ketamine has been researched along with Altered Level of Consciousness in 9 studies
Ketamine: A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.
ketamine : A member of the class of cyclohexanones in which one of the hydrogens at position 2 is substituted by a 2-chlorophenyl group, while the other is substituted by a methylamino group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Schizophrenia is one of the common mental diseases." | 2.45 | [Receptor antagonist of NMDA and animal models of schizophrenia]. ( Bian, SZ; Gu, ZL; Jiang, XG; Liu, WL; Sun, ZH; Zhang, J, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (33.33) | 29.6817 |
| 2010's | 6 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lee, CW | 1 |
| Chao, YY | 1 |
| Shiea, J | 1 |
| Shen, JH | 1 |
| Lee, HH | 1 |
| Chen, BH | 1 |
| Vlisides, PE | 1 |
| Bel-Bahar, T | 1 |
| Nelson, A | 1 |
| Chilton, K | 1 |
| Smith, E | 1 |
| Janke, E | 1 |
| Tarnal, V | 1 |
| Picton, P | 1 |
| Harris, RE | 1 |
| Mashour, GA | 1 |
| Tang, MHY | 1 |
| Chong, YK | 1 |
| Chan, CY | 1 |
| Ching, CK | 1 |
| Lai, CK | 1 |
| Li, YK | 1 |
| Mak, TWL | 1 |
| Finley, J | 1 |
| Sullivan, RW | 1 |
| Ryzewski, M | 1 |
| Holland, MG | 1 |
| Marraffa, JM | 1 |
| Arteche Andrés, MA | 1 |
| Zugasti Echarte, O | 1 |
| de Carlos Errea, J | 1 |
| Pérez Rodríguez, M | 1 |
| Leyún Pérez de Zabalza, R | 1 |
| Azcona Calahorra, MA | 1 |
| Bueno, AM | 1 |
| Tena, B | 1 |
| Ubré, M | 1 |
| Gomar, C | 1 |
| Bian, SZ | 1 |
| Zhang, J | 1 |
| Liu, WL | 1 |
| Sun, ZH | 1 |
| Gu, ZL | 1 |
| Jiang, XG | 1 |
| Northoff, G | 1 |
| Richter, A | 1 |
| Bermpohl, F | 1 |
| Grimm, S | 1 |
| Martin, E | 1 |
| Marcar, VL | 1 |
| Wahl, C | 1 |
| Hell, D | 1 |
| Boeker, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Antipruritic Effect of Topical Ketamine, Amitriptyline, and Lidocaine[NCT03096444] | Phase 2 | 13 participants (Actual) | Interventional | 2017-05-23 | Terminated (stopped due to Efficacy was not seen after interim analysis) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Peak itch intensity between the vehicle and 4 other active treatments (individual ketamine, amitriptyline, or lidocaine, and KeAmLi-combo). Itch intensity was measured on a 100mm scale visual analog scale for 10 minutes. 0 was weighted with no itch and 100 was weighted with most itch imaginable." (NCT03096444)
Timeframe: 10 minutes
| Intervention | Intensity score (Mean) |
|---|---|
| Topical KeAmLi Combo | 62.7 |
| Topical Ketamine | 63.1 |
| Topical Amitriptyline | 69.2 |
| Topical Lidocaine | 65.8 |
| Topical Vehicle | 61.9 |
Assess mechanical detection and pain thresholds using von Frey filaments stimulators (measured in force mN) to calculate the final threshold as the geometric mean of five series of ascending and descending stimuli. (NCT03096444)
Timeframe: 5 minutes
| Intervention | mN (Mean) | |
|---|---|---|
| Mechanical Detection Threshold | Mechanical Pain Threshold | |
| Topical Amitriptyline | 3.573423965 | 152.4768146 |
| Topical KeAmLi Combo | 3.519376956 | 152.3293608 |
| Topical Ketamine | 3.464204768 | 135.9 |
| Topical Lidocaine | 3.546037659 | 126.9 |
| Topical Vehicle | 3.525692637 | 148.7138273 |
Two standardized quantitative sensory tests are performed to measure warmth detection threshold (assesses the threshold of which warmth sensation is first detected) and heat pain threshold (assesses the threshold at which heat pain sensation is first detected). Measured in change in celsius. (NCT03096444)
Timeframe: 3 minutes
| Intervention | Degrees celsius (Mean) | |
|---|---|---|
| Warm Detection Threshold | Heat Pain Threshold | |
| Topical Amitriptyline | 33.9 | 40.0 |
| Topical KeAmLi Combo | 33.6 | 39.8 |
| Topical Ketamine | 34.0 | 40.0 |
| Topical Lidocaine | 33.7 | 39.4 |
| Topical Vehicle | 33.8 | 39.7 |
1 review available for ketamine and Altered Level of Consciousness
| Article | Year |
|---|---|
[Receptor antagonist of NMDA and animal models of schizophrenia].
Topics: Animals; Behavior, Animal; Brain; Consciousness Disorders; Disease Models, Animal; Dizocilpine Malea | 2009 |
1 trial available for ketamine and Altered Level of Consciousness
| Article | Year |
|---|---|
NMDA hypofunction in the posterior cingulate as a model for schizophrenia: an exploratory ketamine administration study in fMRI.
Topics: Adult; Consciousness Disorders; Double-Blind Method; Excitatory Amino Acid Antagonists; Female; Gyru | 2005 |
7 other studies available for ketamine and Altered Level of Consciousness
| Article | Year |
|---|---|
Ambient mass spectrometry for rapid diagnosis of psychoactive drugs overdose in an unstable patient.
Topics: 3,4-Methylenedioxyamphetamine; Adult; Consciousness Disorders; Drug Overdose; Emergency Service, Hos | 2018 |
Subanaesthetic ketamine and altered states of consciousness in humans.
Topics: Adult; Alpha Rhythm; Anesthesia; Anesthetics, Dissociative; Brain; Brain Mapping; Consciousness Diso | 2018 |
Cluster of acute poisonings associated with an emerging ketamine analogue, 2-oxo-PCE.
Topics: Adult; Chromatography, Liquid; Confusion; Consciousness Disorders; Female; Forensic Toxicology; Gas | 2018 |
Cellular stress and AMPK links metformin and diverse compounds with accelerated emergence from anesthesia and potential recovery from disorders of consciousness.
Topics: AMP-Activated Protein Kinases; Anesthesia; Anesthesia Recovery Period; Anesthetics; Animals; Brain M | 2019 |
Compounded ointment results in severe toxicity in a pediatric patient.
Topics: Administration, Cutaneous; Amines; Analgesics; Body Surface Area; Bradycardia; Clonidine; Combined M | 2013 |
[Anti-N-methyl-D-aspartate receptor encephalitis associated with ovarian teratoma: Description of a case and anesthetic implications].
Topics: Adult; Anesthesia, Intravenous; Anti-N-Methyl-D-Aspartate Receptor Encephalitis; Consciousness Disor | 2015 |
[Incident involving the prescription of ketamine outside the operating room].
Topics: Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics; Anesthetics, Local; Carcinoma; Consc | 2009 |