Paraphimosis

A condition in which the FORESKIN, once retracted, cannot return to its original position. If this condition persists, it can lead to painful constriction of GLANS PENIS, swelling, and impaired blood flow to the penis.

Synonym
Paraphimosis

Excerpt	Reference
"Paraphimosis is a frequently presented complaint in the emergency department."	( Little, B; White, M, 2005)
"Paraphimosis is an acute condition characterized by all the signs of inflammation."	( Jayakar, SM; Rangarajan, M, 2008)
"Paraphimosis is a urologic emergency."	( Anand, A; Kapoor, S, 2013)
"Paraphimosis is an acute urological emergency occurring in uncircumcised males that can lead to strangulation of the glans and painful vascular compromise."	( Barberan Parraga, C; Cen, E; Davis, A; Dove, D; Drapkin, J; Fassassi, C; Hossain, R; Mahl, E; Motov, S; Peng, Y, 2022)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	8 (34.78)	23.3326
1990's	7 (30.43)	12.5806
2000's	4 (17.39)	18.1394
2010's	3 (13.04)	28.8240
2020's	1 (4.35)	9.53

Drug	Relationship Strength	Studies
glycerol	low	1
lidocaine	low	3
ketamine	low	1
prilocaine	low	1
prednisone	low	1
sucrose	low	2
mannitol	low	1
magnesium sulfate	low	1
cephalexin	low	1
triamcinolone	low	1
psd 502	low	1
caseins	low	1
hyaluronoglucosaminidase	low	8

