ketamine has been researched along with Hypertension in 63 studies
Ketamine: A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.
ketamine : A member of the class of cyclohexanones in which one of the hydrogens at position 2 is substituted by a 2-chlorophenyl group, while the other is substituted by a methylamino group.
Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
Excerpt | Relevance | Reference |
---|---|---|
"To compare the effect of an intravenous infusion of ketamine versus placebo on tourniquet induced hypertension in patients undergoing upper and lower limb surgery under general anaesthesia." | 9.24 | A randomized controlled trial to assess the effect of a ketamine infusion on tourniquet hypertension during general anaesthesia in patients undergoing upper and lower limb surgery. ( Kabugi, J; Mung'ayi, V; Ongaya, J; Sharif, T, 2017) |
"Ketamine is considered a stable induction agent for rapid sequence induction; however, hypotension rates up to 24% are reported." | 7.83 | Hemodynamic Response After Rapid Sequence Induction With Ketamine in Out-of-Hospital Patients at Risk of Shock as Defined by the Shock Index. ( Burns, B; Habig, K; Heldreich, C; Kruit, N; Miller, M; Reid, C; Ware, S, 2016) |
"Effects of Ca ion channel blockers, nicardipine, diltiazem and nifedipine on intraoperative hypertension were evaluated clinically in ninety surgical patients who received various surgical procedures under total intravenous anesthesia with droperidol, fentanyl and ketamine." | 7.68 | [Clinical study of total intravenous anesthesia with droperidol, fentanyl and ketamine--effects of nicardipine, diltiazem and nifedipine on intraoperative hypertension]. ( Hashimoto, Y; Hirota, K; Ishihara, H; Koh, H; Matsuki, A; Takagi, H, 1993) |
" A case of hypertension and pulmonary oedema in such a patient, possibly triggered by ketamine, is reported." | 7.68 | Hypertension and pulmonary oedema associated with ketamine administration in a patient with a history of substance abuse. ( Murphy, JL, 1993) |
"Intraoperative hypertension over 160 mmHg systolic and sinus tachycardia over 100 bpm are often observed during total intravenous anesthesia with droperidol, fentanyl and ketamine." | 7.68 | [Clinical study on total intravenous anesthesia with droperidol, fentanyl and ketamine--9. Control of intraoperative hypertension with diltiazem]. ( Ishihara, H; Kimura, F; Koh, H; Kushikata, T; Matsuki, A; Satoh, T, 1991) |
"Intraoperative hypertension over 160 mmHg systolic observed during total intravenous anesthesia with droperidol, fentanyl and ketamine was treated with intravenous nicardipine in 50 surgical patients." | 7.68 | [Clinical study on total intravenous anesthesia with droperidol, fentanyl and ketamine--4. Control of intraoperative hypertension with nicardipine]. ( Amano, N; Hirota, K; Ishihara, H; Koh, H; Kotani, N; Matsuki, A, 1991) |
"Ketamine appears to be a safe anesthetic option for children with PAH." | 5.36 | Perioperative complications in children with pulmonary hypertension undergoing general anesthesia with ketamine. ( Bair, E; Bratton, SL; Feinstein, JA; Hammer, GB; Kamra, K; Kuan, CC; Maan, H; Ramamoorthy, C; Williams, GD, 2010) |
"To compare the overall occurrence of hypertension and tachycardia immediately pre-intubation (post-induction) until 10 minutes post intubation between the study group receiving fentanyl at 1." | 5.30 | Effect of low-dose ketamine versus fentanyl on attenuating the haemodynamic response to laryngoscopy and endotracheal intubation in patients undergoing general anaesthesia: a prospective, double-blinded, randomised controlled trial. ( Bal, R; Mung'ayi, V; Ongewe, A, 2019) |
"To compare the effect of an intravenous infusion of ketamine versus placebo on tourniquet induced hypertension in patients undergoing upper and lower limb surgery under general anaesthesia." | 5.24 | A randomized controlled trial to assess the effect of a ketamine infusion on tourniquet hypertension during general anaesthesia in patients undergoing upper and lower limb surgery. ( Kabugi, J; Mung'ayi, V; Ongaya, J; Sharif, T, 2017) |
" Ketamine:norketamine ratios were strongly positively correlated with change in dissociation ratings (r = 0." | 5.12 | Influence of formulation and route of administration on ketamine's safety and tolerability: systematic review. ( Glue, P; Medlicott, NJ; Russell, B, 2021) |
"Ketamine, adverse effects, tachycardia, hypertension, postoperative pain, chronic postsurgical pain." | 4.31 | Effect of Analgesic Low-Dose Ketamine Infusions on the Cardiovascular Response: A Retrospective Analysis. ( Cadavid, AM; Calle, E; Camelo, JE; Casas, FD; Ramirez, CD; Tovar, A; Visbal, K, 2023) |
"Ketamine is considered a stable induction agent for rapid sequence induction; however, hypotension rates up to 24% are reported." | 3.83 | Hemodynamic Response After Rapid Sequence Induction With Ketamine in Out-of-Hospital Patients at Risk of Shock as Defined by the Shock Index. ( Burns, B; Habig, K; Heldreich, C; Kruit, N; Miller, M; Reid, C; Ware, S, 2016) |
" After administration of an intravenous dose of ketamine for fracture reduction, he developed severe hypertension." | 3.78 | Unexpected diagnosis of severe coarctation of the aorta after ketamine procedural sedation. ( Jiménez-Garcia, R; Perez-Garcia, MJ; Siles-Sanchez-Manjavacas, A, 2012) |
