Glycine Encephalopathy

An autosomal recessive metabolic disorder caused by deficiencies in the mitochondrial GLYCINE cleavage system.

Synonym
Type I Nonketotic Hyperglycinemia
Nonketotic Hyperglycinemia, Type III
Hyperglycinemia, Nonketotic, Type III
Hyperglycinemia, Nonketotic, Type I
Hyperglycinemia, Nonketotic
Nonketotic Hyperglycinemia
Hyperglycinemia, Nonketotic, Type II
Non-ketotic Hyperglycinemia
Nonketotic Hyperglycinemia, Type I
Nonketotic Hyperglycinemia, Type II
Glycine Encephalopathy
Type III Nonketotic Hyperglycinemia
Type II Nonketotic Hyperglycinemia

Excerpt	Reference
"The diagnosis of nonketotic hyperglycinemia is considered to depend upon the presence of increased cerebrospinal fluid glycine and an increased cerebrospinal fluid to plasma glycine ratio."	( Applegarth, DA; Jackson, AH; Kure, S; Levy, HL; Toone, JR, 1999)
"Nonketotic hyperglycinemia is a life-threatening disorder in neonates characterized by a deficiency of the glycine cleavage system."	( Chabrol, B; Confort-Gouny, S; Cozzone, PJ; Nicoli, F; Viola, A; Viout, P, 2002)
"Neonatal nonketotic hyperglycinemia is usually fatal or, less commonly, severely developmentally disabling, whereas transient nonketotic hyperglycinemia has usually been followed by normal development."	( Chugani, D; Chugani, H; Gascon, GG; Hyland, K; Lin, FY, 2006)
"Nonketotic hyperglycinemia is a disorder of amino acid metabolism in which a defect in the glycine cleavage system leads to an accumulation of glycine in the brain and other body compartments."	( Morrison, PF; Sankar, R; Shields, WD, 2006)
"Late-onset nonketotic hyperglycinemia is very rare, presents with varied clinical features, and may be underdiagnosed."	( Carpenter, K; Chiong, MA; Procopis, P; Wilcken, B, 2007)
"Nonketotic hyperglycinemia is an inborn error of glycine metabolism leading to the accumulation of glycine in the brain."	( Cheong, JL; Manley, BJ; Sokol, J, 2010)
"Nonketotic hyperglycinemia is a rare metabolic disorder with severe, frequently fatal, neurologic manifestations."	( Diogo, L; Garcia, P; Grazina, M; Henriques, R; Robalo, C; Simões, M; Veríssimo, C, 2013)
"Nonketotic hyperglycinemia is an inborn error of glycine metabolism."	( Aggarwal, S; Chintakindi, KP; Dalal, AB; Love, DR; Love, JM; Prosser, D, 2014)
"Nonketotic hyperglycinemia is a neurometabolic disorder characterized by intellectual disability, seizures, and spasticity."	( Applegarth, DA; Bjoraker, KJ; Coughlin, CR; Creadon-Swindell, G; Hennermann, JB; Mahieu, V; Matthijs, G; Scharer, GH; Spector, EB; Swanson, MA; Szerlong, HJ; Tong, S; Toone, JR; Van Hove, JL; Williams, K, 2015)
"Nonketotic Hyperglycinemia is an autosomal recessive disorder characterized by defects in the mitochondrial glycine cleavage system."	( Hayes-Rosen, C; Kornitzer, J; Ming, X; Silverstein, S; Veerapandiyan, A, 2019)
"Nonketotic hyperglycinemia is an autosomal recessive inborn error of glycine metabolism, characterized by deficient activity of the glycine cleavage enzyme system."	( Bayrak, H; Ceylaner, S; Kasapkara, ÇS; Kılıç, M; Küçükcongar, A; Olgaç, A; Yıldız, Y; Yüksel, D; Zenciroğlu, A, 2021)

Excerpt	Reference
"Nonketotic hyperglycinemia has variable phenotypic expressions and a poor prognosis."	( Bhamkar, RP; Colaco, P, 2007)

Excerpt	Reference
"Neonatal-type nonketotic hyperglycinemia treatment remains unsatisfactory, even if started early."	( Chien, YH; Chou, SP; Hsu, CC; Huang, A; Hwu, WL; Lee, WT; Lu, FL, 2004)
"Three of four nonketotic hyperglycinemia patients homozygous for a novel GLDC mutation (A802V) were treated by assisted respiration and/or sodium benzoate with or without ketamine and had transient neonatal or absent symptoms and normal developmental outcome, despite persisting biochemical evidence of nonketotic hyperglycinemia."	( Boneh, A; Ergaz, Z; Gomori, JM; Gutman, A; Ichinohe, A; Kojima, K; Korman, SH; Kure, S; Sato, K, 2004)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	3 (2.80)	12.5806
2000's	46 (42.99)	18.1394
2010's	44 (41.12)	28.8240
2020's	14 (13.08)	9.53

