Page last updated: 2024-10-29

ketamine and Behavior Disorders

ketamine has been researched along with Behavior Disorders in 63 studies

Ketamine: A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.
ketamine : A member of the class of cyclohexanones in which one of the hydrogens at position 2 is substituted by a 2-chlorophenyl group, while the other is substituted by a methylamino group.

Research Excerpts

ExcerptRelevanceReference
" This article examines the advantages and applications of INDD in neuropsychiatry; provides examples of test, experimental, and approved INDD treatments; and focuses especially on the potential of intranasal ketamine for the acute and maintenance therapy of refractory depression."8.91Intranasal drug delivery in neuropsychiatry: focus on intranasal ketamine for refractory depression. ( Andrade, C, 2015)
" Considering the lack of understanding concerning the pathophysiology of schizophrenia, the present study hypothesized that omega 3 prevents the onset of symptoms similar to schizophrenia in young Wistar rats submitted to ketamine treatment."7.80Omega-3 prevents behavior response and brain oxidative damage in the ketamine model of schizophrenia. ( Binatti, AR; Budni, J; Chipindo, HL; da Rosa Silveira, F; de Oliveira, MB; Gama, CS; Heylmann, AS; Maravai, SG; Mastella, GA; Panizzutti, B; Quevedo, J; Schuck, PF; Steckert, AV; Volpato, AM; Wessler, PG; Zugno, AI, 2014)
"Ketamine is a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist with demonstrated antidepressant effects in the adult population, however, the efficacy and safety of ketamine for the treatment of pediatric depression remains poorly understood."6.82Ketamine use in pediatric depression: A systematic review. ( Cao, B; Ceban, F; Chisamore, N; Danayan, K; Ho, RC; McIntyre, RS; Meshkat, S; Rhee, TG; Rosenblat, JD; Vincenzo, JDD, 2022)
" This article examines the advantages and applications of INDD in neuropsychiatry; provides examples of test, experimental, and approved INDD treatments; and focuses especially on the potential of intranasal ketamine for the acute and maintenance therapy of refractory depression."4.91Intranasal drug delivery in neuropsychiatry: focus on intranasal ketamine for refractory depression. ( Andrade, C, 2015)
" Considering the lack of understanding concerning the pathophysiology of schizophrenia, the present study hypothesized that omega 3 prevents the onset of symptoms similar to schizophrenia in young Wistar rats submitted to ketamine treatment."3.80Omega-3 prevents behavior response and brain oxidative damage in the ketamine model of schizophrenia. ( Binatti, AR; Budni, J; Chipindo, HL; da Rosa Silveira, F; de Oliveira, MB; Gama, CS; Heylmann, AS; Maravai, SG; Mastella, GA; Panizzutti, B; Quevedo, J; Schuck, PF; Steckert, AV; Volpato, AM; Wessler, PG; Zugno, AI, 2014)
"Limited published data exists that collates serious adverse outcomes involving ketamine as a psychiatric intervention."3.54A systematic review of the incidence of medical serious adverse events in sub-anesthetic ketamine treatment of psychiatric disorders. ( Frizzell, W; Gerrish, W; Hovda, N; Shackelford, R, 2024)
"Ketamine has shown effect for the treatment of resistant depression."3.01 ( Ibrahim, IB; Straszek, SPV; Videbech, P, 2023)
"Ketamine is a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist with demonstrated antidepressant effects in the adult population, however, the efficacy and safety of ketamine for the treatment of pediatric depression remains poorly understood."2.82Ketamine use in pediatric depression: A systematic review. ( Cao, B; Ceban, F; Chisamore, N; Danayan, K; Ho, RC; McIntyre, RS; Meshkat, S; Rhee, TG; Rosenblat, JD; Vincenzo, JDD, 2022)
"Esketamine was recently licensed by the US Food and Drug Administration (FDA) and European Drug Agency (EDA) for use in treatment resistant depression (TRD), and further research indicates ketamine as a possible treatment in other mental health conditions."2.66Ketamine as a mental health treatment: Are acute psychoactive effects associated with outcomes? A systematic review. ( Borissova, A; Curran, HV; Grabski, M; Marsh, B; Morgan, CJA, 2020)
"Ketamine has been available for approximately 50 years as an anesthetic agent."2.53Has psychiatry tamed the "ketamine tiger?" Considerations on its use for depression and anxiety. ( Rasmussen, KG, 2016)
"Ketamine is a dissociative anesthetic and substance of abuse."2.50Ketamine: an update on its abuse. ( Anderson, PD; Bokor, G, 2014)
"Ketamine is a phencyclidine derivative acting primarily as a noncompetitive antagonist of N-methyl-D-aspartate (NMDA) excitatory glutamate receptors."2.45[Advances in research of ketamine addiction mechanism]. ( Bian, SZ; Gu, ZL; Jiang, XG; Liu, WL; Qin, ZH, 2009)
" Ten adverse mental status events were documented in nine subjects/infusions that were deemed related to ketamine administration (2% of subjects, 1."2.44Psychiatric safety of ketamine in psychopharmacology research. ( Cho, HS; Cramer, JA; D'Souza, DC; Genovese, A; Karper, LP; Krystal, JH; O'Donnell, E; Perry, EB; Petrakis, IL, 2007)
"Ketamine is a noncompetitive NMDA receptor antagonist and comes into being a new problem of drug abuse."2.44[A reviewing for abusing of ketamine]. ( Bian, SZ; Yang, J, 2007)
"Ketamine has received increasing attention in recent years for pre-hospital sedation of behaviourally disturbed patients, predominantly with psychiatric illness."1.56Impact of a ketamine sedation protocol on intubation rates and undesirable outcomes in the transport of patients with acute behavioural disturbance. ( Johnson, R; Shahtahmasebi, R; Shahtahmasebi, S, 2020)
"Oral ketamine is an effective premedication for major ambulatory surgery and does not increase the incidence of side effects."1.36[Oral ketamine-midazolam premedication of uncooperative patients in major outpatient surgery]. ( Cano, G; Caparros, P; Cortiñas, M; Ibarra, M; Martínez, L; Oya, B, 2010)
" Addictive/dependent patterns of behaviour were also a concern: the majority of frequent users reported using the drug without stopping until supplies ran out and the mean increase in dosage in this group was six-fold from initiation to current use."1.35Journey through the K-hole: phenomenological aspects of ketamine use. ( Curran, HV; Kamboj, SK; Morgan, CJ; Muetzelfeldt, L; Rees, H; Taylor, J, 2008)

