ketamine has been researched along with Brain Edema in 13 studies
Ketamine: A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.
ketamine : A member of the class of cyclohexanones in which one of the hydrogens at position 2 is substituted by a 2-chlorophenyl group, while the other is substituted by a methylamino group.
Brain Edema: Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate the effects of ketamine pretreatment on cerebral edema following brain ischemia reperfusion injury in rats and assess the involvement of Aquaporin 4 (AQP4) expression." | 7.76 | [The effects of ketamine pretreated on cerebral edema and AQP4 expression after transient focal cerebral ischemia/reperfusion in rats]. ( Cai, SN; Zhu, SM, 2010) |
| " Transient MCAO was induced during either isoflurane or ketamine/xylazine (ket/xyl) anesthesia with simultaneously measurement of cerebral blood flow (CBF) in 60 male Wistar rats (380-420 g)." | 5.17 | Effect of anesthesia and cerebral blood flow on neuronal injury in a rat middle cerebral artery occlusion (MCAO) model. ( Bleilevens, C; Dang, J; Goetzenich, A; Hein, M; Kipp, M; Roehl, AB; Rossaint, R; Tolba, R; Zoremba, N, 2013) |
| "To investigate the effects of ketamine pretreatment on cerebral edema following brain ischemia reperfusion injury in rats and assess the involvement of Aquaporin 4 (AQP4) expression." | 3.76 | [The effects of ketamine pretreated on cerebral edema and AQP4 expression after transient focal cerebral ischemia/reperfusion in rats]. ( Cai, SN; Zhu, SM, 2010) |
| "TBI caused cerebral edema and increased concentrations of cerebral IL-1α, IL-1β, IL-6, IL-10, and tumor necrosis factor-α." | 1.37 | Effects of ketamine on endotoxin and traumatic brain injury induced cytokine production in the rat. ( Cox, CS; Harting, MT; Mercer, DW; Ward, JL, 2011) |
| "In the other 15 cats, cytotoxic brain edema (CBE) was created by an acute reduction in blood osmolality." | 1.30 | The effects of intravenous anesthetics on intracranial pressure and cerebral perfusion pressure in two feline models of brain edema. ( Nimkoff, L; Quinn, C; Sagy, M; Silver, P, 1997) |
| "Cerebral edema was assessed 0." | 1.28 | Influence of thermal stress and various agents on the brain edema formation in rats following a cryogenic brain lesion. ( Chiu, WT; Lin, LS; Lin, MT; Shih, CJ, 1989) |
| "Focal cerebral ischemia initiates multiple detrimental effects in the brain." | 1.27 | Indomethacin-mediated improvement following middle cerebral artery occlusion in cats. Effects of anesthesia. ( Dempsey, RJ; Donaldson, DL; Meyer, KL; Roy, MW, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (30.77) | 18.7374 |
| 1990's | 5 (38.46) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (30.77) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Villelli, N | 1 |
| Hauser, N | 1 |
| Gianaris, T | 1 |
| Froberg, BA | 1 |
| Fulkerson, DH | 1 |
| Cai, SN | 1 |
| Zhu, SM | 1 |
| Ward, JL | 1 |
| Harting, MT | 1 |
| Cox, CS | 1 |
| Mercer, DW | 1 |
| Bleilevens, C | 1 |
| Roehl, AB | 1 |
| Goetzenich, A | 1 |
| Zoremba, N | 1 |
| Kipp, M | 1 |
| Dang, J | 1 |
| Tolba, R | 1 |
| Rossaint, R | 1 |
| Hein, M | 1 |
| Shapira, Y | 1 |
| Lam, AM | 1 |
| Eng, CC | 1 |
| Laohaprasit, V | 1 |
| Michel, M | 1 |
| Nimkoff, L | 1 |
| Quinn, C | 1 |
| Silver, P | 1 |
| Sagy, M | 1 |
| Mills, CD | 1 |
| Robertson, CS | 1 |
| Contant, CF | 1 |
| Henley, CM | 1 |
| Siegal, T | 2 |
| Shohami, E | 1 |
| Lossos, F | 1 |
| Gaab, MR | 1 |
| Poch, B | 1 |
| Heller, V | 1 |
| Lin, LS | 1 |
| Chiu, WT | 1 |
| Shih, CJ | 1 |
| Lin, MT | 1 |
| Dempsey, RJ | 1 |
| Roy, MW | 1 |
| Meyer, KL | 1 |
| Donaldson, DL | 1 |
| Pichlmayr, I | 1 |
| Brophy, T | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Ketamine Versus Sufentanil on Cerebral Glutamate After Traumatic Brain Injury : a Randomized, Double-blinded, Microdialysis Study[NCT02232347] | Phase 2 | 20 participants (Anticipated) | Interventional | 2014-10-31 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for ketamine and Brain Edema
| Article | Year |
|---|---|
[Basis and new aspects of the effect of anaesthetics on cerebral function].