" Combinations using an alpha2-adrenoceptor agonist and ketamine have been shown to be effective for immobilization but are not reversible and can produce severe hypertension and prolonged or rough recoveries." | 3.71 | Cardiorespiratory effects of medetomidine-butorphanol, medetomidine-butorphanol-diazepam, and medetomidine-butorphanol-ketamine in captive red wolves (Canis rufus). ( Horne, WA; Kelly, BT; Larsen, RS; Loomis, MR; Sladky, KK; Stoskopf, MK, 2002) |
"Effects of Ca ion channel blockers, nicardipine, diltiazem and nifedipine on intraoperative hypertension were evaluated clinically in ninety surgical patients who received various surgical procedures under total intravenous anesthesia with droperidol, fentanyl and ketamine." | 3.68 | [Clinical study of total intravenous anesthesia with droperidol, fentanyl and ketamine--effects of nicardipine, diltiazem and nifedipine on intraoperative hypertension]. ( Hashimoto, Y; Hirota, K; Ishihara, H; Koh, H; Matsuki, A; Takagi, H, 1993) |
" A case of hypertension and pulmonary oedema in such a patient, possibly triggered by ketamine, is reported." | 3.68 | Hypertension and pulmonary oedema associated with ketamine administration in a patient with a history of substance abuse. ( Murphy, JL, 1993) |
"Intraoperative hypertension over 160 mmHg systolic and sinus tachycardia over 100 bpm are often observed during total intravenous anesthesia with droperidol, fentanyl and ketamine." | 3.68 | [Clinical study on total intravenous anesthesia with droperidol, fentanyl and ketamine--9. Control of intraoperative hypertension with diltiazem]. ( Ishihara, H; Kimura, F; Koh, H; Kushikata, T; Matsuki, A; Satoh, T, 1991) |
"Intraoperative hypertension over 160 mmHg systolic observed during total intravenous anesthesia with droperidol, fentanyl and ketamine was treated with intravenous nicardipine in 50 surgical patients." | 3.68 | [Clinical study on total intravenous anesthesia with droperidol, fentanyl and ketamine--4. Control of intraoperative hypertension with nicardipine]. ( Amano, N; Hirota, K; Ishihara, H; Koh, H; Kotani, N; Matsuki, A, 1991) |
"9% saline (placebo) in combination with ketamine and rocuronium, according to a weight-based dosing schedule." | 3.11 | Fentanyl versus placebo with ketamine and rocuronium for patients undergoing rapid sequence intubation in the emergency department: The FAKT study-A randomized clinical trial. ( Aneman, A; Burns, B; Buttfield, A; Ferguson, I; Harris, IA; Milligan, J; Reid, C; Shepherd, S, 2022) |
"We observed that respiratory depression (19." | 2.82 | Propofol-ketamine combination: a choice with less complications and better hemodynamic stability compared to propofol? On a prospective study in a group of colonoscopy patients. ( Babayıgıt, M; Baykal Tutal, Z; Derelı, N; Gulec, H; Horasanlı, E; Inceoz, H; Kurtay, A, 2016) |
"To evaluate the anesthetic and cardiopulmonary effects of ketamine-dexmedetomidine combined with local anesthesia, associated or not in the postoperative period with different doses of atipamezole, for orchiectomy in cats." | 1.72 | Ketamine-dexmedetomidine combined with local anesthesia, with or without different doses of atipamezole in the postoperative period, for orchiectomy in cats. ( Cappelli, N; da Silva, MFA; de Carvalho, WTS; Gomes, VH; Mignani, BTG; Pimentel, VC, 2022) |
"esketamine injections were mild and well tolerated for doses up to 1 mg/kg." | 1.56 | Effects of subcutaneous esketamine on blood pressure and heart rate in treatment-resistant depression. ( Abdo, G; Barbosa, M; Cohrs, FM; de Jesus Mari, J; Del Porto, JA; Del Sant, LC; Delfino, R; Fava, VAR; Lacerda, ALT; Liberatori, A; Lucchese, AC; Magalhães, EJM; Nakahira, C; Sarin, LM; Steiglich, MS; Surjan, J; Tuena, MA, 2020) |
"Ketamine appears to be a safe anesthetic option for children with PAH." | 1.36 | Perioperative complications in children with pulmonary hypertension undergoing general anesthesia with ketamine. ( Bair, E; Bratton, SL; Feinstein, JA; Hammer, GB; Kamra, K; Kuan, CC; Maan, H; Ramamoorthy, C; Williams, GD, 2010) |
"Hypertension was present in all groups during anaesthesia with mean (+/- SD) systolic pressure of 30." | 1.33 | Cardiopulmonary effects of medetomidine or midazolam in combination with ketamine or tiletamine/zolazepam for the immobilisation of captive cheetahs (Acinonyx jubatus). ( Jago, M; Stegmann, GF, 2006) |
"Hypertension was recorded in 11." | 1.28 | A retrospective survey of anaesthesia in horses with colic. ( Adams, JG; Cowgill, LM; Trim, CM; Ward, SL, 1989) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 26 (41.27) | 18.7374 |
1990's | 10 (15.87) | 18.2507 |
2000's | 6 (9.52) | 29.6817 |
2010's | 14 (22.22) | 24.3611 |
2020's | 7 (11.11) | 2.80 |
Authors | Studies |
---|---|
Huang, TL | 1 |
Mayence, A | 1 |
Vanden Eynde, JJ | 1 |
Ferguson, I | 1 |
Buttfield, A | 1 |
Burns, B | 2 |
Reid, C | 2 |
Shepherd, S | 1 |
Milligan, J | 1 |
Harris, IA | 1 |
Aneman, A | 1 |
Gomes, VH | 3 |
de Carvalho, WTS | 3 |
Pimentel, VC | 3 |
Cappelli, N | 3 |
Mignani, BTG | 3 |
da Silva, MFA | 3 |
Cadavid, AM | 1 |
Casas, FD | 1 |
Camelo, JE | 1 |
Tovar, A | 1 |
Ramirez, CD | 1 |
Calle, E | 1 |