Research

Studies (63)

TimeframeStudies, this research(%)All Research%
pre-19903 (4.76)18.7374
1990's2 (3.17)18.2507
2000's11 (17.46)29.6817
2010's27 (42.86)24.3611
2020's20 (31.75)2.80

Authors

AuthorsStudies
Dutton, M2
Can, AT2
Beaudequin, D1
Jensen, E1
Jones, M1
Gallay, CC1
Schwenn, PE1
Scherman, JK1
Yang, C1
Forsyth, G1
Lagopoulos, J2
Hermens, DF2
Giacobbe, P1
Burhan, AM1
Waxman, R1
Ng, E1
Miller, AH1
Raison, CL1
Young, AH1
Ibrahim, IB1
Videbech, P1
Straszek, SPV1
Meshkat, S1
Rosenblat, JD1
Ho, RC1
Rhee, TG1
Cao, B1
Ceban, F1
Danayan, K1
Chisamore, N1
Vincenzo, JDD1
McIntyre, RS1
Hovda, N1
Gerrish, W1
Frizzell, W1
Shackelford, R1
Wojtas, A1
Cottone, JG1
Nutt, D1
Belenichev, I1
Burlaka, B1
Puzyrenko, A1
Ryzhenko, O1
Kurochkin, M1
Yusuf, J1
Corne, R1
Mongeau, R1
Grabski, M1
Borissova, A1
Marsh, B1
Morgan, CJA1
Curran, HV2
Akinosoglou, K1
Gogos, A1
Papageorgiou, C1
Angelopoulos, E1
Gogos, C1
De Gregorio, D1
Aguilar-Valles, A1
Preller, KH1
Heifets, BD2
Hibicke, M1
Mitchell, J1
Gobbi, G1
Passie, T1
Adams, HA1
Logemann, F1
Brandt, SD1
Wiese, B1
Karst, M1
Davis-Reyes, BD1
Smith, AE1
Xu, J1
Cunningham, KA1
Zhou, J1
Anastasio, NC1
Włodarczyk, A1
Cubała, WJ1
Gąsior, M1
Muthukumaraswamy, SD1
Forsyth, A1
Lumley, T1
Davey, CG1
Kadriu, B1
Musazzi, L1
Johnston, JN1
Kalynchuk, LE1
Caruncho, HJ1
Popoli, M1
Zarate, CA1
Parsch, CS1
Boonstra, A1
Teubner, D1
Emmerton, W1
McKenny, B1
Ellis, DY1
Nazarian, DJ1
Broder, JS1
Thiessen, MEW1
Wilson, MP1
Zun, LS1
Brown, MD1
Phillips, AG1
Geyer, MA1
Robbins, TW1
Thalman, C1
Horta, G1
Qiao, L1
Endle, H1
Tegeder, I1
Cheng, H1
Laube, G1
Sigurdsson, T1
Hauser, MJ1
Tenzer, S1
Distler, U1
Aoki, J1
Morris, AJ1
Geisslinger, G1
Röper, J1
Kirischuk, S1
Luhmann, HJ1
Radyushkin, K1
Nitsch, R1
Vogt, J1
Kozono, N1
Honda, S1
Tada, M1
Kirihara, K1
Zhao, Z1
Jinde, S1
Uka, T1
Yamada, H1
Matsumoto, M1
Kasai, K1
Mihara, T1
Malenka, RC1
Shahtahmasebi, R1
Johnson, R1
Shahtahmasebi, S1
Carhart-Harris, RL1
Brugger, S1
Nutt, DJ1
Stone, JM1
Arnold, C1
