ketamine has been researched along with Bone Fractures in 36 studies
Ketamine: A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.
ketamine : A member of the class of cyclohexanones in which one of the hydrogens at position 2 is substituted by a 2-chlorophenyl group, while the other is substituted by a methylamino group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We report a case of allergic reaction associated with the administration of intravenous ketamine for procedural sedation in a 16-year-old male." | 7.85 | Allergic Reaction to Ketamine as Monotherapy for Procedural Sedation. ( Baker, B; Ferguson, JD; Nguyen, TT, 2017) |
| "5 μg/kg intranasal fentanyl in children 4 to 17 years old with acute pain from suspected isolated extremity fractures presenting to an urban Level II pediatric trauma center from December 2015 to November 2016." | 5.24 | Randomized Controlled Feasibility Trial of Intranasal Ketamine Compared to Intranasal Fentanyl for Analgesia in Children with Suspected Extremity Fractures. ( Bryant, KK; Dunn, C; Hogg, M; Moore, CG; Reynolds, SL; Runyon, MS; Studnek, JR; Templin, MA; Walker, KR; Young, JR, 2017) |
| " Before fracture reduction, children 3 to 17 years of age randomly received 2% lidocaine (L) or normal saline (NS) into the hematoma of their fracture site during sedation with intravenous ketamine and midazolam." | 5.19 | Evaluating the hematoma block as an adjunct to procedural sedation for closed reduction of distal forearm fractures. ( Constantine, E; Eberson, CP; Linakis, JG; Machan, JT; Steele, DW; Tsze, DS, 2014) |
| "The authors performed a prospective, double-blinded, randomized trial with emergency department (ED) patients requiring procedural sedation and analgesia (PSA) for repair of deep traumatic lacerations and reduction of bone fractures, to compare the ketamine/propofol (ketofol) combination with the midazolam/fentanyl (MF) combination." | 5.15 | Ketamine/propofol versus midazolam/fentanyl for procedural sedation and analgesia in the emergency department: a randomized, prospective, double-blind trial. ( Ashraf, H; Golshani, K; Labaf, A; Moharari, RS; Nejati, A, 2011) |
| "We report a case of allergic reaction associated with the administration of intravenous ketamine for procedural sedation in a 16-year-old male." | 3.85 | Allergic Reaction to Ketamine as Monotherapy for Procedural Sedation. ( Baker, B; Ferguson, JD; Nguyen, TT, 2017) |
| "Unit medical protocols authorize ketamine for tourniquet pain, amputations, long-bone fractures, and pain refractory to other agents." | 3.80 | Prehospital analgesia with ketamine for combat wounds: a case series. ( Conklin, CC; Fisher, AD; Mabry, RL; Rippee, B; Shehan, H, 2014) |
| "A total of 29 peafowl (Pavo cristatus), rectified surgically for infraorbital abscesses (n = 22), lacerated wounds (n = 4), and fractures of tibia (n = 2) and radius (n = 1), were anaesthetized by the intravenous administration of ketamine hydrochloride (Inj." | 3.69 | Clinical perspectives of intravenous ketamine anaesthesia in peafowl (Pavo cristatus). ( Athar, M; Chaudhry, NI; Muhammad, G; Sarwar, MN; Shakoor, A, 1996) |
| "Ketamine, which has longer action times, might be preferred for reductions because orthopedic procedures could be lengthy." | 2.82 | Etomidate Versus Ketamine: Effective Use in Emergency Procedural Sedation for Pediatric Orthopedic Injuries. ( Avci, A; Dişel, NR; Sertdemir, Y; Yeşilağaç, H; Yilmaz, HL, 2016) |
| " With 20 microgram/ml remifentanil in normal saline, postoperative PCA was administered with a background infusion at 2 ml/h following 2 ml as a loading dose and 1ml demand dose with a 3-minute lockout period." | 2.74 | Remifentanil combined with low-dose ketamine for postoperative analgesia of lower limb fracture: a double-blind, controlled study. ( Deng, GF; Tian, B; Wang, S; Zhang, SG; Zheng, JP, 2009) |
| "The frequency of psychosis emergence or confusion (54%) in Group A during the first 48 hours after surgery was significantly higher than the 30% figure in Group B." | 2.70 | Anesthesia with ketamine, propofol, and fentanyl decreases the frequency of postoperative psychosis emergence and confusion in schizophrenic patients. ( Katagai, H; Kudoh, A; Takazawa, T, 2002) |
| "Prospective observational study of adverse events (AEs) related to pediatric ED specialists' use of analgesia and sedation when reducing fractures in children under the age of 14 years between 2011 and 2019." | 1.72 | Safety of ketamine for reducing fractures in a pediatric emergency department. ( Benito, J; García, S; Intxauspe Maritxalar, A; Lejarzegi Anakabe, E; Mintegi, S; Olabarri, M, 2022) |