Visbal, K | 1 |
Ongewe, A | 1 |
Mung'ayi, V | 2 |
Bal, R | 1 |
Del Sant, LC | 1 |
Sarin, LM | 1 |
Magalhães, EJM | 1 |
Lucchese, AC | 1 |
Tuena, MA | 1 |
Nakahira, C | 1 |
Fava, VAR | 1 |
Delfino, R | 1 |
Surjan, J | 1 |
Steiglich, MS | 1 |
Barbosa, M | 1 |
Abdo, G | 1 |
Cohrs, FM | 1 |
Liberatori, A | 1 |
Del Porto, JA | 1 |
Lacerda, ALT | 1 |
de Jesus Mari, J | 1 |
Glue, P | 1 |
Russell, B | 1 |
Medlicott, NJ | 1 |
McIntyre, RS | 1 |
Rosenblat, JD | 1 |
Nemeroff, CB | 1 |
Sanacora, G | 1 |
Murrough, JW | 1 |
Berk, M | 1 |
Brietzke, E | 1 |
Dodd, S | 1 |
Gorwood, P | 1 |
Ho, R | 1 |
Iosifescu, DV | 1 |
Lopez Jaramillo, C | 1 |
Kasper, S | 1 |
Kratiuk, K | 1 |
Lee, JG | 1 |
Lee, Y | 1 |
Lui, LMW | 1 |
Mansur, RB | 1 |
Papakostas, GI | 1 |
Subramaniapillai, M | 1 |
Thase, M | 1 |
Vieta, E | 1 |
Young, AH | 1 |
Zarate, CA | 1 |
Stahl, S | 1 |
Raisis, AL | 1 |
Mosing, M | 1 |
Hosgood, GL | 1 |
Secombe, CJ | 1 |
Adler, A | 1 |
Waldmann, AD | 1 |
Ongaya, J | 1 |
Sharif, T | 1 |
Kabugi, J | 1 |
Shah, P | 1 |
McDowell, M | 1 |
Ebisu, R | 1 |
Hanif, T | 1 |
Toerne, T | 1 |
Tang, MHY | 1 |
Chong, YK | 1 |
Chan, CY | 1 |
Ching, CK | 1 |
Lai, CK | 1 |
Li, YK | 1 |
Mak, TWL | 1 |
Stemmet, GP | 1 |
Meyer, LC | 1 |
Bruns, A | 1 |
Buss, P | 1 |
Zimmerman, D | 1 |
Koeppel, K | 1 |
Zeiler, GE | 1 |
Bencze, M | 1 |
Behuliak, M | 1 |
Zicha, J | 1 |
van Hecke, O | 1 |
Guthrie, B | 1 |
Baykal Tutal, Z | 1 |
Gulec, H | 1 |
Derelı, N | 1 |
Babayıgıt, M | 1 |
Kurtay, A | 1 |
Inceoz, H | 1 |
Horasanlı, E | 1 |
Miller, M | 1 |
Kruit, N | 1 |
Heldreich, C | 1 |
Ware, S | 1 |
Habig, K | 1 |
Burmon, C | 1 |
Adamakos, F | 1 |
Filardo, M | 1 |
Motov, S | 1 |
Williams, GD | 1 |
Maan, H | 1 |
Ramamoorthy, C | 1 |
Kamra, K | 1 |
Bratton, SL | 1 |
Bair, E | 1 |
Kuan, CC | 1 |
Hammer, GB | 1 |
Feinstein, JA | 1 |
Hofer, KE | 1 |
Grager, B | 1 |
Müller, DM | 1 |
Rauber-Lüthy, C | 1 |
Kupferschmidt, H | 1 |
Rentsch, KM | 1 |
Ceschi, A | 1 |
Perez-Garcia, MJ | 1 |
Jiménez-Garcia, R | 1 |
Siles-Sanchez-Manjavacas, A | 1 |
Larsen, RS | 1 |
Loomis, MR | 1 |
Kelly, BT | 1 |
Sladky, KK | 1 |
Stoskopf, MK | 1 |
Horne, WA | 1 |
Neema, PK | 1 |
Unnikrishnan, M | 1 |
Sinha, PK | 1 |
Rathod, RC | 1 |
Brookes, ZL | 1 |
Reilly, CS | 1 |
Brown, NJ | 1 |
Stegmann, GF | 1 |
Jago, M | 1 |
Broughton Pipkin, F | 1 |
Waldron, BA | 1 |
Altura, BM | 1 |
Altura, BT | 1 |
Baer, G | 1 |
Rorarius, M | 1 |
Schavikin, L | 1 |
Väyrynen, T | 1 |
Kudo, T | 1 |
Kudo, M | 1 |
Hashimoto, H | 1 |
Koh, H | 4 |
Ishihara, H | 4 |
Matsuki, A | 4 |
Tanaka, M | 1 |
Nishikawa, T | 1 |
Nitschke, T | 1 |
Munro, HM | 1 |
Sleigh, JW | 1 |
Paxton, LD | 1 |
Hashimoto, Y | 1 |
Takagi, H | 1 |
Hirota, K | 2 |
Murphy, JL | 1 |
Trim, CM | 1 |
Adams, JG | 1 |
Cowgill, LM | 1 |
Ward, SL | 1 |
van Gorp, AW | 1 |
Schenau, DS | 1 |
Hoeks, AP | 1 |
Boudier, HA | 1 |
de Mey, JG | 1 |
Reneman, RS | 1 |
Satsumae, T | 1 |
Yamaguchi, H | 1 |
Sakaguchi, M | 1 |
Yasunaga, T | 1 |
Yamashita, S | 1 |
Yamamoto, S | 1 |
Kida, H | 1 |
Dauri, A | 1 |
Colace, F | 1 |
Bellanca, T | 1 |
Bertolini, G | 1 |
Mendenhall, MK | 1 |
Ahlgren, EW | 1 |
Reves, JG | 1 |
Lell, WA | 1 |
McCracken, LE | 1 |
Kravetz, RA | 1 |
Prough, DS | 1 |
Juan Vicente, A | 1 |
Pedraz de Cabo, J | 1 |
Elliott, E | 1 |
Hanid, TK | 1 |
Arthur, LJ | 1 |
Kay, B | 1 |
Reyes Toso, CF | 1 |
Linares, LM | 1 |
Rodríguez, RR | 1 |
Kimura, F | 1 |
Kushikata, T | 1 |
Satoh, T | 1 |
Amano, N | 1 |
Kotani, N | 1 |
Gregoriades, SA | 1 |
Shah, K | 1 |
Karlman, R | 1 |
Heller, J | 1 |
Evans, J | 1 |
Rosen, M | 1 |
Weeks, RD | 1 |
Wise, C | 1 |
Wilson, RD | 1 |
Ashy, TM | 1 |
Allen, CR | 1 |
Priano, LL | 1 |
Dundee, JW | 3 |
Bovill, J | 1 |
Szappanyos, G | 1 |
Gemperle, M | 1 |
Rifat, K | 1 |
Constantin, B | 1 |
Condat, P | 1 |
Jourde, M | 1 |
Condat, M | 1 |
Lapalus, P | 1 |
Little, B | 1 |
Chang, T | 1 |
Chucot, L | 1 |
Dill, WA | 1 |
Enrile, LL | 1 |
Glazko, AJ | 1 |
Jassani, M | 1 |
Kretchmer, H | 1 |
Sweet, AY | 1 |
Hunter, AR | 1 |
Langrehr, D | 1 |
Neuhaus, R | 1 |
Tamiya, K | 1 |
Yamazaki, T | 1 |
Kawabata, Y | 1 |
Yasukawa, K | 1 |
Nanba, M | 1 |
Leon, AS | 1 |
Thomas, PE | 1 |
Sernatinger, E | 1 |
Canlas, A | 1 |
Bovill, JG | 2 |
Clarke, RS | 2 |
Pandit, SK | 2 |
Moore, J | 1 |
Dalsgård, M | 1 |
Thorshauge, C | 1 |
Brockmüller, KD | 1 |
Kaplan, JA | 1 |
Cooperman, LH | 1 |
Ginsberg, H | 1 |
Gerber, JA | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Effect of Intravenous Low-dose Esketamine on Maternal Depression at 2 Years After Childbirth in Women With Prenatal Depression: 2-year Follow-up of a Randomized Controlled Trial[NCT05698394] | Phase 4 | 364 participants (Actual) | Interventional | 2020-06-19 | Active, not recruiting | ||
Phenomenological Explorations of the Esketamine-Induced Transient Dissociative State[NCT06133309] | 15 participants (Anticipated) | Interventional | 2023-12-01 | Not yet recruiting | |||
Prospective Study of Induction Medications Used in the Rapid Sequence Intubation of Trauma Patients and a Comparison of Effects on Outcomes[NCT04291521] | 7,000 participants (Anticipated) | Observational | 2024-01-01 | Not yet recruiting | |||
The Pharmacokinetics of Ketamine in the Breast Milk of Lactating Women: Quantification of Ketamine and Metabolites[NCT04285684] | Early Phase 1 | 4 participants (Actual) | Interventional | 2019-12-20 | Completed | ||
