Drooling

Synonym
Drooling
Hypersalivation

Excerpt	Reference
"Drooling is a serious social handicap experienced by some neurologically impaired patients."	( Dreyfuss, P; Vogel, D; Walsh, N, 1991)
"Salivary drooling is a common and debilitating problem in cerebral palsy (CP)."	( Catto-Smith, AG; Heine, RG; Reddihough, DS, 1996)
"Hypersalivation is a common and frequently disabling side effect of atypical neuroleptics such as clozapine."	( Hagenah, J; Kahl, KG; Klein, C; Lencer, R; Trillenberg, P; Zapf, S, 2004)
"Hypersalivation is known as a frequent, disturbing, and socially stigmatizing side effect of therapy with the atypical antipsychotic clozapine."	( Fritze, J; Hiemke, C; Schneider, B; Weber, B; Weigmann, H, 2004)
"Hypersalivation is frequently observed in patients treated with clozapine."	( Hagenah, J; Kahl, KG; Klein, C; Kordon, A; Lencer, R; Trillenberg, P, 2005)
"Hypersalivation is a common, troublesome side effect of clozapine treatment."	( Epshtein, S; Kreinin, A; Sheinkman, A; Tell, E, 2005)
"The decrease in drooling is to a remarkable degree."	( Cedrone, N; Hurst, D, 2006)
"Drooling is a common dysfunction in children with cerebral palsy and may also affect neurologically unimpaired children."	( Hussain, SS; Kubba, H; Little, SA, 2009)
"Drooling is defined as an anterior salivary flow which can be insufficiently controlled due to dysphagia und orofacial motoric deficits."	( Ortfeld, S; Schönweiler, R; Steffen, A, 2011)
"Drooling is common in children with disordered oral-motor control."	( Banerjee, K; Buswell, CA; Fairhurst, C; O'Hare, A; Parr, JR; Pennington, L; Williams, J, 2012)
"Drooling is a common problem for children with cerebral palsy (CP)."	( Pennington, L; Smith, M; Walshe, M, 2012)
"Sialorrhea, or drooling, is seen in the pediatric population, especially in patients with cerebral palsy and other neurodevelopmental disabilities."	( Eiland, LS, 2012)
"Drooling is a distressing symptom for adults with neurological conditions and can be challenging for health professionals."	( Rowson, J; Squires, N; Wills, A, 2012)
"Drooling is distressing for patients and their families."	( Rowson, J; Squires, N; Wills, A, 2012)
"Drooling is a common problem for children with cerebral palsy (CP)."	( Pennington, L; Smith, M; Walshe, M, 2012)
"Drooling is the inability to retain saliva in the mouth and its progression to the digestive tract, being a common problem in pediatric patients with neurological disorders."	( Alonso-Curcó, X; Badosa-Pagès, J; Muchart, J; Paredes-Mercado, C; Póo, P; Táboas-Pereira, MA, 2015)
"Hypersalivation is a frequent, disturbing, and uncomfortable adverse effect of clozapine therapy that frequently leads to noncompliance."	( Bergman, J; Bersudsky, Y; Gaiduk, Y; Kreinin, A; Lerner, PP; Lerner, V; Miodownik, C; Mirkin, V; Yankovsky, Y, 2016)
"Drooling is a condition that affects patients with difficulties in swallowing, being common in patients with mental, neurological or dysphagic deficiency."	( Cacita, N; de Melo Peres, MPS; Franco, JB; Freua, KA; Ortega, KL, 2018)
"Sialorrhoea or drooling is a distressing and often socially isolating symptom seen in palliative care."	( Plunkett, C, 2021)
"Hypersalivation and drooling are commonly reported in clozapine-treated patients."	( Lambert, T; Mubaslat, O, 2020)
"Drooling is common in children with neurological disorders, but its management is very challenging, Scopolamine transdermal patch (STP) appears to be useful in controlling drooling, although it is not approved for this indication and there are limited clinical studies about its effectiveness."	( Abolfotouh, MA; Al Jeraisy, M; AlFuraih, M; AlKhalifah, B; AlOtaibi, H; AlSaif, R, 2020)
"Hypersalivation is a common, clozapine-related adverse drug reaction with a serious impact on quality of life."	( Haen, E; Hiemke, C; Kane, JM; Kuzin, M; Paulzen, M; Schoretsanitis, G, 2021)
"Drooling is characterized by an excessive pooling of saliva in the oral cavity."	( Nascimento, D, 2021)
"Drooling is not caused by a single factor; it is influenced and related to several clinical features."	( Nascimento, D, 2021)
"Drug-induced hypersalivation is a frequent drug adverse event of psychotropic drugs."	( Amad, A; Cuvelier, E; Décaudin, B; Fovet, T; Gressier, B; Simon, N, 2022)

Excerpt	Reference
"Hypersalivation has been reported as a side effect of atypical antipsychotics such as clozapine and olanzapine."	( Asada, T; Hori, T; Makabe, K; Nemoto, K, 2006)

Excerpt	Reference
"Primary outcome: Drooling Impact Scale (DIS) score at week-4."	( Cadwgan, J; Cole, M; Colver, AF; O'Hare, AE; Parr, JR; Pennington, L; Stocken, D; Todhunter, E; Tuffrey, C; Williams, J, 2018)
"The drooling impact scale was administered at time O and after 1 month."	( Aversa, M; Bella, GD; Campana, A; Castelli, E; De Ioris, MA; De Peppo, F; Geremia, C; Lettori, D; Lovardi, E; Scarselli, A; Scrocca, R; Staccioli, S, 2022)
"The mean Drooling Impact Scale at time 0 was 89 (range 81-100) and after 1 month 61(range 43-78); the difference was statistically significant (P < 0."	( Aversa, M; Bella, GD; Campana, A; Castelli, E; De Ioris, MA; De Peppo, F; Geremia, C; Lettori, D; Lovardi, E; Scarselli, A; Scrocca, R; Staccioli, S, 2022)

Excerpt	Reference
"Key search terms included clozapine, hypersalivation, sialorrhea, and treatment."	( Botts, SR; Davydov, L, 2000)
"Interventions to treat drooling should not only be evaluated using measurements of drooling, but the consequences on social interaction and self-esteem should also be assessed."	( Jongerius, PH; Rotteveel, JJ; van der Burg, JJ; van Hulst, K; van Limbeek, J, 2006)
"Clozapine-induced hypersalivation (CIH) is a significant side effect affecting about one-third of patients treated with clozapine."	( Remington, G; Shammi, C; Sockalingam, S, 2007)
"Clozapine-induced hypersalivation (CIH) occurs in up to 57% of treated patients and can be the source of considerable subjective distress."	( Remington, G; Shammi, C; Sockalingam, S, 2009)
"Previous treatments of drooling have little effect or are effective but with severe side effects."	( Bakke, M; Bardow, A; Karlsborg, M; Lykkeaa, J; Møller, E; Nissen, FH, 2011)
"This open, prospective study deals with treatment of drooling in 12 patients with amyotrophic lateral sclerosis and three with Parkinson's disease."	( Bakke, M; Bardow, A; Karlsborg, M; Lykkeaa, J; Møller, E; Nissen, FH, 2011)
"There was no clinically significant hypersalivation in children given ketamine sedation, with or without the coadministration of atropine."	( Ang, AS; Chew, SP; Chong, JH, 2013)
"In acute hypersalivation, the pharmacologic treatment with glycopyrrolate and scopolamine in various applications is useful but its value in long-term usage critical."	( Beutner, D; Guntinas-Lichius, O; Hakim, S; Jost, W; Kahl, KG; Laskawi, R; Lencer, R; Mall, V; Mehrhoff, FW; Meyners, T; Schönweiler, R; Schröder, S; Schröter-Morasch, H; Schuster, M; Steffen, A; Steinlechner, S; Winterhoff, J; Zenk, J, 2013)
"In the case of drug-induced hypersalivation, after failure of non-drug therapies and dosage optimization of the causative treatment, an anticholinergic drug can be initiated."	( Amad, A; Cuvelier, E; Décaudin, B; Fovet, T; Gressier, B; Simon, N, 2022)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	81 (19.01)	23.3326
1990's	68 (15.96)	12.5806
2000's	104 (24.41)	18.1394
2010's	132 (30.99)	28.8240
2020's	41 (9.62)	9.53

