ketamine has been researched along with Lacerations in 17 studies
Ketamine: A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.
ketamine : A member of the class of cyclohexanones in which one of the hydrogens at position 2 is substituted by a 2-chlorophenyl group, while the other is substituted by a methylamino group.
Lacerations: Torn, ragged, mangled wounds.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study was conducted to determine the effect of intramuscular ondansetron on ketamine-associated vomiting in children undergoing procedural sedation." | 9.34 | Does intramuscular ondansetron have an effect on intramuscular ketamine-associated vomiting in children? A prospective, randomized, double blind, controlled study. ( Akbari, H; Davarani, SS; Hossein, F; Nejati, A; Talebian, MT, 2020) |
| "This study was conducted to determine the effect of intramuscular ondansetron on ketamine-associated vomiting in children undergoing procedural sedation." | 5.34 | Does intramuscular ondansetron have an effect on intramuscular ketamine-associated vomiting in children? A prospective, randomized, double blind, controlled study. ( Akbari, H; Davarani, SS; Hossein, F; Nejati, A; Talebian, MT, 2020) |
| "No difference was found in pain assessment during local anaesthetic injection between the group treated with midazolam and ketamine, and the group treated with midazolam alone." | 5.19 | A double-blind, randomised, placebo-controlled trial of oral midazolam plus oral ketamine for sedation of children during laceration repair. ( Assa, A; Barkan, S; Berkovitch, S; Breitbart, R; Brenner-Zada, G; Feldon, M; Kozer, E; Shavit, I; Toledano, M, 2014) |
| " Nitrous oxide (N(2)O) has the advantages of being a sedative agent that does not require a painful injection and that offers shallower levels of sedation and a rapid recovery of mental state." | 5.16 | A randomized comparison of nitrous oxide versus intravenous ketamine for laceration repair in children. ( Eun, SC; Heo, CY; Jo, YH; Kim, K; Kim, SH; Kim, TY; Lee, JH; Rhee, JE, 2012) |
| "The authors performed a prospective, double-blinded, randomized trial with emergency department (ED) patients requiring procedural sedation and analgesia (PSA) for repair of deep traumatic lacerations and reduction of bone fractures, to compare the ketamine/propofol (ketofol) combination with the midazolam/fentanyl (MF) combination." | 5.15 | Ketamine/propofol versus midazolam/fentanyl for procedural sedation and analgesia in the emergency department: a randomized, prospective, double-blind trial. ( Ashraf, H; Golshani, K; Labaf, A; Moharari, RS; Nejati, A, 2011) |
| "To assess the efficacy and safety of intranasal ketamine at a dose of 6 mg/kg for procedural sedation to repair lacerations with sutures in children in the emergency department." | 4.31 | Intranasal ketamine for procedural sedation in children: An open-label multicenter clinical trial. ( Bailey, B; Desjardins, MP; Finkelstein, Y; Lebel, D; Marquis, C; Rached-d'Astous, S; Trottier, ED, 2023) |
| "Pediatric lacerations are frequently encountered by plastic surgeons in the emergency room." | 1.72 | Effect of sedation using Ketamine for primary closure of pediatric facial laceration. ( Kim, HJ; Kim, JH; Kim, SH; Lee, JH; Shin, SH; Suh, IS; Woo, SS, 2022) |
| "Ketamine is an attractive agent for pediatric procedural sedation." | 1.35 | Pediatric procedural sedation with ketamine: time to discharge after intramuscular versus intravenous administration. ( Babl, FE; Deasy, C; Ramaswamy, P; Sharwood, LN, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (11.76) | 29.6817 |
| 2010's | 9 (52.94) | 24.3611 |
| 2020's | 6 (35.29) | 2.80 |
| Authors | Studies |
|---|---|
| Rached-d'Astous, S | 2 |
| Bailey, B | 2 |
| Marquis, C | 2 |
| Lebel, D | 2 |
| Desjardins, MP | 2 |
| Trottier, ED | 2 |
| Lee, JH | 4 |
| Woo, SS | 1 |
| Shin, SH | 1 |
| Kim, HJ | 1 |
| Kim, JH | 1 |
| Kim, SH | 2 |
| Suh, IS | 1 |
| Finkelstein, Y | 1 |
| Pruc, M | 1 |
| Navolokina, A | 1 |
| Szarpak, L | 1 |
| Nejati, A | 3 |
| Davarani, SS | 1 |
| Talebian, MT | 1 |
| Hossein, F | 1 |
| Akbari, H | 1 |