| " Adverse events during pediatric PSA that pose the most risk to patient safety involve airway compromise." | 1.48 | Higher Mallampati Scores Are Not Associated with More Adverse Events During Pediatric Procedural Sedation and Analgesia. ( Iyer, MS; Pitetti, RD; Vitale, M, 2018) |
| "Fentanyl was preferred for paediatric patients and ketamine was preferentially administered for severe pain by physicians who had more medical experience or had trained in anaesthesia." | 1.43 | A two-year retrospective review of the determinants of pre-hospital analgesia administration by alpine helicopter emergency medical physicians to patients with isolated limb injury. ( Albrecht, E; Eidenbenz, D; Hugli, O; Pasquier, M; Taffé, P, 2016) |
| "Isoflurane anaesthesia was maintained at 0." | 1.40 | Use of brachial plexus blockade and medetomidine-ketamine-isoflurane anaesthesia for repair of radio-ulna fracture in an adult cheetah (Acinonyx jubatus). ( Kariuki, E; Kimeli, P; Kipyegon, AN; Kirui, G; Mande, JD; Mijele, D; Mogoa, EM; Muasya, DW; Mwangi, WE, 2014) |
| "Ketamine hydrochloride was administered intravenously (at a dose of less than two milligrams per kilogram of body weight) in ninety-nine of the patients and intramuscularly (at a dose of four milligrams per kilogram of body weight) in the other fifteen." | 1.32 | Sedation with ketamine: a safe and effective anaesthetic agent for children in the developing world. ( Prasad, N; Shah, RK; Singh, RP, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (13.89) | 18.7374 |
| 1990's | 2 (5.56) | 18.2507 |
| 2000's | 9 (25.00) | 29.6817 |
| 2010's | 18 (50.00) | 24.3611 |
| 2020's | 2 (5.56) | 2.80 |
| Authors | Studies |
|---|---|
| Olabarri, M | 1 |
| Lejarzegi Anakabe, E | 1 |
| García, S | 1 |
| Intxauspe Maritxalar, A | 1 |
| Benito, J | 1 |
| Mintegi, S | 1 |
| Halim, AA | 1 |
| Alsayed, B | 1 |
| Embarak, S | 1 |
| Yaseen, T | 1 |
| Dabbous, S | 1 |
| Fontaine, O | 1 |
| Dueluzeau, R | 1 |
| Raibaud, P | 1 |
| Chabanet, C | 1 |
| Popoff, MR | 1 |
| Badoual, J | 1 |
| Gabilan, JC | 1 |
| Andremont, A | 1 |
| Gómez, L | 1 |
| Andrés, S | 1 |
| Sánchez, J | 1 |
| Alonso, JM | 1 |
| Rey, J | 1 |
| López, F | 1 |
| Jiménez, A | 1 |
| Yan, Z | 1 |
| Zhou, L | 1 |
| Zhao, Y | 3 |
| Wang, J | 6 |
| Huang, L | 2 |
| Hu, K | 1 |
| Liu, H | 4 |
| Wang, H | 3 |
| Guo, Z | 1 |
| Song, Y | 1 |
| Huang, H | 4 |
| Yang, R | 1 |
| Owen, TW | 1 |
| Al-Kaysi, RO | 1 |
| Bardeen, CJ | 1 |
| Cheng, Q | 1 |
| Wu, S | 1 |
| Cheng, T | 1 |
| Zhou, X | 1 |
| Wang, B | 4 |
| Zhang, Q | 4 |
| Wu, X | 2 |
| Yao, Y | 3 |
| Ochiai, T | 1 |
| Ishiguro, H | 2 |
| Nakano, R | 2 |
| Kubota, Y | 2 |
| Hara, M | 1 |
| Sunada, K | 1 |
| Hashimoto, K | 1 |
| Kajioka, J | 1 |
| Fujishima, A | 1 |
| Jiao, J | 3 |
| Gai, QY | 3 |
| Wang, W | 2 |
| Zang, YP | 2 |
| Niu, LL | 2 |
| Fu, YJ | 3 |
| Wang, X | 4 |
| Yao, LP | 1 |
| Qin, QP | 1 |
| Wang, ZY | 1 |
| Liu, J | 4 |
| Aleksic Sabo, V | 1 |
| Knezevic, P | 1 |
| Borges-Argáez, R | 1 |
| Chan-Balan, R | 1 |
| Cetina-Montejo, L | 1 |
| Ayora-Talavera, G | 1 |
| Sansores-Peraza, P | 1 |
| Gómez-Carballo, J | 1 |
| Cáceres-Farfán, M | 1 |
| Jang, J | 1 |
| Akin, D | 1 |
| Bashir, R | 1 |
| Yu, Z | 1 |
| Zhu, J | 2 |
| Jiang, H | 1 |
| He, C | 2 |
| Xiao, Z | 1 |
| Xu, J | 2 |
| Sun, Q | 1 |
| Han, D | 1 |
| Lei, H | 1 |
| Zhao, K | 2 |
| Zhu, L | 1 |
| Li, X | 4 |
| Fu, H | 2 |
| Wilson, BK | 1 |
| Step, DL | 1 |
| Maxwell, CL | 1 |
| Gifford, CA | 1 |
| Richards, CJ | 1 |
| Krehbiel, CR | 1 |
| Warner, JM | 1 |
| Doerr, AJ | 1 |
| Erickson, GE | 1 |
| Guretzky, JA | 1 |
| Rasby, RJ | 1 |
| Watson, AK | 1 |
| Klopfenstein, TJ | 1 |
| Sun, Y | 4 |
| Liu, Z | 3 |
| Pham, TD | 1 |
| Lee, BK | 1 |
| Yang, FC | 1 |
| Wu, KH | 1 |
| Lin, WP | 1 |
| Hu, MK | 1 |
| Lin, L | 3 |
| Shao, J | 1 |
| Sun, M | 1 |
| Xu, G | 1 |
| Zhang, X | 6 |
| Xu, N | 1 |
| Wang, R | 1 |
| Liu, S | 1 |
| He, H | 1 |
| Dong, X | 2 |
| Yang, M | 2 |
| Yang, Q | 1 |
| Duan, S | 1 |
| Yu, Y | 2 |
| Han, J | 2 |
| Zhang, C | 3 |
| Chen, L | 2 |
| Yang, X | 1 |
| Li, W | 3 |
| Wang, T | 2 |
| Campbell, DA | 1 |
| Gao, K | 1 |
| Zager, RA | 1 |
| Johnson, ACM | 1 |
| Guillem, A | 1 |
| Keyser, J | 1 |
| Singh, B | 1 |
| Steubl, D | 1 |
| Schneider, MP | 1 |
| Meiselbach, H | 1 |
| Nadal, J | 1 |