Drug	Relationship Strength	Studies	Trials
ammonium hydroxide	low	3	0
bromide	low	2	0
carbamates	low	1	0
carnitine	low	1	0
citric acid, anhydrous	low	1	0
chlorine	low	3	0
bupropion	low	1	0
diacetyl	low	1	0
hydrogen carbonate	low	1	0
iodine	low	1	0
pipecolic acid	low	1	0
orotic acid	low	1	0
parathion	low	1	0
propylene glycol	low	1	0
pyridoxine	low	1	0
thiamine	low	1	0
uric acid	low	2	0
urea	low	1	0
adiphenine	low	1	0
theophylline	low	1	0
dan 2163	medium	7	2
amitriptyline	medium	12	1
amobarbital	low	1	0
antazoline	low	1	0
astemizole	low	1	0
bethanechol	low	2	0
biperiden	medium	3	1
bretylium	low	1	0
carbamazepine	low	1	0
chloroquine	low	1	0
chlorpyrifos	low	1	0
cisapride	medium	1	1
citalopram	low	1	0
clonidine	medium	4	1
cyclopentolate	low	1	0
desipramine	low	1	0
diazepam	low	1	0
dibucaine	low	1	0
diphenhydramine	low	2	0
distigmine	medium	4	1
valproic acid	low	3	0
domperidone	low	1	0
donepezil	medium	2	1
doxepin	low	1	0
endosulfan	low	1	0
fenvalerate	low	1	0
fluphenazine	low	1	0
flurbiprofen	low	1	0
gentamicin	low	1	0
guaifenesin	low	2	0
guanethidine	low	2	0
guanfacine	low	1	0
haloperidol	medium	1	1
imipramine	low	1	0
isoproterenol	low	2	0
ketamine	medium	7	2
lorazepam	low	1	0
meclizine	low	1	0
methantheline	low	3	0
metoclopramide	medium	3	1
mianserin	low	1	0
midazolam	low	2	0
moclobemide	medium	1	1
modafinil	low	1	0
deet	low	1	0
apnea	low	2	0
nialamide	low	1	0
nitrazepam	low	1	0
oxotremorine	low	1	0
oxybutynin	medium	4	1
phenobarbital	low	1	0
phenylbutazone	low	1	0
piracetam	low	2	0
pirenzepine	medium	5	2
piribedil	low	2	0
procainamide	low	1	0
prochlorperazine	low	2	0
propantheline	low	2	0
propofol	low	3	0
propranolol	low	1	0
riluzole	low	1	0
risperidone	medium	7	1
sevoflurane	medium	1	1
succinylcholine	low	1	0
sulpiride	medium	9	2
tranexamic acid	low	1	0
trihexyphenidyl	medium	10	2
tropicamide	medium	2	1
reserpine	low	1	0
carbachol	low	2	0
penicillamine	low	1	0
trichlorfon	medium	1	1
prednisone	low	1	0
dehydroepiandrosterone	low	1	0
pilocarpine	medium	7	1
lysine	low	1	0
apomorphine	low	1	0
carbostyril	low	1	0
levodopa	low	8	0
tyrosine	low	4	0
methacholine chloride	low	1	0
carbaryl	low	1	0
cytarabine	low	1	0
asparagine	low	1	0
histidine	low	1	0
tryptophan	low	2	0
arginine	low	2	0
methylprednisolone	low	1	0
sarin	low	1	0
thiophenes	low	1	0
tecnazene	low	1	0
framycetin	low	1	0
galantamine	low	1	0
dimenhydrinate	low	1	0
lithium carbonate	low	3	0
glycopyrrolate	medium	48	12
acetylcysteine	low	1	0
4-methylimidazole	low	1	0
potassium hydroxide	low	1	0
metylperon	low	1	0
paraquat	low	1	0
streptomycin	low	1	0
limonene	low	1	0
mercury	low	1	0
silver	low	3	0
technetium	low	4	0
camptothecin	low	1	0
bromine	low	1	0
barium sulfate	low	1	0
fluorine	low	1	0
technetium 99m	low	1	0
phytanic acid	low	1	0
fluorides	low	1	0
lofexidine	low	1	0
amoxicillin	low	1	0
substance p	low	2	0
epirubicin	low	1	0
dihydroalprenolol	low	1	0
propiconazole	low	1	0
captopril	low	1	0
fomesafen	low	16	0
swainsonine	low	2	0
n 0437, (-)-isomer	low	1	0
aripiprazole	low	3	0
irinotecan	low	1	0
fluorodeoxyglucose f18	low	1	0
sertraline	low	1	0
artemisinin	low	1	0
rivastigmine	low	2	0
slaframine	low	4	0
mebeverine	low	1	0
pristanic acid	low	1	0
methotrexate	low	1	0
atropine	medium	35	6
dibenzheptropine	low	1	0
cp 424391	medium	1	1
solifenacin succinate	low	1	0
dihydropyridines	low	1	0
anatoxin a	low	1	0
inositol 3-phosphate	medium	32	1
rocuronium	low	1	0
arginine vasopressin	low	2	0
sesquiterpenes	low	1	0
benztropine	medium	8	3
ranitidine	medium	2	1
pica	low	1	0
lithium	low	2	0
phosphamidon	low	1	0
raclopride	low	1	0
ethamolin	low	1	0
phenylephrine hydrochloride	low	1	0
hydromorphone	low	1	0
levetiracetam	low	1	0
ciguatoxins	low	1	0
fluvoxamine	low	1	0
sulfur	low	1	0
monocrotophos	low	1	0
cysteine	low	1	0
phosphorus	low	2	0
cafedrine, theodrenaline drug combination	low	1	0
selenium	low	1	0
diacetylmonoxime	low	1	0
butylscopolammonium bromide	low	1	0
chlorhexidine	low	4	0
milameline	low	1	0
paliperidone palmitate	low	1	0
alpha-synuclein	low	1	0
dextrothyroxine	low	1	0
scopolamine hydrobromide	medium	46	12
pituitrin	low	2	0
jaw	low	3	0
tannins	low	1	0
sodium tetradecyl sulfate	low	1	0
sodium pertechnetate tc 99m	low	1	0
piperidines	medium	4	3
vasoactive intestinal peptide	low	2	0
oxytetracycline, anhydrous	low	1	0
pyrethrins	low	2	0
cyclosporine	low	1	0
exudates	medium	1	1
clozapine	medium	112	22
olanzapine	medium	5	1
pralidoxime	low	1	0
norclozapine	medium	3	1