| Kwon, H | 1 |
| Choi, YJ | 1 |
| Jung, JY | 1 |
| Jalili, M | 1 |
| Abbasi, S | 1 |
| Talebi Sarwari, F | 1 |
| Bidari, A | 1 |
| Ghajarzadeh, M | 1 |
| Akhgar, A | 1 |
| Barkan, S | 2 |
| Breitbart, R | 2 |
| Brenner-Zada, G | 1 |
| Feldon, M | 1 |
| Assa, A | 1 |
| Toledano, M | 2 |
| Berkovitch, S | 2 |
| Shavit, I | 1 |
| Kozer, E | 2 |
| Rubinstein, O | 1 |
| Weiser, G | 1 |
| Karadi, N | 1 |
| Nassi, A | 1 |
| Ramaswamy, P | 1 |
| Babl, FE | 1 |
| Deasy, C | 1 |
| Sharwood, LN | 1 |
| Andolfatto, G | 1 |
| Willman, E | 1 |
| Jameson, E | 1 |
| Moharari, RS | 1 |
| Ashraf, H | 1 |
| Labaf, A | 1 |
| Golshani, K | 1 |
| Kye, YC | 1 |
| Rhee, JE | 2 |
| Kim, K | 2 |
| Kim, T | 1 |
| Jo, YH | 2 |
| Jeong, JH | 1 |
| Tsze, DS | 1 |
| Steele, DW | 1 |
| Machan, JT | 1 |
| Akhlaghi, F | 1 |
| Linakis, JG | 1 |
| Kim, TY | 1 |
| Heo, CY | 1 |
| Eun, SC | 1 |
| Carley, S | 1 |
| Martin, B | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pain Free Laceration Repairs Using Intra-nasal Ketamine: A Dose Escalation Clinical Trial[NCT03053947] | Phase 2 | 42 participants (Actual) | Interventional | 2017-02-16 | Completed | ||
| A Randomized, Clinical Trial of Oral Midazolam Plus Placebo Versus Oral Midazolam Plus Oral Ketamine for Sedation During Laceration Repair[NCT01470157] | Phase 4 | 60 participants (Anticipated) | Interventional | 2011-07-31 | Recruiting | ||
| Comparison Between Efficacy of Ketamine and Propofol Mixture With 1:6 Ratio and 1:4 Ratio for Endoscopic Retrograde Procedure Sedation[NCT03196479] | 58 participants (Actual) | Interventional | 2017-03-01 | Completed | |||
| A Randomized Double-blind Trial to Evaluate Ketamine-propofol Combination vs. Propofol Alone for Procedural Sedation and Analgesia in the Emergency Department.[NCT01211158] | Phase 3 | 284 participants (Actual) | Interventional | 2010-12-31 | Completed | ||
| Ketofol Versus Fentofol for Procedural Sedation of Children 3 to 17 Years Old: a Double-Blind Randomized Controlled Trial[NCT02079090] | Phase 3 | 30 participants (Actual) | Interventional | 2014-07-31 | Completed | ||
| Is Atropine Needed With Ketamine Sedation?[NCT00834470] | Phase 4 | 140 participants (Actual) | Interventional | 2008-08-31 | Completed | ||
| Comparison of Two Methods Using Intranasal Lidocaine to Alleviate Discomfort Associated With Administration of Intranasal Midazolam in Children.[NCT03054844] | Phase 2 | 55 participants (Actual) | Interventional | 2017-04-03 | Completed | ||
| Comparison of Sub-dissociative Intranasal Ketamine Plus Standard Pain Therapy Versus Standard Pain Therapy in the Treatment of Pediatric Sickle Cell Disease Vasoocclusive Crises in Resource-limited Settings: a Multi-centered, Randomized, Controlled Trial[NCT02573714] | 160 participants (Anticipated) | Interventional | 2015-12-31 | Recruiting | |||
| Comparison of N2O Inhalation and Ketamine IV Injection for Sedation in the Treatment of Laceration of Pediatric Patients.[NCT00834730] | Phase 4 | 32 participants (Actual) | Interventional | 2009-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
If my child needed medications to stay calm for a procedure, I would like to use these same medications again. (NCT03054844)
Timeframe: 1 minute
| Intervention | Participants (Count of Participants) |
|---|---|
| PREMED | 10 |
| PREMIX | 12 |
Cry duration was measured in seconds and defined as the time from onset of crying following administration of an IN medication until the cessation of crying sounds and/or tears. If a patient did not cry, the cry duration was zero (NCT03054844)
Timeframe: 10 minutes
| Intervention | seconds (Mean) |
|---|---|
| PREMED | 84 |
| PREMIX | 73 |
The Faces, Legs, Activity, Cry, Consolability (FLACC) scale is comprised of five criteria (face, legs, activity, cry, consolability), with a possible score of 0 to 2 units on a scale for each criteria and a possible total score of 0 to 10 units on a scale (0 meaning no pain, 10 meaning most pain). (NCT03054844)
Timeframe: 10 minutes
| Intervention | Units on a scale (Mean) |
|---|---|
| PREMED | 6.7 |
| PREMIX | 7 |
