ketamine has been researched along with Phantom Limb in 14 studies
Ketamine: A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.
ketamine : A member of the class of cyclohexanones in which one of the hydrogens at position 2 is substituted by a 2-chlorophenyl group, while the other is substituted by a methylamino group.
Phantom Limb: Perception of painful and nonpainful phantom sensations that occur following the complete or partial loss of a limb. The majority of individuals with an amputated extremity will experience the impression that the limb is still present, and in many cases, painful. (From Neurol Clin 1998 Nov;16(4):919-36; Brain 1998 Sep;121(Pt 9):1603-30)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Ketamine, but not calcitonin, reduced phantom limb pain." | 9.13 | Chronic phantom limb pain: the effects of calcitonin, ketamine, and their combination on pain and sensory thresholds. ( Arendt-Nielsen, L; Björgo, S; Curatolo, M; Eichenberger, U; Neff, F; Petersen-Felix, S; Sveticic, G, 2008) |
| "Three cases are described in which phantom limb pain was successfully treated with ketamine hydrochloride." | 7.68 | Ketamine hydrochloride in the treatment of phantom limb pain. ( Porter, GE; Stannard, CF, 1993) |
| "Neuropathic pain has been shown to respond to drugs that block the N-methyl-D-aspartate (NMDA) receptor, such as ketamine and amantidine." | 5.31 | An unusual case of chronic neuropathic pain responds to an optimum frequency of intravenous ketamine infusions. ( Mitchell, AC, 2001) |
| "Ketamine, but not calcitonin, reduced phantom limb pain." | 5.13 | Chronic phantom limb pain: the effects of calcitonin, ketamine, and their combination on pain and sensory thresholds. ( Arendt-Nielsen, L; Björgo, S; Curatolo, M; Eichenberger, U; Neff, F; Petersen-Felix, S; Sveticic, G, 2008) |
| "We hypothesized that perioperative ketamine administration would modify acute central sensitization following amputation and hence reduce the incidence and severity of persistent post-amputation pain (both phantom limb and stump pain)." | 5.11 | Perioperative intravenous ketamine infusion for the prevention of persistent post-amputation pain: a randomized, controlled trial. ( Armstrong-Brown, A; Burstal, R; Hayes, C, 2004) |
| "The prevalences of complex regional pain syndrome, phantom limb pain, chronic donor-site pain, and persistent pain following total joint arthroplasty are alarmingly high." | 2.44 | Preventing the development of chronic pain after orthopaedic surgery with preventive multimodal analgesic techniques. ( Buvanendran, A; Reuben, SS, 2007) |
| "Neuropathic pain has been shown to respond to drugs that block the N-methyl-D-aspartate (NMDA) receptor, such as ketamine and amantidine." | 1.31 | An unusual case of chronic neuropathic pain responds to an optimum frequency of intravenous ketamine infusions. ( Mitchell, AC, 2001) |
| "A case of phantom limb pain, which had not successfully responded to a long list of medical therapy or neurosurgery, is presented." | 1.29 | [Ketamine in the management of intractable phantom pain]. ( Borgbjerg, FM; Franks, JF; Mikkelsen, SS; Olesen, AS, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (42.86) | 18.2507 |
| 2000's | 6 (42.86) | 29.6817 |
| 2010's | 2 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bornemann-Cimenti, H | 1 |
| Dorn, C | 1 |
| Rumpold-Seitlinger, G | 1 |
| Sakai, T | 1 |
| Sumikawa, K | 1 |
| Hayes, C | 1 |
| Armstrong-Brown, A | 1 |
| Burstal, R | 1 |
| Ben-Ari, A | 1 |
| Lewis, MC | 1 |
| Davidson, E | 1 |
| Reuben, SS | 1 |
| Buvanendran, A | 1 |
| Wilson, JA | 1 |
| Nimmo, AF | 1 |
| Fleetwood-Walker, SM | 1 |
| Colvin, LA | 1 |
| Eichenberger, U | 1 |
| Neff, F | 1 |
| Sveticic, G | 1 |
| Björgo, S | 1 |
| Petersen-Felix, S | 1 |
| Arendt-Nielsen, L | 2 |
| Curatolo, M | 1 |
| Franks, JF | 1 |
| Olesen, AS | 1 |
| Mikkelsen, SS | 1 |
| Borgbjerg, FM | 1 |
| Stannard, CF | 1 |
| Porter, GE | 1 |
| Hansen, G | 1 |
| Knox, DJ | 1 |
| McLeod, BJ | 1 |
| Goucke, CR | 1 |
| Nikolajsen, L | 1 |
| Hansen, CL | 1 |
| Nielsen, J | 1 |
| Keller, J | 1 |
| Jensen, TS | 1 |
| Baylis, R | 1 |
| Stannard, C | 1 |
| Mitchell, AC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Double Blind, Randomized, Placebo Controlled Clinical Trial to Evaluate the Efficacy of Repetitive Transcranial Magnetic Stimulation in Patients Victims of Landmines With Phantom Limb Pain[NCT01872481] | Phase 3 | 54 participants (Actual) | Interventional | 2013-06-30 | Completed | ||
| Study of the Efficiency of the Ketamine With Low Analgesic Doses, in Association With High Opioids, in the Treatment of the Rebels Pains, in Palliative Phase of the Cancerous Disease[NCT01326325] | Phase 3 | 24 participants (Actual) | Interventional | 2011-07-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for ketamine and Phantom Limb
| Article | Year |
|---|---|
Chronic administration of ketamine for analgesia.
