ketamine has been researched along with Cancer Pain in 24 studies
Ketamine: A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.
ketamine : A member of the class of cyclohexanones in which one of the hydrogens at position 2 is substituted by a 2-chlorophenyl group, while the other is substituted by a methylamino group.
Cancer Pain: Pain that may be caused by or related to cellular, tissue, and systemic changes that occur during NEOPLASM growth, tissue invasion, and METASTASIS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In conclusion, we confirmed that just as morphine, ketamine dose-dependently suppressed IL-2 and IFN-γ of activated T lymphocyte of patients with refractory cancer pain in vitro, but the inhibitory action of low dose ketamine could be neglected." | 9.24 | Ketamine, as adjuvant analgesics for patients with refractory cancer pain, does affect IL-2/IFN-γ expression of T cells in vitro?: A prospective, randomized, double-blind study. ( Fu, Z; Li, H; Wang, K; Zhou, N, 2017) |
| "To determine the effectiveness and adverse effects of ketamine as an adjuvant to opioids for refractory cancer pain in adults." | 8.95 | Ketamine as an adjuvant to opioids for cancer pain. ( Bell, RF; Eccleston, C; Kalso, EA, 2017) |
| "While randomized controlled trials consistently show lack of clinical efficacy of ketamine in treating cancer pain, a large number of open-label studies and case series show benefit." | 8.95 | Ketamine for cancer pain: what is the evidence? ( Dahan, A; Jonkman, K; van de Donk, T, 2017) |
| "Following recognition of opioid induced hyperalgesia, the patient was managed with opioid rotation and ketamine, which resulted in prompt alleviation of pain." | 8.12 | Role of Ketamine and Opioid Rotation in the Management of Opioid Induced Hyperalgesia in a Patient With Acute Promyelocytic Leukemia. ( Akhtari, M; Cao, H; Hino, C; Ran-Castillo, D; Silvestre, J, 2022) |
| "The objective of our study was to determine safety and pharmacology (pharmacokinetics and preliminary efficacy) of intranasal (IN) ketamine for uncontrolled cancer-related pain." | 8.12 | A dose-escalation clinical trial of intranasal ketamine for uncontrolled cancer-related pain. ( Beumer, JH; Curseen, K; Egan, K; Gillespie, TW; Harvey, RD; Lane, O; Shteamer, JW; Singh, V; Sniecinski, R; Spektor, B; Switchenko, J; Tsvetkova, M; Zarrabi, AJ, 2022) |
| "These data demonstrated the efficacy and safety of ketamine in a population of patients with refractory cancer pain." | 7.96 | The use of ketamine in the management of refractory cancer pain in a palliative care unit. ( Chan, PC; Cheung, KWA; Lo, SH, 2020) |
| "Ketamine has shown promise as an effective adjuvant despite conflicting reports." | 5.62 | Subanesthetic ketamine in the ambulatory setting for refractory cancer pain: a 6-year retrospective at a cancer center. ( Benkli, B; Chung, M; Huh, B; Qing, Y; Roldan, C; Wang, J, 2021) |
| "Opioid-induced hyperalgesia is a paradoxical adverse effect of opioid therapy with unclear strategies for its treatment and management." | 5.48 | The Enigma of Low-Dose Ketamine for Treatment of Opioid-Induced Hyperalgesia in the Setting of Psychosocial Suffering and Cancer-Associated Pain. ( Atayee, RS; Mesarwi, P; Willeford, A; Winters, KD, 2018) |
