Page last updated: 2024-10-29

ketamine and Addiction, Opioid

ketamine has been researched along with Addiction, Opioid in 26 studies

Ketamine: A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.
ketamine : A member of the class of cyclohexanones in which one of the hydrogens at position 2 is substituted by a 2-chlorophenyl group, while the other is substituted by a methylamino group.

Research Excerpts

ExcerptRelevanceReference
"Managing severe acute nociceptive pain in buprenorphine-maintained individuals for opioid use disorder management is challenging owing to the high affinity and very slow dissociation of buprenorphine from μ-opioid receptors that hinders the use of full agonist opioid analgesics."7.96Efficacy of multimodal analgesic treatment of severe traumatic acute pain in mice pretreated with chronic high dose of buprenorphine inducing mechanical allodynia. ( Bounes, V; Coutens, B; Derreumaux, C; Frances, B; Guiard, BP; Labaste, F; Minville, V; Moulédous, L; Roussin, A, 2020)
"Ketamine is an N-methyl-d-aspartate receptor antagonist that has been shown to be useful in the reduction of acute postoperative pain and analgesic consumption in a variety of surgical interventions with variable routes of administration."6.75Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery. ( Abdu, WA; Beach, ML; Brown, JR; Clark, JA; Loftus, RW; Sengupta, DK; Yeager, MP, 2010)
" The acute pain group did not show an opioid reduction associated with the ketamine infusions."4.12Low-dose ketamine infusions reduce opioid use in pediatric and young adult oncology patients. ( Anghelescu, DL; Li, Y; Morgan, KJ; Patni, T; Ryan, S; Wu, D, 2022)
"Managing severe acute nociceptive pain in buprenorphine-maintained individuals for opioid use disorder management is challenging owing to the high affinity and very slow dissociation of buprenorphine from μ-opioid receptors that hinders the use of full agonist opioid analgesics."3.96Efficacy of multimodal analgesic treatment of severe traumatic acute pain in mice pretreated with chronic high dose of buprenorphine inducing mechanical allodynia. ( Bounes, V; Coutens, B; Derreumaux, C; Frances, B; Guiard, BP; Labaste, F; Minville, V; Moulédous, L; Roussin, A, 2020)
"We describe an opioid-tolerant patient with severe acute pain which was unrelieved by morphine and ketamine via intravenous patient-controlled analgesia, but almost totally relieved by methadone."3.71Successful use of oral methadone after failure of intravenous morphine and ketamine. ( Mitchell, SJ; Sartain, JB, 2002)
"Ketamine has been used as part of a multimodal analgesia regime in opioid abusers undergoing general anesthesia."2.78Opioid-sparing effect of preemptive bolus low-dose ketamine for moderate sedation in opioid abusers undergoing extracorporeal shock wave lithotripsy: a randomized clinical trial. ( Aghamohammadi, H; Elyassi, H; Gharaei, B; Jafari, A; Kamranmanesh, M; Poorzamani, M; Rostamian, B; Salimi, A, 2013)
"Ketamine is an N-methyl-d-aspartate receptor antagonist that has been shown to be useful in the reduction of acute postoperative pain and analgesic consumption in a variety of surgical interventions with variable routes of administration."2.75Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery. ( Abdu, WA; Beach, ML; Brown, JR; Clark, JA; Loftus, RW; Sengupta, DK; Yeager, MP, 2010)
"Demand for treatments for severe opioid use disorder is increasing worldwide."2.66Clinical benefits and risks of N-methyl-d-aspartate receptor antagonists to treat severe opioid use disorder: A systematic review. ( Fluyau, D; Pierre, CG; Revadigar, N, 2020)
"The number of registered drug abusers increased from 70,000 in 1990 to more than one million by the end of 2004."2.43Recent trends in drug abuse in China. ( Fang, YX; Liu, ZM; Lu, L; Shi, J; Wang, YB, 2006)
" Inadequate doses or dosing regimens should be avoided."2.39Pharmacology of intravenous sedatives and opioids in critically ill patients. ( Levine, RL, 1994)
"The growing social problem of drug abuse has increased the likelihood that anesthesiologists will find acute or chronic drug users among patients requiring anesthesia for elective or emergency surgery."1.37[Anesthesia in drug addiction]. ( Uña Orejón, R; Vázquez Moyano, M, 2011)
"S(+)-ketamine is a valuable adjunct in the anesthetic regimen, since it attenuates hyperactivity of the central nervous system during rapid opioid detoxification."1.33S(+)-ketamine attenuates increase in electroencephalograph activity and amplitude height of sensory-evoked potentials during rapid opioid detoxification. ( Freye, E; Latasch, L; Levy, JV, 2006)