Topics: Anesthetics; Barbiturates; Brain; Brain Edema; Brain Neoplasms; Cerebrovascular Circulation; Chlorof | 1973 |
1 trial available for ketamine and Brain Edema
| Article | Year |
|---|---|
Effect of anesthesia and cerebral blood flow on neuronal injury in a rat middle cerebral artery occlusion (MCAO) model.
Topics: Anesthesia; Anesthetics; Animals; Blood Pressure; Brain Edema; Brain Injuries; Cerebral Infarction; | 2013 |
11 other studies available for ketamine and Brain Edema
| Article | Year |
|---|---|
Severe bilateral cerebellar edema from ingestion of ketamine: case report.
Topics: Analgesics; Brain Edema; Cerebellum; Female; Humans; Infant; Ketamine; Magnetic Resonance Imaging | 2017 |
[The effects of ketamine pretreated on cerebral edema and AQP4 expression after transient focal cerebral ischemia/reperfusion in rats].
Topics: Animals; Aquaporin 4; Brain; Brain Edema; Brain Ischemia; Ischemic Preconditioning; Ketamine; Male; | 2010 |
Effects of ketamine on endotoxin and traumatic brain injury induced cytokine production in the rat.
Topics: Analysis of Variance; Animals; Brain Edema; Brain Injuries; Cytokines; Endotoxemia; Endotoxins; Keta | 2011 |
Therapeutic time window and dose response of the beneficial effects of ketamine in experimental head injury.
Topics: Analysis of Variance; Animals; Brain; Brain Edema; Brain Injuries; Cerebral Hemorrhage; Dose-Respons | 1994 |
The effects of intravenous anesthetics on intracranial pressure and cerebral perfusion pressure in two feline models of brain edema.
Topics: Analysis of Variance; Anesthetics, Intravenous; Animals; Blood Pressure; Brain Edema; Cats; Cerebrov | 1997 |
Effects of anesthesia on polyamine metabolism and water content in the rat brain.
Topics: Anesthesia, General; Anesthetics, General; Animals; Biogenic Polyamines; Body Water; Brain Chemistry | 1997 |
Experimental neoplastic spinal cord compression: effect of ketamine and MK-801 on edema and prostaglandins.
Topics: Analysis of Variance; Animals; Brain Edema; Dibenzocycloheptenes; Dizocilpine Maleate; Edema; Histio | 1990 |
Oxygen tension, oxygen metabolism, and microcirculation in vasogenic brain edema.
Topics: Animals; Brain Edema; Brain Injuries; Cerebrovascular Circulation; Cold Temperature; Ketamine; Male; | 1990 |
Influence of thermal stress and various agents on the brain edema formation in rats following a cryogenic brain lesion.
Topics: Animals; Body Water; Brain Edema; Brain Injuries; Cold Temperature; Glycerol; Hot Temperature; Ketam | 1989 |
Indomethacin-mediated improvement following middle cerebral artery occlusion in cats. Effects of anesthesia.
Topics: Animals; Brain Edema; Brain Ischemia; Cats; Cerebral Arteries; Cerebrovascular Circulation; Evoked P | 1985 |
Paediatric neurosurgical and neuroradiological anaesthesia.
Topics: Anesthesia, General; Anesthesia, Inhalation; Anesthetics; Blood-Brain Barrier; Brain Edema; Carbon D | 1973 |