| "In conclusion, we confirmed that just as morphine, ketamine dose-dependently suppressed IL-2 and IFN-γ of activated T lymphocyte of patients with refractory cancer pain in vitro, but the inhibitory action of low dose ketamine could be neglected." | 5.24 | Ketamine, as adjuvant analgesics for patients with refractory cancer pain, does affect IL-2/IFN-γ expression of T cells in vitro?: A prospective, randomized, double-blind study. ( Fu, Z; Li, H; Wang, K; Zhou, N, 2017) |
| "To determine the effectiveness and adverse effects of ketamine as an adjuvant to opioids for refractory cancer pain in adults." | 4.95 | Ketamine as an adjuvant to opioids for cancer pain. ( Bell, RF; Eccleston, C; Kalso, EA, 2017) |
| "While randomized controlled trials consistently show lack of clinical efficacy of ketamine in treating cancer pain, a large number of open-label studies and case series show benefit." | 4.95 | Ketamine for cancer pain: what is the evidence? ( Dahan, A; Jonkman, K; van de Donk, T, 2017) |
| "Following recognition of opioid induced hyperalgesia, the patient was managed with opioid rotation and ketamine, which resulted in prompt alleviation of pain." | 4.12 | Role of Ketamine and Opioid Rotation in the Management of Opioid Induced Hyperalgesia in a Patient With Acute Promyelocytic Leukemia. ( Akhtari, M; Cao, H; Hino, C; Ran-Castillo, D; Silvestre, J, 2022) |
| "The objective of our study was to determine safety and pharmacology (pharmacokinetics and preliminary efficacy) of intranasal (IN) ketamine for uncontrolled cancer-related pain." | 4.12 | A dose-escalation clinical trial of intranasal ketamine for uncontrolled cancer-related pain. ( Beumer, JH; Curseen, K; Egan, K; Gillespie, TW; Harvey, RD; Lane, O; Shteamer, JW; Singh, V; Sniecinski, R; Spektor, B; Switchenko, J; Tsvetkova, M; Zarrabi, AJ, 2022) |
| "This prospective, multicentre, observational trial collected data regarding demographics, pain characteristics, pain score assessment within the first 48 hours of ketamine administration, tolerance and satisfaction from 38 patients aged 2-24 years prescribed with ketamine as an adjuvant antalgic for refractory cancer pain in 10 French paediatric oncology centres." | 4.12 | Low-dose ketamine adjuvant treatment for refractory pain in children, adolescents and young adults with cancer: a pilot study. ( Bertrand, A; Cojean, N; Courade, M; Dugue, S; Guerrini-Rousseau, L; Lervat, C; Levy, D; Marec-Berard, P; Pagnier, A; Piguet, C; Ribrault, A; Schmitt, C; Thouvenin, S, 2022) |
| "These data demonstrated the efficacy and safety of ketamine in a population of patients with refractory cancer pain." | 3.96 | The use of ketamine in the management of refractory cancer pain in a palliative care unit. ( Chan, PC; Cheung, KWA; Lo, SH, 2020) |
| "Among children on cancer chemotherapy with severe OM, ketamine mouthwash at a dose of 1 mg/kg did not significantly reduce OM pain." | 2.94 | Ketamine mouthwash versus placebo in the treatment of severe oral mucositis pain in children with cancer: A randomized double-blind placebo-controlled trial. ( Bakhshi, S; Gupta, AK; Meena, JP; Pandey, RM; Prakash, S; Seth, R; Velpandian, T, 2020) |
| " Oral bioavailability is low and erratic, limiting application of this route for chronic use." | 2.58 | Intranasal Ketamine and Its Potential Role in Cancer-Related Pain. ( Gillespie, TW; Harvey, RD; Singh, V, 2018) |
