Roles > hypoxia-inducible factor pathway activator
Page last updated: 2024-08-05 15:50:06

hypoxia-inducible factor pathway activator

An activator that activates the hypoxia inducible factor (HIF) pathway.

ChEBI ID: 134083

Members (1)

MemberDefinitionClass
ml228 probeA member of the class of 1,2,4-triazines in which the triazine ring is substituted at positions 3, 5, and 6 by pyridin-2-yl, ([biphenyl]-4-ylmethyl)amin, and methyl groups, respectively. It is an activator of the hypoxia inducible factor (HIF) pathway.ML228

Research

Studies (9)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's5 (55.56)24.3611
2020's4 (44.44)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other9 (100.00%)84.16%

Protein Targets (11)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
cytochrome P450 2C9, partialHomo sapiens (human)Potency23.918511
cytochrome P450 2D6Homo sapiens (human)Potency2.683711
cytochrome P450 family 3 subfamily A polypeptide 4Homo sapiens (human)Potency21.317411
GVesicular stomatitis virusPotency23.918511
HLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)Potency23.918511
Inositol hexakisphosphate kinase 1Homo sapiens (human)Potency23.918512
Interferon betaHomo sapiens (human)Potency7.541224
PPM1D proteinHomo sapiens (human)Potency2.082112

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Hypoxia-inducible factor 1-alphaHomo sapiens (human)EC504.952055

Other Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
aryl hydrocarbon receptor nuclear translocatorHomo sapiens (human)AC501.600011
transforming acidic coiled-coil-containing protein 3Homo sapiens (human)AC501.600011