ketamine has been researched along with Scoliosis in 23 studies
Ketamine: A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.
ketamine : A member of the class of cyclohexanones in which one of the hydrogens at position 2 is substituted by a 2-chlorophenyl group, while the other is substituted by a methylamino group.
Scoliosis: An appreciable lateral deviation in the normally straight vertical line of the spine. (Dorland, 27th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The mini-dose esketamine-dexmedetomidine combination safely improved analgesia and subjective sleep quality after scoliosis correction surgery." | 9.69 | Mini-dose esketamine-dexmedetomidine combination to supplement analgesia for patients after scoliosis correction surgery: a double-blind randomised trial. ( Cui, F; Ma, JH; Wang, DX; Zhang, Y, 2023) |
| "A total of 48 pediatric patients between 10 and 18 years diagnosed with idiopathic scoliosis were randomized to receive perioperative low-dose ketamine or placebo for 72 hours." | 9.24 | Prolonged Perioperative Low-Dose Ketamine Does Not Improve Short and Long-term Outcomes After Pediatric Idiopathic Scoliosis Surgery. ( Artés, D; Esteban, E; Ey Batlle, AM; Pascuets, C; Perelló, M, 2017) |
| " Here, we utilize fragility indices to assess the statistical robustness of RCTs evaluating low-dose ketamine during scoliosis surgery to reduce opioid tolerance and postoperative pain." | 9.22 | Statistical Fragility of Ketamine Infusion During Scoliosis Surgery to Reduce Opioid Tolerance and Postoperative Pain. ( Al Farii, H; Gupta, A; Mo, K; Movsik, J, 2022) |
| "In this meta-analysis, we aim to compare ketamine use versus a control group (saline solution) during induction of anesthesia in adolescent idiopathic scoliosis patients undergoing fusion surgery in terms of postoperative opioid consumption, pain control, and side effects." | 9.22 | Meta-analysis of the efficacy of ketamine in postoperative pain control in adolescent idiopathic scoliosis patients undergoing spinal fusion. ( Bas, JL; Bas, P; Bas, T; Bovea-Marco, M; Mariscal, G; Morales, J; Pérez, S; Rubio-Belmar, PA, 2022) |
| "In this randomized controlled trial, we examined whether intra- and postoperative infusion of low-dose ketamine decreased postoperative morphine requirement and morphine-related adverse effects as nausea and vomiting after scoliosis surgery." | 9.20 | Intra- and postoperative low-dose ketamine for adolescent idiopathic scoliosis surgery: a randomized controlled trial. ( Hashiguchi, S; Ihara, N; Katori, N; Kosugi, S; Minoshima, R; Morisaki, H; Nishimura, D; Seki, H; Watanabe, K; Yamada, T, 2015) |
| "Ketamine and magnesium association reduces the post-operative morphine consumption after scoliosis surgery." | 9.19 | Ketamine and magnesium association reduces morphine consumption after scoliosis surgery: prospective randomised double-blind study. ( Abou Zeid, HA; Ghanem, IB; Jabbour, HJ; Jabbour, KB; Jawish, RJ; Naccache, NM; Rabbaa-Khabbaz, LG; Yazbeck, PH, 2014) |
| " A number of clinical trials provide evidence that the perioperative use of subanesthetic doses of ketamine reduces pain and opioid requirements in some surgical procedures, but the effect of prolonged perioperative low-dose ketamine infusion in patients undergoing posterior spinal fusion for pediatric scoliosis surgery is unknown." | 9.19 | Prolonged perioperative infusion of low-dose ketamine does not alter opioid use after pediatric scoliosis surgery. ( Cheng, Y; Finkel, JC; Junqueira, MM; Lovejoy, JF; Pestieau, SR; Quezado, Z; Wang, J, 2014) |
| "This study was designed to assess the effect of combination of ketamine and remifentanil infusions as total intravenous anesthesia (TIVA) during scoliosis surgery in children." | 9.13 | The combined effect of ketamine and remifentanil infusions as total intravenous anesthesia for scoliosis surgery in children. ( Moustafa, AM; Negmi, HH; Rabie, ME, 2008) |
| "Thirty-four adolescents aged 12-18 yr scheduled for scoliosis surgery were randomly assigned to receive intraoperative low-dose ketamine (bolus dose of 0." | 9.13 | Intraoperative low-dose ketamine does not prevent a remifentanil-induced increase in morphine requirement after pediatric scoliosis surgery. ( Crawford, MW; de Ruiter, J; Engelhardt, T; Howard, A; Naser, B; Pehora, C; Zaarour, C, 2008) |
| "Dexmedetomidine and ketamine infusions were the main anesthetic for a 15-year-old girl, who underwent scoliosis repair surgery with intraoperative wake-up test, somatosensory evoked potential (SSEP), and motor-evoked potential (MEP) monitoring." | 7.76 | Use of dexmedetomidine and ketamine infusions during scoliosis repair surgery with somatosensory and motor-evoked potential monitoring: a case report. ( Penney, R, 2010) |