| "Chronic postsurgical pain (CPSP) is an important and well recognized cause of much long-term suffering, which in some cases may be preventable and affects many people living with cancer." | 2.58 | Chronic postsurgical pain and cancer: the catch of surviving the unsurvivable. ( Bhaskar, A; Humble, SR; Jayaweera, A; Varela, N, 2018) |
| "Ketamine has shown promise as an effective adjuvant despite conflicting reports." | 1.62 | Subanesthetic ketamine in the ambulatory setting for refractory cancer pain: a 6-year retrospective at a cancer center. ( Benkli, B; Chung, M; Huh, B; Qing, Y; Roldan, C; Wang, J, 2021) |
| "For severe cancer-related pain that is not relieved adequately by escalating doses of oral or parenterally administered strong opioid analgesics such as morphine, alone or in combination with an adjuvant drug such as ketamine, more invasive dosing routes may be warranted." | 1.51 | Bioerodable Ketamine-Loaded Microparticles Fabricated Using Dissolvable Hydrogel Template Technology. ( Han, FY; Smith, MT; Whittaker, AK; Zhu, M, 2019) |
| "Opioid-induced hyperalgesia is a paradoxical adverse effect of opioid therapy with unclear strategies for its treatment and management." | 1.48 | The Enigma of Low-Dose Ketamine for Treatment of Opioid-Induced Hyperalgesia in the Setting of Psychosocial Suffering and Cancer-Associated Pain. ( Atayee, RS; Mesarwi, P; Willeford, A; Winters, KD, 2018) |
| "Pain is a significant side effect of disease, surgery and treatments including chemotherapy." | 1.43 | Pain management for chemotherapy-induced oral mucositis. ( Bennett, M, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 15 (62.50) | 24.3611 |
| 2020's | 9 (37.50) | 2.80 |
| Authors | Studies |
|---|---|
| Hino, C | 1 |
| Ran-Castillo, D | 1 |
| Akhtari, M | 1 |
| Cao, H | 1 |
| Silvestre, J | 1 |
| Forth, N | 1 |
| Nguyen, M | 1 |
| Grech, A | 1 |
| Singh, V | 2 |
| Gillespie, TW | 2 |
| Lane, O | 1 |
| Spektor, B | 1 |
| Zarrabi, AJ | 1 |
| Egan, K | 1 |
| Curseen, K | 1 |
| Tsvetkova, M | 1 |
| Beumer, JH | 1 |
| Sniecinski, R | 1 |
| Shteamer, JW | 1 |
| Switchenko, J | 1 |
| Harvey, RD | 2 |
| Cheung, KWA | 1 |
| Chan, PC | 1 |
| Lo, SH | 1 |
| Winegarden, JA | 1 |
| Carr, DB | 1 |
| Bradshaw, YS | 1 |
| Prakash, S | 1 |
| Meena, JP | 1 |
| Gupta, AK | 1 |
| Bakhshi, S | 1 |
| Velpandian, T | 1 |
| Pandey, RM | 1 |
| Seth, R | 1 |
| Davis, MP | 1 |
| Chung, M | 1 |
| Benkli, B | 1 |
| Roldan, C | 1 |
| Qing, Y | 1 |
| Wang, J | 1 |
| Huh, B | 1 |
| Farquhar-Smith, P | 1 |
| Zhou, N | 1 |
| Fu, Z | 1 |
| Li, H | 1 |
| Wang, K | 1 |
| Bell, RF | 1 |
| Eccleston, C | 1 |
| Kalso, EA | 1 |
| Matic, M | 1 |
| Jongen, JL | 1 |
| Elens, L | 1 |
| de Wildt, SN | 1 |
| Tibboel, D | 1 |
| Sillevis Smitt, PA | 1 |
| van Schaik, RH | 1 |
| Humble, SR | 1 |
| Varela, N | 1 |
| Jayaweera, A | 1 |
| Bhaskar, A | 1 |
| Fallon, MT | 1 |
| Wilcock, A | 1 |
| Kelly, CA | 1 |
| Paul, J | 1 |
| Lewsley, LA | 1 |
| Norrie, J | 1 |
| Laird, BJA | 1 |
| Hakim, RC | 1 |
| Edmonds, KP | 1 |
| Atayee, RS | 2 |
| Mercadante, S | 1 |
| Caruselli, A | 1 |
| Casuccio, A | 1 |
| McCaffrey, N | 1 |
| Flint, T | 1 |
| Kaambwa, B | 1 |
| Fazekas, B | 1 |
| Rowett, D | 1 |
| Currow, DC | 1 |
| Hardy, J | 1 |