The Observational Scale of Behavioral Distress-Revised (OSBD-R) is an observational measure of pain and distress shown to have strong validity in children. The scale is an 8-factor, weighted observational scale used to measure distress associated with medical procedures, which has been validated in children and adults aged 1 to 20 years. The total Observational Scale of Behavioral Distress-Revised score is the sum of the scale scores for each phase, with each phase assigned a score from 0 to 23.5 units on a scale (0=no distress, 23.5=maximum distress), based on the frequency and types of behaviors observed during a predetermined number of 15-second intervals during each phase. There were four phases so the range of scores for the total OSBD-R was 0 to 94 units on a scale, with a higher score indicated a greater degree of distress. (NCT03054844)
Timeframe: 10 minutes
| Intervention | Units on a scale (Mean) |
|---|---|
| PREMED | 6.4 |
| PREMIX | 7 |
The Children's Hospital of Eastern Ontario Pain Scale (CHEOPS) utilizes six observational factors (cry, facial, verbal, torso, touch, and legs) to evaluate pain in young children and can be used to monitor the effectiveness of interventions for reducing the pain and discomfort of an intervention. This scale rates each behavior numerically, with a score of 4-6 units on a scale representing no pain, and a maximum score of 13 units on a scale representing (most pain perceived). (NCT03054844)
Timeframe: 10 minutes
| Intervention | Units on a scale (Mean) |
|---|---|
| PREMED | 10.6 |
| PREMIX | 10.5 |
I would like to use this method of administering intranasal midazolam and lidocaine again in the future (NCT03054844)
Timeframe: 1 minute
| Intervention | Participants (Count of Participants) |
|---|---|
| PREMED | 8 |
| PREMIX | 24 |
1 review available for ketamine and Lacerations
| Article | Year |
|---|---|
Question 3 Ketamine or midazolam: does it matter which?
Topics: Child; Conscious Sedation; Evidence-Based Medicine; Forearm Injuries; Humans; Hypnotics and Sedative | 2011 |
10 trials available for ketamine and Lacerations
| Article | Year |
|---|---|
Laceration repair using intranasal ketamine: a phase 2 dose escalation clinical trial.
Topics: Analgesics; Conscious Sedation; Humans; Hypnotics and Sedatives; Ketamine; Lacerations | 2022 |
Does intramuscular ondansetron have an effect on intramuscular ketamine-associated vomiting in children? A prospective, randomized, double blind, controlled study.
Topics: Anesthetics, Dissociative; Antiemetics; Child; Child, Preschool; Closed Fracture Reduction; Consciou | 2020 |
Is ketamine sedation without local anesthesia sufficient for pediatric laceration repair? A double-blind randomized clinical trial.
Topics: Analgesics; Child; Child, Preschool; Double-Blind Method; Emergency Service, Hospital; Female; Human | 2021 |
Intranasal ketamine reduces pain of digital nerve block; a double blind randomized clinical trial.
Topics: Administration, Intranasal; Adult; Analgesics; Double-Blind Method; Female; Finger Injuries; Finger | 2019 |
A double-blind, randomised, placebo-controlled trial of oral midazolam plus oral ketamine for sedation of children during laceration repair.
Topics: Administration, Oral; Anesthetics, Dissociative; Child; Child, Preschool; Conscious Sedation; Double | 2014 |
Efficacy of oral ketamine compared to midazolam for sedation of children undergoing laceration repair: A double-blind, randomized, controlled trial.
Topics: Administration, Oral; Analgesics; Child; Child, Preschool; Conscious Sedation; Double-Blind Method; | 2016 |
Ketamine/propofol versus midazolam/fentanyl for procedural sedation and analgesia in the emergency department: a randomized, prospective, double-blind trial.
Topics: Adjuvants, Anesthesia; Adult; Analgesics; Anesthetics, Intravenous; Attitude of Health Personnel; Do | 2011 |
Clinical effects of adjunctive atropine during ketamine sedation in pediatric emergency patients.
Topics: Adjuvants, Anesthesia; Anesthetics, Dissociative; Atropine; Child, Preschool; Conscious Sedation; Do | 2012 |
Intranasal ketamine for procedural sedation in pediatric laceration repair: a preliminary report.