Drug	Relationship Strength	Studies	Trials
gamma-aminobutyric acid	low	1	0
benzoic acid	low	2	0
formic acid	low	1	0
carnitine	low	1	0
choline	low	2	0
methylmalonic acid	low	2	0
creatine	low	2	0
formaldehyde	low	1	0
glycine	medium	76	0
glyceric acid	low	1	0
lipoamide	low	1	0
thioctic acid	low	1	0
inositol	low	1	0
melatonin	low	1	0
nitrous oxide	low	1	0
pyridoxal phosphate	low	1	0
pyridoxine	low	1	0
acetaminophen	low	1	0
diazepam	low	1	0
valproic acid	low	5	0
hydralazine	low	1	0
imipramine	medium	1	1
ketamine	low	3	0
apnea	low	3	0
phenobarbital	low	1	0
pirenzepine	low	1	0
propofol	low	1	0
vigabatrin	low	1	0
serine	low	1	0
aspartic acid	low	3	0
glutamine	low	1	0
tyrosine	low	1	0
methionine	low	1	0
asparagine	low	1	0
histidine	low	1	0
threonine	low	2	0
tryptophan	medium	1	1
arginine	low	1	0
glycinaldehyde	low	1	0
tocopherols	low	1	0
glutamic acid	low	2	0
n-acetylaspartic acid	low	3	0
5-bromo-4-chloro-3-indolyl beta-galactoside	low	1	0
homocysteine	low	1	0
phenyldiazene	low	1	0
3-nitrotyrosine	low	1	0
tricaine	low	1	0
lithium chloride	low	1	0
sodium benzoate	low	12	0
dextromethorphan	low	9	0
dizocilpine maleate	low	2	0
aminomethyltransferase	low	16	0
perampanel	low	1	0
levoleucovorin	low	1	0
sapropterin	low	1	0
folic acid	low	2	0
olanzapine	low	1	0

