Page last updated: 2024-10-29

ketamine and Hypertension

ketamine has been researched along with Hypertension in 63 studies

Ketamine: A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.
ketamine : A member of the class of cyclohexanones in which one of the hydrogens at position 2 is substituted by a 2-chlorophenyl group, while the other is substituted by a methylamino group.

Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.

Research Excerpts

ExcerptRelevanceReference
"To compare the effect of an intravenous infusion of ketamine versus placebo on tourniquet induced hypertension in patients undergoing upper and lower limb surgery under general anaesthesia."9.24A randomized controlled trial to assess the effect of a ketamine infusion on tourniquet hypertension during general anaesthesia in patients undergoing upper and lower limb surgery. ( Kabugi, J; Mung'ayi, V; Ongaya, J; Sharif, T, 2017)
"Ketamine is considered a stable induction agent for rapid sequence induction; however, hypotension rates up to 24% are reported."7.83Hemodynamic Response After Rapid Sequence Induction With Ketamine in Out-of-Hospital Patients at Risk of Shock as Defined by the Shock Index. ( Burns, B; Habig, K; Heldreich, C; Kruit, N; Miller, M; Reid, C; Ware, S, 2016)
"Effects of Ca ion channel blockers, nicardipine, diltiazem and nifedipine on intraoperative hypertension were evaluated clinically in ninety surgical patients who received various surgical procedures under total intravenous anesthesia with droperidol, fentanyl and ketamine."7.68[Clinical study of total intravenous anesthesia with droperidol, fentanyl and ketamine--effects of nicardipine, diltiazem and nifedipine on intraoperative hypertension]. ( Hashimoto, Y; Hirota, K; Ishihara, H; Koh, H; Matsuki, A; Takagi, H, 1993)
" A case of hypertension and pulmonary oedema in such a patient, possibly triggered by ketamine, is reported."7.68Hypertension and pulmonary oedema associated with ketamine administration in a patient with a history of substance abuse. ( Murphy, JL, 1993)
"Intraoperative hypertension over 160 mmHg systolic and sinus tachycardia over 100 bpm are often observed during total intravenous anesthesia with droperidol, fentanyl and ketamine."7.68[Clinical study on total intravenous anesthesia with droperidol, fentanyl and ketamine--9. Control of intraoperative hypertension with diltiazem]. ( Ishihara, H; Kimura, F; Koh, H; Kushikata, T; Matsuki, A; Satoh, T, 1991)
"Intraoperative hypertension over 160 mmHg systolic observed during total intravenous anesthesia with droperidol, fentanyl and ketamine was treated with intravenous nicardipine in 50 surgical patients."7.68[Clinical study on total intravenous anesthesia with droperidol, fentanyl and ketamine--4. Control of intraoperative hypertension with nicardipine]. ( Amano, N; Hirota, K; Ishihara, H; Koh, H; Kotani, N; Matsuki, A, 1991)
"Ketamine appears to be a safe anesthetic option for children with PAH."5.36Perioperative complications in children with pulmonary hypertension undergoing general anesthesia with ketamine. ( Bair, E; Bratton, SL; Feinstein, JA; Hammer, GB; Kamra, K; Kuan, CC; Maan, H; Ramamoorthy, C; Williams, GD, 2010)
"To compare the overall occurrence of hypertension and tachycardia immediately pre-intubation (post-induction) until 10 minutes post intubation between the study group receiving fentanyl at 1."5.30Effect of low-dose ketamine versus fentanyl on attenuating the haemodynamic response to laryngoscopy and endotracheal intubation in patients undergoing general anaesthesia: a prospective, double-blinded, randomised controlled trial. ( Bal, R; Mung'ayi, V; Ongewe, A, 2019)
"To compare the effect of an intravenous infusion of ketamine versus placebo on tourniquet induced hypertension in patients undergoing upper and lower limb surgery under general anaesthesia."5.24A randomized controlled trial to assess the effect of a ketamine infusion on tourniquet hypertension during general anaesthesia in patients undergoing upper and lower limb surgery. ( Kabugi, J; Mung'ayi, V; Ongaya, J; Sharif, T, 2017)
" Ketamine:norketamine ratios were strongly positively correlated with change in dissociation ratings (r = 0."5.12Influence of formulation and route of administration on ketamine's safety and tolerability: systematic review. ( Glue, P; Medlicott, NJ; Russell, B, 2021)
"Ketamine, adverse effects, tachycardia, hypertension, postoperative pain, chronic postsurgical pain."4.31Effect of Analgesic Low-Dose Ketamine Infusions on the Cardiovascular Response: A Retrospective Analysis. ( Cadavid, AM; Calle, E; Camelo, JE; Casas, FD; Ramirez, CD; Tovar, A; Visbal, K, 2023)
"Ketamine is considered a stable induction agent for rapid sequence induction; however, hypotension rates up to 24% are reported."3.83Hemodynamic Response After Rapid Sequence Induction With Ketamine in Out-of-Hospital Patients at Risk of Shock as Defined by the Shock Index. ( Burns, B; Habig, K; Heldreich, C; Kruit, N; Miller, M; Reid, C; Ware, S, 2016)