Protein Targets (1,326)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
RAR-related orphan receptor gamma	38	0	0	38
AR protein	67	0	0	67
aldehyde dehydrogenase 1 family, member A1	32	0	0	32
geminin	53	0	0	53
Peptidyl-prolyl cis-trans isomerase FKBP5	0	0	1	1
Glutaminyl-peptide cyclotransferase	0	2	0	2
thyroid stimulating hormone receptor	30	0	0	30
cytochrome P450 2D6 isoform 1	32	0	0	32
lethal factor (plasmid)	18	0	0	18
lamin isoform A-delta10	55	0	0	55
Bile salt export pump	0	81	0	81
Major prion protein	0	0	7	7
Trypanothione reductase	0	8	0	8
Chain A, JmjC domain-containing histone demethylation protein 3A	12	0	0	12
Chain A, 2-oxoglutarate Oxygenase	17	0	0	17
Chain A, ATP-DEPENDENT DNA HELICASE Q1	4	0	0	4
acetylcholinesterase	33	0	0	33
dopamine D1 receptor	5	0	0	5
15-lipoxygenase, partial	11	0	0	11
pregnane X receptor	8	0	0	8
phosphopantetheinyl transferase	28	0	0	28
USP1 protein, partial	36	0	0	36
NFKB1 protein, partial	17	0	0	17
Microtubule-associated protein tau	26	0	0	26
Thrombopoietin	11	0	0	11
regulator of G-protein signaling 4	27	0	0	27
glucocorticoid receptor [Homo sapiens]	46	0	0	46
retinoic acid nuclear receptor alpha variant 1	43	0	0	43
retinoid X nuclear receptor alpha	31	0	0	31
farnesoid X nuclear receptor	25	0	0	25
estrogen nuclear receptor alpha	63	0	0	63
vitamin D (1,25- dihydroxyvitamin D3) receptor	27	0	0	27
arylsulfatase A	28	0	0	28
euchromatic histone-lysine N-methyltransferase 2	69	0	0	69
Bloom syndrome protein isoform 1	21	0	0	21
D(1A) dopamine receptor	30	0	0	30
thyroid hormone receptor beta isoform a	15	0	0	15
thyroid hormone receptor beta isoform 2	42	0	0	42
heat shock protein beta-1	14	0	0	14
flap endonuclease 1	20	0	0	20
peripheral myelin protein 22	40	0	0	40
survival motor neuron protein isoform d	15	0	0	15
muscarinic acetylcholine receptor M1	28	0	0	28
Histone deacetylase 3	0	4	0	4
Solute carrier family 22 member 6	0	1	0	1
Histone deacetylase 4	0	4	0	4
Guanine nucleotide-binding protein G	5	0	0	5
Histone deacetylase 1	0	4	0	4
Histone deacetylase 7	0	4	0	4
Histone deacetylase 2	0	4	0	4
Polyamine deacetylase HDAC10	0	4	0	4
Histone deacetylase 11	0	4	0	4
Ataxin-2	34	0	0	34
Histone deacetylase 8	0	4	0	4
Histone deacetylase 6	0	4	0	4
Histone deacetylase 9	0	4	0	4
Histone deacetylase 5	0	4	0	4
ATP-dependent phosphofructokinase	32	0	0	32
Histamine H1 receptor	0	40	3	46
Chain A, HADH2 protein	21	0	0	21
Chain B, HADH2 protein	21	0	0	21
thioredoxin reductase	42	0	0	42
GLS protein	35	0	0	35
cytochrome P450 family 3 subfamily A polypeptide 4	47	0	0	47
cytochrome P450 2D6	44	0	0	44
chromobox protein homolog 1	46	0	0	46
atrial natriuretic peptide receptor 2 precursor	10	0	0	10
serine/threonine-protein kinase mTOR isoform 1	14	0	0	14
nuclear factor erythroid 2-related factor 2 isoform 1	44	0	0	44
Solute carrier family 22 member 1	0	23	0	28
Polyunsaturated fatty acid lipoxygenase ALOX15B	15	0	0	15
ATP-binding cassette sub-family C member 3	0	50	0	50
Multidrug resistance-associated protein 4	0	50	0	51
Voltage-dependent L-type calcium channel subunit alpha-1F	0	11	0	11
5-hydroxytryptamine receptor 4	0	50	1	51
Albumin	0	0	8	8
High affinity nerve growth factor receptor	0	1	2	3
Aldo-keto reductase family 1 member B1	0	39	0	39
Muscarinic acetylcholine receptor M2	0	54	10	69
Muscarinic acetylcholine receptor M4	0	53	7	63
Muscarinic acetylcholine receptor M1	0	20	2	27
Muscarinic acetylcholine receptor M3	0	18	2	24
Muscarinic acetylcholine receptor M4	0	17	1	22
5-hydroxytryptamine receptor 2C	0	21	1	23
Muscarinic acetylcholine receptor M5	0	19	1	24
Muscarinic acetylcholine receptor M5	0	49	6	58
Alpha-2A adrenergic receptor	0	49	6	57
Muscarinic acetylcholine receptor M2	0	20	2	27
Muscarinic acetylcholine receptor M1	0	55	13	74
Angiotensin-converting enzyme	0	28	0	29
D(2) dopamine receptor	0	45	7	61
5-hydroxytryptamine receptor 2A	0	21	1	22
Alpha-2B adrenergic receptor	0	44	4	50
Alpha-2C adrenergic receptor	0	46	6	54
5-hydroxytryptamine receptor 1A	0	40	3	44
Muscarinic acetylcholine receptor M3	0	52	8	63
D(1A) dopamine receptor	0	31	4	40
D(1B) dopamine receptor	0	9	0	13
UDP-glucuronosyltransferase 1A4	0	2	0	9
Sodium-dependent noradrenaline transporter	0	49	3	52
Histamine H2 receptor	0	22	0	22
Alpha-1D adrenergic receptor	0	41	4	46
5-hydroxytryptamine receptor 2A	0	52	1	56
5-hydroxytryptamine receptor 2C	0	53	2	55
5-hydroxytryptamine receptor 1B	0	31	1	32
5-hydroxytryptamine receptor 1D	0	13	1	14
5-hydroxytryptamine receptor 1F	0	13	1	14
5-hydroxytryptamine receptor 2B	0	19	2	21
5-hydroxytryptamine receptor 6	0	6	1	7
Histamine H1 receptor	0	9	0	9
Sodium-dependent serotonin transporter	0	48	3	51
5-hydroxytryptamine receptor 7	0	13	1	14
5-hydroxytryptamine receptor 5A	0	6	1	7
5-hydroxytryptamine receptor 5B	0	6	1	7
D(3) dopamine receptor	0	44	4	56
Sodium channel protein type 1 subunit alpha	0	5	0	5
Sodium channel protein type 4 subunit alpha	0	7	0	8
UDP-glucuronosyltransferase 1A3	0	0	0	3
5-hydroxytryptamine receptor 3A	0	13	1	14
5-hydroxytryptamine receptor 2B	0	54	2	56
Alpha-1A adrenergic receptor	0	31	6	37
Histamine H2 receptor	24	5	1	37
D(1A) dopamine receptor	13	1	0	14
5-hydroxytryptamine receptor 6	0	28	1	32
5-hydroxytryptamine receptor 7	0	14	0	14
Voltage-dependent N-type calcium channel subunit alpha-1B	0	4	0	4
Sodium channel protein type 7 subunit alpha	0	4	0	4
Voltage-dependent L-type calcium channel subunit alpha-1D	0	11	0	11
Sodium-dependent dopamine transporter	0	30	2	32
Potassium voltage-gated channel subfamily H member 2	0	47	1	48
Voltage-dependent L-type calcium channel subunit alpha-1S	0	11	0	11
Voltage-dependent L-type calcium channel subunit alpha-1C	0	12	0	12
Sodium channel protein type 5 subunit alpha	0	11	0	11
Sodium channel protein type 9 subunit alpha	0	7	0	7
Sigma non-opioid intracellular receptor 1	0	6	2	8
5-hydroxytryptamine receptor 4	0	7	2	11
Nuclear receptor subfamily 3 group C member 3	0	25	0	25
Canalicular multispecific organic anion transporter 1	0	50	0	50
Sodium channel protein type 2 subunit alpha	0	5	0	5
Sigma non-opioid intracellular receptor 1	0	39	0	39
5-hydroxytryptamine receptor 3B	0	13	1	14
Sodium channel protein type 3 subunit alpha	0	6	0	6
Sodium channel protein type 11 subunit alpha	0	4	0	4
Sodium channel protein type 8 subunit alpha	0	4	0	4
Histamine H3 receptor	0	8	0	8
Sodium channel protein type 10 subunit alpha	0	4	0	4
TDP1 protein	54	0	0	54
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	22	0	0	22
Chain A, Beta-lactamase	14	0	0	14
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
apical membrane antigen 1, AMA1	5	0	0	5
Beta-lactamase	0	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	11	0	0	11
DNA polymerase eta isoform 1	5	0	0	5
DNA polymerase iota isoform a (long)	22	0	0	22
urokinase-type plasminogen activator precursor	7	0	0	7
plasminogen precursor	7	0	0	7
urokinase plasminogen activator surface receptor precursor	7	0	0	7
DNA polymerase kappa isoform 1	10	0	0	10
Bile salt export pump	0	13	0	13
Beta-lactamase SHV-1	0	0	0	1
Beta-lactamase SHV-1	0	0	0	1
Cytochrome P450 2C9	0	15	0	16
Beta-lactamase	0	0	0	1
Kappa-type opioid receptor	0	2	0	3
Solute carrier family 15 member 1	0	2	0	2
Solute carrier family 15 member 1	0	2	0	2
Cytochrome P450 2J2	0	11	0	13
B2 metallo-beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Acetylcholine receptor subunit alpha	0	1	0	1
Acetylcholine receptor subunit beta	0	1	0	1
Acetylcholine receptor subunit gamma	0	1	0	1
Acetylcholine receptor subunit delta	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-3	0	4	1	5
Neuronal acetylcholine receptor subunit alpha-4	6	6	1	13
Neuronal acetylcholine receptor subunit alpha-2	0	3	1	4
Neuronal acetylcholine receptor subunit beta-2	6	6	1	13
Neuronal acetylcholine receptor subunit beta-3	0	3	1	4
Neuronal acetylcholine receptor subunit beta-4	0	4	1	5
Neuronal acetylcholine receptor subunit beta-2	0	2	0	3
Neuronal acetylcholine receptor subunit alpha-5	0	3	1	4
Neuronal acetylcholine receptor subunit alpha-6	0	3	1	4
Neuronal acetylcholine receptor subunit alpha-9	0	3	1	4
Neuronal acetylcholine receptor subunit alpha-4	0	2	0	3
Neuronal acetylcholine receptor subunit alpha-7	0	5	1	6
