ketamine has been researched along with Alcohol Drinking in 27 studies
Ketamine: A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.
ketamine : A member of the class of cyclohexanones in which one of the hydrogens at position 2 is substituted by a 2-chlorophenyl group, while the other is substituted by a methylamino group.
Alcohol Drinking: Behaviors associated with the ingesting of ALCOHOLIC BEVERAGES, including social drinking.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We found that ketamine leads to significantly greater mystical-type effects (by Hood Mysticism Scale) and dissociation (by Clinician Administered Dissociative States Scale) compared to the active control." | 5.41 | Mystical-type experiences occasioned by ketamine mediate its impact on at-risk drinking: Results from a randomized, controlled trial. ( Azhari, N; Dakwar, E; Haug, NA; Rothberg, RL, 2021) |
| "Worldwide, alcohol abuse is a burgeoning problem." | 2.84 | A proof-of-concept investigation into ketamine as a pharmacological treatment for alcohol dependence: study protocol for a randomised controlled trial. ( Brandner, B; Lawn, W; McAndrew, A; Morgan, CJ; Porffy, L; Stevens, T, 2017) |
| "Alcohol use disorder is highly prevalent and has important economical, societal, psychiatric, and medical consequences." | 2.82 | Efficacy of ketamine intervention to decrease alcohol use, cravings, and withdrawal symptoms in adults with problematic alcohol use or alcohol use disorder: A systematic review and comprehensive analysis of mechanism of actions. ( Garel, N; Greenway, KT; Jutras-Aswad, D; Lesperance, P; McAnulty, C; Miron, JP; Rej, S; Richard-Devantoy, S, 2022) |
| "Problematic compounds may cause seizures either acutely or on withdrawal: Their use may reduce effectiveness of antiepileptic drugs, or may simply promote and enhance chaotic lifestyles." | 2.48 | Alcohol and drugs in epilepsy: pathophysiology, presentation, possibilities, and prevention. ( Borland, W; Leach, JP; Mohanraj, R, 2012) |
| "This article summarizes the short-term physiological toxicity and the adverse behavioral effects of four substances (GHB, ketamine, MDMA, and Rohypnol) that have been used at latenight dance clubs." | 2.42 | Acute toxic effects of club drugs. ( Gable, RS, 2004) |
| "Ketamine is a potentially dependence-forming drug." | 1.35 | Attentional bias to incentive stimuli in frequent ketamine users. ( Curran, HV; Morgan, CJ; Rees, H, 2008) |
| "The correlates of polysubstance use were examined using the two-step procedure of variable selection." | 1.34 | Polysubstance use and its correlates in adolescent ecstasy users in Taiwan. ( Cheng, CP; Hsu, SY; Yen, CF, 2007) |
| "Odds ratios (ORs) for association of substance use and UAI during the previous year were adjusted for age and calendar year." | 1.32 | Unprotected anal intercourse associated with recreational drug use among young men who have sex with men depends on partner type and intercourse role. ( Hogg, RS; Lampinen, TM; Rusch, M; Schilder, A, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.70) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 9 (33.33) | 29.6817 |
| 2010's | 11 (40.74) | 24.3611 |
| 2020's | 6 (22.22) | 2.80 |
| Authors | Studies |
|---|---|
| Ardinger, CE | 1 |
| Winkler, G | 1 |
