Sleep Apnea, Central

A condition associated with multiple episodes of sleep apnea which are distinguished from obstructive sleep apnea (SLEEP APNEA, OBSTRUCTIVE) by the complete cessation of efforts to breathe. This disorder is associated with dysfunction of central nervous system centers that regulate respiration.

Synonym
Sleep Apnea, Central

Excerpt	Reference
"Central sleep apnea is common in heart failure and contributes to morbidity and mortality."	( Germany, R, 2017)
"Central sleep apnea is prevalent in patients with heart failure, healthy individuals at high altitudes, and chronic opiate users and in the initiation of "mixed" (that is, central plus obstructive apneas)."	( Dempsey, JA, 2019)
"The prevalence of central sleep apnea is high in sleep and pain clinics in the pain:opioids group."	( Arif, AA; Botros, J; Chung, F; Esfahanian, N; Mubashir, T; Nagappa, M; Ryan, CM; Suen, C; Wong, J, 2020)
"Primary central sleep apnea is classified as nonhypercapnic central sleep apnea."	( Chen, BY; Dong, L; Han, X; Wang, J; Wang, Y; Zhao, D, 2022)

Excerpt	Reference
"Patients with central sleep apnea have a diminished cerebrovascular response to PET(CO(2)), especially to hypocapnia."	( Dempsey, JA; Khayat, R; Morgan, B; Russell, D; Skatrud, JB; Xie, A, 2005)

Excerpt	Reference
"The options for treating central sleep apnea in heart failure are limited and include theophylline."	( Andreas, S; Delekat, A; Grunewald, RW; Hasenfuss, G; Lüthje, L; Reiter, H; Somers, VK, 2004)
"We investigated whether treatment of central sleep apnea-hypopnea with bilevel positive airway pressure (BPAP) in ambulatory patients with idiopathic dilated cardiomyopathy (IDCM) might improve LV function."	( Asano, H; Hirashiki, A; Iino, S; Izawa, H; Koike, Y; Murase, Y; Murohara, T; Nagata, K; Nakata, S; Noda, A; Yokota, M, 2007)
"Adaptive servoventilation as treatment for central sleep apnea due to high-altitude periodic breathing in nonacclimatized healthy individuals."	( Anza-Ramirez, C; Deyoung, PN; Djokic, M; Gilbertson, D; Heinrich, EC; Malhotra, A; Orr, JE; Powell, FL; Simonson, T; Villafuerte, FC, 2018)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	2 (0.54)	23.3326
1990's	3 (0.82)	12.5806
2000's	133 (36.14)	18.1394
2010's	179 (48.64)	28.8240
2020's	51 (13.86)	9.53

Drug	Relationship Strength	Studies	Trials
acetic acid	low	1	0
adenine	low	1	0
carbon monoxide	low	2	0
methane	low	1	0
hydrogen sulfide	low	1	0
lactic acid	low	1	0
hydrogen carbonate	low	1	0
hydroxylamine	low	1	0
melatonin	low	1	0
nitrous oxide	low	2	0
pyridoxal	low	1	0
vanillin	low	1	0
8-hydroxy-2-(di-n-propylamino)tetralin	low	1	0
acetazolamide	medium	16	4
am 251	low	1	0
theophylline	medium	11	1
baclofen	medium	5	1
bupivacaine	low	1	0
buspirone	low	3	0
caffeine	low	7	0
carbamazepine	low	1	0
carvedilol	medium	2	1
chlorpyrifos	medium	1	1
clonazepam	low	2	0
clonidine	medium	4	1
diazoxide	low	1	0
dichlorvos	low	1	0
doxapram	low	1	0
fentanyl	low	2	0
hydroxyzine	low	1	0
ibuprofen	low	1	0
indomethacin	medium	1	1
isoflurane	low	1	0
ketamine	low	1	0
nordefrin	low	1	0
methadone	low	7	0
mianserin	low	2	0
mirtazapine	low	2	0
apnea	low	29	0
neostigmine	low	1	0
propofol	low	3	0
sevoflurane	low	2	0
succinylcholine	low	1	0
temazepam	medium	1	1
nikethamide	low	1	0
triazolam	low	1	0
trimeprazine	low	1	0
zolpidem	medium	4	2
thyroxine	low	1	0
spironolactone	low	1	0
aldosterone	medium	2	1
alanine	low	4	0
trehalose	low	1	0
pyridostigmine bromide	low	1	0
paraoxon	low	2	0
aminophylline	low	1	0
kainic acid	low	3	0
mustard gas	low	1	0
azomycin	low	1	0
congo red	low	1	0
dronabinol	low	1	0
platinum	medium	1	1
argon	low	1	0
trolamine salicylate	low	1	0
pregnanolone	low	1	0
benzonidazole	low	1	0
tramadol	medium	1	1
almitrine	low	1	0
substance p	low	1	0
paroxetine	low	1	0
fomesafen	low	4	0
finasteride	medium	1	1
clopidogrel	low	1	0
remifentanil	low	1	0
valsartan	low	2	0
3-iodobenzylguanidine	low	2	0
trazodone hydrochloride	low	1	0
telmisartan	medium	1	1
methotrimeprazine	low	1	0
chrysamine g	low	1	0
atropine	low	2	0
lignin	low	1	0
povidone-iodine	low	1	0
tacrolimus	low	1	0
sodium bicarbonate	low	1	0
curcumin	low	1	0
D-fructopyranose	low	1	0
laccase	low	1	0
am 630	low	1	0
bilirubin	low	2	0
misoprostol	low	1	0
phenylephrine hydrochloride	low	2	0
hydrocodone	low	1	0
levetiracetam	low	1	0
nalmefene	low	1	0
oxycodone	low	1	0
topiramate	low	1	0
morphine	medium	8	1
dexmedetomidine	low	1	0
naltrexone	low	1	0
pregabalin	low	1	0
tanespimycin	low	1	0
etonogestrel	low	2	0
ticagrelor	low	6	0
prasugrel hydrochloride	low	1	0
buprenorphine, naloxone drug combination	low	1	0
losartan potassium	low	2	0
technetium tc 99m exametazime	low	1	0
jaw	low	1	0
atrial natriuretic factor	medium	5	2
oligonucleotides	low	1	0
endothelin-1	medium	2	1
sodium oxybate	low	3	0
cardiovascular agents	medium	4	3
piperidines	low	2	0
natriuretic peptide, brain	medium	17	6
gal021	low	1	0
nusinersen	low	1	0
exudates	low	2	0
pralidoxime	low	2	0
eye	low	1	0
leptin	low	4	0