Conscious Dying/Conscious Living: Ketamine-Assisted Psychotherapy (KAP) for Patients at End of Life-A Pilot Study for Palliative and Hospice Care[NCT05214417] | Phase 2 | 120 participants (Anticipated) | Interventional | 2022-05-01 | Not yet recruiting | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
"Quantitative analysis of the concentration of ketamine and its metabolites in breast milk (collected by pumping breast milk into containers at 24 and 30 hours post ketamine IM administration) was performed at the Clinical Medicine and Toxicology Laboratory at UCSF School of Medicine. Sample aliquots were frozen in our conventional freezer at the clinic where the sessions took place, labelled with a HIPAA compliant code which blinded the lab to all patient data.~The limits of sensitivity for the quantification of each substance were:~Ketamine: 0.25 ng Norketamine: 0.25 ng Dehydronorketamine: 0.1 ng Hydroxynorketamine: 0.25 ng" (NCT04285684)
Timeframe: 24 and 30 hour collections
Intervention | ng/mL (Mean) | |
---|---|---|
24 Hours | 30 Hours | |
Ketamine During Lactation | .3 | .3 |
"Quantitative analysis of the concentration of ketamine and its metabolites in breast milk (collected by pumping breast milk into containers at 3, 6, 9, and 12 hours post ketamine IM administration) was performed at the Clinical Medicine and Toxicology Laboratory at UCSF School of Medicine. Sample aliquots were frozen in our conventional freezer at the clinic where the sessions took place, labelled with a HIPAA compliant code which blinded the lab to all patient data.~The limits of sensitivity for the quantification of each substance were:~Ketamine: 0.25 ng Norketamine: 0.25 ng Dehydronorketamine: 0.1 ng Hydroxynorketamine: 0.25 ng" (NCT04285684)
Timeframe: 3, 6, 9, and 12 hour collections
Intervention | ng/mL (Mean) | |||
---|---|---|---|---|
3 Hours | 6 Hours | 9 Hours | 12 Hours | |
Ketamine During Lactation | .56 | .55 | .45 | .21 |
"Quantitative analysis of the concentration of ketamine and its metabolites in breast milk (collected by pumping breast milk into containers at 3, 6, 9, and 12 hours post ketamine IM administration) was performed at the Clinical Medicine and Toxicology Laboratory at UCSF School of Medicine. Sample aliquots were frozen in our conventional freezer at the clinic where the sessions took place, labelled with a HIPAA compliant code which blinded the lab to all patient data.~The limits of sensitivity for the quantification of each substance were:~Ketamine: 0.25 ng Norketamine: 0.25 ng Dehydronorketamine: 0.1 ng Hydroxynorketamine: 0.25 ng" (NCT04285684)
Timeframe: 3, 6, 9, and 12 hour collections
Intervention | ng/mL (Mean) | |||
---|---|---|---|---|
3 Hours | 6 Hours | 9 Hours | 12 Hours | |
Ketamine During Lactation | 2.0 | 1.9 | 1.4 | 1.1 |
"Quantitative analysis of the concentration of ketamine and its metabolites in breast milk (collected by pumping breast milk into containers at 24 and 30 hours post ketamine IM administration) was performed at the Clinical Medicine and Toxicology Laboratory at UCSF School of Medicine. Sample aliquots were frozen in our conventional freezer at the clinic where the sessions took place, labelled with a HIPAA compliant code which blinded the lab to all patient data.~The limits of sensitivity for the quantification of each substance were:~Ketamine: 0.25 ng Norketamine: 0.25 ng Dehydronorketamine: 0.1 ng Hydroxynorketamine: 0.25 ng" (NCT04285684)
Timeframe: 24 and 30 hour collections
Intervention | ng/mL (Mean) | |
---|---|---|
24 Hours | 30 Hours | |
Ketamine During Lactation | 30.5 | 13.9 |
"Quantitative analysis of the concentration of ketamine and its metabolites in breast milk (collected by pumping breast milk into containers at 3, 6, 9, and 12 hours post ketamine IM administration) was performed at the Clinical Medicine and Toxicology Laboratory at UCSF School of Medicine. Sample aliquots were frozen in our conventional freezer at the clinic where the sessions took place, labelled with a HIPAA compliant code which blinded the lab to all patient data.~The limits of sensitivity for the quantification of each substance were:~Ketamine: 0.25 ng Norketamine: 0.25 ng Dehydronorketamine: 0.1 ng Hydroxynorketamine: 0.25 ng" (NCT04285684)
Timeframe: 3, 6, 9, and 12 hour collections
Intervention | ng/mL (Mean) | |||
---|---|---|---|---|
3 Hours | 6 Hours | 9 Hours | 12 Hours | |
Ketamine During Lactation | 29.9 | 28.3 | 25.6 | 17.5 |
"Quantitative analysis of the concentration of ketamine and its metabolites in breast milk (collected by pumping breast milk into containers at 3, 6, 9, and 12 hours post ketamine IM administration) was performed at the Clinical Medicine and Toxicology Laboratory at UCSF School of Medicine. Sample aliquots were frozen in our conventional freezer at the clinic where the sessions took place, labelled with a HIPAA compliant code which blinded the lab to all patient data.~The limits of sensitivity for the quantification of each substance were:~Ketamine: 0.25 ng Norketamine: 0.25 ng Dehydronorketamine: 0.1 ng Hydroxynorketamine: 0.25 ng" (NCT04285684)
Timeframe: 3, 6, 9, and 12 hour collections
Intervention | ng/mL (Mean) | |||
---|---|---|---|---|