Neuronal acetylcholine receptor subunit alpha-10	0	3	1	4
histone-lysine N-methyltransferase 2A isoform 2 precursor	6	0	0	6
Histamine H1 receptor	0	5	1	8
Inositol monophosphatase 1	18	0	0	18
ATAD5 protein, partial	21	0	0	21
estrogen-related nuclear receptor alpha	55	0	0	55
neuropeptide S receptor isoform A	8	0	0	8
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	19	0	0	19
Chain A, Putative fructose-1,6-bisphosphate aldolase	7	0	0	7
Luciferase	17	0	0	17
hypoxia-inducible factor 1 alpha subunit	17	0	0	17
GLI family zinc finger 3	47	0	0	47
estrogen receptor 2 (ER beta)	28	0	0	28
nuclear receptor subfamily 1, group I, member 3	41	0	0	41
progesterone receptor	35	0	0	35
peroxisome proliferator-activated receptor delta	24	0	0	24
peroxisome proliferator activated receptor gamma	30	0	0	30
aryl hydrocarbon receptor	20	0	0	20
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	25	0	0	25
thyroid stimulating hormone receptor	27	0	0	27
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	20	0	0	20
v-jun sarcoma virus 17 oncogene homolog (avian)	34	0	0	34
Histone H2A.x	20	0	0	20
cellular tumor antigen p53 isoform a	10	0	0	10
cytochrome P450 2C19 precursor	18	0	0	18
cytochrome P450 2C9 precursor	13	0	0	13
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	10	0	0	10
vitamin D3 receptor isoform VDRA	26	0	0	26
potassium voltage-gated channel subfamily H member 2 isoform d	34	0	0	34
mitogen-activated protein kinase 1	22	0	0	22
nuclear receptor ROR-gamma isoform 1	13	0	0	13
cytochrome P450 3A4 isoform 1	28	0	0	28
Gamma-aminobutyric acid receptor subunit pi	28	7	3	38
Voltage-dependent calcium channel gamma-2 subunit	23	0	0	23
Cellular tumor antigen p53	42	0	0	42
Integrin beta-3	9	0	0	9
Integrin alpha-IIb	9	0	0	9
5-hydroxytryptamine receptor 1A	0	17	6	23
Tryptophan 5-hydroxylase 1	0	4	0	4
Gamma-aminobutyric acid receptor subunit beta-1	28	7	3	38
Alpha-1B adrenergic receptor	0	29	5	34
Gamma-aminobutyric acid receptor subunit delta	28	7	3	38
Gamma-aminobutyric acid receptor subunit gamma-2	28	7	3	38
D	0	20	0	21
D(3) dopamine receptor	0	19	0	19
Alpha-2B adrenergic receptor	0	22	5	27
Glutamate receptor 2	23	0	0	23
Gamma-aminobutyric acid receptor subunit alpha-5	28	7	3	38
Gamma-aminobutyric acid receptor subunit alpha-3	28	7	3	38
D(2) dopamine receptor	0	9	0	9
D(4) dopamine receptor	0	24	2	32
Alpha-2C adrenergic receptor	0	22	5	27
Alpha-2A adrenergic receptor	0	22	5	27
Gamma-aminobutyric acid receptor subunit gamma-1	28	7	3	38
Gamma-aminobutyric acid receptor subunit alpha-2	28	7	3	38
Alpha-1D adrenergic receptor	0	24	5	30
D(1B) dopamine receptor	0	13	0	13
Gamma-aminobutyric acid receptor subunit alpha-4	28	7	3	38
Gamma-aminobutyric acid receptor subunit gamma-3	28	7	3	38
Gamma-aminobutyric acid receptor subunit alpha-6	28	7	3	38
D(4) dopamine receptor	0	15	1	16
Spike glycoprotein	32	4	6	42
D(2) dopamine receptor	0	28	3	33
Gamma-aminobutyric acid receptor subunit alpha-1	28	7	3	38
Gamma-aminobutyric acid receptor subunit beta-3	28	7	3	38
Gamma-aminobutyric acid receptor subunit beta-2	28	7	3	38
E3 ubiquitin-protein ligase Mdm2	0	2	0	2
D	0	1	0	1
GABA theta subunit	28	7	3	38
D	0	7	0	7
ATPase family AAA domain-containing protein 5	13	0	0	13
Gamma-aminobutyric acid receptor subunit epsilon	28	7	3	38
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
alpha-galactosidase	4	0	0	4
Cytochrome P450 3A4	0	18	0	22
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	1	0	2
Nitric oxide synthase, brain	0	0	0	2
Nitric oxide synthase, inducible	0	0	0	1
Nitric oxide synthase, inducible	0	0	1	4
Cationic amino acid transporter 3	0	2	0	2
Translocator protein	0	2	2	5
Vasopressin V2 receptor	0	2	1	4
Oxytocin receptor	0	1	1	2
Vasopressin V1a receptor	0	0	3	3
Vasopressin V1a receptor	0	2	2	4
Vasopressin V1b receptor	0	1	1	2
Vasopressin V2 receptor	0	0	1	1
Vasopressin V1b receptor	0	1	1	3
Translocator protein	0	1	0	2
Oxytocin receptor	0	1	1	2
Vasopressin V2 receptor	0	1	1	2
5-hydroxytryptamine receptor 3E	0	5	1	6
SMAD family member 2	13	0	0	13
Fumarate hydratase	15	0	0	15
PPM1D protein	10	0	0	10
SMAD family member 3	13	0	0	13
EWS/FLI fusion protein	27	0	0	27
pregnane X nuclear receptor	43	0	0	43
G	20	0	0	20
polyprotein	15	0	0	15
67.9K protein	12	0	0	12
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	5	0	0	5
lysosomal alpha-glucosidase preproprotein	9	0	0	9
mu-type opioid receptor isoform MOR-1	0	0	3	3
nuclear factor erythroid 2-related factor 2 isoform 2	12	0	0	12
transcriptional regulator ERG isoform 3	7	0	0	7
histone acetyltransferase KAT2A isoform 1	19	0	0	19
5-hydroxytryptamine receptor 2A	0	0	3	3
Solute carrier family 22 member 2	0	8	0	9
5-hydroxytryptamine receptor 3A	0	2	1	3
5-hydroxytryptamine receptor 3B	0	5	1	6
Interferon beta	30	0	0	30
HLA class I histocompatibility antigen, B alpha chain	20	0	0	20
ATP-dependent translocase ABCB1	0	13	0	19
5-hydroxytryptamine receptor 7	0	13	1	14
Alpha-1A adrenergic receptor	0	14	6	21
Alpha-1B adrenergic receptor	0	10	5	16
5-hydroxytryptamine receptor 3A	0	5	1	6
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	4	0	4
5-hydroxytryptamine receptor 3D	0	5	1	6
Multidrug and toxin extrusion protein 2	0	6	0	6
5-hydroxytryptamine receptor 3C	0	5	1	6
Inositol hexakisphosphate kinase 1	20	0	0	20
Multidrug and toxin extrusion protein 1	0	9	0	9
cytochrome P450 2C9, partial	20	0	0	20
Chain A, Ferritin light chain	9	0	0	9
nonstructural protein 1	12	0	0	12
TAR DNA-binding protein 43	11	0	0	11
Dihydroorotate dehydrogenase	0	1	0	1
Carbonic anhydrase 1	0	11	0	18
Carbonic anhydrase 2	0	12	2	21
Neutral amino acid transporter A	0	1	0	1
Neutral amino acid transporter B(0)	0	1	0	1
Carbonic anhydrase-like protein, putative	0	0	0	5
Amino acid transporter	0	1	0	1
glp-1 receptor, partial	16	0	0	16
Smad3	7	0	0	7
caspase 7, apoptosis-related cysteine protease	12	0	0	12
glucocerebrosidase	10	0	0	10
bromodomain adjacent to zinc finger domain 2B	10	0	0	10
caspase-3	12	0	0	12
IDH1	18	0	0	18
activating transcription factor 6	16	0	0	16
thyrotropin-releasing hormone receptor	4	0	0	4
Caspase-7	5	0	0	5
Spike glycoprotein	0	4	6	10
Replicase polyprotein 1ab	0	4	6	10
caspase-3	5	0	0	5
huntingtin isoform 2	7	0	0	7
ubiquitin-conjugating enzyme E2 N	0	2	0	2
ubiquitin carboxyl-terminal hydrolase 2 isoform a	9	0	0	9
Transmembrane protease serine 2	0	4	6	10
Polycomb protein EED	0	2	0	2
Epidermal growth factor receptor	0	4	0	4
HLA class I histocompatibility antigen, A alpha chain	0	0	2	2
Receptor tyrosine-protein kinase erbB-2	0	3	0	3
Tyrosine-protein kinase Lck	0	2	0	2
Tyrosine-protein kinase Fyn	0	6	0	6
ATP-dependent translocase ABCB1	0	3	0	3
Procathepsin L	0	4	6	10
Beta-1 adrenergic receptor	0	7	3	10
Replicase polyprotein 1a	0	4	6	10
Replicase polyprotein 1ab	0	4	6	10
Replicase polyprotein 1ab	0	5	6	11
Adenosine receptor A3	0	6	1	7
Replicase polyprotein 1ab	0	5	6	11
Beta-3 adrenergic receptor	0	8	3	11
ATP-dependent translocase ABCB1	0	3	0	3
Substance-K receptor	0	8	0	8
Glycine receptor subunit alpha-1	0	0	2	2
Substance-P receptor	0	4	1	5
Somatostatin receptor type 2	0	2	0	2
Somatostatin receptor type 4	0	2	0	2
Melanocortin receptor 4	0	4	0	4
Somatostatin receptor type 3	0	2	0	2
Melanocortin receptor 5	0	8	0	8
Somatostatin receptor type 5	0	2	0	2
Mu-type opioid receptor	0	14	3	17
Delta-type opioid receptor	0	8	1	9
Kappa-type opioid receptor	0	10	2	12
Melanocortin receptor 3	0	4	0	4
Disintegrin and metalloproteinase domain-containing protein 17	7	0	0	7
Sigma intracellular receptor 2	0	4	0	4
Angiotensin-converting enzyme 2	0	5	6	11
Histamine H4 receptor	0	4	1	5
Heparanase	0	0	2	2
cystic fibrosis transmembrane conductance regulator	0	1	0	1
DNA polymerase beta	7	0	0	7
short transient receptor potential channel 6 isoform 1	0	0	2	2
Muscarinic acetylcholine receptor M1	0	2	3	6
Muscarinic acetylcholine receptor M4	0	2	0	2
Reverse transcriptase/RNaseH	0	0	0	1
Muscarinic acetylcholine receptor	0	5	2	7
endonuclease IV	7	0	0	7
peripheral myelin protein 22 isoform 1	13	0	0	13
lethal(3)malignant brain tumor-like protein 1 isoform I	3	0	0	3
M-phase phosphoprotein 8	18	0	0	18
Coagulation factor VII	0	1	0	1
Poly [ADP-ribose] polymerase 1	0	1	0	1
Tissue factor	0	2	0	2