Research

Studies (26)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (11.54)18.2507
2000's4 (15.38)29.6817
2010's11 (42.31)24.3611
2020's8 (30.77)2.80

Authors

AuthorsStudies
Silverstein, WK1
Juurlink, DN1
Zipursky, JS1
Anghelescu, DL1
Ryan, S1
Wu, D1
Morgan, KJ1
Patni, T1
Li, Y1
Ocker, AC1
Shah, NB1
Schwenk, ES1
Witkowski, TA1
Cohen, MJ1
Viscusi, ER1
Lin, C1
Wong, BY1
Lo, MT1
Chiu, YC1
Lin, YH1
Coutens, B1
Derreumaux, C1
Labaste, F1
Minville, V1
Guiard, BP1
Moulédous, L1
Bounes, V1
Roussin, A1
Frances, B1
Fluyau, D1
Revadigar, N1
Pierre, CG1
Witkin, JM1
Kranzler, J1
Kaniecki, K1
Popik, P1
Smith, JL1
Hashimoto, K1
Sporn, J1
Cobb, J1
Craig, W1
Richard, J1
Snow, E1
Turcotte, H1
Warters, R1
Quaye, A1
Zeballos, JL1
Lirk, P1
Rathmell, JP1
Nielsen, RV2
Fomsgaard, JS2
Nikolajsen, L2
Dahl, JB2
Mathiesen, O2
Barelli, R1
Morelli Sbarra, G1
Sbaraglia, F1
Zappia, L1
Rossi, M1
Kim, BW1
Peskin, RM1
Siegel, H1
Martusevicius, R1
Fredheim, OM1
Nøstdahl, T1
Nordstrand, B1
Høivik, T1
Rygnestad, T1
Borchgrevink, PC1
Angst, MS1
Clark, JD1
Loftus, RW1
Yeager, MP1
Clark, JA1
Brown, JR1
Abdu, WA1
Sengupta, DK1
Beach, ML1
Vázquez Moyano, M1
Uña Orejón, R1
Seigne, RD1
Gharaei, B1
Jafari, A1
Aghamohammadi, H1
Kamranmanesh, M1
Poorzamani, M1
Elyassi, H1
Rostamian, B1
Salimi, A1
Sartain, JB1
Mitchell, SJ1
Fang, YX1
Wang, YB1
Shi, J1
Liu, ZM1
Lu, L1
Freye, E1
Latasch, L1
Levy, JV1
Levine, RL1
Nicolodi, M1
Del Bianco, PL1
Sicuteri, F1
Connor, DF1
Muir, A1
Haller, G1
Waeber, JL1
Infante, NK1
Clergue, F1