| "Ketamine has shown promise to have both opioid sparing and analgesic effects in the postoperative setting." | 6.94 | The efficacy of ketamine for postoperative pain control in adolescent patients undergoing spinal fusion surgery for idiopathic scoliosis. ( Afroze, F; Carl, A; Ehlers, M; Feustel, P; Leduc, L; Metcalfe, B; Pomerantz, M; Ricciardelli, RM; Silverman, E; Walters, NM, 2020) |
| "The mini-dose esketamine-dexmedetomidine combination safely improved analgesia and subjective sleep quality after scoliosis correction surgery." | 5.69 | Mini-dose esketamine-dexmedetomidine combination to supplement analgesia for patients after scoliosis correction surgery: a double-blind randomised trial. ( Cui, F; Ma, JH; Wang, DX; Zhang, Y, 2023) |
| "Twenty female patients (aged 12 to 18 y) with adolescent idiopathic scoliosis scheduled to undergo posterior spinal fusion were randomly allocated to receive ketamine or saline." | 5.41 | A Bolus Dose of Ketamine Reduces the Amplitude of the Transcranial Electrical Motor-evoked Potential: A Randomized, Double-blinded, Placebo-controlled Study. ( Baba, H; Deguchi, H; Furutani, K; Kamiya, Y; Matsuhashi, M; Mitsuma, Y, 2021) |
| "A total of 48 pediatric patients between 10 and 18 years diagnosed with idiopathic scoliosis were randomized to receive perioperative low-dose ketamine or placebo for 72 hours." | 5.24 | Prolonged Perioperative Low-Dose Ketamine Does Not Improve Short and Long-term Outcomes After Pediatric Idiopathic Scoliosis Surgery. ( Artés, D; Esteban, E; Ey Batlle, AM; Pascuets, C; Perelló, M, 2017) |
| " Here, we utilize fragility indices to assess the statistical robustness of RCTs evaluating low-dose ketamine during scoliosis surgery to reduce opioid tolerance and postoperative pain." | 5.22 | Statistical Fragility of Ketamine Infusion During Scoliosis Surgery to Reduce Opioid Tolerance and Postoperative Pain. ( Al Farii, H; Gupta, A; Mo, K; Movsik, J, 2022) |
| "In this meta-analysis, we aim to compare ketamine use versus a control group (saline solution) during induction of anesthesia in adolescent idiopathic scoliosis patients undergoing fusion surgery in terms of postoperative opioid consumption, pain control, and side effects." | 5.22 | Meta-analysis of the efficacy of ketamine in postoperative pain control in adolescent idiopathic scoliosis patients undergoing spinal fusion. ( Bas, JL; Bas, P; Bas, T; Bovea-Marco, M; Mariscal, G; Morales, J; Pérez, S; Rubio-Belmar, PA, 2022) |
| "In this randomized controlled trial, we examined whether intra- and postoperative infusion of low-dose ketamine decreased postoperative morphine requirement and morphine-related adverse effects as nausea and vomiting after scoliosis surgery." | 5.20 | Intra- and postoperative low-dose ketamine for adolescent idiopathic scoliosis surgery: a randomized controlled trial. ( Hashiguchi, S; Ihara, N; Katori, N; Kosugi, S; Minoshima, R; Morisaki, H; Nishimura, D; Seki, H; Watanabe, K; Yamada, T, 2015) |
| "Ketamine and magnesium association reduces the post-operative morphine consumption after scoliosis surgery." | 5.19 | Ketamine and magnesium association reduces morphine consumption after scoliosis surgery: prospective randomised double-blind study. ( Abou Zeid, HA; Ghanem, IB; Jabbour, HJ; Jabbour, KB; Jawish, RJ; Naccache, NM; Rabbaa-Khabbaz, LG; Yazbeck, PH, 2014) |
| " A number of clinical trials provide evidence that the perioperative use of subanesthetic doses of ketamine reduces pain and opioid requirements in some surgical procedures, but the effect of prolonged perioperative low-dose ketamine infusion in patients undergoing posterior spinal fusion for pediatric scoliosis surgery is unknown." | 5.19 | Prolonged perioperative infusion of low-dose ketamine does not alter opioid use after pediatric scoliosis surgery. ( Cheng, Y; Finkel, JC; Junqueira, MM; Lovejoy, JF; Pestieau, SR; Quezado, Z; Wang, J, 2014) |
| "This study was designed to assess the effect of combination of ketamine and remifentanil infusions as total intravenous anesthesia (TIVA) during scoliosis surgery in children." | 5.13 | The combined effect of ketamine and remifentanil infusions as total intravenous anesthesia for scoliosis surgery in children. ( Moustafa, AM; Negmi, HH; Rabie, ME, 2008) |
| "Thirty-four adolescents aged 12-18 yr scheduled for scoliosis surgery were randomly assigned to receive intraoperative low-dose ketamine (bolus dose of 0." | 5.13 | Intraoperative low-dose ketamine does not prevent a remifentanil-induced increase in morphine requirement after pediatric scoliosis surgery. ( Crawford, MW; de Ruiter, J; Engelhardt, T; Howard, A; Naser, B; Pehora, C; Zaarour, C, 2008) |