Protein Targets (1,061)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
dopamine D1 receptor	2	0	0	2
thioredoxin reductase	18	0	0	18
GLS protein	16	0	0	16
Thrombopoietin	1	0	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	9	0	0	9
cytochrome P450 2D6 isoform 1	10	0	0	10
cytochrome P450 2C19 precursor	6	0	0	6
ras-related protein Rab-9A	5	0	0	5
histone acetyltransferase KAT2A isoform 1	7	0	0	7
lethal factor (plasmid)	7	0	0	7
POU domain, class 2, transcription factor 1	0	0	0	1
Spike glycoprotein	20	0	2	22
ATP-dependent phosphofructokinase	14	0	0	14
phosphopantetheinyl transferase	14	0	0	14
euchromatic histone-lysine N-methyltransferase 2	35	0	0	35
mu-type opioid receptor isoform MOR-1	0	0	3	3
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	4	0	0	4
5-hydroxytryptamine receptor 2A	0	0	3	3
Gamma-aminobutyric acid receptor subunit pi	14	9	2	25
Cytochrome P450 3A4	0	8	1	10
5-hydroxytryptamine receptor 1A	0	12	7	20
5-hydroxytryptamine receptor 2C	0	11	0	11
Neuronal acetylcholine receptor subunit alpha-4	3	3	0	6
Cytochrome P450 2C9	0	10	0	11
Neuronal acetylcholine receptor subunit beta-2	3	3	0	6
D(2) dopamine receptor	0	16	1	20
5-hydroxytryptamine receptor 2A	0	11	0	13
Gamma-aminobutyric acid receptor subunit beta-1	14	9	2	25
Alpha-1B adrenergic receptor	0	15	4	19
Translocator protein	0	3	1	4
Gamma-aminobutyric acid receptor subunit delta	14	9	2	25
Gamma-aminobutyric acid receptor subunit gamma-2	14	9	3	26
D	0	8	0	8
D(3) dopamine receptor	0	8	0	8
5-hydroxytryptamine receptor 1A	0	15	1	18
Alpha-2B adrenergic receptor	0	11	2	14
Gamma-aminobutyric acid receptor subunit alpha-5	14	9	2	25
Gamma-aminobutyric acid receptor subunit alpha-3	14	9	2	25
D(2) dopamine receptor	0	4	0	4
Alpha-2C adrenergic receptor	0	11	2	14
Alpha-2A adrenergic receptor	0	11	2	14
Gamma-aminobutyric acid receptor subunit gamma-1	14	9	2	25
Gamma-aminobutyric acid receptor subunit alpha-2	14	9	2	25
Alpha-1D adrenergic receptor	0	15	4	20
Sodium-dependent dopamine transporter	0	8	1	9
Alpha-1D adrenergic receptor	0	15	1	17
5-hydroxytryptamine receptor 1D	0	2	0	3
5-hydroxytryptamine receptor 1B	0	1	1	2
5-hydroxytryptamine receptor 2C	0	15	1	16
Gamma-aminobutyric acid receptor subunit alpha-4	14	9	2	25
Gamma-aminobutyric acid receptor subunit gamma-3	14	9	2	25
5-hydroxytryptamine receptor 1B	0	11	0	12
5-hydroxytryptamine receptor 1D	0	6	0	7
Gamma-aminobutyric acid receptor subunit alpha-6	14	9	2	25
5-hydroxytryptamine receptor 1F	0	6	0	7
5-hydroxytryptamine receptor 2B	0	9	1	10
Sodium-dependent serotonin transporter	0	10	1	11
5-hydroxytryptamine receptor 7	0	5	0	5
5-hydroxytryptamine receptor 7	0	7	0	7
Alpha-1A adrenergic receptor	0	7	1	9
Alpha-1B adrenergic receptor	0	4	1	6
5-hydroxytryptamine receptor 3A	0	4	0	4
Alpha-1A adrenergic receptor	0	16	5	21
5-hydroxytryptamine receptor 5A	0	2	0	2
5-hydroxytryptamine receptor 6	0	9	0	11
5-hydroxytryptamine receptor 7	0	4	0	4
D(2) dopamine receptor	0	13	1	14
Gamma-aminobutyric acid receptor subunit alpha-1	14	9	3	26
Gamma-aminobutyric acid receptor subunit beta-3	14	9	2	25
Gamma-aminobutyric acid receptor subunit beta-2	14	9	3	26
D	0	2	0	2
5-hydroxytryptamine receptor 2A	0	2	0	2
GABA theta subunit	14	9	2	25
Sigma non-opioid intracellular receptor 1	0	11	0	11
Gamma-aminobutyric acid receptor subunit epsilon	14	9	2	25
5-hydroxytryptamine receptor 3B	0	4	0	4
Lysosomal alpha-glucosidase	0	2	0	2
Transporter	0	8	0	8
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	15	0	0	15
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Beta-lactamase	6	0	0	6
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Class Iii Chitinase Chia1	0	1	0	1
Chain A, Carbonic anhydrase 13	0	1	0	1
Chain A, Carbonic anhydrase II	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase	0	1	0	1
Chain B, Carbonic anhydrase	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase	0	3	0	3
GALC protein	2	0	0	2
GLI family zinc finger 3	24	0	0	24
nuclear receptor subfamily 1, group I, member 3	23	0	0	23
cytochrome P450 family 3 subfamily A polypeptide 4	22	0	0	22
glucocorticoid receptor [Homo sapiens]	34	0	0	34
retinoic acid nuclear receptor alpha variant 1	25	0	0	25
retinoid X nuclear receptor alpha	21	0	0	21
estrogen-related nuclear receptor alpha	34	0	0	34
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase	0	3	0	3
arylsulfatase A	11	0	0	11
Carbonic anhydrase	0	3	0	3
Bloom syndrome protein isoform 1	9	0	0	9
thyroid hormone receptor beta isoform a	12	0	0	12
nuclear factor erythroid 2-related factor 2 isoform 1	25	0	0	25
geminin	30	0	0	30
peripheral myelin protein 22	17	0	0	17
survival motor neuron protein isoform d	4	0	0	4
muscleblind-like protein 1 isoform 1	4	0	0	4
ATP-binding cassette sub-family C member 3	0	30	0	30
Multidrug resistance-associated protein 4	0	30	0	30
Carbonic anhydrase	0	2	0	2
Solute carrier family 22 member 6	0	3	0	3
Carbonic anhydrase 12	0	4	1	9
Prolyl endopeptidase	0	2	0	2
Carbonic anhydrase-related protein 11	0	1	0	3
Bile salt export pump	0	41	0	41
Glycogen phosphorylase, muscle form	0	2	0	2
Renin	0	4	0	4
Carbonic anhydrase 1	0	11	1	20
Carbonic anhydrase 2	0	11	2	20
Carbonic anhydrase 2	0	2	0	2
Cytochrome P450 1A2	0	3	0	3
Carbonic anhydrase 3	0	4	1	8
Cathepsin B	0	1	0	1
Steryl-sulfatase	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	3	0	3
Cytochrome P450 2C8	0	3	0	3
Cytochrome P450 2D6	0	8	0	10
Cytochrome P450 2A6	0	2	0	2
Androgen receptor	0	8	0	9
Cannabinoid receptor 1	0	4	1	5
Arachidonate 5-lipoxygenase-activating protein	0	2	0	2
Cytochrome P450 2B6	0	3	1	4
Carbonic anhydrase 4	0	7	1	11
Carbonic anhydrase 6	0	5	1	9
Carbonic anhydrase 5A, mitochondrial	0	2	0	2
Adenosine receptor A1	0	8	0	11
Serum paraoxonase/arylesterase 1	0	2	0	2
Dipeptidyl peptidase 4	0	0	0	1
Endochitinase	0	1	0	1
Adenosine receptor A2a	0	6	1	12