| Lapish, CC | 1 |
| Grahame, NJ | 1 |
| Grabski, M | 1 |
| McAndrew, A | 2 |
| Lawn, W | 2 |
| Marsh, B | 1 |
| Raymen, L | 1 |
| Stevens, T | 2 |
| Hardy, L | 1 |
| Warren, F | 1 |
| Bloomfield, M | 1 |
| Borissova, A | 1 |
| Maschauer, E | 1 |
| Broomby, R | 1 |
| Price, R | 1 |
| Coathup, R | 1 |
| Gilhooly, D | 1 |
| Palmer, E | 1 |
| Gordon-Williams, R | 1 |
| Hill, R | 1 |
| Harris, J | 1 |
| Mollaahmetoglu, OM | 1 |
| Curran, HV | 3 |
| Brandner, B | 3 |
| Lingford-Hughes, A | 1 |
| Morgan, CJA | 1 |
| Garel, N | 1 |
| McAnulty, C | 1 |
| Greenway, KT | 1 |
| Lesperance, P | 1 |
| Miron, JP | 1 |
| Rej, S | 1 |
| Richard-Devantoy, S | 1 |
| Jutras-Aswad, D | 1 |
| Geuens, M | 1 |
| Van Hoofstadt, K | 1 |
| Hoogmartens, O | 1 |
| Van den Eede, N | 1 |
| Sabbe, M | 1 |
| Das, RK | 1 |
| Gale, G | 1 |
| Walsh, K | 1 |
| Hennessy, VE | 1 |
| Iskandar, G | 1 |
| Mordecai, LA | 1 |
| Kindt, M | 1 |
| Kamboj, SK | 1 |
| Costa, YRS | 1 |
| Lavorato, SN | 1 |
| Baldin, JJCMC | 1 |
| Rothberg, RL | 1 |
| Azhari, N | 1 |
| Haug, NA | 1 |
| Dakwar, E | 1 |
| Porffy, L | 1 |
| Morgan, CJ | 2 |
| Ruda-Kucerova, J | 1 |
| Babinska, Z | 1 |
| Luptak, M | 1 |
| Getachew, B | 1 |
| Tizabi, Y | 1 |
| Yoon, G | 1 |
| Petrakis, IL | 2 |
| Krystal, JH | 4 |
| Heifets, BD | 1 |
| Williams, NR | 1 |
| Blasey, C | 1 |
| Sudheimer, K | 1 |
| Rodriguez, CI | 1 |
| Schatzberg, AF | 1 |
| Sabino, V | 1 |
| Narayan, AR | 1 |
| Zeric, T | 1 |
| Steardo, L | 1 |
| Cottone, P | 1 |
| Blednov, YA | 1 |
| Benavidez, JM | 1 |
| Black, M | 1 |
| Mayfield, J | 1 |
| Harris, RA | 1 |
| Holleran, KM | 1 |
| Wilson, HH | 1 |
| Fetterly, TL | 1 |
| Bluett, RJ | 1 |
| Centanni, SW | 1 |
| Gilfarb, RA | 1 |
| Rocco, LE | 1 |
| Patel, S | 1 |
| Winder, DG | 1 |
| Dickerson, D | 1 |
| Pittman, B | 1 |
| Ralevski, E | 1 |
| Perrino, A | 1 |
| Limoncelli, D | 2 |
| Edgecombe, J | 1 |
| Acampora, G | 1 |
| Petrakis, I | 1 |
| Shbair, MK | 1 |
| Eljabour, S | 1 |
| Lhermitte, M | 1 |
| Leach, JP | 1 |
| Mohanraj, R | 1 |
| Borland, W | 1 |
| Rusch, M | 1 |
| Lampinen, TM | 1 |
| Schilder, A | 1 |
| Hogg, RS | 1 |
| Gueorguieva, R | 2 |
| Jatlow, P | 1 |
| Boutros, NN | 1 |
| Trevisan, L | 1 |
| Gelernter, J | 1 |
| Gable, RS | 1 |
| Madonick, S | 1 |
| Perry, E | 1 |
| Brush, L | 1 |
| Wray, Y | 1 |
| Belger, A | 1 |
| D'Souza, DC | 1 |
| Yen, CF | 1 |
| Hsu, SY | 1 |
| Cheng, CP | 1 |
| Rees, H | 1 |
| Sun, H | 1 |
| Zhao, H | 1 |
| Sharpe, GM | 1 |
| Arrick, DM | 1 |
| Mayhan, WG | 1 |
| Schütz, CG | 1 |
| Soyka, M | 1 |
| Vekovischeva, OY | 1 |
| Haapalinna, A | 1 |
| Näkki, R | 1 |
| Sarviharju, M | 1 |
| Honkanen, A | 1 |
| Heikkilä, J | 1 |
| Korpi, ER | 1 |
| Grinenko, AIa | 1 |
| Krupitskiĭ, EM | 1 |
| Paleĭ, AI | 1 |
| Petrov, VN | 1 |
| Moshkov, KA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase II, Randomised, Double-blind, Placebo- Controlled, Multi-site, Parallel Group Clinical Trial to Examine Ketamine as a Pharmacological Treatment for Alcohol Dependence in an Alcohol Dependent Population[NCT02649231] | Phase 2 | 96 participants (Actual) | Interventional | 2016-10-31 | Completed | ||