| ": To determine the effect of low-dose ketamine on the voltage needed to elicit maximal amplitude of the motor-evoked response to transcranial electrical stimulation during propofol/remifentanil anesthesia in children undergoing scoliosis surgery." | 5.12 | Effect of low-dose ketamine on voltage requirement for transcranial electrical motor evoked potentials in children. ( Crawford, MW; Engelhardt, T; Lewis, S; Pehora, C; Strantzas, S; Zaarour, C, 2007) |
| "Dexmedetomidine and ketamine infusions were the main anesthetic for a 15-year-old girl, who underwent scoliosis repair surgery with intraoperative wake-up test, somatosensory evoked potential (SSEP), and motor-evoked potential (MEP) monitoring." | 3.76 | Use of dexmedetomidine and ketamine infusions during scoliosis repair surgery with somatosensory and motor-evoked potential monitoring: a case report. ( Penney, R, 2010) |
| "Ketamine has shown promise to have both opioid sparing and analgesic effects in the postoperative setting." | 2.94 | The efficacy of ketamine for postoperative pain control in adolescent patients undergoing spinal fusion surgery for idiopathic scoliosis. ( Afroze, F; Carl, A; Ehlers, M; Feustel, P; Leduc, L; Metcalfe, B; Pomerantz, M; Ricciardelli, RM; Silverman, E; Walters, NM, 2020) |
| "Ketamine 1." | 1.48 | Marked attenuation of the amplitude of transcranial motor-evoked potentials after intravenous bolus administration of ketamine: a case report. ( Baba, H; Deguchi, H; Furutani, K; Matsuhashi, M; Mitsuma, Y; Ohashi, N, 2018) |
| "Idiopathic scoliosis is a condition that may require surgical correction." | 1.46 | Anesthetic considerations for a novel anterior surgical approach to pediatric scoliosis correction. ( Antonacci, MD; Betz, RR; Cuddihy, LA; Curatolo, CJ; DeMaria, S; Gal, JS; Hill, B; Khelemsky, Y; Lonner, B; Zerillo, J, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.35) | 18.7374 |
| 1990's | 1 (4.35) | 18.2507 |
| 2000's | 8 (34.78) | 29.6817 |
| 2010's | 8 (34.78) | 24.3611 |
| 2020's | 5 (21.74) | 2.80 |
| Authors | Studies |
|---|---|
| Gupta, A | 1 |
| Mo, K | 1 |
| Movsik, J | 1 |
| Al Farii, H | 1 |
| Mariscal, G | 1 |
| Morales, J | 1 |
| Pérez, S | 1 |
| Rubio-Belmar, PA | 1 |
| Bovea-Marco, M | 1 |
| Bas, JL | 1 |
| Bas, P | 1 |
| Bas, T | 1 |
| Zhang, Y | 1 |
| Cui, F | 1 |
| Ma, JH | 1 |
| Wang, DX | 1 |
| Furutani, K | 2 |
| Deguchi, H | 2 |
| Matsuhashi, M | 2 |
| Mitsuma, Y | 2 |
| Kamiya, Y | 1 |
| Baba, H | 3 |
| Ricciardelli, RM | 1 |
| Walters, NM | 1 |
| Pomerantz, M | 1 |
| Metcalfe, B | 1 |
| Afroze, F | 1 |
| Ehlers, M | 1 |
| Leduc, L | 1 |
| Feustel, P | 1 |
| Silverman, E | 1 |
| Carl, A | 1 |
| Gal, JS | 1 |
| Curatolo, CJ | 1 |
| Zerillo, J | 1 |
| Hill, B | 1 |
| Lonner, B | 1 |
| Cuddihy, LA | 1 |
| Antonacci, MD | 1 |
| Betz, RR | 1 |
| DeMaria, S | 1 |
| Khelemsky, Y | 1 |
| Ohashi, N | 1 |
| Jabbour, HJ | 1 |
| Naccache, NM | 1 |
| Jawish, RJ | 1 |
| Abou Zeid, HA | 1 |
| Jabbour, KB | 1 |
| Rabbaa-Khabbaz, LG | 1 |
| Ghanem, IB | 1 |
| Yazbeck, PH | 1 |
| Pestieau, SR | 1 |
| Finkel, JC | 1 |
| Junqueira, MM | 1 |
| Cheng, Y | 1 |
| Lovejoy, JF | 1 |
| Wang, J | 1 |
| Quezado, Z | 1 |
| Minoshima, R | 1 |
| Kosugi, S | 1 |
| Nishimura, D | 1 |
| Ihara, N | 1 |
| Seki, H | 1 |
| Yamada, T | 1 |
| Watanabe, K | 1 |
| Katori, N | 1 |
| Hashiguchi, S | 1 |
| Morisaki, H | 1 |
| Perelló, M | 1 |
| Artés, D | 1 |
| Pascuets, C | 1 |
| Esteban, E | 1 |
| Ey Batlle, AM | 1 |
| Moustafa, AM | 1 |
| Negmi, HH | 1 |
| Rabie, ME | 1 |
| Engelhardt, T | 2 |
| Zaarour, C | 2 |
| Naser, B | 1 |
| Pehora, C | 2 |
| de Ruiter, J | 1 |
| Howard, A | 1 |
| Crawford, MW | 2 |
| Devarakonda, KM | 1 |
| Lowthian, D | 1 |
| Raghavendra, T | 1 |
| Penney, R | 1 |
| Brennen, K | 1 |
| König, M | 1 |
| Mahmoud, M | 1 |
| Ul'rikh, GE | 1 |
| Gordeev, VI | 1 |
| Mokhammed Khusseĭn, IaIa | 1 |
| Kachalova, EG | 1 |
| Tsui, BC | 1 |
| Wagner, A | 1 |
| Mahood, J | 1 |
| Moreau, M | 1 |
| Aguirre, J | 1 |
| Blumenthal, S | 1 |
| Borgeat, A | 1 |
| Strantzas, S | 1 |
| Lewis, S | 1 |
| Onaka, M | 1 |
| Yamamoto, H | 1 |
| Akatsuka, M | 1 |
| Mori, H | 1 |
| Shimizu, M | 1 |
| Yamakura, T | 1 |
| Tobita, T | 1 |
| Okamoto, M | 1 |
| Ataka, T | 1 |
| Fujihara, H | 1 |
| Taga, K | 1 |
| Shimoji, K | 1 |
| Shin, FT | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Comparison of Analgesia Methods Used for Spinal Surgery[NCT04603638] | 82 participants (Anticipated) | Interventional | 2020-03-04 | Recruiting | |||
| The Effect of a Regimen of Opioid Sparing Anesthesia on Postoperative Recovery[NCT05594407] | 60 participants (Anticipated) | Interventional | 2022-08-01 | Recruiting | |||
| Modulation of μ Opioid Receptor Mediated Analgesia, Tolerance and Hyperalgesia in Children and Adolescents[NCT01325493] | Phase 4 | 54 participants (Actual) | Interventional | 2010-01-31 | Completed | ||