Nicotinamide N-methyltransferase	0	1	0	1
Poly(ADP-ribose) glycohydrolase	0	1	0	1
Sodium-dependent dopamine transporter	0	16	1	17
Sodium-dependent serotonin transporter	0	14	1	15
Chain A, Cruzipain	6	0	0	6
caspase-1 isoform alpha precursor	3	0	0	3
Caspase-7	3	0	0	3
Solute carrier organic anion transporter family member 1B3	0	2	0	4
Solute carrier organic anion transporter family member 1B1	0	2	0	3
Carbonic anhydrase 4	0	5	0	9
Carbonic anhydrase	0	5	0	9
Carbonic anhydrase 15	0	5	0	9
Acetylcholine receptor subunit alpha	0	1	0	1
Acetylcholine receptor subunit gamma	0	1	0	1
Integrin alpha-5	0	1	0	1
Acetylcholine receptor subunit beta	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	4	0	9
UDP-glucuronosyltransferase 1-6	0	2	0	3
Cytochrome P450 2B6	0	0	1	3
UDP-glucuronosyltransferase 1A1	0	3	0	3
Neuronal acetylcholine receptor subunit beta-4	0	1	0	2
Neuronal acetylcholine receptor subunit alpha-3	0	1	0	1
Cytochrome P450 2C19	0	7	0	9
UDP-glucuronosyltransferase 2B10	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Acetylcholine receptor subunit delta	0	1	0	1
DNA topoisomerase	0	1	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	17	0	0	17
putative alpha-glucosidase	1	0	0	1
hemoglobin subunit beta	2	0	0	2
ras-related protein Rab-9A	6	0	0	6
eukaryotic translation initiation factor 2-alpha kinase 3 isoform 1 precursor	0	0	1	1
muscleblind-like protein 1 isoform 1	7	0	0	7
relaxin receptor 1 isoform 1	1	0	0	1
Telomerase reverse transcriptase	0	1	0	1
Serine/threonine-protein kinase Chk1	0	0	1	1
Type-2 restriction enzyme ScaI	0	1	0	1
Deoxyribonuclease-2-alpha	0	1	0	1
Tyrosyl-DNA phosphodiesterase 2	0	1	0	1
Deoxyribonuclease-1	0	1	0	1
Type-2 restriction enzyme PstI	0	1	0	1
Type-2 restriction enzyme EcoRI	0	1	0	1
Prothrombin	0	1	0	2
DNA ligase	0	2	0	2
Heterogeneous nuclear ribonucleoprotein A1	0	0	1	1
DNA topoisomerase 1	0	2	1	8
DNA topoisomerase 2-alpha	0	1	0	1
Type-2 restriction enzyme BamHI	0	1	0	1
Somatostatin receptor type 1	0	1	0	1
Type-2 restriction enzyme HindIII	0	1	0	1
Ribonuclease pancreatic	0	1	0	1
DNA topoisomerase 2-beta	0	0	0	1
DNA topoisomerase 1	0	1	0	2
DNA topoisomerase 1	0	1	0	1
Integrase	0	1	0	1
DNA topoisomerase type IB small subunit	0	0	1	1
Tyrosyl-DNA phosphodiesterase 1	0	2	0	2
Chain A, angiotensin converting enzyme	0	1	0	1
Chain A, angiotensin converting enzyme	0	1	0	1
thioredoxin glutathione reductase	6	0	0	6
Metallo-beta-lactamase type 2	0	1	1	2
transient receptor potential cation channel subfamily V member 1	3	0	0	3
Renin	0	2	0	2
Neprilysin	0	1	0	1
Neprilysin	0	1	0	1
Leukotriene A-4 hydrolase	0	2	1	3
EEF1AKMT4-ECE2 readthrough transcript protein	0	1	0	1
Angiotensin-converting enzyme	0	2	1	3
Leukotriene A-4 hydrolase	0	1	0	1
Thymidine phosphorylase	0	0	1	1
Prostaglandin G/H synthase 1	0	3	0	3
Prostaglandin G/H synthase 2	0	4	0	4
Endothelin-converting enzyme 1	0	1	0	1
Succinyl-diaminopimelate desuccinylase	0	3	0	3
Angiotensin-converting enzyme	0	3	0	3
Beta-lactamase TEM	0	1	0	1
Mu-type opioid receptor	0	2	1	3
Beta-lactamase	0	2	0	3
Beta-lactamase	0	2	0	2
Beta-lactamase class B VIM-2	0	1	1	2
GALC protein	8	0	0	8
Delta-type opioid receptor	0	4	0	5
Muscarinic acetylcholine receptor M3	0	1	1	4
Muscarinic acetylcholine receptor M2	0	1	0	4
Vpr	2	0	0	2
Sodium channel protein type 1 subunit alpha	0	2	0	2
Sodium channel protein type 2 subunit alpha	0	3	0	3
Sodium channel protein type 3 subunit alpha	0	2	0	2
Frizzled-8	0	0	1	1
P2X purinoceptor 4	0	1	0	1
kallikrein-5 preproprotein	0	1	0	1
Fatty-acid amide hydrolase 1	0	2	0	2
Acetylcholinesterase	0	7	1	8
Chain A, serum paraoxonase	0	1	0	1
Carbonic anhydrase 12	0	2	0	6
Carbonic anhydrase 3	0	2	0	6
Neutrophil cytosol factor 1	0	1	0	1
Carbonic anhydrase 6	0	3	0	7
Carbonic anhydrase 5A, mitochondrial	0	2	0	6
Carbonic anhydrase 7	0	2	0	6
Carbonic anhydrase 9	0	3	1	9
Carbonic anhydrase 13	0	1	0	2
Poly [ADP-ribose] polymerase tankyrase-2	0	1	0	1
Carbonic anhydrase 14	0	1	0	5
Carbonic anhydrase 5B, mitochondrial	0	2	0	6
Solute carrier family 22 member 5	0	0	0	1
Solute carrier family 22 member 5	0	0	0	1
Solute carrier family 22 member 16	0	0	0	1
Solute carrier family 22 member 21	0	0	0	1
Solute carrier family 22 member 5	0	0	0	1
Chain A, BCL-2-RELATED PROTEIN A1	0	0	1	1
acid sphingomyelinase	2	0	0	2
interleukin 8	3	0	0	3
PAX8	0	0	0	1
PINK1	2	0	0	2
Parkin	4	0	0	4
heat shock protein 90	0	0	1	1
calcineurin A1, putative	0	0	1	1
hepatocyte nuclear factor 4-alpha isoform 2	0	2	0	2
perilipin-5	0	2	0	2
perilipin-1	0	2	0	2
importin subunit beta-1 isoform 1	5	0	0	5
nuclear factor NF-kappa-B p105 subunit isoform 1	3	0	0	3
protein AF-9 isoform a	0	0	0	1
snurportin-1	5	0	0	5
melanocortin receptor 4	0	1	0	1
CAAX prenyl protease	0	0	0	1
bcl-2-related protein A1	0	1	0	1
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	2	0	2
glycogen synthase kinase-3 alpha	0	0	0	1
hexokinase HKDC1	0	1	0	1
DNA repair protein RAD52 homolog isoform a	0	0	0	1
bcl-2-like protein 11 isoform 1	0	0	1	1
Synaptojanin-2	0	1	0	1
Synaptojanin-1	0	1	0	1
Solute carrier family 22 member 3	0	7	0	8
Glutathione reductase, mitochondrial	0	3	0	4
72 kDa type IV collagenase	0	1	0	1
Matrix metalloproteinase-9	0	1	0	1
Alpha-synuclein	6	0	0	6
Nuclear receptor ROR-gamma	9	0	0	9
Peroxisomal N(1)-acetyl-spermine/spermidine oxidase	0	1	0	1
Rap guanine nucleotide exchange factor 4	4	0	0	4
Spermine oxidase	0	1	0	1
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase	0	1	0	1
glucose-6-phosphate 1-dehydrogenase isoform b	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Riboflavin-binding protein	0	0	1	1
Amyloid-beta precursor protein	0	4	0	4
Histidine-rich protein PFHRP-II	0	1	0	2
Spike glycoprotein	0	1	0	1
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	1	0	1
DNA ligase 1	0	1	0	1
Serine/threonine-protein kinase mTOR	0	1	0	1
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Beta-secretase 1	0	3	0	3
Calcium-dependent protein kinase 1	0	0	1	1
MO15-related protein kinase Pfmrk	0	1	0	1
DNA ligase A	0	1	0	1
Phosphoethanolamine N-methyltransferase	0	1	0	1
Cysteine proteinase falcipain 2a	0	1	0	1
Cysteine proteinase falcipain 2a	0	1	0	1
Proteasome subunit beta type-11	0	0	0	1
NADPH oxidase 1	0	2	0	2
Snq2p	0	0	0	5
Adenylate cyclase type 1	0	4	0	4
histone deacetylase 9 isoform 3	4	0	0	4
Proteasome subunit alpha type-7	0	0	0	1
Glutamate receptor ionotropic, NMDA 2D	0	2	0	2
Transient receptor potential cation channel subfamily V member 1	0	2	0	2
Glutamate receptor ionotropic, NMDA 3B	0	2	0	2
Potassium channel subfamily K member 2	0	4	3	7
Albumin	0	1	4	6
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	2	0	2
Major prion protein	0	0	1	1
Cytochrome P450 1A2	0	3	1	5
Cys-loop ligand-gated ion channel	0	1	0	1
Calmodulin-1	0	4	1	5
Cytochrome P450 2D6	0	14	1	16
Polyunsaturated fatty acid lipoxygenase ALOX15	0	5	0	5
Sphingomyelin phosphodiesterase	0	2	0	2
Proteasome subunit beta type-1	0	0	0	1
Adenylate cyclase type 3	0	4	0	4
Proteasome subunit alpha type-1	0	0	0	1
Proteasome subunit alpha type-2	0	0	0	1
Proteasome subunit alpha type-3	0	0	0	1
Proteasome subunit alpha type-4	0	0	0	1
Adenylate cyclase type 2	0	4	0	4
Adenylate cyclase type 4	0	4	0	4
Proteasome subunit beta type-8	0	0	0	1
Proteasome subunit beta type-9	0	0	0	1
Proteasome subunit alpha type-5	0	0	0	1
Proteasome subunit beta type-4	0	0	0	1
Proteasome subunit beta type-6	0	0	0	1
Proteasome subunit beta type-5	0	0	0	1
Pleiotropic ABC efflux transporter of multiple drugs	0	5	0	10
Glutamate receptor ionotropic, NMDA 1	0	5	1	10
Adenylate cyclase type 8	0	4	0	4
Proteasome subunit beta type-10	0	0	0	1
Proteasome subunit beta type-3	0	0	0	1
Proteasome subunit beta type-2	0	0	0	1
Gastrin/cholecystokinin type B receptor	0	3	0	3
Proteasome subunit alpha type-6	0	0	1	2
Calmodulin	0	1	3	4
Aldehyde oxidase 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	5	1	10
Glutamate receptor ionotropic, NMDA 2B	0	5	1	10
Glutamate receptor ionotropic, NMDA 2C	0	5	1	10
Adenylate cyclase type 6	0	4	0	4
Adenylate cyclase type 5	0	4	0	4
Glutamate receptor ionotropic, NMDA 1	0	3	0	3
Aldehyde oxidase	0	2	0	2
Glutamate receptor ionotropic, NMDA 2A	0	3	0	3
Glutamate receptor ionotropic, NMDA 2B	0	3	0	3