Delta-type opioid receptor	0	10	2	15
Cytochrome P450 2C19	0	6	0	7
Delta-type opioid receptor	0	11	4	16
Mu-type opioid receptor	0	14	5	22
Carbonic anhydrase 5A, mitochondrial	0	6	2	12
Carbonic anhydrase	0	5	0	6
Kappa-type opioid receptor	0	12	1	14
Carbonic anhydrase 7	0	5	1	9
Carbonic anhydrase	0	1	0	1
D(1A) dopamine receptor	2	1	0	3
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
Carbonic anhydrase	0	2	0	3
Cholinesterase	0	4	0	4
Carbonic anhydrase	0	2	0	2
Mu-type opioid receptor	0	12	2	15
Fatty-acid amide hydrolase 1	0	3	0	3
Beta-carbonic anhydrase 1	0	2	0	2
Carbonic anhydrase 2	0	2	0	2
Glutamate receptor ionotropic, NMDA 2B	0	6	1	8
Squalene synthase	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-7	0	3	0	3
Carbonic anhydrase 9	0	6	1	11
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase, alpha family	0	3	0	3
Carbonic anhydrase	0	2	0	3
Carbonic anhydrase 3	0	1	0	1
Carbonic anhydrase	0	3	0	5
Carbonic anhydrase	0	2	0	4
Carbonic anhydrase	0	2	0	2
Sigma intracellular receptor 2	0	2	0	2
Delta carbonic anhydrase	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	7	0	7
Renin	0	1	0	1
Carbonic anhydrase	0	2	0	3
Endochitinase A1	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	1
Carbonic anhydrase 13	0	4	1	6
Canalicular multispecific organic anion transporter 1	0	28	0	28
Carbonic anhydrase 4	0	4	0	5
Carbonic anhydrase 15	0	3	0	5
Acidic mammalian chitinase	0	1	0	1
Carbonic anhydrase 13	0	5	0	9
Carbonic anhydrase 7	0	1	0	1
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase 14	0	4	1	9
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 2, isoform A	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	6	1	11
estrogen nuclear receptor alpha	48	0	0	48
Free fatty acid receptor 3	0	0	1	1
Free fatty acid receptor 2	0	1	1	2
Tyrosine-protein kinase Lck	0	1	1	2
Tyrosine-protein kinase Fyn	0	1	1	2
Fibrinogen C domain-containing protein 1	0	1	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	10	0	0	10
Chain A, MTA/SAH nucleosidase	0	1	0	1
Chain A, Ribosome-inactivating protein alpha-trichosanthin	0	0	1	1
Chain A, Ricin A chain	0	0	1	1
Chain A, Ribosome-inactivating protein 3	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
RAR-related orphan receptor gamma	29	0	0	29
TDP1 protein	32	0	0	32
AR protein	41	0	0	41
pregnane X nuclear receptor	33	0	0	33
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	19	0	0	19
nuclear factor erythroid 2-related factor 2 isoform 2	5	0	0	5
heat shock protein beta-1	9	0	0	9
importin subunit beta-1 isoform 1	6	0	0	6
snurportin-1	6	0	0	6
tumor susceptibility gene 101 protein	2	0	0	2
GTP-binding nuclear protein Ran isoform 1	3	0	0	3
lamin isoform A-delta10	30	0	0	30
Voltage-dependent calcium channel gamma-2 subunit	12	0	0	12
Cyclin-dependent kinase 1	0	1	0	1
Heat shock protein HSP 90-beta	0	3	2	7
Glutamate receptor 2	12	2	2	18
Xanthine dehydrogenase/oxidase	0	1	0	1
TAR DNA-binding protein 43	7	0	0	7
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
Leucine-rich repeat serine/threonine-protein kinase 2	0	2	0	2
ATPase family AAA domain-containing protein 5	13	0	0	13
Ataxin-2	15	0	0	15
Alanine racemase, biosynthetic	0	0	0	1
Glutamate receptor ionotropic, NMDA 1	0	5	1	7
Proton-coupled amino acid transporter 1	0	1	0	1
Adenosine deaminase	0	0	0	1
Sex hormone-binding globulin	0	0	3	3
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	0	3	2	6
Mineralocorticoid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	1	0	2
Guanine nucleotide-binding protein G	5	0	0	5
Microtubule-associated protein tau	13	0	0	13
regulator of G-protein signaling 4	9	0	0	9
bromodomain adjacent to zinc finger domain 2B	7	0	0	7
cytochrome P450 2C9 precursor	7	0	0	7
cytochrome P450 3A4 isoform 1	14	0	0	14
neuropeptide S receptor isoform A	7	0	0	7
Cannabinoid receptor 1	0	5	2	8
Cannabinoid receptor 2	0	5	2	8
Histamine H2 receptor	9	1	0	13
Chain A, ATP-DEPENDENT DNA HELICASE Q1	3	0	0	3
Chain A, Cruzipain	6	0	0	6
Fumarate hydratase	5	0	0	5
USP1 protein, partial	15	0	0	15
PPM1D protein	3	0	0	3
aldehyde dehydrogenase 1 family, member A1	15	0	0	15
thyroid stimulating hormone receptor	10	0	0	10
EWS/FLI fusion protein	16	0	0	17
polyprotein	5	0	0	5
cellular tumor antigen p53 isoform a	5	0	0	5
Polyunsaturated fatty acid lipoxygenase ALOX15B	3	0	0	3
Interferon beta	11	0	0	11
Integrin beta-3	3	0	0	3
Integrin alpha-IIb	3	0	0	3
Cannabinoid receptor 2	0	1	2	3
Inositol monophosphatase 1	7	0	0	7
ATAD5 protein, partial	12	0	0	12
D(1A) dopamine receptor	10	0	0	10
Chain A, JmjC domain-containing histone demethylation protein 3A	6	0	0	6
5-hydroxytryptamine receptor 3E	0	4	0	4
acetylcholinesterase	14	0	0	14
hypoxia-inducible factor 1 alpha subunit	11	0	0	11
SMAD family member 2	7	0	0	7
SMAD family member 3	7	0	0	7
estrogen receptor 2 (ER beta)	11	0	0	11
progesterone receptor	14	0	0	14
farnesoid X nuclear receptor	13	0	0	13
G	9	0	0	9
cytochrome P450 2D6	15	0	0	15
67.9K protein	6	0	0	6
peroxisome proliferator-activated receptor delta	9	0	0	9
peroxisome proliferator activated receptor gamma	18	0	0	18
vitamin D (1,25- dihydroxyvitamin D3) receptor	16	0	0	16
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	4	0	0	4
thyroid stimulating hormone receptor	9	0	0	9
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	11	0	0	11
v-jun sarcoma virus 17 oncogene homolog (avian)	10	0	0	10
lysosomal alpha-glucosidase preproprotein	4	0	0	4
potassium voltage-gated channel subfamily H member 2 isoform d	13	0	0	13
transcriptional regulator ERG isoform 3	4	0	0	4
thyroid hormone receptor beta isoform 2	27	0	0	27
nuclear receptor ROR-gamma isoform 1	14	0	0	14
Solute carrier family 22 member 2	0	3	0	3
5-hydroxytryptamine receptor 3A	0	2	1	3
5-hydroxytryptamine receptor 3B	0	4	0	4
HLA class I histocompatibility antigen, B alpha chain	9	0	0	9
Cellular tumor antigen p53	26	0	0	26