| Schmid, MC | 1 |
| Saritas, T | 1 |
| Krane, V | 1 |
| Sommerer, C | 1 |
| Baid-Agrawal, S | 1 |
| Voelkl, J | 1 |
| Kotsis, F | 1 |
| Köttgen, A | 1 |
| Eckardt, KU | 1 |
| Scherberich, JE | 1 |
| Li, H | 4 |
| Yao, L | 2 |
| Sun, L | 3 |
| Zhu, Z | 1 |
| Naren, N | 1 |
| Zhang, XX | 2 |
| Gentile, GL | 1 |
| Rupert, AS | 1 |
| Carrasco, LI | 1 |
| Garcia, EM | 1 |
| Kumar, NG | 1 |
| Walsh, SW | 1 |
| Jefferson, KK | 1 |
| Guest, RL | 1 |
| Samé Guerra, D | 1 |
| Wissler, M | 2 |
| Grimm, J | 1 |
| Silhavy, TJ | 1 |
| Lee, JH | 2 |
| Yoo, JS | 1 |
| Kim, Y | 1 |
| Kim, JS | 2 |
| Lee, EJ | 1 |
| Roe, JH | 1 |
| Delorme, M | 1 |
| Bouchard, PA | 1 |
| Simon, M | 1 |
| Simard, S | 1 |
| Lellouche, F | 1 |
| D'Urzo, KA | 1 |
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| D'Urzo, AD | 1 |
| Koneru, B | 1 |
| Lopez, G | 1 |
| Farooqi, A | 1 |
| Conkrite, KL | 1 |
| Nguyen, TH | 1 |
| Macha, SJ | 1 |
| Modi, A | 1 |
| Rokita, JL | 1 |
| Urias, E | 1 |
| Hindle, A | 1 |
| Davidson, H | 1 |
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| Irwin, MS | 1 |
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| Wheeler, DA | 1 |
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| Reynolds, CP | 1 |
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| Sheeba, V | 1 |
| Hartley, AM | 2 |
| Meunier, B | 2 |
| Pinotsis, N | 1 |
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| Xu, JY | 1 |
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| Haraux, F | 1 |
| Rich, PR | 1 |
| Kamalanathan, M | 1 |
| Doyle, SM | 1 |
| Xu, C | 1 |
| Achberger, AM | 1 |
| Wade, TL | 1 |
| Schwehr, K | 1 |
| Santschi, PH | 1 |
| Sylvan, JB | 1 |
| Quigg, A | 1 |
| Leong, W | 1 |
| Xu, W | 2 |
| Gao, S | 1 |
| Zhai, X | 1 |
| Wang, C | 2 |
| Gilson, E | 1 |
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| Lu, Y | 1 |
| Yan, R | 1 |
| Zhang, Y | 6 |
| Hu, Z | 1 |
| You, Q | 1 |
| Cai, Q | 1 |
| Yang, D | 1 |
| Gu, S | 1 |
| Dai, H | 1 |
| Zhao, X | 1 |
| Gui, C | 1 |
| Gui, J | 1 |
| Wu, PK | 1 |
| Hong, SK | 1 |
| Starenki, D | 1 |
| Oshima, K | 1 |
| Shao, H | 1 |
| Gestwicki, JE | 1 |
| Tsai, S | 1 |
| Park, JI | 1 |
| Wang, Y | 7 |
| Zhao, R | 1 |
| Gu, Z | 1 |
| Dong, C | 2 |
| Guo, G | 1 |
| Li, L | 4 |
| Barrett, HE | 1 |
| Meester, EJ | 1 |
| van Gaalen, K | 1 |
| van der Heiden, K | 1 |
| Krenning, BJ | 1 |
| Beekman, FJ | 1 |
| de Blois, E | 1 |
| de Swart, J | 1 |
| Verhagen, HJ | 1 |
| Maina, T | 1 |
| Nock, BA | 1 |
| Norenberg, JP | 1 |
| de Jong, M | 1 |
| Gijsen, FJH | 1 |
| Bernsen, MR | 1 |
| Martínez-Milla, J | 1 |
| Galán-Arriola, C | 1 |
| Carnero, M | 1 |
| Cobiella, J | 1 |
| Pérez-Camargo, D | 1 |
| Bautista-Hernández, V | 1 |
| Rigol, M | 1 |
| Solanes, N | 1 |
| Villena-Gutierrez, R | 1 |
| Lobo, M | 1 |
| Mateo, J | 1 |
| Vilchez-Tschischke, JP | 1 |
| Salinas, B | 1 |
| Cussó, L | 1 |
| López, GJ | 1 |
| Fuster, V | 1 |
| Desco, M | 1 |
| Sanchez-González, J | 1 |
| Ibanez, B | 1 |
| van den Berg, P | 1 |
| Schweitzer, DH | 1 |
| van Haard, PMM | 1 |
| Geusens, PP | 1 |
| van den Bergh, JP | 1 |
| Zhu, X | 1 |
| Huang, X | 2 |
| Xu, H | 2 |
| Yang, G | 2 |
| Lin, Z | 1 |
| Salem, HF | 1 |
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| Kharshoum, RM | 1 |
| Abd El-Ghafar, OA | 1 |
| Farouk, HO | 1 |
| Domiciano, D | 1 |
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| de Carvalho, PA | 1 |
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| de Souza, LB | 1 |
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| Liu, Y | 7 |
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| Konggidinata, MI | 1 |
| Gallo, AA | 1 |
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| Yang, TWW | 1 |
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| Burton, PR | 1 |
| Earnest, A | 1 |
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| Doddipatla, S | 1 |
| Thomas, AM | 1 |
| Nikolayev, AA | 1 |
| Galimova, GR | 1 |
| Azyazov, VN | 1 |
| Mebel, AM | 1 |
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| Yang, P | 1 |
| Yu, X | 2 |
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| Zhang, H | 1 |
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| Han, B | 1 |
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| Ganschow, S | 1 |
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| Hayton, TW | 1 |
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| Herrmann, TRW | 1 |
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| Dai, W | 1 |