3 Hours | 6 Hours | 9 Hours | 12 Hours | |
Ketamine During Lactation | 64.1 | 66.9 | 54.6 | 41.6 |
"Quantitative analysis of the concentration of ketamine and its metabolites in breast milk (collected by pumping breast milk into containers at 24 and 30 hours post ketamine IM administration) was performed at the Clinical Medicine and Toxicology Laboratory at UCSF School of Medicine. Sample aliquots were frozen in our conventional freezer at the clinic where the sessions took place, labelled with a HIPAA compliant code which blinded the lab to all patient data.~The limits of sensitivity for the quantification of each substance were:~Ketamine: 0.25 ng Norketamine: 0.25 ng Dehydronorketamine: 0.1 ng Hydroxynorketamine: 0.25 ng" (NCT04285684)
Timeframe: 24 and 30 hour collections
Intervention | ng/mL (Mean) | |
---|---|---|
24 Hours | 30 Hours | |
Ketamine During Lactation | 4.9 | 6.4 |
"Quantitative analysis of the concentration of ketamine and its metabolites in breast milk (collected by pumping breast milk into containers at 3, 6, 9, and 12 hours post ketamine IM administration) was performed at the Clinical Medicine and Toxicology Laboratory at UCSF School of Medicine. Sample aliquots were frozen in our conventional freezer at the clinic where the sessions took place, labelled with a HIPAA compliant code which blinded the lab to all patient data.~The limits of sensitivity for the quantification of each substance were:~Ketamine: 0.25 ng Norketamine: 0.25 ng Dehydronorketamine: 0.1 ng Hydroxynorketamine: 0.25 ng" (NCT04285684)
Timeframe: 3, 6, 9, and 12 hour collections
Intervention | ng/mL (Mean) | |||
---|---|---|---|---|
3 Hours | 6 Hours | 9 Hours | 12 Hours | |
Ketamine During Lactation | 51.2 | 22.6 | 10.6 | 4.5 |
"Quantitative analysis of the concentration of ketamine and its metabolites in breast milk (collected by pumping breast milk into containers at 3, 6, 9, and 12 hours post ketamine IM administration) was performed at the Clinical Medicine and Toxicology Laboratory at UCSF School of Medicine. Sample aliquots were frozen in our conventional freezer at the clinic where the sessions took place, labelled with a HIPAA compliant code which blinded the lab to all patient data.~The limits of sensitivity for the quantification of each substance were:~Ketamine: 0.25 ng Norketamine: 0.25 ng Dehydronorketamine: 0.1 ng Hydroxynorketamine: 0.25 ng" (NCT04285684)
Timeframe: 3, 6, 9, and 12 hour collections
Intervention | ng/mL (Mean) | |||
---|---|---|---|---|
3 Hours | 6 Hours | 9 Hours | 12 Hours | |
Ketamine During Lactation | 125.0 | 48.2 | 21.6 | 18.5 |
"Quantitative analysis of the concentration of ketamine and its metabolites in breast milk (collected by pumping breast milk into containers at 24 and 30 hours post ketamine IM administration) was performed at the Clinical Medicine and Toxicology Laboratory at UCSF School of Medicine. Sample aliquots were frozen in our conventional freezer at the clinic where the sessions took place, labelled with a HIPAA compliant code which blinded the lab to all patient data.~The limits of sensitivity for the quantification of each substance were:~Ketamine: 0.25 ng Norketamine: 0.25 ng Dehydronorketamine: 0.1 ng Hydroxynorketamine: 0.25 ng" (NCT04285684)
Timeframe: 24 and 30 hour collections
Intervention | ng/mL (Mean) | |
---|---|---|
24 Hours | 30 Hours | |
Ketamine During Lactation | 10.3 | 9.9 |
"Quantitative analysis of the concentration of ketamine and its metabolites in breast milk (collected by pumping breast milk into containers at 3, 6, 9, and 12 hours post ketamine IM administration) was performed at the Clinical Medicine and Toxicology Laboratory at UCSF School of Medicine. Sample aliquots were frozen in our conventional freezer at the clinic where the sessions took place, labelled with a HIPAA compliant code which blinded the lab to all patient data.~The limits of sensitivity for the quantification of each substance were:~Ketamine: 0.25 ng Norketamine: 0.25 ng Dehydronorketamine: 0.1 ng Hydroxynorketamine: 0.25 ng" (NCT04285684)
Timeframe: 3, 6, 9, and 12 hour collections
Intervention | ng/mL (Mean) | |||
---|---|---|---|---|
3 Hours | 6 Hours | 9 Hours | 12 Hours | |
Ketamine During Lactation | 42.6 | 28.6 | 18.8 | 8.7 |
"Quantitative analysis of the concentration of ketamine and its metabolites in breast milk (collected by pumping breast milk into containers at 3, 6, 9, and 12 hours post ketamine IM administration) was performed at the Clinical Medicine and Toxicology Laboratory at UCSF School of Medicine. Sample aliquots were frozen in our conventional freezer at the clinic where the sessions took place, labelled with a HIPAA compliant code which blinded the lab to all patient data.~The limits of sensitivity for the quantification of each substance were:~Ketamine: 0.25 ng Norketamine: 0.25 ng Dehydronorketamine: 0.1 ng Hydroxynorketamine: 0.25 ng" (NCT04285684)
Timeframe: 3, 6, 9, and 12 hour collections
Intervention | ng/mL (Mean) | |||
---|---|---|---|---|
3 Hours | 6 Hours | 9 Hours | 12 Hours | |
Ketamine During Lactation | 92.7 | 62.4 | 37.3 | 32.3 |
5 reviews available for ketamine and Hypertension
Article | Year |
---|---|
Some non-conventional biomolecular targets for diamidines. A short survey.