Glutamate receptor ionotropic, NMDA 2C	0	2	0	2
Glutamate receptor ionotropic, NMDA 2D	0	5	1	10
Adenylyl cyclase 7	0	4	0	4
Proteasome subunit alpha-type 8	0	0	0	1
Glutamate receptor ionotropic, NMDA 3A	0	2	0	2
Glutamate receptor ionotropic, NMDA 3B	0	5	1	10
Proteasome subunit beta type-7	0	0	0	1
Glutamate receptor ionotropic, NMDA 3A	0	5	1	10
serine-protein kinase ATM isoform a	1	0	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	2	0	0	2
prostaglandin E2 receptor EP2 subtype	0	0	0	1
serine/threonine-protein kinase PLK1	2	0	0	2
Acetylcholinesterase	0	1	0	1
Carboxylic ester hydrolase	0	1	0	1
ORF73	0	0	1	1
Chain A, Acetylcholinesterase	0	0	2	2
Chain A, Acetylcholinesterase	0	0	2	2
Chain A, Acetylcholinesterase	0	0	2	2
Chain A, Acetylcholinesterase	0	0	2	2
Chain A, Acetylcholinesterase	0	0	2	2
Chain A, Acetylcholinesterase	0	0	2	2
Chain A, Acetylcholinesterase	0	0	2	2
Chain A, Putative Glycine Betaine-binding Abc Transporter Protein	0	0	1	1
Chain A, PUTATIVE GLYCINE BETAINE-BINDING ABC TRANSPORTER PROTEIN	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Choline-binding protein	0	0	1	1
Solute carrier family 22 member 1	0	2	0	3
Solute carrier family 22 member 2	0	2	0	2
Acetylcholinesterase	0	14	4	19
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Choline O-acetyltransferase	0	1	0	2
Solute carrier family 22 member 1	0	10	0	11
High affinity choline transporter 1	0	1	0	1
Solute carrier family 22 member 2	0	7	0	8
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	1	0	1
Beta-2 adrenergic receptor	0	5	4	10
Dipeptidyl peptidase 4	0	1	0	1
Insulin receptor	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	3	0	3
5-hydroxytryptamine receptor 4	0	3	1	4
Neutral alpha-glucosidase AB	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
NPC intracellular cholesterol transporter 1 precursor	3	0	0	3
Sodium-dependent noradrenaline transporter	0	2	0	2
Aldo-keto reductase family 1 member B1	0	1	0	1
Aromatase	0	1	0	1
Sigma intracellular receptor 2	0	6	0	6
Sodium-dependent serotonin transporter	0	2	0	2
Sodium-dependent dopamine transporter	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	7	1	8
Transporter	0	15	0	15
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain B, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain A, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain B, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Beta-lactamase	0	1	0	1
Proto-oncogene tyrosine-protein kinase Src	0	1	0	1
3-dehydroquinate dehydratase	0	0	1	1
ATP-citrate synthase	0	0	0	1
Ribonuclease T	0	0	0	1
Cell death-related nuclease 4	0	0	0	1
3-dehydroquinate dehydratase	0	0	1	1
Prolyl 4-hydroxylase	0	1	0	1
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	0	5	0	5
Gamma-aminobutyric acid receptor subunit delta	0	5	0	5
Gamma-aminobutyric acid receptor subunit alpha-1	0	4	0	5
Gamma-aminobutyric acid receptor subunit beta-1	0	4	0	5
Gamma-aminobutyric acid receptor subunit alpha-2	0	4	0	5
Gamma-aminobutyric acid receptor subunit alpha-3	0	4	0	5
Gamma-aminobutyric acid receptor subunit alpha-1	0	6	3	9
Gamma-aminobutyric acid receptor subunit beta-1	0	5	1	6
Gamma-aminobutyric acid receptor subunit gamma-2	0	6	2	8
Gamma-aminobutyric acid receptor subunit alpha-4	0	4	0	5
Gamma-aminobutyric acid receptor subunit gamma-2	0	4	0	5
Gamma-aminobutyric acid receptor subunit beta-3	0	6	2	8
Translocator protein	0	2	0	2
Translocator protein	0	4	0	4
Cholecystokinin receptor type A	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-5	0	5	3	8
Gamma-aminobutyric acid receptor subunit alpha-3	0	5	2	7
Gamma-aminobutyric acid receptor subunit alpha-2	0	5	2	7
Gamma-aminobutyric acid receptor subunit beta-2	0	5	2	7
Gamma-aminobutyric acid receptor subunit alpha-4	0	5	1	6
Gamma-aminobutyric acid receptor subunit epsilon	0	5	0	5
Gamma-aminobutyric acid receptor subunit alpha-6	0	5	1	6
Gamma-aminobutyric acid receptor subunit gamma-1	0	5	0	5
Gamma-aminobutyric acid receptor subunit gamma-3	0	5	0	5
Gamma-aminobutyric acid receptor subunit theta	0	5	0	5
Beta-1 adrenergic receptor	0	2	3	7
Alpha-1B adrenergic receptor	0	0	2	2
Membrane primary amine oxidase	0	1	0	1
Alpha-1A adrenergic receptor	0	2	2	4
Amine oxidase [flavin-containing] A	0	5	0	5
Amine oxidase [flavin-containing] B	0	5	0	5
Adenosine receptor A2b	0	1	1	3
Adenosine receptor A2a	0	1	2	8
Alpha-2B adrenergic receptor	0	0	0	2
Alpha-2C adrenergic receptor	0	0	0	2
Alpha-2A adrenergic receptor	0	0	0	2
Alpha-2A adrenergic receptor	0	1	0	1
Nischarin	0	3	0	3
Nischarin	0	3	0	3
Beta-2 adrenergic receptor	0	8	1	10
Beta-1 adrenergic receptor	0	8	2	12
Endothelin receptor type B	0	2	0	2
5-hydroxytryptamine receptor 3A	0	5	0	5
Endothelin receptor type B	0	2	0	2
Adenosine receptor A1	0	5	0	9
Beta-3 adrenergic receptor	0	5	1	6
5-hydroxytryptamine receptor 2C	0	4	0	4
5-hydroxytryptamine receptor 2A	0	3	0	3
5-hydroxytryptamine receptor 5A	0	1	0	1
D(2) dopamine receptor	0	2	0	2
D(3) dopamine receptor	0	2	0	2
D(2) dopamine receptor	0	4	0	4
5-hydroxytryptamine receptor 2B	0	3	0	3
Transporter	0	5	0	5
Cholecystokinin receptor type A	0	2	0	2
5-hydroxytryptamine receptor 1A	0	2	0	2
Growth hormone secretagogue receptor type 1	0	0	1	1
Growth hormone secretagogue receptor type 1	0	2	2	4
LMP1 [Human herpesvirus 4]	0	0	0	2
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	2	0	2
transactivating tegument protein VP16 [Human herpesvirus 1]	0	2	0	2
nuclear receptor coactivator 3 isoform a	0	2	0	2
Thymidine kinase 2, mitochondrial	0	1	0	1
Thymidine kinase, cytosolic	0	1	0	1
Thymidine kinase	0	1	0	1
Thymidylate synthase	0	2	0	3
Thymidine kinase	0	1	0	1
Deoxycytidine kinase	0	0	0	1
Probable deoxycytidylate deaminase	0	0	0	1
Cytidine deaminase	0	1	0	2
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	1
Thymidine kinase	0	1	0	1
Deoxynucleoside kinase	0	1	0	1
Chain A, Odorant binding protein	0	0	1	1
Chain B, Odorant binding protein	0	0	1	1
Sex hormone-binding globulin	0	0	1	1
Beta-glucuronidase	0	1	0	1
Corticosteroid-binding globulin	0	1	0	1
Beta-glucuronidase	0	1	0	1
Glucose-6-phosphate 1-dehydrogenase	0	4	0	4
G-protein coupled bile acid receptor 1	0	0	1	1
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
NPC1-like intracellular cholesterol transporter 1	0	0	1	1
Solute carrier family 22 member 3	0	1	0	1
Prostaglandin G/H synthase 1	0	5	0	5
Histamine H3 receptor	0	1	0	1
Solute carrier family 22 member 4	0	2	0	2
Phenylethanolamine N-methyltransferase	0	1	0	1
Amine oxidase [flavin-containing] B	0	4	0	4
Amine oxidase [flavin-containing] B	0	3	0	3
Trace amine-associated receptor 1	0	0	1	1
Trace amine-associated receptor 1	0	0	1	1
Trace amine-associated receptor 1	0	0	1	1
Trace amine-associated receptor 1	0	0	1	1
Cocaine esterase	0	3	0	3
Coagulation factor XII	0	1	0	1
Cholinesterase	0	7	0	7
Liver carboxylesterase 1	0	1	0	1
Liver carboxylesterase 1	0	3	0	4
Gamma-aminobutyric acid	0	1	0	1
Fatty acid-binding protein, liver	0	4	0	4
Alpha-1-acid glycoprotein 1	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Sphingosine-1-phosphate lyase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Acetylcholine-binding protein	0	1	0	1
Soluble acetylcholine receptor	0	1	0	1
Beta-2 adrenergic receptor	0	1	2	3
Histamine N-methyltransferase	0	0	0	1
Calcium release-activated calcium channel protein 1	0	1	0	1
Protein orai-2	0	1	0	1
Protein orai-3	0	1	0	1
Histamine H3 receptor	0	0	0	2
Retinoic acid receptor RXR-alpha	0	0	1	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
Acetylcholinesterase	0	5	0	5
Amine oxidase [flavin-containing] A	0	4	0	4
Amine oxidase [flavin-containing] A	0	3	0	3
Acetylcholinesterase	0	5	0	5
Acetylcholinesterase	0	5	0	5
Acetylcholinesterase	0	3	0	3
Glycogen synthase kinase-3 beta	0	1	0	1
Cholinesterase	0	6	1	7
Cholinesterase	0	2	0	2
Acetylcholine receptor subunit epsilon	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	3	0	3
Cytochrome P450 1B1	0	1	0	1
Acyl-CoA:cholesterol acyltransferase	0	1	0	1
Carboxylic ester hydrolase	0	2	0	2
Carboxylic ester hydrolase	0	5	0	5
17-beta-hydroxysteroid dehydrogenase type 1	0	1	0	1
Androgen receptor	0	4	0	4
Peroxisome proliferator-activated receptor alpha	1	0	0	1
Genome polyprotein	0	1	0	1
