Page last updated: 2024-10-29

ketamine and Circulatory Collapse

ketamine has been researched along with Circulatory Collapse in 22 studies

Ketamine: A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.
ketamine : A member of the class of cyclohexanones in which one of the hydrogens at position 2 is substituted by a 2-chlorophenyl group, while the other is substituted by a methylamino group.

Research Excerpts

ExcerptRelevanceReference
"To investigate the influences of patient-controlled intravenous analgesia (PCIA) with small dose of ketamine solely or combined with fentanyl during shock stage on cytokine balance in patients with severe burn."9.12[Effect of intravenous patient-controlled intravenous analgesia with small dose of ketamine during shock stage on cytokine balance in patients with severe burn]. ( Peng, J; Sun, JB; Xia, JG; Xiao, H; Zhang, J, 2006)
"Our goal was to provide comprehensive data on the effectiveness of ketamine in refractory status epilepticus (RSE) and to describe the potential consequences of long-term ketamine infusion."8.98Potential consequences of high-dose infusion of ketamine for refractory status epilepticus: case reports and systematic literature review. ( Darzi, K; Golub, D; Kaufman, B; Papadopoulos, J; Yanai, A, 2018)
"In our cohort of patients undergoing emergent tracheal intubation, ketamine was used more often for patients with an elevated shock index."8.12Ketamine is not associated with more post-intubation hypotension than etomidate in patients undergoing endotracheal intubation. ( Foster, M; Gelber, A; Hayden, SR; Kennis, B; Lasoff, DR; Self, M; Wardi, G, 2022)
"Ketamine is considered a stable induction agent for rapid sequence induction; however, hypotension rates up to 24% are reported."7.83Hemodynamic Response After Rapid Sequence Induction With Ketamine in Out-of-Hospital Patients at Risk of Shock as Defined by the Shock Index. ( Burns, B; Habig, K; Heldreich, C; Kruit, N; Miller, M; Reid, C; Ware, S, 2016)
"To investigate the influences of patient-controlled intravenous analgesia (PCIA) with small dose of ketamine solely or combined with fentanyl during shock stage on cytokine balance in patients with severe burn."5.12[Effect of intravenous patient-controlled intravenous analgesia with small dose of ketamine during shock stage on cytokine balance in patients with severe burn]. ( Peng, J; Sun, JB; Xia, JG; Xiao, H; Zhang, J, 2006)
"Our goal was to provide comprehensive data on the effectiveness of ketamine in refractory status epilepticus (RSE) and to describe the potential consequences of long-term ketamine infusion."4.98Potential consequences of high-dose infusion of ketamine for refractory status epilepticus: case reports and systematic literature review. ( Darzi, K; Golub, D; Kaufman, B; Papadopoulos, J; Yanai, A, 2018)
"In our cohort of patients undergoing emergent tracheal intubation, ketamine was used more often for patients with an elevated shock index."4.12Ketamine is not associated with more post-intubation hypotension than etomidate in patients undergoing endotracheal intubation. ( Foster, M; Gelber, A; Hayden, SR; Kennis, B; Lasoff, DR; Self, M; Wardi, G, 2022)
"Ketamine is considered a stable induction agent for rapid sequence induction; however, hypotension rates up to 24% are reported."3.83Hemodynamic Response After Rapid Sequence Induction With Ketamine in Out-of-Hospital Patients at Risk of Shock as Defined by the Shock Index. ( Burns, B; Habig, K; Heldreich, C; Kruit, N; Miller, M; Reid, C; Ware, S, 2016)
"Ketamine has been traditionally contra-indicated in the presence of brain injury, but we argue in this review that any adverse effects of the drug on intracranial pressure or cerebral blood flow are in fact attenuated or reversed by controlled ventilation, subsequent anaesthesia and the greater general haemodynamic stability conferred by the drug."2.45Anaesthesia in haemodynamically compromised emergency patients: does ketamine represent the best choice of induction agent? ( Klein, J; Mahoney, P; Morris, C; Perris, A, 2009)
"Propofol was commonly used and is potentially associated with poorer clinical outcomes."1.56Comparison of drugs used for intubation of pediatric trauma patients. ( Davidson, J; Merritt, N; Mudri, M; Priestap, F; Williams, A, 2020)
"Ketamine has been considered the drug of choice for induction in these patients, but limited data exist."1.56Ketamine Use for Tracheal Intubation in Critically Ill Children Is Associated With a Lower Occurrence of Adverse Hemodynamic Events. ( Adu-Darko, M; Al-Subu, AM; Balkandier, S; Branca, A; Breuer, R; Bysani, GK; Conway, JA; Edwards, LR; Emeriaud, G; Esperanza, MC; Furlong-Dillard, J; Giuliano, JS; Harwayne-Gidansky, I; Howell, JD; Ikeyama, T; Jung, P; Kasagi, M; Kharayat, P; Kian Boon, JL; Kirby, A; Krawiec, C; Lee, A; McCarthy, MA; Meyer, K; Nadkarni, VM; Nett, S; Nishisaki, A; Nuthall, G; Orioles, A; Page-Goertz, C; Parsons, SJ; Pinto, M; Polikoff, L; Rehder, KJ; Sanders, RC; Shenoi, A; Shetty, R; Shlomovich, M; Shults, J; Skippen, P; Tallent, S; Tarquinio, KM; Thyagarajan, S; Toedt-Pingel, I; Turner, DA; Vanderford, P; Weiss, SL; Zeqo, J, 2020)
"Ketamine was found to raise the systemic arterial blood pressure but not necessarily the perfusion in hypovolaemic states."1.25The cardiovascular effects of ketamine in hypotensive states. ( Jenkins, LC; Wong, DH, 1975)