Protein Targets (728)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, Putative fructose-1,6-bisphosphate aldolase	3	0	0	3
Chain A, JmjC domain-containing histone demethylation protein 3A	3	0	0	3
phosphopantetheinyl transferase	8	0	0	8
bromodomain adjacent to zinc finger domain 2B	5	0	0	5
euchromatic histone-lysine N-methyltransferase 2	21	0	0	21
pyruvate kinase PKM isoform a	1	0	0	1
geminin	11	0	0	11
Glycoprotein hormones alpha chain	1	0	0	1
Guanine nucleotide-binding protein G	2	0	0	2
Tubulin--tyrosine ligase	0	2	0	2
RAR-related orphan receptor gamma	5	0	0	5
ATAD5 protein, partial	8	0	0	8
GLS protein	10	0	0	10
Microtubule-associated protein tau	5	0	0	5
Smad3	1	0	0	1
aldehyde dehydrogenase 1 family, member A1	9	0	0	9
thyroid stimulating hormone receptor	11	0	0	11
nuclear receptor subfamily 1, group I, member 3	8	0	0	8
progesterone receptor	4	0	0	4
EWS/FLI fusion protein	3	0	0	3
retinoic acid nuclear receptor alpha variant 1	10	0	0	10
retinoid X nuclear receptor alpha	3	0	0	3
estrogen-related nuclear receptor alpha	9	0	0	9
estrogen nuclear receptor alpha	14	0	0	14
peroxisome proliferator activated receptor gamma	6	0	0	6
aryl hydrocarbon receptor	5	0	0	5
chromobox protein homolog 1	7	0	0	7
thyroid hormone receptor beta isoform 2	8	0	0	8
peripheral myelin protein 22	6	0	0	6
cytochrome P450 3A4 isoform 1	7	0	0	7
Gamma-aminobutyric acid receptor subunit pi	7	6	2	15
ATP-binding cassette sub-family C member 3	0	8	0	8
Multidrug resistance-associated protein 4	0	8	0	9
Solute carrier family 22 member 6	0	1	0	1
Carbonic anhydrase 12	0	1	0	4
UDP-glucuronosyltransferase 1A9	0	0	0	3
Bile salt export pump	0	4	0	4
Voltage-dependent calcium channel gamma-2 subunit	3	0	0	3
Bile salt export pump	0	15	0	15
Cytochrome P450 2B1	0	0	0	1
Cytochrome P450 1A1	0	0	0	1
Carbonic anhydrase 1	0	3	0	11
Carbonic anhydrase 2	0	3	0	11
Myoglobin	0	1	0	1
Cytochrome P450 1A1	0	1	1	3
Cytochrome P450 1A2	0	1	0	3
Prostaglandin G/H synthase 1	0	2	0	2
Carbonic anhydrase 3	0	1	0	4
Cytochrome P450 3A4	0	3	0	6
Cytochrome P450 2D6	0	4	0	6
Cytochrome P450 2C9	0	4	0	5
Polyunsaturated fatty acid lipoxygenase ALOX15	0	4	0	4
Gamma-aminobutyric acid receptor subunit beta-1	7	6	2	15
Sulfotransferase 1A1	0	0	0	1
Gamma-aminobutyric acid receptor subunit delta	7	6	2	15
Gamma-aminobutyric acid receptor subunit gamma-2	7	6	3	16
UDP-glucuronosyltransferase 1-6	0	0	0	2
Glutamate receptor 2	4	2	1	7
Gamma-aminobutyric acid receptor subunit alpha-5	7	6	2	15
Gamma-aminobutyric acid receptor subunit alpha-3	7	6	2	15
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	0	0	1
Carbonic anhydrase 4	0	2	0	5
Prostaglandin G/H synthase 1	0	2	0	2
Carbonic anhydrase 6	0	1	0	4
Gamma-aminobutyric acid receptor subunit gamma-1	7	6	2	15
Gamma-aminobutyric acid receptor subunit alpha-2	7	6	2	15
Gamma-aminobutyric acid receptor subunit alpha-4	7	6	2	15
Gamma-aminobutyric acid receptor subunit gamma-3	7	6	2	15
Gamma-aminobutyric acid receptor subunit alpha-6	7	6	2	15
Carbonic anhydrase 5A, mitochondrial	0	2	0	5
Prostaglandin G/H synthase 2	0	0	0	1
Carbonic anhydrase 7	0	1	0	4
Nuclear receptor ROR-gamma	4	0	0	4
Cytochrome P450 2J2	0	4	0	5
Gamma-aminobutyric acid receptor subunit alpha-1	7	6	3	16
Gamma-aminobutyric acid receptor subunit beta-3	7	6	2	15
Gamma-aminobutyric acid receptor subunit beta-2	7	6	3	16
Carbonic anhydrase 9	0	2	0	5
GABA theta subunit	7	6	2	15
Canalicular multispecific organic anion transporter 1	0	7	0	7
Carbonic anhydrase 15	0	1	0	4
Carbonic anhydrase 13	0	1	0	3
Gamma-aminobutyric acid receptor subunit epsilon	7	6	2	15
Carbonic anhydrase 14	0	1	0	4
Carbonic anhydrase 5B, mitochondrial	0	1	0	4
toxin B	0	0	0	1
thioredoxin reductase	10	0	0	10
TDP1 protein	8	0	0	8
arylsulfatase A	8	0	0	8
Bloom syndrome protein isoform 1	10	0	0	10
D(1A) dopamine receptor	8	0	0	8
lamin isoform A-delta10	14	0	0	14
neuropeptide S receptor isoform A	2	0	0	2
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	6	0	0	6
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
NFKB1 protein, partial	2	0	0	2
alpha-galactosidase	2	0	0	2
cytochrome P450 2C19 precursor	3	0	0	3
flap endonuclease 1	5	0	0	5
DNA polymerase iota isoform a (long)	6	0	0	6
muscarinic acetylcholine receptor M1	11	0	0	11
lethal factor (plasmid)	5	0	0	5
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	0	1	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	0	0	1
Nitric oxide synthase, inducible	0	0	1	3
Cationic amino acid transporter 3	0	1	0	1
ATP-dependent phosphofructokinase	10	0	0	10
Neutral amino acid transporter A	0	3	0	3
Neutral amino acid transporter B(0)	0	3	0	3
Carbonic anhydrase-like protein, putative	0	0	0	7
Amino acid transporter	0	3	0	3
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	6	0	0	6
Chain A, Ferritin light chain	4	0	0	4
Metabotropic glutamate receptor 6	0	1	2	4
