
| "Treatment with ketamine also documented a reduction in the values of the VAS/NRS for pain (random effects WMD: -8." | 2.82 | Pharmacological treatment in adult patients with CRPS-I: a systematic review and meta-analysis of randomized controlled trials. ( Adami, G; Benini, C; Fassio, A; Gatti, D; Gavioli, I; Mantovani, A; Rossini, M; Viapiana, O, 2022) |
| " Recommended changes to dosing strategies of medications such as ketamine." | 2.82 | Analgesia and Sedation for Tactical Combat Casualty Care: TCCC Proposed Change 21-02. ( April, MD; Blackman, V; Brown, J; Butler, FK; Cunningham, CW; DesRosiers, TT; Drew, B; Fisher, AD; Gurney, JM; Holcomb, JB; Montgomery, HR; Morgan, MM; Motov, SM; Papalski, W; Remley, MA; Schauer, SG; Shackelford, SA; Sprunger, T, 2022) |
| "IN ketamine was administered at enrolment, with a supplementary dose after 15 min, if required." | 2.78 | Sub-dissociative dose intranasal ketamine for limb injury pain in children in the emergency department: a pilot study. ( Graudins, A; Meek, R; Oakley, E; Yeaman, F, 2013) |
| "Propofol is a widely used anesthetic drug because of its minor complication and also its fast effect." | 2.77 | Comparison of effects of ephedrine, lidocaine and ketamine with placebo on injection pain, hypotension and bradycardia due to propofol injection: a randomized placebo controlled clinical trial. ( Ayatollahi, V; Behdad, S; Kargar, S; Yavari, T, 2012) |
| "Ketamine is a dissociative anesthetic agent with excellent analgesic properties and a favorable safety profile." | 2.72 | A review of the clinical applications of ketamine in pediatric oncology. ( Gupta, AK; Meena, JP; Prakash, S; Seth, R, 2021) |
| "Cold allodynia and hyperalgesia are frequent clinical findings in patients with neuropathic pain." | 2.71 | Cold allodynia and hyperalgesia in neuropathic pain: the effect of N-methyl-D-aspartate (NMDA) receptor antagonist ketamine--a double-blind, cross-over comparison with alfentanil and placebo. ( Jørum, E; Stubhaug, A; Warncke, T, 2003) |
| "Hyperalgesia has been documented during withdrawal and on occasion while animals were still exposed to opioids." | 2.71 | Short-term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal. ( Angst, MS; Clark, DJ; Koppert, W; Pahl, I; Schmelz, M, 2003) |
| " Intranasal ketamine was well tolerated with no serious adverse events." | 2.71 | Safety and efficacy of intranasal ketamine for the treatment of breakthrough pain in patients with chronic pain: a randomized, double-blind, placebo-controlled, crossover study. ( Albin, R; Brennen, L; Brookoff, D; Carr, DB; Denman, WT; Firestone, L; Goudas, LC; Green, G; Hamilton, D; Lavin, PT; Mermelstein, F; Rogers, MC; Staats, PS, 2004) |
| "The area of secondary hyperalgesia was quantitated using punctate (von Frey filaments) and brush stimuli (electric brush)." | 2.69 | Preinjury treatment with morphine or ketamine inhibits the development of experimentally induced secondary hyperalgesia in man. ( Jørum, E; Stubhaug, A; Warncke, T, 2000) |
| "Ketamine is a noncompetitive N-methyl-D-aspartate (NMDA) receptor channel blocker known to inhibit "wind-up" and hence central hyperexcitability of dorsal horn neurons." | 2.68 | The effect of N-methyl-D-aspartate antagonist (ketamine) on single and repeated nociceptive stimuli: a placebo-controlled experimental human study. ( Arendt-Nielsen, L; Bak, P; Bjerring, P; Fischer, M; Petersen-Felix, S; Zbinden, AM, 1995) |
| "Pain was evoked by non-noxious stimulation of the skin (allodynia) and by repeated pricking of the skin (wind-up-like pain)." | 2.68 | Central dysesthesia pain after traumatic spinal cord injury is dependent on N-methyl-D-aspartate receptor activation. ( Eide, PK; Stenehjem, AE; Stubhaug, A, 1995) |
| "The reduction in allodynia evoked by light stroking was statistically significant only for alfentanil." | 2.68 | Effects of intravenous ketamine, alfentanil, or placebo on pain, pinprick hyperalgesia, and allodynia produced by intradermal capsaicin in human subjects. ( Bennett, GJ; Gracely, RH; Max, MB; Park, KM; Robinovitz, E, 1995) |
| "Pain was assessed using visual analogue scales and sedation was graded on a four point rank drowsiness score." | 2.68 | Analgesia for acute musculoskeletal trauma: low-dose subcutaneous infusion of ketamine. ( Bhattacharya, A; Gurnani, A; Rautela, RS; Sharma, PK, 1996) |
| "Pain was analyzed in patients with fibromyalgia (FM) in a randomized, double blind, crossover study using intravenous (i." | 2.68 | Fibromyalgia--are there different mechanisms in the processing of pain? A double blind crossover comparison of analgesic drugs. ( Ahlner, J; Bengtsson, A; Bengtsson, M; Ekselius, L; Henriksson, KG; Sörensen, J, 1997) |
| "Ischemic pain was induced by the submaximum effort tourniquet technique." | 2.67 | The influence of adenosine, ketamine, and morphine on experimentally induced ischemic pain in healthy volunteers. ( Ekblom, A; Segerdahl, M; Sollevi, A, 1994) |
| "Ketamine is an NMDA-blocking agent widely used in human medicine." | 2.67 | Response of chronic neuropathic pain syndromes to ketamine: a preliminary study. ( Arndt, G; Backonja, M; Check, B; Gombar, KA; Zimmermann, M, 1994) |
| "Twenty traumatized patients suffering from fractures and soft tissue injury were given either 0." | 2.66 | [Intravenous analgesia with ketamine for emergency patients]. ( Hirlinger, WK; Pfenninger, E, 1987) |
| "Ketamine has unique pharmacologic properties that may prevent the development of pain as well as reduce chronic pain." | 2.58 | Emerging Trends in Pain Medication Management: Back to the Future: A Focus on Ketamine. ( Atkinson, TJ; Bryant, C; Crumb, MW, 2018) |
| " A literature review was performed to ascertain potential side effects and/or adverse events when using ketamine for analgesia purposes." | 2.55 | Ketamine for Pain Management-Side Effects & Potential Adverse Events. ( Allen, CA; Ivester, JR, 2017) |
| "Mechanistic approaches and multimodal analgesic techniques have been clearly demonstrated to be the most effective pain management strategy to improve outcomes." | 2.55 | Analgesia in the surgical intensive care unit. ( Brudney, CS; Ehieli, E; Pyati, S; Yalamuri, S, 2017) |
| "Ketamine is a fast acting N-methyl-d-aspartate (NMDA) receptor antagonist that provides safe and effective analgesia." | 2.55 | Low dose ketamine use in the emergency department, a new direction in pain management. ( Alhawas, R; Mazer-Amirshahi, M; Pourmand, A; Royall, C; Shesser, R, 2017) |
| "Ketamine is a phencyclidine derivative, which functions primarily as an antagonist of the N-methyl-D-aspartate receptor." | 2.53 | Ketamine: A Review of Clinical Pharmacokinetics and Pharmacodynamics in Anesthesia and Pain Therapy. ( Hagelberg, NM; Olkkola, KT; Peltoniemi, MA; Saari, TI, 2016) |
| " Apart from being valuable in drug development programs, the outlined approach can be used to determine the choice of drug and dose in the treatment of pain in patients with potent and toxic analgesics." | 2.52 | Pharmacotherapy for pain: efficacy and safety issues examined by subgroup analyses. ( Dahan, A; Niesters, M; Olofsen, E, 2015) |
| "Propofol is an agent commonly used for procedural sedation and analgesia (PSA) in the emergency department (ED), but it can cause respiratory depression and hypotension." | 2.52 | Ketamine-Propofol Versus Propofol Alone for Procedural Sedation in the Emergency Department: A Systematic Review and Meta-analysis. ( Iansavitchene, A; McLeod, SL; Yan, JW, 2015) |
| " After long-term use as a dissociative anesthetic, it has re-emerged as a useful agent for ameliorating pain, asthmaticus, and depression." | 2.50 | Ketamine-an update on its clinical uses and abuses. ( Lei, H; Xu, J, 2014) |
| "Intubation of the trachea and mechanical ventilation are ubiquitous painful procedures in the neonatal intensive care unit that are poorly assessed and treated." | 2.49 | Sedation and analgesia to facilitate mechanical ventilation. ( Colby, CE; Nemergut, ME; Yaster, M, 2013) |
| "Studies on oral ketamine for cancer and neuropathic pain have shown mixed results which could be partially due to significant differences in hepatic metabolism." | 2.48 | Oral ketamine in the palliative care setting: a review of the literature and case report of a patient with neurofibromatosis type 1 and glomus tumor-associated complex regional pain syndrome. ( Baker, K; Berger, AM; Handel, D; Mannes, AJ; Ruppert, SL; Soto, E; Stewart, DR; Zlott, D, 2012) |
| "Ketamine is a lipophilic, general anesthetic." | 2.48 | Ketamine for pain: an update of uses in palliative care. ( Prommer, EE, 2012) |
| " It also reviews the comparative pharmacokinetics, adverse effects, and dosing of ketamine, propofol, and ketofol as agents for procedural sedation and analgesia." | 2.48 | Ketamine, propofol, and ketofol use for pediatric sedation. ( Alletag, MJ; Auerbach, MA; Baum, CR, 2012) |
| "In spite of improvements in wound treatment and pain regimens during recent years, the management of burn pain still remains a common problem and a tremendous challenge for clinical staff." | 2.47 | [Pain management of burn injuries]. ( Girtler, R; Gustorff, B, 2011) |
| "Ketamine has become increasingly recognized as a drug of recreational use." | 2.47 | Recreational ketamine: from pleasure to pain. ( Baker, SC; Cottrell, A; Fulford, S; Gillatt, D; Harris, M; Southgate, J; Wood, D; Woodhouse, C, 2011) |
| "Ketamine is an N-methyl-D-aspartate receptor antagonist that has been in clinical use in the USA for over 30 years." | 2.47 | Ketamine in pain management. ( Cohen, SP; Gupta, A; Liao, W; Plunkett, A, 2011) |
| "Ketamine is a safe and effective analgesic agent." | 2.47 | Ketamine as an analgesic in the pre-hospital setting: a systematic review. ( Bernard, S; Cameron, P; Jennings, PA, 2011) |
| " There was no consistent dose-response relation." | 2.46 | Use of oral ketamine in chronic pain management: a review. ( Blonk, MI; Huygen, FJ; Koder, BG; van den Bemt, PM, 2010) |
| "Ketamine has been shown to produce antihyperalgesic effects produced by incision and tissue or nerve damage, and has become popular in equine practice as an anesthetic and more recently as an analgesic for standing surgical procedures and the treatment of laminitis." | 2.46 | NMDA receptor antagonists and pain: ketamine. ( Muir, WW, 2010) |
| "neuropathic pain) is not very satisfactorily managed." | 2.44 | [Central and peripheral mechanisms in antinociception: current and future perspectives]. ( Fürst, Z, 2008) |
| "Ketamine is a dissociative anaesthetic that has been used in the clinic for many years." | 2.44 | Low dose ketamine: a therapeutic and research tool to explore N-methyl-D-aspartate (NMDA) receptor-mediated plasticity in pain pathways. ( Chizh, BA, 2007) |
| "Pain is an unpleasant sensation that originates from ongoing or impending tissue damage." | 2.44 | Recent advances in the pharmacological management of pain. ( Beaulieu, P; Guindon, J; Walczak, JS, 2007) |
| "Pain is a multidimensional symptom that can overshadow all other experiences of both the child and family." | 2.44 | The management of pain in children with life-limiting illnesses. ( Friedrichsdorf, SJ; Kang, TI, 2007) |
| " Nursing considerations include close monitoring of vital signs during the initial dosage and follow-up observations of the effectiveness of the medications." | 2.44 | The use of ketamine as adjuvant therapy to control severe pain. ( Campbell-Fleming, JM; Williams, A, 2008) |
| "Ketamine is a dissociative anaesthetic; its mechanism of action is primarily an antagonism of the N-methyl-D-aspartate (NMDA) receptor." | 2.43 | The role of ketamine in pain management. ( Schug, SA; Visser, E, 2006) |
| "Intense pain and cutaneous hyperesthesia are prominent features." | 2.43 | Symptomatic management of calciphylaxis: a case series and review of the literature. ( Ashby, MA; Bryan, T; Martin, P; Polizzotto, MN, 2006) |
| "Dextromethorphan and ketamine were found to have significant immediate and preventive analgesic benefit in 67% and 58% of studies, respectively." | 2.42 | A qualitative systematic review of the role of N-methyl-D-aspartate receptor antagonists in preventive analgesia. ( Katz, J; McCartney, CJ; Sinha, A, 2004) |
| "Pain is the primary problem targeted for control using the World Health Organization's (WHO) analgesic ladder." | 2.41 | Advances in cancer pain management. ( Hamann, SR; McDonnell, FJ; Sloan, JW, 2000) |
| "Tramadol is a centrally acting analgesic drug; it has an agonist effect on mu 1 receptors of opioids and acts also by inhibiting the re-uptake of noradrenaline and serotonine which activates descending monoaminergic inhibitory pathways." | 2.40 | [Treatment of pain in oncology]. ( De Conno, F; Polastri, D, 1997) |
| "Pain is an important indicator of stress particularly after surgical operation." | 2.39 | Clinical applications of excitatory amino acid antagonists in pain management. ( Cherng, CH; Ho, ST; Wong, CS, 1995) |
| "Ketamine has been shown to have potent analgesic properties at low dosages." | 2.39 | Ketamine in cancer pain: an update. ( Mercadante, S, 1996) |
| " Demographic and clinical data, including age, length of the procedure, recovery time, medication doses, and adverse events, were collected." | 1.91 | Safety and Efficacy of Propofol- and Ketamine-Based Procedural Sedation Regimen in Pediatric Patients During Burn Repetitive Dressing Change: 10 Years Single Center Experience. ( Abu-Sultaneh, S; Abulebda, K; Lutfi, R; Shieh Yu, J; Slaven, JE; Yabrodi, M, 2023) |
| " This study aimed to evaluate differences in pain management and adverse effects of ketamine and opioid administration." | 1.91 | Treating Prehospital Pain in Children: A Retrospective Chart Review Comparing the Safety and Efficacy of Prehospital Pediatric Ketamine and Opioid Analgesia. ( Brent, C; Cranford, JA; Hunt, N; Mahmood, A; Masiewicz, S; Noel, S; Wagner, D, 2023) |
| "Ketamine was started a median of 13." | 1.91 | Ketamine use for management of vaso-occlusive pain in pediatric sickle cell disease. ( Archer, NM; Donado, C; Greco, C; Harris, EM; Heeney, MM; Solodiuk, J; Vilk, E; Williams, A, 2023) |
| "Ketamine has been used in the emergency department (ED) as an anesthetic agent for procedural sedation, and when administrated in a sub-dissociative dose (low dose) at 0." | 1.72 | Paraphimosis Pain Treatment with Nebulized Ketamine in the Emergency Department. ( Barberan Parraga, C; Cen, E; Davis, A; Dove, D; Drapkin, J; Fassassi, C; Hossain, R; Mahl, E; Motov, S; Peng, Y, 2022) |
| "Erythromelalgia is a rare neurovascular pain condition characterized by erythematous, warm, and painful extremities." | 1.72 | Intravenous Ketamine Infusion as an Adjunctive Pain Treatment for Erythromelalgia: A Pediatric Case Report. ( Adams, AC; Montoya, L; Popenhagen, MP; Price, HN; Russi, DC; Singhal, NR, 2022) |
| "Ketamine was identified as safe and effective for battlefield use, and further research into nonopioid analgesics represented a high priority." | 1.72 | Battlefield pain summit 2022: Expert consensus statements. ( Cannon, JW; Cap, AP; Davidson, NL; Polk, TM; Shackelford, SA; Stallings, JD; Stark, TR, 2022) |
| "Ketamine was administered to mice acute and chronically with/without nitric oxide synthase (NOS) inhibitors." | 1.72 | The N-methyl-D-aspartate receptor antagonist ketamin exerts analgesic effects via modulation of the nitric oxide pathway. ( Dehpour, AR; Goudarzi, S; Mahmoudzade, S; Mohammad Jafari, R; Sanatkar, M; Shafaroodi, H, 2022) |
| "Pediatric lacerations are frequently encountered by plastic surgeons in the emergency room." | 1.72 | Effect of sedation using Ketamine for primary closure of pediatric facial laceration. ( Kim, HJ; Kim, JH; Kim, SH; Lee, JH; Shin, SH; Suh, IS; Woo, SS, 2022) |
| " Kinetic analyses of MLK infusions in cattle are necessary to establish optimal dosing protocols and withdrawal intervals." | 1.56 | Analgesic efficacy of an intravenous constant rate infusion of a morphine-lidocaine-ketamine combination in Holstein calves undergoing umbilical herniorrhaphy. ( Coetzee, JF; Hartnack, AK; Kleinhenz, MD; Lakritz, J; Niehaus, AJ, 2020) |
| "Drugs used to treat pain are associated with adverse effects, increasing the search for new drugs as an alternative treatment for pain." | 1.56 | Antinociceptive activity of 3β-6β-16β-trihydroxylup-20 (29)-ene triterpene isolated from Combretum leprosum leaves in adult zebrafish (Danio rerio). ( Bandeira, PN; Campos, AR; da Silva, AW; de Menezes, JESA; Dos Reis Lima, J; Dos Santos, HS; Evaristo, FFV; Ferreira, MKA; Holanda, CLA; Magalhães, FEA; Silva, FCO; Teixeira, EH, 2020) |
| "Ketamine infusions have been reported to help alleviate acute exacerbations or "flare-ups" of CRPS symptoms." | 1.56 | Anesthetic Management of a Complex Regional Pain Syndrome (CRPS) Patient With Ketamine. ( Mundluru, T; Saraghi, M, 2020) |
| "capsaicin-induced thermal allodynia) are unknown." | 1.48 | Additive and subadditive antiallodynic interactions between μ-opioid agonists and N-methyl D-aspartate antagonists in male rhesus monkeys. ( Banks, ML; Cornelissen, JC; Nicholson, KL; Rice, KC; Steele, FF, 2018) |
| "Ketamine has been widely used as an analgesic and produces dissociative anesthetic effects." | 1.48 | The Involvement of the Endocannabinoid System in the Peripheral Antinociceptive Action of Ketamine. ( Castor, MGM; Di Marzo, V; Duarte, IDG; Ferreira, RCM; Piscitelli, F; Romero, TRL, 2018) |
| "Ketamine is an effective drug for battlefield analgesia." | 1.48 | Ketamine for military prehospital analgesia and sedation in combat casualties. ( Moy, R; Wright, C, 2018) |
| " Outcomes studied included impact on opioid analgesic use, a description of ketamine dosing strategy, and an analysis of adverse events due to opioid or ketamine analgesia." | 1.48 | Low-Dose Ketamine Infusion for Adjunct Management during Vaso-occlusive Episodes in Adults with Sickle Cell Disease: A Case Series. ( Boylan, A; Floroff, C; Hassig, TB; Kanter, J; Palm, N, 2018) |
| "The administration of ketamine during burn wound care using a critical care RN-driven protocol was associated with reduced opioid and benzodiazepine requirements and few adverse effects." | 1.48 | CE: Original Research: The Efficacy and Safety of an RN-Driven Ketamine Protocol for Adjunctive Analgesia During Burn Wound Care. ( Baumgartner, L; MacLaren, R; Townsend, N; Winkelman, K, 2018) |
| "Patients with advanced cancer often suffer from both severe pain and severe symptoms of depression." | 1.48 | Case Report: Ketamine for Pain and Depression in Advanced Cancer. ( Atayee, RS; Bruner, HC; Sexton, J, 2018) |
| "Current therapeutic approaches to depression fail for millions of patients due to lag in clinical response and non-adherence." | 1.46 | Population scale data reveals the antidepressant effects of ketamine and other therapeutics approved for non-psychiatric indications. ( Abagyan, R; Atayee, R; Cohen, IV; Makunts, T, 2017) |
| " This adverse effect has not been reported previously at this dosing range." | 1.46 | A Case Report: Subanesthetic Ketamine Infusion for Treatment of Cancer-Related Pain Produces Urinary Urge Incontinence. ( Hunsberger, J; Lee, W; Vickers, BA, 2017) |
| "Meperidine was applied to animals with increasing doses and their tail flick latencies (TFL) were noted at 20, 40, 60, 90, 120, 180, and 240 min." | 1.43 | Combination of paracetamol or ketamine with meperidine enhances antinociception. ( Akkar, OB; Cetin, A; Cetin, M; Gulturk, S; Kula, A, 2016) |
| " In the acute toxicity test, the LD50 estimated for CPE was>5000 mg/kg p." | 1.43 | Pharmacological effects and toxicity of Costus pulverulentus C. Presl (Costaceae). ( Alonso-Castro, AJ; Carranza-Álvarez, C; González-Chávez, MM; Hernández-Benavides, DM; Hernández-Morales, A; Zapata-Morales, JR, 2016) |
| "Fentanyl was preferred for paediatric patients and ketamine was preferentially administered for severe pain by physicians who had more medical experience or had trained in anaesthesia." | 1.43 | A two-year retrospective review of the determinants of pre-hospital analgesia administration by alpine helicopter emergency medical physicians to patients with isolated limb injury. ( Albrecht, E; Eidenbenz, D; Hugli, O; Pasquier, M; Taffé, P, 2016) |
| "Pain is a significant side effect of disease, surgery and treatments including chemotherapy." | 1.43 | Pain management for chemotherapy-induced oral mucositis. ( Bennett, M, 2016) |
| "Intractable cancer-related pain complicated by a neuropathic component due to nerve impingement is poorly alleviated even by escalating doses of a strong opioid analgesic." | 1.42 | Novel polymeric bioerodable microparticles for prolonged-release intrathecal delivery of analgesic agents for relief of intractable cancer-related pain. ( Han, FY; Lam, AL; Smith, MT; Thurecht, KJ; Whittaker, AK, 2015) |
| "IN ketamine dose was 0." | 1.40 | Sub-dissociative-dose intranasal ketamine for moderate to severe pain in adult emergency department patients. ( Egerton-Warburton, D; Graudins, A; Meek, R; Rosengarten, P; Yeaman, F, 2014) |
| "Ketamine was administered into the right hind paw 2 hours and 55 minutes after local injection of PGE2 ." | 1.39 | Involvement of ATP-sensitive K(+) channels in the peripheral antinociceptive effect induced by ketamine. ( Duarte, ID; Romero, TR, 2013) |
| "Pain is a problem that often has to be addressed in the prehospital setting." | 1.39 | Prehospital analgesia using nasal administration of S-ketamine--a case series. ( Johansson, J; Nordgren, M; Sandström, E; Sjöberg, F; Sjöberg, J; Zetterström, H, 2013) |
| "The ketamine usage pattern was recorded: initiation, administration route, dose in the last month and frequency of usage." | 1.38 | [Cystitis and ketamine associated bladder dysfunction]. ( Arango, O; Bielsa, O; Castillo, C; García-Larrosa, A; Lorente, JA; Ventura, M, 2012) |
| "Ketamine was administered epidurally at doses of 1 and 2 mg kg(-1) (five animals in each treatment)." | 1.38 | Epidural ketamine in the dromedary camel. ( Azari, O; Emadi, L; Esmaeili, M; Molaei, MM; Sakhaee, E, 2012) |
| "Pain was also improved, although for a shorter duration." | 1.38 | Mood and pain responses to repeat dose intramuscular ketamine in a depressed patient with advanced cancer. ( Glue, P; Perez, D; Zanicotti, CG, 2012) |
| "heat allodynia) followed by a persistent area of secondary tactile allodynia." | 1.36 | Human experimental pain models 3: heat/capsaicin sensitization and intradermal capsaicin models. ( Modir, JG; Wallace, MS, 2010) |
| " With intravenous administration the onset of action is within 1 min and the effects last for about 5 to 10 min, depending on dosage level and individual variation." | 1.36 | Taming the ketamine tiger. 1965. ( Domino, EF, 2010) |
| "It had less effect on tactile allodynia (CCI)." | 1.35 | Effects of norketamine enantiomers in rodent models of persistent pain. ( Crooks, PA; Hojomat, M; Holtman, JR; Johnson-Hardy, JK; Kleven, M; Wala, EP, 2008) |
| "Oral ketamine has been found to be effective during invasive procedures in children with malignancy." | 1.35 | Oral ketamine for pain relief in a child with abdominal malignancy. ( Boyaci, A; Gulcu, N; Ugur, F, 2009) |
| "Premature infants experience untreated repetitive pain that may alter their brain development." | 1.34 | Ketamine reduces the cell death following inflammatory pain in newborn rat brain. ( Anand, KJ; Bhutta, AT; Garg, S; Hall, RW; Narsinghani, U; Rovnaghi, CR, 2007) |
| "Ketamine is an ideal drug for use in many prehospital situations." | 1.34 | Ketamine for prehospital use: new look at an old drug. ( Abernathy, MK; Svenson, JE, 2007) |
| "Pretreatment with resiniferatoxin, an ultrapotent analogue of capsaicin, halved during-discharges and eliminated after-discharges, suggesting that after-discharges are generated by heat- and mechanosensitive polymodal nociceptors." | 1.33 | Spinal ventral root after-discharges as a pain index: involvement of NK-1 and NMDA receptors. ( Honda, M; Ono, H; Tanabe, M; Yamamoto, S, 2006) |
| "Opiates may be used to attenuate chronic pain, but long-term use is complicated by the possible increase in pain over time, escalating dose requirements, and untoward side effects." | 1.33 | Enhancement of morphine antinociception with the peptide N-methyl-D-aspartate receptor antagonist [Ser1]-histogranin in the rat formalin test. ( Basler, A; Hama, A; Sagen, J, 2006) |
| "Muscle pain is a major clinical problem but the underlying mechanisms and its pharmacological modulation need further investigation." | 1.32 | Pharmacological modulation of experimental phasic and tonic muscle pain by morphine, alfentanil and ketamine in healthy volunteers. ( Arendt-Nielsen, L; Graven-Nielsen, T; Jansson, Y; Schulte, H; Segerdahl, M; Sollevi, A, 2003) |
| "When ketamine was used as the general anesthetic, self-mutilation was almost suppressed (13%) and consisted of superficial erosions." | 1.32 | Effects of anesthesia and nociceptive stimulation in an experimental model of brachial plexus avulsion. ( Rokyta, R; Vaculín, S, 2004) |
| "Dextromethorphan produced lower ED(50) values for morphine, fentanyl and sufentanil but exerted no effect on the potency of SNC80 or U50,488H." | 1.31 | Dextromethorphan and ketamine potentiate the antinociceptive effects of mu- but not delta- or kappa-opioid agonists in a mouse model of acute pain. ( Baker, AK; Hoffmann, VL; Meert, TF, 2002) |
| "The initial hyperalgesia induced by 0." | 1.31 | Large-amplitude 5-HT1A receptor activation: a new mechanism of profound, central analgesia. ( Assié, MB; Bardin, L; Carilla-Durand, E; Colpaert, FC; Cosi, C; Koek, W; Pauwels, PJ; Tarayre, JP; Vacher, B; Wiesenfeld-Hallin, Z; Xu, XJ, 2002) |
| "Clonidine was also evaluated in combination with ketamine and dextromethorphan." | 1.31 | Interactions of NMDA antagonists and an alpha 2 agonist with mu, delta and kappa opioids in an acute nociception assay. ( Baker, AK; Hoffmann, VL; Meert, TF, 2002) |
| "Neuropathic pain has been shown to respond to drugs that block the N-methyl-D-aspartate (NMDA) receptor, such as ketamine and amantidine." | 1.31 | An unusual case of chronic neuropathic pain responds to an optimum frequency of intravenous ketamine infusions. ( Mitchell, AC, 2001) |
| "Ketamine is a non-competitive N-methyl D-aspartate (NMDA) receptor antagonist with analgesic and dissociative anesthetic properties." | 1.31 | Low dose ketamine as an analgesic adjuvant in difficult pain syndromes: a strategy for conversion from parenteral to oral ketamine. ( Fitzgibbon, EJ; Hall, P; Schroder, C; Seely, J; Viola, R, 2002) |
| "Ketamine has been found to exert antinociceptive effects in animals and to be analgesic at subanaesthetic doses in humans." | 1.31 | Potentiation by ketamine of fentanyl antinociception. I. An experimental study in rats showing that ketamine administered by non-spinal routes targets spinal cord antinociceptive systems. ( Bajunaki, E; Goodchild, CS; Nadeson, R; Tucker, A, 2002) |
| "The onset of resultant hyperalgesia was evaluated using von Frey monofilaments." | 1.30 | Preemptive intrathecal ketamine delays mechanical hyperalgesia in the neuropathic rat. ( Hartrick, CT; Patterson, JS; Wise, JJ, 1998) |
| "His pain was diagnosed as neuropathic pain (complex regional pain syndrome, type II)." | 1.30 | The NMDA-receptor antagonist ketamine abolishes neuropathic pain after epidural administration in a clinical case. ( Miyazaki, M; Morita, S; Nanbu, T; Takahashi, H; Yanagida, H, 1998) |
| "Ketamine has been found to be a useful agent for analgesia in burn-wound patients; a dose of 10 mg/kg qid per os was found to be an effective adjunct to pain therapy." | 1.30 | Ketamine hydrochloride--an adjunct for analgesia in dogs with burn wounds. ( Joubert, K, 1998) |
| "The present study was designed to evaluate the oral efficacy and bioavailability of ketamine." | 1.30 | Oral ketamine is antinociceptive in the rat formalin test: role of the metabolite, norketamine. ( Elliott, KJ; Gorman, AL; Inturrisi, CE; Shimoyama, M; Shimoyama, N, 1999) |
| "Ketamine was not observed to produce any change in either RF size or neuronal response to non-noxious RF stimulation." | 1.29 | Effect of propofol on spinal dorsal horn neurons. Comparison with lack of ketamine effects. ( Collins, JG; Kishikawa, K; Uchida, H, 1995) |
| "(S)-Ketamine was at least 4 times as potent as (R)-ketamine in this respect." | 1.28 | Effects of ketamine on sensory perception: evidence for a role of N-methyl-D-aspartate receptors. ( Maurset, A; Oye, I; Paulsen, O, 1992) |
| "Ketamine was injected peritoneally in dosage of 4 mg/kg and 20 mg/kg respectively." | 1.28 | [Effect of ketamine on acupuncture analgesia]. ( Chen, ZQ; Xu, W; Yan, YS, 1989) |
| "Newer approaches to assessing and managing pain in these patients must be explored." | 1.27 | Pain control during the intensive care phase of burn care. ( Heimbach, DM; Marvin, JA, 1985) |
| "If emergency physicians would treat the pain of their patients as they would want it to be treated in themselves or their families, then we will have made great strides as a specialty in mastering the art and science of analgesia." | 1.27 | Pain management in the child. ( Paris, PM, 1987) |
| " Plasma ketamine concentration-time curves were fitted by a two-compartment open model with a terminal half-life of 186 min." | 1.26 | Bioavailability, pharmacokinetics, and analgesic activity of ketamine in humans. ( Clements, JA; Grant, IS; Nimmo, WS, 1982) |
| "Pain was produced by brief electric stimuli on the wrist." | 1.25 | Hypno-analgesia and acupuncture analgesia: a neurophysiological reality? ( Brown, M; Saletu, B; Saletu, M; Sletten, I; Stern, J; Ulett, G, 1975) |
Research
Studies (598)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 24 (4.01) | 18.7374 |
| 1990's | 82 (13.71) | 18.2507 |
| 2000's | 199 (33.28) | 29.6817 |
| 2010's | 193 (32.27) | 24.3611 |
| 2020's | 100 (16.72) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Yu, H | 1 |
| Chen, A | 1 |
| Chen, E | 2 |
| Long, LS | 1 |
| Agrawal, AK | 2 |
| Heydari, F | 1 |
| Zhou, Y | 2 |
| Wang, C | 2 |
| Lan, X | 2 |
| Li, H | 1 |
| Chao, Z | 1 |
| Ning, Y | 2 |
| Madathil, S | 1 |
| Thomas, D | 1 |
| Chandra, P | 1 |
| Agarwal, R | 1 |
| Sankar, MJ | 1 |
| Thukral, A | 1 |
| Deorari, A | 1 |
| Aminnejad, R | 1 |
| Hormati, A | 1 |
| Shafiee, H | 1 |
| Alemi, F | 1 |
| Hormati, M | 1 |
| Saeidi, M | 1 |
| Ahmadpour, S | 1 |
| Sabouri, SM | 1 |
| Aghaali, M | 1 |
| Qiu, J | 1 |
| Xie, M | 1 |
| Aghaei, V | 1 |
| Hino, C | 1 |
| Ran-Castillo, D | 1 |
| Akhtari, M | 1 |
| Cao, H | 1 |
| Silvestre, J | 1 |
| Barberan Parraga, C | 1 |
| Peng, Y | 1 |
| Cen, E | 1 |
| Dove, D | 1 |
| Fassassi, C | 1 |
| Davis, A | 1 |
| Drapkin, J | 3 |
| Hossain, R | 1 |
| Mahl, E | 1 |
| Motov, S | 3 |
| Fassio, A | 1 |
| Mantovani, A | 1 |
| Gatti, D | 1 |
| Rossini, M | 1 |
| Viapiana, O | 1 |
| Gavioli, I | 1 |
| Benini, C | 1 |
| Adami, G | 1 |
| Singh, V | 1 |
| Gillespie, TW | 1 |
| Lane, O | 1 |
| Spektor, B | 1 |
| Zarrabi, AJ | 1 |
| Egan, K | 1 |
| Curseen, K | 1 |
| Tsvetkova, M | 1 |
| Beumer, JH | 1 |
| Sniecinski, R | 1 |
| Shteamer, JW | 1 |
| Switchenko, J | 1 |
| Harvey, RD | 1 |
| Olofsen, E | 5 |
| Kamp, J | 1 |
| Henthorn, TK | 1 |
| van Velzen, M | 1 |
| Niesters, M | 9 |
| Sarton, E | 6 |
| Dahan, A | 11 |
| van Bockxmeer, JJ | 1 |
| Lau, A | 1 |
| Varshney, V | 1 |
| Mashour, GA | 1 |
| Hayashi, M | 1 |
| Shimamura, Y | 1 |
| Shiroshita, A | 1 |
| Cooper-Sood, JB | 1 |
| Hagar, W | 1 |
| Marsh, A | 1 |
| Hoppe, C | 1 |
| Montoya, L | 1 |
| Adams, AC | 1 |
| Popenhagen, MP | 1 |
| Russi, DC | 1 |
| Singhal, NR | 1 |
| Price, HN | 1 |
| Ballard, ED | 1 |
| Farmer, CA | 1 |
| Gerner, J | 1 |
| Bloomfield-Clagett, B | 1 |
| Park, LT | 1 |
| Zarate, CA | 1 |
| Li, X | 1 |
| Xiang, P | 1 |
| Liang, J | 1 |
| Deng, Y | 1 |
| Du, J | 1 |
| Grégoire, C | 1 |
| De Kock, M | 2 |
| Henrie, J | 1 |
| Cren, R | 1 |
| Lavand'homme, P | 3 |
| Penaloza, A | 1 |
| Verschuren, F | 1 |
| Cohen, B | 2 |
| Talmy, T | 1 |
| Gelikas, S | 1 |
| Radomislensky, I | 1 |
| Kontorovich-Chen, D | 1 |
| Benov, A | 1 |
| Avital, G | 1 |
| Fisher, AD | 1 |
| DesRosiers, TT | 1 |
| Papalski, W | 1 |
| Remley, MA | 1 |
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Clinical Trials (95)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Ketamine Versus Fentanyl for Surgical Abortions: A Randomized Controlled Noninferiority Trial[NCT04871425] | Phase 4 | 110 participants (Actual) | Interventional | 2021-04-27 | Completed | ||
| Ultrasound Guided Versus Fluoroscopy Guided Lumber Sympathetic Block in Chronic Lower Limb Ischemia[NCT06073795] | 60 participants (Anticipated) | Observational | 2023-11-01 | Not yet recruiting | |||
| Paravertebral Block Versus Simultaneous Ketamine and Lidocaine Infusions for Pain Management in Rib Fracture Patients[NCT04413799] | Early Phase 1 | 170 participants (Anticipated) | Interventional | 2020-09-01 | Recruiting | ||
| Impact of Night-time Dexmedetomidine-esketamine Infusion on Sleep Quality of Patients With Mechanical Ventilation in ICU: a Randomized Controlled Trial[NCT05718024] | Phase 4 | 174 participants (Anticipated) | Interventional | 2023-12-31 | Not yet recruiting | ||
| Dexmedetomidine-esketamine Combined With Oxycodone for Ultrasound-guided Percutaneous Radiofrequency Ablation in Patients With Liver Cancer: a Randomized Controlled Study[NCT06003218] | 88 participants (Anticipated) | Interventional | 2023-10-16 | Recruiting | |||
| Effects of Low-dose Dexmedetomidine-esketamine Combined Nasal Administration at Night on Perioperative Sleep Quality in Breast Cancer Patients: a Randomized, Double-blind, Placebo-controlled Trial[NCT05732064] | Phase 4 | 180 participants (Anticipated) | Interventional | 2023-05-22 | Recruiting | ||
| Pilot Study: Ketamine for Acute Pain After Rattlesnake Envenomation[NCT05379179] | Phase 4 | 40 participants (Anticipated) | Interventional | 2022-06-20 | Enrolling by invitation | ||
| Effects of Low-dose S-ketamine on the Incidence of Postpartum Depression in Women With Prenatal Depression: a Randomized, Double-blind, Placebo-controlled Trial[NCT04414943] | 364 participants (Actual) | Interventional | 2020-06-19 | Completed | |||
| Comparison of Sub-dissociative Intranasal Ketamine Plus Standard Pain Therapy Versus Standard Pain Therapy in the Treatment of Pediatric Sickle Cell Disease Vasoocclusive Crises in Resource-limited Settings: a Multi-centered, Randomized, Controlled Trial[NCT02573714] | 160 participants (Anticipated) | Interventional | 2015-12-31 | Recruiting | |||
| A pRospective, Case-controlled Evaluation of oLIceridine for Moderate or sEVEre Pain in Patients With Acute Burn Injuries. (RELIEVE)[NCT05465226] | Phase 4 | 31 participants (Actual) | Interventional | 2023-04-01 | Completed | ||
| Intravenous Sub-dissociative Dose Ketamine Injection Versus Infusion for Analgesia in the Emergency Department: A Prospective, Randomized, Double-blind Placebo Controlled Trial[NCT02916927] | Phase 4 | 62 participants (Actual) | Interventional | 2016-09-30 | Completed | ||
| Initiating Ketamine in Acutely Suicidal Patients in the Emergency Department[NCT04260607] | Phase 3 | 2 participants (Actual) | Interventional | 2020-01-14 | Terminated (stopped due to As a busy MTF we were unable to retain a health care provider with the appropriate expertise to buy-in to this study once the initiating PI left military service.) | ||
| Comparison of Ketamine 0.1 mg/kg, 0.2 mg/kg, and 0.3 mg/kg Intravenous Doses for Acute Pain in the Emergency Department: A Prospective, Randomized, Double-blind, Active-controlled, Clinical Trial[NCT03896230] | Phase 4 | 11 participants (Actual) | Interventional | 2019-05-03 | Terminated (stopped due to Due to resource limitations the study was on hold and was then terminated.) | ||
| Patient Satisfaction With Subdissociative Dose Ketamine Versus Morphine for Emergency Department Pain Control[NCT04698772] | 32 participants (Actual) | Observational | 2019-12-19 | Completed | |||
| Analgesic Effects of Low-dose S-ketamine in Patients Undergoing Major Spine Fusion Surgery: A Double-blinded, Randomized Controlled Trial[NCT04964219] | Phase 4 | 164 participants (Anticipated) | Interventional | 2022-02-08 | Recruiting | ||
| The Effect and Contribution of a Perioperative Ketamine Infusion in an Established Enhanced Recovery Pathway[NCT04625283] | Phase 4 | 1,544 participants (Anticipated) | Interventional | 2021-04-12 | Enrolling by invitation | ||
| A Randomized Controlled Trial of Intranasal Sub-dissociative Dosing of Ketamine Compared to Intranasal Fentanyl for Treatment of Pain Associated With Acute Extremity Injuries in Children[NCT02778880] | Phase 3 | 90 participants (Actual) | Interventional | 2016-03-31 | Completed | ||
| A Double Blind, Placebo Controlled, Fixed-Flexible Dose Clinical Trial of Guanfacine Extended Release for the Reduction of Aggression and Self-injurious Behavior Associated With Prader-Willi Syndrome[NCT05657860] | Phase 4 | 33 participants (Anticipated) | Interventional | 2020-12-17 | Recruiting | ||
| Prehospital Analgesia With Intra-Nasal Ketamine[NCT02753114] | Phase 4 | 120 participants (Actual) | Interventional | 2017-11-06 | Completed | ||
| An Open-Label Clinical Trial of Simultaneous Administration of Oral Aspirin and Ketamine as Adjunct to Oral Antidepressant Therapy in Treatment-Resistant Depression[NCT05615948] | Phase 4 | 20 participants (Anticipated) | Interventional | 2022-12-06 | Recruiting | ||
| Comparison of Sub-dissociative Dose Intranasal Ketamine to Intranasal Fentanyl for Treatment of Moderate to Severe Pain in Pediatric Patients Presenting to the Emergency Department: a Prospective, Randomized, Double-blind Study[NCT02388321] | Phase 4 | 22 participants (Actual) | Interventional | 2015-05-01 | Terminated (stopped due to Patients meeting inclusion criteria was low, and PI went to another institution.) | ||
| Ketamine For Acute Treatment of Pain in Emergency Department[NCT02306759] | Phase 4 | 60 participants (Actual) | Interventional | 2015-01-31 | Completed | ||
| Comparing the Effectiveness of Low-dose Ketamine With Morphine to Treat Pain in Patients With Long Bone Fractures[NCT02430818] | 13 participants (Actual) | Interventional | 2015-04-30 | Terminated (stopped due to were not able to enroll patients to a satisfactory level) | |||
| Adjuvant Low-dose Ketamine in Pediatric Sickle Cell Vaso-occlusive Crisis (AKTSS)[NCT03296345] | Phase 2 | 62 participants (Actual) | Interventional | 2016-06-30 | Completed | ||
| A Randomized Controlled Trial to Determine the Efficacy of Ketamine as an Adjunct for Pain Management in Patients With Sickle Cell Crisis[NCT03502421] | Phase 3 | 0 participants (Actual) | Interventional | 2018-09-01 | Withdrawn (stopped due to Never IRB approved, no intention to proceed with the study) | ||
| Ketamine Infusion for Acute Sickle Cell crisiS in the Emergency Department[NCT02417298] | 12 participants (Actual) | Interventional | 2015-11-30 | Terminated (stopped due to Feasibility) | |||
| Music as a Potential Intervention to Improve Hemodynamic Tolerability of Repetitive Sub-Anesthetic IV Ketamine Infusions in Bipolar and Unipolar Depression: A Pilot Study[NCT04701866] | 32 participants (Actual) | Interventional | 2021-01-11 | Completed | |||
| (2R,6R)-Hydroxynorketamine a Novel Therapeutic Analgesic for the Treatment of Neuropathic Pain: A Randomized Double Blind Cross-Over Trial.[NCT05864053] | Phase 1/Phase 2 | 25 participants (Anticipated) | Interventional | 2024-01-31 | Not yet recruiting | ||