| Shi, J | 2 |
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| Kloner, RA | 1 |
| Pickersgill, NA | 1 |
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| Känsäkoski, P | 1 |
| Rysä, J | 1 |
| Hakkola, J | 1 |
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| Du, Q | 1 |
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| Cao, X | 1 |
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| Zhao, S | 1 |
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| Gonzalez-Cotto, M | 1 |
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| Collado, CJ | 1 |
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| Deng, Z | 1 |
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| Tang, J | 3 |
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| Zhao, D | 1 |
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| Zhou, Z | 1 |
| Niu, PP | 1 |
| Song, B | 1 |
| Xu, YM | 1 |
| Zhang, Z | 2 |
| Qiu, N | 1 |
| Yin, J | 1 |
| Zhang, J | 3 |
| Guo, W | 1 |
| Liu, M | 2 |
| Liu, T | 2 |
| Chen, D | 5 |
| Luo, K | 1 |
| He, Z | 2 |
| Zheng, G | 1 |
| Xu, F | 1 |
| Sun, W | 1 |
| Yin, F | 1 |
| van Hest, JCM | 1 |
| Du, L | 2 |
| Shi, X | 1 |
| Kang, S | 1 |
| Duan, W | 1 |
| Zhang, S | 2 |
| Feng, J | 2 |
| Qi, N | 1 |
| Shen, G | 1 |
| Ren, H | 1 |
| Shang, Q | 1 |
| Zhao, W | 2 |
| Yang, Z | 2 |
| Jiang, X | 2 |
| Alame, M | 1 |
| Cornillot, E | 1 |
| Cacheux, V | 1 |
| Tosato, G | 1 |
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| De Oliveira, L | 1 |
| Gofflot, S | 1 |
| Delvenne, P | 1 |
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| Cabello-Aguilar, S | 1 |
| Nishiyama, M | 1 |
| Turtoi, A | 1 |
| Costes-Martineau, V | 1 |
| Colinge, J | 1 |
| Guo, Q | 1 |
| Quan, M | 1 |
| Dong, J | 1 |
| Bai, J | 1 |
| Han, R | 1 |
| Cai, Y | 1 |
| Lv, YQ | 1 |
| Chen, Q | 1 |
| Lyu, HD | 1 |
| Deng, L | 1 |
| Zhou, D | 1 |
| Xiao, X | 1 |
| De Langhe, S | 1 |
| Billadeau, DD | 1 |
| Lou, Z | 1 |
| Zhang, JS | 1 |
| Xue, Z | 1 |
| Shen, XD | 1 |
| Gao, F | 1 |
| Busuttil, RW | 1 |
| Kupiec-Weglinski, JW | 1 |
| Ji, H | 1 |
| Otano, I | 1 |
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| Minute, L | 1 |
| Ochoa, MC | 1 |
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| Avci, A | 1 |
| Eidenbenz, D | 1 |
| Taffé, P | 1 |
| Hugli, O | 1 |
| Albrecht, E | 1 |
| Pasquier, M | 1 |
| Bryant, K | 1 |
| VanderHave, K | 1 |
| Grossman, E | 1 |
| Young, J | 1 |
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| Chéron, G | 1 |
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| Acar, AY | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Randomized Controlled Trial of Intranasal Ketamine Compared to Intranasal Fentanyl for Analgesia in Children With Suspected, Isolated Extremity Fractures in the Pediatric Emergency Department[NCT02521415] | Phase 2 | 87 participants (Actual) | Interventional | 2015-12-31 | Completed | ||
| Comparison Between Efficacy of Ketamine and Propofol Mixture With 1:6 Ratio and 1:4 Ratio for Endoscopic Retrograde Procedure Sedation[NCT03196479] | 58 participants (Actual) | Interventional | 2017-03-01 | Completed | |||
| A Randomized Double-blind Trial to Evaluate Ketamine-propofol Combination vs. Propofol Alone for Procedural Sedation and Analgesia in the Emergency Department.[NCT01211158] | Phase 3 | 284 participants (Actual) | Interventional | 2010-12-31 | Completed | ||
| Ketofol Versus Fentofol for Procedural Sedation of Children 3 to 17 Years Old: a Double-Blind Randomized Controlled Trial[NCT02079090] | Phase 3 | 30 participants (Actual) | Interventional | 2014-07-31 | Completed | ||
| Comparison of Ketamine Versus Co-Administration of Ketamine and Propofol for Procedural Sedation in a Pediatric Emergency Department[NCT01387139] | Phase 3 | 183 participants (Actual) | Interventional | 2011-01-31 | Completed | ||
| Combination Ketamine and Propofol vs Propofol for Emergency Department Sedation: A Prospective Randomized Trial[NCT01269307] | 99 participants (Actual) | Interventional | 2010-06-30 | Completed | |||
| Ketamine Versus Etomidate for Procedural Sedation for Pediatric Orthopedic Reductions[NCT00596050] | Phase 4 | 50 participants (Actual) | Interventional | 2006-08-31 | Completed | ||
