galphimine b

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

galphimine B: structure given in first source; isolated from the Mexican plant Galphimia glauca, used in traditional medicine [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Flora	Rank	Flora Definition	Family	Family Definition
Galphimia	genus	A plant genus of the family MALPIGHIACEAE. G. glauca is the source of 'Galphimia glauca extract' and contains 'galphimine B' and tetragalloylquinic acid.[MeSH]	Malpighiaceae	A plant family of the order Polygalales, subclass Rosidae class, Magnoliopsida that are mostly shrubs and small trees. Many of the members contain indole alkaloids.[MeSH]
Galphimia glauca	species	[no description available]	Malpighiaceae	A plant family of the order Polygalales, subclass Rosidae class, Magnoliopsida that are mostly shrubs and small trees. Many of the members contain indole alkaloids.[MeSH]

Cross-References

ID Source	ID
PubMed CID	127671
CHEMBL ID	523722
MeSH ID	M0224988

Synonyms (11)

Synonym
galphimine b
CHEMBL523722
methyl (5as-(5aalpha(s*),7alpha,7aalpha,7bbeta,9abeta,13abeta,13balpha,15abeta,15balpha))-5,5a,6,7,7a,7b,8,9,9a,10,13,13a,14,15,15a,15b-hexadecahydro-7,13a-dihydroxy-5a-(1-hydroxyethyl)-7b,9a,12,15a-tetramethyl-3-oxochryseno(2,1-c)oxepin-13b(3h)-carboxyla
chryseno(2,1-c)oxepin-13b(3h)-carboxylic acid, 5,5a,6,7,7a,7b,8,9,9a,10,13,13a,14,15,15a,15b-hexadecahydro-7,13a-dihydroxy-5a-(1-hydroxyethyl)-7b,9a,12,15a-tetramethyl-3-oxo-, methyl ester, (5as-(5aalpha(s*),7alpha,7aalpha,7bbeta,9abeta,13abeta,13balpha,1
d:a-friedo-a-homo-23,24,30-trinor-4-oxaoleana-1,20-dien-27-oic acid, 7,18-dihydroxy-5-(1-hydroxyethyl)-3-oxo-, methyl ester, (5alpha(r),7alpha)-
149199-48-4
methyl 5,5a,6,7,7a,7b,8,9,9a,10,13,13a,14,15,15a,15b-hexadecahydro-7,13a-dihydroxy-5a-(1-hydroxyethyl)-7b,9a,12,15a-tetramethyl-3-oxochryseno(2,1-c)oxepin-13b(3h)-carboxylate (5as-(5aalpha(s*),7alpha,7aalpha,7bbeta,9abeta,13abeta,13balpha,15abeta,15balpha
methyl 7,13a-dihydroxy-5a-(1-hydroxyethyl)-7b,9a,12,15a-tetramethyl-3-oxo-5,5a,6,7,7a,7b,8,9,9a,10,13,13a,14,15,15a,15b-hexadecahydrochryseno[2,1-c]oxepine-13b(3h)-carboxylate
DTXSID30933574
methyl (1s,2r,5s,10s,11s,14s,15s,21s,23r)-10,23-dihydroxy-21-[(1r)-1-hydroxyethyl]-2,5,8,14-tetramethyl-18-oxo-19-oxapentacyclo[12.9.0.02,11.05,10.015,21]tricosa-7,16-diene-11-carboxylate
AKOS040751887

Research Excerpts

Overview

Galphimine B is a bioactive compound isolated from the plant Galphimia glauca Cav.

Excerpt	Reference	Relevance
"Galphimine B (GB) is a bioactive compound isolated from the plant Galphimia glauca Cav. "	( Galphimine B modulates synaptic transmission on dopaminergic ventral tegmental area neurons. Prieto-Gómez, B; Reyes-Vázquez, C; Tortoriello, J; Vázquez-Alvarez, A, 2003)	3.2

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (6)

Assay ID	Title	Year	Journal	Article
AID378972	Anxiolytic effect in ICR mouse assessed as increase in time spent on open arm at 15 mg/kg, ip administered 1 hr before by elevated plus-maze test	2006	Journal of natural products, Jan, Volume: 69, Issue:1	Anxiolytic effect of natural galphimines from Galphimia glauca and their chemical derivatives.
AID401221	Cytotoxicity against human HCT15 cells	2004	Journal of natural products, Apr, Volume: 67, Issue:4	Isolation of nor-secofriedelanes from the sedative extracts of Galphimia glauca.
AID401222	Cytotoxicity against human OVCAR cells	2004	Journal of natural products, Apr, Volume: 67, Issue:4	Isolation of nor-secofriedelanes from the sedative extracts of Galphimia glauca.
AID401223	Cytotoxicity against human SQC1 cells	2004	Journal of natural products, Apr, Volume: 67, Issue:4	Isolation of nor-secofriedelanes from the sedative extracts of Galphimia glauca.
AID378973	Anxiolytic effect in ICR mouse assessed as increase in number of entries on open arm at 15 mg/kg, ip administered 1 hr before by elevated plus-maze test	2006	Journal of natural products, Jan, Volume: 69, Issue:1	Anxiolytic effect of natural galphimines from Galphimia glauca and their chemical derivatives.
AID401220	Cytotoxicity against human KB cells	2004	Journal of natural products, Apr, Volume: 67, Issue:4	Isolation of nor-secofriedelanes from the sedative extracts of Galphimia glauca.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (13)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	3 (23.08)	18.2507
2000's	7 (53.85)	29.6817
2010's	3 (23.08)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 19.51