| Evaluation of the Effect of Ketamine on Remifentanil-induced Hyperalgesia Using Filaments, an Algometer, and Interleukins: a Double-blind, Randomized Study[NCT01301079] | Phase 3 | 60 participants (Actual) | Interventional | 2010-09-30 | Completed | ||
| Effect of Ultra-low Dose Naloxone on Remifentanil-Induced Hyperalgesia[NCT03066739] | Phase 2 | 105 participants (Anticipated) | Interventional | 2023-02-25 | Recruiting | ||
| Influence of Dexmedetomidine and Lidocaine on Opioid Consumption, Cognitive Function and Incidence of Neuropathic Pain in Laparoscopic Intestine Resection[NCT02616523] | Phase 4 | 60 participants (Actual) | Interventional | 2014-07-31 | Completed | ||
| A Prospective, Randomized, Double-Blind, Controlled Trial Evaluating the Efficacy of Ketamine for Improvement in Postoperative Pain Control After Spinal Fusion for Idiopathic Scoliosis[NCT02651324] | Phase 4 | 50 participants (Anticipated) | Interventional | 2013-05-31 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Morphine consumption (mg/kg) was measured over time in the Ketamine group and compared to the Control (saline) group. Values are for each 24 hour time period and displayed as hours post surgery. (NCT01325493)
Timeframe: at 24, 48, 72, 96 hours post operatively
| Intervention | mg/kg (Mean) | |||
|---|---|---|---|---|
| 24 hrs after surgery | 48 hrs after surgery | 72 hrs after surgery | 96 hrs after surgery | |
| Ketamine | 1.3 | 1.28 | .89 | .57 |
| Saline | 1.36 | 1.275 | .93 | .38 |
Patient volunteered response at rest, 1-10 scale (where a higher score indicates more pain and a lower score indicates less pain). Values are for each 24 hour time period and displayed as hours post surgery. (NCT01325493)
Timeframe: 24, 48, 72, 96 hours post operatively
| Intervention | pain score at rest (Mean) | |||
|---|---|---|---|---|
| 24 hrs after surgery | 48 hrs after surgery | 72 hrs after surgery | 96 hrs after surgery | |
| Ketamine | 3.9 | 4.53 | 3.6 | 4.48 |
| Saline | 4.55 | 5.2 | 3.48 | 3.8 |
Patient volunteered response during a cough, 1-10 scale (where a higher score indicates more pain and a lower score indicates less pain). Values are for each 24 hour time period and displayed as hours post surgery. (NCT01325493)
Timeframe: 24, 48, 72, 96 hours post operatively
| Intervention | pain score at cough (Mean) | |||
|---|---|---|---|---|
| 24 hrs after surgery | 48 hrs after surgery | 72 hrs after surgery | 96 hrs after surgery | |
| Ketamine | 4.5 | 5.4 | 4.4 | 5.15 |
| Saline | 5.1 | 5.45 | 3.7 | 4.2 |
"Sedation scores 0 = completely awake~= sleepy but responds appropriately~= somnolent but arouses to light stimuli~= asleep but responsive to deeper physical stimuli~= asleep and not responsive to any stimuli Values are for each 24 hour time period and displayed as hours post surgery." (NCT01325493)
Timeframe: 24, 48, 72, 96 hours post operatively
| Intervention | Sedation Score (Mean) | |||
|---|---|---|---|---|
| 24 hrs after surgery | 48 hrs after surgery | 72 hrs after surgery | 96 hrs after surgery | |
| Ketamine | .73 | .62 | .38 | .24 |
| Saline | .75 | .54 | .3 | .21 |
The evaluations using the soft brush were performed 2-3 cm from the incision in the periumbilical region (where the large trocar was placed) 24 h after the procedure (NCT01301079)
Timeframe: 24 h after the procedure
| Intervention | participants (Number) |
|---|---|
| Ketamine | 1 |
| Saline | 0 |
The evaluations using the soft brush were performed 2-3 cm from the incision in the periumbilical region (where the large trocar was placed) before the procedure (NCT01301079)
Timeframe: Before the procedure (Baseline)
| Intervention | participants (Number) |
|---|---|
| Ketamine | 1 |
| Saline | 0 |
The evaluations using the soft brush were performed in the thenar eminence of the non dominant hand 24 h after the procedure (NCT01301079)
Timeframe: 24 h after the procedure
| Intervention | participants (Number) |
|---|---|
| Ketamine | 1 |
| Saline | 3 |
The evaluations using the soft brush were performed in the thenar eminence of the nondominant hand before the procedure (NCT01301079)
Timeframe: Before the procedure (Baseline)
| Intervention | participants (Number) |
|---|---|
| Ketamine | 1 |
| Saline | 0 |
The 300-g filament was used 24 hours after the operation to induce a stimulus and delineate the extent of hyperalgesia from the periumbilical region. The stimulus was started outside the periumbilical region, where no pain sensation was reported, and continued every 0.5 cm until the 4 points of the periumbilical scar were reached (top, right side, left side, and bottom). The first point where the patient complained of pain was marked. If no pain sensation was reported, the stimulus was terminated 0.5 cm from the incision. The distance of each point from the surgical incision was measured, and the sum of the distances of the points was determined. (NCT01301079)