Excitatory amino acid transporter 4	0	2	0	2
Glutamate transporter homolog	0	0	1	1
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	0	1	0	1
5-hydroxytryptamine receptor 1D	0	0	0	2
Glutamate receptor ionotropic, NMDA 1	0	10	2	15
Excitatory amino acid transporter 1	0	3	0	4
Excitatory amino acid transporter 2	0	3	0	4
Excitatory amino acid transporter 3	0	3	0	4
Glutamate receptor ionotropic, NMDA 2A	0	10	2	15
Glutamate receptor ionotropic, NMDA 2B	0	10	2	15
Glutamate receptor ionotropic, NMDA 2C	0	10	2	15
Metabotropic glutamate receptor 1	0	1	2	4
Metabotropic glutamate receptor 2	0	1	2	4
Glutamate receptor ionotropic, NMDA 2D	0	10	2	15
Glutamate receptor ionotropic, NMDA 3B	0	10	2	15
Carbonic anhydrase 4	0	0	0	2
Glutamate receptor ionotropic, NMDA 3A	0	10	2	15
Chain A, Oxygen-insensitive Nad(p)h Nitroreductase	0	1	0	1
Chain B, Oxygen-insensitive Nad(p)h Nitroreductase	0	1	0	1
Luciferase	4	0	0	4
acetylcholinesterase	3	0	0	3
GLI family zinc finger 3	9	0	0	9
estrogen receptor 2 (ER beta)	3	0	0	3
Polyphenol oxidase 2	0	1	0	2
D-amino-acid oxidase	0	0	1	1
Cellular tumor antigen p53	11	0	0	11
Neuronal acetylcholine receptor subunit alpha-4	0	3	0	3
Neuronal acetylcholine receptor subunit beta-2	0	3	0	3
Tyrosinase	0	1	0	1
D-amino-acid oxidase	0	2	1	3
Metabotropic glutamate receptor 5	0	1	2	4
Alpha-glucosidase MAL12	0	1	0	1
Monocarboxylate transporter 1	0	0	0	1
Beta-lactamase	0	1	1	2
Nicotinate phosphoribosyltransferase	0	1	0	1
Solute carrier family 22 member 20	0	2	0	2
Solute carrier family 22 member 6	0	2	0	2
D-aspartate oxidase	0	1	0	1
Serine racemase	0	2	0	2
Solute carrier family 22 member 5	0	0	0	1
Solute carrier family 22 member 5	0	0	0	1
Solute carrier family 22 member 16	0	0	0	1
Solute carrier family 22 member 21	0	0	0	1
Solute carrier family 22 member 5	0	0	0	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Putative Glycine Betaine-binding Abc Transporter Protein	0	0	1	1
Chain A, PUTATIVE GLYCINE BETAINE-BINDING ABC TRANSPORTER PROTEIN	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Choline-binding protein	0	0	1	1
Solute carrier family 22 member 1	0	1	0	2
Solute carrier family 22 member 2	0	1	0	2
Solute carrier family 22 member 1	0	2	0	3
Solute carrier family 22 member 2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-3	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-2	0	1	0	1
Neuronal acetylcholine receptor subunit beta-3	0	1	0	1
Neuronal acetylcholine receptor subunit beta-4	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-5	0	1	0	1
Acetylcholinesterase	0	3	0	3
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Choline O-acetyltransferase	0	0	0	1
Neuronal acetylcholine receptor subunit alpha-6	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-9	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	2	0	2
Solute carrier family 22 member 1	0	2	0	3
High affinity choline transporter 1	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-10	0	1	0	1
Solute carrier family 22 member 2	0	2	0	3
Chain A, HADH2 protein	5	0	0	5
Chain B, HADH2 protein	5	0	0	5
5-hydroxytryptamine receptor 3E	0	2	0	2
hypoxia-inducible factor 1 alpha subunit	1	0	0	1
Fumarate hydratase	1	0	0	1
AR protein	11	0	0	11
caspase 7, apoptosis-related cysteine protease	3	0	0	3
cytochrome P450 family 3 subfamily A polypeptide 4	5	0	0	5
glucocorticoid receptor [Homo sapiens]	5	0	0	5
G	4	0	0	4
cytochrome P450 2D6	2	0	0	2
polyprotein	1	0	0	1
Beta-1 adrenergic receptor	0	1	0	1
glucocerebrosidase	2	0	0	2
peroxisome proliferator-activated receptor delta	3	0	0	3
vitamin D (1,25- dihydroxyvitamin D3) receptor	3	0	0	3
caspase-3	3	0	0	3
IDH1	1	0	0	1
Adenylate cyclase type 1	0	1	0	1
Histone H2A.x	2	0	0	2
cytochrome P450 2D6 isoform 1	6	0	0	6
peripheral myelin protein 22 isoform 1	4	0	0	4
cytochrome P450 2C9 precursor	1	0	0	1
potassium voltage-gated channel subfamily H member 2 isoform d	6	0	0	6
DNA polymerase beta	3	0	0	3
mitogen-activated protein kinase 1	2	0	0	2
atrial natriuretic peptide receptor 2 precursor	2	0	0	2
nuclear factor erythroid 2-related factor 2 isoform 1	5	0	0	5
nuclear receptor ROR-gamma isoform 1	3	0	0	3
short transient receptor potential channel 6 isoform 1	0	0	1	1
survival motor neuron protein isoform d	2	0	0	2
M-phase phosphoprotein 8	3	0	0	3
transient receptor potential cation channel subfamily V member 1	1	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	2	0	0	2
Voltage-dependent L-type calcium channel subunit alpha-1F	0	3	0	3
5-hydroxytryptamine receptor 3A	0	1	0	1
5-hydroxytryptamine receptor 4	0	6	0	6
5-hydroxytryptamine receptor 3B	0	2	0	2
Interferon beta	4	0	0	4
HLA class I histocompatibility antigen, B alpha chain	4	0	0	4
Albumin	0	0	2	2
Aldo-keto reductase family 1 member B1	0	5	0	5
Muscarinic acetylcholine receptor M2	0	5	1	6
Muscarinic acetylcholine receptor M4	0	6	1	7
ATP-dependent translocase ABCB1	0	0	0	3