Acid-sensing ion channel 3	0	1	0	1
Fatty acid-binding protein, intestinal	0	1	0	1
Aldo-keto reductase family 1 member C4	0	1	0	1
Aldo-keto reductase family 1 member C3	0	1	0	1
Aldo-keto reductase family 1 member C2	0	1	0	1
Acid-sensing ion channel 1	0	1	0	1
Aldo-keto reductase family 1 member C1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Solute carrier family 22 member 6	0	1	0	3
Prostaglandin G/H synthase 1	0	2	0	2
Cytochrome P450 1A2	0	1	0	1
Menin	0	0	1	1
Lecithin retinol acyltransferase	0	1	0	1
30S ribosomal protein S6	0	1	0	1
30S ribosomal protein S7	0	1	0	1
50S ribosomal protein L15	0	1	0	1
50S ribosomal protein L10	0	1	0	1
50S ribosomal protein L11	0	1	0	1
50S ribosomal protein L7/L12	0	1	0	1
50S ribosomal protein L19	0	1	0	1
50S ribosomal protein L1	0	1	0	1
50S ribosomal protein L20	0	1	0	1
50S ribosomal protein L27	0	1	0	1
50S ribosomal protein L28	0	1	0	1
50S ribosomal protein L29	0	1	0	1
50S ribosomal protein L31	0	1	0	1
50S ribosomal protein L31 type B	0	1	0	1
50S ribosomal protein L32	0	1	0	1
50S ribosomal protein L33	0	1	0	1
50S ribosomal protein L34	0	1	0	1
50S ribosomal protein L35	0	1	0	1
50S ribosomal protein L36	0	1	0	1
30S ribosomal protein S10	0	1	0	1
30S ribosomal protein S11	0	1	0	1
30S ribosomal protein S12	0	1	0	1
30S ribosomal protein S13	0	1	0	1
30S ribosomal protein S16	0	1	0	1
30S ribosomal protein S18	0	1	0	1
30S ribosomal protein S19	0	1	0	1
30S ribosomal protein S20	0	1	0	1
30S ribosomal protein S2	0	1	0	1
30S ribosomal protein S3	0	1	0	1
30S ribosomal protein S4	0	1	0	1
30S ribosomal protein S5	0	1	0	1
30S ribosomal protein S8	0	1	0	1
30S ribosomal protein S9	0	1	0	1
50S ribosomal protein L13	0	1	0	1
50S ribosomal protein L14	0	1	0	1
50S ribosomal protein L16	0	1	0	1
50S ribosomal protein L23	0	1	0	1
30S ribosomal protein S15	0	1	0	1
50S ribosomal protein L17	0	1	0	1
50S ribosomal protein L21	0	1	0	1
50S ribosomal protein L30	0	1	0	1
50S ribosomal protein L6	0	1	0	1
30S ribosomal protein S14	0	1	0	1
30S ribosomal protein S17	0	1	0	1
30S ribosomal protein S1	0	1	0	1
50S ribosomal protein L18	0	1	0	1
Lethal factor	0	1	0	1
50S ribosomal protein L2	0	1	0	1
50S ribosomal protein L3	0	1	0	1
50S ribosomal protein L24	0	1	0	1
50S ribosomal protein L4	0	1	0	1
50S ribosomal protein L22	0	1	0	1
50S ribosomal protein L5	0	1	0	1
30S ribosomal protein S21	0	1	0	1
50S ribosomal protein L25	0	1	0	1
50S ribosomal protein L36 2	0	1	0	1
Protein Rev	0	0	1	1
Aminoglycoside 3'-phosphotransferase	0	0	0	1
Chain A, ACETYLCHOLINESTERASE	0	1	0	1
Chain A, Acetylcholinesterase	0	1	0	1
Vascular endothelial growth factor receptor 1	0	1	0	1
Vascular endothelial growth factor receptor 3	0	1	0	1
Vascular endothelial growth factor receptor 2	0	1	0	1
Prolyl endopeptidase	0	1	0	1
Small conductance calcium-activated potassium channel protein 3	0	1	0	1
Rap guanine nucleotide exchange factor 3	5	0	0	5
POU domain, class 2, transcription factor 1	0	0	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	3	0	3
UDP-glucuronosyltransferase 1A9	0	1	0	4
Vitamin D-binding protein	0	1	0	1
Integrin beta-1	0	1	0	1
Integrin alpha-4	0	1	0	1
Carbonyl reductase [NADPH] 1	0	0	0	1
C-8 sterol isomerase	0	1	0	1
Delta-type opioid receptor	0	3	0	3
Mu-type opioid receptor	0	4	0	4
Kappa-type opioid receptor	0	2	0	2
5-hydroxytryptamine receptor 2A	0	1	0	1
AP-2 complex subunit sigma	0	1	0	1
N-acetyltransferase Eis	0	2	0	2
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	1	0	1
Calcitonin gene-related peptide type 1 receptor	0	1	0	1
Genome polyprotein	0	2	0	2
Zinc finger protein 664	0	1	0	1
Vesicular acetylcholine transporter	0	1	0	1
Protease	0	2	0	2
Transient receptor potential cation channel subfamily V member 4	0	1	0	1
Transient receptor potential cation channel subfamily V member 2	0	1	0	1
Chain A, HISTIDINE-BINDING PROTEIN	0	0	1	1
Plasma kallikrein	0	0	0	4
Histidine-binding periplasmic protein	0	0	1	1
5-hydroxytryptamine receptor 1D	0	1	0	2
Carbonic anhydrase	0	1	0	5
Large neutral amino acids transporter small subunit 1	0	4	0	4
Carbonic anhydrase	0	1	0	5
Carbonic anhydrase	0	0	0	4
Carbonic anhydrase	0	1	0	5
Carbonic anhydrase	0	1	0	5
Carbonic anhydrase 4	0	1	0	2
Carbonic anhydrase 13	0	0	0	3
Envelope glycoprotein	0	0	2	2
Chain A, Cell Division Protein Kinase 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, Cell Division Protein Kinase 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, Cell Division Protein Kinase 2	0	1	0	1
DNA repair and recombination protein RadA	0	0	1	1
Cyclin-dependent kinase 1	0	1	0	1
Heat shock protein HSP 90-alpha	0	0	1	1
G2/mitotic-specific cyclin-B1	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	1	3
Cyclin-A2	0	1	0	1
Cyclin-dependent kinase 2	0	1	1	2
RAC-alpha serine/threonine-protein kinase	0	1	0	1
Cyclin-A1	0	1	0	1
Chain A, Acetylcholinesterase	0	1	0	1
interferon gamma precursor	0	0	0	1
Interstitial collagenase	0	1	0	1
NPYLR7B	0	0	1	1
beta-2 adrenergic receptor	2	0	0	2
hexokinase-4 isoform 1	2	0	0	2
glucokinase regulatory protein	2	0	0	2
Beta-2 adrenergic receptor	0	0	1	1
Beta-adrenergic receptor kinase 1	0	0	1	1
Beta-3 adrenergic receptor	0	0	1	1
Beta-1 adrenergic receptor	0	2	1	3
Beta-2 adrenergic receptor	0	2	0	2
Taste receptor type 2 member 38	0	0	1	1
Taste receptor type 2 member 39	0	0	1	1
Taste receptor type 2 member 40	0	0	1	1
Taste receptor type 2 member 41	0	0	1	1
Taste receptor type 2 member 43	0	0	1	1
Taste receptor type 2 member 31	0	0	1	1
Taste receptor type 2 member 45	0	0	1	1
Taste receptor type 2 member 46	0	0	1	1
Taste receptor type 2 member 30	0	0	1	1
Taste receptor type 2 member 19	0	0	1	1
Taste receptor type 2 member 20	0	0	1	1
Taste receptor type 2 member 50	0	0	1	1
Taste receptor type 2 member 60	0	0	1	1
Taste receptor type 2 member 42	0	0	1	1
Beta-2 adrenergic receptor	0	1	3	5
Taste receptor type 2 member 16	0	0	1	1
Taste receptor type 2 member 14	0	0	1	2
Taste receptor type 2 member 13	0	0	1	1
Taste receptor type 2 member 10	0	0	1	1
Taste receptor type 2 member 9	0	0	1	1
Taste receptor type 2 member 8	0	0	1	1
Taste receptor type 2 member 7	0	0	1	1
Taste receptor type 2 member 5	0	0	1	1
Taste receptor type 2 member 4	0	0	1	1
Taste receptor type 2 member 3	0	0	1	1
Taste receptor type 2 member 1	0	0	1	1
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	1	0	0	1
Chymotrypsinogen A	0	1	0	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
Synaptic vesicle glycoprotein 2A	0	2	0	2
WRN	2	0	0	2
integrase, partial	0	1	0	1
lens epithelium-derived growth factor p75	0	1	0	1
pyruvate kinase	2	0	0	2
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
Polyphenol oxidase 2	0	0	0	2
Tyrosinase	0	1	0	1
SLC16A10 protein	0	0	0	3
Monocarboxylate transporter 10	0	0	0	3
phosphoglycerate kinase	2	0	0	2
Potassium channel subfamily K member 3	0	2	0	2
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
Potassium voltage-gated channel subfamily D member 2	0	1	0	1
Potassium channel subfamily K member 18	0	1	0	1
M17 leucyl aminopeptidase	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
galanin receptor type 3	0	1	0	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
ClpP	2	0	0	2
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	1	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	5	0	6
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Tyrosine-protein kinase ABL1	0	0	1	1
Thymidylate synthase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
High mobility group protein B1	0	0	1	1
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	2	2	4
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Histidine decarboxylase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Bifunctional purine biosynthesis protein ATIC	0	2	0	2
Multidrug resistance-associated protein 1	0	0	0	1
Reduced folate transporter	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
6-phosphogluconate dehydrogenase, decarboxylating	0	2	0	2
Solute carrier organic anion transporter family member 1A3	0	0	0	1
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	3	0	3
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Solute carrier family 22 member 20	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Solute carrier family 22 member 8	0	2	0	3