Topics: Amidines; Animals; Diabetes Mellitus, Type 2; DNA; Enzymes; Humans; Hypertension; Ion Channels; Myot | 2014 |
Influence of formulation and route of administration on ketamine's safety and tolerability: systematic review.
Topics: Antidepressive Agents; Dissociative Disorders; Drug Administration Routes; Drug Delivery Systems; Hu | 2021 |
Synthesizing the Evidence for Ketamine and Esketamine in Treatment-Resistant Depression: An International Expert Opinion on the Available Evidence and Implementation.
Topics: Antidepressive Agents; Delivery of Health Care; Depressive Disorder, Major; Depressive Disorder, Tre | 2021 |
Synthesizing the Evidence for Ketamine and Esketamine in Treatment-Resistant Depression: An International Expert Opinion on the Available Evidence and Implementation.
Topics: Antidepressive Agents; Delivery of Health Care; Depressive Disorder, Major; Depressive Disorder, Tre | 2021 |
Synthesizing the Evidence for Ketamine and Esketamine in Treatment-Resistant Depression: An International Expert Opinion on the Available Evidence and Implementation.
Topics: Antidepressive Agents; Delivery of Health Care; Depressive Disorder, Major; Depressive Disorder, Tre | 2021 |
Synthesizing the Evidence for Ketamine and Esketamine in Treatment-Resistant Depression: An International Expert Opinion on the Available Evidence and Implementation.
Topics: Antidepressive Agents; Delivery of Health Care; Depressive Disorder, Major; Depressive Disorder, Tre | 2021 |
Microcirculatory actions and uses of naturally-occurring (magnesium) and novel synthetic calcium channel blockers.
Topics: Anesthesia; Animals; Arterioles; Blood Pressure; Calcium; Calcium Channel Blockers; Cell Membrane Pe | 1984 |
Drugs for producing dissociative states.
Topics: Anesthesia, Dental; Anesthetics; Anesthetics, Dissociative; Brain Diseases; Cardiac Catheterization; | 1973 |
11 trials available for ketamine and Hypertension
Article | Year |
---|---|
Fentanyl versus placebo with ketamine and rocuronium for patients undergoing rapid sequence intubation in the emergency department: The FAKT study-A randomized clinical trial.
Topics: Australia; Emergency Service, Hospital; Fentanyl; Humans; Hypertension; Hypotension; Intubation, Int | 2022 |
Effect of low-dose ketamine versus fentanyl on attenuating the haemodynamic response to laryngoscopy and endotracheal intubation in patients undergoing general anaesthesia: a prospective, double-blinded, randomised controlled trial.
Topics: Adolescent; Adult; Age Factors; Aged; Anesthetics; Double-Blind Method; Elective Surgical Procedures | 2019 |
A randomized controlled trial to assess the effect of a ketamine infusion on tourniquet hypertension during general anaesthesia in patients undergoing upper and lower limb surgery.
Topics: Adult; Analgesics; Anesthesia, General; Blood Pressure; Double-Blind Method; Female; Heart Rate; Hem | 2017 |
Compared to etorphine-azaperone, the ketamine-butorphanol-medetomidine combination is also effective at immobilizing zebra (Equus zebra).
Topics: Analgesics, Opioid; Anesthetics, Dissociative; Animals; Animals, Wild; Azaperone; Blood Pressure; Bu | 2019 |
Propofol-ketamine combination: a choice with less complications and better hemodynamic stability compared to propofol? On a prospective study in a group of colonoscopy patients.
Topics: Anesthetics, Combined; Colonoscopy; Double-Blind Method; Female; Heart Rate; Humans; Hypertension; H | 2016 |
[Endocrine effects of nicardipine on intraoperative hypertension under droperidol-fentanyl-ketamine (DFK) anesthesia].
Topics: Adult; Aged; Aldosterone; Anesthesia, Intravenous; Atrial Natriuretic Factor; Catecholamines; Droper | 1995 |
Oral clonidine premedication attenuates the hypertensive response to ketamine.
Topics: Administration, Oral; Adolescent; Adult; Anesthesia, Intravenous; Blood Pressure; Clonidine; Female; | 1994 |
The cardiovascular response to ketamine: the effects of clonidine and lignocaine.
Topics: Adult; Aged; Clonidine; Double-Blind Method; Female; Humans; Hypertension; Ketamine; Lidocaine; Male | 1993 |
Preoperative small-dose ketamine prevented tourniquet-induced arterial pressure increase in orthopedic patients under general anesthesia.
Topics: Adolescent; Adult; Aged; Analgesics; Anesthesia, General; Blood Pressure; Double-Blind Method; Femal | 2001 |
Comparison of morphine and ketamine anesthetic technics for coronary surgery: a randomized study.
Topics: Adult; Aged; Anesthetics; Arrhythmias, Cardiac; Diazepam; Hemodynamics; Humans; Hypertension; Ketami | 1978 |
Ketamine.
Topics: Analgesics; Anesthetics; Atropine; Clinical Trials as Topic; Cyclohexanes; Delirium; Humans; Hyperte | 1970 |
47 other studies available for ketamine and Hypertension
Article | Year |
---|---|
Ketamine-dexmedetomidine combined with local anesthesia, with or without different doses of atipamezole in the postoperative period, for orchiectomy in cats.
Topics: Anesthesia, Local; Anesthetics; Animals; Cat Diseases; Cats; Dexmedetomidine; Hypertension; Ketamine | 2022 |
Ketamine-dexmedetomidine combined with local anesthesia, with or without different doses of atipamezole in the postoperative period, for orchiectomy in cats.