" After administration of an intravenous dose of ketamine for fracture reduction, he developed severe hypertension."3.78Unexpected diagnosis of severe coarctation of the aorta after ketamine procedural sedation. ( Jiménez-Garcia, R; Perez-Garcia, MJ; Siles-Sanchez-Manjavacas, A, 2012)
" Combinations using an alpha2-adrenoceptor agonist and ketamine have been shown to be effective for immobilization but are not reversible and can produce severe hypertension and prolonged or rough recoveries."3.71Cardiorespiratory effects of medetomidine-butorphanol, medetomidine-butorphanol-diazepam, and medetomidine-butorphanol-ketamine in captive red wolves (Canis rufus). ( Horne, WA; Kelly, BT; Larsen, RS; Loomis, MR; Sladky, KK; Stoskopf, MK, 2002)
"Effects of Ca ion channel blockers, nicardipine, diltiazem and nifedipine on intraoperative hypertension were evaluated clinically in ninety surgical patients who received various surgical procedures under total intravenous anesthesia with droperidol, fentanyl and ketamine."3.68[Clinical study of total intravenous anesthesia with droperidol, fentanyl and ketamine--effects of nicardipine, diltiazem and nifedipine on intraoperative hypertension]. ( Hashimoto, Y; Hirota, K; Ishihara, H; Koh, H; Matsuki, A; Takagi, H, 1993)
" A case of hypertension and pulmonary oedema in such a patient, possibly triggered by ketamine, is reported."3.68Hypertension and pulmonary oedema associated with ketamine administration in a patient with a history of substance abuse. ( Murphy, JL, 1993)
"Intraoperative hypertension over 160 mmHg systolic and sinus tachycardia over 100 bpm are often observed during total intravenous anesthesia with droperidol, fentanyl and ketamine."3.68[Clinical study on total intravenous anesthesia with droperidol, fentanyl and ketamine--9. Control of intraoperative hypertension with diltiazem]. ( Ishihara, H; Kimura, F; Koh, H; Kushikata, T; Matsuki, A; Satoh, T, 1991)
"Intraoperative hypertension over 160 mmHg systolic observed during total intravenous anesthesia with droperidol, fentanyl and ketamine was treated with intravenous nicardipine in 50 surgical patients."3.68[Clinical study on total intravenous anesthesia with droperidol, fentanyl and ketamine--4. Control of intraoperative hypertension with nicardipine]. ( Amano, N; Hirota, K; Ishihara, H; Koh, H; Kotani, N; Matsuki, A, 1991)
"9% saline (placebo) in combination with ketamine and rocuronium, according to a weight-based dosing schedule."3.11Fentanyl versus placebo with ketamine and rocuronium for patients undergoing rapid sequence intubation in the emergency department: The FAKT study-A randomized clinical trial. ( Aneman, A; Burns, B; Buttfield, A; Ferguson, I; Harris, IA; Milligan, J; Reid, C; Shepherd, S, 2022)
"We observed that respiratory depression (19."2.82Propofol-ketamine combination: a choice with less complications and better hemodynamic stability compared to propofol? On a prospective study in a group of colonoscopy patients. ( Babayıgıt, M; Baykal Tutal, Z; Derelı, N; Gulec, H; Horasanlı, E; Inceoz, H; Kurtay, A, 2016)
"To evaluate the anesthetic and cardiopulmonary effects of ketamine-dexmedetomidine combined with local anesthesia, associated or not in the postoperative period with different doses of atipamezole, for orchiectomy in cats."1.72Ketamine-dexmedetomidine combined with local anesthesia, with or without different doses of atipamezole in the postoperative period, for orchiectomy in cats. ( Cappelli, N; da Silva, MFA; de Carvalho, WTS; Gomes, VH; Mignani, BTG; Pimentel, VC, 2022)
"esketamine injections were mild and well tolerated for doses up to 1 mg/kg."1.56Effects of subcutaneous esketamine on blood pressure and heart rate in treatment-resistant depression. ( Abdo, G; Barbosa, M; Cohrs, FM; de Jesus Mari, J; Del Porto, JA; Del Sant, LC; Delfino, R; Fava, VAR; Lacerda, ALT; Liberatori, A; Lucchese, AC; Magalhães, EJM; Nakahira, C; Sarin, LM; Steiglich, MS; Surjan, J; Tuena, MA, 2020)
"Ketamine appears to be a safe anesthetic option for children with PAH."1.36Perioperative complications in children with pulmonary hypertension undergoing general anesthesia with ketamine. ( Bair, E; Bratton, SL; Feinstein, JA; Hammer, GB; Kamra, K; Kuan, CC; Maan, H; Ramamoorthy, C; Williams, GD, 2010)
"Hypertension was present in all groups during anaesthesia with mean (+/- SD) systolic pressure of 30."1.33Cardiopulmonary effects of medetomidine or midazolam in combination with ketamine or tiletamine/zolazepam for the immobilisation of captive cheetahs (Acinonyx jubatus). ( Jago, M; Stegmann, GF, 2006)
"Hypertension was recorded in 11."1.28A retrospective survey of anaesthesia in horses with colic. ( Adams, JG; Cowgill, LM; Trim, CM; Ward, SL, 1989)