| Inhaled Nebulised S(+)-Ketamine for Postoperative Analgesia[NCT02397356] | Phase 4 | 0 participants (Actual) | Interventional | 2018-08-31 | Withdrawn (stopped due to Lack of study personnel) | ||
| A Randomized, Clinical Trial of Oral Midazolam Plus Placebo Versus Oral Midazolam Plus Oral Ketamine for Sedation During Laceration Repair[NCT01470157] | Phase 4 | 60 participants (Anticipated) | Interventional | 2011-07-31 | Recruiting | ||
| A Combination Study With Sub-Dissociative Ketamine and Fentanyl to Treat Moderate to Severe Pain in the Emergency Department[NCT03959852] | Phase 4 | 6 participants (Actual) | Interventional | 2019-11-18 | Terminated (stopped due to Residency completed.) | ||
| Antipruritic Effect of Topical Ketamine, Amitriptyline, and Lidocaine[NCT03096444] | Phase 2 | 13 participants (Actual) | Interventional | 2017-05-23 | Terminated (stopped due to Efficacy was not seen after interim analysis) | ||
| IN Dexmedetomidine for Procedural Sedation in Pediatric Closed Reductions for Distal Forearm Fractures. Timmons Z MD, Feudale B MD Children Presenting to the ED With Distal Forearm Extremity Fractures Often Require Re-alignment Under Conscious Sedation. T[NCT03466242] | Early Phase 1 | 40 participants (Anticipated) | Interventional | 2018-05-01 | Not yet recruiting | ||
| Pilot Study on the Assessment of Motor Imaging Skills in Patients With Complex Regional Pain Syndrome (CRPS)[NCT04703348] | 129 participants (Actual) | Interventional | 2021-01-12 | Completed | |||
| Comparison of Gut Microbial Composition and Function in CRPS Patients vs. Healthy Individuals[NCT05473338] | 250 participants (Anticipated) | Observational | 2022-04-14 | Active, not recruiting | |||
| Comparison of Intravenous Push Dose of Low Dose Ketamine to Short Infusion of Low Dose Ketamine for Treatment of Moderate to Severe Pain in the Emergency Department: A Prospective, Randomized, Double-Blind Study[NCT02363270] | 48 participants (Actual) | Interventional | 2015-04-01 | Completed | |||
| Intraoperative Low-dose Ketamine Infusion as the Main Analgesic in Burn Patients[NCT03049930] | Phase 4 | 46 participants (Anticipated) | Interventional | 2018-02-27 | Recruiting | ||
| Low-Dose Ketamine Versus Morphine for Moderate to Severe Pain in the Emergency Department Geriatric Population: A Prospective, Randomized, Double-Blind Study.[NCT02673372] | Phase 4 | 60 participants (Actual) | Interventional | 2016-04-30 | Completed | ||
| Prospective Observational Evaluation of a New Protocol for Adult Procedural Sedation With Ketamine-propofol in a 1 on 4 Ratio at the Emergency Department of a Tertiary Hospital[NCT04028141] | 61 participants (Actual) | Observational | 2018-02-01 | Completed | |||
| Randomized Controlled Trial of Intranasal Ketamine Compared to Intranasal Fentanyl for Analgesia in Children With Suspected, Isolated Extremity Fractures in the Pediatric Emergency Department[NCT02521415] | Phase 2 | 87 participants (Actual) | Interventional | 2015-12-31 | Completed | ||
| Intranasal Ketamine for Acute Traumatic Pain in the Emergency Department: A Prospective, Randomized Clinical Trial of Efficacy and Safety[NCT02817477] | Phase 4 | 90 participants (Actual) | Interventional | 2012-09-30 | Completed | ||
| A Pilot Study of the Use of Oral Ketamine for Treatment of Vaso-Occlusive Pain in Adolescents and Young Adults[NCT05378555] | Phase 3 | 10 participants (Anticipated) | Interventional | 2023-05-01 | Recruiting | ||
| Treatment of Severe Mucositis Pain With Oral Ketamine Mouthwash[NCT01566448] | Phase 2 | 30 participants (Actual) | Interventional | 2012-02-29 | Completed | ||
| ED Treatment of Suicidal Patients With Ketamine Infusion[NCT03502551] | Phase 2 | 0 participants (Actual) | Interventional | 2019-04-01 | Withdrawn (stopped due to Trial never received funding.) | ||
| Will Warm Patch on the Injecting Site Decrease the Injection Pain Induced by Propofol[NCT04555980] | 120 participants (Actual) | Interventional | 2020-03-20 | Completed | |||
| Comparison of Ultrasound Guided Femoral Nerve Blockade and Standard Parenteral Opioid Pain Management Alone in Patients With Hip Fracture in the Emergency Department[NCT02381717] | 60 participants (Anticipated) | Interventional | 2015-08-31 | Recruiting | |||
| Managing Acute Pain in Critically Ill Non-communicative Palliative Care Patients[NCT02127086] | 377 participants (Actual) | Interventional | 2015-03-31 | Completed | |||
| Analgesic Effect of Ketamine in Patients Undergoing Hysteroscopic Endometrial Thermal Ablation Surgery[NCT01106846] | 22 participants (Actual) | Interventional | 2010-03-31 | Terminated (stopped due to Resources not available to complete.) | |||
| Oral Ketamine for Control of Chronic Pain in Children[NCT01369680] | Phase 1 | 12 participants (Actual) | Interventional | 2011-05-31 | Completed | ||
| Changes of the Short Portable Mental Status Questionnaire (SPMSQ-E) After Ketamine Administration on Ophthalmic Surgery in Geriatric Population.[NCT02049411] | Phase 2 | 80 participants (Actual) | Interventional | 2013-06-30 | Completed | ||
| Ketofol Versus Fentofol for Procedural Sedation of Children 3 to 17 Years Old: a Double-Blind Randomized Controlled Trial[NCT02079090] | Phase 3 | 30 participants (Actual) | Interventional | 2014-07-31 | Completed | ||
| Optimal Lidocaine Propofol Mixture for Painless Induction of Anesthesia[NCT05898061] | 100 participants (Anticipated) | Observational [Patient Registry] | 2023-03-01 | Recruiting | |||
| Low Dose Ketamine Versus Morphine for Moderate to Severe Pain in the Emergency Department: A Prospective, Randomized, Double-Blind Study[NCT01835262] | Phase 4 | 90 participants (Actual) | Interventional | 2013-04-30 | Completed | ||
| Prospective Longitudinal Study on the Treatment Outcomes of Various Treatment Modalities Under a Standardized Treatment Protocol in Patients Suffered Substance Abuse Related Voiding Dysfunction[NCT03913819] | 1,000 participants (Anticipated) | Observational | 2011-12-10 | Recruiting | |||
| Virtual Reality for Alleviation of Peripheral IV Placement-Associated Discomfort[NCT03740607] | 100 participants (Anticipated) | Interventional | 2019-03-01 | Recruiting | |||
| Low Dose Ketamine Infusion for Comorbid Posttraumatic Stress Disorder and Chronic Pain Patients[NCT04322968] | Phase 3 | 41 participants (Actual) | Interventional | 2018-01-09 | Completed | ||
| Nitrous Oxide as Treatment for Fibromyalgia[NCT05357066] | Phase 2 | 50 participants (Anticipated) | Interventional | 2021-11-12 | Recruiting | ||
| The Check Trial: A Comparison of Headache Treatment in the ED: Compazine Versus Ketamine. A Multi-Center, Randomized Double-Blind, Clinical Control Trial.[NCT02657031] | Phase 4 | 54 participants (Actual) | Interventional | 2016-03-17 | Completed | ||
| Comparison of N2O Inhalation and Ketamine IV Injection for Sedation in the Treatment of Laceration of Pediatric Patients.[NCT00834730] | Phase 4 | 32 participants (Actual) | Interventional | 2009-01-31 | Completed | ||
| Efficacy of S(+)-Ketamine Administered as a Continuous Infusion for the Control of Postoperative Pain: a Randomized Controlled Trial[NCT02421913] | Phase 4 | 42 participants (Actual) | Interventional | 2012-06-30 | Completed | ||
| Study of the Efficiency of the Ketamine With Low Analgesic Doses, in Association With High Opioids, in the Treatment of the Rebels Pains, in Palliative Phase of the Cancerous Disease[NCT01326325] | Phase 3 | 24 participants (Actual) | Interventional | 2011-07-31 | Completed | ||
| Low-dose Ketamine as Adjuvant Treatment to Morphine in Neuropathic Cancer Pain[NCT01951911] | Phase 3 | 0 participants (Actual) | Interventional | 2013-09-30 | Withdrawn (stopped due to Poor patient recruitment. Vast majority of the patients have exclusions criteria) | ||
| Personalizing Perioperative Morphine Analgesia for Adolescents Undergoing Major Spine Surgeries[NCT01839461] | 137 participants (Actual) | Observational | 2009-07-31 | Completed | |||
| Assessment of the Analgesic Efficacy and Tolerability of the Perioperative Association of the Ketamine With Opiates After Posterior Vertebral Fusion Surgery in Children With Idiopathic Scoliosis[NCT02571491] | Phase 2 | 48 participants (Actual) | Interventional | 2012-01-31 | Completed | ||
| Administration of Acetazolamide to Prevent Remifentanil Induced Hyperalgesia: Randomize Double Blind Clinical Trial[NCT02992938] | Phase 4 | 50 participants (Actual) | Interventional | 2016-12-31 | Completed | ||
| Can Opioid-induced Hyperalgesia be Prevented by Gradual Dose Reduction vs. Abrupt Withdrawal of Remifentanil?[NCT01702389] | Phase 4 | 16 participants (Actual) | Interventional | 2012-10-31 | Completed | ||
| Comparison of Ketamine Versus Co-Administration of Ketamine and Propofol for Procedural Sedation in a Pediatric Emergency Department[NCT01387139] | Phase 3 | 183 participants (Actual) | Interventional | 2011-01-31 | Completed | ||
| Spreading Depolarization and Ketamine Suppression[NCT02501941] | Phase 1 | 10 participants (Actual) | Interventional | 2015-07-31 | Completed | ||
| Phenomics and Genomics of Clinically Relevant Chronic Postsurgical Pain: A Multicenter Prospective Study[NCT04798573] | 10,000 participants (Anticipated) | Observational | 2012-08-03 | Active, not recruiting | |||
| Conscious Dying/Conscious Living: Ketamine-Assisted Psychotherapy (KAP) for Patients at End of Life-A Pilot Study for Palliative and Hospice Care[NCT05214417] | Phase 2 | 120 participants (Anticipated) | Interventional | 2022-05-01 | Not yet recruiting | ||
| PCA Ketamine-Morphine Versus PCA Morphine as Post-Operative Analgesia in Colorectal Surgery.[NCT06010056] | Phase 4 | 60 participants (Actual) | Interventional | 2018-04-05 | Completed | ||
| A Prospective, Randomized, Double-Blind, Controlled Trial Evaluating the Efficacy of Ketamine for Improvement in Postoperative Pain Control After Spinal Fusion for Idiopathic Scoliosis[NCT02651324] | Phase 4 | 50 participants (Anticipated) | Interventional | 2013-05-31 | Active, not recruiting | ||
| Does a Single Intravenous Dose of Ketamine Reduce the Need for Supplemental Opioids in Post-Cesarean Section Patients?[NCT00486902] | 188 participants (Actual) | Interventional | 2006-07-31 | Completed | |||
| Intra-operative Use of Ketamine for Post-Operative Analgesia in Patients Undergoing Hemorrhoidectomy: A Prospective, Randomized Controlled Trial.[NCT04248205] | Phase 4 | 100 participants (Anticipated) | Interventional | 2020-06-15 | Recruiting | ||
| Effect of Perioperative i.v. Low-dose S(+) Ketamine in Patients Undergoing Hemorrhoidectomy[NCT00354029] | Phase 4 | 83 participants (Actual) | Interventional | 2006-08-31 | Completed | ||
| Intranasal Ketamine Versus Subcutaneous Ketamine for Treatment of Post Traumatic Acute Pain in the Emergency Department[NCT05229055] | Phase 2/Phase 3 | 1,000 participants (Anticipated) | Interventional | 2023-04-15 | Recruiting | ||
| Plasma Concentrations of Ketamine and Norketamine in Patients Using Topical Application of 10% Ketamine for Neuropathic Pain.[NCT01385904] | 15 participants (Anticipated) | Observational | 2011-06-30 | Recruiting | |||
| Systemic Absorption of Lidocaine After Ultrasound Guided Hematoma Block for Reduction of Different Types of Pediatric Distal Radius Fractures[NCT04359017] | Phase 4 | 0 participants (Actual) | Interventional | 2020-11-01 | Withdrawn (stopped due to Sponsoring staff have left institution) | ||
| Patient Input Monitoring of Pain in the Emergency Room: Novel Electronic Log (PIMPERNEL). A Randomised Controlled Trial of an Electronic Pain Score Display in Adults in the Emergency Department[NCT03881982] | 105 participants (Actual) | Interventional | 2017-08-03 | Completed | |||
| Low Dose Ketamine as an Adjunct to Opiates for Acute Pain in the Emergency Department[NCT02489630] | Phase 4 | 116 participants (Actual) | Interventional | 2013-09-30 | Completed | ||
| Combination Ketamine and Propofol vs Propofol for Emergency Department Sedation: A Prospective Randomized Trial[NCT01269307] | 99 participants (Actual) | Interventional | 2010-06-30 | Completed | |||
| The Evaluation of the Combination of Magnesium and Lidocaine for the Pretreatment of Pain That is Caused by the Injection of Propofol.[NCT01342510] | Phase 4 | 200 participants (Actual) | Interventional | 2011-04-30 | Completed | ||
| Intravenous Sedation and Analgesia Using Propofol, Fentanyl and Ketamine (PFK) Versus General Anesthesia in Minor Urological Procedures.[NCT04285528] | 200 participants (Actual) | Interventional | 2019-04-17 | Completed | |||
| The Pharmacokinetics of Ketamine in the Breast Milk of Lactating Women: Quantification of Ketamine and Metabolites[NCT04285684] | Early Phase 1 | 4 participants (Actual) | Interventional | 2019-12-20 | Completed | ||
| The Use of Ketamine as Rescue Analgesia in the Recovery Room Following Opioid Administration. A Double-blind Randomised Trial in Postoperative Patients.[NCT00163969] | Phase 4 | 40 participants | Interventional | 2002-04-30 | Completed | ||
| A Safe Ketamine-Based Therapy for Treatment Resistant Depression[NCT01179009] | 20 participants (Actual) | Interventional | 2012-04-30 | Completed | |||
| Evaluation of the Efficiency of a Therapeutic Education Program in Standardized Thermal Cure for Fibromyalgia Patients[NCT02406313] | 152 participants (Actual) | Interventional | 2015-03-31 | Active, not recruiting | |||
| Effects of Perioperative Systemic Ketamine on Development of Long-term Neuropathic Pain After Thoracotomy.[NCT00313378] | Phase 3 | 78 participants (Actual) | Interventional | 2004-04-30 | Completed | ||
| Magnesium Oral Supplementation to Reduce Pain in Patients With Severe Peripheral Arterial Occlusive Disease: The MAG-PAPER Randomized Clinical Trial[NCT02455726] | 150 participants (Anticipated) | Interventional | 2015-09-30 | Not yet recruiting | |||
| Analgesic Efficacy of Ropivacaine Alone or in Combination With Adjuvants on Post-operative Analgesia Following Video-Assisted Thoracoscopic Surgery (VATS) - A Randomized Controlled Trial.[NCT03809442] | Phase 4 | 120 participants (Anticipated) | Interventional | 2019-06-25 | Recruiting | ||
| Ketamine Versus Etomidate for Procedural Sedation for Pediatric Orthopedic Reductions[NCT00596050] | Phase 4 | 50 participants (Actual) | Interventional | 2006-08-31 | Completed | ||
| Efficacy of Memantine in the Treatment of Fibromyalgia: a Double-blind Randomized Trial[NCT01653457] | Phase 3 | 60 participants (Anticipated) | Interventional | 2012-09-30 | Not yet recruiting | ||
| Influence of Sevoflurane and Propofol on Maximum Muscular Strength, Speed of Contraction and Relaxation, in Humans: A Pilot Study[NCT05615025] | Phase 3 | 48 participants (Actual) | Interventional | 2023-01-20 | Completed | ||
| Naloxone Block of Low-dose (Analgetic Dose) Ketamine[NCT00921765] | Phase 4 | 3 participants (Actual) | Interventional | 2009-12-31 | Terminated (stopped due to Problems with patient recruitment) | ||
| Music in Urgent and Emergent Settings (MUES) Trial: Phase Two[NCT02363179] | 1,107 participants (Actual) | Interventional | 2015-05-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Trial Outcomes
Number of Participants Administered Additional Pain Medications
After the procedure, research personnel will ask anesthetist what medications, if any, they gave outside of the study protocol (NCT04871425)
Timeframe: Immediately postoperatively
| Intervention | Participants (Count of Participants) |
|---|---|
| Ketamine | 23 |
| Fentanyl | 30 |
Provider Satisfaction With Anesthesia Assessed by the VAS
After the procedure, research personnel will assess provider's satisfaction with patient's anesthesia on a 100mm visual analog scale. The minimum score is 0mm and the maximum score if 100mm, with higher scores indicating higher satisfaction. (NCT04871425)
Timeframe: Immediately postoperatively
| Intervention | score on a scale (Mean) |
|---|---|
| Ketamine | 90 |
| Fentanyl | 86.8 |
Satisfaction With Anesthesia Assessed by the ISAS
After the procedure, either at time of discharge (if less than 30 minutes) or at 30 minutes (if not yet discharged), research personnel will assess the participant's satisfaction with anesthesia using the Iowa Satisfaction with Anesthesia Scale. This is a validated perioperative anesthesia satisfaction scale with a minimum score of -3 and a maximum score of +3 with higher scores indicating higher satisfaction. (NCT04871425)
Timeframe: At discharge or 30 minutes after the procedure
| Intervention | score on a scale (Mean) |
|---|---|
| Ketamine | 2.4 |
| Fentanyl | 2.2 |
Postoperative Pain Assessed by the VAS
Patients will complete 2 followup surveys asking about their postoperative pain after discharge. This will be assessed on a 100mm visual analog scale. The minimum score is 0mm and the maximum score if 100mm, with higher scores indicating higher pain levels. (NCT04871425)
Timeframe: 24 hours postoperatively and 7 days postoperatively
| Intervention | score on a scale (Mean) | |
|---|---|---|
| Pain post-op day 1 | Pain post-op day 7 | |
| Fentanyl | 22 | 19.1 |
| Ketamine | 24.5 | 18.2 |
Side Effects
The difference in percentage of participants endorsing side effects between each arm of the study over 60 minutes. (NCT02916927)
Timeframe: 0 - 60 minutes
| Intervention | Participants (Count of Participants) |
|---|---|
| Ketamine IV Infusion | 21 |
| Ketamine IV Push | 25 |
How Bothersome Are the Side Effects?
"The difference in how bothersome (0, not bothersome, to 4, very bothersome, on the Side Effect Rating Scale for Dissociative Anesthetics SERSDA) the side effects experienced by participants in each arm of the study are at 5, 10, 15, 20, 30, 45, and 60 minutes.~0 (no side effects), 1 (weak), 2 (moderate), 3 (bothersome) to 4 (very bothersome)" (NCT02916927)
Timeframe: 5, 10, 15, 20, 30, 45, 60 minutes
| Intervention | score on a scale (Mean) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fatigue at 5 minutes | Fatigue at 10 minutes | Fatigue at 15 minutes | Fatigue at 20 minutes | Fatigue at 30 minutes | Fatigue at 45 minutes | Fatigue at 60 minutes | Dizziness at 5 minutes | Dizziness at 10 minutes | Dizziness at 15 minutes | Dizziness at 20 minutes | Dizziness at 30 minutes | Dizziness at 45 minutes | Dizziness at 60 minutes | Headache at 5 minutes | Headache at 10 minutes | Headache at 15 minutes | Headache at 20 minutes | Headache at 30 minutes | Headache at 45 minutes | Headache at 60 minutes | Unreality at 5 minutes | Unreality at 10 minutes | Unreality at 15 minutes | Unreality at 20 minutes | Unreality at 30 minutes | Unreality at 45 minutes | Unreality at 60 minutes | Hearing at 5 minutes | Hearing at 10 minutes | Hearing at 15 minutes | Hearing at 20 minutes | Hearing at 30 minutes | Hearing at 45 minutes | Hearing at 60 minutes | Vision at 5 minutes | Vision at 10 minutes | Vision at 15 minutes | Vision at 20 minutes | Vision at 30 minutes | Vision at 45 minutes | Vision at 60 minutes | Mood at 5 minutes | Mood at 10 minutes | Mood at 15 minutes | Mood at 20 minutes | Mood at 30 minutes | Mood at 45 minutes | Mood at 60 minutes | Discomfort at 5 minutes | Discomfort at 10 minutes | Discomfort at 15 minutes | Discomfort at 20 minutes | Discomfort at 30 minutes | Discomfort at 45 minutes | Discomfort at 60 minutes | Hallucinations at 5 minutes | Hallucinations at 10 minutes | Hallucinations at 15 minutes | Hallucinations at 20 minutes | Hallucinations at 30 minutes | Hallucinations at 45 minutes | Hallucinations at 60 minutes | |
| Ketamine IV Infusion | 0.1 | 0.4 | 0.3 | 0.3 | 0.1 | 0.2 | 0.2 | 0.5 | 0.6 | 0.5 | 0.5 | 0.3 | 0.2 | 0.2 | 0.2 | 0.1 | 0.2 | 0.1 | 0.2 | 0.2 | 0.1 | 0.3 | 0.6 | 0.5 | 0.5 | 0.2 | 0.1 | 0.03 | 0 | 0.2 | 0.1 | 0.2 | 0.1 | 0 | 0 | 0 | 0.1 | 0.1 | 0.1 | 0.1 | 0 | 0 | 0.1 | 0.2 | 0.2 | 0.2 | 0.2 | 0.3 | 0.1 | 0.1 | 0.1 | 0.1 | 0.03 | 0.2 | 0.2 | 0.2 | 0 | 0.1 | 0 | 0.1 | 0.1 | 0 | 0 |
| Ketamine IV Push | 0.2 | 0.3 | 0.2 | 0.2 | 0.2 | 0.1 | 0.3 | 1.4 | 0.9 | 0.7 | 0.6 | 0.2 | 0.2 | 0.2 | 0.1 | 0.2 | 0.3 | 0.2 | 0.2 | 0.3 | 0.2 | 1.6 | 0.9 | 0.4 | 0.1 | 0.03 | 0.03 | 0 | 0.2 | 0.1 | 0.1 | 0.2 | 0.1 | 0 | 0.04 | 0.3 | 0.3 | 0.1 | 0.1 | 0 | 0 | 0 | 0.5 | 0.3 | 0.4 | 0.3 | 0.03 | 0 | 0 | 0.4 | 0.4 | 0.4 | 0.4 | 0.3 | 0.3 | 0.3 | 0.8 | 0.5 | 0.3 | 0.1 | 0 | 0 | 0 |
Reduction in Pain on Numeric Rating Scale.
"The difference in pain numeric rating score (NRS 0-10) experienced by participants in each arm of the study at 5, 10, 15, 20, 30, 45, and 60 minutes.~Pain numeric rating scale from 0 (no pain) to 10 (maximal pain)." (NCT02916927)
Timeframe: 5, 10 , 15, 20, 30, 45, 60 minutes
| Intervention | score on a scale (Mean) | ||||||
|---|---|---|---|---|---|---|---|
| 5 minutes | 10 minutes | 15 minutes | 20 minutes | 30 minutes | 45 minutes | 60 minutes | |
| Ketamine IV Infusion | 6.5 | 5.4 | 4.7 | 4.3 | 4.8 | 5.3 | 5.4 |
| Ketamine IV Push | 2.9 | 2.8 | 3.4 | 3.9 | 4.2 | 4.6 | 4.5 |
Side Effect Severity
The difference in severity of side effects (0 - 4) experienced by participants in each arm of the study at 5, 10, 15, 20, 30, 45, and 60 minutes. 0 indicates no side effects and 4 most severe side effects. (NCT02916927)
Timeframe: 5, 10, 15, 20, 30, 45, 60 minutes
| Intervention | units on a scale (Mean) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fatigue at 5 minutes | Fatigue at 10 minutes | Fatigue at 15 minutes | Fatigue at 20 minutes | Fatigue at 30 minutes | Fatigue at 45 minutes | Fatigue at 60 minutes | Dizziness at 5 minutes | Dizziness at 10 minutes | Dizziness at 15 minutes | Dizziness at 20 minutes | Dizziness at 30 minutes | Dizziness at 45 minutes | Dizziness at 60 minutes | Headache at 5 minutes | Headache at 10 minutes | Headache at 15 minutes | Headache at 20 minutes | Headache at 30 minutes | Headache at 45 minutes | Headache at 60 minutes | Unreality at 5 minutes | Unreality at 10 minutes | Unreality at 15 minutes | Unreality at 20 minutes | Unreality at 30 minutes | Unreality at 45 minutes | Unreality at 60 minutes | Hearing at 5 minutes | Hearing at 10 minutes | Hearing at 15 minutes | Hearing at 20 minutes | Hearing at 30 minutes | Hearing at 45 minutes | Hearing at 60 minutes | Vision at 5 minutes | Vision at 10 minutes | Vision at 15 minutes | Vision at 20 minutes | Vision at 30 minutes | Vision at 45 minutes | Vision at 60 minutes | Mood at 5 minutes | Mood at 10 minutes | Mood at 15 minutes | Mood at 20 minutes | Mood at 30 minutes | Mood at 45 minutes | Mood at 60 minutes | Discomfort at 5 minutes | Discomfort at 10 minutes | Discomfort at 15 minutes | Discomfort at 20 minutes | Discomfort at 30 minutes | Discomfort at 45 minutes | Discomfort at 60 minutes | Hallucinations at 5 minutes | Hallucinations at 10 minutes | Hallucinations at 15 minutes | Hallucinations at 20 minutes | Hallucinations at 30 minutes | Hallucinations at 45 minutes | Hallucinations at 60 minutes | |
| Ketamine IV Infusion | 0.4 | 0.9 | .6 | 0.5 | 0.2 | 0.3 | 0.3 | 0.8 | 1.1 | 1.1 | 1.0 | 0.4 | 0.2 | 0.2 | 0.2 | 0.1 | 0.3 | 0.2 | 0.3 | 0.2 | 0.2 | 0.9 | 1.5 | 1.4 | 1.1 | 0.5 | 0.2 | 0.1 | 0.1 | 0.3 | 0.3 | 0.4 | 0.2 | 0 | 0 | 0.03 | 0.2 | 0.2 | 0.1 | 0.1 | 0 | 0 | 0.8 | 1.2 | 1.4 | 1.2 | 0.9 | 0.6 | 0.3 | 0.1 | 0.1 | 0.1 | 0.2 | 0.1 | 0.2 | 0.2 | 0.03 | 0.1 | 0.03 | 0.1 | 0.1 | 0 | 0 |
| Ketamine IV Push | 0.6 | 0.7 | 0.7 | 0.4 | 0.3 | 0.4 | 0.5 | 2.2 | 1.9 | 1.1 | 0.9 | 0.4 | 0.3 | 0.3 | 0.2 | 0.3 | 0.3 | 0.2 | 0.2 | 0.3 | 0.3 | 2.6 | 2.2 | 1.3 | 0.8 | 0.2 | 0.1 | 0 | 0.6 | 0.2 | 0.2 | 0.1 | 0.1 | 0 | 0.04 | 0.7 | 0.4 | 0.2 | 0.1 | 0.03 | 0 | 0 | 1.7 | 2.3 | 2.0 | 1.2 | 0.6 | 0.3 | 0.1 | 0.4 | 0.4 | 1.0 | 0.4 | 0.3 | 0.2 | 0.3 | 0.9 | 0.7 | 0.4 | 0.1 | 0 | 0 | 0 |
Side Effects
The difference in percentage of participants endorsing side effects between each arm of the study at 5, 10, 15, 20, 30, 45, and 60 minutes. (NCT02916927)
Timeframe: 5, 10, 15, 20, 30, 45, 60 minutes
| Intervention | participants (Number) | ||||||
|---|---|---|---|---|---|---|---|
| 5 minutes | 10 minutes | 15 minutes | 20 minutes | 30 minutes | 45 minutes | 60 minutes | |
| Ketamine IV Infusion | 10 | 17 | 16 | 13 | 13 | 9 | 8 |
| Ketamine IV Push | 20 | 18 | 15 | 12 | 9 | 5 | 5 |
Adverse Events
"Frequency of adverse events secondary to ketamine including fatigue, dizziness, nausea, headache, feeling of unreality, changes in hearing or vision, mood changes, generalized discomfort, and hallucinations, changes in vital signs.~Adverse events were reported at baseline and then at 15 min/30 min/60 min/90 min and 120 minutes post-infusion." (NCT03896230)
Timeframe: Within 2 hours post infusion completion
| Intervention | participants (Number) | ||||
|---|---|---|---|---|---|
| at 15 min post infusion | at 30 min post infusion | at 60 min post infusion | at 90 min post infusion | at 120 min post infusion | |
| Arm 1: 0.1 mg/kg Ketamine | 2 | 1 | 1 | 1 | 1 |
| Arm 1: 0.2 mg/kg Ketamine | 3 | 2 | 2 | 2 | 0 |
| Arm 1: 0.3 mg/kg Ketamine | 2 | 1 | 0 | 0 | 0 |
Pain Score
"Pain score using Numerical Rating Scale (NRS) post ketamine infusion. The Numerical Rating Scale (NRS) ranges from 0-to-10 with 0 being no pain and lower numbers representing less pain, so in this case lower numbers will represent better outcomes.~Pain scores were reported at baseline and then at 15 min/30 min/60 min/90 min and 120 minutes post-infusion." (NCT03896230)
Timeframe: Within 2 hours post infusion completion
| Intervention | score on a scale (Mean) | ||||
|---|---|---|---|---|---|
| Baseline pain score | Pain score at 15 min | Pain score at 30 min | Pain score at 60 min | Pain score at 90 min | |
| Arm 1: 0.3 mg/kg Ketamine | 7.5 | 2 | 6 | 5 | 2 |
| Arm 1: 0.2 mg/kg Ketamine | 8.5 | 6 | 5.75 | 7 | 7 |
Pain Score
"Pain score using Numerical Rating Scale (NRS) post ketamine infusion. The Numerical Rating Scale (NRS) ranges from 0-to-10 with 0 being no pain and lower numbers representing less pain, so in this case lower numbers will represent better outcomes.~Pain scores were reported at baseline and then at 15 min/30 min/60 min/90 min and 120 minutes post-infusion." (NCT03896230)
Timeframe: Within 2 hours post infusion completion
| Intervention | score on a scale (Mean) | |||||
|---|---|---|---|---|---|---|
| Baseline pain score | Pain score at 15 min | Pain score at 30 min | Pain score at 60 min | Pain score at 90 min | Pain score at 120 min | |
| Arm 1: 0.1 mg/kg Ketamine | 9.4 | 5.25 | 5.25 | 5.25 | 4.5 | 4 |
Capnometry Value
(NCT02778880)
Timeframe: 15 minutes after study medication
| Intervention | mmHg (Mean) |
|---|---|
| Ketamine | 36.6 |
| Fentanyl | 38.3 |
Capnometry Value
(NCT02778880)
Timeframe: 30 minutes after study medication
| Intervention | mmHg (Mean) |
|---|---|
| Ketamine | 38.6 |
| Fentanyl | 40.4 |
Capnometry Value
(NCT02778880)
Timeframe: 60 minutes after study medication
| Intervention | mmHg (Mean) |
|---|---|
| Ketamine | 38.7 |
| Fentanyl | 38.9 |
Diastolic Blood Pressure
(NCT02778880)
Timeframe: 15 minutes after study medication
| Intervention | mmHg (Mean) |
|---|---|
| Ketamine | 76.1 |
| Fentanyl | 73.4 |
Diastolic Blood Pressure
(NCT02778880)
Timeframe: 30 minutes after study medication
| Intervention | mmHg (Mean) |
|---|---|
| Ketamine | 76.3 |
| Fentanyl | 73.6 |
Diastolic Blood Pressure
(NCT02778880)
Timeframe: 60 minutes after study medication
| Intervention | mmHg (Mean) |
|---|---|
| Ketamine | 70.8 |
| Fentanyl | 70.6 |
Difference From Baseline in Visual Analog Scale Pain Score
A VAS score is a self reported pain score of 0-100 millimeters (0 = no pain; 100 = worst possible pain). A decrease in a VAS score indicates a decrease in pain severity. (NCT02778880)
Timeframe: 15 minutes after study medication
| Intervention | score on a scale (Mean) |
|---|---|
| Ketamine | -24.4 |
| Fentanyl | -25.3 |
Difference From Baseline in Visual Analog Scale Pain Score
A VAS score is a self reported pain score of 0-100 millimeters (0 = no pain; 100 = worst possible pain). A decrease in a VAS score indicates a decrease in pain severity. (NCT02778880)
Timeframe: 30 minutes after study medication
| Intervention | score on a scale (Mean) |
|---|---|
| Ketamine | -30.6 |
| Fentanyl | -31.9 |
Difference From Baseline in Visual Analog Scale Pain Score
A VAS score is a self reported pain score of 0-100 millimeters (0 = no pain; 100 = worst possible pain). A decrease in a VAS score indicates a decrease in pain severity. (NCT02778880)
Timeframe: 60 minutes after study medication
| Intervention | score on a scale (Mean) |
|---|---|
| Ketamine | -27.7 |
| Fentanyl | -29.0 |
Heart Rate
(NCT02778880)
Timeframe: 15 minutes after study medication
| Intervention | beats per minute (Mean) |
|---|---|
| Ketamine | 90.1 |
| Fentanyl | 84.4 |
Heart Rate
(NCT02778880)
Timeframe: 30 minutes after study medication
| Intervention | beats per minute (Mean) |
|---|---|
| Ketamine | 90.5 |
| Fentanyl | 85.6 |
Heart Rate
(NCT02778880)
Timeframe: 60 minutes after study medication
| Intervention | beats per minute (Mean) |
|---|---|
| Ketamine | 85.1 |
| Fentanyl | 82.9 |
Oxygen Saturation
(NCT02778880)
Timeframe: 15 minutes after study medication
| Intervention | percent (Mean) |
|---|---|
| Ketamine | 99.6 |
| Fentanyl | 99.2 |
Oxygen Saturation
(NCT02778880)
Timeframe: 30 minutes after study medication
| Intervention | percent (Mean) |
|---|---|
| Ketamine | 99.5 |
| Fentanyl | 99.4 |
Oxygen Saturation
(NCT02778880)
Timeframe: 60 minutes after study medication
| Intervention | percent (Mean) |
|---|---|
| Ketamine | 99.3 |
| Fentanyl | 99.3 |
Respiratory Rate
(NCT02778880)
Timeframe: 15 minutes after study medication
| Intervention | breaths per minute (Mean) |
|---|---|
| Ketamine | 23.1 |
| Fentanyl | 22.3 |
Respiratory Rate
(NCT02778880)
Timeframe: 30 minutes after study medication
| Intervention | breaths per minute (Mean) |
|---|---|
| Ketamine | 23.3 |
| Fentanyl | 19.9 |
Respiratory Rate
(NCT02778880)
Timeframe: 60 minutes after study medication
| Intervention | breaths per minute (Mean) |
|---|---|
| Ketamine | 21.8 |
| Fentanyl | 19.7 |
Systolic Blood Pressure
(NCT02778880)
Timeframe: 15 minutes after study medication
| Intervention | mmHg (Mean) |
|---|---|
| Ketamine | 127.3 |
| Fentanyl | 127.9 |
Systolic Blood Pressure
(NCT02778880)
Timeframe: 30 minutes after study medication
| Intervention | mmHg (Mean) |
|---|---|
| Ketamine | 126.3 |
| Fentanyl | 123.4 |
Systolic Blood Pressure
(NCT02778880)
Timeframe: 60 minutes after study medication
| Intervention | mmHg (Mean) |
|---|---|
| Ketamine | 122.3 |
| Fentanyl | 122.0 |
Adverse Events at 30 Minutes
The patient were asked at 30 minutes post administration of analgesia if they experienced any side effects like nausea, vomiting, headache etc. (NCT02388321)
Timeframe: 30 minutes
| Intervention | Participants (Count of Participants) |
|---|---|
| Ketamine | 0 |
| Fentanyl | 0 |
Pain Score at 30 Minutes
An 11 point Likert Visual Analog Scale with 0 being no pain, 5 being moderate pain and 10 being very severe pain was verbally administered to the patient at 30 minutes post administration of analgesia. (NCT02388321)
Timeframe: 30 minutes
| Intervention | units on a scale (Mean) |
|---|---|
| Ketamine | 3.36 |
| Fentanyl | 2.09 |
Change From Baseline of Pain as Described by Numeric Rating Scale (NRS) [Minimum:0, Maximum 10] at 15 Minutes
Change from Baseline of Pain as described by Numeric Rating Scale (NRS) [minimum:0, maximum 10] at 15 minutes. Lower values indicate worst outcomes while higher values indicate better outcomes. (NCT02306759)
Timeframe: 15 minutes after administration of study intervention
| Intervention | units on a scale (Median) |
|---|---|
| Treatment | 3.5 |
| Placebo | 6.0 |
ED Length of Stay (Minutes)
ED Length of stay (minutes) throughout study period (NCT02306759)
Timeframe: throughout study completion
| Intervention | minutes (Mean) |
|---|---|
| Treatment | 267 |
| Placebo | 292 |
Number of Participants With Adverse Events
Incidence or number of participants with adverse events. (NCT02306759)
Timeframe: during the study period
| Intervention | participants (Number) |
|---|---|
| Treatment | 2 |
| Placebo | 4 |
Patient Satisfaction of Pain Control Based on a Likert Scale
Patient satisfaction of pain control based on a Likert Scale at the end of study completion, an average of 90 minutes. Scores reported out of scale of 10, 10 being most satisfied and 1 being least satisfied. (NCT02306759)
Timeframe: At the end of study period
| Intervention | units on a scale (Mean) |
|---|---|
| Treatment | 8.57 |
| Placebo | 6.05 |
Mean Consumption of Rescue Analgesia
(NCT02306759)
Timeframe: at designated intervals during study period (0, 15, 30, 45, 60, 75, 90, 105, 120 minutes)
| Intervention | milligrams (Mean) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| T5 | T15 | T30 | T45 | T60 | T75 | T90 | T105 | T120 | |
| Placebo | 0 | 0.14 | 0.28 | 0 | 0.22 | 0 | 0 | 0.42 | 0.42 |
| Treatment | 0 | 0.23 | 0.37 | 0.07 | 0 | 0 | 0.48 | 0.55 | 0 |
Number of Participants With an Adverse Effects
We will monitor for adverse effects and record for changes in vital signs including nausea and vomiting, hypotension, respiratory depression, laryngospasm, and emotional and psychological effects (emergence reactions). (NCT02430818)
Timeframe: 60 minutes
| Intervention | participants (Number) |
|---|---|
| Ketamine | 1 |
| Morphine | 1 |
Pain Treatment-VAS (Visual Analog Scale)
Study outcomes involve change in participants' pain as measured by a visual analog scale. The scale is a 10 inch line from 0 to 10 inches with 10 being the most pain and 0 being no pain. There are no units on the scale; it is just a straight line from no pain (0) to the worst pain (10). We assessed at o, 15, and 60 minutes but only scored the VAS at 60 minutes. (NCT02430818)
Timeframe: At 0 minutes and 60 minutes
| Intervention | score on a scale (Median) |
|---|---|
| Ketamine | 4 |
| Morphine | 4 |
Would the Participant Would Consider Using the Drug Given to Them for Pain Relief in the Future
Patients will be assessed to determine whether the participant would consider using the drug given to them for pain relief in the future. It was measured on a likert scale from 1-5 with 1 being did not like and would not use the drug again to 5 being like and would definitely receive the medication again. There are no units. The numbers below are the total number of patients that completed this answer. This was only asked on patients that received medication as if they did not receive medication the answer would not make sense. The median value is the likert value on a scale of 1-5 with the standard deviation. (NCT02430818)
Timeframe: 60 minutes
| Intervention | units on a scale (Median) |
|---|---|
| Ketamine | 4 |
| Morphine | 4 |
Effect of Low-dose Ketamine (LDK) on Opioid Usage in the ED
Opioid usage for at least one but up to three prior patient visits in the last one year for each patient enrolled in the study was summarized, expressed as morphine equivalents in mg/kg/h, to account for different types of opioids used per patient preference, and then this was compared to the intervention group that received LDK. Percent change in opioid usage (expressed as morphine equivalents in mg/kg/h) is reported). (NCT03296345)
Timeframe: Up to one year prior and after LDK administration on day 1 of the study in the ED
| Intervention | percent change (Mean) |
|---|---|
| Intervention | -15 |
Effect of Low-dose Ketamine on Discharge Rates From the ED
"Percent discharge from the ED for intervention group and for at least one but up to three visits prior to receipt of ketamine in the last one year, were assessed. Participants were assigned a 0 if discharged or 1 if not discharged." (NCT03296345)
Timeframe: Up to one year prior to receipt of ketamine for the historical control arm/group and up to 18 months for the intervention arm/group
| Intervention | percentage of participants (Number) |
|---|---|
| Intervention | 33 |
| Historical Control | 17 |
Effect of Low-dose Ketamine on Pain Scores on Presentation to the ED
Patient pain scores at presentation for the enrolled encounters and for at least one but up to three visits prior to receipt of ketamine in the last one year, were assessed. At least one but up to three prior visits were averaged and compared to the intervention visit. Pain was assessed using the faces pain scale which consists of a series of line diagrams of faces with expressions of increasing distress. The score ranges from 0 (no pain) to 10 (the worst pain). (NCT03296345)
Timeframe: Up to one year prior and on presentation to the ED after LDK administration
| Intervention | Score on a scale (Mean) |
|---|---|
| Intervention | 9.23 |
| Historical Control | 9.08 |
Effect of Low-dose Ketamine on Patient Pain Scores on Discharge From the ED/Admission to the Hospital
Patient pain scores at time of discharge from the ED/admission to the hospital for at least one but up to three visits prior to receipt of ketamine in the last one year, were assessed. At least one but up to three prior visits were averaged and compared to the intervention visit. Pain scores post receipt of ketamine are presented for the intervention group. Pain was assessed using the faces pain scale which consists of a series of line diagrams of faces with expressions of increasing distress. The score ranges from 0 (no pain) to 10 (the worst pain). (NCT03296345)
Timeframe: At time of discharge from the ED/admission to the hospital (up to one year prior and after LDK administration)
| Intervention | Score on a scale (Mean) |
|---|---|
| Intervention | 7.15 |
| Historical Control | 7.26 |
Effect of Low-dose Ketamine on Percent Difference of Length of Stay (LOS) in the ED
Length of stay (LOS) in minutes in the ED for at least one but up to three visits prior to receipt of ketamine in the last one year, were assessed. (NCT03296345)
Timeframe: Up to one year prior to and after LDK administration on day 1 of the study in the ED
| Intervention | LOS in minutes (Mean) |
|---|---|
| Intervention | 273.5 |
| Historical Control | 217.3 |
Effect of Low-dose Ketamine on Time to 50% Pain Reduction
Time to 50% pain reduction (pain reported 50% less than baseline) in minutes for at least one but up to three visits prior to receipt of ketamine in the last one year, were assessed as historical controls. Pain was assessed using the faces pain scale which consists of a series of line diagrams of faces with expressions of increasing distress. The score ranges from 0 (no pain) to 10 (the worst pain). (NCT03296345)
Timeframe: Up to one year prior to and after LDK administration on day 1 of the study in the ED
| Intervention | time to 50% pain reduction in minutes (Mean) |
|---|---|
| Intervention | 116.1 |
| Historical Control | 167.3 |
Subjective Effect of Low Dose Ketamine on Pain Relief Assessed Via a Patient Survey
"After receipt of LDK, patients and/or their parents, based on age, filled out a survey based on a Likert scale regarding their agreement (Strongly Disagree to Strongly Agree) with the following statements: Achieved faster pain relief with LDK, Achieved more complete pain relief with LDK, and Desire to receive LDK in a future vaso-occlusive crisis. There is also an area where patients could provide general comments regarding their experience in receiving LDK.~Count of Participants who agree or strongly agree for each question are reported." (NCT03296345)
Timeframe: after LDK administration on day 1 of the study in the ED
| Intervention | Participants (Count of Participants) | ||
|---|---|---|---|
| Achieved faster pain relief? | Achieved more complete pain relief? | Desire to receive LDK in the future? | |
| Intervention | 43 | 30 | 49 |
Peak Itch Intensity Between the Vehicle and Active Treatments (Individual and KeAmLi-combo).