| Systemic Absorption of Lidocaine After Ultrasound Guided Hematoma Block for Reduction of Different Types of Pediatric Distal Radius Fractures[NCT04359017] | Phase 4 | 0 participants (Actual) | Interventional | 2020-11-01 | Withdrawn (stopped due to Sponsoring staff have left institution) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Mean difference in the reduction of the pain scale scores at 20 minutes. Two commonly used, age appropriate and previously validated, pediatric pain assessment tools were used: FACES Pain Scale - Revised for children ages 4-10 and the Visual Analog Scale for children ages 11-17. The FACES Pain Scale - Revised is a self-reported measure of pain intensity developed for children with pain intensity represented by images of grimacing faces on a scale of 0 (no pain) to 10 (maximum pain). The Visual Analog Scale is a self-reported measure of pain intensity where patients mark their pain level on a 10 cm line that represents a continuum of no pain at 0 cm and worst pain at 10 cm. For analysis, pain scale data were merged and reported as values form 0 to 100. The minimum clinically significant reduction in pain was defined as a decrease of 20. (NCT02521415)
Timeframe: 20 minutes
| Intervention | units on a scale (Mean) |
|---|---|
| Ketamine | 44 |
| Fentanyl | 35 |
Compare the total dose of opioid pain medication in morphine equivalents/kg/hour required during the ED evaluation of children with suspected forearm fractures after randomization and treatment with IN ketamine or IN fentanyl. (NCT02521415)
Timeframe: participants will be followed during the emergency department length of stay, estimated to average 6 hours
| Intervention | morphine equivalents/kg/hr (Median) |
|---|---|
| Ketamine | 0.04 |
| Fentanyl | 0.05 |
"Efficacy is defined as:~The patient does not have unpleasant recall of the procedure.~The patient did not experience sedation-related adverse events resulting in abandonment of the procedure or a permanent complication or an unplanned admission to the hospital or prolonged emergency department (ED) observation~The patient did not actively resist or require physical restraint for completion of the procedure. The need for minimal redirection of movements should not be considered as active resistance or physical restraint.~The procedure was successful" (NCT01387139)
Timeframe: After procedure is completed, on average less than 1 hour
| Intervention | participants (Number) |
|---|---|
| Ketamine Alone | 97 |
| Ketamine Co-Administered With Propofol | 81 |
Measured on a 10-point scale (1= least satisfied, 10= most satisfied) (NCT01387139)
Timeframe: After procedure is completed, on average less than 1 hour
| Intervention | units on a scale (Median) |
|---|---|
| Ketamine Alone | 10 |
| Ketamine Co-Administered With Propofol | 8 |
Measured on a 10-point scale (1= least satisfied, 10= most satisfied) (NCT01387139)
Timeframe: After procedure is completed, on average less than 1 hour
| Intervention | units on a scale (1-10) (Median) |
|---|---|
| Ketamine Alone | 10 |
| Ketamine Co-Administered With Propofol | 10 |
Measured on a 10-point scale (1= least satisfied, 10= most satisfied) (NCT01387139)
Timeframe: After procedure is completed, on average less than 1 hour
| Intervention | units on a scale (Median) |
|---|---|
| Ketamine Alone | 9 |
| Ketamine Co-Administered With Propofol | 8 |
Time until the patient has a Vancouver Sedation Recovery Scale Score of 18 or greater. (NCT01387139)
Timeframe: Once Vancouver Sedation Recovery Scale Score reaches 18 or greater, on average less than 1 hour
| Intervention | minutes (Median) |
|---|---|
| Ketamine Alone | 44 |
| Ketamine Co-Administered With Propofol | 43.5 |
We will record all adverse events during the sedation, and then perform a follow-up call to determine if any additional adverse events occured after discharge. (NCT01387139)
Timeframe: From enrollment through completion of follow-up, up to 7 days
| Intervention | participants (Number) | |||
|---|---|---|---|---|
| Respiratory depression | Cardiovascular event | vomiting/retching | Unpleasant recovery reaction | |
| Ketamine Alone | 12 | 1 | 21 | 4 |
| Ketamine Co-Administered With Propofol | 15 | 0 | 18 | 2 |
3 reviews available for ketamine and Bone Fractures
| Article | Year |
|---|---|
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
[Sedation and analgesia in emergency structure. Paediatry: Which sedation and analgesia for the child under spontaneous ventilation?].
Topics: Analgesia; Analgesics; Analgesics, Opioid; Anesthesia, Conduction; Anesthesia, Local; Anesthetics, D | 2012 |
Sedation and analgesia for pediatric fracture reduction in the emergency department: a systematic review.