Muscarinic acetylcholine receptor M1	0	4	0	4
Muscarinic acetylcholine receptor M3	0	4	0	4
Muscarinic acetylcholine receptor M4	0	4	0	4
5-hydroxytryptamine receptor 1A	0	4	1	5
5-hydroxytryptamine receptor 2C	0	6	0	6
Muscarinic acetylcholine receptor M5	0	5	0	5
Muscarinic acetylcholine receptor M5	0	6	0	6
Alpha-2A adrenergic receptor	0	4	0	4
Calmodulin-1	0	1	0	1
Beta-2 adrenergic receptor	0	2	0	2
Muscarinic acetylcholine receptor M2	0	5	0	5
Muscarinic acetylcholine receptor M1	0	5	3	9
Angiotensin-converting enzyme	0	3	0	3
D(2) dopamine receptor	0	6	0	9
5-hydroxytryptamine receptor 2A	0	6	0	6
Alpha-1B adrenergic receptor	0	5	1	6
Alpha-2B adrenergic receptor	0	4	0	4
Beta-1 adrenergic receptor	0	1	0	1
Alpha-2C adrenergic receptor	0	4	0	4
D	0	4	0	4
D(3) dopamine receptor	0	4	0	4
5-hydroxytryptamine receptor 1A	0	7	1	8
Alpha-2B adrenergic receptor	0	5	1	6
D(2) dopamine receptor	0	2	0	2
Muscarinic acetylcholine receptor M3	0	6	1	7
Endothelin receptor type B	0	1	0	1
D(1A) dopamine receptor	0	4	0	5
D(4) dopamine receptor	0	4	0	6
D(1B) dopamine receptor	0	1	0	2
Adenylate cyclase type 3	0	1	0	1
Alpha-2C adrenergic receptor	0	5	1	6
UDP-glucuronosyltransferase 1A4	0	0	0	3
Alpha-2A adrenergic receptor	0	5	1	6
Alpha-1D adrenergic receptor	0	5	1	6
Sodium-dependent noradrenaline transporter	0	7	0	7
Sodium-dependent dopamine transporter	0	3	0	3
5-hydroxytryptamine receptor 3A	0	1	0	1
Endothelin receptor type B	0	1	0	1
Histamine H2 receptor	0	2	0	2
Adenosine receptor A1	0	2	0	4
Alpha-1D adrenergic receptor	0	4	0	4
D(1B) dopamine receptor	0	3	0	3
Beta-3 adrenergic receptor	0	1	0	1
Adenylate cyclase type 2	0	1	0	1
Adenylate cyclase type 4	0	1	0	1
5-hydroxytryptamine receptor 2A	0	6	0	8
5-hydroxytryptamine receptor 2C	0	7	1	8
5-hydroxytryptamine receptor 1B	0	3	0	3
5-hydroxytryptamine receptor 1D	0	3	0	3
D(4) dopamine receptor	0	4	0	4
5-hydroxytryptamine receptor 1F	0	3	0	3
5-hydroxytryptamine receptor 2B	0	6	1	7
Histamine H1 receptor	0	2	0	2
Histamine H1 receptor	0	3	0	3
Sodium-dependent serotonin transporter	0	8	0	8
Sodium-dependent serotonin transporter	0	3	0	3
5-hydroxytryptamine receptor 7	0	2	0	2
Cytochrome P450 2C19	0	0	0	2
5-hydroxytryptamine receptor 2C	0	2	0	2
5-hydroxytryptamine receptor 7	0	3	0	3
Alpha-1A adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 2A	0	1	0	1
Histamine H1 receptor	0	6	3	11
Alpha-1B adrenergic receptor	0	2	0	2
D(3) dopamine receptor	0	4	0	6
5-hydroxytryptamine receptor 3A	0	2	0	2
Adenylate cyclase type 8	0	1	0	1
5-hydroxytryptamine receptor 2B	0	6	1	7
Alpha-1A adrenergic receptor	0	6	1	7
5-hydroxytryptamine receptor 3A	0	2	0	2
Histamine H2 receptor	2	1	0	3
5-hydroxytryptamine receptor 5A	0	1	0	1
5-hydroxytryptamine receptor 6	0	5	0	6
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	2	0	2
D(2) dopamine receptor	0	1	0	1
D(3) dopamine receptor	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
Spike glycoprotein	4	0	0	4
D(2) dopamine receptor	0	2	0	2
D(2) dopamine receptor	0	5	0	5
Calmodulin	0	0	1	1
Inositol monophosphatase 1	3	0	0	3
Voltage-dependent L-type calcium channel subunit alpha-1D	0	3	0	3
Sodium-dependent dopamine transporter	0	2	0	2
5-hydroxytryptamine receptor 2B	0	1	0	1
Adenylate cyclase type 6	0	1	0	1
Adenylate cyclase type 5	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	6	0	6
5-hydroxytryptamine receptor 4	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1C	0	3	0	3
Transporter	0	2	0	2
Cholecystokinin receptor type A	0	1	0	1
5-hydroxytryptamine receptor 1A	0	1	0	1
Nuclear receptor subfamily 3 group C member 3	0	3	0	3
5-hydroxytryptamine receptor 3D	0	2	0	2
Adenylyl cyclase 7	0	1	0	1
5-hydroxytryptamine receptor 3C	0	2	0	2
Inositol hexakisphosphate kinase 1	4	0	0	4
D	0	2	0	2
ATPase family AAA domain-containing protein 5	3	0	0	3
Ataxin-2	5	0	0	5
Sigma non-opioid intracellular receptor 1	0	2	0	2
Histamine H4 receptor	0	1	1	2
5-hydroxytryptamine receptor 3B	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	3	0	3
Transporter	0	4	0	4
Histamine H3 receptor	0	2	0	2
cytochrome P450 2C9, partial	4	0	0	4
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Proton-coupled amino acid transporter 1	0	4	0	4
Glutamate receptor ionotropic, NMDA 2D	0	3	0	3
Glutamate receptor ionotropic, NMDA 3B	0	3	0	3
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Cytochrome P450 2D1	0	1	0	1
Cytochrome P450 2D26	0	1	0	1
Cytochrome P450 2D3	0	1	0	1
Taste receptor type 2 member 46	0	0	1	1
Glutamate receptor ionotropic, NMDA 1	0	4	0	4
Glutamate receptor ionotropic, NMDA 2A	0	4	0	4
Glutamate receptor ionotropic, NMDA 2B	0	4	0	4
Glutamate receptor ionotropic, NMDA 2C	0	3	0	3
Sigma non-opioid intracellular receptor 1	0	4	0	4
Cytochrome P450 2D4	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	3	0	3
Gamma-aminobutyric acid	0	1	1	2
glp-1 receptor, partial	3	0	0	3
