Page last updated: 2024-10-29

ketamine and Erythermalgia

ketamine has been researched along with Erythermalgia in 7 studies

Ketamine: A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.
ketamine : A member of the class of cyclohexanones in which one of the hydrogens at position 2 is substituted by a 2-chlorophenyl group, while the other is substituted by a methylamino group.

Research Excerpts

ExcerptRelevanceReference
"We retrospectively evaluated 36 patients with erythromelalgia who were treated with compounded topical amitriptyline-ketamine from January 1, 2004, through January 31, 2011."7.79Topical amitriptyline combined with ketamine for the treatment of erythromelalgia: a retrospective study of 36 patients at Mayo Clinic. ( Davis, MD; Murphy, SL; Poterucha, TJ; Rho, RH; Sandroni, P; Warndahl, RA; Weiss, WT, 2013)
"Erythromelalgia is a rare neurovascular pain condition characterized by erythematous, warm, and painful extremities."5.72Intravenous Ketamine Infusion as an Adjunctive Pain Treatment for Erythromelalgia: A Pediatric Case Report. ( Adams, AC; Montoya, L; Popenhagen, MP; Price, HN; Russi, DC; Singhal, NR, 2022)
"We retrospectively evaluated 36 patients with erythromelalgia who were treated with compounded topical amitriptyline-ketamine from January 1, 2004, through January 31, 2011."3.79Topical amitriptyline combined with ketamine for the treatment of erythromelalgia: a retrospective study of 36 patients at Mayo Clinic. ( Davis, MD; Murphy, SL; Poterucha, TJ; Rho, RH; Sandroni, P; Warndahl, RA; Weiss, WT, 2013)
"Erythromelalgia is a rare neurovascular pain condition characterized by erythematous, warm, and painful extremities."1.72Intravenous Ketamine Infusion as an Adjunctive Pain Treatment for Erythromelalgia: A Pediatric Case Report. ( Adams, AC; Montoya, L; Popenhagen, MP; Price, HN; Russi, DC; Singhal, NR, 2022)
"Erythromelalgia is characterized by episodes of erythematous, warm, burning acral skin, which is exacerbated by heat and relieved by cold."1.35Erythromelalgia of the ears: an unusual variant and response to therapy. ( Berk, DR; Eisen, AZ, 2008)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (57.14)29.6817
2010's1 (14.29)24.3611
2020's2 (28.57)2.80

Authors

AuthorsStudies
Montoya, L1
Adams, AC1
Popenhagen, MP1
Russi, DC1
Singhal, NR1
Price, HN1
Portugal, F1
Araújo, A1
Silva, C1
Campos, M1
Valentim, A1
Poterucha, TJ1
Weiss, WT1
Warndahl, RA1
Rho, RH1
Sandroni, P2
Davis, MD2
Murphy, SL1
Uchida, K1
Arita, H1
Hanaoka, K1
Cohen, JS1
Berk, DR1
Eisen, AZ1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Antipruritic Effect of Topical Ketamine, Amitriptyline, and Lidocaine[NCT03096444]Phase 213 participants (Actual)Interventional2017-05-23Terminated (stopped due to Efficacy was not seen after interim analysis)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Peak Itch Intensity Between the Vehicle and Active Treatments (Individual and KeAmLi-combo).

"Peak itch intensity between the vehicle and 4 other active treatments (individual ketamine, amitriptyline, or lidocaine, and KeAmLi-combo). Itch intensity was measured on a 100mm scale visual analog scale for 10 minutes. 0 was weighted with no itch and 100 was weighted with most itch imaginable." (NCT03096444)
Timeframe: 10 minutes

InterventionIntensity score (Mean)
Topical KeAmLi Combo62.7
Topical Ketamine63.1
Topical Amitriptyline69.2
Topical Lidocaine65.8
Topical Vehicle61.9

Mechanical Thresholds (Mechanical Detection and Pain).

Assess mechanical detection and pain thresholds using von Frey filaments stimulators (measured in force mN) to calculate the final threshold as the geometric mean of five series of ascending and descending stimuli. (NCT03096444)
Timeframe: 5 minutes

,,,,
InterventionmN (Mean)
Mechanical Detection ThresholdMechanical Pain Threshold
Topical Amitriptyline3.573423965152.4768146
Topical KeAmLi Combo3.519376956152.3293608
Topical Ketamine3.464204768135.9
Topical Lidocaine3.546037659126.9
Topical Vehicle3.525692637148.7138273

Thermal Threshold Detection (Warmth and Heat Pain)

Two standardized quantitative sensory tests are performed to measure warmth detection threshold (assesses the threshold of which warmth sensation is first detected) and heat pain threshold (assesses the threshold at which heat pain sensation is first detected). Measured in change in celsius. (NCT03096444)
Timeframe: 3 minutes

,,,,
InterventionDegrees celsius (Mean)
Warm Detection ThresholdHeat Pain Threshold
Topical Amitriptyline33.940.0
Topical KeAmLi Combo33.639.8
Topical Ketamine34.040.0
Topical Lidocaine33.739.4
Topical Vehicle33.839.7

Other Studies

7 other studies available for ketamine and Erythermalgia

ArticleYear
Intravenous Ketamine Infusion as an Adjunctive Pain Treatment for Erythromelalgia: A Pediatric Case Report.
    A&A practice, 2022, Apr-13, Volume: 16, Issue:4

    Topics: Analgesics; Child; Erythromelalgia; Female; Humans; Ketamine; Pain; Pain Management

2022
Combination gel of 2% amitriptyline and 0.5% ketamine to treat refractory erythromelalgia pain - a case report of pain control success.
    Revista espanola de anestesiologia y reanimacion, 2021, Volume: 68, Issue:5

    Topics: Amitriptyline; Analgesics; Drug Combinations; Erythromelalgia; Humans; Ketamine; Male; Pain Manageme

2021
Topical amitriptyline combined with ketamine for the treatment of erythromelalgia: a retrospective study of 36 patients at Mayo Clinic.
    Journal of drugs in dermatology : JDD, 2013, Volume: 12, Issue:3

    Topics: Administration, Cutaneous; Adolescent; Adult; Aged; Amitriptyline; Analgesics; Analgesics, Non-Narco

2013
[Successful intravenous administration of low dose ketamine for pain caused by erythromelalgia: report of a case].
    Masui. The Japanese journal of anesthesiology, 2002, Volume: 51, Issue:11

    Topics: Adolescent; Analgesics; Dose-Response Relationship, Drug; Drug Administration Schedule; Erythromelal

2002
Combination gel of 1% amitriptyline and 0.5% ketamine to treat refractory erythromelalgia pain: a new treatment option?
    Archives of dermatology, 2006, Volume: 142, Issue:3

    Topics: Adolescent; Amitriptyline; Analgesics; Antidepressive Agents, Tricyclic; Drug Combinations; Erythrom

2006
Transdermal therapy for erythromelalgia.
    Archives of dermatology, 2006, Volume: 142, Issue:11

    Topics: Administration, Cutaneous; Amitriptyline; Analgesics; Drug Therapy, Combination; Erythromelalgia; Hu

2006
Erythromelalgia of the ears: an unusual variant and response to therapy.
    Journal of drugs in dermatology : JDD, 2008, Volume: 7, Issue:3

    Topics: Administration, Oral; Aged; Amitriptyline; Analgesics; Drug Combinations; Ear; Ear Diseases; Erythro

2008