Timeframe: 24 hours after the procedure
| Intervention | centimeter (Mean) |
|---|---|
| Ketamine | 10.61 |
| Saline | 11.82 |
The mechanical pain threshold was evaluated using an algometer. The pressure was increased by 0.1 kgf/second until the patient complained of pain. The mean of three determinations was calculated. (NCT01301079)
Timeframe: 24 h after the procedure
| Intervention | kilogram force/second (Mean) |
|---|---|
| Ketamine | 3.5 |
| Saline | 3.7 |
The mechanical pain threshold was evaluated using an algometer. The pressure was increased by 0.1 kgf/second until the patient complained of pain. The mean of three determinations was calculated. (NCT01301079)
Timeframe: 24 h after the procedure
| Intervention | kilogram force/second (Mean) |
|---|---|
| Ketamine | 0.56 |
| Saline | 0.51 |
The pain threshold was assessed using six von Frey monofilaments (0,05 g; 0,2 g; 2 g; 4 g; 10 g e 300 g) in the periumbilical region in the postoperative period (24h after the procedure). The use of different von Frey monofilaments, starting with the lightest and ending with the heaviest, was separated by at least 30 seconds to reduce any anticipated responses due to a new stimulation that was performed too soon after the preceding stimulation. Three assessments were made for each monofilament, and this was considered positive when the patient responded to two of the determinations for each monofilament. (NCT01301079)
Timeframe: 24h after the procedure
| Intervention | gram (Mean) |
|---|---|
| Ketamine | 248 |
| Saline | 205 |
The pain threshold was assessed using six von Frey monofilaments (0,05 g; 0,2 g; 2 g; 4 g; 10 g e 300 g) in thenar eminence in the postoperative period (24 hours after procedure). The use of different von Frey monofilaments, starting with the lightest and ending with the heaviest, was separated by at least 30 seconds to reduce any anticipated responses due to a new stimulation that was performed too soon after the preceding stimulation. Three assessments were made for each monofilament, and this was considered positive when the patient responded to two of the determinations for each monofilament. (NCT01301079)
Timeframe: 24 hours after procedure
| Intervention | gram (Mean) |
|---|---|
| Ketamine | 290 |
| Saline | 247 |
The mechanical pain threshold was evaluated using an algometer. The pressure was increased by 0.1 kgf/second until the patient complained of pain. The mean of three determinations was calculated. (NCT01301079)
Timeframe: Baseline (before the surgery)
| Intervention | kilogram force/second (Mean) |
|---|---|
| Ketamine | 3.6 |
| Saline | 3.9 |
The mechanical pain threshold was evaluated using an algometer. The pressure was increased by 0.1 kgf/second until the patient complained of pain. The mean of three determinations was calculated. (NCT01301079)
Timeframe: Baseline (before the procedure)
| Intervention | kilogram force/second (Mean) |
|---|---|
| Ketamine | 2.51 |
| Saline | 2.19 |
The pain threshold was assessed using six von Frey monofilaments (0,05 g; 0,2 g; 2 g; 4 g; 10 g e 300 g) in the periumbilical region in the preoperative period. The use of different von Frey monofilaments, starting with the lightest and ending with the heaviest, was separated by at least 30 seconds to reduce any anticipated responses due to a new stimulation that was performed too soon after the preceding stimulation. Three assessments were made for each monofilament, and this was considered positive when the patient responded to two of the determinations for each monofilament. (NCT01301079)
Timeframe: Before the procedure (Baseline)
| Intervention | gram (Mean) |
|---|---|
| Ketamine | 279 |
| Saline | 269 |
The pain threshold was assessed using six von Frey monofilaments (0,05 g; 0,2 g; 2 g; 4 g; 10 g e 300 g) in thenar eminence in the preoperative period. The use of different von Frey monofilaments, starting with the lightest and ending with the heaviest, was separated by at least 30 seconds to reduce any anticipated responses due to a new stimulation that was performed too soon after the preceding stimulation. Three assessments were made for each monofilament, and this was considered positive when the patient responded to two of the determinations for each monofilament. (NCT01301079)
Timeframe: Before the procedure (Baseline)
| Intervention | gram (Mean) |
|---|---|
| Ketamine | 300 |
| Saline | 300 |
(NCT01301079)
Timeframe: 24 hours
| Intervention | milligram (Mean) |
|---|---|
| Ketamine | 27.40 |
| Saline | 27.70 |