pregnane X nuclear receptor	6	0	0	6
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	5	0	0	5
Gamma-aminobutyric acid receptor subunit pi	0	3	0	3
Gamma-aminobutyric acid receptor subunit delta	0	3	0	3
Fatty acid-binding protein, liver	0	1	0	1
Alpha-1-acid glycoprotein 1	0	0	0	1
Albumin	0	0	1	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	0	3
Gamma-aminobutyric acid receptor subunit beta-1	0	2	0	3
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	0	3
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	0	3
Gamma-aminobutyric acid receptor subunit alpha-1	0	4	4	8
Translocator protein	0	1	1	3
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-1	0	3	2	5
Gamma-aminobutyric acid receptor subunit gamma-2	0	4	3	7
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	0	3
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	0	3
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit delta	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-3	0	4	3	7
Translocator protein	0	1	0	1
Translocator protein	0	1	0	1
Cholecystokinin receptor type A	1	1	0	2
Gastrin/cholecystokinin type B receptor	1	1	0	2
Gamma-aminobutyric acid receptor subunit alpha-5	0	3	4	7
Gamma-aminobutyric acid receptor subunit alpha-3	0	3	3	6
Gamma-aminobutyric acid receptor subunit alpha-2	0	3	3	6
Gamma-aminobutyric acid receptor subunit beta-2	0	3	3	6
Gamma-aminobutyric acid receptor subunit alpha-4	0	3	2	5
Gamma-aminobutyric acid receptor subunit beta-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit epsilon	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-6	0	3	2	5
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-1	0	3	0	3
Gamma-aminobutyric acid receptor subunit pi	0	1	1	2
Sphingosine-1-phosphate lyase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	1	2
Gamma-aminobutyric acid receptor subunit theta	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit theta	0	3	0	3
Chain A, Dihydrofolate reductase	0	0	1	1
Chain A, 2-oxoglutarate Oxygenase	6	0	0	6
acid sphingomyelinase	1	0	0	1
USP1 protein, partial	4	0	0	4
activating transcription factor 6	5	0	0	5
lysosomal alpha-glucosidase preproprotein	2	0	0	2
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	4	0	0	4
nuclear factor erythroid 2-related factor 2 isoform 2	3	0	0	3
Thymidylate synthase	0	2	0	2
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	0	1	1
Aldo-keto reductase family 1 member B1	0	3	0	3
Alpha-synuclein	1	0	0	1
Folylpolyglutamate synthase, mitochondrial	0	0	0	1
Solute carrier organic anion transporter family member 1A3	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	0	0	1
Multidrug resistance associated protein	0	0	0	1
Gamma-aminobutyric acid receptor subunit rho-3	0	0	1	1
Hsf1 protein	0	0	1	1
regulator of G-protein signaling 4	5	0	0	5
thyroid hormone receptor beta isoform a	3	0	0	3
transcriptional regulator ERG isoform 3	2	0	0	2
histone-lysine N-methyltransferase 2A isoform 2 precursor	4	0	0	4
histone acetyltransferase KAT2A isoform 1	4	0	0	4
Histone deacetylase 3	0	3	0	3
Gamma-aminobutyric acid type B receptor subunit 2	0	1	1	2
Gamma-aminobutyric acid type B receptor subunit 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 1	0	2	0	2
Gamma-aminobutyric acid receptor subunit rho-1	0	0	2	2
Gamma-aminobutyric acid receptor subunit rho-2	0	0	1	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent taurine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	2	0	2
Sodium- and chloride-dependent GABA transporter 3	0	2	0	2
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	2	0	2
Sodium- and chloride-dependent GABA transporter 3	0	2	0	2
Sodium- and chloride-dependent betaine transporter	0	2	0	2
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Histone deacetylase 4	0	3	0	3
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	2
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	2
TAR DNA-binding protein 43	3	1	0	4
Histone deacetylase 1	0	3	0	3
Sterol O-acyltransferase 1	0	0	1	1
Histone deacetylase 7	0	3	0	3
Histone deacetylase 2	0	3	0	3
Polyamine deacetylase HDAC10	0	3	0	3
Histone deacetylase 11	0	3	0	3
Histone deacetylase 8	0	3	0	3
Platelet glycoprotein VI	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Histone deacetylase 6	0	3	0	3
Gamma-aminobutyric acid type B receptor subunit 1	0	1	1	2
Histone deacetylase 9	0	3	0	3
Histone deacetylase 5	0	3	0	3
Gamma-aminobutyric acid type B receptor subunit 1	0	1	0	1
Chain A, GLUTAMATE RECEPTOR SUBUNIT 2	0	1	0	1
Chain A, Glutamate Receptor Subunit 2	0	1	0	1
Chain B, Glutamate Receptor Subunit 2	0	1	0	1
Chain A, Slr1257 protein	0	0	1	1
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	0	1	0	1
beta-2 adrenergic receptor	1	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	4	0	0	4
Metabotropic glutamate receptor 8	0	2	0	2
Glutathione reductase, mitochondrial	0	2	0	2