Zugno, AI1
Chipindo, HL1
Volpato, AM1
Budni, J1
Steckert, AV1
de Oliveira, MB1
Heylmann, AS1
da Rosa Silveira, F1
Mastella, GA1
Maravai, SG1
Wessler, PG1
Binatti, AR1
Panizzutti, B1
Schuck, PF1
Quevedo, J1
Gama, CS1
Bokor, G1
Anderson, PD1
Zhao, T1
Li, Y1
Wei, W1
Savage, S1
Zhou, L1
Ma, D1
Tang, WK1
Morgan, CJ2
Lau, GC1
Liang, HJ1
Tang, A1
Ungvari, GS1
Rasmussen, KG1
Arteche Andrés, MA1
Zugasti Echarte, O1
de Carlos Errea, J1
Pérez Rodríguez, M1
Leyún Pérez de Zabalza, R1
Azcona Calahorra, MA1
Andrade, C1
Manji, H1
Mullard, A1
Amat, J1
Dolzani, SD1
Tilden, S1
Christianson, JP1
Kubala, KH1
Bartholomay, K1
Sperr, K1
Ciancio, N1
Watkins, LR1
Maier, SF1
Wu, R1
Zhang, H1
Xue, W1
Zou, Z1
Lu, C2
Xia, B1
Wang, W1
Chen, G1
da Silveira, VT1
Medeiros, DC1
Ropke, J1
Guidine, PA1
Rezende, GH1
Moraes, MF1
Mendes, EM1
Macedo, D1
Moreira, FA1
de Oliveira, AC1
Grande, LA1
Liu, WL1
Bian, SZ2
Gu, ZL1
Jiang, XG1
Qin, ZH1
Cortiñas, M1
Oya, B1
Caparros, P1
Cano, G1
Ibarra, M1
Martínez, L1
Le Cong, M1
Gynther, B1
Hunter, E1
Schuller, P1
Nagels, A1
Kirner-Veselinovic, A1
Wiese, R1
Paulus, FM1
Kircher, T1
Krach, S1
Zhang, Y1
Zhang, J1
Hu, L1
Song, H1
Li, J1
Kang, L1
Chan, WP1
Chilvers, CR1
Fredriksson, A1
Archer, T1
Cunningham, MO1
Hunt, J1
Middleton, S1
LeBeau, FE1
Gillies, MJ1
Gillies, MG1
Davies, CH1
Maycox, PR1
Whittington, MA1
Racca, C1
Howland, RH1
Bleiberg, AH1
Salvaggio, CA1
Roy, LC1
Kassutto, Z1
Perry, EB1
Cramer, JA1
Cho, HS1
Petrakis, IL1
Karper, LP1
Genovese, A1
O'Donnell, E1
Krystal, JH2
D'Souza, DC1
Yang, J1
Muetzelfeldt, L1
Kamboj, SK1
Rees, H1
Taylor, J1
Smalla, KH1
Mikhaylova, M1
Sahin, J1
Bernstein, HG1
Bogerts, B1
Schmitt, A1
van der Schors, R1
Smit, AB1
Li, KW1
Gundelfinger, ED1
Kreutz, MR1
Tamminga, CA1
Conley, RR1
Anand, A1
Charney, DS1
Oren, DA1
Berman, RM1
Hu, XS1
Cappiello, A1
Biersner, RJ1
Harris, JA1
Ryman, DH1
Lilburn, JK1
Dundee, JW1
Nair, SG1
Hausler, R1
Cao, M1
Magnin, C1
Mulette, P1
Ghoneim, MM1
Hinrichs, JV1
Mewaldt, SP1
Petersen, RC1