Topics: Analgesics; Child; Drug Combinations; Emergency Service, Hospital; Fentanyl; Fractures, Bone; Humans | 2006 |
13 trials available for ketamine and Bone Fractures
| Article | Year |
|---|---|
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Randomized Controlled Feasibility Trial of Intranasal Ketamine Compared to Intranasal Fentanyl for Analgesia in Children with Suspected Extremity Fractures.
Topics: Acute Pain; Administration, Intranasal; Adolescent; Analgesics; Arm Injuries; Child; Child, Preschoo | 2017 |
Intranasal ketamine reduces pain of digital nerve block; a double blind randomized clinical trial.
Topics: Administration, Intranasal; Adult; Analgesics; Double-Blind Method; Female; Finger Injuries; Finger | 2019 |
Evaluating the hematoma block as an adjunct to procedural sedation for closed reduction of distal forearm fractures.
Topics: Adolescent; Anesthetics, Local; Child; Child, Preschool; Conscious Sedation; Double-Blind Method; Fe | 2014 |
Etomidate Versus Ketamine: Effective Use in Emergency Procedural Sedation for Pediatric Orthopedic Injuries.
Topics: Adolescent; Child; Deep Sedation; Emergency Service, Hospital; Etomidate; Female; Fentanyl; Fracture | 2016 |
Study protocol of a randomised controlled trial of intranasal ketamine compared with intranasal fentanyl for analgesia in children with suspected, isolated extremity fractures in the paediatric emergency department.
Topics: Administration, Intranasal; Adolescent; Analgesia; Analgesics; Analgesics, Opioid; Child; Child, Pre | 2016 |
Remifentanil combined with low-dose ketamine for postoperative analgesia of lower limb fracture: a double-blind, controlled study.
Topics: Adult; Aged; Analgesia, Patient-Controlled; Double-Blind Method; Female; Fractures, Bone; Humans; Ke | 2009 |
Ketamine/propofol versus midazolam/fentanyl for procedural sedation and analgesia in the emergency department: a randomized, prospective, double-blind trial.
Topics: Adjuvants, Anesthesia; Adult; Analgesics; Anesthetics, Intravenous; Attitude of Health Personnel; Do | 2011 |
Intravenous ketamine is as effective as midazolam/fentanyl for procedural sedation and analgesia in the emergency department.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthetics, Intravenous; Conscious Sedation; Emergency | 2011 |
Comparison of ketamine-low-dose midozolam with midazolam-fentanyl for orthopedic emergencies: a double-blind randomized trial.
Topics: Adolescent; Adult; Aged; Analgesics; Anesthetics, Intravenous; Chi-Square Distribution; Child; Child | 2013 |
Comparison of fentanyl/midazolam with ketamine/midazolam for pediatric orthopedic emergencies.
Topics: Adolescent; Analgesics, Opioid; Anesthetics, Dissociative; Anti-Anxiety Agents; Anxiety; Child; Chil | 1998 |
Comparison of fentanyl/midazolam with ketamine/midazolam for pediatric orthopedic emergencies.
Topics: Adolescent; Analgesics, Opioid; Anesthetics, Dissociative; Anti-Anxiety Agents; Anxiety; Child; Chil | 1998 |
Comparison of fentanyl/midazolam with ketamine/midazolam for pediatric orthopedic emergencies.
Topics: Adolescent; Analgesics, Opioid; Anesthetics, Dissociative; Anti-Anxiety Agents; Anxiety; Child; Chil | 1998 |
Comparison of fentanyl/midazolam with ketamine/midazolam for pediatric orthopedic emergencies.
Topics: Adolescent; Analgesics, Opioid; Anesthetics, Dissociative; Anti-Anxiety Agents; Anxiety; Child; Chil | 1998 |
Comparison of fentanyl/midazolam with ketamine/midazolam for pediatric orthopedic emergencies.
Topics: Adolescent; Analgesics, Opioid; Anesthetics, Dissociative; Anti-Anxiety Agents; Anxiety; Child; Chil | 1998 |
Comparison of fentanyl/midazolam with ketamine/midazolam for pediatric orthopedic emergencies.
Topics: Adolescent; Analgesics, Opioid; Anesthetics, Dissociative; Anti-Anxiety Agents; Anxiety; Child; Chil | 1998 |
Comparison of fentanyl/midazolam with ketamine/midazolam for pediatric orthopedic emergencies.
Topics: Adolescent; Analgesics, Opioid; Anesthetics, Dissociative; Anti-Anxiety Agents; Anxiety; Child; Chil | 1998 |
Comparison of fentanyl/midazolam with ketamine/midazolam for pediatric orthopedic emergencies.
Topics: Adolescent; Analgesics, Opioid; Anesthetics, Dissociative; Anti-Anxiety Agents; Anxiety; Child; Chil | 1998 |
Comparison of fentanyl/midazolam with ketamine/midazolam for pediatric orthopedic emergencies.
Topics: Adolescent; Analgesics, Opioid; Anesthetics, Dissociative; Anti-Anxiety Agents; Anxiety; Child; Chil | 1998 |
Anesthesia with ketamine, propofol, and fentanyl decreases the frequency of postoperative psychosis emergence and confusion in schizophrenic patients.
Topics: Adult; Aged; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Dissociative; Anesthetics, I | 2002 |
Clinical experiences with Ketalar.