Research

Studies (63)

TimeframeStudies, this research(%)All Research%
pre-199026 (41.27)18.7374
1990's10 (15.87)18.2507
2000's6 (9.52)29.6817
2010's14 (22.22)24.3611
2020's7 (11.11)2.80

Authors

AuthorsStudies
Huang, TL1
Mayence, A1
Vanden Eynde, JJ1
Ferguson, I1
Buttfield, A1
Burns, B2
Reid, C2
Shepherd, S1
Milligan, J1
Harris, IA1
Aneman, A1
Gomes, VH3
de Carvalho, WTS3
Pimentel, VC3
Cappelli, N3
Mignani, BTG3
da Silva, MFA3
Cadavid, AM1
Casas, FD1
Camelo, JE1
Tovar, A1
Ramirez, CD1
Calle, E1
Visbal, K1
Ongewe, A1
Mung'ayi, V2
Bal, R1
Del Sant, LC1
Sarin, LM1
Magalhães, EJM1
Lucchese, AC1
Tuena, MA1
Nakahira, C1
Fava, VAR1
Delfino, R1
Surjan, J1
Steiglich, MS1
Barbosa, M1
Abdo, G1
Cohrs, FM1
Liberatori, A1
Del Porto, JA1
Lacerda, ALT1
de Jesus Mari, J1
Glue, P1
Russell, B1
Medlicott, NJ1
McIntyre, RS1
Rosenblat, JD1
Nemeroff, CB1
Sanacora, G1
Murrough, JW1
Berk, M1
Brietzke, E1
Dodd, S1
Gorwood, P1
Ho, R1
Iosifescu, DV1
Lopez Jaramillo, C1
Kasper, S1
Kratiuk, K1
Lee, JG1
Lee, Y1
Lui, LMW1
Mansur, RB1
Papakostas, GI1
Subramaniapillai, M1
Thase, M1
Vieta, E1
Young, AH1
Zarate, CA1
Stahl, S1
Raisis, AL1
Mosing, M1
Hosgood, GL1
Secombe, CJ1
Adler, A1
Waldmann, AD1
Ongaya, J1
Sharif, T1
Kabugi, J1
Shah, P1
McDowell, M1
Ebisu, R1
Hanif, T1
Toerne, T1
Tang, MHY1
Chong, YK1
Chan, CY1
Ching, CK1
Lai, CK1
Li, YK1
Mak, TWL1
Stemmet, GP1
Meyer, LC1
Bruns, A1
Buss, P1
Zimmerman, D1
Koeppel, K1
Zeiler, GE1
Bencze, M1
Behuliak, M1
Zicha, J1
van Hecke, O1
Guthrie, B1
Baykal Tutal, Z1
Gulec, H1
Derelı, N1
Babayıgıt, M1
Kurtay, A1
Inceoz, H1
Horasanlı, E1
Miller, M1
Kruit, N1
Heldreich, C1
Ware, S1
Habig, K1
Burmon, C1
Adamakos, F1
Filardo, M1
Motov, S1
Williams, GD1
Maan, H1
Ramamoorthy, C1
Kamra, K1
Bratton, SL1
Bair, E1
Kuan, CC1
Hammer, GB1
Feinstein, JA1
Hofer, KE1
Grager, B1
Müller, DM1
Rauber-Lüthy, C1
Kupferschmidt, H1
Rentsch, KM1
Ceschi, A1
Perez-Garcia, MJ1
Jiménez-Garcia, R1
Siles-Sanchez-Manjavacas, A1
Larsen, RS1
Loomis, MR1
Kelly, BT1
Sladky, KK1
Stoskopf, MK1
Horne, WA1
Neema, PK1
Unnikrishnan, M1
Sinha, PK1
Rathod, RC1
Brookes, ZL1
Reilly, CS1
Brown, NJ1
Stegmann, GF1
Jago, M1
Broughton Pipkin, F1
Waldron, BA1
Altura, BM1
Altura, BT1
Baer, G1
Rorarius, M1
Schavikin, L1
Väyrynen, T1
Kudo, T1
Kudo, M1
Hashimoto, H1
Koh, H4
Ishihara, H4
Matsuki, A4
Tanaka, M1
Nishikawa, T1
Nitschke, T1
Munro, HM1
Sleigh, JW1
Paxton, LD1
Hashimoto, Y1
Takagi, H1
Hirota, K2
Murphy, JL1
Trim, CM1
Adams, JG1
Cowgill, LM1
Ward, SL1
van Gorp, AW1
Schenau, DS1
Hoeks, AP1
Boudier, HA1
de Mey, JG1
Reneman, RS1
Satsumae, T1
Yamaguchi, H1
Sakaguchi, M1
Yasunaga, T1
Yamashita, S1
Yamamoto, S1
Kida, H1
Dauri, A1
Colace, F1
Bellanca, T1
Bertolini, G1
Mendenhall, MK1
Ahlgren, EW1
Reves, JG1
Lell, WA1
McCracken, LE1
Kravetz, RA1
Prough, DS1
Juan Vicente, A1
Pedraz de Cabo, J1
Elliott, E1
Hanid, TK1
Arthur, LJ1
Kay, B1
Reyes Toso, CF1
Linares, LM1
Rodríguez, RR1
Kimura, F1
Kushikata, T1
Satoh, T1
Amano, N1
Kotani, N1
Gregoriades, SA1
Shah, K1
Karlman, R1
Heller, J1
Evans, J1
Rosen, M1
Weeks, RD1
Wise, C1
Wilson, RD1
Ashy, TM1
Allen, CR1
Priano, LL1
Dundee, JW3
Bovill, J1
Szappanyos, G1
Gemperle, M1
Rifat, K1
Constantin, B1
Condat, P1
Jourde, M1
Condat, M1
Lapalus, P1
Little, B1
Chang, T1
Chucot, L1
Dill, WA1
Enrile, LL1
Glazko, AJ1
Jassani, M1
Kretchmer, H1
Sweet, AY1
Hunter, AR1
Langrehr, D1
Neuhaus, R1
Tamiya, K1
Yamazaki, T1
Kawabata, Y1
Yasukawa, K1
Nanba, M1
Leon, AS1
Thomas, PE1
Sernatinger, E1
Canlas, A1
Bovill, JG2
Clarke, RS2
Pandit, SK2
Moore, J1
Dalsgård, M1
Thorshauge, C1
Brockmüller, KD1
Kaplan, JA1
Cooperman, LH1
Ginsberg, H1
Gerber, JA1

Clinical Trials (5)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effect of Intravenous Low-dose Esketamine on Maternal Depression at 2 Years After Childbirth in Women With Prenatal Depression: 2-year Follow-up of a Randomized Controlled Trial[NCT05698394]Phase 4364 participants (Actual)Interventional2020-06-19Active, not recruiting
Phenomenological Explorations of the Esketamine-Induced Transient Dissociative State[NCT06133309]15 participants (Anticipated)Interventional2023-12-01Not yet recruiting
Prospective Study of Induction Medications Used in the Rapid Sequence Intubation of Trauma Patients and a Comparison of Effects on Outcomes[NCT04291521]7,000 participants (Anticipated)Observational2024-01-01Not yet recruiting
The Pharmacokinetics of Ketamine in the Breast Milk of Lactating Women: Quantification of Ketamine and Metabolites[NCT04285684]Early Phase 14 participants (Actual)Interventional2019-12-20Completed
Conscious Dying/Conscious Living: Ketamine-Assisted Psychotherapy (KAP) for Patients at End of Life-A Pilot Study for Palliative and Hospice Care[NCT05214417]Phase 2120 participants (Anticipated)Interventional2022-05-01Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Dehydronorketamine Concentration in Breast Milk at 24 and 30 Hours After an IM Administration of 1mg/kg Ketamine

"Quantitative analysis of the concentration of ketamine and its metabolites in breast milk (collected by pumping breast milk into containers at 24 and 30 hours post ketamine IM administration) was performed at the Clinical Medicine and Toxicology Laboratory at UCSF School of Medicine. Sample aliquots were frozen in our conventional freezer at the clinic where the sessions took place, labelled with a HIPAA compliant code which blinded the lab to all patient data.~The limits of sensitivity for the quantification of each substance were:~Ketamine: 0.25 ng Norketamine: 0.25 ng Dehydronorketamine: 0.1 ng Hydroxynorketamine: 0.25 ng" (NCT04285684)
Timeframe: 24 and 30 hour collections

Interventionng/mL (Mean)
24 Hours30 Hours
Ketamine During Lactation.3.3

Dehydronorketamine Concentration in Breast Milk, up to 12 Hours at 3 Hour Intervals, Following an IM Administration of .5mg/kg Ketamine

"Quantitative analysis of the concentration of ketamine and its metabolites in breast milk (collected by pumping breast milk into containers at 3, 6, 9, and 12 hours post ketamine IM administration) was performed at the Clinical Medicine and Toxicology Laboratory at UCSF School of Medicine. Sample aliquots were frozen in our conventional freezer at the clinic where the sessions took place, labelled with a HIPAA compliant code which blinded the lab to all patient data.~The limits of sensitivity for the quantification of each substance were:~Ketamine: 0.25 ng Norketamine: 0.25 ng Dehydronorketamine: 0.1 ng Hydroxynorketamine: 0.25 ng" (NCT04285684)
Timeframe: 3, 6, 9, and 12 hour collections

Interventionng/mL (Mean)
3 Hours6 Hours9 Hours12 Hours
Ketamine During Lactation.56.55.45.21