Bifunctional aspartokinase/homoserine dehydrogenase 1	0	1	0	1
Prothrombin	0	0	1	1
Integrin beta-3	1	0	1	2
Integrin alpha-IIb	1	0	1	2
ATP-citrate synthase	0	1	0	1
Glutamate receptor 1	1	2	1	4
Glutamate receptor 3	1	2	1	4
Glutamate receptor 4	1	2	1	4
Glutamate receptor ionotropic, kainate 1	0	2	1	3
Metabotropic glutamate receptor 1	0	2	1	3
Metabotropic glutamate receptor 2	0	0	1	1
Metabotropic glutamate receptor 3	0	0	1	1
Metabotropic glutamate receptor 4	0	1	1	2
Metabotropic glutamate receptor 5	0	0	1	1
Metabotropic glutamate receptor 6	0	0	1	1
Metabotropic glutamate receptor 7	0	0	1	1
Glutamate receptor ionotropic, kainate 1	0	1	1	2
Glutamate receptor ionotropic, kainate 2	0	2	1	3
Glutamate receptor 1	0	3	1	4
Glutamate receptor 2	0	2	1	3
Glutamate receptor 3	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	2	0	2
Metabotropic glutamate receptor 8	0	0	1	1
Glutamate receptor 4	0	2	1	3
Excitatory amino acid transporter 3	0	0	0	1
Glutamate racemase	0	0	0	1
Metabotropic glutamate receptor 8	0	1	1	2
Fatty-acid amide hydrolase 1	0	2	0	2
Glutamate receptor ionotropic, kainate 4	0	2	0	2
Glutamate carboxypeptidase 2	0	1	0	1
Glutamate receptor ionotropic, kainate 2	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	1	0	1
Metabotropic glutamate receptor 7	0	1	1	3
Metabotropic glutamate receptor 3	0	1	1	3
Metabotropic glutamate receptor 4	0	1	1	3
Glutamate receptor ionotropic, kainate 5	0	1	0	1
Glutamate receptor ionotropic, kainate 5	0	2	0	2
Glutamate racemase	0	0	0	1
Prolyl 4-hydroxylase	0	1	0	1
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
Chain A, Glutamine Binding Protein	0	0	1	1
15-lipoxygenase, partial	1	0	0	1
Asc-type amino acid transporter 1	0	1	0	1
Glycine receptor subunit alpha-1	0	0	1	1
Sodium- and chloride-dependent glycine transporter 1	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	5	0	5
Olfactory receptor 51E2	0	0	1	1
Sodium- and chloride-dependent glycine transporter 2	0	1	0	1
Chain A, HISTIDINE-BINDING PROTEIN	0	0	1	1
Plasma kallikrein	0	0	0	3
Histidine-binding periplasmic protein	0	0	1	1
Adenosine receptor A2a	0	0	0	2
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase	0	0	0	3
Glutaminyl-peptide cyclotransferase	0	1	0	1
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase	0	1	0	4
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase 13	0	0	0	1
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	1	0	1
Thrombopoietin	1	0	0	1
Parkin	1	0	0	1
pyruvate kinase	1	0	0	1
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
cellular tumor antigen p53 isoform a	1	0	0	1
ras-related protein Rab-9A	2	0	0	2
pyruvate kinase PKM isoform b	1	0	0	1
N-glycosylase/DNA lyase	0	1	0	1
Myeloperoxidase	0	3	0	3
Ornithine decarboxylase	1	0	0	1
Aspartate aminotransferase, cytoplasmic	0	1	0	1
Lactoperoxidase	0	1	0	1
Single-stranded DNA cytosine deaminase	1	0	0	1
Snq2p	0	0	0	1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	2	0	0	2
v-jun sarcoma virus 17 oncogene homolog (avian)	4	0	0	4
serine/threonine-protein kinase mTOR isoform 1	1	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Sodium-dependent noradrenaline transporter	0	1	0	1
Solute carrier family 22 member 3	0	1	0	1
Major prion protein	0	0	1	1
Sphingomyelin phosphodiesterase	0	1	0	1
5-hydroxytryptamine receptor 6	0	1	0	1
Pleiotropic ABC efflux transporter of multiple drugs	0	1	0	2
5-hydroxytryptamine receptor 5A	0	1	0	1
5-hydroxytryptamine receptor 5B	0	1	0	1
Sodium channel protein type 1 subunit alpha	0	2	0	2
Sodium channel protein type 4 subunit alpha	0	2	0	2
UDP-glucuronosyltransferase 1A3	0	0	0	1
D(1A) dopamine receptor	1	0	0	1
5-hydroxytryptamine receptor 7	0	1	0	1
Voltage-dependent N-type calcium channel subunit alpha-1B	0	1	0	1
Sodium channel protein type 7 subunit alpha	0	1	0	1
Envelope glycoprotein	0	0	1	1
Sodium channel protein type 5 subunit alpha	0	1	0	1
Sodium channel protein type 9 subunit alpha	0	1	0	1
Sigma intracellular receptor 2	0	1	0	1
Sodium-dependent serotonin transporter	0	1	0	1
Sodium-dependent dopamine transporter	0	1	0	1
5-hydroxytryptamine receptor 4	0	1	0	1
Multidrug and toxin extrusion protein 2	0	1	0	1
Multidrug and toxin extrusion protein 1	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	2	0	2
Sodium channel protein type 3 subunit alpha	0	2	0	2
Sodium channel protein type 11 subunit alpha	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	1	0	1
Sodium channel protein type 10 subunit alpha	0	1	0	1
Chain B, Pulmonary surfactant-associated protein D	0	1	0	1
Chain A, Pulmonary surfactant-associated protein D	0	1	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
Amyloid-beta precursor protein	0	1	0	1
Sodium/myo-inositol cotransporter 2	0	1	0	1
Acetylcholinesterase	0	2	0	2
Rap guanine nucleotide exchange factor 3	1	0	0	1
Cholinesterase	0	2	0	2
inositol monophosphatase 1	1	0	0	1