Topics: Adolescent; Analgesics; Anesthesia, Conduction; Anesthetics; Child; Child, Preschool; Clinical Trial | 1971 |
21 other studies available for ketamine and Bone Fractures
| Article | Year |
|---|---|
Safety of ketamine for reducing fractures in a pediatric emergency department.
Topics: Analgesics, Opioid; Child; Child, Preschool; Conscious Sedation; Emergency Service, Hospital; Fractu | 2022 |
Removal of percutaneous K-wires used in paediatric fracture stabilisation under IV sedation: a cost-effective and timesaving service delivery in the COVID-19 pandemic setting.
Topics: Administration, Intravenous; Age Factors; Anesthesia, General; Betacoronavirus; Bone Wires; Child; C | 2020 |
A novel rat model of extremity trauma for prehospital pain management research.
Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Emergency Medical Services; Fentanyl; Fibula; F | 2018 |
Higher Mallampati Scores Are Not Associated with More Adverse Events During Pediatric Procedural Sedation and Analgesia.
Topics: Analgesia; Child; Conscious Sedation; Emergency Service, Hospital; Female; Fractures, Bone; Humans; | 2018 |
Use of brachial plexus blockade and medetomidine-ketamine-isoflurane anaesthesia for repair of radio-ulna fracture in an adult cheetah (Acinonyx jubatus).
Topics: Acinonyx; Analgesics; Anesthesia, Conduction; Anesthetics, Inhalation; Animals; Forelimb; Fracture F | 2014 |
Prehospital analgesia with ketamine for combat wounds: a case series.
Topics: Acute Pain; Amputation, Traumatic; Analgesics; Analgesics, Opioid; Benzodiazepines; Emergency Medica | 2014 |
A two-year retrospective review of the determinants of pre-hospital analgesia administration by alpine helicopter emergency medical physicians to patients with isolated limb injury.
Topics: Adult; Air Ambulances; Analgesia; Analgesics; Analgesics, Opioid; Emergency Medical Services; Female | 2016 |
Allergic Reaction to Ketamine as Monotherapy for Procedural Sedation.
Topics: Adolescent; Anesthetics, Dissociative; Conscious Sedation; Diphenhydramine; Drug Eruptions; Emergenc | 2017 |
Alternative analgesics: New drugs for pain seek to improve on ketamine's benefits.
Topics: Analgesics, Non-Narcotic; Animals; Complex Regional Pain Syndromes; Drug Design; Fractures, Bone; Hu | 2017 |
A prospective case series of pediatric procedural sedation and analgesia in the emergency department using single-syringe ketamine-propofol combination (ketofol).
Topics: Adolescent; Analgesics; Anesthetics, Intravenous; Ankle Injuries; Child; Child, Preschool; Conscious | 2010 |
A prospective case series of pediatric procedural sedation and analgesia in the emergency department using single-syringe ketamine-propofol combination (ketofol).
Topics: Adolescent; Analgesics; Anesthetics, Intravenous; Ankle Injuries; Child; Child, Preschool; Conscious | 2010 |
A prospective case series of pediatric procedural sedation and analgesia in the emergency department using single-syringe ketamine-propofol combination (ketofol).
Topics: Adolescent; Analgesics; Anesthetics, Intravenous; Ankle Injuries; Child; Child, Preschool; Conscious | 2010 |
A prospective case series of pediatric procedural sedation and analgesia in the emergency department using single-syringe ketamine-propofol combination (ketofol).
Topics: Adolescent; Analgesics; Anesthetics, Intravenous; Ankle Injuries; Child; Child, Preschool; Conscious | 2010 |
A prospective case series of pediatric procedural sedation and analgesia in the emergency department using single-syringe ketamine-propofol combination (ketofol).
Topics: Adolescent; Analgesics; Anesthetics, Intravenous; Ankle Injuries; Child; Child, Preschool; Conscious | 2010 |
A prospective case series of pediatric procedural sedation and analgesia in the emergency department using single-syringe ketamine-propofol combination (ketofol).
Topics: Adolescent; Analgesics; Anesthetics, Intravenous; Ankle Injuries; Child; Child, Preschool; Conscious | 2010 |
A prospective case series of pediatric procedural sedation and analgesia in the emergency department using single-syringe ketamine-propofol combination (ketofol).
Topics: Adolescent; Analgesics; Anesthetics, Intravenous; Ankle Injuries; Child; Child, Preschool; Conscious | 2010 |
A prospective case series of pediatric procedural sedation and analgesia in the emergency department using single-syringe ketamine-propofol combination (ketofol).
Topics: Adolescent; Analgesics; Anesthetics, Intravenous; Ankle Injuries; Child; Child, Preschool; Conscious | 2010 |
A prospective case series of pediatric procedural sedation and analgesia in the emergency department using single-syringe ketamine-propofol combination (ketofol).
Topics: Adolescent; Analgesics; Anesthetics, Intravenous; Ankle Injuries; Child; Child, Preschool; Conscious | 2010 |
Propofol-ketamine anesthesia for internal fixation of fractures in racehorses.
Topics: Anesthesia, Intravenous; Anesthetics, Dissociative; Anesthetics, Intravenous; Animals; Blood Pressur | 2004 |
Sedation with ketamine: a safe and effective anaesthetic agent for children in the developing world.
Topics: Anesthetics, Dissociative; Child; Child, Preschool; Developing Countries; Female; Fractures, Bone; H | 2003 |
[Intravenous midazolam-ketamine anaesthesia for closed reduction of forearm fractures in children: impact of additional axillary plexus anaesthesia].