"Peak itch intensity between the vehicle and 4 other active treatments (individual ketamine, amitriptyline, or lidocaine, and KeAmLi-combo). Itch intensity was measured on a 100mm scale visual analog scale for 10 minutes. 0 was weighted with no itch and 100 was weighted with most itch imaginable." (NCT03096444)
Timeframe: 10 minutes
| Intervention | Intensity score (Mean) |
|---|---|
| Topical KeAmLi Combo | 62.7 |
| Topical Ketamine | 63.1 |
| Topical Amitriptyline | 69.2 |
| Topical Lidocaine | 65.8 |
| Topical Vehicle | 61.9 |
Mechanical Thresholds (Mechanical Detection and Pain).
Assess mechanical detection and pain thresholds using von Frey filaments stimulators (measured in force mN) to calculate the final threshold as the geometric mean of five series of ascending and descending stimuli. (NCT03096444)
Timeframe: 5 minutes
| Intervention | mN (Mean) | |
|---|---|---|
| Mechanical Detection Threshold | Mechanical Pain Threshold | |
| Topical Amitriptyline | 3.573423965 | 152.4768146 |
| Topical KeAmLi Combo | 3.519376956 | 152.3293608 |
| Topical Ketamine | 3.464204768 | 135.9 |
| Topical Lidocaine | 3.546037659 | 126.9 |
| Topical Vehicle | 3.525692637 | 148.7138273 |
Thermal Threshold Detection (Warmth and Heat Pain)
Two standardized quantitative sensory tests are performed to measure warmth detection threshold (assesses the threshold of which warmth sensation is first detected) and heat pain threshold (assesses the threshold at which heat pain sensation is first detected). Measured in change in celsius. (NCT03096444)
Timeframe: 3 minutes
| Intervention | Degrees celsius (Mean) | |
|---|---|---|
| Warm Detection Threshold | Heat Pain Threshold | |
| Topical Amitriptyline | 33.9 | 40.0 |
| Topical KeAmLi Combo | 33.6 | 39.8 |
| Topical Ketamine | 34.0 | 40.0 |
| Topical Lidocaine | 33.7 | 39.4 |
| Topical Vehicle | 33.8 | 39.7 |
Overall Rate of Feeling Unreality
Overall rate of feeling of unreality as measured by Side Effects Rating Scale for Dissociative Anesthetics (SERSDA) (NCT02363270)
Timeframe: 30 minutes
| Intervention | Participants (Count of Participants) |
|---|---|
| IV Push Group | 22 |
| IV Drip Group | 13 |
Reduction of Pain Score at 30 Minutes
The primary outcome will be the comparative reduction of NRS pain scores between the 2 groups at 30 minutes. The NRS Pain scale ranges from 0 to 10 (0 being no pain at all to 10 being very severe pain; 5 is moderate pain) (NCT02673372)
Timeframe: 30 minutes
| Intervention | score on a scale (Mean) |
|---|---|
| Morphine Group | 4.4 |
| Ketamine Group | 4.2 |
Exploratory Outcome: Reduction in Age Appropriate Pain Scale Scores
Mean difference in the reduction of the pain scale scores at 20 minutes. Two commonly used, age appropriate and previously validated, pediatric pain assessment tools were used: FACES Pain Scale - Revised for children ages 4-10 and the Visual Analog Scale for children ages 11-17. The FACES Pain Scale - Revised is a self-reported measure of pain intensity developed for children with pain intensity represented by images of grimacing faces on a scale of 0 (no pain) to 10 (maximum pain). The Visual Analog Scale is a self-reported measure of pain intensity where patients mark their pain level on a 10 cm line that represents a continuum of no pain at 0 cm and worst pain at 10 cm. For analysis, pain scale data were merged and reported as values form 0 to 100. The minimum clinically significant reduction in pain was defined as a decrease of 20. (NCT02521415)
Timeframe: 20 minutes
| Intervention | units on a scale (Mean) |
|---|---|
| Ketamine | 44 |
| Fentanyl | 35 |
Secondary Outcome: Total Dose of Opioid Pain Medication in Morphine Equivalents/kg/Hour
Compare the total dose of opioid pain medication in morphine equivalents/kg/hour required during the ED evaluation of children with suspected forearm fractures after randomization and treatment with IN ketamine or IN fentanyl. (NCT02521415)
Timeframe: participants will be followed during the emergency department length of stay, estimated to average 6 hours
| Intervention | morphine equivalents/kg/hr (Median) |
|---|---|
| Ketamine | 0.04 |
| Fentanyl | 0.05 |
Change in Pain Scores
Change in pain score as reported at baseline and after the use of ketamine mouthwash on a numeric scale from 0 to 10, with 0 representing no pain and 10 representing the worst pain. (NCT01566448)
Timeframe: 1 hour after baseline
| Intervention | score on a scale (Median) |
|---|---|
| Ketamine | 2 |
Change in Sleep Quality
Sleep quality, as reported by the subject on a numeric scale (1-10) will be used as a surrogate marker of quality of life with 0 indicating no sleep and 10 indicating the best sleep you have had. (NCT01566448)
Timeframe: Day 1 after start of ketamine mouthwashes
| Intervention | score on a scale (Median) |
|---|---|
| Ketamine | 1 |
Change in Topical Lidocaine Usage
Change of topical lidocaine uses in 24 hour period (NCT01566448)
Timeframe: Days 1 after start of ketamine mouthwashes
| Intervention | lidocaine doses per day (Median) |
|---|---|
| Ketamine | 1 |
Change in Use of Narcotic Analgesics
Change in IV morphine equivalents of opioid requirements (NCT01566448)
Timeframe: Days 1 after start of ketamine mouthwashes
| Intervention | IV morphine equivalents (Median) |
|---|---|
| Ketamine | 12 |
Quality of Recovery Score Post Operative at 24 Hours
Quality of recovery 40 score at 24 hours after the surgical procedure. 40 being a poor recovery and 200 being a good recovery. (NCT01106846)
Timeframe: 24 hours post operative
| Intervention | units on scale (Mean) |
|---|---|
| Group A: Saline Group | 191.2 |
| Group B: 1% Ketamine Group | 191.1 |
Neurocognitive Effect
"Baseline neurocognitive testing will be done before study drug is given. Subjects will be reassessed for any changes in neurocognitive scores at end of dosing (week 2) and at three weeks off study drug (week 14). Significant changes were measured at week 14 compared to baseline. Week 2 was measured to inform future studies.~The neurocognitive scores are standardized scores with a mean of 100; low scores correlate with low neurocognitive function, while high scores correlate with high function. A significant change is defined as greater than or equal to 10% decrease in scores." (NCT01369680)
Timeframe: At 14 weeks
| Intervention | participants (Number) |
|---|---|
| Ketamine 0.25 mg/kg/Dose | 0 |
| Ketamine 0.5 mg/kg/Dose | 0 |
| Ketamine 1 mg/kg/Dose | 0 |
| Ketamine 1.5 mg/kg/Dose | 0 |
Norketamine Cmax (Measured in ng/mL).
Pharmacokinetic testing will be done during chronic ketamine administration on subjects consenting to additional testing one week into study drug administration. This is to further describe the activity of ketamine in the blood of children when administered chronically and to enable comparison of any clinical effect or toxicity with steady state levels of ketamine in children. (NCT01369680)
Timeframe: At week 1
| Intervention | ng/mL (Mean) |
|---|---|
| Ketamine 0.25 mg/kg/Dose | 37.5 |
| Ketamine 0.5 mg/kg/Dose | 135 |
| Ketamine 1 mg/kg/Dose | 250 |
Number of Participants Tolerating Dose
According to CTCae any dose causing grade 2 or worse toxicity will be an untolerated dose. Tolerability is defined as ability to take the medication for 2 weeks without having a grade 2 or worse toxicity. (NCT01369680)
Timeframe: Up to 2 weeks
| Intervention | participants (Number) |
|---|---|
| Ketamine 0.25 mg/kg/Dose | 3 |
| Ketamine 0.5 mg/kg/Dose | 3 |
| Ketamine 1 mg/kg/Dose | 3 |
| Ketamine 1.5 mg/kg/Dose | 1 |
Pain Control
"Subjects will be assessed for clinically significant change in pain scores during and after study drug administration. Significant change in pain scores were determined at week 2, though week 14 scores were collected as well.~Participants with a 2 point (or greater) decrease in pain scores compared to baseline were considered to have responded. The NRS scale was used, the scale ranges from 0-10, with 10 being the most pain." (NCT01369680)
Timeframe: Week 2
| Intervention | participants (Number) |
|---|---|
| Ketamine 0.25 mg/kg/Dose | 3 |
| Ketamine 0.5 mg/kg/Dose | 0 |
| Ketamine 1 mg/kg/Dose | 2 |
| Ketamine 1.5 mg/kg/Dose | 0 |
Numeric Rating Scale of Pain
"We will compare efficacy as a difference between 2 groups in pain score at 30 minutes post-analgesic administration. The primary outcome is the difference between 2 groups in pain score at 30 minutes.~Pain will be measured via Numeric rating scale from 0 to 10 with 0 being no pain, 5 being moderate pain, and 10 being severe pain" (NCT01835262)
Timeframe: 30 minutes
| Intervention | Units on a scale (Mean) |
|---|---|
| Morphine | 3.93 |
| Ketamine Group | 4.07 |
Impact of Event Scale-Revised (IES-R)
"Severity of PTSD symptoms; items are rated on a 5-point scale ranging from 0 (not at all) to 4 (extremely). The IES-R yields a total score (ranging from 0 to 88); higher scores mean worse symptoms" (NCT04322968)
Timeframe: 1 week post-infusion
| Intervention | units on a scale (Mean) |
|---|---|
| Chronic Pain With PTSD+IV Ketamine Infusion | 28.22 |
| Chronic Pain With PTSD+IV Ketorolac Infusion | 33.66666667 |
| Chronic Pain Without PTSD+IV Ketamine Infusion | 11.44 |
| Chronic Pain Without PTSD+IV Ketorolac Infusion | 13.41 |
Impact of Event Scale-Revised (IES-R)
"Severity of PTSD symptoms; items are rated on a 5-point scale ranging from 0 (not at all) to 4 (extremely). The IES-R yields a total score (ranging from 0 to 88); higher scores mean worse symptoms" (NCT04322968)
Timeframe: 24 hrs post-infusion
| Intervention | units on a scale (Mean) |
|---|---|
| Chronic Pain With PTSD+IV Ketamine Infusion | 36.33333333 |
| Chronic Pain With PTSD+IV Ketorolac Infusion | 37 |
| Chronic Pain Without PTSD+IV Ketamine Infusion | 10.44444444 |
| Chronic Pain Without PTSD+IV Ketorolac Infusion | 15.64705882 |
Visual Analogue Scale (VAS)
"Severity of chronic pain symptoms; using a ruler, the score is determined by measuring the distance (mm) on the 10-cm line between the no pain anchor and the patient's mark, providing a range of scores from 0-100; a higher score indicates greater pain intensity." (NCT04322968)
Timeframe: 1 week post-infusion
| Intervention | units on a scale (Mean) |
|---|---|
| Chronic Pain With PTSD+IV Ketamine Infusion | 48.22 |
| Chronic Pain With PTSD+IV Ketorolac Infusion | 52.88 |
| Chronic Pain Without PTSD+IV Ketamine Infusion | 43.33 |
| Chronic Pain Without PTSD+IV Ketorolac Infusion | 48.23 |
Visual Analogue Scale (VAS)
"Severity of chronic pain symptoms; using a ruler, the score is determined by measuring the distance (mm) on the 10-cm line between the no pain anchor and the patient's mark, providing a range of scores from 0-100; a higher score indicates greater pain intensity." (NCT04322968)
Timeframe: 24 hrs post-infusion
| Intervention | units on a scale (Mean) |
|---|---|
| Chronic Pain With PTSD+IV Ketamine Infusion | 37.22222222 |
| Chronic Pain With PTSD+IV Ketorolac Infusion | 49.66666667 |
| Chronic Pain Without PTSD+IV Ketamine Infusion | 29.88888889 |
| Chronic Pain Without PTSD+IV Ketorolac Infusion | 38.70588235 |
Brief Pain Inventory (Short Form)
"Severity of pain, impact of pain on daily function, location of pain, pain medications and amount of pain relief in the past 24 hours or the past week; No scoring algorithm, but worst pain or the arithmetic mean of the four severity items can be used as measures of pain severity (a range of 0-10, with 10 being worse scores); the arithmetic mean of the seven interference items can be used as a measure of pain interference (a range of 0-10, with 10 being worse scores). The total score is reported for severity items and interference items, which range from 0-40 and 0-70, respectively. Higher values represent worse outcome." (NCT04322968)
Timeframe: 1 week post-infusion
| Intervention | units on a scale (Mean) | |
|---|---|---|
| Pain interference Scale | Pain severity Scale | |
| Chronic Pain With PTSD+IV Ketamine Infusion | 38.62 | 20.75 |
| Chronic Pain With PTSD+IV Ketorolac Infusion | 25.66 | 14.66 |
| Chronic Pain Without PTSD+IV Ketamine Infusion | 9.62 | 12.75 |
| Chronic Pain Without PTSD+IV Ketorolac Infusion | 28.33 | 22.66 |
Anxiety
Reduction in 100 mm Visual Analog Scale (VAS) Score. The maximum possible change in VAS score is 100 mm, representing the complete relief of maximum anxiety. A change of 0 mm corresponds to no change in anxiety level, and a negative value indicates worsening of the anxiety after the medication. (NCT02657031)
Timeframe: 0-60 minutes
| Intervention | mm (Mean) |
|---|---|
| Control Arm | 33.7 |
| Study Arm | 21.2 |
Headache Following Intervention
Reduction in 100 mm Visual Analog Scale (VAS) Score. Positive values represent a reduction in headache severity. The maximum possible change in VAS score is 100 mm, representing the complete relief of a maximally severe headache. A change of 0 mm corresponds to no change in headache severity, and a negative value indicates worsening of the headache after the medication. (NCT02657031)
Timeframe: 0-60 minutes
| Intervention | mm (Mean) |
|---|---|
| Control Arm | 63.5 |
| Study Arm | 43.5 |
Nausea
Reduction in 100 mm Visual Analog Scale (VAS) Score. The maximum possible change in VAS score is 100 mm, representing the complete relief of maximum nausea. A change of 0 mm corresponds to no change in nausea level, and a negative value indicates worsening of the nausea after the medication. (NCT02657031)
Timeframe: 0-60 minutes
| Intervention | mm (Mean) |
|---|---|
| Control Arm | 38.9 |
| Study Arm | 22.9 |
The Number of Participants Experiencing Vomiting
Yes/No (NCT02657031)
Timeframe: 0-60 minutes
| Intervention | participants (Number) |
|---|---|
| Control Arm | 2 |
| Study Arm | 3 |
The Number of Patients Experiencing Restlessness
Yes/No (NCT02657031)
Timeframe: 0-60 minutes
| Intervention | participants (Number) |
|---|---|
| Control Arm | 3 |
| Study Arm | 3 |
Efficacy of Sedation
"Efficacy is defined as:~The patient does not have unpleasant recall of the procedure.~The patient did not experience sedation-related adverse events resulting in abandonment of the procedure or a permanent complication or an unplanned admission to the hospital or prolonged emergency department (ED) observation~The patient did not actively resist or require physical restraint for completion of the procedure. The need for minimal redirection of movements should not be considered as active resistance or physical restraint.~The procedure was successful" (NCT01387139)
Timeframe: After procedure is completed, on average less than 1 hour
| Intervention | participants (Number) |
|---|---|
| Ketamine Alone | 97 |
| Ketamine Co-Administered With Propofol | 81 |
Nurse Satisfaction
Measured on a 10-point scale (1= least satisfied, 10= most satisfied) (NCT01387139)
Timeframe: After procedure is completed, on average less than 1 hour
| Intervention | units on a scale (Median) |
|---|---|
| Ketamine Alone | 10 |
| Ketamine Co-Administered With Propofol | 8 |
Parent Satisfaction
Measured on a 10-point scale (1= least satisfied, 10= most satisfied) (NCT01387139)
Timeframe: After procedure is completed, on average less than 1 hour
| Intervention | units on a scale (1-10) (Median) |
|---|---|
| Ketamine Alone | 10 |
| Ketamine Co-Administered With Propofol | 10 |
Physician Performing Procedure Satisfaction
Measured on a 10-point scale (1= least satisfied, 10= most satisfied) (NCT01387139)
Timeframe: After procedure is completed, on average less than 1 hour
| Intervention | units on a scale (Median) |
|---|---|
| Ketamine Alone | 9 |
| Ketamine Co-Administered With Propofol | 8 |
Recovery Time
Time until the patient has a Vancouver Sedation Recovery Scale Score of 18 or greater. (NCT01387139)
Timeframe: Once Vancouver Sedation Recovery Scale Score reaches 18 or greater, on average less than 1 hour
| Intervention | minutes (Median) |
|---|---|
| Ketamine Alone | 44 |
| Ketamine Co-Administered With Propofol | 43.5 |
Frequency of Adverse Events
We will record all adverse events during the sedation, and then perform a follow-up call to determine if any additional adverse events occured after discharge. (NCT01387139)
Timeframe: From enrollment through completion of follow-up, up to 7 days
| Intervention | participants (Number) | |||
|---|---|---|---|---|
| Respiratory depression | Cardiovascular event | vomiting/retching | Unpleasant recovery reaction | |
| Ketamine Alone | 12 | 1 | 21 | 4 |
| Ketamine Co-Administered With Propofol | 15 | 0 | 18 | 2 |
Cumulative Hydrocodone/Acetaminophen for Supplemental Analgesia to Treat Breakthrough Pain
Cumulative hydrocodone/acetaminophen for supplemental analgesia to treat breakthrough pain for 72 hours following cesarean delivery (NCT00486902)
Timeframe: 72 hours
| Intervention | tablets (Median) |
|---|---|
| Ketamine | 10 |
| Placebo | 9 |
Disturbing Dreams
Number of subject reporting disturbing dreams at 72 hours post cesarean delivery (NCT00486902)
Timeframe: 72 hours
| Intervention | participants (Number) |
|---|---|
| Ketamine | 0 |
| Placebo | 0 |
Number of Subjects Requiring Supplemental Analgesia in the First 24 Hours Following Cesarean Delivery
Request for oral hydrocodone/acetaminophen for pain not controlled by around the clock non-steroidal antiflammatory drugs in the first 24 hours following cesarean delivery. (NCT00486902)
Timeframe: 24 hours
| Intervention | participants (Number) |
|---|---|
| Ketamine | 64 |
| Placebo | 66 |
Pain Score (0-10) at 2 Weeks Following Cesarean Delivery
Numeric rating for pain score (0 to 10) reported at 2 weeks following cesarean delivery. Zero is no pain and 10 is worst pain imaginable. (NCT00486902)
Timeframe: 2 weeks
| Intervention | Scores on a scale (Median) |
|---|---|
| Ketamine | 2 |
| Placebo | 2.6 |
Postoperative Nausea
Number of subjects reporting nausea in first 24 hours following cesarean delivery (NCT00486902)
Timeframe: 24 hours
| Intervention | participants (Number) |
|---|---|
| Ketamine | 27 |
| Placebo | 30 |
Postoperative Vomiting
Number of subjects that vomited in the first 24 hours following cesarean delivery (NCT00486902)
Timeframe: 24 hours
| Intervention | participants (Number) |
|---|---|
| Ketamine | 13 |
| Placebo | 13 |
Postperative Pruritus
Number of subjects with pruritus in the first 24 hours following cesarean delivery (NCT00486902)
Timeframe: 24 hours
| Intervention | participants (Number) |
|---|---|
| Ketamine | 12 |
| Placebo | 19 |
Verbal Pain Scores (0 to 10) at First Analgesia Request
Numeric rating of pain scores (NRS) scale (0 to 10) at time of supplemental analgesia request. Zero is no pain and 10 is worst pain imaginable. (NCT00486902)
Timeframe: 24 hours
| Intervention | Scores on a scale (Median) |
|---|---|
| Ketamine | 3 |
| Placebo | 4 |
NRS Pain = Numeric Rating Scale (0-10)
The numeric rating scale (NRS) is used to measure the intensity of pain. The value 0 means no pain and the value 10 represents maximal pain. a higher intensity of pain is associated with a worse outcome. (NCT00354029)
Timeframe: 24 hours
| Intervention | Units on a scale (Mean) |
|---|---|
| S (+) Ketamine | 1.6 |
| Placebo | 1.5 |
Change in Level of Pain Control as Reported on the NRS-11
"Patient-reported pain scores on numerical rating scale (NRS) -11 pain scale (where 0 indicates no pain at all, 10 indicates the most severe pain). Initial group were patients enrolled and randomized in to the study, assessments were taken at the time of enrollment/randomization in to the study (up to 20 min prior to T=0). T = 0 min assessments were conducted at the time of medication administration (study allowed for an up to 20-minute delay in receiving study drug in order to retrieve study drug from secure storage, nursing documentation and patient verification prior to administration)." (NCT02489630)
Timeframe: 20 min pre-medication administration, 0 min, 30 min, 60 min, 90 min, 120 min post medication administration
| Intervention | Units on a scale (1-10) (Mean) | |||||
|---|---|---|---|---|---|---|
| Initial | T = 0 min | T = 30 min | T = 60 min | T = 90 min | T = 120 min | |
| Ketamine | 9.38 | 7.51 | 5.25 | 5.31 | 4.51 | 4.24 |
| Placebo | 9.44 | 8.10 | 2.27 | 6.18 | 6.21 | 5.68 |
Change in Patient Satisfaction With Pain Control on a 1-4 Likert Scale
Patient-reported score regarding satisfaction with pain control, reported on a 4-point Likert scale (1-4, where 1 is the lowest satisfaction score possible and 4 is the highest satisfaction score possible). No data is reported for T = 0 min, as that assessment was conducted concurrently with initial medication dosing (since patients were at that point receiving their first pain control efforts, they could not yet assess their satisfaction with those efforts). (NCT02489630)
Timeframe: 0 min, 30 min, 60 min, 90 min, 120 min post medication administration
| Intervention | Units on a scale (1-4) (Mean) | |||
|---|---|---|---|---|
| T = 30 min | T = 60 min | T = 90 min | T = 120 min | |
| Ketamine | 2.09 | 2.38 | 2.54 | 2.66 |
| Placebo | 2.27 | 2.33 | 2.38 | 2.52 |
Difference in Opiate Dosage Between Study Arms in Morphine Equivalents
"Average difference in opiate dosage between study arms, calculated in morphine equivalents. Initial indicates at first dose of opioid administration, up to 20 mins prior to study drug administration, and from 0 min to 120 min after study drug administration." (NCT02489630)
Timeframe: 20 mins pre-medication administration, 0 min, 30 min, 60 min, 90 min, 120 min post medication administration
| Intervention | Milligrams of Morphine Equivalent (Mean) | |
|---|---|---|
| Initial Narcotic Dosage | Total Narcotic Dosage | |
| Ketamine | 5.41 | 9.95 |
| Placebo | 5.83 | 12.81 |
Number of Patients With Pain Associated With Injection of Propofol.
"Ten seconds following injection of propofol, subjects were asked Are you having pain at your IV site? Any behavioral signs were noted. Injection pain was assessed using the following four point scale: 0 = no pain; 1 = mild pain (pain reported only in response to questioning and without behavioral signs); 2 = moderate pain (pain reported in response to questioning and accompanied by a behavioral sign, or pain reported spontaneously without questioning); and 3 = severe pain (strong vocal response or response accompanied by facial grimacing, arm withdrawal, or tears)." (NCT01342510)
Timeframe: < 1 minute.
| Intervention | participants reporting pain (Number) |
|---|---|
| Lidocaine | 11 |
| Magnesium | 25 |
| Lidocaine/Magnesium | 15 |
| Control | 18 |
Percentage of Participants Reporting Pain With Injection of Propofol
Following injection of the study drug, 50 mg of propofol will be injected. Ten seconds after propofol, subjects will be asked a standard question about pain. Behavioral signs will be noted. Pain will be assessed using a four point scale: 0=no pain, 1=mild pain (pain reported only in response to questioning and without behavioral signs), 2=moderate pain (pain reported in response to questioning and a behavioral sign, or pain reported without questioning), 3=severe pain (strong vocal response or behavioral response). (NCT01342510)
Timeframe: Approximately 10 seconds following administration of propofol.
| Intervention | percentage of patients reporting pain (Number) |
|---|---|
| Lidocaine | 29 |
| Magnesium | 57 |
| Lidocaine/Magnesium | 41 |
| Control | 46 |
Dehydronorketamine Concentration in Breast Milk at 24 and 30 Hours After an IM Administration of 1mg/kg Ketamine
"Quantitative analysis of the concentration of ketamine and its metabolites in breast milk (collected by pumping breast milk into containers at 24 and 30 hours post ketamine IM administration) was performed at the Clinical Medicine and Toxicology Laboratory at UCSF School of Medicine. Sample aliquots were frozen in our conventional freezer at the clinic where the sessions took place, labelled with a HIPAA compliant code which blinded the lab to all patient data.~The limits of sensitivity for the quantification of each substance were:~Ketamine: 0.25 ng Norketamine: 0.25 ng Dehydronorketamine: 0.1 ng Hydroxynorketamine: 0.25 ng" (NCT04285684)
Timeframe: 24 and 30 hour collections
| Intervention | ng/mL (Mean) | |
|---|---|---|
| 24 Hours | 30 Hours | |
| Ketamine During Lactation | .3 | .3 |
Dehydronorketamine Concentration in Breast Milk, up to 12 Hours at 3 Hour Intervals, Following an IM Administration of .5mg/kg Ketamine
"Quantitative analysis of the concentration of ketamine and its metabolites in breast milk (collected by pumping breast milk into containers at 3, 6, 9, and 12 hours post ketamine IM administration) was performed at the Clinical Medicine and Toxicology Laboratory at UCSF School of Medicine. Sample aliquots were frozen in our conventional freezer at the clinic where the sessions took place, labelled with a HIPAA compliant code which blinded the lab to all patient data.~The limits of sensitivity for the quantification of each substance were:~Ketamine: 0.25 ng Norketamine: 0.25 ng Dehydronorketamine: 0.1 ng Hydroxynorketamine: 0.25 ng" (NCT04285684)
Timeframe: 3, 6, 9, and 12 hour collections
| Intervention | ng/mL (Mean) | |||
|---|---|---|---|---|
| 3 Hours | 6 Hours | 9 Hours | 12 Hours | |
| Ketamine During Lactation | .56 | .55 | .45 | .21 |
Dehydronorketamine Concentration in Breast Milk, up to 12 Hours at 3 Hour Intervals, Following an IM Administration of 1mg/kg Ketamine
"Quantitative analysis of the concentration of ketamine and its metabolites in breast milk (collected by pumping breast milk into containers at 3, 6, 9, and 12 hours post ketamine IM administration) was performed at the Clinical Medicine and Toxicology Laboratory at UCSF School of Medicine. Sample aliquots were frozen in our conventional freezer at the clinic where the sessions took place, labelled with a HIPAA compliant code which blinded the lab to all patient data.~The limits of sensitivity for the quantification of each substance were:~Ketamine: 0.25 ng Norketamine: 0.25 ng Dehydronorketamine: 0.1 ng Hydroxynorketamine: 0.25 ng" (NCT04285684)
Timeframe: 3, 6, 9, and 12 hour collections
| Intervention | ng/mL (Mean) | |||
|---|---|---|---|---|
| 3 Hours | 6 Hours | 9 Hours | 12 Hours | |
| Ketamine During Lactation | 2.0 | 1.9 | 1.4 | 1.1 |
Hydroxynorketamine Concentration in Breast Milk at 24 and 30 Hours After an IM Administration of 1mg/kg Ketamine
"Quantitative analysis of the concentration of ketamine and its metabolites in breast milk (collected by pumping breast milk into containers at 24 and 30 hours post ketamine IM administration) was performed at the Clinical Medicine and Toxicology Laboratory at UCSF School of Medicine. Sample aliquots were frozen in our conventional freezer at the clinic where the sessions took place, labelled with a HIPAA compliant code which blinded the lab to all patient data.~The limits of sensitivity for the quantification of each substance were:~Ketamine: 0.25 ng Norketamine: 0.25 ng Dehydronorketamine: 0.1 ng Hydroxynorketamine: 0.25 ng" (NCT04285684)
Timeframe: 24 and 30 hour collections
| Intervention | ng/mL (Mean) | |
|---|---|---|
| 24 Hours | 30 Hours | |
| Ketamine During Lactation | 30.5 | 13.9 |
Hydroxynorketamine Concentration in Breast Milk, up to 12 Hours at 3 Hour Intervals, Following an IM Administration of .5mg/kg Ketamine
"Quantitative analysis of the concentration of ketamine and its metabolites in breast milk (collected by pumping breast milk into containers at 3, 6, 9, and 12 hours post ketamine IM administration) was performed at the Clinical Medicine and Toxicology Laboratory at UCSF School of Medicine. Sample aliquots were frozen in our conventional freezer at the clinic where the sessions took place, labelled with a HIPAA compliant code which blinded the lab to all patient data.~The limits of sensitivity for the quantification of each substance were:~Ketamine: 0.25 ng Norketamine: 0.25 ng Dehydronorketamine: 0.1 ng Hydroxynorketamine: 0.25 ng" (NCT04285684)
Timeframe: 3, 6, 9, and 12 hour collections
| Intervention | ng/mL (Mean) | |||
|---|---|---|---|---|
| 3 Hours | 6 Hours | 9 Hours | 12 Hours | |
| Ketamine During Lactation | 29.9 | 28.3 | 25.6 | 17.5 |
Hydroxynorketamine Concentration in Breast Milk, up to 12 Hours at 3 Hour Intervals, Following an IM Administration of 1mg/kg Ketamine
"Quantitative analysis of the concentration of ketamine and its metabolites in breast milk (collected by pumping breast milk into containers at 3, 6, 9, and 12 hours post ketamine IM administration) was performed at the Clinical Medicine and Toxicology Laboratory at UCSF School of Medicine. Sample aliquots were frozen in our conventional freezer at the clinic where the sessions took place, labelled with a HIPAA compliant code which blinded the lab to all patient data.~The limits of sensitivity for the quantification of each substance were:~Ketamine: 0.25 ng Norketamine: 0.25 ng Dehydronorketamine: 0.1 ng Hydroxynorketamine: 0.25 ng" (NCT04285684)
Timeframe: 3, 6, 9, and 12 hour collections
| Intervention | ng/mL (Mean) | |||
|---|---|---|---|---|
| 3 Hours | 6 Hours | 9 Hours | 12 Hours | |
| Ketamine During Lactation | 64.1 | 66.9 | 54.6 | 41.6 |
Ketamine Concentration in Breast Milk at 24 and 30 Hours After an IM Administration of 1mg/kg Ketamine
"Quantitative analysis of the concentration of ketamine and its metabolites in breast milk (collected by pumping breast milk into containers at 24 and 30 hours post ketamine IM administration) was performed at the Clinical Medicine and Toxicology Laboratory at UCSF School of Medicine. Sample aliquots were frozen in our conventional freezer at the clinic where the sessions took place, labelled with a HIPAA compliant code which blinded the lab to all patient data.~The limits of sensitivity for the quantification of each substance were:~Ketamine: 0.25 ng Norketamine: 0.25 ng Dehydronorketamine: 0.1 ng Hydroxynorketamine: 0.25 ng" (NCT04285684)
Timeframe: 24 and 30 hour collections
| Intervention | ng/mL (Mean) | |
|---|---|---|
| 24 Hours | 30 Hours | |
| Ketamine During Lactation | 4.9 | 6.4 |
Ketamine Concentration in Breast Milk, up to 12 Hours at 3 Hour Intervals, Following an IM Administration of .5mg/kg Ketamine
"Quantitative analysis of the concentration of ketamine and its metabolites in breast milk (collected by pumping breast milk into containers at 3, 6, 9, and 12 hours post ketamine IM administration) was performed at the Clinical Medicine and Toxicology Laboratory at UCSF School of Medicine. Sample aliquots were frozen in our conventional freezer at the clinic where the sessions took place, labelled with a HIPAA compliant code which blinded the lab to all patient data.~The limits of sensitivity for the quantification of each substance were:~Ketamine: 0.25 ng Norketamine: 0.25 ng Dehydronorketamine: 0.1 ng Hydroxynorketamine: 0.25 ng" (NCT04285684)
Timeframe: 3, 6, 9, and 12 hour collections
| Intervention | ng/mL (Mean) | |||
|---|---|---|---|---|
| 3 Hours | 6 Hours | 9 Hours | 12 Hours | |
| Ketamine During Lactation | 51.2 | 22.6 | 10.6 | 4.5 |
Ketamine Concentration in Breast Milk, up to 12 Hours at 3 Hour Intervals, Following an IM Administration of 1mg/kg Ketamine
"Quantitative analysis of the concentration of ketamine and its metabolites in breast milk (collected by pumping breast milk into containers at 3, 6, 9, and 12 hours post ketamine IM administration) was performed at the Clinical Medicine and Toxicology Laboratory at UCSF School of Medicine. Sample aliquots were frozen in our conventional freezer at the clinic where the sessions took place, labelled with a HIPAA compliant code which blinded the lab to all patient data.~The limits of sensitivity for the quantification of each substance were:~Ketamine: 0.25 ng Norketamine: 0.25 ng Dehydronorketamine: 0.1 ng Hydroxynorketamine: 0.25 ng" (NCT04285684)
Timeframe: 3, 6, 9, and 12 hour collections
| Intervention | ng/mL (Mean) | |||
|---|---|---|---|---|
| 3 Hours | 6 Hours | 9 Hours | 12 Hours | |
| Ketamine During Lactation | 125.0 | 48.2 | 21.6 | 18.5 |
Norketamine Concentration in Breast Milk at 24 and 30 Hours After an IM Administration of 1mg/kg Ketamine
"Quantitative analysis of the concentration of ketamine and its metabolites in breast milk (collected by pumping breast milk into containers at 24 and 30 hours post ketamine IM administration) was performed at the Clinical Medicine and Toxicology Laboratory at UCSF School of Medicine. Sample aliquots were frozen in our conventional freezer at the clinic where the sessions took place, labelled with a HIPAA compliant code which blinded the lab to all patient data.~The limits of sensitivity for the quantification of each substance were:~Ketamine: 0.25 ng Norketamine: 0.25 ng Dehydronorketamine: 0.1 ng Hydroxynorketamine: 0.25 ng" (NCT04285684)
Timeframe: 24 and 30 hour collections
| Intervention | ng/mL (Mean) | |
|---|---|---|
| 24 Hours | 30 Hours | |
| Ketamine During Lactation | 10.3 | 9.9 |
Norketamine Concentration in Breast Milk, up to 12 Hours at 3 Hour Intervals, Following an IM Administration of .5mg/kg Ketamine
"Quantitative analysis of the concentration of ketamine and its metabolites in breast milk (collected by pumping breast milk into containers at 3, 6, 9, and 12 hours post ketamine IM administration) was performed at the Clinical Medicine and Toxicology Laboratory at UCSF School of Medicine. Sample aliquots were frozen in our conventional freezer at the clinic where the sessions took place, labelled with a HIPAA compliant code which blinded the lab to all patient data.~The limits of sensitivity for the quantification of each substance were:~Ketamine: 0.25 ng Norketamine: 0.25 ng Dehydronorketamine: 0.1 ng Hydroxynorketamine: 0.25 ng" (NCT04285684)
Timeframe: 3, 6, 9, and 12 hour collections
| Intervention | ng/mL (Mean) | |||
|---|---|---|---|---|
| 3 Hours | 6 Hours | 9 Hours | 12 Hours | |
| Ketamine During Lactation | 42.6 | 28.6 | 18.8 | 8.7 |
Norketamine Concentration in Breast Milk, up to 12 Hours at 3 Hour Intervals, Following an IM Administration of 1mg/kg Ketamine
"Quantitative analysis of the concentration of ketamine and its metabolites in breast milk (collected by pumping breast milk into containers at 3, 6, 9, and 12 hours post ketamine IM administration) was performed at the Clinical Medicine and Toxicology Laboratory at UCSF School of Medicine. Sample aliquots were frozen in our conventional freezer at the clinic where the sessions took place, labelled with a HIPAA compliant code which blinded the lab to all patient data.~The limits of sensitivity for the quantification of each substance were:~Ketamine: 0.25 ng Norketamine: 0.25 ng Dehydronorketamine: 0.1 ng Hydroxynorketamine: 0.25 ng" (NCT04285684)
Timeframe: 3, 6, 9, and 12 hour collections
| Intervention | ng/mL (Mean) | |||
|---|---|---|---|---|
| 3 Hours | 6 Hours | 9 Hours | 12 Hours | |
| Ketamine During Lactation | 92.7 | 62.4 | 37.3 | 32.3 |
Montgomery-Asberg Depression Rating Scale (MADRS) Total Score
The Montgomery-Asberg Depression Rating Scale (MADRS) is a 10-item scale that measures the severity of depression, with a higher score indicating a higher level of depression. The range of scores is 0 to 60. (NCT01179009)
Timeframe: 8 weeks
| Intervention | Scores on a scale (Mean) |
|---|---|
| Ketamine 100-hour Infusion | -9.0 |
| Ketamine 40-minute Infusion | -6.4 |
Reviews
119 reviews available for ketamine and Ache
| Article | Year |
|---|---|
Low-dose Ketamine Infusion for Pediatric Hematology/Oncology Patients: Case Series and Literature Review.