| Study of the Efficacity of the Systemic Ketamine for the Improvement of Post-Operative Analgesia After ORL Carcinological Surgery at the Alcohol-Dependent Patient.[NCT00329394] | Phase 3 | 56 participants (Anticipated) | Interventional | 2006-04-30 | Suspended | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Time line follow back (NCT02649231)
Timeframe: 6 months
| Intervention | percentage of days abstinent (Mean) |
|---|---|
| Ketamine+Psychological Therapy | 86.4 |
| Ketamine+Education | 82.5 |
| Placebo+Psychological Therapy | 78.3 |
| Placebo+Education | 70.7 |
Time line follow back (NCT02649231)
Timeframe: 6 months
| Intervention | Participants (Count of Participants) |
|---|---|
| Ketamine+Psychological Therapy | 13 |
| Ketamine+Education | 15 |
| Placebo+Psychological Therapy | 14 |
| Placebo+Education | 18 |
5 reviews available for ketamine and Alcohol Drinking
| Article | Year |
|---|---|
Efficacy of ketamine intervention to decrease alcohol use, cravings, and withdrawal symptoms in adults with problematic alcohol use or alcohol use disorder: A systematic review and comprehensive analysis of mechanism of actions.
Topics: Adult; Alcohol Drinking; Alcoholism; Craving; Humans; Ketamine; Substance Withdrawal Syndrome | 2022 |
Violence against women and drug-facilitated sexual assault (DFSA): A review of the main drugs.
Topics: Adjuvants, Anesthesia; Alcohol Drinking; Anesthetics, Dissociative; Benzodiazepines; Crime Victims; | 2020 |
Drugs involved in drug-facilitated crimes: part I: alcohol, sedative-hypnotic drugs, gamma-hydroxybutyrate and ketamine. A review.
Topics: Alcohol Drinking; Anesthetics, Dissociative; Crime; Humans; Hypnotics and Sedatives; Ketamine; Sodiu | 2010 |
Alcohol and drugs in epilepsy: pathophysiology, presentation, possibilities, and prevention.
Topics: Alcohol Drinking; Alcohol Withdrawal Seizures; Alcoholism; Amphetamine-Related Disorders; Benzodiaze | 2012 |
Acute toxic effects of club drugs.
Topics: Alcohol Drinking; Animals; Behavior; Drug Interactions; Flunitrazepam; Hallucinogens; Humans; Illici | 2004 |
9 trials available for ketamine and Alcohol Drinking
| Article | Year |
|---|---|
Adjunctive Ketamine With Relapse Prevention-Based Psychological Therapy in the Treatment of Alcohol Use Disorder.
Topics: Adult; Alcohol Drinking; Alcoholism; Double-Blind Method; Female; Humans; Ketamine; Male; Recurrence | 2022 |
Ketamine can reduce harmful drinking by pharmacologically rewriting drinking memories.
Topics: Adaptation, Psychological; Adult; Alcohol Drinking; Biomarkers; Female; Humans; Ketamine; Male; Memo | 2019 |
Mystical-type experiences occasioned by ketamine mediate its impact on at-risk drinking: Results from a randomized, controlled trial.
Topics: Alcohol Drinking; Behavior, Addictive; Dissociative Disorders; Double-Blind Method; Female; Hallucin | 2021 |
A proof-of-concept investigation into ketamine as a pharmacological treatment for alcohol dependence: study protocol for a randomised controlled trial.
Topics: Adolescent; Adult; Alcohol Abstinence; Alcohol Drinking; Alcoholism; Combined Modality Therapy; Doub | 2017 |
Association of Combined Naltrexone and Ketamine With Depressive Symptoms in a Case series of Patients With Depression and Alcohol Use Disorder.
Topics: Adult; Alcohol Drinking; Alcoholism; Craving; Depressive Disorder, Major; Drug Therapy, Combination; | 2019 |
Ethanol-like effects of thiopental and ketamine in healthy humans.