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	19.51 (24.57)
Research Supply Index	2.71 (2.92)
Research Growth Index	4.59 (4.65)
Search Engine Demand Index	15.26 (26.88)
Search Engine Supply Index	2.00 (0.95)

This Compound (19.51)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	1 (7.69%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	12 (92.31%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
dimethyl sulfoxide Dimethyl Sulfoxide: A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue during CRYOPRESERVATION. Dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation.. dimethyl sulfoxide : A 2-carbon sulfoxide in which the sulfur atom has two methyl substituents.	2.02	1	0	sulfoxide; volatile organic compound	alkylating agent; antidote; Escherichia coli metabolite; geroprotector; MRI contrast agent; non-narcotic analgesic; polar aprotic solvent; radical scavenger
indoleacetic acid indoleacetic acid: RN given refers to unlabeled parent cpd; structure in Merck Index, 9th ed, #4841. auxin : Any of a group of compounds, both naturally occurring and synthetic, that induce cell elongation in plant stems (from Greek alphaupsilonxialphanuomega, "to grow").. indole-3-acetic acid : A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens has been replaced by a 1H-indol-3-yl group.	2.94	1	0	indole-3-acetic acids; monocarboxylic acid	auxin; human metabolite; mouse metabolite; plant hormone; plant metabolite
alprazolam Alprazolam: A triazolobenzodiazepine compound with antianxiety and sedative-hypnotic actions, that is efficacious in the treatment of PANIC DISORDERS, with or without AGORAPHOBIA, and in generalized ANXIETY DISORDERS. (From AMA Drug Evaluations Annual, 1994, p238). alprazolam : A member of the class of triazolobenzodiazepines that is 4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine carrying methyl, phenyl and chloro substituents at positions 1, 6 and 8 respectively. Alprazolam is only found in individuals that have taken this drug.	4.51	1	1	organochlorine compound; triazolobenzodiazepine	anticonvulsant; anxiolytic drug; GABA agonist; muscle relaxant; sedative; xenobiotic
diazepam Diazepam: A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.. diazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a methyl group at position 1 and a phenyl group at position 5.	2.94	1	0	1,4-benzodiazepinone; organochlorine compound	anticonvulsant; anxiolytic drug; environmental contaminant; sedative; xenobiotic
haloperidol Haloperidol: A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoaffective disorder, DELUSIONAL DISORDERS, ballism, and TOURETTE SYNDROME (a drug of choice) and occasionally as adjunctive therapy in INTELLECTUAL DISABILITY and the chorea of HUNTINGTON DISEASE. It is a potent antiemetic and is used in the treatment of intractable HICCUPS. (From AMA Drug Evaluations Annual, 1994, p279). haloperidol : A compound composed of a central piperidine structure with hydroxy and p-chlorophenyl substituents at position 4 and an N-linked p-fluorobutyrophenone moiety.	3.09	1	0	aromatic ketone; hydroxypiperidine; monochlorobenzenes; organofluorine compound; tertiary alcohol	antidyskinesia agent; antiemetic; dopaminergic antagonist; first generation antipsychotic; serotonergic antagonist
ketamine Ketamine: A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.. ketamine : A member of the class of cyclohexanones in which one of the hydrogens at position 2 is substituted by a 2-chlorophenyl group, while the other is substituted by a methylamino group.	3.09	1	0	cyclohexanones; monochlorobenzenes; secondary amino compound	analgesic; environmental contaminant; intravenous anaesthetic; neurotoxin; NMDA receptor antagonist; xenobiotic
kinetin Kinetin: A furanyl adenine found in PLANTS and FUNGI. It has plant growth regulation effects.. cytokinin : A phytohormone that promote cell division, or cytokinesis, in plant roots and shoots.. kinetin : A member of the class of 6-aminopurines that is adenine carrying a (furan-2-ylmethyl) substituent at the exocyclic amino group.	2.94	1	0	6-aminopurines; furans	cytokinin; geroprotector
galphimine e galphimine E: isolated from the Mexican plant Galphimia glauca; structure in first source	4.1	3	0
galphimine a galphimine A: isolated from the Mexican plant Galphimia glauca; structure in first source	4.33	4	0

Condition	Relationship Strength	Studies	Trials
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.94	1	0
Anochlesia [description not available]	3.09	1	0
Anxiety Neuroses [description not available]	4.51	1	1
Anxiety Disorders Persistent and disabling ANXIETY.	4.51	1	1
Acute Liver Injury, Drug-Induced [description not available]	2.95	1	0
Chemical and Drug Induced Liver Injury A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.	2.95	1	0

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