Topics: Adolescent; Adult; Anemia, Sickle Cell; Child; Female; Humans; Ketamine; Male; Pain | 2022 |
Influence of ketamine versus fentanyl on pain relief for pediatric orthopedic emergencies: A meta-analysis of randomized controlled studies.
Topics: Adolescent; Child; Child, Preschool; Drug Administration Routes; Emergencies; Female; Fentanyl; Huma | 2021 |
Pharmacological treatment in adult patients with CRPS-I: a systematic review and meta-analysis of randomized controlled trials.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2 Inhibitors; Diphosphonates; Humans; | 2022 |
Global Trends and Hotspots in Esketamine Research: A Bibliometric Analysis of Past and Estimation of Future Trends.
Topics: Bibliometrics; Databases, Factual; Humans; Ketamine; Pain; United States | 2022 |
Analgesia and Sedation for Tactical Combat Casualty Care: TCCC Proposed Change 21-02.
Topics: Analgesia; Humans; Ketamine; Military Medicine; Pain; Pain Management | 2022 |
Pharmacologic therapies of pain in patients with spinal cord injury: a systematic review.
Topics: Amitriptyline; Anticonvulsants; Gabapentin; Humans; Ketamine; Pain; Pregabalin; Spinal Cord Injuries | 2022 |
Patterns of Palliation: A Review of Casualties That Received Pain Management Before Reaching Role 2 in Afghanistan.
Topics: Adult; Afghan Campaign 2001-; Afghanistan; Emergency Medical Services; Fentanyl; Humans; Ketamine; M | 2023 |
Management of Pain and Agitation in Trauma.
Topics: Analgesics, Opioid; Humans; Ketamine; Multiple Trauma; Pain; Propofol | 2023 |
Management of Pain and Agitation in Trauma.
Topics: Analgesics, Opioid; Humans; Ketamine; Multiple Trauma; Pain; Propofol | 2023 |
Management of Pain and Agitation in Trauma.
Topics: Analgesics, Opioid; Humans; Ketamine; Multiple Trauma; Pain; Propofol | 2023 |
Management of Pain and Agitation in Trauma.
Topics: Analgesics, Opioid; Humans; Ketamine; Multiple Trauma; Pain; Propofol | 2023 |
Management of Pain and Agitation in Trauma.
Topics: Analgesics, Opioid; Humans; Ketamine; Multiple Trauma; Pain; Propofol | 2023 |
Management of Pain and Agitation in Trauma.
Topics: Analgesics, Opioid; Humans; Ketamine; Multiple Trauma; Pain; Propofol | 2023 |
Management of Pain and Agitation in Trauma.
Topics: Analgesics, Opioid; Humans; Ketamine; Multiple Trauma; Pain; Propofol | 2023 |
Management of Pain and Agitation in Trauma.
Topics: Analgesics, Opioid; Humans; Ketamine; Multiple Trauma; Pain; Propofol | 2023 |
Management of Pain and Agitation in Trauma.
Topics: Analgesics, Opioid; Humans; Ketamine; Multiple Trauma; Pain; Propofol | 2023 |
Systematic review and meta-analysis of ketamine-associated uropathy.
Topics: Cystitis; Humans; Ketamine; Pain; Urinary Bladder; Urologic Diseases | 2022 |
Systematic review and meta-analysis of ketamine-associated uropathy.
Topics: Cystitis; Humans; Ketamine; Pain; Urinary Bladder; Urologic Diseases | 2022 |
Systematic review and meta-analysis of ketamine-associated uropathy.
Topics: Cystitis; Humans; Ketamine; Pain; Urinary Bladder; Urologic Diseases | 2022 |
Systematic review and meta-analysis of ketamine-associated uropathy.
Topics: Cystitis; Humans; Ketamine; Pain; Urinary Bladder; Urologic Diseases | 2022 |
Efficacy and safety of perioperative application of ketamine on postoperative depression: A meta-analysis of randomized controlled studies.
Topics: Antidepressive Agents; Depression; Depressive Disorder; Humans; Ketamine; Pain; Pain, Postoperative; | 2023 |
Non-surgical management and analgesia strategies for older adults with multiple rib fractures: A systematic review, meta-analysis, and joint practice management guideline from the Eastern Association for the Surgery of Trauma and the Chest Wall Injury Soc
Topics: Aged; Analgesia, Epidural; Humans; Ketamine; Length of Stay; Neck Injuries; Pain; Pneumonia; Rib Fra | 2023 |
A Comparison of Prehospital Pediatric Analgesic Use of Ketamine and Opioids.
Topics: Analgesics; Analgesics, Opioid; Child; Emergency Medical Services; Humans; Ketamine; Pain; Retrospec | 2023 |
Non-opioid analgesics for procedural pain in neonates.
Topics: Aged; Analgesics; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Apnea; Body Wei | 2023 |
Low-dose ketamine or opioids combined with propofol for procedural sedation in the emergency department: a systematic review.
Topics: Analgesics, Opioid; Conscious Sedation; Emergency Service, Hospital; Fentanyl; Humans; Hypnotics and | 2023 |
Analysis of the efficacy of subclinical doses of esketamine in combination with propofol in non-intubated general anesthesia procedures - a systematic review and meta-analysis.
Topics: Anesthesia, General; Drug-Related Side Effects and Adverse Reactions; Humans; Ketamine; Pain; Propof | 2023 |
Intranasal analgesia for acute moderate to severe pain in children - a systematic review and meta-analysis.
Topics: Analgesia; Child; Fentanyl; Humans; Ketamine; Ketorolac; Pain | 2023 |
Oral ketamine may offer a solution to the ketamine conundrum.
Topics: Antidepressive Agents; Biological Availability; Humans; Ketamine; Pain | 2023 |
Use of ketamine for prehospital pain control on the battlefield: A systematic review.
Topics: Administration, Intravenous; Afghan Campaign 2001-; Analgesics; Blood Pressure; Dose-Response Relati | 2020 |
Suicide Has Many Faces, So Does Ketamine: a Narrative Review on Ketamine's Antisuicidal Actions.
Topics: Antidepressive Agents; Humans; Inflammation; Ketamine; Neuronal Plasticity; Pain; Reward; Suicidal I | 2019 |
Meeting the Challenge of Analgesia in a Pregnant Woman With Burn Injury Using Subanesthetic Ketamine: A Case Report and Literature Review.
Topics: Adult; Analgesics; Burns; Female; Humans; Infusions, Intravenous; Ketamine; Pain; Pregnancy; Pregnan | 2020 |
Ketamine as a Prehospital Analgesic: A Systematic Review.
Topics: Analgesics; Emergency Medical Services; Humans; Ketamine; Pain; Pain Management; Pain Measurement; W | 2020 |
Anaesthetic management of subcutaneous abscesses: current status.
Topics: Abscess; Administration, Topical; Anesthesia; Anesthetics, Dissociative; Anesthetics, Local; Drainag | 2020 |
Ketamine: a versatile tool for anesthesia and analgesia.
Topics: Analgesia; Analgesics; Anesthesia; Anesthetics, Dissociative; Burns; Depression; Humans; Ketamine; P | 2020 |
Ketamine: a versatile tool for anesthesia and analgesia.
Topics: Analgesia; Analgesics; Anesthesia; Anesthetics, Dissociative; Burns; Depression; Humans; Ketamine; P | 2020 |
Ketamine: a versatile tool for anesthesia and analgesia.
Topics: Analgesia; Analgesics; Anesthesia; Anesthetics, Dissociative; Burns; Depression; Humans; Ketamine; P | 2020 |
Ketamine: a versatile tool for anesthesia and analgesia.
Topics: Analgesia; Analgesics; Anesthesia; Anesthetics, Dissociative; Burns; Depression; Humans; Ketamine; P | 2020 |
Ketamine: a versatile tool for anesthesia and analgesia.
Topics: Analgesia; Analgesics; Anesthesia; Anesthetics, Dissociative; Burns; Depression; Humans; Ketamine; P | 2020 |
Ketamine: a versatile tool for anesthesia and analgesia.
Topics: Analgesia; Analgesics; Anesthesia; Anesthetics, Dissociative; Burns; Depression; Humans; Ketamine; P | 2020 |
Ketamine: a versatile tool for anesthesia and analgesia.
Topics: Analgesia; Analgesics; Anesthesia; Anesthetics, Dissociative; Burns; Depression; Humans; Ketamine; P | 2020 |
Ketamine: a versatile tool for anesthesia and analgesia.
Topics: Analgesia; Analgesics; Anesthesia; Anesthetics, Dissociative; Burns; Depression; Humans; Ketamine; P | 2020 |
Ketamine: a versatile tool for anesthesia and analgesia.
Topics: Analgesia; Analgesics; Anesthesia; Anesthetics, Dissociative; Burns; Depression; Humans; Ketamine; P | 2020 |
A review of the clinical applications of ketamine in pediatric oncology.
Topics: Analgesics; Child; Humans; Ketamine; Neoplasms; Pain; Prognosis | 2021 |
Ketamine-polymer based drug delivery system for prolonged analgesia: recent advances, challenges and future prospects.
Topics: Analgesia; Delayed-Action Preparations; Humans; Ketamine; Pain; Polymers; Quality of Life | 2021 |
A systematic review of ketamine for the management of vaso-occlusive pain in sickle cell disease.
Topics: Anemia, Sickle Cell; Humans; Ketamine; Pain; Pain Management; Pain Measurement | 2021 |
Ketamine in the Past, Present, and Future: Mechanisms, Metabolites, and Toxicity.
Topics: Animals; Forecasting; Humans; Ketamine; Pain | 2021 |
Ketamine for Pain Management-Side Effects & Potential Adverse Events.
Topics: Analgesics; Drug-Related Side Effects and Adverse Reactions; Humans; Ketamine; Pain; Pain Management | 2017 |
Principles of Burn Pain Management.
Topics: Analgesics; Analgesics, Opioid; Anesthetics; Burns; Exercise Therapy; Humans; Intraoperative Care; K | 2017 |
The Expanding Role of Ketamine in the Emergency Department.
Topics: Analgesics; Blood-Brain Barrier; Emergency Service, Hospital; Humans; Ketamine; Pain | 2018 |
Emerging Trends in Pain Medication Management: Back to the Future: A Focus on Ketamine.
Topics: Analgesics; Chronic Pain; Humans; Ketamine; Pain; Pain Management | 2018 |
An Update on the Basic and Clinical Science of Ketamine Analgesia.
Topics: Analgesics; Animals; Humans; Ketamine; Pain | 2018 |
An Update on the Basic and Clinical Science of Ketamine Analgesia.
Topics: Analgesics; Animals; Humans; Ketamine; Pain | 2018 |
An Update on the Basic and Clinical Science of Ketamine Analgesia.
Topics: Analgesics; Animals; Humans; Ketamine; Pain | 2018 |
An Update on the Basic and Clinical Science of Ketamine Analgesia.
Topics: Analgesics; Animals; Humans; Ketamine; Pain | 2018 |
Scientific Issues Relevant to Improving the Diagnosis, Risk Assessment, and Treatment of Major Depression.
Topics: Antidepressive Agents; Anxiety; Biomedical Research; Depressive Disorder, Major; Diagnostic and Stat | 2019 |
The Efficacy of Ketamine in the Palliative Care Setting: A Comprehensive Review of the Literature.
Topics: Administration, Intranasal; Administration, Intravenous; Adult; Aged; Aged, 80 and over; Antidepress | 2019 |
Ketamine: use in anesthesia.
Topics: Anesthesia; Anesthetics, Dissociative; Animals; Drug Administration Routes; Emergency Service, Hospi | 2013 |
Ketamine: use in anesthesia.
Topics: Anesthesia; Anesthetics, Dissociative; Animals; Drug Administration Routes; Emergency Service, Hospi | 2013 |
Ketamine: use in anesthesia.
Topics: Anesthesia; Anesthetics, Dissociative; Animals; Drug Administration Routes; Emergency Service, Hospi | 2013 |
Ketamine: use in anesthesia.
Topics: Anesthesia; Anesthetics, Dissociative; Animals; Drug Administration Routes; Emergency Service, Hospi | 2013 |
Ketamine: use in anesthesia.
Topics: Anesthesia; Anesthetics, Dissociative; Animals; Drug Administration Routes; Emergency Service, Hospi | 2013 |
Ketamine: use in anesthesia.
Topics: Anesthesia; Anesthetics, Dissociative; Animals; Drug Administration Routes; Emergency Service, Hospi | 2013 |
Ketamine: use in anesthesia.
Topics: Anesthesia; Anesthetics, Dissociative; Animals; Drug Administration Routes; Emergency Service, Hospi | 2013 |
Ketamine: use in anesthesia.
Topics: Anesthesia; Anesthetics, Dissociative; Animals; Drug Administration Routes; Emergency Service, Hospi | 2013 |
Ketamine: use in anesthesia.
Topics: Anesthesia; Anesthetics, Dissociative; Animals; Drug Administration Routes; Emergency Service, Hospi | 2013 |
Low-dose ketamine as a potential adjuvant therapy for painful vaso-occlusive crises in sickle cell disease.
Topics: Anemia, Sickle Cell; Anesthetics, Dissociative; Arterial Occlusive Diseases; Drug Tolerance; Excitat | 2013 |
Low-dose ketamine as a potential adjuvant therapy for painful vaso-occlusive crises in sickle cell disease.
Topics: Anemia, Sickle Cell; Anesthetics, Dissociative; Arterial Occlusive Diseases; Drug Tolerance; Excitat | 2013 |
Low-dose ketamine as a potential adjuvant therapy for painful vaso-occlusive crises in sickle cell disease.
Topics: Anemia, Sickle Cell; Anesthetics, Dissociative; Arterial Occlusive Diseases; Drug Tolerance; Excitat | 2013 |
Low-dose ketamine as a potential adjuvant therapy for painful vaso-occlusive crises in sickle cell disease.
Topics: Anemia, Sickle Cell; Anesthetics, Dissociative; Arterial Occlusive Diseases; Drug Tolerance; Excitat | 2013 |
Low-dose ketamine as a potential adjuvant therapy for painful vaso-occlusive crises in sickle cell disease.
Topics: Anemia, Sickle Cell; Anesthetics, Dissociative; Arterial Occlusive Diseases; Drug Tolerance; Excitat | 2013 |
Low-dose ketamine as a potential adjuvant therapy for painful vaso-occlusive crises in sickle cell disease.
Topics: Anemia, Sickle Cell; Anesthetics, Dissociative; Arterial Occlusive Diseases; Drug Tolerance; Excitat | 2013 |
Low-dose ketamine as a potential adjuvant therapy for painful vaso-occlusive crises in sickle cell disease.
Topics: Anemia, Sickle Cell; Anesthetics, Dissociative; Arterial Occlusive Diseases; Drug Tolerance; Excitat | 2013 |
Low-dose ketamine as a potential adjuvant therapy for painful vaso-occlusive crises in sickle cell disease.
Topics: Anemia, Sickle Cell; Anesthetics, Dissociative; Arterial Occlusive Diseases; Drug Tolerance; Excitat | 2013 |
Low-dose ketamine as a potential adjuvant therapy for painful vaso-occlusive crises in sickle cell disease.
Topics: Anemia, Sickle Cell; Anesthetics, Dissociative; Arterial Occlusive Diseases; Drug Tolerance; Excitat | 2013 |
Low-dose ketamine as a potential adjuvant therapy for painful vaso-occlusive crises in sickle cell disease.
Topics: Anemia, Sickle Cell; Anesthetics, Dissociative; Arterial Occlusive Diseases; Drug Tolerance; Excitat | 2013 |
Low-dose ketamine as a potential adjuvant therapy for painful vaso-occlusive crises in sickle cell disease.
Topics: Anemia, Sickle Cell; Anesthetics, Dissociative; Arterial Occlusive Diseases; Drug Tolerance; Excitat | 2013 |
Low-dose ketamine as a potential adjuvant therapy for painful vaso-occlusive crises in sickle cell disease.
Topics: Anemia, Sickle Cell; Anesthetics, Dissociative; Arterial Occlusive Diseases; Drug Tolerance; Excitat | 2013 |
Low-dose ketamine as a potential adjuvant therapy for painful vaso-occlusive crises in sickle cell disease.
Topics: Anemia, Sickle Cell; Anesthetics, Dissociative; Arterial Occlusive Diseases; Drug Tolerance; Excitat | 2013 |
Low-dose ketamine as a potential adjuvant therapy for painful vaso-occlusive crises in sickle cell disease.
Topics: Anemia, Sickle Cell; Anesthetics, Dissociative; Arterial Occlusive Diseases; Drug Tolerance; Excitat | 2013 |
Low-dose ketamine as a potential adjuvant therapy for painful vaso-occlusive crises in sickle cell disease.
Topics: Anemia, Sickle Cell; Anesthetics, Dissociative; Arterial Occlusive Diseases; Drug Tolerance; Excitat | 2013 |
Low-dose ketamine as a potential adjuvant therapy for painful vaso-occlusive crises in sickle cell disease.
Topics: Anemia, Sickle Cell; Anesthetics, Dissociative; Arterial Occlusive Diseases; Drug Tolerance; Excitat | 2013 |
Ketamine and peripheral inflammation.
Topics: Analgesics; Animals; Cognition Disorders; Humans; Inflammation; Ketamine; Pain; Postoperative Compli | 2013 |
Ketamine in pain management.
Topics: Analgesics; Animals; Humans; Ketamine; Pain; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid | 2013 |
Sedation and analgesia to facilitate mechanical ventilation.
Topics: Analgesics; Analgesics, Opioid; Benzodiazepines; Clonidine; Humans; Hypnotics and Sedatives; Infant; | 2013 |
Ketamine infusion for sickle cell pain crisis refractory to opioids: a case report and review of literature.
Topics: Adult; Analgesics, Opioid; Anemia, Sickle Cell; Humans; Infusions, Intravenous; Ketamine; Male; Pain | 2014 |
Ketamine infusion for sickle cell pain crisis refractory to opioids: a case report and review of literature.
Topics: Adult; Analgesics, Opioid; Anemia, Sickle Cell; Humans; Infusions, Intravenous; Ketamine; Male; Pain | 2014 |
Ketamine infusion for sickle cell pain crisis refractory to opioids: a case report and review of literature.
Topics: Adult; Analgesics, Opioid; Anemia, Sickle Cell; Humans; Infusions, Intravenous; Ketamine; Male; Pain | 2014 |
Ketamine infusion for sickle cell pain crisis refractory to opioids: a case report and review of literature.
Topics: Adult; Analgesics, Opioid; Anemia, Sickle Cell; Humans; Infusions, Intravenous; Ketamine; Male; Pain | 2014 |
Ketamine infusion for sickle cell pain crisis refractory to opioids: a case report and review of literature.
Topics: Adult; Analgesics, Opioid; Anemia, Sickle Cell; Humans; Infusions, Intravenous; Ketamine; Male; Pain | 2014 |
Ketamine infusion for sickle cell pain crisis refractory to opioids: a case report and review of literature.
Topics: Adult; Analgesics, Opioid; Anemia, Sickle Cell; Humans; Infusions, Intravenous; Ketamine; Male; Pain | 2014 |
Ketamine infusion for sickle cell pain crisis refractory to opioids: a case report and review of literature.
Topics: Adult; Analgesics, Opioid; Anemia, Sickle Cell; Humans; Infusions, Intravenous; Ketamine; Male; Pain | 2014 |
Ketamine infusion for sickle cell pain crisis refractory to opioids: a case report and review of literature.
Topics: Adult; Analgesics, Opioid; Anemia, Sickle Cell; Humans; Infusions, Intravenous; Ketamine; Male; Pain | 2014 |
Ketamine infusion for sickle cell pain crisis refractory to opioids: a case report and review of literature.
Topics: Adult; Analgesics, Opioid; Anemia, Sickle Cell; Humans; Infusions, Intravenous; Ketamine; Male; Pain | 2014 |
Analgesic effects of topical ketamine.
Topics: Administration, Topical; Analgesics; Humans; Ketamine; Neuralgia; Pain; Pain Management | 2015 |
Ketamine-an update on its clinical uses and abuses.
Topics: Analgesics; Animals; Asthma; Depressive Disorder, Major; Gastrointestinal Tract; Humans; Ketamine; P | 2014 |
Complex regional pain syndrome: An optimistic perspective.
Topics: Analgesics; Autonomic Nervous System Diseases; Bone Density Conservation Agents; Complex Regional Pa | 2015 |
Complex regional pain syndrome: An optimistic perspective.
Topics: Analgesics; Autonomic Nervous System Diseases; Bone Density Conservation Agents; Complex Regional Pa | 2015 |
Complex regional pain syndrome: An optimistic perspective.
Topics: Analgesics; Autonomic Nervous System Diseases; Bone Density Conservation Agents; Complex Regional Pa | 2015 |
Complex regional pain syndrome: An optimistic perspective.
Topics: Analgesics; Autonomic Nervous System Diseases; Bone Density Conservation Agents; Complex Regional Pa | 2015 |
Ameliorating treatment-refractory depression with intranasal ketamine: potential NMDA receptor actions in the pain circuitry representing mental anguish.
Topics: Administration, Intranasal; Animals; Cerebral Cortex; Depressive Disorder, Treatment-Resistant; Exci | 2016 |
Pharmacotherapy for pain: efficacy and safety issues examined by subgroup analyses.
Topics: Analgesics; Analgesics, Opioid; Animals; Capsaicin; Humans; Ketamine; Pain; Pain Measurement; Respir | 2015 |
Ketamine.
Topics: Analgesics; Animals; Hospice Care; Humans; Ketamine; Neoplasms; Pain; Palliative Care | 2015 |
Ketamine-Propofol Versus Propofol Alone for Procedural Sedation in the Emergency Department: A Systematic Review and Meta-analysis.
Topics: Conscious Sedation; Drug Therapy, Combination; Emergency Service, Hospital; Humans; Hypnotics and Se | 2015 |
Ketamine use in current clinical practice.
Topics: Depression; Humans; Ketamine; Pain; Pain Management; Suicide Prevention | 2016 |
Ketamine: A Review of Clinical Pharmacokinetics and Pharmacodynamics in Anesthesia and Pain Therapy.
Topics: Analgesics; Anesthesia; Animals; Biological Availability; Central Nervous System; Child; Cytochrome | 2016 |
Analgesia in the surgical intensive care unit.
Topics: Acetaminophen; Amines; Analgesics; Analgesics, Opioid; Anesthesia, Conduction; Anesthetics, Local; C | 2017 |
Ketamine Infusion for Pain Control in Acute Pediatric Sickle Cell Painful Crises.
Topics: Analgesics; Anemia, Sickle Cell; Child; Humans; Infusions, Intravenous; Ketamine; Pain; Pain Managem | 2019 |
Ketamine: An Update on Cellular and Subcellular Mechanisms with Implications for Clinical Practice.
Topics: Analgesics; Anesthetics, Dissociative; Humans; Ketamine; Pain; Receptors, N-Methyl-D-Aspartate | 2017 |
Low dose ketamine use in the emergency department, a new direction in pain management.
Topics: Analgesics; Analgesics, Opioid; Drug Therapy, Combination; Emergency Service, Hospital; Humans; Keta | 2017 |
Low dose ketamine use in the emergency department, a new direction in pain management.
Topics: Analgesics; Analgesics, Opioid; Drug Therapy, Combination; Emergency Service, Hospital; Humans; Keta | 2017 |
Low dose ketamine use in the emergency department, a new direction in pain management.
Topics: Analgesics; Analgesics, Opioid; Drug Therapy, Combination; Emergency Service, Hospital; Humans; Keta | 2017 |
Low dose ketamine use in the emergency department, a new direction in pain management.
Topics: Analgesics; Analgesics, Opioid; Drug Therapy, Combination; Emergency Service, Hospital; Humans; Keta | 2017 |
Low dose ketamine use in the emergency department, a new direction in pain management.
Topics: Analgesics; Analgesics, Opioid; Drug Therapy, Combination; Emergency Service, Hospital; Humans; Keta | 2017 |
Low dose ketamine use in the emergency department, a new direction in pain management.
Topics: Analgesics; Analgesics, Opioid; Drug Therapy, Combination; Emergency Service, Hospital; Humans; Keta | 2017 |
Low dose ketamine use in the emergency department, a new direction in pain management.
Topics: Analgesics; Analgesics, Opioid; Drug Therapy, Combination; Emergency Service, Hospital; Humans; Keta | 2017 |
Low dose ketamine use in the emergency department, a new direction in pain management.
Topics: Analgesics; Analgesics, Opioid; Drug Therapy, Combination; Emergency Service, Hospital; Humans; Keta | 2017 |
Low dose ketamine use in the emergency department, a new direction in pain management.
Topics: Analgesics; Analgesics, Opioid; Drug Therapy, Combination; Emergency Service, Hospital; Humans; Keta | 2017 |
Low dose ketamine use in the emergency department, a new direction in pain management.
Topics: Analgesics; Analgesics, Opioid; Drug Therapy, Combination; Emergency Service, Hospital; Humans; Keta | 2017 |
Low dose ketamine use in the emergency department, a new direction in pain management.
Topics: Analgesics; Analgesics, Opioid; Drug Therapy, Combination; Emergency Service, Hospital; Humans; Keta | 2017 |
Low dose ketamine use in the emergency department, a new direction in pain management.
Topics: Analgesics; Analgesics, Opioid; Drug Therapy, Combination; Emergency Service, Hospital; Humans; Keta | 2017 |
Low dose ketamine use in the emergency department, a new direction in pain management.
Topics: Analgesics; Analgesics, Opioid; Drug Therapy, Combination; Emergency Service, Hospital; Humans; Keta | 2017 |
Low dose ketamine use in the emergency department, a new direction in pain management.
Topics: Analgesics; Analgesics, Opioid; Drug Therapy, Combination; Emergency Service, Hospital; Humans; Keta | 2017 |
Low dose ketamine use in the emergency department, a new direction in pain management.
Topics: Analgesics; Analgesics, Opioid; Drug Therapy, Combination; Emergency Service, Hospital; Humans; Keta | 2017 |
Low dose ketamine use in the emergency department, a new direction in pain management.
Topics: Analgesics; Analgesics, Opioid; Drug Therapy, Combination; Emergency Service, Hospital; Humans; Keta | 2017 |
Efficacy of lidocaine on preventing incidence and severity of pain associated with propofol using in pediatric patients: A PRISMA-compliant meta-analysis of randomized controlled trials.
Topics: Adolescent; Alfentanil; Anesthetics, Intravenous; Anesthetics, Local; Child; Double-Blind Method; Hu | 2017 |
The evolution of pain management in the critically ill trauma patient: Emerging concepts from the global war on terrorism.
Topics: Analgesia; Analgesics; Analgesics, Opioid; Anesthesia, Conduction; Anti-Inflammatory Agents, Non-Ste | 2008 |
The evolution of pain management in the critically ill trauma patient: Emerging concepts from the global war on terrorism.
Topics: Analgesia; Analgesics; Analgesics, Opioid; Anesthesia, Conduction; Anti-Inflammatory Agents, Non-Ste | 2008 |
The evolution of pain management in the critically ill trauma patient: Emerging concepts from the global war on terrorism.
Topics: Analgesia; Analgesics; Analgesics, Opioid; Anesthesia, Conduction; Anti-Inflammatory Agents, Non-Ste | 2008 |
The evolution of pain management in the critically ill trauma patient: Emerging concepts from the global war on terrorism.
Topics: Analgesia; Analgesics; Analgesics, Opioid; Anesthesia, Conduction; Anti-Inflammatory Agents, Non-Ste | 2008 |
[Central and peripheral mechanisms in antinociception: current and future perspectives].
Topics: Amines; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Bridged Bicyclo Compounds, Heterocycl | 2008 |
Ketamine for chronic non-cancer pain.
Topics: Analgesics; Animals; Chronic Disease; Drug Administration Routes; Humans; Ketamine; Pain | 2009 |
Ketamine for chronic non-cancer pain.
Topics: Analgesics; Animals; Chronic Disease; Drug Administration Routes; Humans; Ketamine; Pain | 2009 |
Ketamine for chronic non-cancer pain.
Topics: Analgesics; Animals; Chronic Disease; Drug Administration Routes; Humans; Ketamine; Pain | 2009 |
Ketamine for chronic non-cancer pain.
Topics: Analgesics; Animals; Chronic Disease; Drug Administration Routes; Humans; Ketamine; Pain | 2009 |
Intravenous infusion tests have limited utility for selecting long-term drug therapy in patients with chronic pain: a systematic review.
Topics: Adrenergic alpha-Antagonists; Analgesics, Opioid; Anesthetics, Dissociative; Anesthetics, Local; Chr | 2009 |
Use of oral ketamine in chronic pain management: a review.
Topics: Administration, Oral; Analgesics; Chronic Disease; Humans; Ketamine; Pain | 2010 |
[Treatment of acute pain during drug-assisted rehabilitation].
Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents | 2010 |
Pain management in the paediatric population: the regulatory situation in Europe.
Topics: Adolescent; Analgesics; Buprenorphine; Child; Child, Preschool; Clonidine; Drug and Narcotic Control | 2010 |
Ketamine for the treatment of chronic non-cancer pain.
Topics: Analgesics; Chronic Disease; Humans; Infusions, Intravenous; Ketamine; Pain; Pain Measurement; Recep | 2010 |
NMDA receptor antagonists and pain: ketamine.
Topics: Animals; Excitatory Amino Acid Antagonists; Horse Diseases; Horses; Ketamine; Pain; Receptors, N-Met | 2010 |
[Pain management of burn injuries].
Topics: Analgesics; Analgesics, Opioid; Anesthesia, Conduction; Anesthetics, Dissociative; Anti-Inflammatory | 2011 |
Pharmacotherapy for acute pain in children: current practice and recent advances.
Topics: Acetaminophen; Acute Disease; Adolescent; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents, | 2011 |
Recreational ketamine: from pleasure to pain.
Topics: Adolescent; Adult; Analgesics; Epidemiologic Methods; Humans; Illicit Drugs; Ketamine; Middle Aged; | 2011 |
Ketamine*.
Topics: Anesthesia; Anesthetics, Dissociative; Animals; Excitatory Amino Acid Antagonists; Humans; Ketamine; | 2011 |
Ketamine in pain management.
Topics: Analgesics; Analgesics, Opioid; Chronic Disease; Drug Therapy, Combination; Humans; Ketamine; Pain | 2011 |
Ketamine as an analgesic in the pre-hospital setting: a systematic review.
Topics: Analgesics; Emergency Medical Services; Humans; Ketamine; Pain; Randomized Controlled Trials as Topi | 2011 |
Ketamine as an analgesic in the pre-hospital setting: a systematic review.
Topics: Analgesics; Emergency Medical Services; Humans; Ketamine; Pain; Randomized Controlled Trials as Topi | 2011 |
Ketamine as an analgesic in the pre-hospital setting: a systematic review.
Topics: Analgesics; Emergency Medical Services; Humans; Ketamine; Pain; Randomized Controlled Trials as Topi | 2011 |
Ketamine as an analgesic in the pre-hospital setting: a systematic review.
Topics: Analgesics; Emergency Medical Services; Humans; Ketamine; Pain; Randomized Controlled Trials as Topi | 2011 |
Oral ketamine in the palliative care setting: a review of the literature and case report of a patient with neurofibromatosis type 1 and glomus tumor-associated complex regional pain syndrome.
Topics: Administration, Oral; Adult; Analgesics; Complex Regional Pain Syndromes; Female; Glomus Tumor; Huma | 2012 |
A systematic review of ketamine as an analgesic agent in adult burn injuries.
Topics: Analgesics, Opioid; Anesthetics, Dissociative; Burns; Databases, Factual; Humans; Ketamine; Pain; Pa | 2011 |
Ketamine for treatment-resistant unipolar depression: current evidence.
Topics: Antidepressive Agents; Cognition; Depressive Disorder; Depressive Disorder, Treatment-Resistant; Dru | 2012 |
[Sedation and analgesia in emergency structure. Paediatry: Which sedation and analgesia for the child under spontaneous ventilation?].
Topics: Analgesia; Analgesics; Analgesics, Opioid; Anesthesia, Conduction; Anesthesia, Local; Anesthetics, D | 2012 |
Ketamine for pain: an update of uses in palliative care.
Topics: Anesthetics, Dissociative; Humans; Ischemia; Ketamine; Neoplasms; Neuralgia; Pain; Palliative Care; | 2012 |
Ketamine as an adjuvant to opioids for cancer pain.
Topics: Adult; Analgesics; Chemotherapy, Adjuvant; Drug Therapy, Combination; Hallucinations; Humans; Ketami | 2012 |
Ketamine, propofol, and ketofol use for pediatric sedation.
Topics: Adolescent; Amnesia; Analgesia; Analgesics, Non-Narcotic; Anesthetics, Dissociative; Antiemetics; An | 2012 |
Adjuvant ketamine analgesia for the management of cancer pain.
Topics: Adult; Analgesics; Germinoma; Humans; Injections, Intravenous; Ketamine; Male; Neoplasms; Pain; Test | 2002 |
Intrathecal therapy for chronic pain.
Topics: Administration, Oral; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Chronic Disease; Hum | 2001 |
Analgesia in critical care.
Topics: Analgesics; Anesthetics, Local; Animals; Anti-Inflammatory Agents, Non-Steroidal; Critical Care; Ket | 2002 |
Ketamine as an adjuvant to opioids for cancer pain.
Topics: Adult; Analgesics; Chemotherapy, Adjuvant; Hallucinations; Humans; Ketamine; Morphine; Neoplasms; Pa | 2003 |
Ketamine as adjuvant to opioids for cancer pain. A qualitative systematic review.
Topics: Analgesics; Drug Therapy, Combination; Humans; Ketamine; Narcotics; Neoplasms; Pain; Palliative Care | 2003 |
[Palliative care for colon cancer patients as total pain management].
Topics: Analgesia, Epidural; Anticonvulsants; Antidepressive Agents; Colonic Neoplasms; Drug Therapy, Combin | 2003 |
Ketamine in chronic pain management: an evidence-based review.
Topics: Chronic Disease; Evidence-Based Medicine; Excitatory Amino Acid Antagonists; Humans; Ketamine; Pain | 2003 |
Ketamine in chronic pain management: an evidence-based review.
Topics: Chronic Disease; Evidence-Based Medicine; Excitatory Amino Acid Antagonists; Humans; Ketamine; Pain | 2003 |
Ketamine in chronic pain management: an evidence-based review.
Topics: Chronic Disease; Evidence-Based Medicine; Excitatory Amino Acid Antagonists; Humans; Ketamine; Pain | 2003 |
Ketamine in chronic pain management: an evidence-based review.
Topics: Chronic Disease; Evidence-Based Medicine; Excitatory Amino Acid Antagonists; Humans; Ketamine; Pain | 2003 |
Morphine is not the only analgesic in palliative care: literature review.
Topics: Analgesics; Analgesics, Opioid; Fentanyl; Humans; Ketamine; Methadone; Morphine; Neoplasms; Pain; Pa | 2004 |
A qualitative systematic review of the role of N-methyl-D-aspartate receptor antagonists in preventive analgesia.
Topics: Analgesics, Opioid; Anesthetics, Dissociative; Clinical Trials as Topic; Dextromethorphan; Excitator | 2004 |
Is intranasal ketamine an appropriate treatment for chronic non-cancer breakthrough pain?
Topics: Administration, Intranasal; Analgesics; Chronic Disease; Humans; Ketamine; Pain | 2004 |
Ketamine as adjuvant analgesic to opioids: a quantitative and qualitative systematic review.
Topics: Adult; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, Dissocia | 2004 |
Ketamine as adjuvant analgesic to opioids: a quantitative and qualitative systematic review.
Topics: Adult; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, Dissocia | 2004 |
Ketamine as adjuvant analgesic to opioids: a quantitative and qualitative systematic review.
Topics: Adult; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, Dissocia | 2004 |
Ketamine as adjuvant analgesic to opioids: a quantitative and qualitative systematic review.
Topics: Adult; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, Dissocia | 2004 |
Ketamine as adjuvant analgesic to opioids: a quantitative and qualitative systematic review.
Topics: Adult; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, Dissocia | 2004 |
Ketamine as adjuvant analgesic to opioids: a quantitative and qualitative systematic review.
Topics: Adult; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, Dissocia | 2004 |
Ketamine as adjuvant analgesic to opioids: a quantitative and qualitative systematic review.
Topics: Adult; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, Dissocia | 2004 |
Ketamine as adjuvant analgesic to opioids: a quantitative and qualitative systematic review.
Topics: Adult; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, Dissocia | 2004 |
Ketamine as adjuvant analgesic to opioids: a quantitative and qualitative systematic review.
Topics: Adult; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, Dissocia | 2004 |
Ketamine as adjuvant analgesic to opioids: a quantitative and qualitative systematic review.
Topics: Adult; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, Dissocia | 2004 |
Ketamine as adjuvant analgesic to opioids: a quantitative and qualitative systematic review.
Topics: Adult; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, Dissocia | 2004 |
Ketamine as adjuvant analgesic to opioids: a quantitative and qualitative systematic review.