ATP-dependent translocase ABCB1	0	8	0	9
Alpha-2C adrenergic receptor	0	12	2	14
Muscarinic acetylcholine receptor M3	0	9	2	13
D(1A) dopamine receptor	0	7	0	8
D(4) dopamine receptor	0	7	0	9
D(1B) dopamine receptor	0	2	0	3
5-hydroxytryptamine receptor 2A	0	12	0	14
D(4) dopamine receptor	0	5	0	5
Histamine H1 receptor	0	2	0	2
Sodium-dependent serotonin transporter	0	11	1	12
Histamine H1 receptor	0	9	2	13
D(3) dopamine receptor	0	12	2	16
5-hydroxytryptamine receptor 2B	0	11	1	12
5-hydroxytryptamine receptor 3A	0	6	0	6
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	2	0	2
Potassium voltage-gated channel subfamily H member 2	0	16	0	16
5-hydroxytryptamine receptor 3D	0	4	0	4
Multidrug and toxin extrusion protein 2	0	2	0	2
5-hydroxytryptamine receptor 3C	0	4	0	4
Inositol hexakisphosphate kinase 1	9	0	0	9
Multidrug and toxin extrusion protein 1	0	7	0	7
Histamine H3 receptor	0	3	0	3
cytochrome P450 2C9, partial	9	0	0	9
Atrial natriuretic peptide receptor 1	0	1	1	2
Atrial natriuretic peptide receptor 1	0	0	1	1
Chain A, 2-oxoglutarate Oxygenase	13	0	0	13
cystic fibrosis transmembrane conductance regulator	0	1	0	1
DNA polymerase beta	5	0	0	5
short transient receptor potential channel 6 isoform 1	0	0	3	3
Solute carrier family 22 member 1	0	11	0	12
5-hydroxytryptamine receptor 4	0	10	0	10
Muscarinic acetylcholine receptor M2	0	8	2	13
Muscarinic acetylcholine receptor M4	0	8	2	12
Muscarinic acetylcholine receptor M1	0	6	1	9
Muscarinic acetylcholine receptor M3	0	6	1	9
Muscarinic acetylcholine receptor M4	0	6	1	9
Muscarinic acetylcholine receptor M5	0	7	1	10
Muscarinic acetylcholine receptor M5	0	8	1	11
Muscarinic acetylcholine receptor M2	0	6	1	10
Muscarinic acetylcholine receptor M1	0	8	2	13
Muscarinic acetylcholine receptor M1	0	0	0	1
Muscarinic acetylcholine receptor M4	0	1	0	1
Reverse transcriptase/RNaseH	0	0	0	1
Muscarinic acetylcholine receptor	0	1	1	3
NFKB1 protein, partial	4	0	0	4
activating transcription factor 6	11	0	0	11
Gamma-aminobutyric acid type B receptor subunit 2	0	2	1	3
Gamma-aminobutyric acid type B receptor subunit 2	0	2	0	2
Gamma-aminobutyric acid type B receptor subunit 1	0	2	1	3
Gamma-aminobutyric acid type B receptor subunit 1	0	1	0	1
Glyceraldehyde-3-phosphate dehydrogenase	0	1	0	1
Aurora kinase B	0	1	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	5	0	0	5
Chain A, HADH2 protein	9	0	0	9
Chain B, HADH2 protein	9	0	0	9
vitamin D3 receptor isoform VDRA	8	0	0	8
DNA polymerase kappa isoform 1	13	0	0	13
caspase-1 isoform alpha precursor	2	0	0	2
Caspase-7	2	0	0	2
Solute carrier organic anion transporter family member 1B3	0	6	0	7
Solute carrier organic anion transporter family member 1B1	0	7	0	9
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 3	0	2	0	2
Potassium channel subfamily K member 2	0	1	3	4
Potassium channel subfamily K member 9	0	2	0	2
Kappa-type opioid receptor	0	13	5	24
chromobox protein homolog 1	17	0	0	17
muscarinic acetylcholine receptor M1	9	0	0	9
Bile salt export pump	0	5	0	5
Beta-2 adrenergic receptor	0	3	0	3
Angiotensin-converting enzyme	0	2	0	2
Beta-1 adrenergic receptor	0	2	0	2
D(1B) dopamine receptor	0	4	0	4
Beta-3 adrenergic receptor	0	2	0	2
Alpha-2A adrenergic receptor	0	2	0	2
D	0	3	0	3
Chain A, Glycogen Phosphorylase	0	1	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Chitinase	0	1	0	1
atrial natriuretic peptide receptor 1 precursor	2	0	0	2
Cholinesterase	0	8	0	8
Glycogen phosphorylase, liver form	0	1	0	1
Glycogen phosphorylase, muscle form	0	1	0	1
Replicase polyprotein 1ab	0	3	3	6
Adenosine receptor A3	0	2	0	2
Replicase polyprotein 1ab	0	3	3	6
Amine oxidase [flavin-containing] A	0	5	0	5
Acetylcholinesterase	0	10	0	10
Amine oxidase [flavin-containing] B	0	6	0	6
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	3	0	3
Adenosine receptor A3	0	2	0	2
Adenosine receptor A2a	0	4	3	9
Adenosine receptor A2b	0	2	0	4
Adenosine receptor A2b	0	3	1	6
Adenosine receptor A1	0	4	2	10
Vasopressin V2 receptor	0	0	0	2
Serine/threonine-protein kinase mTOR	0	2	0	2
Adenosine receptor A2a	0	2	0	2
Adenosine receptor A1	0	2	0	2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	2	0	2
DNA-dependent protein kinase catalytic subunit	0	3	0	3
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Adenylate cyclase type 1	0	0	0	2
Chitotriosidase-1	0	2	0	2
Serine-protein kinase ATM	0	1	0	1
Serine/threonine-protein kinase ATR	0	1	0	1
Adenosine receptor A2b	0	1	0	3
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	2	3	5
Endochitinase B1	0	2	0	2
Phosphodiesterase	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	4	0	4
Guanine deaminase	0	1	0	1
IDH1	9	0	0	9
mitogen-activated protein kinase 1	7	0	0	7
Vpr	3	0	0	3
Albumin	0	0	3	3
Major prion protein	0	0	1	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	2	0	2
Sodium channel protein type 3 subunit alpha	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	1	0	5
Sodium channel protein type 4 subunit alpha	0	2	0	3
Cytochrome P450 2J2	0	6	0	7
Sodium channel protein type 9 subunit alpha	0	2	0	2
Frizzled-8	0	0	1	1
P2X purinoceptor 4	0	2	0	2
Chain A, serum paraoxonase	0	1	0	1
Neutrophil cytosol factor 1	0	1	0	1
Poly [ADP-ribose] polymerase tankyrase-2	0	1	0	1
serine/threonine-protein kinase mTOR isoform 1	4	0	0	4
histone-lysine N-methyltransferase 2A isoform 2 precursor	2	0	0	2
Toll-like receptor 4	0	1	0	1
Amyloid-beta precursor protein	0	5	0	6
Beta-2 adrenergic receptor	0	2	1	3
Aldo-keto reductase family 1 member B1	0	11	0	11
Beta-1 adrenergic receptor	0	2	1	3
Alpha-2A adrenergic receptor	0	11	3	14
Angiotensin-converting enzyme	0	6	0	6
Beta-3 adrenergic receptor	0	2	1	3
Alpha-2B adrenergic receptor	0	9	1	10
UDP-glucuronosyltransferase 1A1	0	2	0	3
Sodium-dependent noradrenaline transporter	0	12	1	13
Potassium channel subfamily K member 10	0	1	0	1
Sodium-dependent dopamine transporter	0	5	1	6