Topics: Analgesics; Animals; Chronic Disease; Humans; Ketamine; Neoplasms; Pain, Intractable; Peripheral Ner | 2007 |
Preventing the development of chronic pain after orthopaedic surgery with preventive multimodal analgesic techniques.
Topics: Acetaminophen; Adrenergic alpha-Agonists; Analgesia, Epidural; Analgesics; Anesthetics, Local; Anima | 2007 |
4 trials available for ketamine and Phantom Limb
| Article | Year |
|---|---|
Perioperative intravenous ketamine infusion for the prevention of persistent post-amputation pain: a randomized, controlled trial.
Topics: Aged; Amputation, Surgical; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Anesthesi | 2004 |
A randomised double blind trial of the effect of pre-emptive epidural ketamine on persistent pain after lower limb amputation.
Topics: Aged; Amputation, Surgical; Analgesia, Epidural; Analgesics; Analysis of Variance; Double-Blind Meth | 2008 |
Chronic phantom limb pain: the effects of calcitonin, ketamine, and their combination on pain and sensory thresholds.
Topics: Analgesics; Calcitonin; Computers; Cross-Over Studies; Double-Blind Method; Drug Therapy, Combinatio | 2008 |
The effect of ketamine on phantom pain: a central neuropathic disorder maintained by peripheral input.
Topics: Adult; Afferent Pathways; Aged; Amputation Stumps; Brain; Female; Hot Temperature; Humans; Ketamine; | 1996 |
8 other studies available for ketamine and Phantom Limb
| Article | Year |
|---|---|
Early Onset and Treatment of Phantom Limb Pain Following Surgical Amputation.
Topics: Aged; Amputation, Surgical; Analgesics; Anesthetics, Local; Calcitonin; Early Medical Intervention; | 2017 |
Phantom limb pain exacerbated by intravenous ketamine.
Topics: Anesthesia, Intravenous; Anesthetics, Dissociative; Hallucinations; Humans; Infusions, Intravenous; | 2014 |
[Ketamine in the management of intractable phantom pain].
Topics: Administration, Oral; Amputation, Surgical; Female; Forearm; Humans; Ketamine; Middle Aged; Pain, In | 1995 |
Ketamine hydrochloride in the treatment of phantom limb pain.
Topics: Adult; Amputation, Surgical; Arm; Female; Humans; Ketamine; Leg; Male; Middle Aged; Phantom Limb | 1993 |
[Ketamine and phantom pain].
Topics: Anesthetics, Dissociative; Humans; Ketamine; Nociceptors; Pain; Phantom Limb | 1995 |
Acute phantom limb pain controlled by ketamine.
Topics: Acute Disease; Adolescent; Anesthetics, Dissociative; Humans; Infusions, Intravenous; Ketamine; Male | 1995 |
Phantom limb pain.
Topics: Adolescent; Analgesics; Anesthetics, Dissociative; Humans; Ketamine; Nociceptors; Pain; Phantom Limb | 1996 |
An unusual case of chronic neuropathic pain responds to an optimum frequency of intravenous ketamine infusions.
Topics: Adult; Chronic Disease; Excitatory Amino Acid Antagonists; Female; Humans; Ketamine; Pain; Phantom L | 2001 |