Topics: Adult; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, Dissocia | 2004 |
Ketamine as adjuvant analgesic to opioids: a quantitative and qualitative systematic review.
Topics: Adult; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, Dissocia | 2004 |
Ketamine as adjuvant analgesic to opioids: a quantitative and qualitative systematic review.
Topics: Adult; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, Dissocia | 2004 |
Ketamine as adjuvant analgesic to opioids: a quantitative and qualitative systematic review.
Topics: Adult; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, Dissocia | 2004 |
Ketamine as adjuvant analgesic to opioids: a quantitative and qualitative systematic review.
Topics: Adult; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, Dissocia | 2004 |
Should ketamine be used as a regular analgesic for patients with chronic pain?
Topics: Analgesics; Chronic Disease; Humans; Ketamine; Pain | 2004 |
Ketamine for perioperative pain management.
Topics: Analgesia; Anesthesia, Conduction; Anesthesia, General; Anesthetics, Dissociative; Humans; Ketamine; | 2005 |
Ketamine for perioperative pain management.
Topics: Analgesia; Anesthesia, Conduction; Anesthesia, General; Anesthetics, Dissociative; Humans; Ketamine; | 2005 |
Ketamine for perioperative pain management.
Topics: Analgesia; Anesthesia, Conduction; Anesthesia, General; Anesthetics, Dissociative; Humans; Ketamine; | 2005 |
Ketamine for perioperative pain management.
Topics: Analgesia; Anesthesia, Conduction; Anesthesia, General; Anesthetics, Dissociative; Humans; Ketamine; | 2005 |
Parenteral ketamine as an analgesic adjuvant for severe pain: development and retrospective audit of a protocol for a palliative care unit.
Topics: Adult; Aged; Analgesics; Dose-Response Relationship, Drug; Female; Humans; Infusions, Parenteral; Ke | 2005 |
Pain control: ketamine: low doses may provide relief for some painful conditions.
Topics: Analgesics; Chronic Disease; Drug Monitoring; Humans; Ketamine; Neoplasms; Pain | 2005 |
Pain management in the wilderness and operational setting.
Topics: Analgesia; Analgesics; Analgesics, Opioid; Anesthesia, Conduction; Anti-Inflammatory Agents, Non-Ste | 2005 |
Metabolic and endocrine effects of sedative agents.
Topics: Adrenergic alpha-Agonists; Analgesics; Analgesics, Opioid; Benzodiazepines; Catecholamines; Combined | 2005 |
Pharmacologic management of cancer pain.
Topics: Adrenal Cortex Hormones; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthetics, Loca | 2005 |
Prevention of central sensitization and pain by N-methyl-D-aspartate receptor antagonists.
Topics: Analgesics; Animals; Excitatory Amino Acid Antagonists; Ketamine; Pain; Receptors, N-Methyl-D-Aspart | 2006 |
The potential role of ketamine in hospice analgesia: a literature review.
Topics: Analgesics; Clinical Trials as Topic; Drug Therapy, Combination; Hospices; Humans; Ketamine; Narcoti | 2006 |
The role of ketamine in pain management.
Topics: Analgesics; Chronic Disease; Humans; Ketamine; Neoplasms; Pain | 2006 |
The role of ketamine in pain management.
Topics: Analgesics; Chronic Disease; Humans; Ketamine; Neoplasms; Pain | 2006 |
The role of ketamine in pain management.
Topics: Analgesics; Chronic Disease; Humans; Ketamine; Neoplasms; Pain | 2006 |
The role of ketamine in pain management.
Topics: Analgesics; Chronic Disease; Humans; Ketamine; Neoplasms; Pain | 2006 |
Symptomatic management of calciphylaxis: a case series and review of the literature.
Topics: Aged; Analgesics; Analgesics, Opioid; Benzodiazepines; Calciphylaxis; Female; Humans; Hyperesthesia; | 2006 |
Low-dose ketamine in addition to propofol for procedural sedation and analgesia in the emergency department.
Topics: Analgesics; Anesthetics, Dissociative; Conscious Sedation; Drug Therapy, Combination; Emergency Serv | 2007 |
Pharmacological approaches to the management of pain in the neonatal intensive care unit.
Topics: Analgesics; Analgesics, Opioid; Female; Humans; Infant, Newborn; Infant, Premature; Intensive Care U | 2007 |
Low dose ketamine: a therapeutic and research tool to explore N-methyl-D-aspartate (NMDA) receptor-mediated plasticity in pain pathways.
Topics: Animals; Excitatory Amino Acid Antagonists; Humans; Ketamine; Neuronal Plasticity; Pain; Receptors, | 2007 |
Ketamine: a controversial drug for neonates.
Topics: Anesthetics, Dissociative; Clinical Trials as Topic; Humans; Infant; Infant, Newborn; Ketamine; Pain | 2007 |
Recent advances in the pharmacological management of pain.
Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthetics, Local; Animals | 2007 |
The management of pain in children with life-limiting illnesses.
Topics: Analgesics, Opioid; Child; Chronic Disease; Codeine; Fentanyl; Humans; Hydromorphone; Ketamine; Meth | 2007 |
Combination ketamine and propofol for procedural sedation and analgesia.
Topics: Analgesics; Anesthetics, Dissociative; Conscious Sedation; Controlled Clinical Trials as Topic; Drug | 2007 |
Ketamine.
Topics: Analgesics; Anesthetics, Dissociative; Animals; Central Nervous System; Contraindications; Dose-Resp | 2008 |
The use of ketamine as adjuvant therapy to control severe pain.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Drug Monitoring; Drug Therapy, | 2008 |
Systemic analgesia during labor.
Topics: Acid-Base Equilibrium; Analgesics; Animals; Child Behavior; Diazepam; Female; Fentanyl; Fetal Heart; | 1982 |
Spinal antinociception: clinical aspects.
Topics: Adrenergic alpha-Agonists; Analgesia, Epidural; Analgesics; Clinical Trials as Topic; Clonidine; Dru | 1995 |
Clinical applications of excitatory amino acid antagonists in pain management.
Topics: Analgesia; Excitatory Amino Acid Antagonists; Excitatory Amino Acids; Humans; Ketamine; Pain; Recept | 1995 |
Ketamine in cancer pain: an update.
Topics: Analgesics, Opioid; Biological Availability; Drug Synergism; Drug Tolerance; Excitatory Amino Acid A | 1996 |
[Treatment of pain in oncology].
Topics: Administration, Cutaneous; Analgesics, Opioid; Anesthetics, Dissociative; Diphosphonates; Fentanyl; | 1997 |
Combined opioid-NMDA antagonist therapies. What advantages do they offer for the control of pain syndromes?
Topics: Analgesics, Opioid; Clinical Trials as Topic; Drug Synergism; Drug Therapy, Combination; Drug Tolera | 1998 |
Intravenous analgesia.
Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthetics, Dissociative; Critical Care; Humans; Inje | 1999 |
NMDA-receptor antagonists in neuropathic pain: experimental methods to clinical trials.
Topics: Analgesics; Clinical Trials as Topic; Dextromethorphan; Excitatory Amino Acid Antagonists; Humans; K | 2000 |
Advances in cancer pain management.
Topics: Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Bone Diseases; Bone Neoplasms; Chemothe | 2000 |
Management of acute pain and anxiety in children undergoing procedures in the emergency department.
Topics: Acute Disease; Analgesia; Analgesics; Anesthesia, Local; Anxiety; Child; Child, Hospitalized; Emerge | 2001 |
The role of nicotinic acetylcholine receptors in the mechanisms of anesthesia.
Topics: Acetylcholine; Analgesics; Anesthesia; Anesthetics; Anesthetics, Inhalation; Animals; Binding, Compe | 2002 |
Current views on the role of opioid receptors and endorphins in anesthesiology.
Topics: Acute Disease; Anesthesia; Animals; Blood Circulation; Chronic Disease; Endorphins; Halothane; Human | 1986 |
Trials
134 trials available for ketamine and Ache
| Article | Year |
|---|---|
Plasma inflammatory cytokines and treatment-resistant depression with comorbid pain: improvement by ketamine.
Topics: Case-Control Studies; Cytokines; Depression; Depressive Disorder, Treatment-Resistant; Humans; Ketam | 2021 |
'NOPAIN-ROP' trial: Intravenous fentanyl and intravenous ketamine for pain relief during laser photocoagulation for retinopathy of prematurity (ROP) in preterm infants: A randomised trial.
Topics: Fentanyl; Humans; Infant; Infant, Newborn; Infant, Premature; Ketamine; Lasers; Light Coagulation; P | 2021 |
Comparing the Efficacy and Safety of Dexmedetomidine/Ketamine with Propofol/Fentanyl for Sedation in Colonoscopy Patients: A Doubleblinded Randomized Clinical Trial.
Topics: Apnea; Colonoscopy; Dexmedetomidine; Double-Blind Method; Fentanyl; Humans; Hypnotics and Sedatives; | 2022 |
Ketamine Compared With Fentanyl for Surgical Abortion: A Randomized Controlled Trial.
Topics: Double-Blind Method; Female; Fentanyl; Humans; Ketamine; Midazolam; Pain; Pregnancy | 2022 |
Pretreatment with Low-Dose Esketamine for Reduction of Propofol Injection Pain: A Randomized Controlled Trial.
Topics: Anesthetics, Intravenous; Double-Blind Method; Humans; Ketamine; Lidocaine; Pain; Propofol | 2022 |
Comparison of Propofol-Fentanyl with Midazolam-Ketamine Combination in Pediatric Patients Undergoing Kidney Biopsy.
Topics: Analgesics; Biopsy; Child; Fentanyl; Humans; Ketamine; Kidney; Midazolam; Pain; Propofol | 2022 |
The efficacy and safety of midazolam with fentanyl versus midazolam with ketamine for bedside invasive procedural sedation in pediatric oncology patients: A randomized, double-blinded, crossover trial.
Topics: Child; Cross-Over Studies; Fentanyl; Humans; Hypnotics and Sedatives; Ketamine; Midazolam; Neoplasms | 2022 |
Ketamine and dexmedetomidine (Keto-dex) or ketamine and propofol (Keto-fol) for procedural sedation during endoscopic retrograde cholangiopancreatography: Which is safer? A randomized clinical trial.
Topics: Adolescent; Adult; Aged; Cholangiopancreatography, Endoscopic Retrograde; Conscious Sedation; Dexmed | 2022 |
Comparing the Effects of Low-Dose Ketamine, Fentanyl, and Morphine on Hemorrhagic Tolerance and Analgesia in Humans.
Topics: Adult; Analgesia; Analgesics; Analgesics, Opioid; Cross-Over Studies; Emergency Medical Services; Fe | 2023 |
Efficacy of ketamine mouthwash in the management of oral and pharyngeal toxicity associated with head and neck chemoradiotherapy: protocol for a phase II, Simon's two-stage trial.
Topics: Analgesics, Opioid; Chemoradiotherapy; Clinical Trials, Phase II as Topic; Head and Neck Neoplasms; | 2023 |
Brain connectivity under light sedation with midazolam and ketamine during task performance and the periodic experience of pain: Examining concordance between different approaches for seed-based connectivity analysis.
Topics: Adult; Brain; Humans; Ketamine; Magnetic Resonance Imaging; Midazolam; Pain; Task Performance and An | 2023 |
Midazolam and Ketamine Produce Distinct Neural Changes in Memory, Pain, and Fear Networks during Pain.
Topics: Adolescent; Adult; Analgesics; Anesthetics, Intravenous; Brain; Cross-Over Studies; Fear; Female; Hu | 2021 |
Single bolus low-dose of ketamine does not prevent postpartum depression: a randomized, double-blind, placebo-controlled, prospective clinical trial.
Topics: Adult; Cesarean Section; Depression, Postpartum; Double-Blind Method; Female; Humans; Ketamine; Pain | 2017 |
Subdissociative intranasal ketamine plus standard pain therapy versus standard pain therapy in the treatment of paediatric sickle cell disease vaso-occlusive crises in resource-limited settings: study protocol for a randomised controlled trial.
Topics: Administration, Intranasal; Adolescent; Analgesics; Anemia, Sickle Cell; Cameroon; Child; Child, Pre | 2017 |
Slow Infusion of Low-dose Ketamine Reduces Bothersome Side Effects Compared to Intravenous Push: A Double-blind, Double-dummy, Randomized Controlled Trial.
Topics: Adult; Analgesics; Double-Blind Method; Female; Humans; Infusions, Intravenous; Injections, Intraven | 2018 |
Slow Infusion of Low-dose Ketamine Reduces Bothersome Side Effects Compared to Intravenous Push: A Double-blind, Double-dummy, Randomized Controlled Trial.
Topics: Adult; Analgesics; Double-Blind Method; Female; Humans; Infusions, Intravenous; Injections, Intraven | 2018 |
Slow Infusion of Low-dose Ketamine Reduces Bothersome Side Effects Compared to Intravenous Push: A Double-blind, Double-dummy, Randomized Controlled Trial.
Topics: Adult; Analgesics; Double-Blind Method; Female; Humans; Infusions, Intravenous; Injections, Intraven | 2018 |
Slow Infusion of Low-dose Ketamine Reduces Bothersome Side Effects Compared to Intravenous Push: A Double-blind, Double-dummy, Randomized Controlled Trial.
Topics: Adult; Analgesics; Double-Blind Method; Female; Humans; Infusions, Intravenous; Injections, Intraven | 2018 |
Slow Infusion of Low-dose Ketamine Reduces Bothersome Side Effects Compared to Intravenous Push: A Double-blind, Double-dummy, Randomized Controlled Trial.
Topics: Adult; Analgesics; Double-Blind Method; Female; Humans; Infusions, Intravenous; Injections, Intraven | 2018 |
Slow Infusion of Low-dose Ketamine Reduces Bothersome Side Effects Compared to Intravenous Push: A Double-blind, Double-dummy, Randomized Controlled Trial.
Topics: Adult; Analgesics; Double-Blind Method; Female; Humans; Infusions, Intravenous; Injections, Intraven | 2018 |
Slow Infusion of Low-dose Ketamine Reduces Bothersome Side Effects Compared to Intravenous Push: A Double-blind, Double-dummy, Randomized Controlled Trial.
Topics: Adult; Analgesics; Double-Blind Method; Female; Humans; Infusions, Intravenous; Injections, Intraven | 2018 |
Slow Infusion of Low-dose Ketamine Reduces Bothersome Side Effects Compared to Intravenous Push: A Double-blind, Double-dummy, Randomized Controlled Trial.
Topics: Adult; Analgesics; Double-Blind Method; Female; Humans; Infusions, Intravenous; Injections, Intraven | 2018 |
Slow Infusion of Low-dose Ketamine Reduces Bothersome Side Effects Compared to Intravenous Push: A Double-blind, Double-dummy, Randomized Controlled Trial.
Topics: Adult; Analgesics; Double-Blind Method; Female; Humans; Infusions, Intravenous; Injections, Intraven | 2018 |
Analgesic Efficacy of Intranasal Ketamine Versus Intranasal Fentanyl for Moderate to Severe Pain in Children: A Prospective, Randomized, Double-Blind Study.
Topics: Administration, Intranasal; Adolescent; Analgesics; Child; Child, Preschool; Double-Blind Method; Fe | 2021 |
Effect of Intranasal Ketamine vs Fentanyl on Pain Reduction for Extremity Injuries in Children: The PRIME Randomized Clinical Trial.
Topics: Administration, Intranasal; Adolescent; Analgesics; Analgesics, Opioid; Child; Double-Blind Method; | 2019 |
Sub-dissociative dose intranasal ketamine for limb injury pain in children in the emergency department: a pilot study.
Topics: Administration, Intranasal; Adolescent; Analgesics; Australia; Child; Child, Preschool; Dose-Respons | 2013 |
Sub-dissociative dose intranasal ketamine for limb injury pain in children in the emergency department: a pilot study.
Topics: Administration, Intranasal; Adolescent; Analgesics; Australia; Child; Child, Preschool; Dose-Respons | 2013 |
Sub-dissociative dose intranasal ketamine for limb injury pain in children in the emergency department: a pilot study.
Topics: Administration, Intranasal; Adolescent; Analgesics; Australia; Child; Child, Preschool; Dose-Respons | 2013 |
Sub-dissociative dose intranasal ketamine for limb injury pain in children in the emergency department: a pilot study.
Topics: Administration, Intranasal; Adolescent; Analgesics; Australia; Child; Child, Preschool; Dose-Respons | 2013 |
Sub-dissociative dose intranasal ketamine for limb injury pain in children in the emergency department: a pilot study.
Topics: Administration, Intranasal; Adolescent; Analgesics; Australia; Child; Child, Preschool; Dose-Respons | 2013 |
Sub-dissociative dose intranasal ketamine for limb injury pain in children in the emergency department: a pilot study.
Topics: Administration, Intranasal; Adolescent; Analgesics; Australia; Child; Child, Preschool; Dose-Respons | 2013 |
Sub-dissociative dose intranasal ketamine for limb injury pain in children in the emergency department: a pilot study.
Topics: Administration, Intranasal; Adolescent; Analgesics; Australia; Child; Child, Preschool; Dose-Respons | 2013 |
Sub-dissociative dose intranasal ketamine for limb injury pain in children in the emergency department: a pilot study.
Topics: Administration, Intranasal; Adolescent; Analgesics; Australia; Child; Child, Preschool; Dose-Respons | 2013 |
Sub-dissociative dose intranasal ketamine for limb injury pain in children in the emergency department: a pilot study.
Topics: Administration, Intranasal; Adolescent; Analgesics; Australia; Child; Child, Preschool; Dose-Respons | 2013 |
Sub-dissociative dose intranasal ketamine for limb injury pain in children in the emergency department: a pilot study.
Topics: Administration, Intranasal; Adolescent; Analgesics; Australia; Child; Child, Preschool; Dose-Respons | 2013 |
Sub-dissociative dose intranasal ketamine for limb injury pain in children in the emergency department: a pilot study.
Topics: Administration, Intranasal; Adolescent; Analgesics; Australia; Child; Child, Preschool; Dose-Respons | 2013 |
Sub-dissociative dose intranasal ketamine for limb injury pain in children in the emergency department: a pilot study.
Topics: Administration, Intranasal; Adolescent; Analgesics; Australia; Child; Child, Preschool; Dose-Respons | 2013 |
Sub-dissociative dose intranasal ketamine for limb injury pain in children in the emergency department: a pilot study.
Topics: Administration, Intranasal; Adolescent; Analgesics; Australia; Child; Child, Preschool; Dose-Respons | 2013 |
Sub-dissociative dose intranasal ketamine for limb injury pain in children in the emergency department: a pilot study.
Topics: Administration, Intranasal; Adolescent; Analgesics; Australia; Child; Child, Preschool; Dose-Respons | 2013 |
Sub-dissociative dose intranasal ketamine for limb injury pain in children in the emergency department: a pilot study.
Topics: Administration, Intranasal; Adolescent; Analgesics; Australia; Child; Child, Preschool; Dose-Respons | 2013 |
Sub-dissociative dose intranasal ketamine for limb injury pain in children in the emergency department: a pilot study.
Topics: Administration, Intranasal; Adolescent; Analgesics; Australia; Child; Child, Preschool; Dose-Respons | 2013 |
A double-blind, randomised, placebo-controlled trial of oral midazolam plus oral ketamine for sedation of children during laceration repair.
Topics: Administration, Oral; Anesthetics, Dissociative; Child; Child, Preschool; Conscious Sedation; Double | 2014 |
Long-term pain prevalence and health-related quality of life outcomes for patients enrolled in a ketamine versus morphine for prehospital traumatic pain randomised controlled trial.
Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics; Australia; Emergency Medicine | 2014 |
An effective dose of ketamine for eliminating pain during injection of propofol: a dose response study.
Topics: Adult; Anesthetics, Dissociative; Anesthetics, Intravenous; Dose-Response Relationship, Drug; Double | 2013 |
Efficacy of ketamine hydrochloride administered as a basilar sesamoid nerve block in alleviating foot pain in horses caused by natural disease.
Topics: Analgesics; Animals; Foot Diseases; Horse Diseases; Horses; Ketamine; Lameness, Animal; Nerve Block; | 2014 |
Anaesthetic, analgesic and cardiorespiratory effects of intramuscular medetomidine-ketamine combination alone or with morphine or tramadol for orchiectomy in cats.
Topics: Analgesia; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthetics, Combined; Anesthetics, Dissoci | 2014 |
Evaluating the hematoma block as an adjunct to procedural sedation for closed reduction of distal forearm fractures.
Topics: Adolescent; Anesthetics, Local; Child; Child, Preschool; Conscious Sedation; Double-Blind Method; Fe | 2014 |
[Periods of post-anesthetic rehabilitation and anesthesia dosage for laparoscopic cholecystectomy: retrospective investigation].
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Anesthesia, General; Anesthetics, Intraveno | 2014 |
Propofol-ketamine or propofol-remifentanil for deep sedation and analgesia in pediatric patients undergoing burn dressing changes: a randomized clinical trial.
Topics: Analgesia; Anesthesia Recovery Period; Anesthetics, Dissociative; Anesthetics, Intravenous; Bandages | 2015 |
The clinical effect of fentanyl in comparison with ketamine in analgesic effect for oncology procedures in children: a randomized, double-blinded, crossover trial.
Topics: Adolescent; Analgesics; Analgesics, Opioid; Child; Child, Preschool; Cross-Over Studies; Double-Blin | 2015 |
Effects of Different Anesthetics on Pain Processing in an Experimental Human Pain Model.
Topics: Adult; Analgesics, Opioid; Anesthetics; Female; Humans; Hyperalgesia; Ketamine; Male; Pain; Pain Mea | 2016 |
Two Different Concentrations of Ketofol for Procedural Sedation and Analgesia in Closed Reduction of Nasal Fracture.
Topics: Adolescent; Adult; Analgesia; Anesthetics, Intravenous; Child; Conscious Sedation; Double-Blind Meth | 2016 |
Study protocol of a randomised controlled trial of intranasal ketamine compared with intranasal fentanyl for analgesia in children with suspected, isolated extremity fractures in the paediatric emergency department.
Topics: Administration, Intranasal; Adolescent; Analgesia; Analgesics; Analgesics, Opioid; Child; Child, Pre | 2016 |
Serum concentration of ketamine and antinociceptive effects of ketamine and ketamine-lidocaine infusions in conscious dogs.
Topics: Analgesics; Anesthetics, Local; Animals; Cross-Over Studies; Dog Diseases; Dogs; Ketamine; Lidocaine | 2016 |
Intranasal ketamine for acute traumatic pain in the Emergency Department: a prospective, randomized clinical trial of efficacy and safety.
Topics: Administration, Intranasal; Adolescent; Adult; Aged; Analgesics; Double-Blind Method; Emergency Serv | 2016 |
Treatment of severe mucositis pain with oral ketamine mouthwash.
Topics: Adult; Aged; Female; Hematopoietic Stem Cell Transplantation; Humans; Ketamine; Male; Middle Aged; M | 2017 |
Ketamine and midazolam delivered by patient-controlled analgesia in relieving pain associated with burns dressings.
Topics: Adolescent; Adult; Aged; Analgesia, Patient-Controlled; Analgesics; Bandages; Burns; Drug Therapy, C | 2008 |
Ketamine and midazolam delivered by patient-controlled analgesia in relieving pain associated with burns dressings.
Topics: Adolescent; Adult; Aged; Analgesia, Patient-Controlled; Analgesics; Bandages; Burns; Drug Therapy, C | 2008 |
Ketamine and midazolam delivered by patient-controlled analgesia in relieving pain associated with burns dressings.
Topics: Adolescent; Adult; Aged; Analgesia, Patient-Controlled; Analgesics; Bandages; Burns; Drug Therapy, C | 2008 |
Ketamine and midazolam delivered by patient-controlled analgesia in relieving pain associated with burns dressings.
Topics: Adolescent; Adult; Aged; Analgesia, Patient-Controlled; Analgesics; Bandages; Burns; Drug Therapy, C | 2008 |
Intravenous ketamine plus midazolam vs. intravenous ketamine for sedation in lumbar puncture: a randomized controlled trial.
Topics: Adolescent; Anesthetics, Dissociative; Anesthetics, Intravenous; Child; Confidence Intervals; Dizzin | 2008 |
[Efficacy of a low dose of ketamine in reduction of propofol-injection-related pain].
Topics: Adolescent; Adult; Analgesics; Anesthetics, Intravenous; Double-Blind Method; Female; Gynecologic Su | 2009 |
Comparison of ketamine plus midazolam versus ketamine for sedation in children during lumbar puncture.
Topics: Adjuvants, Anesthesia; Adolescent; Analgesics; Child, Preschool; Drug Therapy, Combination; Female; | 2009 |
Effects of low-dose intranasal (S)-ketamine in patients with neuropathic pain.
Topics: Administration, Intranasal; Adult; Aged; Algorithms; Anesthetics, Dissociative; Cardiovascular Syste | 2010 |
Effects of low-dose intranasal (S)-ketamine in patients with neuropathic pain.
Topics: Administration, Intranasal; Adult; Aged; Algorithms; Anesthetics, Dissociative; Cardiovascular Syste | 2010 |
Effects of low-dose intranasal (S)-ketamine in patients with neuropathic pain.
Topics: Administration, Intranasal; Adult; Aged; Algorithms; Anesthetics, Dissociative; Cardiovascular Syste | 2010 |
Effects of low-dose intranasal (S)-ketamine in patients with neuropathic pain.
Topics: Administration, Intranasal; Adult; Aged; Algorithms; Anesthetics, Dissociative; Cardiovascular Syste | 2010 |
Pain relief during dressing changes of major adult burns: ideal analgesic combination with ketamine.
Topics: Adult; Analgesics; Bandages; Blood Pressure; Burns; Dexmedetomidine; Drug Therapy, Combination; Fema | 2010 |
Prevention of propofol injection pain with small-dose ketamine.
Topics: Adult; Anesthetics, Intravenous; Double-Blind Method; Female; Humans; Ketamine; Male; Pain; Propofol | 2009 |
Ketamine eliminates propofol pain but does not affect hemodynamics during induction with double-lumen tubes.
Topics: Aged; Analgesics; Anesthetics, Intravenous; Dose-Response Relationship, Drug; Female; Hemodynamics; | 2010 |
[Effects of intravenous midazolam, fentanyl or ketamine on pain relief during performance of epidural anesthesia].
Topics: Aged; Aged, 80 and over; Analgesics, Opioid; Anesthesia, Epidural; Female; Fentanyl; Humans; Hypnoti | 2009 |
Ketamine improves nasogastric tube insertion.
Topics: Administration, Intranasal; Adult; Double-Blind Method; Emergency Medicine; Female; Gels; Health Car | 2010 |
Population pharmacokinetic-pharmacodynamic modeling of ketamine-induced pain relief of chronic pain.
Topics: Adult; Analgesia; Analgesics; Chronic Disease; Dose-Response Relationship, Drug; Female; Humans; Ket | 2011 |
Propofol versus propofol/ketamine for brief painful procedures in the emergency department: clinical and bispectral index scale comparison.
Topics: Adult; Anesthesia Recovery Period; Anesthetics, Combined; Anesthetics, Dissociative; Anesthetics, In | 2010 |
A subhypnotic dose of ketamine reduces pain associated with injection of propofol and rocuronium.
Topics: Adolescent; Adult; Analgesics; Androstanols; Anesthetics, Intravenous; Dose-Response Relationship, D | 2011 |
Effect of ketamine on endogenous pain modulation in healthy volunteers.
Topics: Adult; Aged; Anesthetics, Dissociative; Area Under Curve; Cross-Over Studies; Drug Administration Sc | 2011 |
Efficacy of small doses of ketamine with morphine to decrease procedural pain responses during open wound care.
Topics: Adult; Aged; Analgesics; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; | 2011 |
Absence of long-term analgesic effect from a short-term S-ketamine infusion on fibromyalgia pain: a randomized, prospective, double blind, active placebo-controlled trial.
Topics: Analgesia; Analgesics; Double-Blind Method; Excitatory Amino Acid Antagonists; Female; Fibromyalgia; | 2011 |
Absence of long-term analgesic effect from a short-term S-ketamine infusion on fibromyalgia pain: a randomized, prospective, double blind, active placebo-controlled trial.
Topics: Analgesia; Analgesics; Double-Blind Method; Excitatory Amino Acid Antagonists; Female; Fibromyalgia; | 2011 |
Absence of long-term analgesic effect from a short-term S-ketamine infusion on fibromyalgia pain: a randomized, prospective, double blind, active placebo-controlled trial.
Topics: Analgesia; Analgesics; Double-Blind Method; Excitatory Amino Acid Antagonists; Female; Fibromyalgia; | 2011 |
Absence of long-term analgesic effect from a short-term S-ketamine infusion on fibromyalgia pain: a randomized, prospective, double blind, active placebo-controlled trial.
Topics: Analgesia; Analgesics; Double-Blind Method; Excitatory Amino Acid Antagonists; Female; Fibromyalgia; | 2011 |
Midazolam-ketamine combination for moderate sedation in upper GI endoscopy.
Topics: Adjuvants, Anesthesia; Anesthetics, Dissociative; Child; Child, Preschool; Conscious Sedation; Deep | 2012 |
Intravenous ketamine is as effective as midazolam/fentanyl for procedural sedation and analgesia in the emergency department.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthetics, Intravenous; Conscious Sedation; Emergency | 2011 |
Effect of ketamine hydrochloride on the analgesic effects of tramadol hydrochloride in horses with signs of chronic laminitis-associated pain.
Topics: Administration, Oral; Analgesics; Analgesics, Opioid; Animals; Cross-Over Studies; Female; Foot Dise | 2012 |
Prevention of propofol-induced pain in children: pretreatment with small doses of ketamine.
Topics: Analgesics; Anesthetics, Intravenous; Child; Child, Preschool; Dose-Response Relationship, Drug; Dou | 2012 |
Effect of subanesthetic ketamine on intrinsic functional brain connectivity: a placebo-controlled functional magnetic resonance imaging study in healthy male volunteers.
Topics: Adult; Anesthetics, Dissociative; Brain; Data Interpretation, Statistical; Hallucinogens; Hot Temper | 2012 |
Comparison of effects of ephedrine, lidocaine and ketamine with placebo on injection pain, hypotension and bradycardia due to propofol injection: a randomized placebo controlled clinical trial.
Topics: Adult; Anesthetics, Intravenous; Bradycardia; Double-Blind Method; Ephedrine; Female; Humans; Hypote | 2012 |
A randomized comparison of nitrous oxide versus intravenous ketamine for laceration repair in children.
Topics: Administration, Inhalation; Analgesics, Non-Narcotic; Anesthesia Recovery Period; Anesthesia, Inhala | 2012 |
A prospective, randomized, double-blind study to compare the efficacy of lidocaine + metoclopramide and lidocaine + ketamine combinations in preventing pain on propofol injection.
Topics: Adult; Anesthetics, Combined; Anesthetics, Dissociative; Anesthetics, Intravenous; Anesthetics, Loca | 2013 |
The effects of remifentanil, lidocaine, metoclopramide, or ketamine pretreatment on propofol injection pain.
Topics: Adult; Aged; Analgesics; Double-Blind Method; Female; Humans; Injections, Intravenous; Ketamine; Lid | 2012 |
Effects of low-dose ketamine on neuropathic pain: An electroencephalogram-electrooculogram/behavioral study.
Topics: Aged; Anesthetics, Dissociative; Electroencephalography; Female; Hallucinations; Humans; Injections, | 2002 |
Short- and long-term efficacy of oral ketamine in eight chronic-pain patients.
Topics: Administration, Oral; Adult; Aged; Analgesics; Chronic Disease; Excitatory Amino Acid Antagonists; F | 2002 |
Cold allodynia and hyperalgesia in neuropathic pain: the effect of N-methyl-D-aspartate (NMDA) receptor antagonist ketamine--a double-blind, cross-over comparison with alfentanil and placebo.
Topics: Adult; Aged; Alfentanil; Analgesics, Opioid; Cold Temperature; Cross-Over Studies; Double-Blind Meth | 2003 |
Short-term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal.
Topics: Adult; Analgesics, Opioid; Cross-Over Studies; Excitatory Amino Acid Antagonists; Hot Temperature; H | 2003 |
Short-term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal.
Topics: Adult; Analgesics, Opioid; Cross-Over Studies; Excitatory Amino Acid Antagonists; Hot Temperature; H | 2003 |
Short-term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal.
Topics: Adult; Analgesics, Opioid; Cross-Over Studies; Excitatory Amino Acid Antagonists; Hot Temperature; H | 2003 |
Short-term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal.
Topics: Adult; Analgesics, Opioid; Cross-Over Studies; Excitatory Amino Acid Antagonists; Hot Temperature; H | 2003 |
Short-term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal.
Topics: Adult; Analgesics, Opioid; Cross-Over Studies; Excitatory Amino Acid Antagonists; Hot Temperature; H | 2003 |
Short-term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal.
Topics: Adult; Analgesics, Opioid; Cross-Over Studies; Excitatory Amino Acid Antagonists; Hot Temperature; H | 2003 |
Short-term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal.
Topics: Adult; Analgesics, Opioid; Cross-Over Studies; Excitatory Amino Acid Antagonists; Hot Temperature; H | 2003 |
Short-term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal.
Topics: Adult; Analgesics, Opioid; Cross-Over Studies; Excitatory Amino Acid Antagonists; Hot Temperature; H | 2003 |
Short-term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal.
Topics: Adult; Analgesics, Opioid; Cross-Over Studies; Excitatory Amino Acid Antagonists; Hot Temperature; H | 2003 |
Short-term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal.
Topics: Adult; Analgesics, Opioid; Cross-Over Studies; Excitatory Amino Acid Antagonists; Hot Temperature; H | 2003 |
Short-term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal.
Topics: Adult; Analgesics, Opioid; Cross-Over Studies; Excitatory Amino Acid Antagonists; Hot Temperature; H | 2003 |
Short-term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal.
Topics: Adult; Analgesics, Opioid; Cross-Over Studies; Excitatory Amino Acid Antagonists; Hot Temperature; H | 2003 |
Short-term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal.
Topics: Adult; Analgesics, Opioid; Cross-Over Studies; Excitatory Amino Acid Antagonists; Hot Temperature; H | 2003 |
Short-term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal.
Topics: Adult; Analgesics, Opioid; Cross-Over Studies; Excitatory Amino Acid Antagonists; Hot Temperature; H | 2003 |
Short-term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal.
Topics: Adult; Analgesics, Opioid; Cross-Over Studies; Excitatory Amino Acid Antagonists; Hot Temperature; H | 2003 |
Short-term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal.
Topics: Adult; Analgesics, Opioid; Cross-Over Studies; Excitatory Amino Acid Antagonists; Hot Temperature; H | 2003 |
Pretreatment with intravenous ketamine reduces propofol injection pain.
Topics: Adolescent; Analgesics; Anesthetics, Intravenous; Anesthetics, Local; Child; Child, Preschool; Doubl | 2003 |
An investigation to dissociate the analgesic and anesthetic properties of ketamine using functional magnetic resonance imaging.
Topics: Acoustic Stimulation; Adult; Analgesia; Anesthesia; Anesthetics, Dissociative; Brain; Humans; Ketami | 2004 |
The analgesic effect of intravenous ketamine and lidocaine on pain after spinal cord injury.
Topics: Adult; Analgesics; Analysis of Variance; Anesthetics, Local; Cross-Over Studies; Double-Blind Method | 2004 |
Differential effects of peripheral ketamine and lidocaine on skin flux and hyperalgesia induced by intradermal capsaicin in humans.
Topics: Administration, Cutaneous; Analgesics; Anesthetics, Local; Capsaicin; Cross-Over Studies; Double-Bli | 2004 |
Safety and efficacy of intranasal ketamine for the treatment of breakthrough pain in patients with chronic pain: a randomized, double-blind, placebo-controlled, crossover study.
Topics: Administration, Intranasal; Adult; Aged; Analgesics; Analgesics, Opioid; Chronic Disease; Cross-Over | 2004 |
Safety and efficacy of intranasal ketamine for the treatment of breakthrough pain in patients with chronic pain: a randomized, double-blind, placebo-controlled, crossover study.
Topics: Administration, Intranasal; Adult; Aged; Analgesics; Analgesics, Opioid; Chronic Disease; Cross-Over | 2004 |
Safety and efficacy of intranasal ketamine for the treatment of breakthrough pain in patients with chronic pain: a randomized, double-blind, placebo-controlled, crossover study.
Topics: Administration, Intranasal; Adult; Aged; Analgesics; Analgesics, Opioid; Chronic Disease; Cross-Over | 2004 |
Safety and efficacy of intranasal ketamine for the treatment of breakthrough pain in patients with chronic pain: a randomized, double-blind, placebo-controlled, crossover study.
Topics: Administration, Intranasal; Adult; Aged; Analgesics; Analgesics, Opioid; Chronic Disease; Cross-Over | 2004 |
The synergistic effect of combined treatment with systemic ketamine and morphine on experimentally induced windup-like pain in humans.
Topics: Adult; Burns; Cross-Over Studies; Double-Blind Method; Drug Synergism; Drug Therapy, Combination; Fe | 2004 |
Inter- and intraindividual variability in ketamine dosage in repetitive invasive procedures in children with malignancies.
Topics: Adolescent; Anesthetics, Dissociative; Biopsy; Bone Marrow Examination; Child; Child, Preschool; Dia | 2004 |
Ketamine does not decrease postoperative pain after remifentanil-based anaesthesia for tonsillectomy in adults.
Topics: Adult; Analgesics; Analgesics, Opioid; Analysis of Variance; Anesthesia, Intravenous; Anesthetics, I | 2004 |
Conscious sedation: Off-label use of rectal S(+)-ketamine and midazolam for wound dressing changes in paediatric heat injuries.
Topics: Adjuvants, Anesthesia; Analgesics; Bandages; Burns; Child; Child, Preschool; Conscious Sedation; Dru | 2004 |
The intravenous ketamine test: a predictive response tool for oral dextromethorphan treatment in neuropathic pain.
Topics: Administration, Oral; Adult; Anesthetics, Local; Databases, Factual; Dextromethorphan; Excitatory Am | 2004 |
The effect of ketamine and fentanyl in reducing the pain of diazepam injection.
Topics: Adolescent; Adult; Analgesics; Anesthetics, Intravenous; Diazepam; Double-Blind Method; Fentanyl; Hu | 2004 |
The effects of racemic ketamine on painful stimulation of skin and viscera in human subjects.
Topics: Adolescent; Adult; Analgesics; Analysis of Variance; Catheterization; Cross-Over Studies; Dose-Respo | 2005 |
The effects of racemic ketamine on painful stimulation of skin and viscera in human subjects.
Topics: Adolescent; Adult; Analgesics; Analysis of Variance; Catheterization; Cross-Over Studies; Dose-Respo | 2005 |
The effects of racemic ketamine on painful stimulation of skin and viscera in human subjects.
Topics: Adolescent; Adult; Analgesics; Analysis of Variance; Catheterization; Cross-Over Studies; Dose-Respo | 2005 |
The effects of racemic ketamine on painful stimulation of skin and viscera in human subjects.
Topics: Adolescent; Adult; Analgesics; Analysis of Variance; Catheterization; Cross-Over Studies; Dose-Respo | 2005 |
Intravenous ketamine sedation for painful oncology procedures.
Topics: Adolescent; Analgesics; Anesthetics, Local; Biopsy, Needle; Bone Marrow Examination; Child; Child, P | 2005 |
Comparison of ephedrine and ketamine in prevention of injection pain and hypotension due to propofol induction.
Topics: Aged; Anesthesia, Intravenous; Anesthetics, Dissociative; Anesthetics, Intravenous; Double-Blind Met | 2005 |
Ketamine pretreatment with venous occlusion attenuates pain on injection with propofol.
Topics: Adult; Anesthetics, Dissociative; Anesthetics, Intravenous; Arm; Double-Blind Method; Female; Humans | 2005 |
Preadministration of low-dose ketamine reduces tourniquet pain in healthy volunteers.
Topics: Adult; Double-Blind Method; Humans; Ketamine; Male; Middle Aged; Pain; Pain Measurement; Receptors, | 2005 |
Topical 2% amitriptyline and 1% ketamine in neuropathic pain syndromes: a randomized, double-blind, placebo-controlled trial.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Amitriptyline; Double-Blind Method; Drug Th | 2005 |
Topical 2% amitriptyline and 1% ketamine in neuropathic pain syndromes: a randomized, double-blind, placebo-controlled trial.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Amitriptyline; Double-Blind Method; Drug Th | 2005 |
Topical 2% amitriptyline and 1% ketamine in neuropathic pain syndromes: a randomized, double-blind, placebo-controlled trial.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Amitriptyline; Double-Blind Method; Drug Th | 2005 |
Topical 2% amitriptyline and 1% ketamine in neuropathic pain syndromes: a randomized, double-blind, placebo-controlled trial.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Amitriptyline; Double-Blind Method; Drug Th | 2005 |
Determining the plasma concentration of ketamine that enhances epidural bupivacaine-and-morphine-induced analgesia.