Cytochrome P450 1B1	0	2	0	2
Nuclear receptor subfamily 3 group C member 3	0	6	0	6
15-lipoxygenase, partial	5	0	0	5
PINK1	2	0	0	2
Parkin	3	0	0	3
aryl hydrocarbon receptor	11	0	0	11
Histone H2A.x	10	0	0	10
Caspase-7	1	0	0	1
serine-protein kinase ATM isoform a	1	0	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	2	0	0	2
prostaglandin E2 receptor EP2 subtype	0	0	0	1
caspase-3	1	0	0	1
serine/threonine-protein kinase PLK1	2	0	0	2
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
Acetylcholinesterase	0	1	0	1
Nuclear receptor ROR-gamma	7	0	0	7
Carboxylic ester hydrolase	0	1	0	1
Rap guanine nucleotide exchange factor 4	2	0	0	2
ORF73	0	0	1	1
Type-2 angiotensin II receptor	0	5	0	5
Angiotensin-converting enzyme	0	3	0	3
Type-2 angiotensin II receptor	0	3	0	3
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	1	0	1
7-dehydrocholesterol reductase	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	0	3	0	3
Gamma-aminobutyric acid receptor subunit delta	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	3
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	3
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	3
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	3
Gamma-aminobutyric acid receptor subunit alpha-1	0	6	3	9
Gamma-aminobutyric acid receptor subunit beta-1	0	4	1	5
Gamma-aminobutyric acid receptor subunit gamma-2	0	6	2	8
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	3
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	3
Gamma-aminobutyric acid receptor subunit beta-3	0	6	1	7
Translocator protein	0	1	0	1
Translocator protein	0	2	0	2
Cholecystokinin receptor type A	0	2	0	2
Gastrin/cholecystokinin type B receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	5	3	8
Gamma-aminobutyric acid receptor subunit alpha-3	0	5	2	7
Gamma-aminobutyric acid receptor subunit alpha-2	0	5	2	7
Gamma-aminobutyric acid receptor subunit beta-2	0	4	2	6
Gamma-aminobutyric acid receptor subunit alpha-4	0	4	1	5
Gamma-aminobutyric acid receptor subunit epsilon	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-6	0	5	1	6
Gamma-aminobutyric acid receptor subunit gamma-1	0	3	0	3
Gamma-aminobutyric acid receptor subunit gamma-3	0	3	0	3
Gamma-aminobutyric acid receptor subunit theta	0	3	0	3
Chain A, Ferritin light chain	7	0	0	7
Beta-1 adrenergic receptor	0	1	1	2
Alpha-1B adrenergic receptor	0	0	2	2
Membrane primary amine oxidase	0	1	0	1
Solute carrier family 22 member 3	0	2	0	2
Alpha-1A adrenergic receptor	0	0	2	2
Alpha-2B adrenergic receptor	0	0	0	1
Alpha-2C adrenergic receptor	0	0	0	1
Alpha-2A adrenergic receptor	0	0	0	1
Nischarin	0	2	0	2
Solute carrier family 22 member 1	0	1	0	1
Nischarin	0	1	0	1
nonstructural protein 1	2	0	0	2
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	3	0	0	3
Liver carboxylesterase 1	0	1	0	2
P2Y purinoceptor 12	0	3	0	3
Luciferase	13	0	0	13
caspase 7, apoptosis-related cysteine protease	4	0	0	4
glucocerebrosidase	3	0	0	3
caspase-3	4	0	0	4
Adenylate cyclase type 1	0	1	0	1
peripheral myelin protein 22 isoform 1	3	0	0	3
atrial natriuretic peptide receptor 2 precursor	2	0	0	2
DNA polymerase iota isoform a (long)	5	0	0	5
M-phase phosphoprotein 8	6	0	0	6
transient receptor potential cation channel subfamily V member 1	1	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	3	0	3
Calmodulin-1	0	1	0	1
Endothelin receptor type B	0	2	0	2
Adenylate cyclase type 3	0	1	0	1
UDP-glucuronosyltransferase 1A4	0	0	0	2
5-hydroxytryptamine receptor 3A	0	3	0	3
Endothelin receptor type B	0	2	0	2
Histamine H2 receptor	0	4	0	4
Adenylate cyclase type 2	0	1	0	1
Adenylate cyclase type 4	0	1	0	1
Histamine H1 receptor	0	3	0	3
5-hydroxytryptamine receptor 2C	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
Adenylate cyclase type 8	0	1	0	1
D(2) dopamine receptor	0	1	0	1
D(3) dopamine receptor	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
D(2) dopamine receptor	0	1	0	1
Calmodulin	0	0	1	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	3	0	3
5-hydroxytryptamine receptor 2B	0	1	0	1
Adenylate cyclase type 6	0	1	0	1
Adenylate cyclase type 5	0	1	0	1
5-hydroxytryptamine receptor 4	0	1	1	2
Voltage-dependent L-type calcium channel subunit alpha-1S	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1C	0	3	0	3
Transporter	0	1	0	1
Cholecystokinin receptor type A	0	2	0	2
5-hydroxytryptamine receptor 1A	0	2	0	2
Adenylyl cyclase 7	0	1	0	1
Histamine H4 receptor	0	2	1	3
Sigma non-opioid intracellular receptor 1	0	3	0	3
B2 bradykinin receptor	0	1	0	1
Dihydrofolate reductase	0	1	0	2
Dihydrofolate reductase	0	1	0	1
Chymotrypsinogen A	0	1	0	2
Beta-lactamase	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-galactosidase	0	1	0	2
Choline O-acetyltransferase	0	1	0	1
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2	0	2	0	2
PH domain leucine-rich repeat-containing protein phosphatase 2	0	1	0	1
Chymotrypsin-C	0	1	0	1
Chain A, Breast cancer type 1 susceptibility protein	1	0	0	1
interleukin 8	4	0	0	4
Nrf2	1	0	0	1
pregnane X receptor	4	0	0	4
alkaline phosphatase, intestinal	0	1	0	1
thioredoxin glutathione reductase	2	0	0	2
Smad3	3	0	0	3
apical membrane antigen 1, AMA1	3	0	0	3
toll-like receptor 9	0	1	0	1
TPA: protein transporter TIM10	0	1	0	1
thyrotropin-releasing hormone receptor	1	0	0	1
alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein	0	1	0	1
hemoglobin subunit beta	1	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	8	0	0	8
perilipin-5	0	1	0	1
intestinal alkaline phosphatase precursor	0	1	0	1
perilipin-1	0	1	0	1
huntingtin isoform 2	2	0	0	2
pyruvate kinase PKM isoform a	1	0	0	1
nuclear factor NF-kappa-B p105 subunit isoform 1	2	0	0	2
flap endonuclease 1	3	0	0	3
urokinase-type plasminogen activator precursor	1	0	0	1
plasminogen precursor	1	0	0	1
urokinase plasminogen activator surface receptor precursor	1	0	0	1