Clinical Trials (7)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Phase II, Randomised, Double-blind, Placebo- Controlled, Multi-site, Parallel Group Clinical Trial to Examine Ketamine as a Pharmacological Treatment for Alcohol Dependence in an Alcohol Dependent Population[NCT02649231]Phase 296 participants (Actual)Interventional2016-10-31Completed
Ketamine Versus Midazolam for Prehospital Agitation[NCT03554915]314 participants (Actual)Observational2017-08-01Completed
ED Treatment of Suicidal Patients With Ketamine Infusion[NCT03502551]Phase 20 participants (Actual)Interventional2019-04-01Withdrawn (stopped due to Trial never received funding.)
Intramuscular Ketamine Versus Escitalopram and Aripiprazole in Acute and Maintenance Treatment of Patients With Treatment-resistant Depression[NCT04234776]Phase 488 participants (Anticipated)Interventional2018-04-03Enrolling by invitation
Initiating Ketamine in Acutely Suicidal Patients in the Emergency Department[NCT04260607]Phase 32 participants (Actual)Interventional2020-01-14Terminated (stopped due to As a busy MTF we were unable to retain a health care provider with the appropriate expertise to buy-in to this study once the initiating PI left military service.)
Effects of Low-dose S-ketamine on the Incidence of Postpartum Depression in Women With Prenatal Depression: a Randomized, Double-blind, Placebo-controlled Trial[NCT04414943]364 participants (Actual)Interventional2020-06-19Completed
An Investigation of the Antidepressant Efficacy and Safety of an AMPAkine (Org 24448) in Major Depressive Disorder, A Double-Blind, Placebo-Controlled, Randomized Study[NCT00113022]Phase 29 participants (Actual)Interventional2005-05-31Terminated (stopped due to Terminated due to concerns about adverse events in separate study.)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Percentage Days Abstinent

Time line follow back (NCT02649231)
Timeframe: 6 months

Interventionpercentage of days abstinent (Mean)
Ketamine+Psychological Therapy86.4
Ketamine+Education82.5
Placebo+Psychological Therapy78.3
Placebo+Education70.7

Relapse Rates

Time line follow back (NCT02649231)
Timeframe: 6 months

InterventionParticipants (Count of Participants)
Ketamine+Psychological Therapy13
Ketamine+Education15
Placebo+Psychological Therapy14
Placebo+Education18

Montgomery-Asberg Depression Rating Scale (MADRS)

The MADRS is a measure of depression severity examined on a weekly basis. The minimum score on the 10 item scale is 0 indicating no depression. The maximum score is 60 indicating a very severe depression. Scores of 18 and above are generally considered to suggest significant levels of depression. (NCT00113022)
Timeframe: 8 weeks

InterventionScores on a scale (Least Squares Mean)
Org 2444826.425
Placebo24.205

Reviews

22 reviews available for ketamine and Behavior Disorders

ArticleYear
Stress, mental disorder and ketamine as a novel, rapid acting treatment.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2022, Volume: 65

    Topics: Antidepressive Agents; Humans; Hypothalamo-Hypophyseal System; Ketamine; Mental Disorders; Pituitary

2022
Interventional Psychiatry and Neurotechnologies: Education and Ethics Training.
    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 2023, Volume: 50, Issue:s1

    Topics: Curriculum; Humans; Ketamine; Mental Disorders; Psychiatry; Transcranial Magnetic Stimulation

2023
    Ugeskrift for laeger, 2023, Aug-07, Volume: 185, Issue:32

    Topics: Escitalopram; Hallucinogens; Humans; Ketamine; Mental Disorders; Psilocybin

2023
Ketamine use in pediatric depression: A systematic review.
    Psychiatry research, 2022, Volume: 317

    Topics: Adolescent; Adult; Child; Databases, Factual; Depression; Humans; Ketamine; Mental Disorders; Random

2022
A systematic review of the incidence of medical serious adverse events in sub-anesthetic ketamine treatment of psychiatric disorders.
    Journal of affective disorders, 2024, 01-15, Volume: 345