Topics: Adult; Aged; Analgesics, Opioid; Anesthesia, Epidural; Anesthetics, Dissociative; Anesthetics, Local | 2005 |
Propofol versus midazolam/ketamine for procedural sedation in pediatric oncology.
Topics: Adolescent; Anesthetics, Dissociative; Child; Child, Preschool; Conscious Sedation; Humans; Hypnotic | 2005 |
Is atropine needed with ketamine sedation? A prospective, randomised, double blind study.
Topics: Adjuvants, Anesthesia; Adolescent; Anesthetics, Dissociative; Atropine; Child; Child, Preschool; Dou | 2006 |
Differential effect of ketamine and lidocaine on spontaneous and mechanical evoked pain in patients with nerve injury pain.
Topics: Adult; Aged; Cross-Over Studies; Double-Blind Method; Female; Humans; Ketamine; Lidocaine; Male; Mid | 2006 |
Imaging pain modulation by subanesthetic S-(+)-ketamine.
Topics: Adult; Analgesics; Brain; Dose-Response Relationship, Drug; Hemodynamics; Humans; Ketamine; Magnetic | 2006 |
A randomized comparison of nitrous oxide plus hematoma block versus ketamine plus midazolam for emergency department forearm fracture reduction in children.
Topics: Adolescent; Analgesics; Analgesics, Non-Narcotic; Anesthetics, Local; Anti-Anxiety Agents; Child; Ch | 2006 |
Differential effect of intravenous S-ketamine and fentanyl on atypical odontalgia and capsaicin-evoked pain.
Topics: Adult; Analgesics; Analysis of Variance; Area Under Curve; Capsaicin; Case-Control Studies; Double-B | 2007 |
Small-dose ketamine reduces the pain of propofol injection.
Topics: Adult; Analgesics; Anesthetics, Intravenous; Double-Blind Method; Female; Humans; Injections, Intrav | 2006 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption.
Topics: Acute Disease; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap | 2007 |
A ketamine-propofol admixture does not reduce the pain on injection compared with a lidocaine-propofol admixture.
Topics: Anesthesia; Anesthetics, Intravenous; Child; Child, Preschool; Double-Blind Method; Drug Combination | 2007 |
Effect of a peripheral NMDA receptor antagonist on glutamate-evoked masseter muscle pain and mechanical sensitization in women.
Topics: Adult; Analgesics; Analysis of Variance; Contraceptives, Oral; Excitatory Amino Acid Antagonists; Fe | 2007 |
Painless injection of propofol: pretreatment with ketamine vs thiopental, meperidine, and lidocaine.
Topics: Adult; Analgesics, Opioid; Anesthetics, Dissociative; Anesthetics, Intravenous; Anesthetics, Local; | 2007 |
Painless injection of propofol: pretreatment with ketamine vs thiopental, meperidine, and lidocaine.
Topics: Adult; Analgesics, Opioid; Anesthetics, Dissociative; Anesthetics, Intravenous; Anesthetics, Local; | 2007 |
Painless injection of propofol: pretreatment with ketamine vs thiopental, meperidine, and lidocaine.
Topics: Adult; Analgesics, Opioid; Anesthetics, Dissociative; Anesthetics, Intravenous; Anesthetics, Local; | 2007 |
Painless injection of propofol: pretreatment with ketamine vs thiopental, meperidine, and lidocaine.
Topics: Adult; Analgesics, Opioid; Anesthetics, Dissociative; Anesthetics, Intravenous; Anesthetics, Local; | 2007 |
Propofol-ketamine vs propofol-fentanyl combinations for deep sedation and analgesia in pediatric patients undergoing burn dressing changes.
Topics: Analgesia; Anesthetics, Dissociative; Anesthetics, Intravenous; Bandages; Blood Pressure; Burns; Chi | 2008 |
Efficacy of ketamine in anesthetic dosage for the treatment of refractory complex regional pain syndrome: an open-label phase II study.
Topics: Activities of Daily Living; Adolescent; Anesthetics, Dissociative; Complex Regional Pain Syndromes; | 2008 |
Follow-up of pain processing recovery after ketamine in hyperalgesic fibromyalgia patients using brain perfusion ECD-SPECT.
Topics: Adult; Aged; Anesthetics, Dissociative; Brain; Cysteine; Female; Fibromyalgia; Follow-Up Studies; Hu | 2007 |
Chronic phantom limb pain: the effects of calcitonin, ketamine, and their combination on pain and sensory thresholds.
Topics: Analgesics; Calcitonin; Computers; Cross-Over Studies; Double-Blind Method; Drug Therapy, Combinatio | 2008 |
Effects of a low dose infusion of racemic and S-ketamine on the nociceptive withdrawal reflex in standing ponies.
Topics: Animals; Cross-Over Studies; Horses; Ketamine; Male; Pain; Reflex | 2008 |
The effect of N-methyl-D-aspartate antagonist (ketamine) on single and repeated nociceptive stimuli: a placebo-controlled experimental human study.
Topics: Analgesics; Cross-Over Studies; Double-Blind Method; Electric Stimulation; Electromyography; Evoked | 1995 |
Central nervous system effects of subdissociative doses of (S)-ketamine are related to plasma and brain concentrations measured with positron emission tomography in healthy volunteers.
Topics: Adult; Affect; Brain; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Hum | 1995 |
Central nervous system effects of subdissociative doses of (S)-ketamine are related to plasma and brain concentrations measured with positron emission tomography in healthy volunteers.
Topics: Adult; Affect; Brain; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Hum | 1995 |
Central nervous system effects of subdissociative doses of (S)-ketamine are related to plasma and brain concentrations measured with positron emission tomography in healthy volunteers.
Topics: Adult; Affect; Brain; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Hum | 1995 |
Central nervous system effects of subdissociative doses of (S)-ketamine are related to plasma and brain concentrations measured with positron emission tomography in healthy volunteers.
Topics: Adult; Affect; Brain; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Hum | 1995 |
Central nervous system effects of subdissociative doses of (S)-ketamine are related to plasma and brain concentrations measured with positron emission tomography in healthy volunteers.
Topics: Adult; Affect; Brain; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Hum | 1995 |
Central nervous system effects of subdissociative doses of (S)-ketamine are related to plasma and brain concentrations measured with positron emission tomography in healthy volunteers.
Topics: Adult; Affect; Brain; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Hum | 1995 |
Central nervous system effects of subdissociative doses of (S)-ketamine are related to plasma and brain concentrations measured with positron emission tomography in healthy volunteers.
Topics: Adult; Affect; Brain; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Hum | 1995 |
Central nervous system effects of subdissociative doses of (S)-ketamine are related to plasma and brain concentrations measured with positron emission tomography in healthy volunteers.
Topics: Adult; Affect; Brain; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Hum | 1995 |
Central nervous system effects of subdissociative doses of (S)-ketamine are related to plasma and brain concentrations measured with positron emission tomography in healthy volunteers.
Topics: Adult; Affect; Brain; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Hum | 1995 |
Conscious sedation by rectal administration of midazolam or midazolam plus ketamine as alternatives to general anesthesia for dental treatment of uncooperative children.
Topics: Anesthesia, Dental; Anesthesia, Local; Anesthesia, Rectal; Behavior Therapy; Child; Child Behavior; | 1994 |
The influence of adenosine, ketamine, and morphine on experimentally induced ischemic pain in healthy volunteers.
Topics: Adenosine; Adult; Drug Interactions; Drug Therapy, Combination; Female; Humans; Ischemia; Ketamine; | 1994 |
Response of chronic neuropathic pain syndromes to ketamine: a preliminary study.
Topics: Adult; Aged; Chronic Disease; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; | 1994 |
Central dysesthesia pain after traumatic spinal cord injury is dependent on N-methyl-D-aspartate receptor activation.
Topics: Adult; Aged; Alfentanil; Analgesics, Opioid; Double-Blind Method; Excitatory Amino Acid Antagonists; | 1995 |
Pain analysis in patients with fibromyalgia. Effects of intravenous morphine, lidocaine, and ketamine.
Topics: Adult; Analgesics, Opioid; Anesthetics, Dissociative; Anesthetics, Local; Double-Blind Method; Femal | 1995 |
Pain analysis in patients with fibromyalgia. Effects of intravenous morphine, lidocaine, and ketamine.
Topics: Adult; Analgesics, Opioid; Anesthetics, Dissociative; Anesthetics, Local; Double-Blind Method; Femal | 1995 |
Pain analysis in patients with fibromyalgia. Effects of intravenous morphine, lidocaine, and ketamine.
Topics: Adult; Analgesics, Opioid; Anesthetics, Dissociative; Anesthetics, Local; Double-Blind Method; Femal | 1995 |
Pain analysis in patients with fibromyalgia. Effects of intravenous morphine, lidocaine, and ketamine.
Topics: Adult; Analgesics, Opioid; Anesthetics, Dissociative; Anesthetics, Local; Double-Blind Method; Femal | 1995 |
Effects of intravenous ketamine, alfentanil, or placebo on pain, pinprick hyperalgesia, and allodynia produced by intradermal capsaicin in human subjects.
Topics: Adult; Alfentanil; Analgesics; Anesthetics, Intravenous; Capsaicin; Cross-Over Studies; Double-Blind | 1995 |
Intravenous infusion of the NMDA antagonist, ketamine, in chronic posttraumatic pain with allodynia: a double-blind comparison to alfentanil and placebo.
Topics: Adult; Alfentanil; Double-Blind Method; Female; Humans; Infusions, Intravenous; Ketamine; Middle Age | 1995 |
Analgesia for acute musculoskeletal trauma: low-dose subcutaneous infusion of ketamine.
Topics: Adult; Analgesia; Double-Blind Method; Female; Humans; Infusions, Parenteral; Ketamine; Male; Morphi | 1996 |
Analgesia for acute musculoskeletal trauma: low-dose subcutaneous infusion of ketamine.
Topics: Adult; Analgesia; Double-Blind Method; Female; Humans; Infusions, Parenteral; Ketamine; Male; Morphi | 1996 |
Analgesia for acute musculoskeletal trauma: low-dose subcutaneous infusion of ketamine.
Topics: Adult; Analgesia; Double-Blind Method; Female; Humans; Infusions, Parenteral; Ketamine; Male; Morphi | 1996 |
Analgesia for acute musculoskeletal trauma: low-dose subcutaneous infusion of ketamine.
Topics: Adult; Analgesia; Double-Blind Method; Female; Humans; Infusions, Parenteral; Ketamine; Male; Morphi | 1996 |
Analgesia for acute musculoskeletal trauma: low-dose subcutaneous infusion of ketamine.
Topics: Adult; Analgesia; Double-Blind Method; Female; Humans; Infusions, Parenteral; Ketamine; Male; Morphi | 1996 |
Analgesia for acute musculoskeletal trauma: low-dose subcutaneous infusion of ketamine.
Topics: Adult; Analgesia; Double-Blind Method; Female; Humans; Infusions, Parenteral; Ketamine; Male; Morphi | 1996 |
Analgesia for acute musculoskeletal trauma: low-dose subcutaneous infusion of ketamine.
Topics: Adult; Analgesia; Double-Blind Method; Female; Humans; Infusions, Parenteral; Ketamine; Male; Morphi | 1996 |
Analgesia for acute musculoskeletal trauma: low-dose subcutaneous infusion of ketamine.
Topics: Adult; Analgesia; Double-Blind Method; Female; Humans; Infusions, Parenteral; Ketamine; Male; Morphi | 1996 |
Analgesia for acute musculoskeletal trauma: low-dose subcutaneous infusion of ketamine.
Topics: Adult; Analgesia; Double-Blind Method; Female; Humans; Infusions, Parenteral; Ketamine; Male; Morphi | 1996 |
Analgesia for acute musculoskeletal trauma: low-dose subcutaneous infusion of ketamine.
Topics: Adult; Analgesia; Double-Blind Method; Female; Humans; Infusions, Parenteral; Ketamine; Male; Morphi | 1996 |
Analgesia for acute musculoskeletal trauma: low-dose subcutaneous infusion of ketamine.
Topics: Adult; Analgesia; Double-Blind Method; Female; Humans; Infusions, Parenteral; Ketamine; Male; Morphi | 1996 |
Analgesia for acute musculoskeletal trauma: low-dose subcutaneous infusion of ketamine.
Topics: Adult; Analgesia; Double-Blind Method; Female; Humans; Infusions, Parenteral; Ketamine; Male; Morphi | 1996 |
Analgesia for acute musculoskeletal trauma: low-dose subcutaneous infusion of ketamine.
Topics: Adult; Analgesia; Double-Blind Method; Female; Humans; Infusions, Parenteral; Ketamine; Male; Morphi | 1996 |
Analgesia for acute musculoskeletal trauma: low-dose subcutaneous infusion of ketamine.
Topics: Adult; Analgesia; Double-Blind Method; Female; Humans; Infusions, Parenteral; Ketamine; Male; Morphi | 1996 |
Analgesia for acute musculoskeletal trauma: low-dose subcutaneous infusion of ketamine.
Topics: Adult; Analgesia; Double-Blind Method; Female; Humans; Infusions, Parenteral; Ketamine; Male; Morphi | 1996 |
Analgesia for acute musculoskeletal trauma: low-dose subcutaneous infusion of ketamine.
Topics: Adult; Analgesia; Double-Blind Method; Female; Humans; Infusions, Parenteral; Ketamine; Male; Morphi | 1996 |
Intrathecal ketamine reduces morphine requirements in patients with terminal cancer pain.
Topics: Adult; Aged; Analgesics, Opioid; Cross-Over Studies; Double-Blind Method; Excitatory Amino Acid Anta | 1996 |
NMDA receptor blockade in chronic neuropathic pain: a comparison of ketamine and magnesium chloride.
Topics: Adult; Aged; Anesthetics, Dissociative; Chronic Disease; Double-Blind Method; Female; Humans; Hypera | 1996 |
NMDA receptor blockade in chronic neuropathic pain: a comparison of ketamine and magnesium chloride.
Topics: Adult; Aged; Anesthetics, Dissociative; Chronic Disease; Double-Blind Method; Female; Humans; Hypera | 1996 |
NMDA receptor blockade in chronic neuropathic pain: a comparison of ketamine and magnesium chloride.
Topics: Adult; Aged; Anesthetics, Dissociative; Chronic Disease; Double-Blind Method; Female; Humans; Hypera | 1996 |
NMDA receptor blockade in chronic neuropathic pain: a comparison of ketamine and magnesium chloride.
Topics: Adult; Aged; Anesthetics, Dissociative; Chronic Disease; Double-Blind Method; Female; Humans; Hypera | 1996 |
NMDA receptor blockade in chronic neuropathic pain: a comparison of ketamine and magnesium chloride.
Topics: Adult; Aged; Anesthetics, Dissociative; Chronic Disease; Double-Blind Method; Female; Humans; Hypera | 1996 |
NMDA receptor blockade in chronic neuropathic pain: a comparison of ketamine and magnesium chloride.
Topics: Adult; Aged; Anesthetics, Dissociative; Chronic Disease; Double-Blind Method; Female; Humans; Hypera | 1996 |
NMDA receptor blockade in chronic neuropathic pain: a comparison of ketamine and magnesium chloride.
Topics: Adult; Aged; Anesthetics, Dissociative; Chronic Disease; Double-Blind Method; Female; Humans; Hypera | 1996 |
NMDA receptor blockade in chronic neuropathic pain: a comparison of ketamine and magnesium chloride.
Topics: Adult; Aged; Anesthetics, Dissociative; Chronic Disease; Double-Blind Method; Female; Humans; Hypera | 1996 |
NMDA receptor blockade in chronic neuropathic pain: a comparison of ketamine and magnesium chloride.
Topics: Adult; Aged; Anesthetics, Dissociative; Chronic Disease; Double-Blind Method; Female; Humans; Hypera | 1996 |
Effect of racemic mixture and the (S+)-isomer of ketamine on temporal and spatial summation of pain.
Topics: Adult; Anesthetics, Dissociative; Cross-Over Studies; Double-Blind Method; Electric Stimulation; Hot | 1996 |
Effect of racemic mixture and the (S+)-isomer of ketamine on temporal and spatial summation of pain.
Topics: Adult; Anesthetics, Dissociative; Cross-Over Studies; Double-Blind Method; Electric Stimulation; Hot | 1996 |
Effect of racemic mixture and the (S+)-isomer of ketamine on temporal and spatial summation of pain.
Topics: Adult; Anesthetics, Dissociative; Cross-Over Studies; Double-Blind Method; Electric Stimulation; Hot | 1996 |
Effect of racemic mixture and the (S+)-isomer of ketamine on temporal and spatial summation of pain.
Topics: Adult; Anesthetics, Dissociative; Cross-Over Studies; Double-Blind Method; Electric Stimulation; Hot | 1996 |
Effect of racemic mixture and the (S+)-isomer of ketamine on temporal and spatial summation of pain.
Topics: Adult; Anesthetics, Dissociative; Cross-Over Studies; Double-Blind Method; Electric Stimulation; Hot | 1996 |
Effect of racemic mixture and the (S+)-isomer of ketamine on temporal and spatial summation of pain.
Topics: Adult; Anesthetics, Dissociative; Cross-Over Studies; Double-Blind Method; Electric Stimulation; Hot | 1996 |
Effect of racemic mixture and the (S+)-isomer of ketamine on temporal and spatial summation of pain.
Topics: Adult; Anesthetics, Dissociative; Cross-Over Studies; Double-Blind Method; Electric Stimulation; Hot | 1996 |
Effect of racemic mixture and the (S+)-isomer of ketamine on temporal and spatial summation of pain.
Topics: Adult; Anesthetics, Dissociative; Cross-Over Studies; Double-Blind Method; Electric Stimulation; Hot | 1996 |
Effect of racemic mixture and the (S+)-isomer of ketamine on temporal and spatial summation of pain.
Topics: Adult; Anesthetics, Dissociative; Cross-Over Studies; Double-Blind Method; Electric Stimulation; Hot | 1996 |
Oral ketamine therapy in the treatment of postamputation stump pain.
Topics: Administration, Oral; Amputation Stumps; Excitatory Amino Acid Antagonists; Humans; Ketamine; Leg; M | 1997 |
Fibromyalgia--are there different mechanisms in the processing of pain? A double blind crossover comparison of analgesic drugs.
Topics: Adult; Anesthetics, Dissociative; Area Under Curve; Cross-Over Studies; Double-Blind Method; Drug Th | 1997 |
Pharmacological classification of central post-stroke pain: comparison with the results of chronic motor cortex stimulation therapy.
Topics: Adult; Aged; Analgesics, Opioid; Anesthetics; Cerebrovascular Disorders; Female; Humans; Ketamine; L | 1997 |
The effect of ketamine pretreatment on propofol injection pain in 100 women.
Topics: Adolescent; Adult; Aged; Anesthetics, Dissociative; Anesthetics, Intravenous; Double-Blind Method; F | 1998 |
Analgesic and cognitive effects of intravenous ketamine-alfentanil combinations versus either drug alone after intradermal capsaicin in normal subjects.
Topics: Adult; Alfentanil; Analgesics; Analgesics, Opioid; Anesthetics, Dissociative; Capsaicin; Cognition; | 1998 |
Peripheral analgesic effects of ketamine in acute inflammatory pain.
Topics: Administration, Cutaneous; Adult; Anesthetics, Dissociative; Double-Blind Method; Female; Humans; In | 1998 |
Peripheral analgesic effects of ketamine in acute inflammatory pain.
Topics: Administration, Cutaneous; Adult; Anesthetics, Dissociative; Double-Blind Method; Female; Humans; In | 1998 |
Peripheral analgesic effects of ketamine in acute inflammatory pain.
Topics: Administration, Cutaneous; Adult; Anesthetics, Dissociative; Double-Blind Method; Female; Humans; In | 1998 |
Peripheral analgesic effects of ketamine in acute inflammatory pain.
Topics: Administration, Cutaneous; Adult; Anesthetics, Dissociative; Double-Blind Method; Female; Humans; In | 1998 |
The analgesic effect of racemic ketamine in patients with chronic ischemic pain due to lower extremity arteriosclerosis obliterans.
Topics: Aged; Aged, 80 and over; Analgesics; Analgesics, Opioid; Arteriosclerosis Obliterans; Chromatography | 1998 |
Comparison of fentanyl/midazolam with ketamine/midazolam for pediatric orthopedic emergencies.
Topics: Adolescent; Analgesics, Opioid; Anesthetics, Dissociative; Anti-Anxiety Agents; Anxiety; Child; Chil | 1998 |
Comparison of fentanyl/midazolam with ketamine/midazolam for pediatric orthopedic emergencies.
Topics: Adolescent; Analgesics, Opioid; Anesthetics, Dissociative; Anti-Anxiety Agents; Anxiety; Child; Chil | 1998 |
Comparison of fentanyl/midazolam with ketamine/midazolam for pediatric orthopedic emergencies.
Topics: Adolescent; Analgesics, Opioid; Anesthetics, Dissociative; Anti-Anxiety Agents; Anxiety; Child; Chil | 1998 |
Comparison of fentanyl/midazolam with ketamine/midazolam for pediatric orthopedic emergencies.
Topics: Adolescent; Analgesics, Opioid; Anesthetics, Dissociative; Anti-Anxiety Agents; Anxiety; Child; Chil | 1998 |
Comparison of fentanyl/midazolam with ketamine/midazolam for pediatric orthopedic emergencies.
Topics: Adolescent; Analgesics, Opioid; Anesthetics, Dissociative; Anti-Anxiety Agents; Anxiety; Child; Chil | 1998 |
Comparison of fentanyl/midazolam with ketamine/midazolam for pediatric orthopedic emergencies.
Topics: Adolescent; Analgesics, Opioid; Anesthetics, Dissociative; Anti-Anxiety Agents; Anxiety; Child; Chil | 1998 |
Comparison of fentanyl/midazolam with ketamine/midazolam for pediatric orthopedic emergencies.
Topics: Adolescent; Analgesics, Opioid; Anesthetics, Dissociative; Anti-Anxiety Agents; Anxiety; Child; Chil | 1998 |
Comparison of fentanyl/midazolam with ketamine/midazolam for pediatric orthopedic emergencies.
Topics: Adolescent; Analgesics, Opioid; Anesthetics, Dissociative; Anti-Anxiety Agents; Anxiety; Child; Chil | 1998 |
Comparison of fentanyl/midazolam with ketamine/midazolam for pediatric orthopedic emergencies.
Topics: Adolescent; Analgesics, Opioid; Anesthetics, Dissociative; Anti-Anxiety Agents; Anxiety; Child; Chil | 1998 |
Prolonged analgesic effect of ketamine, an N-methyl-D-aspartate receptor inhibitor, in patients with chronic pain.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Chronic Disease; Cross-Over Studies; Double-Bl | 1999 |
Clinical experience with oral ketamine.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Analgesics; Chronic Disease; Female; Humans; K | 1999 |
Midazolam/ketamine sedative combination compared with fentanyl/propofol/isoflurane anaesthesia for oocyte retrieval.
Topics: Adult; Anesthesia, General; Anesthetics; Female; Fentanyl; Humans; Hypnotics and Sedatives; Isoflura | 1999 |
N of 1 randomised controlled trials of oral ketamine in patients with chronic pain.
Topics: Administration, Oral; Analgesics; Female; Humans; Ketamine; Male; Pain; Placebos | 1999 |
The effects of ketamine on the temporal summation (wind-up) of the R(III) nociceptive flexion reflex and pain in humans.
Topics: Adult; Anesthetics, Dissociative; Cross-Over Studies; Double-Blind Method; Electric Stimulation; Hum | 2000 |
Painless invasive procedures.
Topics: Administration, Oral; Analgesics; Anesthetics, Dissociative; Child; Child, Preschool; Diagnostic Tec | 1999 |
Potency of propofol, thiopentone and ketamine at various endpoints in New Zealand White rabbits.
Topics: Anesthetics, Intravenous; Animals; Central Nervous System; Ketamine; Pain; Posture; Propofol; Rabbit | 2000 |
Ketamine reduces muscle pain, temporal summation, and referred pain in fibromyalgia patients.
Topics: Adult; Anesthetics, Dissociative; Double-Blind Method; Electric Stimulation; Excitatory Amino Acid A | 2000 |
Ketamine reduces muscle pain, temporal summation, and referred pain in fibromyalgia patients.
Topics: Adult; Anesthetics, Dissociative; Double-Blind Method; Electric Stimulation; Excitatory Amino Acid A | 2000 |
Ketamine reduces muscle pain, temporal summation, and referred pain in fibromyalgia patients.
Topics: Adult; Anesthetics, Dissociative; Double-Blind Method; Electric Stimulation; Excitatory Amino Acid A | 2000 |
Ketamine reduces muscle pain, temporal summation, and referred pain in fibromyalgia patients.
Topics: Adult; Anesthetics, Dissociative; Double-Blind Method; Electric Stimulation; Excitatory Amino Acid A | 2000 |
Preinjury treatment with morphine or ketamine inhibits the development of experimentally induced secondary hyperalgesia in man.
Topics: Adult; Analgesics; Analgesics, Opioid; Burns; Cross-Over Studies; Double-Blind Method; Excitatory Am | 2000 |
Ketamine for procedural pain relief in newborn infants.
Topics: Analgesics; Blood Pressure; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Metho | 2001 |
Low dose intravenous ketamine as an analgesic: a pilot study using an experimental model of acute pain.
Topics: Acute Disease; Adult; Anesthetics, Dissociative; Double-Blind Method; Female; Humans; Infusions, Int | 2001 |
Low dose intravenous ketamine as an analgesic: a pilot study using an experimental model of acute pain.
Topics: Acute Disease; Adult; Anesthetics, Dissociative; Double-Blind Method; Female; Humans; Infusions, Int | 2001 |
Low dose intravenous ketamine as an analgesic: a pilot study using an experimental model of acute pain.
Topics: Acute Disease; Adult; Anesthetics, Dissociative; Double-Blind Method; Female; Humans; Infusions, Int | 2001 |
Low dose intravenous ketamine as an analgesic: a pilot study using an experimental model of acute pain.
Topics: Acute Disease; Adult; Anesthetics, Dissociative; Double-Blind Method; Female; Humans; Infusions, Int | 2001 |
Low dose intravenous ketamine as an analgesic: a pilot study using an experimental model of acute pain.
Topics: Acute Disease; Adult; Anesthetics, Dissociative; Double-Blind Method; Female; Humans; Infusions, Int | 2001 |
Low dose intravenous ketamine as an analgesic: a pilot study using an experimental model of acute pain.
Topics: Acute Disease; Adult; Anesthetics, Dissociative; Double-Blind Method; Female; Humans; Infusions, Int | 2001 |
Low dose intravenous ketamine as an analgesic: a pilot study using an experimental model of acute pain.
Topics: Acute Disease; Adult; Anesthetics, Dissociative; Double-Blind Method; Female; Humans; Infusions, Int | 2001 |
Low dose intravenous ketamine as an analgesic: a pilot study using an experimental model of acute pain.
Topics: Acute Disease; Adult; Anesthetics, Dissociative; Double-Blind Method; Female; Humans; Infusions, Int | 2001 |
Low dose intravenous ketamine as an analgesic: a pilot study using an experimental model of acute pain.
Topics: Acute Disease; Adult; Anesthetics, Dissociative; Double-Blind Method; Female; Humans; Infusions, Int | 2001 |
Low dose intravenous ketamine as an analgesic: a pilot study using an experimental model of acute pain.
Topics: Acute Disease; Adult; Anesthetics, Dissociative; Double-Blind Method; Female; Humans; Infusions, Int | 2001 |
Low dose intravenous ketamine as an analgesic: a pilot study using an experimental model of acute pain.
Topics: Acute Disease; Adult; Anesthetics, Dissociative; Double-Blind Method; Female; Humans; Infusions, Int | 2001 |
Low dose intravenous ketamine as an analgesic: a pilot study using an experimental model of acute pain.
Topics: Acute Disease; Adult; Anesthetics, Dissociative; Double-Blind Method; Female; Humans; Infusions, Int | 2001 |
Low dose intravenous ketamine as an analgesic: a pilot study using an experimental model of acute pain.
Topics: Acute Disease; Adult; Anesthetics, Dissociative; Double-Blind Method; Female; Humans; Infusions, Int | 2001 |
Low dose intravenous ketamine as an analgesic: a pilot study using an experimental model of acute pain.
Topics: Acute Disease; Adult; Anesthetics, Dissociative; Double-Blind Method; Female; Humans; Infusions, Int | 2001 |
Low dose intravenous ketamine as an analgesic: a pilot study using an experimental model of acute pain.
Topics: Acute Disease; Adult; Anesthetics, Dissociative; Double-Blind Method; Female; Humans; Infusions, Int | 2001 |
Low dose intravenous ketamine as an analgesic: a pilot study using an experimental model of acute pain.
Topics: Acute Disease; Adult; Anesthetics, Dissociative; Double-Blind Method; Female; Humans; Infusions, Int | 2001 |
[Pre-treatment with ketamine reduces incidence and severity of pain on propofol injection].
Topics: Adult; Aged; Anesthesia, General; Double-Blind Method; Female; Humans; Injections, Intravenous; Keta | 2002 |
On effects of ketamine to axillary block in hand surgery.
Topics: Adult; Anesthetics, Local; Brachial Plexus; Carticaine; Drug Combinations; Hand; Humans; Ketamine; M | 2002 |
A single infusion of intravenous ketamine improves pain relief in patients with critical limb ischaemia: results of a double blind randomised controlled trial.
Topics: Aged; Analgesics; Analgesics, Opioid; Anxiety; Depression; Double-Blind Method; Extremities; Female; | 2002 |
Assessment of the effect of dextromethorphan and ketamine on the acute nociceptive threshold and wind-up of the second pain response in healthy male volunteers.
Topics: Acute Disease; Adult; Analgesics; Cross-Over Studies; Dextromethorphan; Dextrorphan; Dose-Response R | 2002 |
Comparison of ketamine and pethidine in experimental and postoperative pain.
Topics: Adult; Female; Humans; Ischemia; Ketamine; Meperidine; Naloxone; Pain; Pain, Postoperative; Visual P | 1989 |
[Intravenous analgesia with ketamine for emergency patients].
Topics: Adolescent; Adult; Aged; Emergencies; Female; Humans; Injections, Intravenous; Ketamine; Male; Middl | 1987 |
Other Studies
345 other studies available for ketamine and Ache
| Article | Year |
|---|---|
The authors respond: Topical ketamine for reducing venipuncture pain.
Topics: Administration, Topical; Humans; Ketamine; Pain; Pain Measurement; Phlebotomy | 2022 |
Topical ketamine for reducing venipuncture pain.
Topics: Administration, Topical; Humans; Ketamine; Pain; Pain Measurement; Phlebotomy | 2022 |
Role of Ketamine and Opioid Rotation in the Management of Opioid Induced Hyperalgesia in a Patient With Acute Promyelocytic Leukemia.
Topics: Adult; Analgesics, Opioid; Cancer Pain; Female; Humans; Hyperalgesia; Ketamine; Leukemia, Promyelocy | 2022 |
Paraphimosis Pain Treatment with Nebulized Ketamine in the Emergency Department.
Topics: Acute Disease; Adolescent; Analgesics; Anesthetics, Dissociative; Child; Emergency Service, Hospital | 2022 |
A dose-escalation clinical trial of intranasal ketamine for uncontrolled cancer-related pain.
Topics: Adult; Analgesics; Analgesics, Opioid; Cancer Pain; Double-Blind Method; Humans; Ketamine; Neoplasms | 2022 |
Ketamine Psychedelic and Antinociceptive Effects Are Connected.
Topics: Analgesia; Analgesics; Hallucinogens; Humans; Ketamine; Male; Pain | 2022 |
Ketamine-precipitated syndrome of inappropriate antidiuretic hormone secretion in a patient with persistent lumbar pain: a case report.
Topics: Drug-Related Side Effects and Adverse Reactions; Humans; Hyponatremia; Inappropriate ADH Syndrome; K | 2022 |
Ketamine Analgesia and Psychedelia: Can We Dissociate Dissociation?
Topics: Analgesia; Humans; Ketamine; Pain; Pain Management | 2022 |
Ketamine vs fentanyl for ED treatment of pain.
Topics: Analgesics; Analgesics, Opioid; Double-Blind Method; Fentanyl; Humans; Ketamine; Pain | 2022 |
Adjuvant low-dose ketamine for paediatric and young adult sickle cell vaso-occlusive episodes in the emergency department.
Topics: Anemia, Sickle Cell; Child; Emergency Service, Hospital; Erythrocytes, Abnormal; Humans; Ketamine; P | 2022 |
Intravenous Ketamine Infusion as an Adjunctive Pain Treatment for Erythromelalgia: A Pediatric Case Report.
Topics: Analgesics; Child; Erythromelalgia; Female; Humans; Ketamine; Pain; Pain Management | 2022 |
Prospective association of psychological pain and hopelessness with suicidal thoughts.
Topics: Depressive Disorder, Major; Depressive Disorder, Treatment-Resistant; Humans; Ketamine; Pain; Suicid | 2022 |
Procedural Sedation With Dexmedetomidine in Combination With Ketamine in the Emergency Department.
Topics: Anesthetics, Dissociative; Conscious Sedation; Dexmedetomidine; Drug Combinations; Emergency Service | 2022 |
Opioid sparing effect of ketamine in military prehospital pain management-A retrospective study.
Topics: Analgesics; Analgesics, Opioid; Emergency Medical Services; Humans; Ketamine; Military Personnel; Pa | 2022 |
Battlefield pain summit 2022: Expert consensus statements.
Topics: Analgesics; Analgesics, Non-Narcotic; Humans; Ketamine; Military Medicine; Pain; Pain Management | 2022 |
Role of intraoperative ketamine in preventing severe rebound pain for patients undergoing ambulatory upper extremity surgery. Comment on Br J Anaesth 2022; 128: 734-41.
Topics: Humans; Ketamine; Nerve Block; Pain; Pain Management; Upper Extremity | 2022 |
The N-methyl-D-aspartate receptor antagonist ketamin exerts analgesic effects via modulation of the nitric oxide pathway.
Topics: Analgesics; Animals; Ketamine; Mice; Nitric Oxide; Nitric Oxide Synthase; Pain; Receptors, N-Methyl- | 2022 |
Nebulized Ketamine for Analgesia in the Prehospital Setting: A Case Series.
Topics: Analgesia; Analgesics; Emergency Medical Services; Humans; Ketamine; Pain; Pain Management | 2023 |
Novel uses of ketamine in the emergency department.
Topics: Analgesics, Opioid; Drug Tolerance; Emergency Service, Hospital; Humans; Ketamine; Morphine; Pain | 2022 |
Effect of sedation using Ketamine for primary closure of pediatric facial laceration.
Topics: Child; Conscious Sedation; Facial Injuries; Humans; Hypnotics and Sedatives; Infant; Ketamine; Lacer | 2022 |
A subclinical dose of esketamine pretreatment for propofol and rocuronium injection pain.
Topics: Humans; Ketamine; Pain; Propofol; Rocuronium | 2022 |
Suspected opioid-induced hyperalgesia in an infant following surgery: A case report.
Topics: Adult; Analgesics, Opioid; Fentanyl; Humans; Hyperalgesia; Infant; Ketamine; Male; Pain | 2022 |
Ketamine in Total Joint Arthroplasty: The Clinical Practice Guidelines of the American Association of Hip and Knee Surgeons, American Society of Regional Anesthesia and Pain Medicine, American Academy of Orthopaedic Surgeons, Hip Society, and Knee Society
Topics: Analgesics; Anesthesia, Conduction; Arthroplasty; Arthroplasty, Replacement, Hip; Humans; Ketamine; | 2022 |
Effective anesthetic management with remimazolam and ketamine without muscle relaxants for parotidectomy in a patient with myotonic dystrophy: A case report.
Topics: Adult; Anesthetics, Intravenous; Benzodiazepines; Humans; Ketamine; Male; Muscles; Myotonic Dystroph | 2022 |
Safety and Efficacy of Propofol- and Ketamine-Based Procedural Sedation Regimen in Pediatric Patients During Burn Repetitive Dressing Change: 10 Years Single Center Experience.
Topics: Bandages; Burns; Child; Child, Preschool; Humans; Hypnotics and Sedatives; Ketamine; Pain; Propofol; | 2023 |
Sympathetic Blocks as a Predictor for Response to Ketamine Infusion in Patients with Complex Regional Pain Syndrome: A Multicenter Study.
Topics: Autonomic Nerve Block; Complex Regional Pain Syndromes; Humans; Ketamine; Pain; Reflex Sympathetic D | 2023 |
Ketamine in Severe Leptomeningeal Pain.
Topics: Analgesics; Analgesics, Opioid; Humans; Ketamine; Meningeal Carcinomatosis; Pain | 2023 |
Pre-hospital analgesia in pediatric trauma and critically ill patients: An analysis of a German air rescue service.
Topics: Analgesia; Analgesics; Analgesics, Opioid; Child; Critical Illness; Emergency Medical Services; Fent | 2023 |
Treating Prehospital Pain in Children: A Retrospective Chart Review Comparing the Safety and Efficacy of Prehospital Pediatric Ketamine and Opioid Analgesia.
Topics: Adolescent; Aged, 80 and over; Analgesia; Analgesics; Analgesics, Opioid; Child; Emergency Medical S | 2023 |
Combat Casualties Treated With Intranasal Ketamine for Prehospital Analgesia: A Case Series.
Topics: Analgesia; Analgesics; Emergency Medical Services; Humans; Ketamine; Military Medicine; Pain; Pain M | 2023 |
Ketamine use for management of vaso-occlusive pain in pediatric sickle cell disease.
Topics: Adolescent; Analgesics, Opioid; Anemia, Sickle Cell; Child; Humans; Ketamine; Pain; Retrospective St | 2023 |
The intranasal route for ketamine administration may be a simple way to improve battlefield analgesia.
Topics: Analgesia; Analgesics; Humans; Ketamine; Pain; Pain Management | 2023 |
Prospective observational study on the use of continuous intravenous ketamine and propofol infusion for prolonged sedation in critical care.
Topics: Child; Cohort Studies; Critical Care; Humans; Hypnotics and Sedatives; Ketamine; Pain; Propofol; Pro | 2023 |
Routine Prophylactic Esketamine for the Prevention of Maternal Pain During Cesarean Delivery.
Topics: Cesarean Section; Female; Humans; Ketamine; Pain; Pregnancy | 2023 |
Ketamine infusion for pain management in hospitalized patients with Chronic Pancreatitis: A case series.
Topics: Analgesics; Chronic Pain; Humans; Infusions, Intravenous; Ketamine; Pain; Pain Management; Pancreati | 2023 |
Expanded indications of ketamine infusions for pediatric non-surgical pain: a 10 year, single-center experience.
Topics: Analgesics; Child; Humans; Infusions, Intravenous; Ketamine; Pain | 2023 |
Pain mediates the improvement of social functions of repeated intravenous ketamine in patients with unipolar and bipolar depression.
Topics: Bipolar Disorder; Depression; Depressive Disorder; Depressive Disorder, Treatment-Resistant; Humans; | 2023 |
Exploring the role of mu opioid receptors in the therapeutic potential and abuse liability of (S)-ketamine.
Topics: Analgesics, Opioid; Humans; Ketamine; Pain; Receptors, Opioid, mu | 2024 |
Comment on: Ketamine use for management of vaso-occlusive pain in pediatric sickle cell disease.
Topics: Analgesics; Anemia, Sickle Cell; Child; Humans; Ketamine; Pain | 2023 |
Race and Ethnicity and Prehospital Use of Opioid or Ketamine Analgesia in Acute Traumatic Injury.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; American Indian or Alaska Native; Analgesia; Analgesics, | 2023 |
The potent analgesia of intrathecal 2R, 6R-HNK via TRPA1 inhibition in LF-PENS-induced chronic primary pain model.
Topics: Analgesics; Animals; Calcitonin Gene-Related Peptide; Calcium; Ketamine; Mice; Pain; Transcutaneous | 2023 |
Reply to: Comment on: Ketamine use for management of vaso-occlusive pain in pediatric sickle cell disease.
Topics: Analgesics; Anemia, Sickle Cell; Child; Humans; Ketamine; Pain | 2024 |
Ketamine: Safe Until It's Not - A Terrifying Trip to the K-Hole.
Topics: Emergency Medicine; Humans; Hypnotics and Sedatives; Ketamine; Pain; Pain Management | 2019 |
Involvement of serotonergic and opioidergic systems in the antinociceptive effect of ketamine-magnesium sulphate combination in formalin test in rats.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Drug Therapy, Combination; Formaldehyde; Keta | 2019 |
Is Intranasal Ketamine Safe and Effective as a Prehospital Analgesic?