Dehydronorketamine Concentration in Breast Milk, up to 12 Hours at 3 Hour Intervals, Following an IM Administration of 1mg/kg Ketamine

"Quantitative analysis of the concentration of ketamine and its metabolites in breast milk (collected by pumping breast milk into containers at 3, 6, 9, and 12 hours post ketamine IM administration) was performed at the Clinical Medicine and Toxicology Laboratory at UCSF School of Medicine. Sample aliquots were frozen in our conventional freezer at the clinic where the sessions took place, labelled with a HIPAA compliant code which blinded the lab to all patient data.~The limits of sensitivity for the quantification of each substance were:~Ketamine: 0.25 ng Norketamine: 0.25 ng Dehydronorketamine: 0.1 ng Hydroxynorketamine: 0.25 ng" (NCT04285684)
Timeframe: 3, 6, 9, and 12 hour collections

Interventionng/mL (Mean)
3 Hours6 Hours9 Hours12 Hours
Ketamine During Lactation2.01.91.41.1

Hydroxynorketamine Concentration in Breast Milk at 24 and 30 Hours After an IM Administration of 1mg/kg Ketamine

"Quantitative analysis of the concentration of ketamine and its metabolites in breast milk (collected by pumping breast milk into containers at 24 and 30 hours post ketamine IM administration) was performed at the Clinical Medicine and Toxicology Laboratory at UCSF School of Medicine. Sample aliquots were frozen in our conventional freezer at the clinic where the sessions took place, labelled with a HIPAA compliant code which blinded the lab to all patient data.~The limits of sensitivity for the quantification of each substance were:~Ketamine: 0.25 ng Norketamine: 0.25 ng Dehydronorketamine: 0.1 ng Hydroxynorketamine: 0.25 ng" (NCT04285684)
Timeframe: 24 and 30 hour collections

Interventionng/mL (Mean)
24 Hours30 Hours
Ketamine During Lactation30.513.9

Hydroxynorketamine Concentration in Breast Milk, up to 12 Hours at 3 Hour Intervals, Following an IM Administration of .5mg/kg Ketamine

"Quantitative analysis of the concentration of ketamine and its metabolites in breast milk (collected by pumping breast milk into containers at 3, 6, 9, and 12 hours post ketamine IM administration) was performed at the Clinical Medicine and Toxicology Laboratory at UCSF School of Medicine. Sample aliquots were frozen in our conventional freezer at the clinic where the sessions took place, labelled with a HIPAA compliant code which blinded the lab to all patient data.~The limits of sensitivity for the quantification of each substance were:~Ketamine: 0.25 ng Norketamine: 0.25 ng Dehydronorketamine: 0.1 ng Hydroxynorketamine: 0.25 ng" (NCT04285684)
Timeframe: 3, 6, 9, and 12 hour collections

Interventionng/mL (Mean)
3 Hours6 Hours9 Hours12 Hours
Ketamine During Lactation29.928.325.617.5

Hydroxynorketamine Concentration in Breast Milk, up to 12 Hours at 3 Hour Intervals, Following an IM Administration of 1mg/kg Ketamine

"Quantitative analysis of the concentration of ketamine and its metabolites in breast milk (collected by pumping breast milk into containers at 3, 6, 9, and 12 hours post ketamine IM administration) was performed at the Clinical Medicine and Toxicology Laboratory at UCSF School of Medicine. Sample aliquots were frozen in our conventional freezer at the clinic where the sessions took place, labelled with a HIPAA compliant code which blinded the lab to all patient data.~The limits of sensitivity for the quantification of each substance were:~Ketamine: 0.25 ng Norketamine: 0.25 ng Dehydronorketamine: 0.1 ng Hydroxynorketamine: 0.25 ng" (NCT04285684)
Timeframe: 3, 6, 9, and 12 hour collections

Interventionng/mL (Mean)
3 Hours6 Hours9 Hours12 Hours
Ketamine During Lactation64.166.954.641.6

Ketamine Concentration in Breast Milk at 24 and 30 Hours After an IM Administration of 1mg/kg Ketamine

"Quantitative analysis of the concentration of ketamine and its metabolites in breast milk (collected by pumping breast milk into containers at 24 and 30 hours post ketamine IM administration) was performed at the Clinical Medicine and Toxicology Laboratory at UCSF School of Medicine. Sample aliquots were frozen in our conventional freezer at the clinic where the sessions took place, labelled with a HIPAA compliant code which blinded the lab to all patient data.~The limits of sensitivity for the quantification of each substance were:~Ketamine: 0.25 ng Norketamine: 0.25 ng Dehydronorketamine: 0.1 ng Hydroxynorketamine: 0.25 ng" (NCT04285684)
Timeframe: 24 and 30 hour collections

Interventionng/mL (Mean)
24 Hours30 Hours
Ketamine During Lactation4.96.4

Ketamine Concentration in Breast Milk, up to 12 Hours at 3 Hour Intervals, Following an IM Administration of .5mg/kg Ketamine

"Quantitative analysis of the concentration of ketamine and its metabolites in breast milk (collected by pumping breast milk into containers at 3, 6, 9, and 12 hours post ketamine IM administration) was performed at the Clinical Medicine and Toxicology Laboratory at UCSF School of Medicine. Sample aliquots were frozen in our conventional freezer at the clinic where the sessions took place, labelled with a HIPAA compliant code which blinded the lab to all patient data.~The limits of sensitivity for the quantification of each substance were:~Ketamine: 0.25 ng Norketamine: 0.25 ng Dehydronorketamine: 0.1 ng Hydroxynorketamine: 0.25 ng" (NCT04285684)
Timeframe: 3, 6, 9, and 12 hour collections

Interventionng/mL (Mean)
3 Hours6 Hours9 Hours12 Hours
Ketamine During Lactation51.222.610.64.5

Ketamine Concentration in Breast Milk, up to 12 Hours at 3 Hour Intervals, Following an IM Administration of 1mg/kg Ketamine

"Quantitative analysis of the concentration of ketamine and its metabolites in breast milk (collected by pumping breast milk into containers at 3, 6, 9, and 12 hours post ketamine IM administration) was performed at the Clinical Medicine and Toxicology Laboratory at UCSF School of Medicine. Sample aliquots were frozen in our conventional freezer at the clinic where the sessions took place, labelled with a HIPAA compliant code which blinded the lab to all patient data.~The limits of sensitivity for the quantification of each substance were:~Ketamine: 0.25 ng Norketamine: 0.25 ng Dehydronorketamine: 0.1 ng Hydroxynorketamine: 0.25 ng" (NCT04285684)
Timeframe: 3, 6, 9, and 12 hour collections

Interventionng/mL (Mean)
3 Hours6 Hours9 Hours12 Hours
Ketamine During Lactation125.048.221.618.5