    Topics: Adult; Anesthetics; Disease Progression; Humans; Incidence; Ketamine; Mental Disorders

2024
The possible place for psychedelics in pharmacotherapy of mental disorders.
    Pharmacological reports : PR, 2023, Volume: 75, Issue:6

    Topics: Antidepressive Agents; Hallucinogens; Humans; Ketamine; Mental Disorders; Psilocybin; Serotonin

2023
Psychedelic drugs-a new era in
psychiatry?
.
    Dialogues in clinical neuroscience, 2019, Volume: 21, Issue:2

    Topics: Hallucinogens; Humans; Ketamine; Lysergic Acid Diethylamide; Mental Disorders; N-Methyl-3,4-methylen

2019
[Neurotrophic mechanisms of psychedelic therapy].
    Biologie aujourd'hui, 2019, Volume: 213, Issue:3-4

    Topics: Animals; Hallucinogens; Humans; Ibogaine; Ketamine; Mental Disorders; Nerve Growth Factors; Psychiat

2019
Ketamine as a mental health treatment: Are acute psychoactive effects associated with outcomes? A systematic review.
    Behavioural brain research, 2020, 08-17, Volume: 392

    Topics: Adult; Antidepressive Agents; Depressive Disorder, Major; Depressive Disorder, Treatment-Resistant;

2020
Hallucinogens in Mental Health: Preclinical and Clinical Studies on LSD, Psilocybin, MDMA, and Ketamine.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021, 02-03, Volume: 41, Issue:5

    Topics: Animals; Brain; Hallucinogens; Humans; Ketamine; Lysergic Acid Diethylamide; Mental Disorders; Menta

2021
Blinding and expectancy confounds in psychedelic randomized controlled trials.
    Expert review of clinical pharmacology, 2021, Volume: 14, Issue:9

    Topics: Confounding Factors, Epidemiologic; Hallucinogens; Humans; Ketamine; Lysergic Acid Diethylamide; Men

2021
Positive AMPA receptor modulation in the treatment of neuropsychiatric disorders: A long and winding road.
    Drug discovery today, 2021, Volume: 26, Issue:12

    Topics: Animals; Antidepressive Agents; Drug Development; Drug Discovery; Humans; Ketamine; Mental Disorders

2021
Clinical Policy: Critical Issues in the Diagnosis and Management of the Adult Psychiatric Patient in the Emergency Department.
    Annals of emergency medicine, 2017, Volume: 69, Issue:4

    Topics: Acute Disease; Adult; Emergency Service, Hospital; Emergency Treatment; Evidence-Based Medicine; Exc

2017
Effective Use of Animal Models for Therapeutic Development in Psychiatric and Substance Use Disorders.
    Biological psychiatry, 2018, 06-01, Volume: 83, Issue:11

    Topics: Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents; Atomoxetine Hydrochloride; Attention D

2018
Ketamine: an update on its abuse.
    Journal of pharmacy practice, 2014, Volume: 27, Issue:6

    Topics: Gastrointestinal Diseases; Humans; Ketamine; Mental Disorders; Substance-Related Disorders; Urologic

2014
Has psychiatry tamed the "ketamine tiger?" Considerations on its use for depression and anxiety.
    Progress in neuro-psychopharmacology & biological psychiatry, 2016, Jan-04, Volume: 64

    Topics: Analgesics; Animals; Antidepressive Agents; Humans; Ketamine; Mental Disorders

2016
Intranasal drug delivery in neuropsychiatry: focus on intranasal ketamine for refractory depression.
    The Journal of clinical psychiatry, 2015, Volume: 76, Issue:5

    Topics: Administration, Intranasal; Depressive Disorder, Treatment-Resistant; Humans; Ketamine; Mental Disor

2015
[Advances in research of ketamine addiction mechanism].
    Fa yi xue za zhi, 2009, Volume: 25, Issue:3

    Topics: Anesthetics, Dissociative; Animals; Brain; Humans; Illicit Drugs; Ketamine; Mental Disorders; Rats;

2009
Glutamate-modulating drugs & the treatment of mental disorders.
    Journal of psychosocial nursing and mental health services, 2007, Volume: 45, Issue:1

    Topics: Acamprosate; Amantadine; Cycloserine; Glutamic Acid; Humans; Ketamine; Lamotrigine; Memantine; Menta