Topics: Adult; Analgesia; Analgesics; Double-Blind Method; Emergency Medical Services; Humans; Ketamine; Pai | 2020 |
Peripheral antinociception induced by ketamine is mediated by the endogenous opioid system.
Topics: Analgesics; Animals; Cinnamates; Dinoprostone; Ketamine; Male; Mice; Morphine Derivatives; Naloxone; | 2019 |
KEA-1010, a ketamine ester analogue, retains analgesic and sedative potency but is devoid of Psychomimetic effects.
Topics: Analgesics; Animals; Behavior, Animal; Esters; Female; Hypnotics and Sedatives; Ketamine; Male; Pain | 2019 |
The ketamine crisis: Does South Africa have a plan B?
Topics: Analgesics; Burns; Humans; Ketamine; Pain; South Africa | 2019 |
Analgesic efficacy of an intravenous constant rate infusion of a morphine-lidocaine-ketamine combination in Holstein calves undergoing umbilical herniorrhaphy.
Topics: Analgesics; Animals; Cattle; Female; Hernia, Umbilical; Herniorrhaphy; Hydrocortisone; Infusions, In | 2020 |
Ketamine Safety and Use in the Emergency Department for Pain and Agitation/Delirium: A Health System Experience.
Topics: Adult; Analgesia; Anesthetics, Dissociative; Conscious Sedation; Delirium; Emergency Service, Hospit | 2020 |
[Analgesia for trauma patients in emergency medicine].
Topics: Analgesia; Emergency Medical Services; Emergency Medicine; Fentanyl; Humans; Ketamine; Pain; Pain Ma | 2020 |
Fentanyl impairs but ketamine preserves the microcirculatory response to hemorrhage.
Topics: Administration, Topical; Analgesics; Analgesics, Opioid; Animals; Blood Pressure; Fentanyl; Heart Ra | 2020 |
Ketamine for Pain: The Dosing Dilemma and Missing Pieces.
Topics: Analgesics; Humans; Ketamine; Pain | 2021 |
Feasibility and impact of the implementation of a clinical scale-based sedation-analgesia protocol in severe burn patients undergoing mechanical ventilation. A before-after bi-center study.
Topics: Adult; Analgesics, Opioid; Burns; Clinical Protocols; Controlled Before-After Studies; Dose-Response | 2020 |
Repeated subcutaneous esketamine administration for depressive symptoms and pain relief in a terminally ill cancer patient: A case report.
Topics: Abdominal Neoplasms; Aged; Antidepressive Agents; Depression; Humans; Ketamine; Male; Pain; Terminal | 2020 |
Continuous Ketamine Infusion for Pain as an Opportunity for Psychotherapy for PTSD: A Case Series of Ketamine-Enhanced Psychotherapy for PTSD and Pain (KEP-P2).
Topics: Adult; Aged; Excitatory Amino Acid Antagonists; Female; Humans; Infusions, Intravenous; Ketamine; Ma | 2020 |
Transient amnesia following prehospital low-dose ketamine administration.
Topics: Accidental Falls; Aged; Analgesics; Anemia; Dose-Response Relationship, Drug; Emergency Medical Serv | 2020 |
Topical Ketamine and Revision of the World Health Organization Step Ladder for Cancer Pain.
Topics: Analgesics; Cancer Pain; Humans; Ketamine; Neoplasms; Pain; World Health Organization | 2020 |
Ketamine for pain control of snake envenomation in Guinea: A case series.
Topics: Adult; Animals; Antivenins; Female; Guinea; Humans; Ketamine; Male; Middle Aged; Pain; Pain Manageme | 2020 |
Intravenous Ketamine Administered as Patient Controlled Analgesia and Continuous Infusion for Central Pain Syndrome.
Topics: Analgesia, Patient-Controlled; Humans; Infusions, Intravenous; Ketamine; Male; Middle Aged; Pain; Pa | 2021 |
Antinociceptive activity of 3β-6β-16β-trihydroxylup-20 (29)-ene triterpene isolated from Combretum leprosum leaves in adult zebrafish (Danio rerio).
Topics: Acid Sensing Ion Channels; Amiloride; Analgesics; Animals; Camphor; Capsaicin; Combretum; Dose-Respo | 2020 |
Ketamine Use for Prolonged Field Care Reduces Supply Use.
Topics: Adult; Analgesia; Analgesics; Humans; Ketamine; Male; Pain; Pain Management; Wounds, Gunshot | 2020 |
Ketamine for Acute Pain Management and Sedation.
Topics: Adult; Aged; Aged, 80 and over; Analgesics; Conscious Sedation; Critical Care Nursing; Female; Human | 2020 |
Emergency procedural sedation in children.
Topics: Anesthetics, Dissociative; Antiemetics; Child; Contraindications, Drug; Emergency Service, Hospital; | 2020 |
Anesthetic Management of a Complex Regional Pain Syndrome (CRPS) Patient With Ketamine.
Topics: Anesthetics; Complex Regional Pain Syndromes; Humans; Ketamine; Pain; Reflex Sympathetic Dystrophy | 2020 |
Patient-controlled analgesia in sickle-cell disease painful vaso-occlusive crises: should we add ketamine to morphine?
Topics: Analgesia, Patient-Controlled; Anemia, Sickle Cell; Humans; Ketamine; Morphine; Pain | 2021 |
Population scale data reveals the antidepressant effects of ketamine and other therapeutics approved for non-psychiatric indications.
Topics: Adverse Drug Reaction Reporting Systems; Analgesics; Anti-Bacterial Agents; Anti-Inflammatory Agents | 2017 |
Intra-articular injections of ketamine and 25% dextrose improve clinical and pathological outcomes in the monosodium iodoacetate model of osteoarthritis.
Topics: Animals; Arthritis, Experimental; Behavior, Animal; Drug Therapy, Combination; Glucose; Hyaluronic A | 2017 |
Additive and antagonistic antinociceptive interactions between magnesium sulfate and ketamine in the rat formalin test.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Formaldehyde; Ketamine; Magnesium Sulfate; Ma | 2017 |
Why was a local anaesthetic used before administering intranasal ketamine for paediatric injuries?
Topics: Analgesics; Anesthetics, Local; Child; Humans; Ketamine; Pain; Pain Management | 2018 |
Patient characteristics affect the response to ketamine and opioids during the treatment of vaso-occlusive episode-related pain in sickle cell disease.
Topics: Adolescent; Analgesics, Opioid; Anemia, Sickle Cell; Child; Child, Preschool; Cohort Studies; Female | 2018 |
[Comment on: ketamine for prevention of postoperative delirium and pain].
Topics: Analgesics; Delirium; Humans; Ketamine; Pain; Pain, Postoperative; Postoperative Complications | 2017 |
Additive and subadditive antiallodynic interactions between μ-opioid agonists and N-methyl D-aspartate antagonists in male rhesus monkeys.
Topics: Analgesics; Analgesics, Opioid; Animals; Conditioning, Operant; Dizocilpine Maleate; Dose-Response R | 2018 |
The Involvement of the Endocannabinoid System in the Peripheral Antinociceptive Action of Ketamine.
Topics: Analgesics; Animals; Arachidonic Acids; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagoni | 2018 |
Intravenous Ketamine Relieves Pain and Depression After Traumatic Suicide Attempts: A Case Series.
Topics: Administration, Intravenous; Aged; Aged, 80 and over; Analgesics; Antidepressive Agents; Depressive | 2018 |
Ligustrazine Enhances the Hypnotic and Analgesic Effect of Ketamine in Mice.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Drug Synergism; Hypnotics and Sedatives; Inje | 2018 |
Ketamine as an Analgesic Adjuvant in Adult Trauma Intensive Care Unit Patients With Rib Fracture.
Topics: Adjuvants, Pharmaceutic; Aged; Analgesics; Female; Humans; Infusions, Intravenous; Intensive Care Un | 2018 |
Prospective follow-up of a cohort of preterm infants<33 WG receiving ketamine for tracheal intubation in the delivery room: Neurological outcome at 1 and 2 years.
Topics: Analgesics; Case-Control Studies; Child Development; Child, Preschool; Cohort Studies; Delivery Room | 2018 |
Ketamine for military prehospital analgesia and sedation in combat casualties.
Topics: Accreditation; Analgesics; Capnography; Clinical Governance; Dose-Response Relationship, Drug; Emerg | 2018 |
Continuous Intravenous Sub-Dissociative Dose Ketamine Infusion for Managing Pain in the Emergency Department.
Topics: Administration, Intravenous; Analgesics; Emergency Service, Hospital; Female; Humans; Ketamine; Male | 2018 |
Low-Dose Ketamine Infusion for Adjunct Management during Vaso-occlusive Episodes in Adults with Sickle Cell Disease: A Case Series.
Topics: Adult; Analgesics; Analgesics, Opioid; Anemia, Sickle Cell; Dose-Response Relationship, Drug; Female | 2018 |
Ketamine Use in the Intensive Care Unit.
Topics: Adult; Analgesics; Critical Care; Curriculum; Education, Nursing, Continuing; Female; Humans; Ketami | 2018 |
CE: Original Research: The Efficacy and Safety of an RN-Driven Ketamine Protocol for Adjunctive Analgesia During Burn Wound Care.
Topics: Adult; Analgesia; Analgesics; Analgesics, Opioid; Burns; Critical Care Nursing; Female; Fentanyl; Hu | 2018 |
Brain Dynamics and Temporal Summation of Pain Predicts Neuropathic Pain Relief from Ketamine Infusion.
Topics: Adult; Analgesics; Brain; Female; Humans; Infusions, Intravenous; Ketamine; Magnetic Resonance Imagi | 2018 |
Case Report: Ketamine for Pain and Depression in Advanced Cancer.
Topics: Analgesics; Depression; Humans; Ketamine; Male; Middle Aged; Neoplasms; Pain; Treatment Outcome | 2018 |
Ketamine stakes in 2018: Right doses, good choices.
Topics: Bariatric Surgery; Double-Blind Method; Humans; Ketamine; Laparoscopy; Pain | 2019 |
Targeting the affective component of pain with ketamine: A tool to improve the postoperative experience?
Topics: Analgesics; Bariatric Surgery; Double-Blind Method; Humans; Ketamine; Laparoscopy; Pain | 2019 |
Prehospital ketamine administration to pediatric trauma patients with head injuries in combat theaters.
Topics: Adolescent; Analgesia; Child; Child, Preschool; Craniocerebral Trauma; Emergency Medical Services; F | 2019 |
Letter to the Editor: Low-dose ketamine for pain control in patients with multiple rib fractures.
Topics: Adult; Humans; Ketamine; Pain; Pain Management; Rib Fractures; Spinal Fractures | 2019 |
Authors' Reply to the Letter to the Editor from Mukhdomi and Kendall.
Topics: Analgesics, Opioid; Humans; Ketamine; Pain | 2019 |
Evaluation of Tramadol-Midazolam-Ketamine Anaesthesia in Rabbits.
Topics: Anesthetics; Animals; Body Temperature; Heart Rate; Ketamine; Midazolam; Pain; Rabbits; Tramadol; Xy | 2018 |
Plasticity in the dynamic pain connectome associated with ketamine-induced neuropathic pain relief.
Topics: Adult; Aged; Algorithms; Anesthetics, Dissociative; Connectome; Female; Gyrus Cinguli; Humans; Ketam | 2019 |
Beyond Opioids for Pain Management in Adult Critically Ill Patients.
Topics: Acetaminophen; Adrenergic alpha-2 Receptor Agonists; Adult; Analgesia; Analgesics; Analgesics, Non-N | 2019 |
Comments on the paper by Nielsen et al. entitled "Intraoperative S-ketamine for the reduction of opioid consumption and pain one year after spine surgery: A randomized clinical trial of opioid-dependent patients".
Topics: Analgesics, Opioid; Humans; Ketamine; Pain | 2019 |
Reply to Letter: Ketamine infusion for pain control in adult patients with multiple rib fractures.
Topics: Adult; Humans; Ketamine; Pain; Pain Management; Rib Fractures; Spinal Fractures | 2019 |
Low-dose ketamine provides poor analgesia for pain in redback spider envenoming.
Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Female; Humans; Ketamine; Male; Middle Aged; Pain; Pilo | 2019 |
Involvement of ATP-sensitive K(+) channels in the peripheral antinociceptive effect induced by ketamine.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; KATP Channels; Ketamine; Male; Pain; Pressure | 2013 |
Effects of low-dose IV ketamine on peripheral and central pain from major limb injuries sustained in combat.
Topics: Adolescent; Adult; Analgesics, Opioid; Excitatory Amino Acid Antagonists; Extremities; Humans; Infus | 2013 |
Prehospital analgesia using nasal administration of S-ketamine--a case series.
Topics: Administration, Intranasal; Adolescent; Analgesics; Child; Emergency Medical Services; Humans; Ketam | 2013 |
Prehospital analgesia using nasal administration of S-ketamine--a case series.
Topics: Administration, Intranasal; Adolescent; Analgesics; Child; Emergency Medical Services; Humans; Ketam | 2013 |
Prehospital analgesia using nasal administration of S-ketamine--a case series.
Topics: Administration, Intranasal; Adolescent; Analgesics; Child; Emergency Medical Services; Humans; Ketam | 2013 |
Prehospital analgesia using nasal administration of S-ketamine--a case series.
Topics: Administration, Intranasal; Adolescent; Analgesics; Child; Emergency Medical Services; Humans; Ketam | 2013 |
Prehospital analgesia using nasal administration of S-ketamine--a case series.
Topics: Administration, Intranasal; Adolescent; Analgesics; Child; Emergency Medical Services; Humans; Ketam | 2013 |
Prehospital analgesia using nasal administration of S-ketamine--a case series.
Topics: Administration, Intranasal; Adolescent; Analgesics; Child; Emergency Medical Services; Humans; Ketam | 2013 |
Prehospital analgesia using nasal administration of S-ketamine--a case series.
Topics: Administration, Intranasal; Adolescent; Analgesics; Child; Emergency Medical Services; Humans; Ketam | 2013 |
Prehospital analgesia using nasal administration of S-ketamine--a case series.
Topics: Administration, Intranasal; Adolescent; Analgesics; Child; Emergency Medical Services; Humans; Ketam | 2013 |
Prehospital analgesia using nasal administration of S-ketamine--a case series.
Topics: Administration, Intranasal; Adolescent; Analgesics; Child; Emergency Medical Services; Humans; Ketam | 2013 |
The role of a low-dose ketamine-midazolam regimen in the management of severe painful crisis in patients with sickle cell disease.
Topics: Administration, Intravenous; Adolescent; Adult; Analgesics; Analgesics, Opioid; Anemia, Sickle Cell; | 2014 |
The role of a low-dose ketamine-midazolam regimen in the management of severe painful crisis in patients with sickle cell disease.
Topics: Administration, Intravenous; Adolescent; Adult; Analgesics; Analgesics, Opioid; Anemia, Sickle Cell; | 2014 |
The role of a low-dose ketamine-midazolam regimen in the management of severe painful crisis in patients with sickle cell disease.
Topics: Administration, Intravenous; Adolescent; Adult; Analgesics; Analgesics, Opioid; Anemia, Sickle Cell; | 2014 |
The role of a low-dose ketamine-midazolam regimen in the management of severe painful crisis in patients with sickle cell disease.
Topics: Administration, Intravenous; Adolescent; Adult; Analgesics; Analgesics, Opioid; Anemia, Sickle Cell; | 2014 |
[Effect of subanaesthetic dose of ketamine on mechanical stimulus on brain regions].
Topics: Adult; Analgesics; Brain; Humans; Ketamine; Magnetic Resonance Imaging; Male; Pain; Pilot Projects | 2013 |
Sickle cell pain management: are we missing the role of pronociception and neuropathic pain?
Topics: Anemia, Sickle Cell; Anesthetics, Dissociative; Arterial Occlusive Diseases; Excitatory Amino Acid A | 2013 |
Subanalgesic ketamine enhances morphine-induced antinociceptive activity without cortical dysfunction in rats.
Topics: Analgesics; Animals; Cerebellar Cortex; Dose-Response Relationship, Drug; Ketamine; Male; Morphine; | 2014 |
Ultra-low-dose ketamine infusion for ischemic limb pain.
Topics: Adult; Analgesics; Dose-Response Relationship, Drug; Humans; Ischemia; Ketamine; Leg; Male; Pain; Tr | 2014 |
Influence of clonidine and ketamine on m-RNA expression in a model of opioid-induced hyperalgesia in mice.
Topics: Analgesics, Opioid; Animals; Arrestins; beta-Arrestin 2; beta-Arrestins; Brain; Clonidine; Disease M | 2013 |
[Ketamine-induced urinary symptoms].
Topics: Adult; Analgesics; Hallucinogens; Hematuria; Humans; Illicit Drugs; Ketamine; Lower Urinary Tract Sy | 2014 |
Sub-dissociative-dose intranasal ketamine for moderate to severe pain in adult emergency department patients.
Topics: Administration, Intranasal; Adult; Anesthetics, Dissociative; Dose-Response Relationship, Drug; Emer | 2014 |
Sub-dissociative-dose intranasal ketamine for moderate to severe pain in adult emergency department patients.
Topics: Administration, Intranasal; Adult; Anesthetics, Dissociative; Dose-Response Relationship, Drug; Emer | 2014 |
Sub-dissociative-dose intranasal ketamine for moderate to severe pain in adult emergency department patients.
Topics: Administration, Intranasal; Adult; Anesthetics, Dissociative; Dose-Response Relationship, Drug; Emer | 2014 |
Sub-dissociative-dose intranasal ketamine for moderate to severe pain in adult emergency department patients.
Topics: Administration, Intranasal; Adult; Anesthetics, Dissociative; Dose-Response Relationship, Drug; Emer | 2014 |
Sub-dissociative-dose intranasal ketamine for moderate to severe pain in adult emergency department patients.
Topics: Administration, Intranasal; Adult; Anesthetics, Dissociative; Dose-Response Relationship, Drug; Emer | 2014 |
Sub-dissociative-dose intranasal ketamine for moderate to severe pain in adult emergency department patients.
Topics: Administration, Intranasal; Adult; Anesthetics, Dissociative; Dose-Response Relationship, Drug; Emer | 2014 |
Sub-dissociative-dose intranasal ketamine for moderate to severe pain in adult emergency department patients.
Topics: Administration, Intranasal; Adult; Anesthetics, Dissociative; Dose-Response Relationship, Drug; Emer | 2014 |
Sub-dissociative-dose intranasal ketamine for moderate to severe pain in adult emergency department patients.
Topics: Administration, Intranasal; Adult; Anesthetics, Dissociative; Dose-Response Relationship, Drug; Emer | 2014 |
Sub-dissociative-dose intranasal ketamine for moderate to severe pain in adult emergency department patients.
Topics: Administration, Intranasal; Adult; Anesthetics, Dissociative; Dose-Response Relationship, Drug; Emer | 2014 |
Sub-dissociative-dose intranasal ketamine for moderate to severe pain in adult emergency department patients.
Topics: Administration, Intranasal; Adult; Anesthetics, Dissociative; Dose-Response Relationship, Drug; Emer | 2014 |
Sub-dissociative-dose intranasal ketamine for moderate to severe pain in adult emergency department patients.
Topics: Administration, Intranasal; Adult; Anesthetics, Dissociative; Dose-Response Relationship, Drug; Emer | 2014 |
Sub-dissociative-dose intranasal ketamine for moderate to severe pain in adult emergency department patients.
Topics: Administration, Intranasal; Adult; Anesthetics, Dissociative; Dose-Response Relationship, Drug; Emer | 2014 |
Sub-dissociative-dose intranasal ketamine for moderate to severe pain in adult emergency department patients.
Topics: Administration, Intranasal; Adult; Anesthetics, Dissociative; Dose-Response Relationship, Drug; Emer | 2014 |
Sub-dissociative-dose intranasal ketamine for moderate to severe pain in adult emergency department patients.
Topics: Administration, Intranasal; Adult; Anesthetics, Dissociative; Dose-Response Relationship, Drug; Emer | 2014 |
Sub-dissociative-dose intranasal ketamine for moderate to severe pain in adult emergency department patients.
Topics: Administration, Intranasal; Adult; Anesthetics, Dissociative; Dose-Response Relationship, Drug; Emer | 2014 |
Sub-dissociative-dose intranasal ketamine for moderate to severe pain in adult emergency department patients.
Topics: Administration, Intranasal; Adult; Anesthetics, Dissociative; Dose-Response Relationship, Drug; Emer | 2014 |
Prehospital use of ketamine for analgesia and procedural sedation by critical care paramedics in the UK: a note of caution?
Topics: Allied Health Personnel; Analgesia; Conscious Sedation; Critical Care; Emergency Medical Services; H | 2014 |
[Is it acceptable in 2014 that three-quarters of newborns are intubated without any sedation in the delivery room?].
Topics: Analgesics; Delivery Rooms; Delivery, Obstetric; Humans; Hypnotics and Sedatives; Infant, Newborn; I | 2014 |
Psychiatric side effects of ketamine in hospitalized medical patients administered subanesthetic doses for pain control.
Topics: Adolescent; Adult; Aged; Analgesics; Female; Hospitalization; Humans; Ketamine; Male; Middle Aged; P | 2014 |
Prepubertal gonadectomy in cats: different injectable anaesthetic combinations and comparison with gonadectomy at traditional age.
Topics: Anesthesia; Anesthetics; Animals; Buprenorphine; Cats; Dexmedetomidine; Female; Injections, Intramus | 2015 |
Ketamine coadministration attenuates morphine tolerance and leads to increased brain concentrations of both drugs in the rat.
Topics: Analgesics; Analgesics, Opioid; Animals; Behavior, Animal; Brain; Chromatography, High Pressure Liqu | 2015 |
Low-Dose Ketamine Infusion for Emergency Department Patients with Severe Pain.
Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Blood Pressure; Dizziness; Dose-Response Relationship, | 2015 |
Low-Dose Ketamine Infusion for Emergency Department Patients with Severe Pain.
Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Blood Pressure; Dizziness; Dose-Response Relationship, | 2015 |
Low-Dose Ketamine Infusion for Emergency Department Patients with Severe Pain.
Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Blood Pressure; Dizziness; Dose-Response Relationship, | 2015 |
Low-Dose Ketamine Infusion for Emergency Department Patients with Severe Pain.
Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Blood Pressure; Dizziness; Dose-Response Relationship, | 2015 |
Low-Dose Ketamine Infusion for Emergency Department Patients with Severe Pain.
Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Blood Pressure; Dizziness; Dose-Response Relationship, | 2015 |
Low-Dose Ketamine Infusion for Emergency Department Patients with Severe Pain.
Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Blood Pressure; Dizziness; Dose-Response Relationship, | 2015 |
Low-Dose Ketamine Infusion for Emergency Department Patients with Severe Pain.
Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Blood Pressure; Dizziness; Dose-Response Relationship, | 2015 |
Low-Dose Ketamine Infusion for Emergency Department Patients with Severe Pain.
Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Blood Pressure; Dizziness; Dose-Response Relationship, | 2015 |
Low-Dose Ketamine Infusion for Emergency Department Patients with Severe Pain.
Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Blood Pressure; Dizziness; Dose-Response Relationship, | 2015 |
Low-Dose Ketamine Infusion for Emergency Department Patients with Severe Pain.
Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Blood Pressure; Dizziness; Dose-Response Relationship, | 2015 |
Low-Dose Ketamine Infusion for Emergency Department Patients with Severe Pain.
Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Blood Pressure; Dizziness; Dose-Response Relationship, | 2015 |
Low-Dose Ketamine Infusion for Emergency Department Patients with Severe Pain.
Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Blood Pressure; Dizziness; Dose-Response Relationship, | 2015 |
Low-Dose Ketamine Infusion for Emergency Department Patients with Severe Pain.
Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Blood Pressure; Dizziness; Dose-Response Relationship, | 2015 |
Low-Dose Ketamine Infusion for Emergency Department Patients with Severe Pain.
Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Blood Pressure; Dizziness; Dose-Response Relationship, | 2015 |
Low-Dose Ketamine Infusion for Emergency Department Patients with Severe Pain.
Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Blood Pressure; Dizziness; Dose-Response Relationship, | 2015 |
Low-Dose Ketamine Infusion for Emergency Department Patients with Severe Pain.
Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Blood Pressure; Dizziness; Dose-Response Relationship, | 2015 |
The Efficacy and Safety of Procedural Sedoanalgesia with Midazolam and Ketamine in Pediatric Hematology.
Topics: Adolescent; Analgesia; Analgesics; Bone Marrow Examination; Child; Child, Preschool; Deep Sedation; | 2015 |
Novel polymeric bioerodable microparticles for prolonged-release intrathecal delivery of analgesic agents for relief of intractable cancer-related pain.
Topics: Analgesics; Analgesics, Opioid; Animals; Delayed-Action Preparations; Ketamine; Lactic Acid; Male; M | 2015 |
Low-Dose Ketamine in Chronic Critical Illness.
Topics: Analgesics; Anxiety; Chronic Disease; Critical Care; Critical Illness; Dose-Response Relationship, D | 2016 |
A synergistic interaction between magnesium sulphate and ketamine on the inhibition of acute nociception in rats.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Ke | 2015 |
Comparison of two treatments with skewed ordinal responses.
Topics: Analgesics; Biostatistics; Computer Simulation; Humans; Ketamine; Logistic Models; Models, Statistic | 2016 |
Evaluation of the Percutaneous Absorption of Ketamine HCl, Gabapentin, Clonidine HCl, and Baclofen, in Compounded Transdermal Pain Formulations, Using the Franz Finite Dose Model.
Topics: Administration, Cutaneous; Aged; Amines; Baclofen; Clonidine; Cyclohexanecarboxylic Acids; Drug Comp | 2016 |
Combination of paracetamol or ketamine with meperidine enhances antinociception.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Dose-Response Relationship, Dr | 2016 |
Ketamine for pain management in France, an observational survey.
Topics: Acute Pain; Aged; Anesthetics, Dissociative; Chronic Pain; Female; France; Health Care Surveys; Huma | 2015 |
Pharmacological effects and toxicity of Costus pulverulentus C. Presl (Costaceae).
Topics: Acetic Acid; Analgesics; Anesthetics, Dissociative; Animals; Anti-Inflammatory Agents; Cell Line, Tu | 2016 |
Effects of the noncompetitive N-methyl-d-aspartate receptor antagonists ketamine and MK-801 on pain-stimulated and pain-depressed behaviour in rats.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Dizocilpine Maleate; Excitatory Amino Acid Antago | 2016 |
Importance of Pharmacological Evaluation in the Treatment of Poststroke Pain by Spinal Cord Stimulation.
Topics: Adult; Aged; Analgesics; Female; Humans; Ketamine; Male; Middle Aged; Morphine; Pain; Pain Managemen | 2016 |
A two-year retrospective review of the determinants of pre-hospital analgesia administration by alpine helicopter emergency medical physicians to patients with isolated limb injury.
Topics: Adult; Air Ambulances; Analgesia; Analgesics; Analgesics, Opioid; Emergency Medical Services; Female | 2016 |
[Safety and efficacy of ketamine for pain relief].
Topics: Analgesics; Humans; Infusions, Intravenous; Ketamine; Pain; Pain Management | 2016 |
The Role of Immunoglobulin E in the Pathogenesis of Ketamine Related Cystitis and Ulcerative Interstitial Cystitis: An Immunohistochemical Study.
Topics: Adult; Aged; Biomarkers; Cystitis, Interstitial; Female; Humans; Immunoglobulin E; Ketamine; Male; M | 2016 |
Will a Japanese Intravenous Ketamine-Resistant Patient Lose a Chance to Undergo the Spinal Cord Stimulation in the Future? Problems of Drug Challenge Test.
Topics: Analgesics; Humans; Japan; Ketamine; Pain; Pain Management; Pain Measurement; Spinal Cord Stimulatio | 2016 |
Effectiveness of ketamine as an adjuvant to opioid-based therapy in decreasing pain associated with opioid tolerance in adults undergoing orthopedic surgery: a systematic review protocol.
Topics: Adolescent; Adult; Aged; Analgesics; Analgesics, Opioid; Chemotherapy, Adjuvant; Drug Tolerance; Hum | 2016 |
Pain management for chemotherapy-induced oral mucositis.
Topics: Administration, Intravenous; Analgesics; Analgesics, Opioid; Antineoplastic Agents; Cancer Pain; Chi | 2016 |
Alternative analgesics: New drugs for pain seek to improve on ketamine's benefits.
Topics: Analgesics, Non-Narcotic; Animals; Complex Regional Pain Syndromes; Drug Design; Fractures, Bone; Hu | 2017 |
A Case Report: Subanesthetic Ketamine Infusion for Treatment of Cancer-Related Pain Produces Urinary Urge Incontinence.
Topics: Analgesics; Female; Humans; Infusions, Intravenous; Ketamine; Neoplasms; Pain; Pain Measurement; Uri | 2017 |
Alterations in haemodynamic parameters during procedural sedation and analgesia in children: Is ketamine really to blame?
Topics: Analgesia; Anesthetics, Dissociative; Child; Emergency Service, Hospital; Hemodynamics; Humans; Hypn | 2018 |
Interaction between morphine and norketamine enantiomers in rodent models of nociception.
Topics: Analgesics, Opioid; Animals; Constriction, Pathologic; Dose-Response Relationship, Drug; Drug Combin | 2008 |
Effects of norketamine enantiomers in rodent models of persistent pain.
Topics: Animals; Behavior, Animal; Chronic Disease; Constriction, Pathologic; Dose-Response Relationship, Dr | 2008 |
Plasma levels of a low-dose constant-rate-infusion of ketamine and its effect on single and repeated nociceptive stimuli in conscious dogs.
Topics: Anesthetics, Dissociative; Animals; Dogs; Dose-Response Relationship, Drug; Electromyography; Infusi | 2009 |
An intravenous ketamine test as a predictive response tool in opioid-exposed patients with persistent pain.
Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Anesthetics, Dissociative; Chronic Disease; Fema | 2009 |
Haloperidol and risperidone have specific effects on altered pain sensitivity in the ketamine model of schizophrenia.
Topics: Analgesics, Opioid; Animals; Antipsychotic Agents; Dose-Response Relationship, Drug; Electric Stimul | 2009 |
Prevention of N-methyl-D-aspartate-induced mechanical nociception by intrathecal administration of ketoprofen and ketamine in sheep.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Female; Injections, Spinal; Ketamine; Ketoprofen; | 2008 |
Adding midazolam to ketamine in the pediatric emergency department--it doesn't add up.
Topics: Anesthetics, Dissociative; Anesthetics, Intravenous; Drug Therapy, Combination; Emergency Medical Se | 2008 |
European pain management discussion forum.
Topics: Analgesics; Analgesics, Opioid; Botulinum Toxins, Type A; Drug Tolerance; Humans; Ketamine; Neuromus | 2008 |
Effective use of topical amitriptyline hydrochloride 2.5% and ketamine hydrochloride 0.5% for analgesia in refractory proctodynia.
Topics: Administration, Topical; Amitriptyline; Anal Canal; Analgesics; Drug Combinations; Humans; Ketamine; | 2008 |
Dreaming of patients' satisfaction.
Topics: Anesthetics, Dissociative; Humans; Ketamine; Pain; Pain Measurement; Pain, Postoperative; Patient Sa | 2009 |
Pharmacokinetics of ketamine and its metabolite norketamine administered at a sub-anesthetic dose together with xylazine to calves prior to castration.
Topics: Adrenergic alpha-Agonists; Anesthesia, Intravenous; Anesthetics, Dissociative; Animals; Cattle; Chro | 2009 |
Antinociceptive effect of the cannabinoid agonist, WIN 55,212-2, in the orofacial and temporomandibular formalin tests.
Topics: Analgesics; Analgesics, Opioid; Anesthetics, Dissociative; Animals; Anti-Inflammatory Agents, Non-St | 2010 |
Inhibiting astrocytic activation: a novel analgesic mechanism of ketamine at the spinal level?
Topics: Analgesics; Anesthesia; Animals; Astrocytes; Disease Models, Animal; Drug Administration Routes; Gli | 2009 |
Propofol/alfentanil and propofol/ketamine procedural sedation in children with acute lymphoblastic leukaemia: safety, efficacy and their correlation with pain neuromediator expression.
Topics: Adolescent; Alfentanil; Anxiety; Child; Child, Preschool; Conscious Sedation; Cross-Over Studies; Dr | 2010 |
An observational study on the effect of S+-ketamine on chronic pain versus experimental acute pain in Complex Regional Pain Syndrome type 1 patients.
Topics: Acute Disease; Adult; Analgesics; Analysis of Variance; Chronic Disease; Dose-Response Relationship, | 2010 |
Ketamine and chronic pain--going the distance.
Topics: Anesthetics, Dissociative; Chronic Disease; Humans; Ketamine; Pain | 2009 |
Ketamine and midazolam in combination.
Topics: Adolescent; Adult; Aged; Analgesia, Patient-Controlled; Analgesics; Bandages; Burns; Drug Therapy, C | 2009 |
Can ketamine prescribed for pain cause damage to the urinary tract?
Topics: Adult; Aged; Analgesics; Fatal Outcome; Female; Humans; Ketamine; Male; Middle Aged; Pain; Palliativ | 2009 |
Preventing pain on injection of propofol: a comparison between peripheral ketamine pre-treatment and ketamine added to propofol.
Topics: Adult; Anesthetics, Intravenous; Female; Humans; Injections, Intravenous; Ketamine; Male; Middle Age | 2009 |
Opioid switching and burst ketamine to improve the opioid response in patients with movement-related pain due to bone metastases.
Topics: Analgesics, Opioid; Anesthetics, Dissociative; Bone Neoplasms; Humans; Ketamine; Male; Middle Aged; | 2009 |
Ketamine mouthwash for mucositis pain.
Topics: Analgesics; Humans; Ketamine; Medical Audit; Mouthwashes; Mucositis; Pain; Retrospective Studies | 2009 |
S(+)-ketamine effect on experimental pain and cardiac output: a population pharmacokinetic-pharmacodynamic modeling study in healthy volunteers.
Topics: Adolescent; Adult; Algorithms; Anesthetics, Dissociative; Cardiac Output; Dose-Response Relationship | 2009 |
[Sedation using ketamine for pain procedures in Pediatric Oncology.].
Topics: Child; Drug Therapy, Combination; Humans; Hypnotics and Sedatives; Ketamine; Midazolam; Pain | 2009 |
Mechanisms and treatment of neuropathic pain.
Topics: Afferent Pathways; Analgesics; Antidepressive Agents; Antidepressive Agents, Tricyclic; Clinical Tri | 2009 |
Use of low-dose ketamine infusion for pediatric patients with sickle cell disease-related pain: a case series.
Topics: Adolescent; Analgesics; Anemia, Sickle Cell; Child; Dose-Response Relationship, Drug; Female; Humans | 2010 |
Use of low-dose ketamine infusion for pediatric patients with sickle cell disease-related pain: a case series.
Topics: Adolescent; Analgesics; Anemia, Sickle Cell; Child; Dose-Response Relationship, Drug; Female; Humans | 2010 |
Use of low-dose ketamine infusion for pediatric patients with sickle cell disease-related pain: a case series.
Topics: Adolescent; Analgesics; Anemia, Sickle Cell; Child; Dose-Response Relationship, Drug; Female; Humans | 2010 |
Use of low-dose ketamine infusion for pediatric patients with sickle cell disease-related pain: a case series.
Topics: Adolescent; Analgesics; Anemia, Sickle Cell; Child; Dose-Response Relationship, Drug; Female; Humans | 2010 |
Total procedural requirements as indication for emergency department sedation.
Topics: Analgesics; Anesthetics, Dissociative; Conscious Sedation; Emergency Service, Hospital; Female; Huma | 2010 |
Human experimental pain models 3: heat/capsaicin sensitization and intradermal capsaicin models.
Topics: Alfentanil; Analgesics, Opioid; Capsaicin; Hot Temperature; Humans; Hyperalgesia; Injections, Intrad | 2010 |
Upper gastrointestinal problems in inhalational ketamine abusers.
Topics: Administration, Inhalation; Adult; Analgesics; China; Cohort Studies; Female; Gastritis; Humans; Inc | 2010 |
Management of cancer pain: ESMO Clinical Practice Guidelines.
Topics: Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; D | 2010 |
Ketamine for managing perioperative pain in opioid-dependent patients with chronic pain: a unique indication?
Topics: Chronic Disease; Disease Management; Humans; Ketamine; Opioid-Related Disorders; Pain; Pain, Postope | 2010 |
Taming the ketamine tiger. 1965.
Topics: Analgesics; Animals; Behavior, Addictive; Hallucinogens; History, 20th Century; Humans; Ketamine; Pa | 2010 |
The addition of ketamine to a morphine nurse- or patient-controlled analgesia infusion (PCA/NCA) increases analgesic efficacy in children with mucositis pain.
Topics: Adolescent; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, Dissociative; Child; Chi | 2010 |
Low-dose ketamine for analgesia in the ED: a retrospective case series.
Topics: Adult; Analgesia; Analgesics; Emergency Service, Hospital; Emergency Treatment; Female; Health Care | 2010 |
Low-dose ketamine for analgesia in the ED: a retrospective case series.
Topics: Adult; Analgesia; Analgesics; Emergency Service, Hospital; Emergency Treatment; Female; Health Care | 2010 |
Low-dose ketamine for analgesia in the ED: a retrospective case series.
Topics: Adult; Analgesia; Analgesics; Emergency Service, Hospital; Emergency Treatment; Female; Health Care | 2010 |
Low-dose ketamine for analgesia in the ED: a retrospective case series.
Topics: Adult; Analgesia; Analgesics; Emergency Service, Hospital; Emergency Treatment; Female; Health Care | 2010 |
Low-dose ketamine for analgesia in the ED: a retrospective case series.
Topics: Adult; Analgesia; Analgesics; Emergency Service, Hospital; Emergency Treatment; Female; Health Care | 2010 |
Low-dose ketamine for analgesia in the ED: a retrospective case series.
Topics: Adult; Analgesia; Analgesics; Emergency Service, Hospital; Emergency Treatment; Female; Health Care | 2010 |
Low-dose ketamine for analgesia in the ED: a retrospective case series.
Topics: Adult; Analgesia; Analgesics; Emergency Service, Hospital; Emergency Treatment; Female; Health Care | 2010 |
Low-dose ketamine for analgesia in the ED: a retrospective case series.
Topics: Adult; Analgesia; Analgesics; Emergency Service, Hospital; Emergency Treatment; Female; Health Care | 2010 |
Low-dose ketamine for analgesia in the ED: a retrospective case series.
Topics: Adult; Analgesia; Analgesics; Emergency Service, Hospital; Emergency Treatment; Female; Health Care | 2010 |
Low-dose ketamine for analgesia in the ED: a retrospective case series.
Topics: Adult; Analgesia; Analgesics; Emergency Service, Hospital; Emergency Treatment; Female; Health Care | 2010 |
Low-dose ketamine for analgesia in the ED: a retrospective case series.
Topics: Adult; Analgesia; Analgesics; Emergency Service, Hospital; Emergency Treatment; Female; Health Care | 2010 |
Low-dose ketamine for analgesia in the ED: a retrospective case series.
Topics: Adult; Analgesia; Analgesics; Emergency Service, Hospital; Emergency Treatment; Female; Health Care | 2010 |
Low-dose ketamine for analgesia in the ED: a retrospective case series.
Topics: Adult; Analgesia; Analgesics; Emergency Service, Hospital; Emergency Treatment; Female; Health Care | 2010 |
Low-dose ketamine for analgesia in the ED: a retrospective case series.
Topics: Adult; Analgesia; Analgesics; Emergency Service, Hospital; Emergency Treatment; Female; Health Care | 2010 |
Low-dose ketamine for analgesia in the ED: a retrospective case series.
Topics: Adult; Analgesia; Analgesics; Emergency Service, Hospital; Emergency Treatment; Female; Health Care | 2010 |
Low-dose ketamine for analgesia in the ED: a retrospective case series.
Topics: Adult; Analgesia; Analgesics; Emergency Service, Hospital; Emergency Treatment; Female; Health Care | 2010 |
Achieving prehospital analgesia.
Topics: Accidents, Traffic; Adult; Analgesics; Emergency Medical Services; Femoral Fractures; Humans; Ketami | 2012 |
Morphine exposure in early life increases nociceptive behavior in a rat formalin tonic pain model in adult life.
Topics: Age Factors; Analgesics, Opioid; Analysis of Variance; Anesthetics, Dissociative; Animals; Animals, | 2011 |
Effect of sub-anesthetic xylazine and ketamine ('ketamine stun') administered to calves immediately prior to castration.
Topics: Anesthesia, Intravenous; Anesthetics, Dissociative; Animals; Cattle; Dose-Response Relationship, Dru | 2010 |
Low-dose ketamine for analgesia in the ED: a retrospective case series.