The scale measure pain after 12 hours (0 - without pain and 10 worst pain possible). The individual can choose any number between 0 - 10. (NCT01301079)
Timeframe: 12 hours
| Intervention | units on a scale (Mean) |
|---|---|
| Ketamine | 1.6 |
| Saline | 1.4 |
The scale measure pain after 120 minutes (0 - without pain and 10 worst pain possible). The individual can choose any number between 0 - 10. (NCT01301079)
Timeframe: 120 minutes
| Intervention | units on a scale (Mean) |
|---|---|
| Ketamine | 2.2 |
| Saline | 2.0 |
The scale measure pain after 150 minutes (0 - without pain and 10 worst pain possible). The individual can choose any number between 0 - 10. (NCT01301079)
Timeframe: 150 minutes
| Intervention | units on a scale (Mean) |
|---|---|
| Ketamine | 1.4 |
| Saline | 1.4 |
The scale measure pain after 18 hours (0 - without pain and 10 worst pain possible). The individual can choose any number between 0 - 10. (NCT01301079)
Timeframe: 18 hours
| Intervention | units on a scale (Mean) |
|---|---|
| Ketamine | 1.5 |
| Saline | 1.3 |
The scale measure pain after 180 minutes (0 - without pain and 10 worst pain possible). The individual can choose any number between 0 - 10. (NCT01301079)
Timeframe: 180 minutes
| Intervention | units on a scale (Mean) |
|---|---|
| Ketamine | 1.1 |
| Saline | 1.3 |
The scale measure pain after 210 minutes (0 - without pain and 10 worst pain possible). The individual can choose any number between 0 - 10. (NCT01301079)
Timeframe: 210 minutes
| Intervention | units on a scale (Mean) |
|---|---|
| Ketamine | 0.9 |
| Saline | 1.2 |
The scale measure pain after 24 hours (0 - without pain and 10 worst pain possible). The individual can choose any number between 0 - 10. (NCT01301079)
Timeframe: 24 hours
| Intervention | units on a scale (Mean) |
|---|---|
| Ketamine | 1.4 |
| Saline | 0.8 |
The scale measure pain after 240 minutes (0 - without pain and 10 worst pain possible). The individual can choose any number between 0 - 10. (NCT01301079)
Timeframe: 240 minutes
| Intervention | units on a scale (Mean) |
|---|---|
| Ketamine | 1.0 |
| Saline | 1.1 |
The scale measure pain after 30 minutes (0 - without pain and 10 worst pain possible). The individual can choose any number between 0 - 10. (NCT01301079)
Timeframe: 30 minutes
| Intervention | units on a scale (Mean) |
|---|---|
| Ketamine | 5.5 |
| Saline | 6.2 |
The scale measure pain after 6 hours (0 - without pain and 10 worst pain possible). The individual can choose any number between 0 - 10. (NCT01301079)
Timeframe: 6 hours
| Intervention | units on a scale (Mean) |
|---|---|
| Ketamine | 0.9 |
| Saline | 0.7 |
The scale measure pain after 60 minutes (0 - without pain and 10 worst pain possible). The individual can choose any number between 0 - 10. (NCT01301079)
Timeframe: 60 minutes
| Intervention | units on a scale (Mean) |
|---|---|
| Ketamine | 4.6 |
| Saline | 5.1 |
The scale measure pain after 90 minutes (0 - without pain and 10 worst pain possible). The individual can choose any number between 0 - 10. (NCT01301079)
Timeframe: 90 minutes
| Intervention | units on a scale (Mean) |
|---|---|
| Ketamine | 3.4 |
| Saline | 3.4 |
Blood samples were drawn in ethylenediaminetetraacetic acid (EDTA) tubes 24 h after the surgery. The blood was centrifuged to separate the plasma and was stored at -70°C. IL-6 was analyzed using the enzyme-linked immunosorbent assay (ELISA) methodology. (NCT01301079)
Timeframe: 24 h after the procedure
| Intervention | picogram/milliliter (Mean) |
|---|---|
| Ketamine | 8.6 |
| Saline | 5.0 |
Blood samples were drawn in ethylenediaminetetraacetic acid (EDTA) tubes 5 h after the surgery. The blood was centrifuged to separate the plasma and was stored at -70°C. IL-10 was analyzed using the enzyme-linked immunosorbent assay (ELISA) methodology. (NCT01301079)
Timeframe: 5h after the procedure
| Intervention | picogram/milliliter (Mean) |
|---|---|
| Ketamine | 9.1 |
| Saline | 5.5 |
Blood samples were drawn in ethylenediaminetetraacetic acid (EDTA) tubes before the surgery. The blood was centrifuged to separate the plasma and was stored at -70°C. IL-6 was analyzed using the enzyme-linked immunosorbent assay (ELISA) methodology. (NCT01301079)
Timeframe: Baseline (Before the procedure)
| Intervention | picogram/milliliter (Mean) |
|---|---|
| Ketamine | 7.8 |
| Saline | 1.9 |
Blood samples were drawn in ethylenediaminetetraacetic acid (EDTA) tubes 24 h after the surgery. The blood was centrifuged to separate the plasma and was stored at -70°C. IL-6 was analyzed using the enzyme-linked immunosorbent assay (ELISA) methodology. (NCT01301079)
Timeframe: 24 h after the procedure
| Intervention | picogram/milliliter (Mean) |
|---|---|
| Ketamine | 24.1 |
| Saline | 24.8 |