| Agar, MR | 1 |
| Quinn, S | 1 |
| Eckermann, S | 1 |
| Zhu, M | 1 |
| Whittaker, AK | 1 |
| Smith, MT | 1 |
| Han, FY | 1 |
| Willeford, A | 1 |
| Winters, KD | 1 |
| Mesarwi, P | 1 |
| Courade, M | 1 |
| Bertrand, A | 1 |
| Guerrini-Rousseau, L | 1 |
| Pagnier, A | 1 |
| Levy, D | 1 |
| Lervat, C | 1 |
| Cojean, N | 1 |
| Ribrault, A | 1 |
| Dugue, S | 1 |
| Thouvenin, S | 1 |
| Piguet, C | 1 |
| Schmitt, C | 1 |
| Marec-Berard, P | 1 |
| Waldfogel, JM | 1 |
| Nesbit, S | 1 |
| Cohen, SP | 1 |
| Dy, SM | 1 |
| Bennett, M | 1 |
| Jonkman, K | 1 |
| van de Donk, T | 1 |
| Dahan, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase II Study About Efficacy and Safety of the Continuous IntraVenous Infusion of Ketamine in Terminally Ill Cancer Patients With Refractory Cancer Pain[NCT03362073] | Phase 2 | 26 participants (Anticipated) | Interventional | 2018-06-01 | Recruiting | ||
| A Pilot Study of the Use of Oral Ketamine for Treatment of Vaso-Occlusive Pain in Adolescents and Young Adults[NCT05378555] | Phase 3 | 10 participants (Anticipated) | Interventional | 2023-05-01 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for ketamine and Cancer Pain
| Article | Year |
|---|---|
Topical Ketamine with Other Adjuvants: Underutilized for Refractory Cancer Pain? A Case Series and Suggested Revision of the World Health Organization Stepladder for Cancer Pain.
Topics: Analgesics; Analgesics, Opioid; Cancer Pain; Humans; Ketamine; Neoplasms; Pain, Intractable; Retrosp | 2020 |
Ketamine as an adjuvant to opioids for cancer pain.
Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Cancer Pain; Chemotherapy, Adjuvant; Female; Hallucinat | 2017 |
Intranasal Ketamine and Its Potential Role in Cancer-Related Pain.
Topics: Administration, Intranasal; Analgesics; Animals; Cancer Pain; Humans; Ketamine; Receptors, N-Methyl- | 2018 |
Chronic postsurgical pain and cancer: the catch of surviving the unsurvivable.
Topics: Analgesics; Analgesics, Opioid; Cancer Pain; Chronic Pain; Drug Therapy, Combination; Gabapentin; Ge | 2018 |
Ketamine for cancer pain: what is the evidence?
Topics: Analgesics; Analgesics, Opioid; Cancer Pain; Drug Therapy, Combination; Humans; Ketamine; Neuralgia; | 2017 |
3 trials available for ketamine and Cancer Pain
| Article | Year |
|---|---|
Ketamine mouthwash versus placebo in the treatment of severe oral mucositis pain in children with cancer: A randomized double-blind placebo-controlled trial.
Topics: Adolescent; Analgesics; Antineoplastic Combined Chemotherapy Protocols; Cancer Pain; Child; Double-B | 2020 |
Ketamine, as adjuvant analgesics for patients with refractory cancer pain, does affect IL-2/IFN-γ expression of T cells in vitro?: A prospective, randomized, double-blind study.
Topics: Analgesics; Cancer Pain; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Interferon-g | 2017 |
Oral Ketamine vs Placebo in Patients With Cancer-Related Neuropathic Pain: A Randomized Clinical Trial.
Topics: Aged; Analgesics; Antineoplastic Agents; Anxiety; Cancer Pain; Cognition Disorders; Depression; Doub | 2018 |
16 other studies available for ketamine and Cancer Pain
| Article | Year |
|---|---|
Role of Ketamine and Opioid Rotation in the Management of Opioid Induced Hyperalgesia in a Patient With Acute Promyelocytic Leukemia.