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	0	0	1
alkaline phosphatase, germ cell type preproprotein	0	1	0	1
hypothetical protein SA1422	0	1	0	1
DNA dC->dU-editing enzyme APOBEC-3F isoform a	1	0	0	1
Prostaglandin E synthase	0	2	0	2
Histone deacetylase 3	0	4	0	4
Acetylcholinesterase	0	5	1	6
Lysine-specific histone demethylase 1A	0	1	0	1
D-amino-acid oxidase	0	1	0	1
Phospholipase A2	0	1	0	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	2	0	2
Neuronal proto-oncogene tyrosine-protein kinase Src	0	1	0	1
Prostaglandin G/H synthase 1	0	5	0	6
Heme oxygenase 1	0	1	0	1
Glutathione S-transferase P	0	1	0	1
60 kDa chaperonin	0	1	0	1
Microtubule-associated protein tau	0	1	0	2
60 kDa heat shock protein, mitochondrial	0	1	0	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2	0	1	0	1
Tissue factor	0	3	0	3
Tyrosinase	0	2	0	2
Aminopeptidase N	0	1	0	1
Aminopeptidase N	0	1	0	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2	0	2	0	2
Glycogen synthase kinase-3 beta	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Heme oxygenase 2	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Proteasome subunit beta type-5	0	1	0	1
Prostaglandin G/H synthase 2	0	4	1	5
17-beta-hydroxysteroid dehydrogenase type 2	0	1	0	1
Alpha-synuclein	1	1	1	3
Glycogen synthase kinase-3 beta	0	1	0	1
Histone deacetylase 4	0	4	0	4
Beta-secretase 1	0	1	0	1
10 kDa heat shock protein, mitochondrial	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Lactoylglutathione lyase	0	2	0	2
Histone acetyltransferase p300	0	1	0	1
Serine/threonine-protein kinase PAK 1	0	1	0	1
Histone deacetylase 1	0	5	0	5
Sodium/bile acid cotransporter	0	0	1	1
Nuclear factor erythroid 2-related factor 2	0	0	1	2
Thiosulfate sulfurtransferase	0	1	0	1
Thioredoxin reductase 1, cytoplasmic	0	1	0	1
60 kDa chaperonin	0	1	0	1
10 kDa chaperonin	0	1	0	1
Thioredoxin reductase 3	0	1	0	1
Sortase A	0	1	0	1
Histone deacetylase 7	0	4	0	4
Histone deacetylase 2	0	5	0	5
CREB-binding protein	0	1	0	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3	0	2	0	2
Cysteine protease	0	1	0	1
Polyamine deacetylase HDAC10	0	4	0	4
Histone deacetylase 11	0	4	0	4
NACHT, LRR and PYD domains-containing protein 3	0	1	0	1
Histone deacetylase 8	0	5	0	5
Thioredoxin reductase 2, mitochondrial	0	1	0	1
CDGSH iron-sulfur domain-containing protein 1	0	2	0	2
Histone deacetylase 6	0	4	0	4
Histone deacetylase 9	0	4	0	4
Histone deacetylase 5	0	4	0	4
Lymphocyte antigen 96	0	0	1	1
Beta lactamase (plasmid)	0	1	0	1
Coagulation factor VII	0	1	0	1
Glutamate receptor 1	0	2	2	6
Glutamate receptor 3	0	2	2	6
Glutamate receptor 4	0	2	2	6
Nicotinamide phosphoribosyltransferase	0	0	1	1
ATP-binding cassette sub-family C member 8	0	1	1	2
ATP-sensitive inward rectifier potassium channel 11	0	1	1	2
Acetylcholinesterase	0	1	0	1
Fatty-acid amide hydrolase 1	0	2	0	2
Nuclear receptor subfamily 1 group I member 2	0	0	4	4
Transient receptor potential cation channel subfamily A member 1	0	0	0	1
L-lactate dehydrogenase A chain	0	1	0	1
Fatty acid-binding protein, liver	0	1	0	1
Glycine receptor subunit alpha-1	0	0	2	2
Cannabinoid receptor 1	0	1	0	1
N-arachidonyl glycine receptor	0	0	1	1
Transient receptor potential cation channel subfamily A member 1	0	0	2	2
Lysophosphatidylserine lipase ABHD12	0	1	0	1
Monoglyceride lipase	0	1	0	1
Monoacylglycerol lipase ABHD6	0	1	0	1
Cannabinoid receptor 2	0	2	0	2
G-protein coupled receptor 55	0	1	1	2
Endothelin-1 receptor	0	2	0	2
nuclear receptor subfamily 1, group I, member 2	1	0	0	1
Kappa-type opioid receptor	0	7	4	12
Mu-type opioid receptor	0	14	8	27
Delta-type opioid receptor	0	11	6	22
Mu-type opioid receptor	0	6	3	13
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1	0	1	0	1
3-oxo-5-alpha-steroid 4-dehydrogenase 1	0	2	0	2
3-oxo-5-alpha-steroid 4-dehydrogenase 1	0	2	0	2
3-oxo-5-alpha-steroid 4-dehydrogenase 2	0	1	0	1
3-oxo-5-alpha-steroid 4-dehydrogenase 2	0	2	0	2
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase	0	1	0	1
Mas-related G-protein coupled receptor member X2	0	0	4	4
Single-stranded DNA cytosine deaminase	1	0	0	1
Spike glycoprotein	0	0	2	2
Replicase polyprotein 1ab	0	0	2	2
Transmembrane protease serine 2	0	0	2	2
Procathepsin L	0	1	2	3
Replicase polyprotein 1a	0	0	2	2
Replicase polyprotein 1ab	0	0	2	2
Angiotensin-converting enzyme 2	0	0	2	2
Acid-sensing ion channel 3	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	1	0	2
Prostaglandin G/H synthase 1	0	2	0	3
Prostaglandin G/H synthase 2	0	2	0	3
Epidermal growth factor receptor	0	3	0	3
Fatty acid-binding protein, liver	0	1	0	1
Albumin	0	2	3	5
Albumin	0	1	0	1
Fatty acid-binding protein, intestinal	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	2	0	4
Prostaglandin G/H synthase 1	0	2	0	2
Prostaglandin G/H synthase 1	0	3	0	3
Caspase-1	0	1	0	2
Substance-P receptor	0	3	0	3
Prostaglandin G/H synthase 2	0	2	0	3
UDP-glucuronosyltransferase 1A3	0	0	0	2
Aldo-keto reductase family 1 member C3	0	3	0	3
Caspase-3	0	1	0	1
Caspase-4	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Caspase-5	0	1	0	1
Caspase-9	0	1	0	1
Acid-sensing ion channel 1	0	1	0	1
Prostaglandin G/H synthase 2	0	4	0	4
Prostaglandin G/H synthase 2	0	2	0	3
Solute carrier family 22 member 6	0	2	0	2
Prostaglandin G/H synthase 1	0	2	0	3
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 8	0	2	0	2
Solute carrier family 22 member 6	0	1	0	1
Dehydrogenase/reductase SDR family member 9	0	1	0	1
Chain A, membrane-associated prostaglandin E synthase-2	0	1	0	1
Prostaglandin-H2 D-isomerase	0	1	0	1
3',5'-cyclic-AMP phosphodiesterase	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	2	0	2
Cytochrome c oxidase subunit 2	0	1	0	1
Phospholipase A2, major isoenzyme	0	1	0	1
Interleukin-8	0	1	0	1
Androgen receptor	0	2	2	4
Aldo-keto reductase family 1 member B1	0	1	0	1
Aldo-keto reductase family 1 member B1	0	2	0	2