Clinical Trials (8)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Efficacy of Different Dose Esketamine and Dexmedetomidine Combination for Supplemental Analgesia After Scoliosis Correction Surgery: A Randomized, Double-blind Trial[NCT06062550]Phase 4312 participants (Anticipated)Interventional2023-10-31Not yet recruiting
Impact of Different Dose Esketamine and Dexmedetomidine Combination for Supplemental Analgesia on Long-term Outcomes After Scoliosis Correction Surgery: Follow-up of a Randomized Trial[NCT06087510]Phase 4312 participants (Anticipated)Interventional2024-01-31Not yet recruiting
Analgesic Effects of Low-dose S-ketamine in Patients Undergoing Major Spine Fusion Surgery: A Double-blinded, Randomized Controlled Trial[NCT04964219]Phase 4164 participants (Anticipated)Interventional2022-02-08Recruiting
Effect of Mini-dose Esketamine-dexmedetomidine Supplemented Analgesia on Long-term Outcomes Following Scoliosis Correction Surgery: 2-year Follow-up of a Randomized Controlled Trial[NCT05718544]Phase 4199 participants (Actual)Interventional2023-01-30Active, not recruiting
Prospective Randomized Double Blind Study of Intraoperative Dexmedetomidine and Postoperative Pain Control in Patients Undergoing Multi-level Thoraco-lumbar Spine Surgery[NCT01850017]Phase 4142 participants (Actual)Interventional2012-08-31Completed
The Effect of Intraoperative Ketamine on Opioid Consumption and Pain After Spine Surgery in Opioid-dependent Patients[NCT02085577]Phase 4147 participants (Actual)Interventional2014-05-31Completed
A Prospective, Block Randomized, Double-Blind Placebo-Controlled Trial of Ketamine in Patients Undergoing Anterior Cervical Discectomy and Fusion[NCT02378740]Phase 40 participants (Actual)Interventional2015-04-30Withdrawn (stopped due to PI has left the University)
A Prospective, Randomized, Single Blinded Comparison of Intraoperative Ketamine Infusion Versus Placebo in Patients Having Spinal Fusion[NCT02424591]Phase 446 participants (Actual)Interventional2014-08-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Beck's Depression Inventory

"Beck's Depression Inventory (BDI) is a 21-item, self-report rating inventory that measures attitudes and symptoms of depression. Each sentence has a rating from 0 to 3 and the sentences go from mild to fairly severe descriptions of moods. The numbers are tabulated, the lowest possible score is 0 and the highest is 63.~A score of 1-10 indicates normal ups and downs. 11-16 indicates a mild mood disturbance; 17-20, borderline clinical depression; 21-30, moderate depression; 31-40, severe depression; over 40, extreme depression" (NCT02424591)
Timeframe: Post-op Day 3

Interventionpoints (Median)
Ketamine8
Placebo9

Pain Score

"McGill Short Form measures pain in different ways. The first part of the form lists 15 adjectives for pain, for which the answers can be none (0), Mild (1), Moderate (2) and Severe (3). Descriptors 1-11 represent the sensory dimension of pain experience and 12-15 represent the affective dimension. A score of 0 is good, and a score of 45 indicates extreme pain. The lower the score the less pain a subject feels (better), as the scores go up, so do the pain levels (worse).~PPI (Present Pain Intensity) asks patients to measure pain from 0 (no pain) to 5 (excruciating). Again, a lower score is ideal." (NCT02424591)
Timeframe: Post-op Day 3

Interventionpoints (Median)
Ketamine11
Placebo10.5

Scores on Questionnaires

Quality of Recovery 15 questions questionnaires that ask, on a scale of 0-10, with 0 always being bad and 10 always being best, how the patient is recovering. The total number is reviewed, so the highest total score possible is 150 and the lowest is 0. (NCT02424591)
Timeframe: Post-op Day 3

Interventionpoints (Median)
Ketamine95
Placebo101

Reviews

4 reviews available for ketamine and Addiction, Opioid

ArticleYear
Clinical benefits and risks of N-methyl-d-aspartate receptor antagonists to treat severe opioid use disorder: A systematic review.
    Drug and alcohol dependence, 2020, 03-01, Volume: 208

    Topics: Analgesics, Opioid; Excitatory Amino Acid Antagonists; Humans; Ketamine; Memantine; Methadone; Opiat

2020
[Treatment of acute pain during drug-assisted rehabilitation].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2010, Apr-08, Volume: 130, Issue:7

    Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents

2010
Recent trends in drug abuse in China.
    Acta pharmacologica Sinica, 2006, Volume: 27, Issue:2

    Topics: China; Drug and Narcotic Control; HIV Infections; Ketamine; N-Methyl-3,4-methylenedioxyamphetamine;

2006
Pharmacology of intravenous sedatives and opioids in critically ill patients.
    Critical care clinics, 1994, Volume: 10, Issue:4

    Topics: Analgesics, Opioid; Antipsychotic Agents; Barbiturates; Benzodiazepines; Cardiovascular System; Crit

1994

Trials

4 trials available for ketamine and Addiction, Opioid

ArticleYear
Intraoperative S-ketamine for the reduction of opioid consumption and pain one year after spine surgery: A randomized clinical trial of opioid-dependent patients.
    European journal of pain (London, England), 2019, Volume: 23, Issue:3