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-19909 (40.91)18.7374
1990's4 (18.18)18.2507
2000's4 (18.18)29.6817
2010's2 (9.09)24.3611
2020's3 (13.64)2.80

Authors

AuthorsStudies
Foster, M1
Self, M1
Gelber, A1
Kennis, B1
Lasoff, DR1
Hayden, SR1
Wardi, G1
Mudri, M1
Williams, A1
Priestap, F1
Davidson, J1
Merritt, N1
Conway, JA1
Kharayat, P1
Sanders, RC1
Nett, S1
Weiss, SL1
Edwards, LR1
Breuer, R1
Kirby, A1
Krawiec, C1
Page-Goertz, C1
Polikoff, L1
Turner, DA1
Shults, J1
Giuliano, JS1
Orioles, A1
Balkandier, S1
Emeriaud, G1
Rehder, KJ1
Kian Boon, JL1
Shenoi, A1
Vanderford, P1
Nuthall, G1
Lee, A1
Zeqo, J1
Parsons, SJ1
Furlong-Dillard, J1
Meyer, K1
Harwayne-Gidansky, I1
Jung, P1
Adu-Darko, M1
Bysani, GK1
McCarthy, MA1
Shlomovich, M1
Toedt-Pingel, I1
Branca, A1
Esperanza, MC1
Al-Subu, AM1
Pinto, M1
Tallent, S1
Shetty, R1
Thyagarajan, S1
Ikeyama, T1
Tarquinio, KM1
Skippen, P1
Kasagi, M1
Howell, JD1
Nadkarni, VM1
Nishisaki, A1
Golub, D1
Yanai, A1
Darzi, K1
Papadopoulos, J1
Kaufman, B1
Miller, M1
Kruit, N1
Heldreich, C1
Ware, S1
Habig, K1
Reid, C1
Burns, B1
Morris, C1
Perris, A1
Klein, J1
Mahoney, P1
Kill, C1
Wulf, H1
Kopka, A1
McMenemin, IM1
Serpell, MG1
Quasim, I1
Xia, JG1
Peng, J1
Xiao, H1
Zhang, J1
Sun, JB1
Chen, TS1
Yeh, FC1
Chou, YP1
Chen, HI1
Priano, LL1
Bertin-Maghit, M1
Gueugniaud, PY1
Bouchard, C1
Petit, P1
Busund, R1
Balteskard, L1
Rønning, G1
Høgåsen, K1
Revhaug, A1
Bavister, PH1
Longnecker, DE1
Wong, DH1
Jenkins, LC1
Haskins, SC1
Patz, JD1
Debaene, B1
Goldfarb, G1
Braillon, A1
Jolis, P1
Lebrec, D1
Stoelting, RK1
Patel, S1
Pfenninger, E1
Dick, W1
Ahnefeld, FW1
Wadhwa, RK1
Wadhwa, SR1
Khurana, RC1
Gilston, A1
Davies, C1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Prospective Study of Induction Medications Used in the Rapid Sequence Intubation of Trauma Patients and a Comparison of Effects on Outcomes[NCT04291521]7,000 participants (Anticipated)Observational2024-01-01Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