Norketamine Concentration in Breast Milk at 24 and 30 Hours After an IM Administration of 1mg/kg Ketamine

"Quantitative analysis of the concentration of ketamine and its metabolites in breast milk (collected by pumping breast milk into containers at 24 and 30 hours post ketamine IM administration) was performed at the Clinical Medicine and Toxicology Laboratory at UCSF School of Medicine. Sample aliquots were frozen in our conventional freezer at the clinic where the sessions took place, labelled with a HIPAA compliant code which blinded the lab to all patient data.~The limits of sensitivity for the quantification of each substance were:~Ketamine: 0.25 ng Norketamine: 0.25 ng Dehydronorketamine: 0.1 ng Hydroxynorketamine: 0.25 ng" (NCT04285684)
Timeframe: 24 and 30 hour collections

Interventionng/mL (Mean)
24 Hours30 Hours
Ketamine During Lactation10.39.9

Norketamine Concentration in Breast Milk, up to 12 Hours at 3 Hour Intervals, Following an IM Administration of .5mg/kg Ketamine

"Quantitative analysis of the concentration of ketamine and its metabolites in breast milk (collected by pumping breast milk into containers at 3, 6, 9, and 12 hours post ketamine IM administration) was performed at the Clinical Medicine and Toxicology Laboratory at UCSF School of Medicine. Sample aliquots were frozen in our conventional freezer at the clinic where the sessions took place, labelled with a HIPAA compliant code which blinded the lab to all patient data.~The limits of sensitivity for the quantification of each substance were:~Ketamine: 0.25 ng Norketamine: 0.25 ng Dehydronorketamine: 0.1 ng Hydroxynorketamine: 0.25 ng" (NCT04285684)
Timeframe: 3, 6, 9, and 12 hour collections

Interventionng/mL (Mean)
3 Hours6 Hours9 Hours12 Hours
Ketamine During Lactation42.628.618.88.7

Norketamine Concentration in Breast Milk, up to 12 Hours at 3 Hour Intervals, Following an IM Administration of 1mg/kg Ketamine

"Quantitative analysis of the concentration of ketamine and its metabolites in breast milk (collected by pumping breast milk into containers at 3, 6, 9, and 12 hours post ketamine IM administration) was performed at the Clinical Medicine and Toxicology Laboratory at UCSF School of Medicine. Sample aliquots were frozen in our conventional freezer at the clinic where the sessions took place, labelled with a HIPAA compliant code which blinded the lab to all patient data.~The limits of sensitivity for the quantification of each substance were:~Ketamine: 0.25 ng Norketamine: 0.25 ng Dehydronorketamine: 0.1 ng Hydroxynorketamine: 0.25 ng" (NCT04285684)
Timeframe: 3, 6, 9, and 12 hour collections

Interventionng/mL (Mean)
3 Hours6 Hours9 Hours12 Hours
Ketamine During Lactation92.762.437.332.3

Reviews

5 reviews available for ketamine and Hypertension

ArticleYear
Some non-conventional biomolecular targets for diamidines. A short survey.
    Bioorganic & medicinal chemistry, 2014, Apr-01, Volume: 22, Issue:7

    Topics: Amidines; Animals; Diabetes Mellitus, Type 2; DNA; Enzymes; Humans; Hypertension; Ion Channels; Myot

2014
Influence of formulation and route of administration on ketamine's safety and tolerability: systematic review.
    European journal of clinical pharmacology, 2021, Volume: 77, Issue:5

    Topics: Antidepressive Agents; Dissociative Disorders; Drug Administration Routes; Drug Delivery Systems; Hu

2021
Synthesizing the Evidence for Ketamine and Esketamine in Treatment-Resistant Depression: An International Expert Opinion on the Available Evidence and Implementation.
    The American journal of psychiatry, 2021, 05-01, Volume: 178, Issue:5

    Topics: Antidepressive Agents; Delivery of Health Care; Depressive Disorder, Major; Depressive Disorder, Tre

2021
Synthesizing the Evidence for Ketamine and Esketamine in Treatment-Resistant Depression: An International Expert Opinion on the Available Evidence and Implementation.
    The American journal of psychiatry, 2021, 05-01, Volume: 178, Issue:5

    Topics: Antidepressive Agents; Delivery of Health Care; Depressive Disorder, Major; Depressive Disorder, Tre

2021
Synthesizing the Evidence for Ketamine and Esketamine in Treatment-Resistant Depression: An International Expert Opinion on the Available Evidence and Implementation.
    The American journal of psychiatry, 2021, 05-01, Volume: 178, Issue:5

    Topics: Antidepressive Agents; Delivery of Health Care; Depressive Disorder, Major; Depressive Disorder, Tre

2021
Synthesizing the Evidence for Ketamine and Esketamine in Treatment-Resistant Depression: An International Expert Opinion on the Available Evidence and Implementation.
    The American journal of psychiatry, 2021, 05-01, Volume: 178, Issue:5

    Topics: Antidepressive Agents; Delivery of Health Care; Depressive Disorder, Major; Depressive Disorder, Tre

2021
Microcirculatory actions and uses of naturally-occurring (magnesium) and novel synthetic calcium channel blockers.
    Microcirculation, endothelium, and lymphatics, 1984, Volume: 1, Issue:2

    Topics: Anesthesia; Animals; Arterioles; Blood Pressure; Calcium; Calcium Channel Blockers; Cell Membrane Pe

1984
Drugs for producing dissociative states.
    International anesthesiology clinics, 1973,Spring, Volume: 11, Issue:1

    Topics: Anesthesia, Dental; Anesthetics; Anesthetics, Dissociative; Brain Diseases; Cardiac Catheterization;

1973

Trials

11 trials available for ketamine and Hypertension

ArticleYear
Fentanyl versus placebo with ketamine and rocuronium for patients undergoing rapid sequence intubation in the emergency department: The FAKT study-A randomized clinical trial.
    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2022, Volume: 29, Issue:6

    Topics: Australia; Emergency Service, Hospital; Fentanyl; Humans; Hypertension; Hypotension; Intubation, Int

2022
Effect of low-dose ketamine versus fentanyl on attenuating the haemodynamic response to laryngoscopy and endotracheal intubation in patients undergoing general anaesthesia: a prospective, double-blinded, randomised controlled trial.
    African health sciences, 2019, Volume: 19, Issue:3

    Topics: Adolescent; Adult; Age Factors; Aged; Anesthetics; Double-Blind Method; Elective Surgical Procedures

2019
A randomized controlled trial to assess the effect of a ketamine infusion on tourniquet hypertension during general anaesthesia in patients undergoing upper and lower limb surgery.
    African health sciences, 2017, Volume: 17, Issue:1