Topics: Analgesics; Emergency Service, Hospital; Humans; Ketamine; Pain; Retrospective Studies | 2011 |
Pain management in 100 episodes of severe mucositis in children.
Topics: Adolescent; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, Dissociative; Child; Dru | 2011 |
Exploring the pharmacokinetics of oral ketamine in children undergoing burns procedures.
Topics: Administration, Oral; Anesthetics, Dissociative; Biological Availability; Biotransformation; Burns; | 2011 |
[Effect of intrathecal ketamine injection on protein kinase C expression in the spinal dorsal horn of rats with formalin-induced pain].
Topics: Animals; Formaldehyde; Injections, Spinal; Ketamine; Male; Pain; Pain Measurement; Posterior Horn Ce | 2011 |
Combining ketamine and virtual reality pain control during severe burn wound care: one military and one civilian patient.
Topics: Adult; Analgesia; Analgesics; Burns; Computer Simulation; Debridement; Humans; Ketamine; Male; Milit | 2011 |
The effect of target-controlled infusion of low-dose ketamine on heat pain and temporal summation threshold.
Topics: Adult; Anesthetics, Dissociative; Electric Stimulation; Female; Hot Temperature; Humans; Infusion Pu | 2011 |
Nonselective and NR2B-selective N-methyl-D-aspartic acid receptor antagonists produce antinociception and long-term relief of allodynia in acute and neuropathic pain.
Topics: Acute Disease; Analgesics; Animals; Chronic Disease; Cold Temperature; Data Interpretation, Statisti | 2011 |
Successful reversal of hyperalgesia/myoclonus complex with low-dose ketamine infusion.
Topics: Analgesics, Opioid; Humans; Hydromorphone; Hyperalgesia; Infusions, Intravenous; Ketamine; Male; Mid | 2012 |
Ketamine activates the L-arginine/Nitric oxide/cyclic guanosine monophosphate pathway to induce peripheral antinociception in rats.
Topics: Analgesia; Anesthetics, Dissociative; Animals; Arginine; Cyclic AMP; Dinoprostone; Drug Synergism; E | 2011 |
Ketamine infusion for sickle cell crisis pain in an adult.
Topics: Adult; Analgesics; Anemia, Sickle Cell; Humans; Ketamine; Male; Pain; Pain Measurement; Treatment Ou | 2011 |
[Cystitis and ketamine associated bladder dysfunction].
Topics: Adolescent; Adult; Cross-Sectional Studies; Cystitis; Dose-Response Relationship, Drug; Excitatory A | 2012 |
Arresting the development of morphine tolerance and dependence.
Topics: Analgesics; Animals; Drug Tolerance; Humans; Ketamine; Morphine Dependence; Naltrexone; Narcotic Ant | 2011 |
Synthesis and study the analgesic effects of new analogues of ketamine on female wistar rats.
Topics: Analgesics; Animals; Female; Formaldehyde; Ketamine; Molecular Structure; Pain; Rats; Rats, Wistar | 2012 |
Epidural ketamine in the dromedary camel.
Topics: Analgesics; Anesthesia, Epidural; Animals; Dose-Response Relationship, Drug; Ketamine; Male; Pain | 2012 |
Mood and pain responses to repeat dose intramuscular ketamine in a depressed patient with advanced cancer.
Topics: Adult; Anesthetics, Dissociative; Depressive Disorder, Major; Disease Progression; Dysthymic Disorde | 2012 |
[Low dose ketamine for pediatric procedure-related pain].
Topics: Analgesics; Child; Humans; Ketamine; Pain; Pain Management; Pediatrics; Practice Guidelines as Topic | 2012 |
Noxious stimulation attenuates ketamine-induced neuroapoptosis in the developing rat brain.
Topics: Animals; Apoptosis; Brain; Caspase 3; Cyclin D1; Freund's Adjuvant; Glycogen Synthase Kinase 3; Glyc | 2012 |
Impact of general injection anaesthesia and analgesia on post-castration behaviour and teat order of piglets.
Topics: Anesthetics, General; Animal Welfare; Animals; Animals, Newborn; Animals, Suckling; Anti-Inflammator | 2012 |
Low-dose ketamine analgesia: patient and physician experience in the ED.
Topics: Adult; Analgesics; Attitude of Health Personnel; Conscious Sedation; Emergency Service, Hospital; Fe | 2013 |
Low-dose ketamine analgesia: patient and physician experience in the ED.
Topics: Adult; Analgesics; Attitude of Health Personnel; Conscious Sedation; Emergency Service, Hospital; Fe | 2013 |
Low-dose ketamine analgesia: patient and physician experience in the ED.
Topics: Adult; Analgesics; Attitude of Health Personnel; Conscious Sedation; Emergency Service, Hospital; Fe | 2013 |
Low-dose ketamine analgesia: patient and physician experience in the ED.
Topics: Adult; Analgesics; Attitude of Health Personnel; Conscious Sedation; Emergency Service, Hospital; Fe | 2013 |
Emerging applications of low-dose ketamine for pain management in the ED.
Topics: Adult; Analgesics; Emergency Service, Hospital; Female; Humans; Ketamine; Male; Middle Aged; Pain | 2013 |
Effects of propofol, sevoflurane, remifentanil, and (S)-ketamine in subanesthetic concentrations on visceral and somatosensory pain-evoked potentials.
Topics: Adult; Analgesics, Opioid; Anesthetics, Dissociative; Anesthetics, Inhalation; Anesthetics, Intraven | 2013 |
Involvement of N-methyl-D-aspartate receptors in nociception in the cyclophosphamide-induced vesical pain model in the conscious rat.
Topics: Acrolein; Animals; Antineoplastic Agents, Alkylating; Behavior, Animal; Cyclophosphamide; Cystitis; | 2002 |
Successful use of oral methadone after failure of intravenous morphine and ketamine.
Topics: Acute Disease; Administration, Oral; Adult; Analgesia, Patient-Controlled; Analgesics; Analgesics, O | 2002 |
Analgesia with ketamine in a patient with perioperative opioid tolerance.
Topics: Analgesics; Analgesics, Opioid; Drug Tolerance; Humans; Ketamine; Laparotomy; Pain | 2002 |
Modulation of formalin-induced behaviors and edema by local and systemic administration of dextromethorphan, memantine and ketamine.
Topics: Animals; Behavior, Animal; Dextromethorphan; Dose-Response Relationship, Drug; Edema; Excitatory Ami | 2002 |
Dextromethorphan and ketamine potentiate the antinociceptive effects of mu- but not delta- or kappa-opioid agonists in a mouse model of acute pain.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics | 2002 |
Venous malformations associated with central pain: report of a case.
Topics: Analgesics, Opioid; Dextromethorphan; Excitatory Amino Acid Antagonists; Female; Humans; Intracrania | 2002 |
Large-amplitude 5-HT1A receptor activation: a new mechanism of profound, central analgesia.
Topics: Acetates; Adrenergic Uptake Inhibitors; Amines; Aminopyridines; Analgesia; Analgesics; Animals; Cell | 2002 |
Interactions of NMDA antagonists and an alpha 2 agonist with mu, delta and kappa opioids in an acute nociception assay.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenergic | 2002 |
Antinociceptive effect in mice of intraperitoneal N-methyl-D-aspartate receptor antagonists in the formalin test.
Topics: Animals; Behavior, Animal; Dextromethorphan; Dizocilpine Maleate; Dose-Response Relationship, Drug; | 2003 |
Peripheral interactions between dextromethorphan, ketamine and amitriptyline on formalin-evoked behaviors and paw edema in rats.
Topics: Amitriptyline; Analgesics, Non-Narcotic; Animals; Behavior, Animal; Dextromethorphan; Dose-Response | 2003 |
Reticular thalamic responses to nociceptive inputs in anesthetized rats.
Topics: Action Potentials; Afferent Pathways; Anesthesia; Anesthetics, Dissociative; Anesthetics, Inhalation | 2003 |
Burst ketamine to reverse opioid tolerance in cancer pain.
Topics: Aged; Analgesics, Opioid; Drug Tolerance; Excitatory Amino Acid Antagonists; Female; Humans; Ketamin | 2003 |
A retrospective comparison of the dose ratio between subcutaneous and oral ketamine.
Topics: Administration, Oral; Adult; Analgesics; Dose-Response Relationship, Drug; Humans; Infusions, Intrav | 2003 |
Topical capsaicin-induced allodynia in unanesthetized primates: pharmacological modulation.
Topics: Aminobutyrates; Analgesics; Animals; Benzeneacetamides; Capsaicin; Disease Models, Animal; Dizocilpi | 2003 |
Pharmacological modulation of experimental phasic and tonic muscle pain by morphine, alfentanil and ketamine in healthy volunteers.
Topics: Adult; Alfentanil; Electric Stimulation; Female; Humans; Ketamine; Male; Morphine; Muscle, Skeletal; | 2003 |
Effect of long-term ketamine administration on vocalization to paw pressure and on spinal wind-up activity in monoarthritic rats.
Topics: Analgesics; Analysis of Variance; Animals; Arthritis, Experimental; Arthritis, Infectious; Chronic D | 2003 |
Ketamine to control pain.
Topics: Adult; Analgesics; Fatal Outcome; Female; Humans; Infusions, Intravenous; Ketamine; Neoplasms; Pain | 2003 |
Ketamine in the management of chronic pancreatic pain.
Topics: Aged; Analgesics; Chronic Disease; Humans; Ketamine; Male; Pain; Pancreatitis | 2003 |
C-fos expression in rat brain nuclei following incisor tooth movement.
Topics: Analgesics; Animals; Brain; Genes, fos; Incisor; Ketamine; Locus Coeruleus; Male; Models, Animal; Ne | 2004 |
Evaluation of the use of anesthesia and analgesia in reptiles.
Topics: Analgesia; Analgesics; Anesthesia; Anesthetics, Inhalation; Animals; Butorphanol; Humans; Hypothermi | 2004 |
Effects of anesthesia and nociceptive stimulation in an experimental model of brachial plexus avulsion.
Topics: Anesthesia; Animals; Brachial Plexus; Ketamine; Male; Models, Animal; Nociceptors; Pain; Pentobarbit | 2004 |
Effects of ketamine anesthesia on central nociceptive processing in the rat: a 2-deoxyglucose study.
Topics: Analysis of Variance; Anesthesia; Anesthetics, Dissociative; Animals; Behavior, Animal; Blood Glucos | 2004 |
Ketamine to reduce propofol injection pain.
Topics: Anesthetics, Intravenous; Anesthetics, Local; Child; Clinical Trials as Topic; Drug Combinations; Dr | 2004 |
Subanesthetic ketamine: an essential adjuvant for intractable cancer pain.
Topics: Adult; Analgesics; Anesthetics, Dissociative; Chemotherapy, Adjuvant; Female; Femoral Neoplasms; Hum | 2004 |
Intraarticular pretreatment with ketamine and memantine could prevent arthritic pain: relevance to the decrease of spinal c-fos expression in rats.
Topics: Animals; Arthritis, Experimental; Behavior, Animal; Body Weight; Carrageenan; Excitatory Amino Acid | 2004 |
Safety and efficacy of intranasal ketamine in a mixed population with chronic pain.
Topics: Administration, Intranasal; Chronic Disease; Clinical Trials as Topic; Humans; Ketamine; Pain | 2004 |
Comment on: Bell RF, Kalso K. Is intranasal ketamine an appropriate treatment for chronic non-cancer breakthrough pain? Pain 2004;108:1-2.
Topics: Administration, Intranasal; Chronic Disease; Humans; Ketamine; Pain | 2004 |
Ketamine potentiates the effect of electroacupuncture on mechanical allodynia in a rat model of neuropathic pain.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Electroacupuncture; Female; Ketam | 2004 |
[Case of radial nerve injury induced by withdrawing a catheter from the cephalic vein].
Topics: Adult; Arm; Brachiocephalic Veins; Catheterization, Peripheral; Catheters, Indwelling; Education, Me | 2004 |
Differences between primary somatosensory cortex- and vertex-derived somatosensory-evoked potentials in the rat.
Topics: Anesthetics; Animals; Brain Mapping; Cerebral Cortex; Electric Stimulation; Evoked Potentials, Somat | 2004 |
Pain on injection of rocuronium: influence of ketamine pretreatment.
Topics: Androstanols; Anesthetics, Dissociative; Humans; Injections; Intraoperative Complications; Ketamine; | 2005 |
Pre-versus post-formalin effects of intrathecal ketamine on spinal Fos-like immunoreactivity in rats.
Topics: Analgesics; Animals; Formaldehyde; Injections, Spinal; Ketamine; Male; Neurons; Pain; Pain Measureme | 2004 |
Prospective audit of short-term concurrent ketamine, opioid and anti-inflammatory ('triple-agent') therapy for episodes of acute on chronic pain.
Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Analgesics; Analgesics, Opioid; Anti-Inflammatory Age | 2005 |
Ketamine enhances the efficacy to and delays the development of tolerance to electroacupuncture-induced antinociception in rats.
Topics: Adaptation, Physiological; Analgesics; Animals; Brain; Dose-Response Relationship, Drug; Electroacup | 2005 |
Preemptive effect of intravenous ketamine in the rat: concordance between pain behavior and spinal fos-like immunoreactivity.
Topics: Analgesics; Analysis of Variance; Animals; Behavior, Animal; Disease Models, Animal; Disinfectants; | 2005 |
Neuropathological findings after continuous intrathecal administration of S(+)-ketamine for the management of neuropathic cancer pain.
Topics: Analgesics; Female; Humans; Ketamine; Middle Aged; Neoplasms; Pain; Postmortem Changes; Spinal Cord | 2005 |
Combined therapy with clonidine and amantadine may act in two stages of glutamate-mediated neuropathic pain caused by a needle puncture in an upper extremity.
Topics: Adrenergic alpha-Agonists; Adult; Amantadine; Analgesics, Non-Narcotic; Calcium Channel Blockers; Ca | 2005 |
Alternative treatments of breakthrough pain in patients receiving spinal analgesics for cancer pain.
Topics: Administration, Sublingual; Adult; Aged; Analgesics; Anesthetics, Local; Bupivacaine; Female; Humans | 2005 |
Effects of ketamine on acute somatic nociception in wild-type and N-methyl-D-aspartate (NMDA) receptor epsilon1 subunit knockout mice.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Aci | 2006 |
Effects of initial pain treatment on sedation recovery time in pediatric emergency care.
Topics: Adolescent; Analgesics; Analgesics, Opioid; Anesthesia Recovery Period; Child; Child, Preschool; Con | 2006 |
The potential role of spinal ketamine in multi-component antinociception.
Topics: Analgesics; Animals; Drug Therapy, Combination; Injections, Spinal; Ketamine; Male; Pain; Pain Measu | 2006 |
[Postponed or canceled drug challenge tests and side effects of the test drug--a report of four cases].
Topics: Adult; Aged; Arthritis, Rheumatoid; Chronic Disease; Female; Fibromyalgia; Humans; Intervertebral Di | 2006 |
Spinal ventral root after-discharges as a pain index: involvement of NK-1 and NMDA receptors.
Topics: Action Potentials; Analysis of Variance; Animals; Benzylamines; Bridged Bicyclo Compounds, Heterocyc | 2006 |
The antiallodynic effect of NMDA antagonists in neuropathic pain outlasts the duration of the in vivo NMDA antagonism.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analgesics, Opioid; Animals; Cold Temperat | 2006 |
Safe and efficacious use of procedural sedation and analgesia by non-anesthesiologists in a pediatric hematology-oncology unit.
Topics: Adolescent; Analgesics; Child; Child, Preschool; Drug Therapy, Combination; Female; Follow-Up Studie | 2006 |
Enhancement of morphine antinociception with the peptide N-methyl-D-aspartate receptor antagonist [Ser1]-histogranin in the rat formalin test.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Behavior, Animal; Dose-Response Relationship, Dru | 2006 |
Depression of NMDA-receptor-mediated segmental transmission by ketamine and ketoprofen, but not L-NAME, on the in vitro neonatal rat spinal cord preparation.
Topics: Afferent Pathways; Animals; Animals, Newborn; Cyclooxygenase Inhibitors; Dose-Response Relationship, | 2006 |
Subanesthetic ketamine for cancer pain and scientific rigor in cancer pain trials. A reply to Jackson et al.
Topics: Analgesics; Clinical Trials as Topic; Humans; Ketamine; Neoplasms; Pain | 2006 |
Ketamine and HTLV-1 myelopathy: NMDA blockade and immunomodulation?
Topics: Excitatory Amino Acid Antagonists; HTLV-I Infections; Human T-lymphotropic virus 1; Humans; Immunolo | 2006 |
Procedural sedation and analgesia in children.
Topics: Analgesia; Analgesics; Child; Conscious Sedation; Drug Combinations; Humans; Hypnotics and Sedatives | 2006 |
Evidence-based pain management and palliative care in Issue One for 2006 of The Cochrane Library.
Topics: Analgesics; Analgesics, Opioid; Clinical Trials as Topic; Cryotherapy; Evidence-Based Medicine; Huma | 2006 |
Characterization of the antinociceptive and anti-inflammatory activities of riboflavin in different experimental models.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Body Temperature; Carrageenan; Dose | 2006 |
[Dextromethorphan enhances analgesic activity of propacetamol--experimental study].
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Behavior, Animal; Dextromethorphan; Dose-Response | 2005 |
Pain management in fulminating ulcerative colitis.
Topics: Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Child; Colitis, Ulcerative; Contraind | 2006 |
Consigning "brutacaine" to history: a survey of pharmacological techniques to facilitate painful procedures in children in emergency departments in the UK.
Topics: Administration, Intranasal; Administration, Topical; Analgesics; Anesthesia, Local; Child; Emergency | 2006 |
[Effect of intrathecal katemine on the expression of nNOS in spinal dorsal horn in rats with formalin pain].
Topics: Analgesics; Animals; Formaldehyde; Injections, Spinal; Ketamine; Male; Nitric Oxide Synthase Type I; | 2006 |
Deep sedation with intravenous infusion of combined propofol and ketamine during dressing changes and whirlpool bath in patients with severe epidermolysis bullosa.
Topics: Adolescent; Analgesics; Anesthetics, Intravenous; Anti-Bacterial Agents; Antibiotics, Antitubercular | 2007 |
[Italian guidelines and recommendations for prevention and treatment of pain in the newborn].
Topics: Adjuvants, Anesthesia; Analgesics; Analgesics, Opioid; Anesthetics, Local; Atropine; Drug Therapy, C | 2006 |
Ketamine reduces the cell death following inflammatory pain in newborn rat brain.
Topics: Analgesics; Animals; Animals, Newborn; Behavior, Animal; Brain; Cell Death; Female; Humans; Infant, | 2007 |
Why not ketamine?
Topics: Excitatory Amino Acid Antagonists; Humans; Ketamine; Pain | 2007 |
Ketamine: it is not just for kids anymore.
Topics: Analgesics; Analgesics, Opioid; Anesthetics, Dissociative; Animals; Conscious Sedation; Drug Therapy | 2007 |
Ketamine versus lidocaine for the pain of propofol injection.
Topics: Humans; Injections, Intravenous; Ketamine; Lidocaine; Pain; Propofol | 2007 |
Ketamine for reducing propofol-induced pain.
Topics: Humans; Ketamine; Pain; Propofol | 2007 |
Long-term use of an intravenous ketamine infusion in a child with significant burns.
Topics: Analgesia; Analgesics; Burns; Child; Humans; Infusions, Intravenous; Ketamine; Male; Pain; Time Fact | 2007 |
Acupuncture, ketamine and piriformis syndrome--a case report from palliative care.
Topics: Acupuncture Therapy; Amines; Analgesics; Combined Modality Therapy; Cyclohexanecarboxylic Acids; Gab | 2007 |
Ketamine for prehospital use: new look at an old drug.
Topics: Adolescent; Adult; Aged; Air Ambulances; Analgesics; Anesthetics, Dissociative; Child; Child, Presch | 2007 |
Anaesthesia in retinopathy of prematurity treatment.
Topics: Analgesics; Anesthesia; Humans; Infant, Newborn; Ketamine; Laser Therapy; Pain; Retinopathy of Prema | 2008 |
World Institute of Pain (WIP)--Fourth World Congress.
Topics: Animals; Back Pain; Clinical Trials as Topic; Humans; Ketamine; Neoplasms; Pain; Pain Management; Ra | 2007 |
Use of ketamine for ischemic pain in end-stage renal failure.
Topics: Adult; Analgesics; Humans; Ischemia; Ketamine; Kidney Failure, Chronic; Male; Pain | 2008 |
Oral ketamine for pain relief in a child with abdominal malignancy.
Topics: Abdominal Neoplasms; Administration, Oral; Analgesics; Child, Preschool; Fatal Outcome; Humans; Keta | 2009 |
Discrimination of electric shock: effects of some opioid and nonopioid drugs.
Topics: Analgesics, Opioid; Animals; Drug Interactions; Electroshock; Haplorhini; Ketamine; Male; Narcotic A | 1980 |
[Treatment of pain and anesthesia in emergency and catastrophe medicine (author's transl)].
Topics: Analgesics, Opioid; Anesthesia, General; Disasters; Emergencies; Humans; Ketamine; Pain; Wounds and | 1981 |
[Principles of preclinical pain treatment of emergency patients].
Topics: Analgesics; Anesthesia, Inhalation; Anesthesia, Local; Emergencies; First Aid; Humans; Ketamine; Mep | 1984 |
[Analgesia and anesthesia with ketamine at the emergency site and in transport].
Topics: Anesthesia, Intravenous; Dose-Response Relationship, Drug; Emergencies; First Aid; Humans; Ketamine; | 1984 |
Infusion analgesia for acute war injuries. A comparison of pentazocine and ketamine.
Topics: Adult; Analgesia; Blood Pressure; Cambodia; Female; Humans; Infusions, Parenteral; Ketamine; Male; M | 1984 |
Bioavailability, pharmacokinetics, and analgesic activity of ketamine in humans.
Topics: Administration, Oral; Adult; Analgesics; Biological Availability; Humans; Injections, Intramuscular; | 1982 |
Bioavailability, pharmacokinetics, and analgesic activity of ketamine in humans.
Topics: Administration, Oral; Adult; Analgesics; Biological Availability; Humans; Injections, Intramuscular; | 1982 |
Bioavailability, pharmacokinetics, and analgesic activity of ketamine in humans.
Topics: Administration, Oral; Adult; Analgesics; Biological Availability; Humans; Injections, Intramuscular; | 1982 |
Bioavailability, pharmacokinetics, and analgesic activity of ketamine in humans.
Topics: Administration, Oral; Adult; Analgesics; Biological Availability; Humans; Injections, Intramuscular; | 1982 |
Activation of the supraspinal pain inhibition system by ketamine hydrochloride.
Topics: Animals; Bradykinin; Cats; Decerebrate State; Female; Ketamine; Male; Pain; Pentobarbital; Spinal Co | 1981 |
Effective treatment of severe cancer pain of the head using low-dose ketamine in an opioid-tolerant patient.
Topics: Adult; Carcinoma, Squamous Cell; Dose-Response Relationship, Drug; Drug Tolerance; Humans; Ketamine; | 1995 |
Effective treatment of severe cancer pain of the head using low-dose ketamine in an opioid-tolerant patient.
Topics: Adult; Carcinoma, Squamous Cell; Dose-Response Relationship, Drug; Drug Tolerance; Humans; Ketamine; | 1995 |
Effective treatment of severe cancer pain of the head using low-dose ketamine in an opioid-tolerant patient.
Topics: Adult; Carcinoma, Squamous Cell; Dose-Response Relationship, Drug; Drug Tolerance; Humans; Ketamine; | 1995 |
Effective treatment of severe cancer pain of the head using low-dose ketamine in an opioid-tolerant patient.
Topics: Adult; Carcinoma, Squamous Cell; Dose-Response Relationship, Drug; Drug Tolerance; Humans; Ketamine; | 1995 |
Differential effects of N-methyl-D-aspartate (NMDA) and non-NMDA receptor antagonists on the responses of rat spinal neurons with joint input.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4- | 1993 |
Response of chronic neuropathic pain syndromes to ketamine: a role for norketamine?
Topics: Humans; Ketamine; Pain; Pain, Intractable | 1995 |
The involvement of N-methyl-D-aspartate (NMDA) and non-NMDA receptors in the responsiveness of rat spinal neurons with input from the chronically inflamed ankle.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Afferent Pathways; Animals; Ankle | 1994 |
[Analgetic ketamine feasible in ambulance emergency care].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Akathisia, Drug-Induced; Child; Cognition Disorders; Eme | 1994 |
Paradoxical pain.
Topics: Adenocarcinoma; Breast Neoplasms; Female; Humans; Ketamine; Middle Aged; Morphine; Pain | 1993 |
Intrathecal treatment with dextrorphan or ketamine potently reduces pain-related behaviors in a rat model of peripheral mononeuropathy.
Topics: Animals; Behavior, Animal; Dextrorphan; Injections, Spinal; Ketamine; Male; Pain; Pain Measurement; | 1993 |
Stewart smiled.
Topics: Child; Conscious Sedation; Humans; Ketamine; Pain | 1993 |
Effect of propofol on spinal dorsal horn neurons. Comparison with lack of ketamine effects.
Topics: Action Potentials; Anesthetics, Intravenous; Animals; Blood Pressure; Cats; Ketamine; Neurons; Pain; | 1995 |
[Ketamine and phantom pain].
Topics: Anesthetics, Dissociative; Humans; Ketamine; Nociceptors; Pain; Phantom Limb | 1995 |
A correlogram analysis of the activity in the rostral ventromedial medulla of awake rats and in rats anesthetized with ketamine or pentobarbital following the administration of morphine.
Topics: Action Potentials; Analgesics, Opioid; Animals; Data Interpretation, Statistical; Drug Combinations; | 1995 |
Systemic ketamine attenuates nociceptive behaviors in a rat model of peripheral neuropathy.
Topics: Animals; Behavior, Animal; Cold Temperature; Dose-Response Relationship, Drug; Excitatory Amino Acid | 1996 |
[Conduction anesthesia and analgesia in emergency cases. From pain to its treatment].
Topics: Analgesia; Analgesics, Opioid; Anesthesia, Conduction; Anti-Inflammatory Agents, Non-Steroidal; Emer | 1995 |
[Cancer pain: beneficial effect of ketamine addition to spinal administration of morphine-clonidine-lidocaine mixture].
Topics: Aged; Analgesics; Catheters, Indwelling; Clonidine; Drug Combinations; Drug Synergism; Female; Human | 1996 |
Acute phantom limb pain controlled by ketamine.
Topics: Acute Disease; Adolescent; Anesthetics, Dissociative; Humans; Infusions, Intravenous; Ketamine; Male | 1995 |
Ketamine injection used orally.
Topics: Administration, Oral; Adult; Drug Resistance; Excitatory Amino Acid Antagonists; Hospice Care; Human | 1996 |
[Analgesic effect of ketamine in a patient with neuropathic pain].
Topics: Administration, Oral; Anesthetics, Dissociative; Female; Fibromyalgia; Humans; Ketamine; Middle Aged | 1996 |
Efficacy of spinal NMDA receptor antagonism in formalin hyperalgesia and nerve injury evoked allodynia in the rat.
Topics: 2-Amino-5-phosphonovalerate; Analgesics; Animals; Dextromethorphan; Dextrorphan; Dizocilpine Maleate | 1997 |
Successful use of ketamine for central pain.
Topics: Adult; Humans; Ketamine; Male; Pain | 1997 |
Long-term treatment of chronic neuropathic pain with the NMDA (N-methyl-D-aspartate) receptor antagonist ketamine.
Topics: Central Nervous System; Chronic Disease; Excitatory Amino Acid Antagonists; Humans; Ketamine; Pain | 1997 |
Ketamine: relief from chronic pain through actions at the NMDA receptor?
Topics: Anesthetics, Dissociative; Chronic Disease; Excitatory Amino Acid Antagonists; Humans; Ketamine; Pai | 1996 |
Phantom limb pain.
Topics: Adolescent; Analgesics; Anesthetics, Dissociative; Humans; Ketamine; Nociceptors; Pain; Phantom Limb | 1996 |
Reply to S.T. Meller: Ketamine: relief from chronic pain through actions at the NMDA receptor.
Topics: Chronic Disease; Excitatory Amino Acid Antagonists; Humans; Ketamine; Pain; Receptors, N-Methyl-D-As | 1997 |
Subpial vacuolar myelopathy after intrathecal ketamine: report of a case.
Topics: Anesthetics, Intravenous; Carcinoid Tumor; Chronic Disease; Fatal Outcome; Humans; Injections, Spina | 1997 |
Preemptive intrathecal ketamine delays mechanical hyperalgesia in the neuropathic rat.
Topics: Anesthetics, Dissociative; Animals; Female; Hyperalgesia; Injections, Spinal; Ketamine; Nerve Compre | 1998 |
Intraplantar injection of dextrorphan, ketamine or memantine attenuates formalin-induced behaviors.
Topics: Animals; Dextrorphan; Foot; Formaldehyde; Injections, Intradermal; Ketamine; Male; Memantine; Motor | 1998 |
The NMDA-receptor antagonist ketamine abolishes neuropathic pain after epidural administration in a clinical case.
Topics: Adolescent; Causalgia; Humans; Injections, Epidural; Ketamine; Leg; Male; Pain; Receptors, N-Methyl- | 1998 |
Substitution of another opioid for morphine. Opioid toxicity should be managed initially by decreasing the opioid dose.
Topics: Analgesics, Opioid; Anesthetics, Dissociative; Humans; Ketamine; Morphine; N-Methylaspartate; Pain; | 1998 |
Ketamine analgesia in vasculitic pain.
Topics: Aged; Aged, 80 and over; Analgesia; Anesthetics, Dissociative; Drug Therapy, Combination; Fatal Outc | 1998 |
Ketamine analgesia, NMDA receptors and the gates of perception.
Topics: Analgesics; Arteriosclerosis; Chronic Disease; Excitatory Amino Acid Antagonists; Humans; Ion Channe | 1998 |
Substitution of another opioid for morphine. Methadone can be used to manage neuropathic pain related to cancer.
Topics: Analgesics, Opioid; Anesthetics, Dissociative; Humans; Ketamine; Methadone; N-Methylaspartate; Neopl | 1998 |
Use of ketamine in a pain management protocol for repetitive procedures.
Topics: Anesthetics, Dissociative; Bandages; Child; Conscious Sedation; Debridement; Drug Therapy, Combinati | 1998 |
Sedation for pediatric procedures, using ketamine and midazolam, in a primarily adult intensive care unit: a retrospective evaluation.
Topics: Adolescent; Adult; Anesthetics, Combined; Anesthetics, Dissociative; Anesthetics, Intravenous; Child | 1998 |
Ketamine hydrochloride--an adjunct for analgesia in dogs with burn wounds.
Topics: Analgesics; Animals; Anti-Bacterial Agents; Burns; Dogs; Drug Therapy, Combination; Female; Ketamine | 1998 |
Oral ketamine is antinociceptive in the rat formalin test: role of the metabolite, norketamine.
Topics: Administration, Oral; Animals; Behavior, Animal; Binding, Competitive; Central Nervous System; Forma | 1999 |
Pre- versus postformalin effects of ketamine or large-dose alfentanil in the rat: discordance between pain behavior and spinal Fos-like immunoreactivity.
Topics: Alfentanil; Analgesics, Opioid; Animals; Formaldehyde; Ketamine; Male; Naloxone; Pain; Proto-Oncogen | 1999 |
Accident and emergency department led implementation of ketamine sedation in paediatric practice and parental response.
Topics: Anesthetics, Dissociative; Attitude to Health; Child; Child, Preschool; Conscious Sedation; Emergenc | 2000 |
Generalized hyperalgesia and allodynia following abrupt cessation of subcutaneous ketamine infusion.
Topics: Aged; Analgesics; Breast Neoplasms; Female; Humans; Hyperalgesia; Infusions, Intravenous; Injections | 1999 |
Use of intravenous ketamine-midazolam association for pain procedures in children with cancer. A prospective study.
Topics: Adolescent; Analgesics; Biopsy; Biopsy, Needle; Blood Pressure; Catheterization, Central Venous; Chi | 1999 |
Formalin-induced central sensitization in the rat: somatosensory evoked potential data.
Topics: Animals; Cerebral Cortex; Electric Stimulation; Evoked Potentials, Somatosensory; Formaldehyde; Hype | 2000 |
Comments on 'Ketamine hydrochloride--an adjunct for analgesia in dogs with burn wounds'.
Topics: Analgesia; Analgesics; Animals; Burns; Dogs; Ketamine; Pain | 1999 |
Repeated administration of low dose ketamine for the treatment of monoarthritic pain in the rat.
Topics: Analgesics; Animals; Ankle Joint; Arthritis, Experimental; Body Weight; Disease Models, Animal; Dose | 2000 |
NMDA receptor blockade: from the laboratory to clinical application.
Topics: Adjuvants, Anesthesia; Analgesics; Anesthesia, Epidural; Anesthetics, Dissociative; Evoked Potential | 2000 |
Comparison of the effects of MK-801, ketamine and memantine on responses of spinal dorsal horn neurones in a rat model of mononeuropathy.
Topics: Animals; Dizocilpine Maleate; Electric Stimulation; Electrophysiology; Excitatory Amino Acid Antagon | 2001 |
An unusual case of chronic neuropathic pain responds to an optimum frequency of intravenous ketamine infusions.
Topics: Adult; Chronic Disease; Excitatory Amino Acid Antagonists; Female; Humans; Ketamine; Pain; Phantom L | 2001 |
The reversal of fentanyl-induced tolerance by administration of "small-dose" ketamine.
Topics: Adult; Analgesics, Opioid; Anesthetics, Dissociative; Drug Therapy, Combination; Drug Tolerance; Fem | 2001 |
[Usefulness of epidural infusion of ketamine for relief of localized superficial pain].
Topics: Analgesia, Epidural; Analgesics; Female; Humans; Ketamine; Male; Middle Aged; Pain | 2001 |
The long-term antinociceptive effect of intrathecal S(+)-ketamine in a patient with established morphine tolerance.
Topics: Analgesics; Analgesics, Opioid; Anesthetics, Dissociative; Back Pain; Drug Tolerance; Female; Humans | 2001 |
In response to treatment of central post-stroke pain with oral ketamine by Pamela G. Vick and Tim J. Lamer.
Topics: Administration, Oral; Analgesics; Humans; Ketamine; Pain; Stroke | 2002 |
Low dose ketamine as an analgesic adjuvant in difficult pain syndromes: a strategy for conversion from parenteral to oral ketamine.
Topics: Administration, Oral; Adult; Aged; Chemotherapy, Adjuvant; Humans; Infusions, Parenteral; Ketamine; | 2002 |
Subcutaneous formalin and intraplantar carrageenan increase nitric oxide release as measured by in vivo voltammetry in the spinal cord.
Topics: Animals; Carrageenan; Excitatory Amino Acid Antagonists; Formaldehyde; Inflammation; Inflammation Me | 2002 |
Isobolographic analysis of the analgesic interactions between ketamine and tramadol.
Topics: Analgesics; Animals; Behavior, Animal; Central Nervous System; Dose-Response Relationship, Drug; Dru | 2002 |
Experimental conditions for the continuous subcutaneous infusion of four central analgesics in rats.
Topics: Acetates; Amines; Analgesics; Anesthetics, Dissociative; Animals; Anticonvulsants; Antidepressive Ag | 2002 |
Potentiation by ketamine of fentanyl antinociception. I. An experimental study in rats showing that ketamine administered by non-spinal routes targets spinal cord antinociceptive systems.
Topics: Analgesics; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Synergism; Electric | 2002 |
[Preliminary clinical observations on the use of the narcotic, Etomidate, in anesthesiology. Evaluation of the MPC dose and equivalent dose].
Topics: Adolescent; Adult; Anesthesia; Diazepam; Dose-Response Relationship, Drug; Etomidate; Humans; Imidaz | 1979 |
Hypno-analgesia and acupuncture analgesia: a neurophysiological reality?
Topics: Acupuncture Therapy; Adult; Analgesia; Analgesics; Blood Pressure; Brain; Computers; Electric Stimul | 1975 |
Effects of ketamine on sensory perception: evidence for a role of N-methyl-D-aspartate receptors.
Topics: Adult; Dizocilpine Maleate; Hearing; Humans; Ketamine; Male; Memory; Pain; Perception; Receptors, N- | 1992 |
Ketamine. A solution to procedural pain in burned children.
Topics: Burn Units; Burns; Child; Humans; Ketamine; Pain; Pediatric Nursing | 1992 |
[Effects of ketamine on behavioral responses to somatic and visceral stimuli in rats].
Topics: Animals; Injections, Intraperitoneal; Ketamine; Male; Pain; Rats; Rats, Inbred Strains; Tail; Viscer | 1991 |
Evidence for a supraspinal mechanism in the opioid-mediated antinociceptive effect of ketamine.
Topics: Analgesics; Animals; Cerebral Ventricles; Injections, Intraperitoneal; Injections, Intraventricular; | 1991 |
An analysis of neuronal responses in nucleus centrum medianum to electrical stimulation of the superficial peroneal nerve.
Topics: Action Potentials; Animals; Cats; Electric Stimulation; Electroacupuncture; Ketamine; Morphine; Nerv | 1991 |
Evidence of a role for NMDA receptors in pain perception.
Topics: Humans; Ketamine; Pain; Phencyclidine; Radioligand Assay; Receptors, N-Methyl-D-Aspartate; Receptors | 1990 |
Evidence for spinal N-methyl-D-aspartate receptor involvement in prolonged chemical nociception in the rat.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dibenzocycloheptenes; Dipeptides; Dizocilpine Maleate; Electri | 1990 |
Sedation for pediatric laceration repair.
Topics: Child; Emergency Medicine; Humans; Ketamine; Pain; Wounds, Penetrating | 1991 |
Opiates modify induction of c-fos proto-oncogene in the spinal cord of the rat following noxious stimulation.
Topics: Animals; Immunohistochemistry; Ketamine; Male; Morphine; Naloxone; Pain; Proto-Oncogene Proteins; Pr | 1990 |
N-methyl-D-aspartate receptors mediate responses of rat dorsal horn neurones to hindlimb ischemia.
Topics: Animals; Anterior Horn Cells; Hindlimb; Injections, Spinal; Ischemia; Ketamine; Male; Pain; Physical | 1990 |
[Ketamine infusion for control of pain in patients with advanced cancer].
Topics: Adult; Aged; Aged, 80 and over; Female; Humans; Infusions, Intravenous; Ketamine; Male; Middle Aged; | 1990 |
[Effect of ketamine on acupuncture analgesia].
Topics: Acupuncture Analgesia; Animals; Electroacupuncture; Ketamine; Male; Pain; Rats; Sensory Thresholds | 1989 |
Antagonism of methoxyflurane-induced anesthesia in rats by benzodiazepine inverse agonists.
Topics: Anesthesia; Animals; Azides; Benzodiazepines; Carbolines; Electric Stimulation; Ketamine; Male; Meth | 1989 |
Pain management in the pediatric emergency department.
Topics: Child; Emergency Service, Hospital; Humans; Injections, Intramuscular; Ketamine; Laryngismus; Pain | 1989 |
[Control of pain and anxiety in pedodontics].
Topics: Anesthesia, Dental; Anxiety; Child; Child, Preschool; Diazepam; Humans; Hydroxyzine; Ketamine; Nitro | 1989 |
Pain control during the intensive care phase of burn care.
Topics: Analgesia; Analgesics, Opioid; Burns; Humans; Ketamine; Pain; Pain Management | 1985 |
Comparison of direct and indirect depressant actions of ketamine on dorsal horn cells in rabbits.
Topics: Analgesics; Animals; Bradykinin; Decerebrate State; Efferent Pathways; Ketamine; Male; Naloxone; Neu | 1986 |
[Use of ketamine in emergency medical care].
Topics: Adolescent; Adult; Aged; Child; Female; First Aid; Humans; Ketamine; Male; Middle Aged; Pain | 1988 |
The effects of pentobarbital, fentanyl-droperidol, ketamine-xylazine and ketamine-diazepam on noxious stimulus perception in adult male rats.
Topics: Anesthesia; Anesthetics; Animals; Diazepam; Droperidol; Drug Combinations; Fentanyl; Ketamine; Male; | 1987 |
[Studies on the intrathecal effect of ketamine in primate].
Topics: Analgesics; Animals; Injections, Spinal; Ketamine; Macaca; Pain; Sensory Thresholds; Spinal Cord | 1987 |
Pain management in the child.
Topics: Administration, Topical; Anesthetics, Local; Child; Child, Preschool; Cocaine; Drug Combinations; Em | 1987 |
Alterations in response to somatic pain associated with anaesthesia. XX. Ketamine.
Topics: Analgesia; Analgesics; Anesthesia, General; Atropine; Cyclohexanes; Female; Humans; Ketamine; Opium; | 1971 |