Topics: Anesthesia, Local; Anesthetics; Animals; Cat Diseases; Cats; Dexmedetomidine; Hypertension; Ketamine | 2022 |
Ketamine-dexmedetomidine combined with local anesthesia, with or without different doses of atipamezole in the postoperative period, for orchiectomy in cats.
Topics: Anesthesia, Local; Anesthetics; Animals; Cat Diseases; Cats; Dexmedetomidine; Hypertension; Ketamine | 2022 |
Ketamine-dexmedetomidine combined with local anesthesia, with or without different doses of atipamezole in the postoperative period, for orchiectomy in cats.
Topics: Anesthesia, Local; Anesthetics; Animals; Cat Diseases; Cats; Dexmedetomidine; Hypertension; Ketamine | 2022 |
Effect of Analgesic Low-Dose Ketamine Infusions on the Cardiovascular Response: A Retrospective Analysis.
Topics: Acute Pain; Adult; Analgesics; Analgesics, Opioid; Humans; Hypertension; Ketamine; Pain, Postoperati | 2023 |
Effects of subcutaneous esketamine on blood pressure and heart rate in treatment-resistant depression.
Topics: Adult; Antidepressive Agents; Blood Pressure; Cohort Studies; Depressive Disorder, Treatment-Resista | 2020 |
The use of electrical impedance tomography (EIT) to evaluate pulse rate in anaesthetised horses.
Topics: Anesthesia; Anesthetics, Intravenous; Animals; Diazepam; Electric Impedance; Heart Rate; Horses; Hyp | 2021 |
Adjunctive Use of Ketamine for Benzodiazepine-Resistant Severe Alcohol Withdrawal: a Retrospective Evaluation.
Topics: Adult; Aged; Alcohol Withdrawal Seizures; Benzodiazepines; Blood Alcohol Content; Central Nervous Sy | 2018 |
Cluster of acute poisonings associated with an emerging ketamine analogue, 2-oxo-PCE.
Topics: Adult; Chromatography, Liquid; Confusion; Consciousness Disorders; Female; Forensic Toxicology; Gas | 2018 |
The impact of four different classes of anesthetics on the mechanisms of blood pressure regulation in normotensive and spontaneously hypertensive rats.
Topics: Anesthetics; Anesthetics, Combined; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressur | 2013 |
Oral ketamine analgesia in chronic pain and problematic rise in blood pressure.
Topics: Aged; Analgesics; Chronic Pain; Female; Humans; Hypertension; Ketamine; Low Back Pain | 2014 |
Hemodynamic Response After Rapid Sequence Induction With Ketamine in Out-of-Hospital Patients at Risk of Shock as Defined by the Shock Index.
Topics: Adult; Aged; Analgesics; Blood Pressure; Craniocerebral Trauma; Emergency Medical Services; Female; | 2016 |
Acute pulmonary edema associated with ketamine-induced hypertension during procedural sedation in the ED.
Topics: Acute Disease; Anesthetics, Dissociative; Anti-Bacterial Agents; Arthralgia; Arthrocentesis; Cardiop | 2017 |
Perioperative complications in children with pulmonary hypertension undergoing general anesthesia with ketamine.
Topics: Adolescent; Anesthesia, General; Anesthetics, Dissociative; Blood Pressure; Cardiac Surgical Procedu | 2010 |
Ketamine-like effects after recreational use of methoxetamine.
Topics: Anesthetics, Dissociative; Confusion; Cyclohexanones; Cyclohexylamines; Dyskinesias; Humans; Hyperte | 2012 |
Unexpected diagnosis of severe coarctation of the aorta after ketamine procedural sedation.
Topics: Anesthetics, Dissociative; Aortic Coarctation; Child; Forearm Injuries; Humans; Hypertension; Ketami | 2012 |
Cardiorespiratory effects of medetomidine-butorphanol, medetomidine-butorphanol-diazepam, and medetomidine-butorphanol-ketamine in captive red wolves (Canis rufus).
Topics: Adrenergic alpha-Antagonists; Anesthetics, Dissociative; Animals; Animals, Zoo; Blood Pressure; Body | 2002 |
Anesthetic management for a hypertensive patent ductus arteriosus (PDA) closure in a patient with surgically uncorrectable long-segment right pulmonary artery hypoplasia and a ventricular septal defect.
Topics: Analgesics; Anesthesia; Anesthetics, Inhalation; Anesthetics, Intravenous; Child, Preschool; Ductus | 2003 |
Differential effects of propofol, ketamine, and thiopental anaesthesia on the skeletal muscle microcirculation of normotensive and hypertensive rats in vivo.
Topics: Anesthetics, Dissociative; Anesthetics, Intravenous; Animals; Arterioles; Dose-Response Relationship | 2004 |
Cardiopulmonary effects of medetomidine or midazolam in combination with ketamine or tiletamine/zolazepam for the immobilisation of captive cheetahs (Acinonyx jubatus).
Topics: Acinonyx; Anesthetics, Combined; Animals; Blood Gas Analysis; Heart Rate; Hypertension; Immobilizati | 2006 |
Ketamine hypertension and the renin-angiotensin system.
Topics: Adult; Aldosterone; Angiotensin II; Blood Pressure; Female; Humans; Hypertension; Ketamine; Renin; R | 1983 |
[Recovery after ketamine-diazepam and thiopental-fentanyl-infusion anesthesia with jet-ventilation for laryngomicroscopy].
Topics: Adult; Aged; Anesthesia, Intravenous; Blood Pressure; Diazepam; Female; Fentanyl; Humans; Hypertensi | 1983 |
[Treatment of intraoperative status asthmaticus with ketamine].
Topics: Airway Resistance; Alfentanil; Anesthesia, General; Breast Neoplasms; Female; Humans; Hypertension; | 1994 |
[Clinical study of total intravenous anesthesia with droperidol, fentanyl and ketamine--effects of nicardipine, diltiazem and nifedipine on intraoperative hypertension].
Topics: Anesthesia, Intravenous; Calcium Channel Blockers; Diltiazem; Droperidol; Female; Fentanyl; Humans; | 1993 |
Hypertension and pulmonary oedema associated with ketamine administration in a patient with a history of substance abuse.
Topics: Adult; Anesthesia, Intravenous; Anesthesia, Spinal; Crack Cocaine; Female; Humans; Hypertension; Ket | 1993 |
A retrospective survey of anaesthesia in horses with colic.