Topics: Adult; Alcohol Drinking; Alcoholic Intoxication; Double-Blind Method; Ethanol; Excitatory Amino Acid | 2010 |
Altered NMDA glutamate receptor antagonist response in individuals with a family vulnerability to alcoholism.
Topics: Adult; Affect; Alcohol Drinking; Alcoholic Intoxication; Alcoholism; Brief Psychiatric Rating Scale; | 2004 |
Potentiation of low dose ketamine effects by naltrexone: potential implications for the pharmacotherapy of alcoholism.
Topics: Adult; Affect; Alcohol Drinking; Alcoholism; Double-Blind Method; Drug Synergism; Ethanol; Female; H | 2006 |
Dextromethorphan challenge in alcohol-dependent patients and controls.
Topics: Alcohol Drinking; Alcoholism; Behavior, Addictive; Dextromethorphan; Dextrorphan; Double-Blind Metho | 2000 |
13 other studies available for ketamine and Alcohol Drinking
| Article | Year |
|---|---|
Effect of ketamine on binge drinking patterns in crossed high alcohol-preferring (cHAP) mice.
Topics: Alcohol Drinking; Animals; Binge Drinking; Ethanol; Female; Humans; Ketamine; Male; Mice; Mice, Inbr | 2021 |
Pooled Urine Analysis at a Belgian Music Festival: Trends in Alcohol Consumption and Recreational Drug Use.
Topics: Alcohol Drinking; Belgium; Cocaine; Cross-Sectional Studies; Ethanol; Holidays; Humans; Illicit Drug | 2022 |
Both ketamine and NBQX attenuate alcohol drinking in male Wistar rats.
Topics: Alcohol Drinking; Animals; Depression; Kainic Acid; Ketamine; Male; Quinoxalines; Rats, Wistar; Rece | 2018 |
Target Population, Dose, and Timing Considerations for Understanding Naltrexone's Subjective Effect: Response to Amiaz.
Topics: Alcohol Drinking; Alcoholism; Antidepressive Agents; Humans; Ketamine; Naltrexone; Narcotic Antagoni | 2019 |
mTOR activation is required for the anti-alcohol effect of ketamine, but not memantine, in alcohol-preferring rats.
Topics: Alcohol Drinking; Animals; Brain; Conditioning, Operant; Ethanol; Excitatory Amino Acid Antagonists; | 2013 |
Role of interleukin-1 receptor signaling in the behavioral effects of ethanol and benzodiazepines.
Topics: Alcohol Drinking; Animals; Avoidance Learning; Behavior, Animal; Benzodiazepines; Ethanol; Female; F | 2015 |
Ketamine and MAG Lipase Inhibitor-Dependent Reversal of Evolving Depressive-Like Behavior During Forced Abstinence From Alcohol Drinking.
Topics: Affect; Alcohol Drinking; Animals; Behavior, Animal; Benzodioxoles; Depression; Endocannabinoids; Et | 2016 |
Unprotected anal intercourse associated with recreational drug use among young men who have sex with men depends on partner type and intercourse role.
Topics: Adult; Alcohol Drinking; British Columbia; Cannabis; Cohort Studies; HIV Infections; Homosexuality, | 2004 |
Polysubstance use and its correlates in adolescent ecstasy users in Taiwan.
Topics: Adolescent; Affect; Age Factors; Alcohol Drinking; Analgesics; Areca; Cross-Sectional Studies; Educa | 2007 |
Attentional bias to incentive stimuli in frequent ketamine users.
Topics: Adult; Alcohol Drinking; Amphetamine; Attention; Cocaine; Educational Status; Female; Humans; Ketami | 2008 |
Effect of chronic alcohol consumption on brain damage following transient focal ischemia.
Topics: Alcohol Drinking; Analgesics; Analysis of Variance; Animals; Body Weight; Brain Injuries; Cerebral A | 2008 |
Enhanced locomotor stimulation by NMDA receptor antagonists in alcohol-sensitive ANT rats.
Topics: Alcohol Drinking; Animals; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Isoquinolines; Ke | 2000 |
[Treatment of alcoholism by affective counterattribution].
Topics: Abreaction; Adult; Alcohol Drinking; Alcoholism; Humans; Ketamine; Male; Middle Aged; Narcotherapy | 1989 |