2007
Psychiatric safety of ketamine in psychopharmacology research.
    Psychopharmacology, 2007, Volume: 192, Issue:2

    Topics: Adult; Aged; Clinical Trials as Topic; Dose-Response Relationship, Drug; Excitatory Amino Acid Antag

2007
[A reviewing for abusing of ketamine].
    Fa yi xue za zhi, 2007, Volume: 23, Issue:4

    Topics: Anesthetics, Dissociative; Cerebral Cortex; Humans; Illicit Drugs; Ketamine; Mental Disorders; Recep

2007
The application of neuroimaging techniques to drug development.
    The Journal of clinical psychiatry, 1997, Volume: 58 Suppl 10

    Topics: Antipsychotic Agents; Brain; Brain Chemistry; Carbon Radioisotopes; Cerebrovascular Circulation; Deo

1997

Trials

5 trials available for ketamine and Behavior Disorders

ArticleYear
Comparative effects of (S)-ketamine and racemic (R/S)-ketamine on psychopathology, state of consciousness and neurocognitive performance in healthy volunteers.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2021, Volume: 44

    Topics: Analgesics; Antidepressive Agents; Consciousness; Healthy Volunteers; Humans; Ketamine; Male; Mental

2021
Effects of ketamine-induced psychopathological symptoms on continuous overt rhyme fluency.
    European archives of psychiatry and clinical neuroscience, 2012, Volume: 262, Issue:5

    Topics: Adult; Brain; Brain Mapping; Cognition Disorders; Double-Blind Method; Excitatory Amino Acid Antagon

2012
Attenuation of the neuropsychiatric effects of ketamine with lamotrigine: support for hyperglutamatergic effects of N-methyl-D-aspartate receptor antagonists.
    Archives of general psychiatry, 2000, Volume: 57, Issue:3

    Topics: Adult; Affect; Brief Psychiatric Rating Scale; Cognition Disorders; Double-Blind Method; Excitatory

2000
Attenuation of psychic sequelae from ketamine [proceedings].
    British journal of clinical pharmacology, 1977, Volume: 4, Issue:5

    Topics: Humans; Ketamine; Mental Disorders; Preanesthetic Medication; Tranquilizing Agents

1977
Ketamine: behavioral effects of subanesthetic doses.
    Journal of clinical psychopharmacology, 1985, Volume: 5, Issue:2

    Topics: Adolescent; Adult; Affect; Female; Headache; Humans; Ketamine; Learning; Male; Memory; Mental Disord

1985

Other Studies

36 other studies available for ketamine and Behavior Disorders

ArticleYear
Oral ketamine reduces the experience of stress in people with chronic suicidality.
    Journal of affective disorders, 2022, 03-01, Volume: 300

    Topics: Adult; Female; Humans; Ketamine; Mental Disorders; Self Report; Suicidal Ideation; Suicide

2022
Psychedelics and ketamine are a symptom of psychiatry's woes, not a cure.
    Molecular psychiatry, 2023, Volume: 28, Issue:8

    Topics: Hallucinogens; Humans; Ketamine; Mental Disorders; Psychiatry

2023
Ketamine: A new chapter for clinical psychopharmacology?
    Journal of psychopharmacology (Oxford, England), 2023, Volume: 37, Issue:8

    Topics: Humans; Ketamine; Mental Disorders; Psychopharmacology

2023
Ketamine-Assisted Psychodynamic Psychotherapy.
    Psychodynamic psychiatry, 2023, Volume: 51, Issue:4

    Topics: Female; Humans; Ketamine; Mental Disorders; Middle Aged; Psychotherapy; Psychotherapy, Psychodynamic

2023
MANAGEMENT OF AMNESTIC AND BEHAVIORAL DISORDERS AFTER KETAMINE ANESTHESIA.
    Georgian medical news, 2019, Issue:294

    Topics: Amnesia; Anesthesia; Anesthesia, General; Animals; Dipeptides; Ketamine; Mental Disorders; Neuroprot

2019
Ketamine in COVID-19 patients: Thinking out of the box.
    Journal of medical virology, 2021, Volume: 93, Issue:7

    Topics: COVID-19; COVID-19 Drug Treatment; Humans; Ketamine; Mental Disorders

2021
Subanesthetic ketamine with an AMPAkine attenuates motor impulsivity in rats.
    Behavioural pharmacology, 2021, 06-01, Volume: 32, Issue:4

    Topics: Animals; Antidepressive Agents; Cognition; Dose-Response Relationship, Drug; Glutamic Acid; Impulsiv