Topics: Administration, Inhalation; Anesthesia; Anesthetics, Dissociative; Anesthetics, Inhalation; Anesthet | 1989 |
In spontaneously hypertensive rats alterations in aortic wall properties precede development of hypertension.
Topics: Adrenergic alpha-Agonists; Age Factors; Anesthetics, Dissociative; Animals; Aorta, Thoracic; Blood P | 2000 |
[Possibilities of controlling the cardiovascular side effects of ketamine. Experimental and clinical study].
Topics: Adult; Anesthesia, Intravenous; Animals; Blood Pressure; Central Venous Pressure; Female; Heart Rate | 1977 |
Anesthetic considerations in surgery for gastrointestinal disease.
Topics: Aged; Anesthetics; Drug Interactions; Enflurane; Female; Gastrointestinal Diseases; Halothane; Human | 1979 |
[Ionic changes produced by the use of ketamine].
Topics: Anesthesia, General; Child; Child, Preschool; Electrolytes; Female; Halothane; Humans; Hypertension; | 1978 |
Ketamine anaesthesia for medical procedures in children.
Topics: Adolescent; Anesthesia, Intravenous; Atropine; Child; Child, Preschool; Drug Combinations; Female; H | 1976 |
[Cardiovascular effects of ketamine anesthesia in rats treated with enalapril and propranolol].
Topics: Anesthesia, General; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Enalapril; H | 1992 |
[Clinical study on total intravenous anesthesia with droperidol, fentanyl and ketamine--9. Control of intraoperative hypertension with diltiazem].
Topics: Anesthesia, Intravenous; Diltiazem; Female; Fentanyl; Humans; Hypertension; Intraoperative Complicat | 1991 |
[Clinical study on total intravenous anesthesia with droperidol, fentanyl and ketamine--4. Control of intraoperative hypertension with nicardipine].
Topics: Adolescent; Adult; Aged; Anesthesia, Intravenous; Droperidol; Female; Fentanyl; Humans; Hypertension | 1991 |
[Anesthesia of a patient with hypertension, respiratory insufficiency and 2 occurrences of spontaneous pneumothorax for an arterial embolism of the lower extremity].
Topics: Aged; Anesthesia, Intravenous; Embolism; Humans; Hypertension; Ketamine; Leg; Male; Pneumothorax; Re | 1990 |
Ventricular tachycardia and hypotension with amniotic fluid embolism during cesarean section.
Topics: Adult; Anesthesia, Obstetrical; Blood Pressure; Bupivacaine; Cesarean Section; Diazepam; Electrocard | 1986 |
Ketamine in neurosurgical procedures.
Topics: Analgesics; Anesthesia, General; Child; Cyclohexanes; Humans; Hypertension; Injections, Intramuscula | 1971 |
The effects of droperidol on modifying the hypertensive response to ketamine.
Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Cardiac Output; Child; Dogs; Droperidol; Fema | 1974 |
Selective indications for ketamine anaesthesia.
Topics: Adult; Aged; Anesthesia, Dental; Anesthesia, General; Anesthesia, Spinal; Anesthetics; Burns; Cardia | 1971 |
[On some cardiocirculatory effects of ketamine in chloralose-treated dogs].
Topics: Anesthetics; Animals; Chloralose; Cyclohexanes; Dogs; Epinephrine; Heart; Hemodynamics; Hypertension | 1971 |
Study of ketamine as an obstetric anesthetic agent.
Topics: Adult; Anesthesia, Obstetrical; Anesthetics; Apgar Score; Bilirubin; Blood Pressure; Carbon Dioxide; | 1972 |
Study of ketamine as an obstetric anesthetic agent.
Topics: Adult; Anesthesia, Obstetrical; Anesthetics; Apgar Score; Bilirubin; Blood Pressure; Carbon Dioxide; | 1972 |
Study of ketamine as an obstetric anesthetic agent.
Topics: Adult; Anesthesia, Obstetrical; Anesthetics; Apgar Score; Bilirubin; Blood Pressure; Carbon Dioxide; | 1972 |
Study of ketamine as an obstetric anesthetic agent.
Topics: Adult; Anesthesia, Obstetrical; Anesthetics; Apgar Score; Bilirubin; Blood Pressure; Carbon Dioxide; | 1972 |
Ketamine. Indications, controversial special aspects, disadvantages.
Topics: Adult; Anesthesia; Anesthesia, Obstetrical; Animals; Blood Pressure; Child; Dogs; Dose-Response Rela | 1973 |
[Ketamine anesthesia by intravenous infusion. 1].
Topics: Adult; Anesthesia, Intravenous; Female; Humans; Hypertension; Ketamine; Middle Aged | 1973 |
Serum dopamine beta-hydroxylase activity as an index of sympathetic activity.
Topics: Adult; Aged; Anesthesia; Animals; Blood Pressure; Catecholamines; Child; Child, Preschool; Circadian | 1974 |
Clinical studies of induction agents. 38. Effect of premedicants and supplements on ketamine anaesthesia.
Topics: Adult; Analgesics; Anesthesia; Atropine; Benperidol; Blood Pressure; Cyclohexanes; Diazepam; Dreams; | 1971 |
[Experience with Ketalar anesthesia].
Topics: Anesthetics; Blood Pressure; Child; Cyclohexanes; Cyclopropanes; Female; Halothane; Humans; Hyperten | 1971 |
[Anesthesia with ketamines in surgery of the mouth, the jaw and the face].
Topics: Adolescent; Adult; Anesthesia, Dental; Anesthesia, General; Anesthetics; Blood Pressure; Cardiac Out | 1971 |
Problems with ketamine in adults.
Topics: Adult; Anesthetics; Benperidol; Cyclohexanes; Delirium; Diazepam; Humans; Hypertension; Injections, | 1971 |
Alarming reactions to ketamine in patients taking thyroid medication--treatment with propranolol.
Topics: Adult; Analgesics; Anesthesia, Intravenous; Cyclohexanes; Drug Synergism; Female; Humans; Hypertensi | 1971 |
Ketamine hydrochloride: a clinical investigation in 60 children.
Topics: Analgesics; Anesthetics; Child; Child, Preschool; Chlorides; Cyclohexanes; Humans; Hypertension; Inf | 1969 |