Solute carrier family 22 member 6	0	1	0	1
Dihydrofolate reductase	0	1	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Multidrug resistance associated protein	0	1	0	2
Solute carrier family 22 member 11	0	0	0	1
Protein-arginine deiminase type-4	0	3	0	3
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	1	0	2
nuclear receptor subfamily 1, group I, member 2	1	0	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Glucocorticoid receptor	0	4	1	5
Glycine receptor subunit alpha-1	0	4	0	4
Glycine receptor subunit beta	0	4	0	4
Glycine receptor subunit alpha-2	0	4	0	4
Glycine receptor subunit alpha-3	0	4	0	4
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Myeloperoxidase	0	2	0	2
Lactoperoxidase	0	1	0	1
5-hydroxytryptamine receptor 3B	0	3	0	3
Endothelin-1 receptor	0	2	1	3
Type-2 angiotensin II receptor	0	2	0	2
G-protein coupled receptor	0	1	0	1
N-glycosylase/DNA lyase	0	1	0	1
Lysine-specific demethylase 4C	0	2	0	2
FAD-linked sulfhydryl oxidase ALR	0	0	0	1
Solute carrier family 2, facilitated glucose transporter member 9	0	2	2	4
MCOLN3 protein	0	0	1	1
transient receptor potential cation channel, subfamily N, member 1	0	0	1	1
Muscarinic acetylcholine receptor DM1	0	3	0	3
Mineralocorticoid receptor	0	0	1	1
MBT domain-containing protein 1	0	1	0	1
Lethal(3)malignant brain tumor-like protein 4	0	1	0	1
Lethal(3)malignant brain tumor-like protein 3	0	1	0	1
Lethal(3)malignant brain tumor-like protein 1	0	1	0	1
Valosin-containing protein	0	1	0	1
microphthalmia-associated transcription factor isoform 9	0	1	0	1
eukaryotic translation initiation factor 4 gamma 1 isoform 4	0	1	0	1
eukaryotic translation initiation factor 4E isoform 1	0	1	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	0	0	1
Serum paraoxonase/arylesterase 1	0	1	0	1
Photosystem I iron-sulfur center	0	0	0	1
Cystathionine gamma-lyase	0	1	0	1
Hsf1 protein	0	0	2	3
estrogen receptor beta isoform 1	0	1	0	1
Alpha-1A adrenergic receptor	0	0	1	1
Alpha-1B adrenergic receptor	0	2	0	2
Estrogen receptor 1	0	1	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
fMet-Leu-Phe receptor	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Cyclooxygenase-2	0	1	0	1
Fatty acid-binding protein, liver	0	1	0	1
Cytochrome P450 2A6	0	2	1	3
Cytochrome P450 2A13	0	1	1	2
Peroxisomal sarcosine oxidase	0	0	0	1
Muscarinic acetylcholine receptor M5	0	1	0	1
Sterol O-acyltransferase 1	0	1	0	1
DNA (cytosine-5)-methyltransferase 1	0	1	0	1
Sterol O-acyltransferase 1	0	1	0	1
DNA (cytosine-5)-methyltransferase 3-like	0	1	0	1
DNA (cytosine-5)-methyltransferase 3A	0	1	0	1
Mcl-1	0	1	0	1
neutrophil cytosol factor 1	0	1	0	1
Chloroquine resistance transporter	0	1	0	1
heat shock protein HSP 90-alpha isoform 2	0	0	0	1
heat shock protein 90, putative	0	0	0	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
UDP-glucuronosyltransferase 1A8	0	0	0	1
Cytochrome P450 2C8	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
5-hydroxytryptamine receptor 1B	0	2	1	3
Adenosine receptor A2a	0	3	3	7
Neuromedin-K receptor	0	0	1	1
Type-1 angiotensin II receptor	0	1	1	2
Cholecystokinin receptor type A	0	1	1	2
Sodium/bile acid cotransporter	0	1	0	1
Nuclear receptor subfamily 2 group E member 1	0	0	2	2
Pyridoxal kinase	0	0	0	1
Chain A, dATP pyrophosphohydrolase	0	1	0	1
Chain A, Adenylate cyclase type 5	0	1	0	1
Chain B, Adenylate cyclase type 2	0	1	0	1
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
DNA dC->dU-editing enzyme APOBEC-3F isoform a	1	0	0	1
Quinolone resistance protein NorA	0	1	0	2
Chromaffin granule amine transporter	0	1	0	1
Synaptic vesicular amine transporter	0	1	0	1
Synaptic vesicular amine transporter	0	2	1	3
Synaptic vesicular amine transporter	0	1	0	1
pyruvate kinase PKM isoform b	1	0	0	1
Ornithine decarboxylase	1	0	0	1
Acyl-CoA desaturase 1	0	1	0	1
Acetylcholine receptor subunit epsilon	0	1	0	1
Cholinesterase	0	1	0	1
Tyrosine-protein kinase SYK	0	1	0	1
Transcriptional activator protein LuxR	0	1	0	1
3-oxo-5-alpha-steroid 4-dehydrogenase 2	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	0	0	1
Substance-P receptor	0	2	0	2
Neuromedin-K receptor	0	0	1	1
Substance-K receptor	0	1	1	2
Neuromedin-K receptor	0	1	1	2
Substance-P receptor	0	2	0	2
Substance-K receptor	0	1	0	1
Substance-K receptor	0	1	0	1
Mas-related G-protein coupled receptor member X2	0	0	1	1
Chain A, MALTOPORIN	0	0	1	1
Chain B, MALTOPORIN	0	0	1	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Beta-carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase, alpha family	0	1	0	1
Carbonic anhydrase	0	1	0	1
Delta carbonic anhydrase	0	1	0	1
D(2) dopamine receptor	0	1	0	1
Chain A, Alpha-mannosidase Ii	0	1	0	1
Chain A, ALPHA-MANNOSIDASE II	0	1	0	1
Chain A, Alpha-mannosidase Ii	0	1	0	1
Lysosomal alpha-mannosidase	0	1	0	1
Alpha-mannosidase 2C1	0	1	0	1
Mannosyl-oligosaccharide alpha-1,2-mannosidase IA	0	2	0	2
Alpha-mannosidase 2	0	1	0	1
Alpha-1,2-mannosidase family protein	0	1	0	1
Putative alpha-1,2-mannosidase	0	1	0	1
Alpha-1,2-mannosidase, putative	0	1	0	1
Putative alpha-1,2-mannosidase	0	1	0	1
Putative alpha-1,2-mannosidase	0	1	0	1
Putative alpha-1,2-mannosidase	0	1	0	1
Putative alpha-1,2-mannosidase	0	1	0	1
Glycoside hydrolase family 92	0	1	0	1
Glycoside hydrolase family 92	0	1	0	1
Alpha-1,2-mannosidase	0	1	0	1
Putative alpha-1,2-mannosidase	0	1	0	1
Alpha-1,2-mannosidase, putative	0	1	0	1
Putative alpha-1,2-mannosidase	0	1	0	1
Alpha-1,2-mannosidase	0	1	0	1
Alpha-1,2-mannosidase, putative	0	1	0	1
Putative alpha-1,2-mannosidase	0	1	0	1
Putative alpha-1,2-mannosidase	0	1	0	1
Alpha-1,2-mannosidase	0	1	0	1
Putative alpha-1,2-mannosidase	0	1	0	1
Putative alpha-1,2-mannosidase	0	1	0	1
Putative alpha-1,2-mannosidase	0	1	0	1
Putative alpha-1,2-mannosidase	0	1	0	1
Alpha-1,2-mannosidase family protein	0	1	0	1
alpha-1,2-Mannosidase	0	1	0	1
Chain A, Pyridoxal kinase	0	1	0	1
Chain A, Pyridoxal Kinase	0	1	0	1
Phosphodiesterase	0	2	0	2
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	3	0	3
Intestinal-type alkaline phosphatase	0	2	0	2
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Thyroid hormone receptor beta	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	2	0	2
Adenosine receptor A1	0	2	0	2
Adenosine receptor A3	0	1	0	1
Adenosine receptor A2b	0	1	0	2
Adenosine receptor A1	0	2	1	5
Vasopressin V2 receptor	0	0	0	1
Adenosine receptor A2a	0	1	0	1
Adenosine receptor A1	0	1	0	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	1	0	1
Adenosine receptor A1	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	2	0	2
Adenylate cyclase type 1	0	0	0	1
Chitotriosidase-1	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	1	0	1
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	1	0	1
Adenosine receptor A2b	0	0	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	0	1	1
Endochitinase B1	0	1	0	1
Phospholipase A-2-activating protein	0	2	0	2
Chain A, ykoF	0	0	1	1
Chain B, ykoF	0	0	1	1
Chain A, ThiT	0	0	1	1
Thiamine transporter ThiT	0	0	1	1
Transketolase	0	0	1	1
Thiamine-binding periplasmic protein	0	0	1	1
Chain A, PLASMINOGEN	0	0	1	1
Chain A, PLASMINOGEN	0	0	1	1
Plasminogen	0	2	1	3
Urokinase-type plasminogen activator	0	1	0	1
Chain A, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain K, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain B, tryptophanyl-tRNA synthetase	0	0	1	1
Chain C, Tryptophanyl-tRNA synthetase II	0	0	1	1
Stromelysin-1	0	1	0	1
Tryptophan 2,3-dioxygenase	0	1	0	2
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Tryprostatin B synthase	0	0	0	1
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	0	0	1	1
Chain A, CHORISMATE MUTASE	0	1	0	1
Chain A, TYROSYL-tRNA SYNTHETASE	0	0	1	1
Tubulin--tyrosine ligase	0	1	0	1
Urease subunit alpha	0	1	0	1
Urease subunit beta	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Guanine deaminase	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member B7	0	1	0	1
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

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Studies (426)

Protein Targets (1,326)

Drooling

Synonyms(2)

Research Excerpts

Overview

Context

Actions

Treatment

Research

Studies (426)

Drugs Studied (227)

Protein Targets (1,326)