    Topics: Adult; Analgesics; Analgesics, Opioid; Double-Blind Method; Drug Administration Schedule; Female; Hu

2019
Intraoperative S-ketamine for the reduction of opioid consumption and pain one year after spine surgery: A randomized clinical trial of opioid-dependent patients.
    European journal of pain (London, England), 2019, Volume: 23, Issue:3

    Topics: Adult; Analgesics; Analgesics, Opioid; Double-Blind Method; Drug Administration Schedule; Female; Hu

2019
Intraoperative S-ketamine for the reduction of opioid consumption and pain one year after spine surgery: A randomized clinical trial of opioid-dependent patients.
    European journal of pain (London, England), 2019, Volume: 23, Issue:3

    Topics: Adult; Analgesics; Analgesics, Opioid; Double-Blind Method; Drug Administration Schedule; Female; Hu

2019
Intraoperative S-ketamine for the reduction of opioid consumption and pain one year after spine surgery: A randomized clinical trial of opioid-dependent patients.
    European journal of pain (London, England), 2019, Volume: 23, Issue:3

    Topics: Adult; Analgesics; Analgesics, Opioid; Double-Blind Method; Drug Administration Schedule; Female; Hu

2019
Intraoperative S-ketamine for the reduction of opioid consumption and pain one year after spine surgery: A randomized clinical trial of opioid-dependent patients.
    European journal of pain (London, England), 2019, Volume: 23, Issue:3

    Topics: Adult; Analgesics; Analgesics, Opioid; Double-Blind Method; Drug Administration Schedule; Female; Hu

2019
Intraoperative S-ketamine for the reduction of opioid consumption and pain one year after spine surgery: A randomized clinical trial of opioid-dependent patients.
    European journal of pain (London, England), 2019, Volume: 23, Issue:3

    Topics: Adult; Analgesics; Analgesics, Opioid; Double-Blind Method; Drug Administration Schedule; Female; Hu

2019
Intraoperative S-ketamine for the reduction of opioid consumption and pain one year after spine surgery: A randomized clinical trial of opioid-dependent patients.
    European journal of pain (London, England), 2019, Volume: 23, Issue:3

    Topics: Adult; Analgesics; Analgesics, Opioid; Double-Blind Method; Drug Administration Schedule; Female; Hu

2019
Intraoperative S-ketamine for the reduction of opioid consumption and pain one year after spine surgery: A randomized clinical trial of opioid-dependent patients.
    European journal of pain (London, England), 2019, Volume: 23, Issue:3

    Topics: Adult; Analgesics; Analgesics, Opioid; Double-Blind Method; Drug Administration Schedule; Female; Hu

2019
Intraoperative S-ketamine for the reduction of opioid consumption and pain one year after spine surgery: A randomized clinical trial of opioid-dependent patients.
    European journal of pain (London, England), 2019, Volume: 23, Issue:3

    Topics: Adult; Analgesics; Analgesics, Opioid; Double-Blind Method; Drug Administration Schedule; Female; Hu

2019
Intraoperative S-ketamine for the reduction of opioid consumption and pain one year after spine surgery: A randomized clinical trial of opioid-dependent patients.
    European journal of pain (London, England), 2019, Volume: 23, Issue:3

    Topics: Adult; Analgesics; Analgesics, Opioid; Double-Blind Method; Drug Administration Schedule; Female; Hu

2019
Intraoperative S-ketamine for the reduction of opioid consumption and pain one year after spine surgery: A randomized clinical trial of opioid-dependent patients.
    European journal of pain (London, England), 2019, Volume: 23, Issue:3

    Topics: Adult; Analgesics; Analgesics, Opioid; Double-Blind Method; Drug Administration Schedule; Female; Hu

2019
Intraoperative S-ketamine for the reduction of opioid consumption and pain one year after spine surgery: A randomized clinical trial of opioid-dependent patients.
    European journal of pain (London, England), 2019, Volume: 23, Issue:3

    Topics: Adult; Analgesics; Analgesics, Opioid; Double-Blind Method; Drug Administration Schedule; Female; Hu