Blood samples were drawn in ethylenediaminetetraacetic acid (EDTA) tubes 5 h after the surgery. The blood was centrifuged to separate the plasma and was stored at -70°C. IL-6 was analyzed using the enzyme-linked immunosorbent assay (ELISA) methodology. (NCT01301079)
Timeframe: 5 h after the procedure
| Intervention | picogram/milliliter (Mean) |
|---|---|
| Ketamine | 29.3 |
| Saline | 34.8 |
Blood samples were drawn in ethylenediaminetetraacetic acid (EDTA) tubes before the surgery. The blood was centrifuged to separate the plasma and was stored at -70°C. IL-6 was analyzed using the enzyme-linked immunosorbent assay (ELISA) methodology. (NCT01301079)
Timeframe: Baseline (Before the procedure)
| Intervention | picogram/milliliter (Mean) |
|---|---|
| Ketamine | 3.3 |
| Saline | 2.1 |
Blood samples were drawn in ethylenediaminetetraacetic acid (EDTA) tubes 24 h after the surgery. The blood was centrifuged to separate the plasma and was stored at -70°C. IL-8 was analyzed using the enzyme-linked immunosorbent assay (ELISA) methodology. (NCT01301079)
Timeframe: 24 h after the procedure
| Intervention | picogram/milliliter (Mean) |
|---|---|
| Ketamine | 6.0 |
| Saline | 4.5 |
Blood samples were drawn in ethylenediaminetetraacetic acid (EDTA) tubes 5 h after the surgery. The blood was centrifuged to separate the plasma and was stored at -70°C. IL-8 was analyzed using the enzyme-linked immunosorbent assay (ELISA) methodology. (NCT01301079)
Timeframe: 5 h after the procedure
| Intervention | picogram/milliliter (Mean) |
|---|---|
| Ketamine | 8.0 |
| Saline | 11.3 |
Blood samples were drawn in ethylenediaminetetraacetic acid (EDTA) tubes before the surgery. The blood was centrifuged to separate the plasma and was stored at -70°C. IL-8 was analyzed using the enzyme-linked immunosorbent assay (ELISA) methodology. (NCT01301079)
Timeframe: Baseline (Before the procedure)
| Intervention | picogram/milliliter (Mean) |
|---|---|
| Ketamine | 3.3 |
| Saline | 2.2 |
(NCT01301079)
Timeframe: 24 hours
| Intervention | minutes (Median) |
|---|---|
| Ketamine | 18 |
| Saline | 15 |
consumption of fentanyl (mg) during the procedure (NCT02616523)
Timeframe: time of the operation
| Intervention | mg (Mean) |
|---|---|
| Dexmedetomidine | 41 |
| Lidocaine | 50 |
| Placebo | 58 |
consumption of piritramide (mg) in the recovery room (NCT02616523)
Timeframe: one hour after the operation
| Intervention | mg (Mean) |
|---|---|
| Dexmedetomidine | 4.63 |
| Lidocaine | 5.25 |
| Placebo | 4.25 |
Pain questionnaire dn4 will be send to participants after two months of surgery to evaluate the neuropathic pain. There are minimum 0 points and maximum 10 points. If the score is 4 or higher then the pain is likely to be neuropathic pain. (NCT02616523)
Timeframe: two months after the surgery
| Intervention | units on a scale (Mean) |
|---|---|
| Dexmedetomidine | 0.11 |
| Lidocaine | 0.00 |
| Placebo | 0.45 |
2 reviews available for ketamine and Scoliosis
| Article | Year |
|---|---|
Statistical Fragility of Ketamine Infusion During Scoliosis Surgery to Reduce Opioid Tolerance and Postoperative Pain.
Topics: Adolescent; Analgesics, Opioid; Humans; Ketamine; Pain, Postoperative; Sample Size; Scoliosis | 2022 |
Meta-analysis of the efficacy of ketamine in postoperative pain control in adolescent idiopathic scoliosis patients undergoing spinal fusion.
Topics: Adolescent; Analgesics, Opioid; Humans; Ketamine; Kyphosis; Morphine; Pain, Postoperative; Saline So | 2022 |
11 trials available for ketamine and Scoliosis
| Article | Year |
|---|---|
Mini-dose esketamine-dexmedetomidine combination to supplement analgesia for patients after scoliosis correction surgery: a double-blind randomised trial.
Topics: Adult; Analgesia; Dexmedetomidine; Double-Blind Method; Female; Humans; Ketamine; Male; Pain, Postop | 2023 |
A Bolus Dose of Ketamine Reduces the Amplitude of the Transcranial Electrical Motor-evoked Potential: A Randomized, Double-blinded, Placebo-controlled Study.
Topics: Adolescent; Evoked Potentials, Motor; Female; Humans; Ketamine; Propofol; Remifentanil; Scoliosis | 2021 |
The efficacy of ketamine for postoperative pain control in adolescent patients undergoing spinal fusion surgery for idiopathic scoliosis.
Topics: Analgesics; Child; Double-Blind Method; Drug Therapy, Combination; Drug Utilization; Female; Humans; | 2020 |
Ketamine and magnesium association reduces morphine consumption after scoliosis surgery: prospective randomised double-blind study.
Topics: Adolescent; Analgesia, Patient-Controlled; Analgesics; Child; Double-Blind Method; Drug Therapy, Com | 2014 |
Ketamine and magnesium association reduces morphine consumption after scoliosis surgery: prospective randomised double-blind study.