3 reviews available for ketamine and Circulatory Collapse

ArticleYear
Potential consequences of high-dose infusion of ketamine for refractory status epilepticus: case reports and systematic literature review.
    Anaesthesia and intensive care, 2018, Volume: 46, Issue:5

    Topics: Acidosis; Adult; Electroencephalography; Humans; Infusions, Intravenous; Ketamine; Male; Shock; Stat

2018
Anaesthesia in haemodynamically compromised emergency patients: does ketamine represent the best choice of induction agent?
    Anaesthesia, 2009, Volume: 64, Issue:5

    Topics: Anesthesia, Intravenous; Anesthetics, Dissociative; Emergencies; Evidence-Based Medicine; Hemodynami

2009
Current views on the role of opioid receptors and endorphins in anesthesiology.
    International anesthesiology clinics, 1986,Summer, Volume: 24, Issue:2

    Topics: Acute Disease; Anesthesia; Animals; Blood Circulation; Chronic Disease; Endorphins; Halothane; Human

1986

Trials

1 trial available for ketamine and Circulatory Collapse

ArticleYear
[Effect of intravenous patient-controlled intravenous analgesia with small dose of ketamine during shock stage on cytokine balance in patients with severe burn].
    Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue, 2006, Volume: 18, Issue:1

    Topics: Adult; Analgesia, Patient-Controlled; Burns; Female; Humans; Injections, Intravenous; Interleukin-1;

2006

Other Studies

18 other studies available for ketamine and Circulatory Collapse

ArticleYear
Ketamine is not associated with more post-intubation hypotension than etomidate in patients undergoing endotracheal intubation.
    The American journal of emergency medicine, 2022, Volume: 61

    Topics: Adolescent; Etomidate; Humans; Hypnotics and Sedatives; Hypotension; Intubation, Intratracheal; Keta

2022
Comparison of drugs used for intubation of pediatric trauma patients.
    Journal of pediatric surgery, 2020, Volume: 55, Issue:5

    Topics: Adolescent; Brain Injuries, Traumatic; Child; Child, Preschool; Etomidate; Female; Hospitals, Pediat

2020
Ketamine Use for Tracheal Intubation in Critically Ill Children Is Associated With a Lower Occurrence of Adverse Hemodynamic Events.
    Critical care medicine, 2020, Volume: 48, Issue:6

    Topics: Adolescent; Age Factors; Analgesics; Child; Child, Preschool; Critical Illness; Female; Hemodynamics

2020
Hemodynamic Response After Rapid Sequence Induction With Ketamine in Out-of-Hospital Patients at Risk of Shock as Defined by the Shock Index.
    Annals of emergency medicine, 2016, Volume: 68, Issue:2

    Topics: Adult; Aged; Analgesics; Blood Pressure; Craniocerebral Trauma; Emergency Medical Services; Female;

2016
Emergency care in the new millennium: current developments and perspectives.
    Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS, 2003, Volume: 38, Issue:3

    Topics: Advanced Cardiac Life Support; Emergency Medical Services; Excitatory Amino Acid Antagonists; Guidel