    Topics: Adult; Analgesics; Anesthesia, General; Blood Pressure; Double-Blind Method; Female; Heart Rate; Hem

2017
Compared to etorphine-azaperone, the ketamine-butorphanol-medetomidine combination is also effective at immobilizing zebra (Equus zebra).
    Veterinary anaesthesia and analgesia, 2019, Volume: 46, Issue:4

    Topics: Analgesics, Opioid; Anesthetics, Dissociative; Animals; Animals, Wild; Azaperone; Blood Pressure; Bu

2019
Propofol-ketamine combination: a choice with less complications and better hemodynamic stability compared to propofol? On a prospective study in a group of colonoscopy patients.
    Irish journal of medical science, 2016, Volume: 185, Issue:3

    Topics: Anesthetics, Combined; Colonoscopy; Double-Blind Method; Female; Heart Rate; Humans; Hypertension; H

2016
[Endocrine effects of nicardipine on intraoperative hypertension under droperidol-fentanyl-ketamine (DFK) anesthesia].
    Masui. The Japanese journal of anesthesiology, 1995, Volume: 44, Issue:4

    Topics: Adult; Aged; Aldosterone; Anesthesia, Intravenous; Atrial Natriuretic Factor; Catecholamines; Droper

1995
Oral clonidine premedication attenuates the hypertensive response to ketamine.
    British journal of anaesthesia, 1994, Volume: 73, Issue:6

    Topics: Administration, Oral; Adolescent; Adult; Anesthesia, Intravenous; Blood Pressure; Clonidine; Female;

1994
The cardiovascular response to ketamine: the effects of clonidine and lignocaine.
    Acta anaesthesiologica Scandinavica, 1993, Volume: 37, Issue:1

    Topics: Adult; Aged; Clonidine; Double-Blind Method; Female; Humans; Hypertension; Ketamine; Lidocaine; Male

1993
Preoperative small-dose ketamine prevented tourniquet-induced arterial pressure increase in orthopedic patients under general anesthesia.
    Anesthesia and analgesia, 2001, Volume: 92, Issue:5

    Topics: Adolescent; Adult; Aged; Analgesics; Anesthesia, General; Blood Pressure; Double-Blind Method; Femal

2001
Comparison of morphine and ketamine anesthetic technics for coronary surgery: a randomized study.
    Southern medical journal, 1978, Volume: 71, Issue:1

    Topics: Adult; Aged; Anesthetics; Arrhythmias, Cardiac; Diazepam; Hemodynamics; Humans; Hypertension; Ketami

1978
Ketamine.
    Lancet (London, England), 1970, Aug-08, Volume: 2, Issue:7667

    Topics: Analgesics; Anesthetics; Atropine; Clinical Trials as Topic; Cyclohexanes; Delirium; Humans; Hyperte

1970

Other Studies

47 other studies available for ketamine and Hypertension

ArticleYear
Ketamine-dexmedetomidine combined with local anesthesia, with or without different doses of atipamezole in the postoperative period, for orchiectomy in cats.
    Journal of the American Veterinary Medical Association, 2022, 12-01, Volume: 261, Issue:2

    Topics: Anesthesia, Local; Anesthetics; Animals; Cat Diseases; Cats; Dexmedetomidine; Hypertension; Ketamine

2022
Ketamine-dexmedetomidine combined with local anesthesia, with or without different doses of atipamezole in the postoperative period, for orchiectomy in cats.
    Journal of the American Veterinary Medical Association, 2022, 12-01, Volume: 261, Issue:2

    Topics: Anesthesia, Local; Anesthetics; Animals; Cat Diseases; Cats; Dexmedetomidine; Hypertension; Ketamine

2022
Ketamine-dexmedetomidine combined with local anesthesia, with or without different doses of atipamezole in the postoperative period, for orchiectomy in cats.
    Journal of the American Veterinary Medical Association, 2022, 12-01, Volume: 261, Issue:2

    Topics: Anesthesia, Local; Anesthetics; Animals; Cat Diseases; Cats; Dexmedetomidine; Hypertension; Ketamine

2022
Ketamine-dexmedetomidine combined with local anesthesia, with or without different doses of atipamezole in the postoperative period, for orchiectomy in cats.
    Journal of the American Veterinary Medical Association, 2022, 12-01, Volume: 261, Issue:2

    Topics: Anesthesia, Local; Anesthetics; Animals; Cat Diseases; Cats; Dexmedetomidine; Hypertension; Ketamine

2022
Effect of Analgesic Low-Dose Ketamine Infusions on the Cardiovascular Response: A Retrospective Analysis.
    Pain physician, 2023, Volume: 26, Issue:5

    Topics: Acute Pain; Adult; Analgesics; Analgesics, Opioid; Humans; Hypertension; Ketamine; Pain, Postoperati

2023
Effects of subcutaneous esketamine on blood pressure and heart rate in treatment-resistant depression.
    Journal of psychopharmacology (Oxford, England), 2020, Volume: 34, Issue:10

    Topics: Adult; Antidepressive Agents; Blood Pressure; Cohort Studies; Depressive Disorder, Treatment-Resista

2020
The use of electrical impedance tomography (EIT) to evaluate pulse rate in anaesthetised horses.
    Veterinary journal (London, England : 1997), 2021, Volume: 273

    Topics: Anesthesia; Anesthetics, Intravenous; Animals; Diazepam; Electric Impedance; Heart Rate; Horses; Hyp

2021
Adjunctive Use of Ketamine for Benzodiazepine-Resistant Severe Alcohol Withdrawal: a Retrospective Evaluation.
    Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2018, Volume: 14, Issue:3

    Topics: Adult; Aged; Alcohol Withdrawal Seizures; Benzodiazepines; Blood Alcohol Content; Central Nervous Sy

2018
Cluster of acute poisonings associated with an emerging ketamine analogue, 2-oxo-PCE.
    Forensic science international, 2018, Volume: 290

    Topics: Adult; Chromatography, Liquid; Confusion; Consciousness Disorders; Female; Forensic Toxicology; Gas

2018
The impact of four different classes of anesthetics on the mechanisms of blood pressure regulation in normotensive and spontaneously hypertensive rats.
    Physiological research, 2013, Volume: 62, Issue:5

    Topics: Anesthetics; Anesthetics, Combined; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressur

2013
Oral ketamine analgesia in chronic pain and problematic rise in blood pressure.
    BMJ case reports, 2014, Nov-25, Volume: 2014

    Topics: Aged; Analgesics; Chronic Pain; Female; Humans; Hypertension; Ketamine; Low Back Pain