Topics: Adolescent; Anesthesia, Intravenous; Anesthetics, Dissociative; Brachial Plexus; Child; Child, Presc | 2006 |
Ketamine-propofol combination sedation for fracture reduction in the pediatric emergency department.
Topics: Adolescent; Anesthetics, Combined; Child; Child, Preschool; Deep Sedation; Emergency Service, Hospit | 2007 |
Ketamine-propofol combination sedation for fracture reduction in the pediatric emergency department.
Topics: Adolescent; Anesthetics, Combined; Child; Child, Preschool; Deep Sedation; Emergency Service, Hospit | 2007 |
Ketamine-propofol combination sedation for fracture reduction in the pediatric emergency department.
Topics: Adolescent; Anesthetics, Combined; Child; Child, Preschool; Deep Sedation; Emergency Service, Hospit | 2007 |
Ketamine-propofol combination sedation for fracture reduction in the pediatric emergency department.
Topics: Adolescent; Anesthetics, Combined; Child; Child, Preschool; Deep Sedation; Emergency Service, Hospit | 2007 |
Ketamine-propofol combination sedation for fracture reduction in the pediatric emergency department.
Topics: Adolescent; Anesthetics, Combined; Child; Child, Preschool; Deep Sedation; Emergency Service, Hospit | 2007 |
Ketamine-propofol combination sedation for fracture reduction in the pediatric emergency department.
Topics: Adolescent; Anesthetics, Combined; Child; Child, Preschool; Deep Sedation; Emergency Service, Hospit | 2007 |
Ketamine-propofol combination sedation for fracture reduction in the pediatric emergency department.
Topics: Adolescent; Anesthetics, Combined; Child; Child, Preschool; Deep Sedation; Emergency Service, Hospit | 2007 |
Ketamine-propofol combination sedation for fracture reduction in the pediatric emergency department.
Topics: Adolescent; Anesthetics, Combined; Child; Child, Preschool; Deep Sedation; Emergency Service, Hospit | 2007 |
Ketamine-propofol combination sedation for fracture reduction in the pediatric emergency department.
Topics: Adolescent; Anesthetics, Combined; Child; Child, Preschool; Deep Sedation; Emergency Service, Hospit | 2007 |
Ketamine-propofol combination sedation for fracture reduction in the pediatric emergency department.
Topics: Adolescent; Anesthetics, Combined; Child; Child, Preschool; Deep Sedation; Emergency Service, Hospit | 2007 |
Ketamine-propofol combination sedation for fracture reduction in the pediatric emergency department.
Topics: Adolescent; Anesthetics, Combined; Child; Child, Preschool; Deep Sedation; Emergency Service, Hospit | 2007 |
Ketamine-propofol combination sedation for fracture reduction in the pediatric emergency department.
Topics: Adolescent; Anesthetics, Combined; Child; Child, Preschool; Deep Sedation; Emergency Service, Hospit | 2007 |
Ketamine-propofol combination sedation for fracture reduction in the pediatric emergency department.
Topics: Adolescent; Anesthetics, Combined; Child; Child, Preschool; Deep Sedation; Emergency Service, Hospit | 2007 |
Ketamine-propofol combination sedation for fracture reduction in the pediatric emergency department.
Topics: Adolescent; Anesthetics, Combined; Child; Child, Preschool; Deep Sedation; Emergency Service, Hospit | 2007 |
Ketamine-propofol combination sedation for fracture reduction in the pediatric emergency department.
Topics: Adolescent; Anesthetics, Combined; Child; Child, Preschool; Deep Sedation; Emergency Service, Hospit | 2007 |
Ketamine-propofol combination sedation for fracture reduction in the pediatric emergency department.
Topics: Adolescent; Anesthetics, Combined; Child; Child, Preschool; Deep Sedation; Emergency Service, Hospit | 2007 |
Clinical perspectives of intravenous ketamine anaesthesia in peafowl (Pavo cristatus).
Topics: Abscess; Anesthesia, Intravenous; Anesthetics, Intravenous; Animals; Bird Diseases; Birds; Dose-Resp | 1996 |
The use of ketamine sedation.
Topics: Analgesics; Anesthetics, Dissociative; Child; Child, Preschool; Conscious Sedation; Emergency Servic | 2000 |
The safety of ketamine sedation in the treatment of traumatic fractures in children.
Topics: Anesthetics, Dissociative; Child; Conscious Sedation; Fractures, Bone; Humans; Hypnotics and Sedativ | 2001 |
[Regional analgesia of the upper extremity in children (author's transl)].
Topics: Adolescent; Anesthesia, Conduction; Anesthesia, General; Arm; Arm Injuries; Axilla; Brachial Plexus; | 1974 |
[Prospects in the clinical use of Ketamine chlorhydrate in pediatric orthopedics and traumatology].
Topics: Adolescent; Age Factors; Child; Child, Preschool; Drug Evaluation; Female; Foot Deformities, Acquire | 1974 |
[Ketamine in orthopedics and traumatology: indications and limits].
Topics: Adolescent; Anesthesia; Cardiovascular System; Child; Child, Preschool; Fractures, Bone; Humans; Inf | 1972 |
Ketamine anesthesia and intranasal or intraoral operations. A potentially dangerous combination.
Topics: Adolescent; Adult; Aged; Airway Obstruction; Anesthesia, Intravenous; Carcinoma, Squamous Cell; Coug | 1973 |