2003
Anaesthesia for cholecystectomy in two non-parturients with Eisenmenger's syndrome.
    Acta anaesthesiologica Scandinavica, 2004, Volume: 48, Issue:6

    Topics: Adult; Analgesics; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intravenous; Cholecyst

2004
Effects of ketamine on the circulatory functions and body tissue oxygenation in dogs under normal and hypovolemic conditions.
    Proceedings of the National Science Council, Republic of China. Part B, Life sciences, 1984, Volume: 8, Issue:2

    Topics: Animals; Blood Pressure; Depression, Chemical; Dogs; Female; Heart Rate; Hemodynamics; Hypotension;

1984
Renal hemodynamic alterations following administration of thiopental, diazepam, or ketamine to conscious hypovolemic dogs.
    Advances in shock research, 1983, Volume: 9

    Topics: Animals; Blood Flow Velocity; Blood Pressure; Diazepam; Dogs; Female; Hemodynamics; Ketamine; Kidney

1983
[Problems caused by anesthesia of patients with severe burns].
    Cahiers d'anesthesiologie, 1995, Volume: 43, Issue:2

    Topics: Anesthesia, General; Anesthetics; Balneology; Burns; Debridement; Humans; Intraoperative Care; Ketam

1995
Fatal myocardial depression and circulatory collapse associated with complement activation induced by plasma infusion in severe porcine sepsis.
    Acta anaesthesiologica Scandinavica, 1995, Volume: 39, Issue:1

    Topics: Albumins; Anesthesia, Inhalation; Animals; Blood Pressure; Blood Transfusion; Calcium; Cardiac Outpu

1995
Influence of anaesthetic agents on the survival of rats following acute ischaemia of the bowel.
    British journal of anaesthesia, 1979, Volume: 51, Issue:10

    Topics: Anesthesia, Inhalation; Anesthesia, Intravenous; Animals; Blood Pressure; Carbon Dioxide; Halothane;

1979
The cardiovascular effects of ketamine in hypotensive states.
    Canadian Anaesthetists' Society journal, 1975, Volume: 22, Issue:3

    Topics: Animals; Blood Pressure; Blood Volume; Cardiac Output; Cats; Heart Rate; Hemodynamics; Hypotension;

1975
Ketamine in hypovolemic dogs.
    Critical care medicine, 1990, Volume: 18, Issue:6

    Topics: Acid-Base Equilibrium; Animals; Carbon Dioxide; Dogs; Hemodynamics; Ketamine; Oxygen; Respiration; S

1990
Effects of ketamine, halothane, enflurane, and isoflurane on systemic and splanchnic hemodynamics in normovolemic and hypovolemic cirrhotic rats.
    Anesthesiology, 1990, Volume: 73, Issue:1

    Topics: Animals; Enflurane; Halothane; Hemodynamics; Infusions, Intravenous; Isoflurane; Ketamine; Liver Cir

1990
Intraoperative therapy for massive blood loss.
    Middle East journal of anaesthesiology, 1986, Volume: 8, Issue:4

    Topics: Adult; Anesthesia, Intravenous; Blood Coagulation Disorders; Blood Transfusion; Fentanyl; Fluid Ther

1986
The influence of ketamine on both normal and raised intracranial pressure of artificially ventilated animals.
    European journal of anaesthesiology, 1985, Volume: 2, Issue:3

    Topics: Animals; Blood Pressure; Female; Heart Rate; Intracranial Pressure; Ketamine; Male; Respiration, Art

1985
Cardiovascular collapse unrelated to anaesthesia. An undiagnosed ectopic pregnancy.
    Anaesthesia, 1974, Volume: 29, Issue:2

    Topics: Adult; Anesthesia, General; Blood Transfusion; Curettage; Dilatation; Female; Humans; Hypotension; K

1974
Letter: Ketamine and pancuronium for the shocked patient.
    Anaesthesia, 1974, Volume: 29, Issue:3

    Topics: Anesthesia, General; Drug Combinations; Humans; Ketamine; Pancuronium; Shock; Surgical Procedures, O

1974