2014
Hemodynamic Response After Rapid Sequence Induction With Ketamine in Out-of-Hospital Patients at Risk of Shock as Defined by the Shock Index.
    Annals of emergency medicine, 2016, Volume: 68, Issue:2

    Topics: Adult; Aged; Analgesics; Blood Pressure; Craniocerebral Trauma; Emergency Medical Services; Female;

2016
Acute pulmonary edema associated with ketamine-induced hypertension during procedural sedation in the ED.
    The American journal of emergency medicine, 2017, Volume: 35, Issue:3

    Topics: Acute Disease; Anesthetics, Dissociative; Anti-Bacterial Agents; Arthralgia; Arthrocentesis; Cardiop

2017
Perioperative complications in children with pulmonary hypertension undergoing general anesthesia with ketamine.
    Paediatric anaesthesia, 2010, Volume: 20, Issue:1

    Topics: Adolescent; Anesthesia, General; Anesthetics, Dissociative; Blood Pressure; Cardiac Surgical Procedu

2010
Ketamine-like effects after recreational use of methoxetamine.
    Annals of emergency medicine, 2012, Volume: 60, Issue:1

    Topics: Anesthetics, Dissociative; Confusion; Cyclohexanones; Cyclohexylamines; Dyskinesias; Humans; Hyperte

2012
Unexpected diagnosis of severe coarctation of the aorta after ketamine procedural sedation.
    Pediatric emergency care, 2012, Volume: 28, Issue:11

    Topics: Anesthetics, Dissociative; Aortic Coarctation; Child; Forearm Injuries; Humans; Hypertension; Ketami

2012
Cardiorespiratory effects of medetomidine-butorphanol, medetomidine-butorphanol-diazepam, and medetomidine-butorphanol-ketamine in captive red wolves (Canis rufus).
    Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians, 2002, Volume: 33, Issue:2

    Topics: Adrenergic alpha-Antagonists; Anesthetics, Dissociative; Animals; Animals, Zoo; Blood Pressure; Body

2002
Anesthetic management for a hypertensive patent ductus arteriosus (PDA) closure in a patient with surgically uncorrectable long-segment right pulmonary artery hypoplasia and a ventricular septal defect.
    Journal of cardiothoracic and vascular anesthesia, 2003, Volume: 17, Issue:6

    Topics: Analgesics; Anesthesia; Anesthetics, Inhalation; Anesthetics, Intravenous; Child, Preschool; Ductus

2003
Differential effects of propofol, ketamine, and thiopental anaesthesia on the skeletal muscle microcirculation of normotensive and hypertensive rats in vivo.
    British journal of anaesthesia, 2004, Volume: 93, Issue:2

    Topics: Anesthetics, Dissociative; Anesthetics, Intravenous; Animals; Arterioles; Dose-Response Relationship

2004
Cardiopulmonary effects of medetomidine or midazolam in combination with ketamine or tiletamine/zolazepam for the immobilisation of captive cheetahs (Acinonyx jubatus).
    Journal of the South African Veterinary Association, 2006, Volume: 77, Issue:4

    Topics: Acinonyx; Anesthetics, Combined; Animals; Blood Gas Analysis; Heart Rate; Hypertension; Immobilizati

2006
Ketamine hypertension and the renin-angiotensin system.
    Clinical and experimental hypertension. Part A, Theory and practice, 1983, Volume: 5, Issue:6

    Topics: Adult; Aldosterone; Angiotensin II; Blood Pressure; Female; Humans; Hypertension; Ketamine; Renin; R

1983
[Recovery after ketamine-diazepam and thiopental-fentanyl-infusion anesthesia with jet-ventilation for laryngomicroscopy].
    Der Anaesthesist, 1983, Volume: 32, Issue:3

    Topics: Adult; Aged; Anesthesia, Intravenous; Blood Pressure; Diazepam; Female; Fentanyl; Humans; Hypertensi

1983
[Treatment of intraoperative status asthmaticus with ketamine].
    Anaesthesiologie und Reanimation, 1994, Volume: 19, Issue:3

    Topics: Airway Resistance; Alfentanil; Anesthesia, General; Breast Neoplasms; Female; Humans; Hypertension;

1994
[Clinical study of total intravenous anesthesia with droperidol, fentanyl and ketamine--effects of nicardipine, diltiazem and nifedipine on intraoperative hypertension].
    Masui. The Japanese journal of anesthesiology, 1993, Volume: 42, Issue:2

    Topics: Anesthesia, Intravenous; Calcium Channel Blockers; Diltiazem; Droperidol; Female; Fentanyl; Humans;

1993
Hypertension and pulmonary oedema associated with ketamine administration in a patient with a history of substance abuse.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1993, Volume: 40, Issue:2

    Topics: Adult; Anesthesia, Intravenous; Anesthesia, Spinal; Crack Cocaine; Female; Humans; Hypertension; Ket

1993
A retrospective survey of anaesthesia in horses with colic.
    Equine veterinary journal. Supplement, 1989, Issue:7

    Topics: Administration, Inhalation; Anesthesia; Anesthetics, Dissociative; Anesthetics, Inhalation; Anesthet

1989
In spontaneously hypertensive rats alterations in aortic wall properties precede development of hypertension.
    American journal of physiology. Heart and circulatory physiology, 2000, Volume: 278, Issue:4

    Topics: Adrenergic alpha-Agonists; Age Factors; Anesthetics, Dissociative; Animals; Aorta, Thoracic; Blood P

2000
[Possibilities of controlling the cardiovascular side effects of ketamine. Experimental and clinical study].
    Minerva anestesiologica, 1977, Volume: 43, Issue:8

    Topics: Adult; Anesthesia, Intravenous; Animals; Blood Pressure; Central Venous Pressure; Female; Heart Rate

1977
Anesthetic considerations in surgery for gastrointestinal disease.
    The Surgical clinics of North America, 1979, Volume: 59, Issue:5

    Topics: Aged; Anesthetics; Drug Interactions; Enflurane; Female; Gastrointestinal Diseases; Halothane; Human

1979
[Ionic changes produced by the use of ketamine].
    Revista espanola de anestesiologia y reanimacion, 1978, Volume: 25, Issue:1

    Topics: Anesthesia, General; Child; Child, Preschool; Electrolytes; Female; Halothane; Humans; Hypertension;

1978
Ketamine anaesthesia for medical procedures in children.
    Archives of disease in childhood, 1976, Volume: 51, Issue:1

    Topics: Adolescent; Anesthesia, Intravenous; Atropine; Child; Child, Preschool; Drug Combinations; Female; H