2021
Commentary on: Comparative effects of (S)-ketamine and racemic (R/S)-ketamine on psychopathology, state of consciousness, and neurocognitive performance in healthy volunteers.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2021, Volume: 49

    Topics: Consciousness; Healthy Volunteers; Humans; Ketamine; Mental Disorders; Psychopathology

2021
Out of the night-time and into the day: Ketamine and MDMA as therapies for mental disorders.
    The Australian and New Zealand journal of psychiatry, 2021, Volume: 55, Issue:8

    Topics: Hallucinogens; Humans; Ketamine; Mental Disorders; Methamphetamine; N-Methyl-3,4-methylenedioxyamphe

2021
Ketamine reduces the need for intubation in patients with acute severe mental illness and agitation requiring transport to definitive care: An observational study.
    Emergency medicine Australasia : EMA, 2017, Volume: 29, Issue:3

    Topics: Adolescent; Adult; Cohort Studies; Emergency Medical Services; Female; Humans; Hypnotics and Sedativ

2017
Synaptic phospholipids as a new target for cortical hyperexcitability and E/I balance in psychiatric disorders.
    Molecular psychiatry, 2018, Volume: 23, Issue:8

    Topics: Animals; Astrocytes; Cells, Cultured; Central Nervous System Agents; Cerebral Cortex; Disease Models

2018
Auditory Steady State Response; nature and utility as a translational science tool.
    Scientific reports, 2019, 06-11, Volume: 9, Issue:1

    Topics: Acoustic Stimulation; Adult; Animals; Auditory Cortex; Brain; Disease Models, Animal; Electroencepha

2019
Disruptive Psychopharmacology.
    JAMA psychiatry, 2019, 08-01, Volume: 76, Issue:8

    Topics: Consciousness; Humans; Ketamine; Mental Disorders; N-Methyl-3,4-methylenedioxyamphetamine; Psilocybi

2019
Impact of a ketamine sedation protocol on intubation rates and undesirable outcomes in the transport of patients with acute behavioural disturbance.
    Emergency medicine Australasia : EMA, 2020, Volume: 32, Issue:1

    Topics: Adult; Anesthetics, Dissociative; Emergency Medical Services; Female; Humans; Intubation, Intratrach

2020
Psychiatry's next top model: cause for a re-think on drug models of psychosis and other psychiatric disorders.
    Journal of psychopharmacology (Oxford, England), 2013, Volume: 27, Issue:9

    Topics: Amphetamine; Cannabis; Drug Users; Ethanol; Female; Humans; Ketamine; Male; Mental Disorders; Pilot

2013
The promise and perils of ketamine research.
    The Lancet. Neurology, 2013, Volume: 12, Issue:10

    Topics: Biomedical Research; Excitatory Amino Acid Antagonists; Humans; Ketamine; Mental Disorders; Psychoph

2013
Omega-3 prevents behavior response and brain oxidative damage in the ketamine model of schizophrenia.
    Neuroscience, 2014, Feb-14, Volume: 259

    Topics: Animals; Brain; Brain Injuries; Disease Models, Animal; Dose-Response Relationship, Drug; Fatty Acid

2014
Ketamine administered to pregnant rats in the second trimester causes long-lasting behavioral disorders in offspring.
    Neurobiology of disease, 2014, Volume: 68

    Topics: Age Factors; Analgesics; Animals; Animals, Newborn; Body Temperature; Cell Proliferation; Disease Mo

2014
Psychiatric morbidity in ketamine users attending counselling and youth outreach services.
    Substance abuse, 2015, Volume: 36, Issue:1

    Topics: Adolescent; Adult; Anxiety Disorders; Comorbidity; Counseling; Depressive Disorder; Excitatory Amino

2015
[Anti-N-methyl-D-aspartate receptor encephalitis associated with ovarian teratoma: Description of a case and anesthetic implications].
    Revista espanola de anestesiologia y reanimacion, 2015, Volume: 62, Issue:8

    Topics: Adult; Anesthesia, Intravenous; Anti-N-Methyl-D-Aspartate Receptor Encephalitis; Consciousness Disor

2015
Husseini Manji.
    Nature reviews. Drug discovery, 2015, Volume: 14, Issue:11

    Topics: Antidepressive Agents; Clinical Trials, Phase III as Topic; Drug Industry; Humans; Ketamine; Male; M