Topics: Adult; Analgesics, Opioid; Cancer Pain; Female; Humans; Hyperalgesia; Ketamine; Leukemia, Promyelocy | 2022 |
A Case Report of Subanesthetic Ketamine Bolus and Infusion for Opioid Refractory Cancer Pain.
Topics: Analgesics; Analgesics, Opioid; Cancer Pain; Humans; Ketamine; Neoplasms; Pain, Intractable | 2022 |
A dose-escalation clinical trial of intranasal ketamine for uncontrolled cancer-related pain.
Topics: Adult; Analgesics; Analgesics, Opioid; Cancer Pain; Double-Blind Method; Humans; Ketamine; Neoplasms | 2022 |
The use of ketamine in the management of refractory cancer pain in a palliative care unit.
Topics: Analgesics; Analgesics, Opioid; Cancer Pain; Humans; Ketamine; Neoplasms; Palliative Care; Retrospec | 2020 |
Topical Ketamine and Revision of the World Health Organization Step Ladder for Cancer Pain.
Topics: Analgesics; Cancer Pain; Humans; Ketamine; Neoplasms; Pain; World Health Organization | 2020 |
Subanesthetic ketamine in the ambulatory setting for refractory cancer pain: a 6-year retrospective at a cancer center.
Topics: Analgesics; Cancer Pain; Humans; Ketamine; Neoplasms; Pain, Intractable; Quality of Life; Retrospect | 2021 |
Editorial.
Topics: Administration, Topical; Cancer Pain; Humans; Ketamine; Palliative Care | 2017 |
Advanced cancer pain: the search for genetic factors correlated with interindividual variability in opioid requirement.
Topics: Aged; Alleles; Analgesics, Opioid; Cancer Pain; Female; Genotype; Humans; Individuality; Ketamine; M | 2017 |
Case Report: Utility of Ketamine, Lidocaine, and Mexiletine as Nonopioid Adjuvants in Complex Cancer-Associated Pain.
Topics: Adult; Analgesics; Analgesics, Opioid; Anesthetics, Local; Cancer Pain; Carcinoma, Squamous Cell; Fe | 2018 |
The use of ketamine in a palliative-supportive care unit: a retrospective analysis.
Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Cancer Pain; Chemotherapy, Adjuvant; Female; Hum | 2018 |
Economic evaluation of the randomised, double-blind, placebo-controlled study of subcutaneous ketamine in the management of chronic cancer pain.
Topics: Administration, Cutaneous; Adult; Aged; Australia; Cancer Pain; Chronic Pain; Double-Blind Method; F | 2019 |
Bioerodable Ketamine-Loaded Microparticles Fabricated Using Dissolvable Hydrogel Template Technology.
Topics: Absorbable Implants; Analgesics; Cancer Pain; Delayed-Action Preparations; Drug Carriers; Drug Compo | 2019 |
The Enigma of Low-Dose Ketamine for Treatment of Opioid-Induced Hyperalgesia in the Setting of Psychosocial Suffering and Cancer-Associated Pain.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics, Opioid; Cancer Pain; Dose-Response Relationship, D | 2018 |
Low-dose ketamine adjuvant treatment for refractory pain in children, adolescents and young adults with cancer: a pilot study.
Topics: Adolescent; Analgesics; Analgesics, Opioid; Cancer Pain; Child; Child, Preschool; Humans; Ketamine; | 2022 |
Successful Treatment of Opioid-Refractory Cancer Pain with Short-Course, Low-Dose Ketamine.
Topics: Adult; Analgesics; Analgesics, Opioid; Cancer Pain; Dose-Response Relationship, Drug; Humans; Ketami | 2016 |
Pain management for chemotherapy-induced oral mucositis.
Topics: Administration, Intravenous; Analgesics; Analgesics, Opioid; Antineoplastic Agents; Cancer Pain; Chi | 2016 |