1976
[Cardiovascular effects of ketamine anesthesia in rats treated with enalapril and propranolol].
    Medicina, 1992, Volume: 52, Issue:3

    Topics: Anesthesia, General; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Enalapril; H

1992
[Clinical study on total intravenous anesthesia with droperidol, fentanyl and ketamine--9. Control of intraoperative hypertension with diltiazem].
    Masui. The Japanese journal of anesthesiology, 1991, Volume: 40, Issue:9

    Topics: Anesthesia, Intravenous; Diltiazem; Female; Fentanyl; Humans; Hypertension; Intraoperative Complicat

1991
[Clinical study on total intravenous anesthesia with droperidol, fentanyl and ketamine--4. Control of intraoperative hypertension with nicardipine].
    Masui. The Japanese journal of anesthesiology, 1991, Volume: 40, Issue:3

    Topics: Adolescent; Adult; Aged; Anesthesia, Intravenous; Droperidol; Female; Fentanyl; Humans; Hypertension

1991
[Anesthesia of a patient with hypertension, respiratory insufficiency and 2 occurrences of spontaneous pneumothorax for an arterial embolism of the lower extremity].
    Cahiers d'anesthesiologie, 1990, Volume: 38, Issue:5

    Topics: Aged; Anesthesia, Intravenous; Embolism; Humans; Hypertension; Ketamine; Leg; Male; Pneumothorax; Re

1990
Ventricular tachycardia and hypotension with amniotic fluid embolism during cesarean section.
    Anesthesia and analgesia, 1986, Volume: 65, Issue:5

    Topics: Adult; Anesthesia, Obstetrical; Blood Pressure; Bupivacaine; Cesarean Section; Diazepam; Electrocard

1986
Ketamine in neurosurgical procedures.
    Lancet (London, England), 1971, Jan-02, Volume: 1, Issue:7688

    Topics: Analgesics; Anesthesia, General; Child; Cyclohexanes; Humans; Hypertension; Injections, Intramuscula

1971
The effects of droperidol on modifying the hypertensive response to ketamine.
    Southern medical journal, 1974, Volume: 67, Issue:7

    Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Cardiac Output; Child; Dogs; Droperidol; Fema

1974
Selective indications for ketamine anaesthesia.
    Proceedings of the Royal Society of Medicine, 1971, Volume: 64, Issue:11

    Topics: Adult; Aged; Anesthesia, Dental; Anesthesia, General; Anesthesia, Spinal; Anesthetics; Burns; Cardia

1971
[On some cardiocirculatory effects of ketamine in chloralose-treated dogs].
    Comptes rendus des seances de la Societe de biologie et de ses filiales, 1971, Volume: 165, Issue:2

    Topics: Anesthetics; Animals; Chloralose; Cyclohexanes; Dogs; Epinephrine; Heart; Hemodynamics; Hypertension

1971
Study of ketamine as an obstetric anesthetic agent.
    American journal of obstetrics and gynecology, 1972, May-15, Volume: 113, Issue:2

    Topics: Adult; Anesthesia, Obstetrical; Anesthetics; Apgar Score; Bilirubin; Blood Pressure; Carbon Dioxide;

1972
Study of ketamine as an obstetric anesthetic agent.
    American journal of obstetrics and gynecology, 1972, May-15, Volume: 113, Issue:2

    Topics: Adult; Anesthesia, Obstetrical; Anesthetics; Apgar Score; Bilirubin; Blood Pressure; Carbon Dioxide;

1972
Study of ketamine as an obstetric anesthetic agent.
    American journal of obstetrics and gynecology, 1972, May-15, Volume: 113, Issue:2

    Topics: Adult; Anesthesia, Obstetrical; Anesthetics; Apgar Score; Bilirubin; Blood Pressure; Carbon Dioxide;

1972
Study of ketamine as an obstetric anesthetic agent.
    American journal of obstetrics and gynecology, 1972, May-15, Volume: 113, Issue:2

    Topics: Adult; Anesthesia, Obstetrical; Anesthetics; Apgar Score; Bilirubin; Blood Pressure; Carbon Dioxide;

1972
Ketamine. Indications, controversial special aspects, disadvantages.
    Acta anaesthesiologica Belgica, 1973, Volume: 24, Issue:2

    Topics: Adult; Anesthesia; Anesthesia, Obstetrical; Animals; Blood Pressure; Child; Dogs; Dose-Response Rela

1973
[Ketamine anesthesia by intravenous infusion. 1].
    Masui. The Japanese journal of anesthesiology, 1973, Volume: 22, Issue:1

    Topics: Adult; Anesthesia, Intravenous; Female; Humans; Hypertension; Ketamine; Middle Aged

1973
Serum dopamine beta-hydroxylase activity as an index of sympathetic activity.
    Journal of clinical pharmacology, 1974, Volume: 14, Issue:7

    Topics: Adult; Aged; Anesthesia; Animals; Blood Pressure; Catecholamines; Child; Child, Preschool; Circadian

1974
Clinical studies of induction agents. 38. Effect of premedicants and supplements on ketamine anaesthesia.
    British journal of anaesthesia, 1971, Volume: 43, Issue:6

    Topics: Adult; Analgesics; Anesthesia; Atropine; Benperidol; Blood Pressure; Cyclohexanes; Diazepam; Dreams;

1971
[Experience with Ketalar anesthesia].
    Nordisk medicin, 1971, Dec-02, Volume: 86, Issue:48

    Topics: Anesthetics; Blood Pressure; Child; Cyclohexanes; Cyclopropanes; Female; Halothane; Humans; Hyperten

1971
[Anesthesia with ketamines in surgery of the mouth, the jaw and the face].
    Deutsche zahnarztliche Zeitschrift, 1971, Volume: 26, Issue:10

    Topics: Adolescent; Adult; Anesthesia, Dental; Anesthesia, General; Anesthetics; Blood Pressure; Cardiac Out

1971
Problems with ketamine in adults.
    Anaesthesia, 1971, Volume: 26, Issue:1

    Topics: Adult; Anesthetics; Benperidol; Cyclohexanes; Delirium; Diazepam; Humans; Hypertension; Injections,

1971
Alarming reactions to ketamine in patients taking thyroid medication--treatment with propranolol.
    Anesthesiology, 1971, Volume: 35, Issue:2

    Topics: Adult; Analgesics; Anesthesia, Intravenous; Cyclohexanes; Drug Synergism; Female; Humans; Hypertensi

1971
Ketamine hydrochloride: a clinical investigation in 60 children.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1969, May-24, Volume: 43, Issue:21

    Topics: Analgesics; Anesthetics; Child; Child, Preschool; Chlorides; Cyclohexanes; Humans; Hypertension; Inf

1969