Topics: Adolescent; Analgesia, Patient-Controlled; Analgesics; Child; Double-Blind Method; Drug Therapy, Com | 2014 |
Ketamine and magnesium association reduces morphine consumption after scoliosis surgery: prospective randomised double-blind study.
Topics: Adolescent; Analgesia, Patient-Controlled; Analgesics; Child; Double-Blind Method; Drug Therapy, Com | 2014 |
Ketamine and magnesium association reduces morphine consumption after scoliosis surgery: prospective randomised double-blind study.
Topics: Adolescent; Analgesia, Patient-Controlled; Analgesics; Child; Double-Blind Method; Drug Therapy, Com | 2014 |
Prolonged perioperative infusion of low-dose ketamine does not alter opioid use after pediatric scoliosis surgery.
Topics: Adolescent; Analgesics, Opioid; Anesthetics, Dissociative; Child; Double-Blind Method; Drug Toleranc | 2014 |
Intra- and postoperative low-dose ketamine for adolescent idiopathic scoliosis surgery: a randomized controlled trial.
Topics: Adolescent; Child; Female; Humans; Ketamine; Male; Morphine; Pain, Postoperative; Postoperative Naus | 2015 |
Prolonged Perioperative Low-Dose Ketamine Does Not Improve Short and Long-term Outcomes After Pediatric Idiopathic Scoliosis Surgery.
Topics: Analgesia, Patient-Controlled; Child; Double-Blind Method; Female; Humans; Ketamine; Male; Morphine; | 2017 |
The combined effect of ketamine and remifentanil infusions as total intravenous anesthesia for scoliosis surgery in children.
Topics: Adolescent; Anesthesia Recovery Period; Anesthesia, Intravenous; Anesthetics, Intravenous; Child; Co | 2008 |
Intraoperative low-dose ketamine does not prevent a remifentanil-induced increase in morphine requirement after pediatric scoliosis surgery.
Topics: Adolescent; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Anesthetics, Intravenous; | 2008 |
Intraoperative low-dose ketamine does not prevent a remifentanil-induced increase in morphine requirement after pediatric scoliosis surgery.
Topics: Adolescent; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Anesthetics, Intravenous; | 2008 |
Intraoperative low-dose ketamine does not prevent a remifentanil-induced increase in morphine requirement after pediatric scoliosis surgery.
Topics: Adolescent; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Anesthetics, Intravenous; | 2008 |
Intraoperative low-dose ketamine does not prevent a remifentanil-induced increase in morphine requirement after pediatric scoliosis surgery.
Topics: Adolescent; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Anesthetics, Intravenous; | 2008 |
Effect of low-dose ketamine on voltage requirement for transcranial electrical motor evoked potentials in children.
Topics: Adolescent; Anesthetics, Dissociative; Anesthetics, Intravenous; Child; Dose-Response Relationship, | 2007 |
Propofol enhances GABA(A) receptor-mediated presynaptic inhibition in human spinal cord.
Topics: Adolescent; Anesthetics, Dissociative; Anesthetics, Intravenous; Child; Evoked Potentials; Female; G | 2002 |
10 other studies available for ketamine and Scoliosis
| Article | Year |
|---|---|
Anesthetic considerations for a novel anterior surgical approach to pediatric scoliosis correction.
Topics: Adolescent; Anesthesia, General; Anesthetics, Dissociative; Anesthetics, Intravenous; Bone Screws; C | 2017 |
Marked attenuation of the amplitude of transcranial motor-evoked potentials after intravenous bolus administration of ketamine: a case report.
Topics: Administration, Intravenous; Adolescent; Anesthetics, Dissociative; Evoked Potentials, Motor; Female | 2018 |
A case of Rett syndrome with reduced pain sensitivity.
Topics: Adolescent; Analgesia; Analgesics; Anesthetics, Combined; Female; Humans; Ketamine; Morphine; Pain M | 2009 |
Use of dexmedetomidine and ketamine infusions during scoliosis repair surgery with somatosensory and motor-evoked potential monitoring: a case report.
Topics: Adjuvants, Anesthesia; Adolescent; Anesthesia, Intravenous; Anesthetics, Dissociative; Dexmedetomidi | 2010 |
Use of dexmedetomidine and ketamine infusions during scoliosis repair surgery with somatosensory and motor-evoked potential monitoring: a case report.
Topics: Anesthetics, Dissociative; Dexmedetomidine; Evoked Potentials, Motor; Evoked Potentials, Somatosenso | 2011 |
[Effects of induction of anesthesia on hemodynamics in children with deformities of the spinal cord when turning to the position lying on the belly].
Topics: Adolescent; Age Factors; Analgesics; Anesthetics, Combined; Anesthetics, Dissociative; Anesthetics, | 2005 |
Adjunct continuous intravenous ketamine infusion for postoperative pain relief following posterior spinal instrumentation for correction of scoliosis: a case report.
Topics: Adolescent; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Drug Therapy, Combination | 2007 |
Ketamine and spinal instrumentation.
Topics: Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Humans; Ketamine; Pain, Postoperative | 2007 |
[Continuous total intravenous anesthesia is recommended for wake-up test].
Topics: Anesthesia Recovery Period; Anesthesia, Intravenous; Anesthetics, Combined; Buprenorphine; Child; Fe | 1999 |
Some anaesthetic problems in corrective spinal surgery in children in Hong Kong.
Topics: Anesthesia; Anesthesia, General; Blood Transfusion; Child; Hemorrhage; Hong Kong; Humans; Intubation | 1973 |