2019
Intraoperative S-ketamine for the reduction of opioid consumption and pain one year after spine surgery: A randomized clinical trial of opioid-dependent patients.
    European journal of pain (London, England), 2019, Volume: 23, Issue:3

    Topics: Adult; Analgesics; Analgesics, Opioid; Double-Blind Method; Drug Administration Schedule; Female; Hu

2019
Intraoperative S-ketamine for the reduction of opioid consumption and pain one year after spine surgery: A randomized clinical trial of opioid-dependent patients.
    European journal of pain (London, England), 2019, Volume: 23, Issue:3

    Topics: Adult; Analgesics; Analgesics, Opioid; Double-Blind Method; Drug Administration Schedule; Female; Hu

2019
Intraoperative S-ketamine for the reduction of opioid consumption and pain one year after spine surgery: A randomized clinical trial of opioid-dependent patients.
    European journal of pain (London, England), 2019, Volume: 23, Issue:3

    Topics: Adult; Analgesics; Analgesics, Opioid; Double-Blind Method; Drug Administration Schedule; Female; Hu

2019
Intraoperative S-ketamine for the reduction of opioid consumption and pain one year after spine surgery: A randomized clinical trial of opioid-dependent patients.
    European journal of pain (London, England), 2019, Volume: 23, Issue:3

    Topics: Adult; Analgesics; Analgesics, Opioid; Double-Blind Method; Drug Administration Schedule; Female; Hu

2019
Intraoperative ketamine reduces immediate postoperative opioid consumption after spinal fusion surgery in chronic pain patients with opioid dependency: a randomized, blinded trial.
    Pain, 2017, Volume: 158, Issue:3

    Topics: Adult; Aged; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Chronic Pain; Double-Bli

2017
Intraoperative ketamine reduces immediate postoperative opioid consumption after spinal fusion surgery in chronic pain patients with opioid dependency: a randomized, blinded trial.
    Pain, 2017, Volume: 158, Issue:3

    Topics: Adult; Aged; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Chronic Pain; Double-Bli

2017
Intraoperative ketamine reduces immediate postoperative opioid consumption after spinal fusion surgery in chronic pain patients with opioid dependency: a randomized, blinded trial.
    Pain, 2017, Volume: 158, Issue:3

    Topics: Adult; Aged; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Chronic Pain; Double-Bli

2017
Intraoperative ketamine reduces immediate postoperative opioid consumption after spinal fusion surgery in chronic pain patients with opioid dependency: a randomized, blinded trial.
    Pain, 2017, Volume: 158, Issue:3

    Topics: Adult; Aged; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Chronic Pain; Double-Bli

2017
Intraoperative ketamine reduces immediate postoperative opioid consumption after spinal fusion surgery in chronic pain patients with opioid dependency: a randomized, blinded trial.
    Pain, 2017, Volume: 158, Issue:3

    Topics: Adult; Aged; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Chronic Pain; Double-Bli

2017
Intraoperative ketamine reduces immediate postoperative opioid consumption after spinal fusion surgery in chronic pain patients with opioid dependency: a randomized, blinded trial.
    Pain, 2017, Volume: 158, Issue:3

    Topics: Adult; Aged; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Chronic Pain; Double-Bli

2017
Intraoperative ketamine reduces immediate postoperative opioid consumption after spinal fusion surgery in chronic pain patients with opioid dependency: a randomized, blinded trial.
    Pain, 2017, Volume: 158, Issue:3

    Topics: Adult; Aged; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Chronic Pain; Double-Bli

2017
Intraoperative ketamine reduces immediate postoperative opioid consumption after spinal fusion surgery in chronic pain patients with opioid dependency: a randomized, blinded trial.
    Pain, 2017, Volume: 158, Issue:3

    Topics: Adult; Aged; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Chronic Pain; Double-Bli

2017
Intraoperative ketamine reduces immediate postoperative opioid consumption after spinal fusion surgery in chronic pain patients with opioid dependency: a randomized, blinded trial.
    Pain, 2017, Volume: 158, Issue:3

    Topics: Adult; Aged; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Chronic Pain; Double-Bli

2017
Intraoperative ketamine reduces immediate postoperative opioid consumption after spinal fusion surgery in chronic pain patients with opioid dependency: a randomized, blinded trial.
    Pain, 2017, Volume: 158, Issue:3