Aldo-keto reductase family 1 member C4	0	1	0	1
Sodium- and chloride-dependent GABA transporter 1	0	3	0	3
Thromboxane-A synthase	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Nitric oxide synthase, inducible	0	1	0	1
Prostaglandin E2 receptor EP3 subtype	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	3	0	3
Sodium- and chloride-dependent GABA transporter 3	0	3	0	3
Prostaglandin E2 receptor EP4 subtype	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	1
Bifunctional epoxide hydrolase 2	0	1	0	1
Prostaglandin E2 receptor EP1 subtype	0	1	0	1
Peroxisome proliferator-activated receptor gamma	0	1	4	5
Sodium- and chloride-dependent betaine transporter	0	3	0	3
C-X-C chemokine receptor type 3	0	1	0	1
Aldo-keto reductase family 1 member C2	0	1	0	1
Prostaglandin D2 receptor	0	2	0	2
Solute carrier organic anion transporter family member 1A3	0	1	0	2
Aldo-keto reductase family 1 member C1	0	1	0	1
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
Prostaglandin E2 receptor EP2 subtype	0	1	0	1
Rho-associated protein kinase 2	0	1	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Dehydrogenase/reductase SDR family member 9	0	1	0	1
P2Y purinoceptor 12	0	1	0	1
Cytosolic phospholipase A2 gamma	0	1	0	1
Prostaglandin D2 receptor 2	0	1	1	2
Neuronal acetylcholine receptor subunit beta-2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Chain A, Glutamate receptor 2	0	0	1	1
Chain A, Glutamate receptor 2	0	0	1	1
Chain C, Glutamate receptor 2	0	0	1	1
endonuclease IV	3	0	0	3
Metabotropic glutamate receptor 6	0	0	1	1
Glutamate receptor ionotropic, kainate 1	0	2	1	3
Glutamate receptor ionotropic, kainate 1	0	2	1	3
Metabotropic glutamate receptor 5	0	0	1	1
Glutamate receptor ionotropic, kainate 2	0	2	2	4
Glutamate receptor 1	0	1	1	2
Glutamate receptor 2	0	1	1	2
Glutamate receptor 3	0	0	1	1
Glutamate receptor ionotropic, kainate 3	0	2	0	2
Glutamate receptor 4	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	4	1	6
Glutamate receptor ionotropic, NMDA 2C	0	4	1	6
Glutamate receptor ionotropic, kainate 4	0	2	0	2
Glutamate receptor ionotropic, kainate 2	0	2	1	3
Glutamate receptor ionotropic, kainate 3	0	2	0	2
Glutamate receptor ionotropic, kainate 4	0	1	0	1
Glutamate receptor ionotropic, kainate 5	0	2	0	2
Glutamate receptor ionotropic, NMDA 2D	0	4	1	6
Glutamate receptor ionotropic, kainate 5	0	2	0	2
Glutamate receptor ionotropic, NMDA 3B	0	4	1	6
Glutamate receptor ionotropic, NMDA 3A	0	4	1	6
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Rap guanine nucleotide exchange factor 3	2	0	0	2
Glutamate receptor ionotropic, NMDA 1	0	2	0	2
Glutamate receptor ionotropic, NMDA 2A	0	2	0	2
Glutamate receptor ionotropic, NMDA 2B	0	2	0	2
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
Synaptic vesicle glycoprotein 2A	0	1	0	1
WRN	1	0	0	1
integrase, partial	0	1	0	1
lens epithelium-derived growth factor p75	0	1	0	1
pyruvate kinase	1	0	0	1
hexokinase-4 isoform 1	1	0	0	1
glucokinase regulatory protein	1	0	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	2	0	0	2
DNA polymerase eta isoform 1	2	0	0	2
Polyphenol oxidase 2	0	1	0	2
Plasma kallikrein	0	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	2	0	2
Solute carrier family 15 member 1	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	1	0	1
SLC16A10 protein	0	0	0	1
Carbonic anhydrase-like protein, putative	0	0	0	1
Monocarboxylate transporter 10	0	0	0	1
phosphoglycerate kinase	1	0	0	1
Type-1A angiotensin II receptor	0	2	1	3
Type-1B angiotensin II receptor	0	3	0	3
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	2	0	2
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	2	0	2
Type-1 angiotensin II receptor	0	1	0	1
ClpP	1	0	0	1
Cytochrome P450 1A1	0	1	0	1
Cytochrome P450 1A2	0	1	0	1
Myeloperoxidase	0	2	0	2
Cytochrome P450 2C11	0	1	0	1
Aromatase	0	1	0	1
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	2	0	2
Metabotropic glutamate receptor 1	0	1	0	1
Acetylcholinesterase	0	1	0	1
Nociceptin receptor	0	1	0	1
Melatonin receptor type 1A	0	2	1	3
Melatonin receptor type 1C	0	0	1	1
Melatonin receptor type 1A	0	1	1	2
Melatonin receptor type 1B	0	2	1	3
Melatonin receptor type 1C	0	1	1	2
Melatonin receptor type 1B	0	1	1	2
Carboxylic ester hydrolase	0	1	0	1
Aldehyde oxidase 1	0	1	0	1
Snq2p	0	0	0	1
Pleiotropic ABC efflux transporter of multiple drugs	0	1	0	2
5-hydroxytryptamine receptor 6	0	1	0	1
5-hydroxytryptamine receptor 5A	0	1	0	1
5-hydroxytryptamine receptor 5B	0	1	0	1
5-hydroxytryptamine receptor 4	0	1	0	1
5-hydroxytryptamine receptor 3B	0	2	0	2
G-protein coupled receptor	0	1	0	1
glp-1 receptor, partial	4	0	0	4
Opioid receptor, delta 1b	0	1	0	1
Opioid receptor homologue	0	1	0	1
ATP-dependent translocase ABCB1	0	1	0	1
Acyl-CoA desaturase 1	0	1	0	1
Histidine decarboxylase	0	0	3	3
ATP-dependent translocase ABCB1	0	1	0	1
Proteinase-activated receptor 1	0	1	1	2
Kappa-type opioid receptor	0	5	3	10
Nociceptin receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Beta-2 adrenergic receptor	0	2	0	2
Mu-type opioid receptor	0	1	0	1
kappa-type opioid receptor isoform 1	0	1	0	1
Beta-galactosidase	0	0	1	1
UDP-glucuronosyltransferase 1A8	0	0	0	3
Nociceptin receptor	0	1	0	1
D(2) dopamine receptor isoform long	1	0	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
Muscarinic acetylcholine receptor DM1	0	1	0	1
Acetylcholinesterase	0	2	0	2
Xaa-Pro dipeptidase	0	0	0	1
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
Sodium-dependent noradrenaline transporter	0	1	0	1
Quinolone resistance protein NorA	0	1	0	1
Beta-adrenergic receptor kinase 1	0	1	0	1
Potassium voltage-gated channel subfamily A member 3	0	1	0	1
Beta-adrenergic receptor kinase 1	0	1	1	2
Substance-P receptor	0	3	1	4
Rhodopsin kinase GRK1	0	1	0	1
G protein-coupled receptor kinase 5	0	1	0	1
G protein-coupled receptor kinase 5	0	1	0	1