2015
Previous Ketamine Produces an Enduring Blockade of Neurochemical and Behavioral Effects of Uncontrollable Stress.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2016, Jan-06, Volume: 36, Issue:1

    Topics: Anesthetics, Dissociative; Animals; Antidepressive Agents; Behavior, Animal; Chronic Disease; Ketami

2016
Transgenerational impairment of hippocampal Akt-mTOR signaling and behavioral deficits in the offspring of mice that experience postpartum depression-like illness.
    Progress in neuro-psychopharmacology & biological psychiatry, 2017, 02-06, Volume: 73

    Topics: Age Factors; Animals; Depression, Postpartum; Disease Models, Animal; Eating; Excitatory Amino Acid

2017
Effects of early or late prenatal immune activation in mice on behavioral and neuroanatomical abnormalities relevant to schizophrenia in the adulthood.
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2017, Volume: 58

    Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Brain; Disease Models, Animal; Embryo,

2017
Sublingual Ketamine for Rapid Relief of Suicidal Ideation.
    The primary care companion for CNS disorders, 2017, Mar-09, Volume: 19, Issue:2

    Topics: Administration, Sublingual; Adult; Humans; Ketamine; Male; Mental Disorders; Middle Aged; Psychotrop

2017
[Oral ketamine-midazolam premedication of uncooperative patients in major outpatient surgery].
    Revista espanola de anestesiologia y reanimacion, 2010, Volume: 57, Issue:8

    Topics: Adjuvants, Anesthesia; Administration, Oral; Ambulatory Surgical Procedures; Anesthetics, Dissociati

2010
Ketamine sedation for patients with acute agitation and psychiatric illness requiring aeromedical retrieval.
    Emergency medicine journal : EMJ, 2012, Volume: 29, Issue:4

    Topics: Acute Disease; Adolescent; Adult; Air Ambulances; Anesthetics, Dissociative; Child; Female; Humans;

2012
Gender differences in abusers of amphetamine-type stimulants and ketamine in southwestern China.
    Addictive behaviors, 2013, Volume: 38, Issue:1

    Topics: Adult; Age Factors; Amphetamine-Related Disorders; Anesthetics, Dissociative; Central Nervous System

2013
Induction of anaesthesia in the home.
    Anaesthesia and intensive care, 2002, Volume: 30, Issue:6

    Topics: Adult; Aggression; Anesthesia; Anesthetics, Dissociative; Home Care Services, Hospital-Based; Humans

2002
Neurobehavioural deficits associated with apoptotic neurodegeneration and vulnerability for ADHD.
    Neurotoxicity research, 2004, Volume: 6, Issue:6

    Topics: Animals; Animals, Newborn; Apoptosis; Attention Deficit Disorder with Hyperactivity; Central Nervous

2004
Region-specific reduction in entorhinal gamma oscillations and parvalbumin-immunoreactive neurons in animal models of psychiatric illness.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006, Mar-08, Volume: 26, Issue:10

    Topics: Animals; Disease Models, Animal; Entorhinal Cortex; Evoked Potentials; Excitatory Amino Acid Agonist

2006
Low-dose ketamine: efficacy in pediatric sedation.
    Pediatric emergency care, 2007, Volume: 23, Issue:3

    Topics: Adolescent; Atropine; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Evaluation; Dr

2007
Journey through the K-hole: phenomenological aspects of ketamine use.
    Drug and alcohol dependence, 2008, Jun-01, Volume: 95, Issue:3

    Topics: Adult; Attitude; Female; Health Status; Humans; Illicit Drugs; Ketamine; Male; Mental Disorders; Sub

2008
A comparison of the synaptic proteome in human chronic schizophrenia and rat ketamine psychosis suggest that prohibitin is involved in the synaptic pathology of schizophrenia.
    Molecular psychiatry, 2008, Volume: 13, Issue:9

    Topics: Adult; Analysis of Variance; Animals; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Elec

2008
Emotional predisposition to psychotropic drug effects.
    Journal of consulting and clinical psychology, 1977, Volume: 45, Issue:5

    Topics: Adult; Affective Symptoms; Anesthesia, Intravenous; Female; Humans; Ketamine; Mental Disorders; Midd

1977
Low frequency hearing threshold determination in newborns, infants and mentally retarded children by middle latency responses.
    Acta oto-laryngologica. Supplementum, 1991, Volume: 482

    Topics: Acoustic Stimulation; Audiometry, Evoked Response; Audiometry, Pure-Tone; Auditory Threshold; Brain

1991