    Topics: Adult; Aged; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Chronic Pain; Double-Bli

2017
Intraoperative ketamine reduces immediate postoperative opioid consumption after spinal fusion surgery in chronic pain patients with opioid dependency: a randomized, blinded trial.
    Pain, 2017, Volume: 158, Issue:3

    Topics: Adult; Aged; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Chronic Pain; Double-Bli

2017
Intraoperative ketamine reduces immediate postoperative opioid consumption after spinal fusion surgery in chronic pain patients with opioid dependency: a randomized, blinded trial.
    Pain, 2017, Volume: 158, Issue:3

    Topics: Adult; Aged; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Chronic Pain; Double-Bli

2017
Intraoperative ketamine reduces immediate postoperative opioid consumption after spinal fusion surgery in chronic pain patients with opioid dependency: a randomized, blinded trial.
    Pain, 2017, Volume: 158, Issue:3

    Topics: Adult; Aged; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Chronic Pain; Double-Bli

2017
Intraoperative ketamine reduces immediate postoperative opioid consumption after spinal fusion surgery in chronic pain patients with opioid dependency: a randomized, blinded trial.
    Pain, 2017, Volume: 158, Issue:3

    Topics: Adult; Aged; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Chronic Pain; Double-Bli

2017
Intraoperative ketamine reduces immediate postoperative opioid consumption after spinal fusion surgery in chronic pain patients with opioid dependency: a randomized, blinded trial.
    Pain, 2017, Volume: 158, Issue:3

    Topics: Adult; Aged; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Chronic Pain; Double-Bli

2017
Intraoperative ketamine reduces immediate postoperative opioid consumption after spinal fusion surgery in chronic pain patients with opioid dependency: a randomized, blinded trial.
    Pain, 2017, Volume: 158, Issue:3

    Topics: Adult; Aged; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Chronic Pain; Double-Bli

2017
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
    Anesthesiology, 2010, Volume: 113, Issue:3

    Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical

2010
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
    Anesthesiology, 2010, Volume: 113, Issue:3

    Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical

2010
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
    Anesthesiology, 2010, Volume: 113, Issue:3

    Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical

2010
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
    Anesthesiology, 2010, Volume: 113, Issue:3

    Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical

2010
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
    Anesthesiology, 2010, Volume: 113, Issue:3

    Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical

2010
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
    Anesthesiology, 2010, Volume: 113, Issue:3

    Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical

2010
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
    Anesthesiology, 2010, Volume: 113, Issue:3

    Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical

2010
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
    Anesthesiology, 2010, Volume: 113, Issue:3

    Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical

2010
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
    Anesthesiology, 2010, Volume: 113, Issue:3

    Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical

2010
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
    Anesthesiology, 2010, Volume: 113, Issue:3

    Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical

2010
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
    Anesthesiology, 2010, Volume: 113, Issue:3

    Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical

2010
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
    Anesthesiology, 2010, Volume: 113, Issue:3

    Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical

2010
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
    Anesthesiology, 2010, Volume: 113, Issue:3

    Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical

2010
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
    Anesthesiology, 2010, Volume: 113, Issue:3

    Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical

2010
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
    Anesthesiology, 2010, Volume: 113, Issue:3

    Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical

2010
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
    Anesthesiology, 2010, Volume: 113, Issue:3

    Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical

2010
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
    Anesthesiology, 2010, Volume: 113, Issue:3

    Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical

2010
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
    Anesthesiology, 2010, Volume: 113, Issue:3

    Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical

2010
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
    Anesthesiology, 2010, Volume: 113, Issue:3

    Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical

2010
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
    Anesthesiology, 2010, Volume: 113, Issue:3

    Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical

2010
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
    Anesthesiology, 2010, Volume: 113, Issue:3

    Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical

2010
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
    Anesthesiology, 2010, Volume: 113, Issue:3

    Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical

2010
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
    Anesthesiology, 2010, Volume: 113, Issue:3

    Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical

2010
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
    Anesthesiology, 2010, Volume: 113, Issue:3

    Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical

2010
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
    Anesthesiology, 2010, Volume: 113, Issue:3

    Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical

2010
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
    Anesthesiology, 2010, Volume: 113, Issue:3

    Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical

2010
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
    Anesthesiology, 2010, Volume: 113, Issue:3

    Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical

2010
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
    Anesthesiology, 2010, Volume: 113, Issue:3

    Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical

2010
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
    Anesthesiology, 2010, Volume: 113, Issue:3

    Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical

2010
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
    Anesthesiology, 2010, Volume: 113, Issue:3

    Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical

2010
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
    Anesthesiology, 2010, Volume: 113, Issue:3

    Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical

2010
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
    Anesthesiology, 2010, Volume: 113, Issue:3

    Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical

2010
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
    Anesthesiology, 2010, Volume: 113, Issue:3

    Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical

2010
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
    Anesthesiology, 2010, Volume: 113, Issue:3

    Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical

2010
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
    Anesthesiology, 2010, Volume: 113, Issue:3

    Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical

2010
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
    Anesthesiology, 2010, Volume: 113, Issue:3

    Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical

2010
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
    Anesthesiology, 2010, Volume: 113, Issue:3

    Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical

2010
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
    Anesthesiology, 2010, Volume: 113, Issue:3

    Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical

2010
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
    Anesthesiology, 2010, Volume: 113, Issue:3

    Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical

2010
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
    Anesthesiology, 2010, Volume: 113, Issue:3

    Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical

2010
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
    Anesthesiology, 2010, Volume: 113, Issue:3

    Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical

2010
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
    Anesthesiology, 2010, Volume: 113, Issue:3

    Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical

2010
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
    Anesthesiology, 2010, Volume: 113, Issue:3

    Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical

2010
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
    Anesthesiology, 2010, Volume: 113, Issue:3

    Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical

2010
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
    Anesthesiology, 2010, Volume: 113, Issue:3

    Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical

2010
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
    Anesthesiology, 2010, Volume: 113, Issue:3

    Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical

2010
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
    Anesthesiology, 2010, Volume: 113, Issue:3

    Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical

2010
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
    Anesthesiology, 2010, Volume: 113, Issue:3

    Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical

2010
Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery.
    Anesthesiology, 2010, Volume: 113, Issue:3

    Topics: Adult; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Double-Blind Method; Elective Surgical

2010
Opioid-sparing effect of preemptive bolus low-dose ketamine for moderate sedation in opioid abusers undergoing extracorporeal shock wave lithotripsy: a randomized clinical trial.
    Anesthesia and analgesia, 2013, Volume: 116, Issue:1

    Topics: Adolescent; Adult; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, Dissociative; Con

2013

Other Studies

18 other studies available for ketamine and Addiction, Opioid

ArticleYear
Ketamine for the treatment of acute pain.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2021, 11-01, Volume: 193, Issue:43

    Topics: Acute Pain; Analgesics; Analgesics, Opioid; Contraindications, Drug; Dose-Response Relationship, Dru

2021
Low-dose ketamine infusions reduce opioid use in pediatric and young adult oncology patients.
    Pediatric blood & cancer, 2022, Volume: 69, Issue:9

    Topics: Acute Pain; Analgesics; Analgesics, Opioid; Child; Death; Humans; Infusions, Intravenous; Ketamine;

2022
Ketamine and Cognitive Behavioral Therapy for Rapid Opioid Tapering With Sustained Opioid Abstinence: A Case Report and 1-Year Follow-up.
    Pain practice : the official journal of World Institute of Pain, 2020, Volume: 20, Issue:1

    Topics: Analgesics; Analgesics, Opioid; Cognitive Behavioral Therapy; Follow-Up Studies; Humans; Hydromorpho

2020
Development of an addiction index and delineation 15-year trends of illicit drugs from the Taiwan national drug enhancement database.
    Journal of psychiatric research, 2020, Volume: 120

    Topics: Amphetamine-Related Disorders; Anesthetics, Dissociative; Cannabis; Central Nervous System Stimulant

2020
Efficacy of multimodal analgesic treatment of severe traumatic acute pain in mice pretreated with chronic high dose of buprenorphine inducing mechanical allodynia.
    European journal of pharmacology, 2020, May-15, Volume: 875

    Topics: Acute Pain; Analgesics; Animals; Buprenorphine; Dose-Response Relationship, Drug; Drug Therapy, Comb