Topics: Administration, Intranasal; Anesthetics, Dissociative; Child; Child, Preschool; Dose-Response Relati | 2012 |
Intranasal ketamine for procedural sedation in pediatric laceration repair: a preliminary report.
Topics: Administration, Intranasal; Anesthetics, Dissociative; Child; Child, Preschool; Dose-Response Relati | 2012 |
Intranasal ketamine for procedural sedation in pediatric laceration repair: a preliminary report.
Topics: Administration, Intranasal; Anesthetics, Dissociative; Child; Child, Preschool; Dose-Response Relati | 2012 |
Intranasal ketamine for procedural sedation in pediatric laceration repair: a preliminary report.
Topics: Administration, Intranasal; Anesthetics, Dissociative; Child; Child, Preschool; Dose-Response Relati | 2012 |
A randomized comparison of nitrous oxide versus intravenous ketamine for laceration repair in children.
Topics: Administration, Inhalation; Analgesics, Non-Narcotic; Anesthesia Recovery Period; Anesthesia, Inhala | 2012 |
6 other studies available for ketamine and Lacerations
| Article | Year |
|---|---|
Effect of sedation using Ketamine for primary closure of pediatric facial laceration.
Topics: Child; Conscious Sedation; Facial Injuries; Humans; Hypnotics and Sedatives; Infant; Ketamine; Lacer | 2022 |
Intranasal ketamine for procedural sedation in children: An open-label multicenter clinical trial.
Topics: Administration, Intranasal; Analgesics; Child; Conscious Sedation; Emergency Service, Hospital; Huma | 2023 |
Intranasal ketamine for pediatric emergency department lacerations.
Topics: Administration, Intranasal; Analgesics; Child; Double-Blind Method; Emergency Service, Hospital; Fen | 2023 |
Pediatric procedural sedation with ketamine: time to discharge after intramuscular versus intravenous administration.
Topics: Anesthetics, Dissociative; Child, Preschool; Conscious Sedation; Female; Humans; Infant; Injections, | 2009 |
A prospective case series of pediatric procedural sedation and analgesia in the emergency department using single-syringe ketamine-propofol combination (ketofol).
Topics: Adolescent; Analgesics; Anesthetics, Intravenous; Ankle Injuries; Child; Child, Preschool; Conscious | 2010 |
A prospective case series of pediatric procedural sedation and analgesia in the emergency department using single-syringe ketamine-propofol combination (ketofol).
Topics: Adolescent; Analgesics; Anesthetics, Intravenous; Ankle Injuries; Child; Child, Preschool; Conscious | 2010 |
A prospective case series of pediatric procedural sedation and analgesia in the emergency department using single-syringe ketamine-propofol combination (ketofol).
Topics: Adolescent; Analgesics; Anesthetics, Intravenous; Ankle Injuries; Child; Child, Preschool; Conscious | 2010 |
A prospective case series of pediatric procedural sedation and analgesia in the emergency department using single-syringe ketamine-propofol combination (ketofol).
Topics: Adolescent; Analgesics; Anesthetics, Intravenous; Ankle Injuries; Child; Child, Preschool; Conscious | 2010 |
A prospective case series of pediatric procedural sedation and analgesia in the emergency department using single-syringe ketamine-propofol combination (ketofol).
Topics: Adolescent; Analgesics; Anesthetics, Intravenous; Ankle Injuries; Child; Child, Preschool; Conscious | 2010 |
A prospective case series of pediatric procedural sedation and analgesia in the emergency department using single-syringe ketamine-propofol combination (ketofol).
Topics: Adolescent; Analgesics; Anesthetics, Intravenous; Ankle Injuries; Child; Child, Preschool; Conscious | 2010 |
A prospective case series of pediatric procedural sedation and analgesia in the emergency department using single-syringe ketamine-propofol combination (ketofol).
Topics: Adolescent; Analgesics; Anesthetics, Intravenous; Ankle Injuries; Child; Child, Preschool; Conscious | 2010 |
A prospective case series of pediatric procedural sedation and analgesia in the emergency department using single-syringe ketamine-propofol combination (ketofol).
Topics: Adolescent; Analgesics; Anesthetics, Intravenous; Ankle Injuries; Child; Child, Preschool; Conscious | 2010 |
A prospective case series of pediatric procedural sedation and analgesia in the emergency department using single-syringe ketamine-propofol combination (ketofol).
Topics: Adolescent; Analgesics; Anesthetics, Intravenous; Ankle Injuries; Child; Child, Preschool; Conscious | 2010 |
Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary. Midazolam and emergence phenomena in children undergoing ketamine sedation.
Topics: Adolescent; Analgesics; Anti-Anxiety Agents; Child; Child, Preschool; Drug Therapy, Combination; Eme | 2001 |