Glycogen synthase kinase-3 beta	0	1	1	2
interleukin 8	1	0	0	1
ClpP	1	0	0	1
Cytochrome P450 1A2	0	1	0	1
Cholinesterase	0	2	0	2
Cytochrome P450 2C11	0	1	0	1
Aromatase	0	1	0	1
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	2	0	2
Acetylcholinesterase	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Nociceptin receptor	0	1	0	1
Melatonin receptor type 1A	0	2	1	3
Melatonin receptor type 1C	0	0	1	1
Melatonin receptor type 1A	0	1	1	2
Melatonin receptor type 1B	0	2	1	3
Melatonin receptor type 1C	0	1	1	2
Melatonin receptor type 1B	0	1	1	2
Nuclear factor erythroid 2-related factor 2	0	0	0	1
Cytochrome P450 1B1	0	1	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	1	0	1
Carboxylic ester hydrolase	0	1	0	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Aminopeptidase	0	1	0	1
Chain A, Methionine aminopeptidase	0	1	0	1
S-ribosylhomocysteine lyase	0	1	0	1
Adenylate cyclase type 5	0	0	0	1
S-adenosylmethionine synthase isoform type-1	0	0	0	1
S-adenosylmethionine synthase isoform type-2	0	0	0	1
Fatty acid synthase	0	1	0	1
Chain A, Beta-lactamase	2	0	0	2
importin subunit beta-1 isoform 1	1	0	0	1
snurportin-1	1	0	0	1
tumor susceptibility gene 101 protein	1	0	0	1
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
Serine racemase	0	1	0	1
67.9K protein	1	0	0	1
DNA polymerase kappa isoform 1	3	0	0	3
Rap guanine nucleotide exchange factor 4	1	0	0	1
vitamin D3 receptor isoform VDRA	1	0	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	2	0	0	2
FAD-linked sulfhydryl oxidase ALR	0	0	0	1
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Disintegrin and metalloproteinase domain-containing protein 17	2	0	0	2
Replicase polyprotein 1ab	0	1	0	1
dopamine D1 receptor	1	0	0	1
GALC protein	1	0	0	1
Muscarinic acetylcholine receptor M1	0	1	0	1
Muscarinic acetylcholine receptor DM1	0	1	0	1
Muscarinic acetylcholine receptor M4	0	1	0	1
Muscarinic acetylcholine receptor	0	1	0	1
Muscarinic acetylcholine receptor M5	0	1	0	1
Muscarinic acetylcholine receptor M3	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	2	0	0	2
farnesoid X nuclear receptor	2	0	0	2
heat shock protein beta-1	1	0	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
UDP-glucuronosyltransferase 1A8	0	0	0	1
Receptor-type tyrosine-protein phosphatase beta	0	0	0	1
Low molecular weight phosphotyrosine protein phosphatase	0	1	0	1
P2X purinoceptor 1	0	0	1	1
P2X purinoceptor 1	0	1	0	1
P2X purinoceptor 4	0	0	1	1
Trans-sialidase	0	1	0	1
Trans-sialidase	0	1	0	1
P2X purinoceptor 2	0	0	1	1
Pyridoxal kinase	0	0	0	1
Pyruvate kinase PKM	0	0	1	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	1	0	0	1
Ubiquitin-like modifier activating enzyme 2	0	1	0	1
SMAD family member 2	1	0	0	1
SUMO1 activating enzyme subunit 1	0	1	0	1
SMAD family member 3	1	0	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
hexokinase	0	1	0	1
SUMO-conjugating enzyme UBC9	0	1	0	1
eukaryotic translation initiation factor 4 gamma 1 isoform 4	0	1	0	1
eukaryotic translation initiation factor 4E isoform 1	0	1	0	1
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
Vif	0	1	0	1
Tat	0	1	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	0	1	0	1
bifunctional UDP-N-acetylglucosamine pyrophosphorylase/glucosamine-1-phosphate N-acetyltransferase	0	1	0	1
nuclear receptor subfamily 1, group I, member 2	1	0	0	1
Chain A, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain K, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain B, tryptophanyl-tRNA synthetase	0	0	1	1
Chain C, Tryptophanyl-tRNA synthetase II	0	0	1	1
thioredoxin glutathione reductase	1	0	0	1
thyroid stimulating hormone receptor	1	0	0	1
Dihydrofolate reductase	0	2	0	2
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Stromelysin-1	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	2
Substance-P receptor	0	1	0	1
Tryptophan 2,3-dioxygenase	0	1	0	2
SLC16A10 protein	0	0	0	2
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Tryprostatin B synthase	0	0	0	1
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	0	0	1	1
Monocarboxylate transporter 10	0	0	0	2
Phospholipase A-2-activating protein	0	1	0	1
Chain A, CHORISMATE MUTASE	0	1	0	1
Chain A, TYROSYL-tRNA SYNTHETASE	0	0	1	1
Taste receptor type 2 member 14	0	0	0	1
pregnane X receptor	1	0	0	1
Cocaine esterase	0	1	0	1
Cytochrome P450 2A6	0	1	0	1
Tissue factor	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	1	0	2
Liver carboxylesterase 1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member B7	0	1	0	1
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
endonuclease IV	1	0	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(13)

Research Excerpts

Overview

Context

Treatment

Research

Studies (107)

Protein Targets (728)

Glycine Encephalopathy

Synonyms(13)

Research Excerpts

Overview

Context

Treatment

Research

Studies (107)

Drugs Studied (62)

Protein Targets (728)