2020
R-(-)-ketamine modifies behavioral effects of morphine predicting efficacy as a novel therapy for opioid use disorder
    Pharmacology, biochemistry, and behavior, 2020, Volume: 194

    Topics: Analgesics, Opioid; Animals; Antidepressive Agents; Dose-Response Relationship, Drug; Humans; Ketami

2020
Low-dose ketamine infusion for post-cesarean delivery analgesia in patients with opioid use disorder.
    International journal of obstetric anesthesia, 2021, Volume: 47

    Topics: Analgesia; Analgesics, Opioid; Cesarean Section; Double-Blind Method; Female; Humans; Ketamine; Opio

2021
Low-Dose Ketamine for Acute Pain Management: A Timely Nudge Toward Multimodal Analgesia.
    Regional anesthesia and pain medicine, 2018, Volume: 43, Issue:5

    Topics: Acute Pain; Analgesia; Analgesics; Dose-Response Relationship, Drug; Humans; Ketamine; Opioid-Relate

2018
Prevention of post-operative hyperalgesia in a heroin-addicted patient on methadone maintenance.
    Journal of clinical pharmacy and therapeutics, 2019, Volume: 44, Issue:3

    Topics: Analgesics, Opioid; Heroin; Humans; Hyperalgesia; Ketamine; Male; Methadone; Middle Aged; Opioid-Rel

2019
Dexmedetomidine, ketamine, and midazolam for oral rehabilitation: a case report.
    Anesthesia progress, 2015,Spring, Volume: 62, Issue:1

    Topics: Adult; Analgesics, Opioid; Anesthesia, Dental; Anesthetics, Combined; Anesthetics, Dissociative; Ane

2015
Ketamine for managing perioperative pain in opioid-dependent patients with chronic pain: a unique indication?
    Anesthesiology, 2010, Volume: 113, Issue:3

    Topics: Chronic Disease; Disease Management; Humans; Ketamine; Opioid-Related Disorders; Pain; Pain, Postope

2010
[Anesthesia in drug addiction].
    Revista espanola de anestesiologia y reanimacion, 2011, Volume: 58, Issue:2

    Topics: Anesthesia; Cannabinoids; Cocaine-Related Disorders; Hallucinogens; Humans; Ketamine; Opioid-Related

2011
Intraoperative ketamine and chronic opioid use: less pain, more morphine?
    Anesthesiology, 2011, Volume: 114, Issue:5

    Topics: Analgesics; Analgesics, Opioid; Chronic Disease; Follow-Up Studies; Humans; Intraoperative Care; Ket

2011
Successful use of oral methadone after failure of intravenous morphine and ketamine.
    Anaesthesia and intensive care, 2002, Volume: 30, Issue:4

    Topics: Acute Disease; Administration, Oral; Adult; Analgesia, Patient-Controlled; Analgesics; Analgesics, O

2002
S(+)-ketamine attenuates increase in electroencephalograph activity and amplitude height of sensory-evoked potentials during rapid opioid detoxification.
    Anesthesia and analgesia, 2006, Volume: 102, Issue:5

    Topics: Adult; Electroencephalography; Evoked Potentials, Somatosensory; Female; Humans; Ketamine; Male; Mid

2006
Modulation of excitatory amino acids pathway: a possible therapeutic approach to chronic daily headache associated with analgesic drugs abuse.
    International journal of clinical pharmacology research, 1997, Volume: 17, Issue:2-3

    Topics: Acetates; Adult; Amines; Chronic Disease; Cyclohexanecarboxylic Acids; Excitatory Amino Acid Antagon

1997
Balanced analgesia for the management of pain associated with multiple fractured ribs in an opioid addict.
    Anaesthesia and intensive care, 1998, Volume: 26, Issue:4

    Topics: Adult; Amides; Analgesia, Epidural; Analgesics, Opioid; Anesthetics, Dissociative; Anesthetics, Loca

1998
Ketamine combined with morphine for the management of pain in an opioid addict.
    Anesthesiology, 2002, Volume: 96, Issue:5

    Topics: Adult; Anesthetics, Intravenous; Female; Humans; Ketamine; Opioid-Related Disorders; Pain Measuremen

2002