P2X purinoceptor 4	0	1	0	1
Envelope glycoprotein	0	0	1	1
Rhodopsin kinase GRK1	0	1	0	1
Sodium-dependent serotonin transporter	0	1	0	1
Sodium-dependent dopamine transporter	0	1	0	1
Beta-adrenergic receptor kinase 1	0	0	0	1
beta-2 adrenergic receptor	1	0	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	2
Voltage-dependent calcium channel subunit alpha-2/delta-2	0	1	0	1
Gamma-aminobutyric acid	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	0	1	1
Gamma-aminobutyric acid receptor subunit delta	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit beta-1	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	0	1	1
Gamma-aminobutyric acid receptor subunit pi	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	1	1
Gamma-aminobutyric acid receptor subunit theta	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
UDP-glucuronosyltransferase 1A9	0	0	0	2
alpha-galactosidase	1	0	0	1
Pyridoxal kinase	0	0	0	1
Aldehyde oxidase	0	1	0	1
Free fatty acid receptor 3	0	0	1	1
Chain A, Mineralocorticoid receptor	0	1	0	1
Chain A, Mineralocorticoid receptor	0	1	0	1
Estrogen receptor	0	2	1	3
Glucocorticoid receptor	0	2	1	3
Progesterone receptor	0	2	1	3
Glycine receptor subunit alpha-1	0	2	0	2
Glycine receptor subunit beta	0	2	0	2
Glycine receptor subunit alpha-2	0	2	0	2
Glycine receptor subunit alpha-3	0	2	0	2
Estrogen receptor beta	0	1	1	2
Substance-P receptor	0	2	0	2
Neuromedin-K receptor	0	0	1	1
Substance-K receptor	0	1	1	2
Substance-K receptor	0	2	0	2
Neuromedin-K receptor	0	1	1	2
Substance-K receptor	0	1	0	1
Substance-K receptor	0	1	0	1
Growth hormone secretagogue receptor type 1	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Cytochrome P450 3A5	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	2	1	3
Peptidyl-prolyl cis-trans isomerase FKBP1B	0	0	1	1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP5	0	1	0	1
Splicing factor 3B subunit 3	0	1	0	1
Corticotropin releasing hormone receptor 2	0	1	0	1
Lysine-specific demethylase 6B	0	1	0	1
Lysine-specific demethylase 4B	0	1	0	1
Tyrosine-protein kinase ABL1	0	1	0	1
ATP-dependent molecular chaperone HSP82	0	1	0	1
Receptor tyrosine-protein kinase erbB-2	0	1	0	1
Heat shock protein HSP 90-alpha	0	3	2	5
Breakpoint cluster region protein	0	1	0	1
Cholesteryl ester transfer protein	0	0	1	1
ATP-dependent molecular chaperone HSC82	0	1	0	1
Lysine-specific demethylase 5A	0	1	0	1
Endoplasmin	0	1	1	2
Heat shock protein 75 kDa, mitochondrial	0	1	0	1
Heat-shock protein	0	1	0	1
Putative heat shock protein HSP 90-alpha A4	0	1	0	1
Lysine-specific demethylase 4C	0	1	0	1
eyes absent homolog 2 isoform a	1	0	0	1
Cystic fibrosis transmembrane conductance regulator	0	0	1	1
Amine oxidase [flavin-containing] A	0	0	1	1
Thromboxane A2 receptor	0	0	0	2
Peroxisome proliferator-activated receptor alpha	0	0	1	1
Type-1 angiotensin II receptor	0	3	1	6
Peroxisome proliferator-activated receptor delta	0	0	1	1
Peroxisome proliferator-activated receptor gamma	0	0	1	1
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
Peroxisome proliferator-activated receptor delta	0	1	1	2
Peroxisome proliferator-activated receptor alpha	0	1	1	2
Chain A, Pyridoxal kinase	0	1	0	1
Chain A, Pyridoxal Kinase	0	1	0	1
Phosphodiesterase	0	2	0	2
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	2	0	2
Intestinal-type alkaline phosphatase	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Thyroid hormone receptor beta	0	1	0	1
Adenosine receptor A1	0	2	0	2
Adenosine receptor A1	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	2	0	2
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
Phospholipase A-2-activating protein	0	1	0	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Solute carrier organic anion transporter family member 1A5	0	0	0	1
Transthyretin	0	1	0	2
Thyroid hormone receptor alpha	0	0	1	1
Thyroid hormone receptor beta	0	0	1	1
Proliferating cell nuclear antigen	0	1	0	1
Retinoic acid receptor RXR-alpha	0	0	2	2
Malate dehydrogenase, mitochondrial	0	1	0	1
Solute carrier organic anion transporter family member 1A2	0	0	0	1
Solute carrier organic anion transporter family member 4C1	0	1	0	1
Monocarboxylate transporter 8	0	0	0	1
Bile acid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1C1	0	0	0	1
P2Y purinoceptor 13	0	1	0	1
Chain A, Carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
acid sphingomyelinase	1	0	0	1
HLA class I histocompatibility antigen, A alpha chain	0	0	1	1
Chain A, X-ray structure of the sucrose-phosphatase (SPP) from Synechocystis sp.PCC6803 in complex with trehalose	0	1	0	1
Chain A, X-ray structure of the sucrose-phosphatase (SPP) from Synechocystis sp.PCC6803 in complex with cellobiose	0	1	0	1
Chain A, X-ray structure of the sucrose-phosphatase (SPP) from Synechocystis sp.PCC6803 in complex with maltose	0	1	0	1
Trehalose-phosphatase	0	1	0	1
Trypanothione reductase	0	2	0	2
Cocaine esterase	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
UDP-glucuronosyltransferase 1-6	0	0	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member B7	0	1	0	1
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
Type-1 angiotensin II receptor	0	1	0	1
Platelet glycoprotein VI	0	0	1	1
Leukotriene B4 receptor 2	0	0	1	1
Transcription intermediary factor 1-alpha	0	1	0	1
Pancreatic triacylglycerol lipase	0	1	0	1
Succinate-semialdehyde dehydrogenase, mitochondrial	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Secreted chorismate mutase	0	1	0	1
E3 ubiquitin-protein ligase TRIM33	0	1	0	1
Sphingosine-1-phosphate lyase 1	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(1)

Research Excerpts

Overview

Context

Treatment

Research

Studies (368)

Protein Targets (1,061)

Sleep Apnea, Central

Synonyms(1)

Research Excerpts

Overview

Context

Treatment

Research

Studies (368)

Drugs Studied (142)

Protein Targets (1,061)