galphimine B: structure given in first source; isolated from the Mexican plant Galphimia glauca, used in traditional medicine [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| Flora | Rank | Flora Definition | Family | Family Definition |
|---|---|---|---|---|
| Galphimia | genus | A plant genus of the family MALPIGHIACEAE. G. glauca is the source of 'Galphimia glauca extract' and contains 'galphimine B' and tetragalloylquinic acid.[MeSH] | Malpighiaceae | A plant family of the order Polygalales, subclass Rosidae class, Magnoliopsida that are mostly shrubs and small trees. Many of the members contain indole alkaloids.[MeSH] |
| Galphimia glauca | species | [no description available] | Malpighiaceae | A plant family of the order Polygalales, subclass Rosidae class, Magnoliopsida that are mostly shrubs and small trees. Many of the members contain indole alkaloids.[MeSH] |
| ID Source | ID |
|---|---|
| PubMed CID | 127671 |
| CHEMBL ID | 523722 |
| MeSH ID | M0224988 |
| Synonym |
|---|
| galphimine b |
| CHEMBL523722 |
| methyl (5as-(5aalpha(s*),7alpha,7aalpha,7bbeta,9abeta,13abeta,13balpha,15abeta,15balpha))-5,5a,6,7,7a,7b,8,9,9a,10,13,13a,14,15,15a,15b-hexadecahydro-7,13a-dihydroxy-5a-(1-hydroxyethyl)-7b,9a,12,15a-tetramethyl-3-oxochryseno(2,1-c)oxepin-13b(3h)-carboxyla |
| chryseno(2,1-c)oxepin-13b(3h)-carboxylic acid, 5,5a,6,7,7a,7b,8,9,9a,10,13,13a,14,15,15a,15b-hexadecahydro-7,13a-dihydroxy-5a-(1-hydroxyethyl)-7b,9a,12,15a-tetramethyl-3-oxo-, methyl ester, (5as-(5aalpha(s*),7alpha,7aalpha,7bbeta,9abeta,13abeta,13balpha,1 |
| d:a-friedo-a-homo-23,24,30-trinor-4-oxaoleana-1,20-dien-27-oic acid, 7,18-dihydroxy-5-(1-hydroxyethyl)-3-oxo-, methyl ester, (5alpha(r),7alpha)- |
| 149199-48-4 |
| methyl 5,5a,6,7,7a,7b,8,9,9a,10,13,13a,14,15,15a,15b-hexadecahydro-7,13a-dihydroxy-5a-(1-hydroxyethyl)-7b,9a,12,15a-tetramethyl-3-oxochryseno(2,1-c)oxepin-13b(3h)-carboxylate (5as-(5aalpha(s*),7alpha,7aalpha,7bbeta,9abeta,13abeta,13balpha,15abeta,15balpha |
| methyl 7,13a-dihydroxy-5a-(1-hydroxyethyl)-7b,9a,12,15a-tetramethyl-3-oxo-5,5a,6,7,7a,7b,8,9,9a,10,13,13a,14,15,15a,15b-hexadecahydrochryseno[2,1-c]oxepine-13b(3h)-carboxylate |
| DTXSID30933574 |
| methyl (1s,2r,5s,10s,11s,14s,15s,21s,23r)-10,23-dihydroxy-21-[(1r)-1-hydroxyethyl]-2,5,8,14-tetramethyl-18-oxo-19-oxapentacyclo[12.9.0.02,11.05,10.015,21]tricosa-7,16-diene-11-carboxylate |
| AKOS040751887 |
Galphimine B is a bioactive compound isolated from the plant Galphimia glauca Cav.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Galphimine B (GB) is a bioactive compound isolated from the plant Galphimia glauca Cav. " | ( Galphimine B modulates synaptic transmission on dopaminergic ventral tegmental area neurons. Prieto-Gómez, B; Reyes-Vázquez, C; Tortoriello, J; Vázquez-Alvarez, A, 2003) | 3.2 |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID378972 | Anxiolytic effect in ICR mouse assessed as increase in time spent on open arm at 15 mg/kg, ip administered 1 hr before by elevated plus-maze test | 2006 | Journal of natural products, Jan, Volume: 69, Issue:1 | Anxiolytic effect of natural galphimines from Galphimia glauca and their chemical derivatives. |
| AID401221 | Cytotoxicity against human HCT15 cells | 2004 | Journal of natural products, Apr, Volume: 67, Issue:4 | Isolation of nor-secofriedelanes from the sedative extracts of Galphimia glauca. |
| AID401222 | Cytotoxicity against human OVCAR cells | 2004 | Journal of natural products, Apr, Volume: 67, Issue:4 | Isolation of nor-secofriedelanes from the sedative extracts of Galphimia glauca. |
| AID401223 | Cytotoxicity against human SQC1 cells | 2004 | Journal of natural products, Apr, Volume: 67, Issue:4 | Isolation of nor-secofriedelanes from the sedative extracts of Galphimia glauca. |
| AID378973 | Anxiolytic effect in ICR mouse assessed as increase in number of entries on open arm at 15 mg/kg, ip administered 1 hr before by elevated plus-maze test | 2006 | Journal of natural products, Jan, Volume: 69, Issue:1 | Anxiolytic effect of natural galphimines from Galphimia glauca and their chemical derivatives. |
| AID401220 | Cytotoxicity against human KB cells | 2004 | Journal of natural products, Apr, Volume: 67, Issue:4 | Isolation of nor-secofriedelanes from the sedative extracts of Galphimia glauca. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (23.08) | 18.2507 |
| 2000's | 7 (53.85) | 29.6817 |
| 2010's | 3 (23.08) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (19.51) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 1 (7.69%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 12 (92.31%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||