Protein Targets (143)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	2	0	0	2
Chain A, Putative fructose-1,6-bisphosphate aldolase	1	0	0	1
phosphopantetheinyl transferase	1	0	0	1
TDP1 protein	3	0	0	3
Microtubule-associated protein tau	2	0	0	2
aldehyde dehydrogenase 1 family, member A1	4	0	0	4
glucocorticoid receptor [Homo sapiens]	4	0	0	4
bromodomain adjacent to zinc finger domain 2B	1	0	0	1
euchromatic histone-lysine N-methyltransferase 2	4	0	0	4
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	1	0	0	1
vitamin D3 receptor isoform VDRA	2	0	0	2
mitogen-activated protein kinase 1	2	0	0	2
nuclear factor erythroid 2-related factor 2 isoform 1	5	0	0	5
Solute carrier family 22 member 6	0	2	0	2
Interferon beta	2	0	0	2
Solute carrier family 15 member 1	0	2	0	2
Solute carrier family 15 member 1	0	1	0	1
B2 metallo-beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	1	0	1
Solute carrier family 15 member 2	0	1	0	2
Solute carrier family 22 member 8	0	1	0	1
Chain B, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E	0	0	1	1
GLI family zinc finger 3	4	0	0	4
AR protein	5	0	0	5
retinoic acid nuclear receptor alpha variant 1	2	0	0	2
retinoid X nuclear receptor alpha	2	0	0	2
estrogen nuclear receptor alpha	5	0	0	5
peroxisome proliferator-activated receptor delta	1	0	0	1
activating transcription factor 6	2	0	0	2
thyroid hormone receptor beta isoform a	1	0	0	1
thyroid hormone receptor beta isoform 2	2	0	0	2
lamin isoform A-delta10	5	0	0	5
Cellular tumor antigen p53	3	0	0	3
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	2	0	0	2
cytochrome P450 family 3 subfamily A polypeptide 4	1	0	0	1
pregnane X nuclear receptor	4	0	0	4
chromobox protein homolog 1	4	0	0	4
geminin	4	0	0	4
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
ATP-binding cassette sub-family C member 3	0	2	0	2
Multidrug resistance-associated protein 4	0	2	0	2
Acetylcholinesterase	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Bile salt export pump	0	2	0	2
Rap guanine nucleotide exchange factor 3	1	0	0	1
Glutamate receptor ionotropic, NMDA 1	0	2	0	2
Sodium channel protein type 4 subunit alpha	0	2	0	2
Cholinesterase	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	2	0	2
Glutamate receptor ionotropic, NMDA 2B	0	2	0	2
Glutamate receptor ionotropic, NMDA 2C	0	2	0	2
Glutamate receptor ionotropic, NMDA 1	0	2	0	2
Glutamate receptor ionotropic, NMDA 2A	0	2	0	2
Glutamate receptor ionotropic, NMDA 2B	0	2	0	2
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Glutamate receptor ionotropic, NMDA 2D	0	2	0	2
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	2	0	2
Canalicular multispecific organic anion transporter 1	0	2	0	2
Glutamate receptor ionotropic, NMDA 3A	0	2	0	2
Chain A, Beta-lactamase	1	0	0	1
thioredoxin reductase	2	0	0	2
RAR-related orphan receptor gamma	2	0	0	2
GLS protein	1	0	0	1
vitamin D (1,25- dihydroxyvitamin D3) receptor	2	0	0	2
IDH1	1	0	0	1
flap endonuclease 1	1	0	0	1
cytochrome P450 3A4 isoform 1	2	0	0	2
muscarinic acetylcholine receptor M1	1	0	0	1
Gamma-aminobutyric acid receptor subunit pi	2	0	0	2
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 2	0	1	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	2	0	0	2
Gamma-aminobutyric acid receptor subunit delta	2	0	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-5	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	2	0	0	2
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	2	0	0	2
Gamma-aminobutyric acid receptor subunit gamma-3	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-6	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	2	0	0	2
Gamma-aminobutyric acid receptor subunit beta-3	2	0	0	2
Gamma-aminobutyric acid receptor subunit beta-2	2	0	0	2
Potassium voltage-gated channel subfamily H member 2	0	1	0	1
Sodium channel protein type 5 subunit alpha	0	1	0	1
Sodium channel protein type 9 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily D member 2	0	1	0	1
Potassium channel subfamily K member 18	0	1	0	1
GABA theta subunit	2	0	0	2
Multidrug and toxin extrusion protein 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	2	0	0	2
Sodium channel protein type 3 subunit alpha	0	1	0	1
USP1 protein, partial	1	0	0	1
estrogen receptor 2 (ER beta)	2	0	0	2
estrogen-related nuclear receptor alpha	3	0	0	3
potassium voltage-gated channel subfamily H member 2 isoform d	1	0	0	1
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
TAR DNA-binding protein 43	1	0	0	1
Chain A, HADH2 protein	2	0	0	2
Chain B, HADH2 protein	2	0	0	2
pregnane X receptor	1	0	0	1
thioredoxin glutathione reductase	2	0	0	2
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	2	0	0	2
nuclear receptor subfamily 1, group I, member 3	1	0	0	1
progesterone receptor	2	0	0	2
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	2	0	0	2
v-jun sarcoma virus 17 oncogene homolog (avian)	1	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 2	2	0	0	2
nuclear receptor ROR-gamma isoform 1	1	0	0	1
Glucocorticoid receptor	0	4	1	5
Glycine receptor subunit alpha-1	0	4	0	4
Glycine receptor subunit beta	0	4	0	4
Glycine receptor subunit alpha-2	0	4	0	4
Glycine receptor subunit alpha-3	0	4	0	4
Nuclear receptor ROR-gamma	1	0	0	1
cytochrome P450 2D6	1	0	0	1
arylsulfatase A	2	0	0	2
Chain A, MALTOPORIN	0	0	1	1
Chain B, MALTOPORIN	0	0	1	1
peripheral myelin protein 22	1	0	0	1
Carbonic anhydrase 2	0	1	1	2
Carbonic anhydrase 9	0	1	1	2
glp-1 receptor, partial	1	0	0	1
SMAD family member 2	1	0	0	1
ATAD5 protein, partial	1	0	0	1
NFKB1 protein, partial	1	0	0	1
SMAD family member 3	1	0	0	1
Smad3	1	0	0	1
Bloom syndrome protein isoform 1	1	0	0	1
peripheral myelin protein 22 isoform 1	1	0	0	1
heat shock protein beta-1	1	0	0	1
procathepsin L isoform 1 preproprotein	0	1	0	1
muscleblind-like protein 1 isoform 1	1	0	0	1
Cytochrome P450 2C9	0	1	0	1
Cytochrome P450 2J2	0	1	0	1
ATPase family AAA domain-containing protein 5	1	0	0	1
Ataxin-2	1	0	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(1)

Research Excerpts

Overview

Research

Studies (23)

Protein Targets (143)

Paraphimosis

Synonyms(1)

Research Excerpts

Overview

Research

Studies (23)

Drugs Studied (16)

Protein Targets (143)