ketamine has been researched along with Brain Ischemia in 65 studies
Ketamine: A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.
ketamine : A member of the class of cyclohexanones in which one of the hydrogens at position 2 is substituted by a 2-chlorophenyl group, while the other is substituted by a methylamino group.
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate the effects of ketamine pretreatment on cerebral edema following brain ischemia reperfusion injury in rats and assess the involvement of Aquaporin 4 (AQP4) expression." | 7.76 | [The effects of ketamine pretreated on cerebral edema and AQP4 expression after transient focal cerebral ischemia/reperfusion in rats]. ( Cai, SN; Zhu, SM, 2010) |
| "To determine if the inhibitory effects of ketamine on the extracellular signal-regulated kinase (ERK) 1/2 are involved in reduction of the hyperglycemia-exaggerated cerebral ischemic lesion, rats with normoglycemia, hyperglycemia, or hyperglycemia supplemented with ketamine were subjected to 15 min of forebrain ischemia, and then, reperfusion for 0." | 7.74 | Inhibitory effect of ketamine on phosphorylation of the extracellular signal-regulated kinase 1/2 following brain ischemia and reperfusion in rats with hyperglycemia. ( Guo, FY; Jing, L; Ma, Y; Wang, YL; Zhang, JZ, 2007) |
| "We investigated the effects of anesthesia with ketamine and midazolam on focal cerebral ischemia injury, and evaluated the neuroprotective properties of this combination during surgical procedures." | 7.73 | [Effects of ketamine and midazolam combination anesthesia on focal cerebral ischemia injury in rats]. ( Chen, XL; Li, J; Liu, JX; Liu, Y; Sun, JJ; Tian, YF; Zhang, PB, 2005) |
| "To compare the effects of ketamine, midazolam, thiopental, and propofol on brain ischemia by the model of oxygen-glucose deprivation (OGD) in rat cerebral cortical slices." | 7.72 | Effects of ketamine, midazolam, thiopental, and propofol on brain ischemia injury in rat cerebral cortical slices. ( Chen, HZ; Wang, ZJ; Xue, QS; Yu, BW, 2004) |
| " Sodium fluoride-induced cerebral ischemia in mice is used as a model of circulatory ischemic lesion." | 7.70 | [The use of ketamine in an experimental model of generalized cerebral ischemia]. ( Karaivanova, M; Konstantinov, S; Konstantinova, Zh; Nachkov, Ia; Stamenova, P; Vasilev, D, 1998) |
| "Neurological outcome is improved following incomplete cerebral ischemia with S(+)-ketamine." | 7.70 | High-dose S(+)-ketamine improves neurological outcome following incomplete cerebral ischemia in rats. ( Kochs, E; Mielke, L; Möllenberg, O; Reeker, W; Werner, C, 2000) |
| "After cerebral ischemia/reperfusion, the relative protein concentration of Bax was increased by 110% in control animals compared with the dexmedetomidine- and S(+)-ketamine-treated rats and by 140% compared with the sham-operated animals." | 5.32 | The effect of the alpha 2-agonist dexmedetomidine and the N-methyl-D-aspartate antagonist S(+)-ketamine on the expression of apoptosis-regulating proteins after incomplete cerebral ischemia and reperfusion in rats. ( Bachl, M; Blobner, M; Eberspächer, E; Engelhard, K; Hildt, E; Hutzler, P; Kochs, E; Werner, C, 2003) |
| "S(+) ketamine has a 2-3 times higher anesthetic potency compared with the ketamine-racemate and also shows a higher neuroprotective efficacy in vitro." | 5.31 | Neuroprotection of S(+) ketamine isomer in global forebrain ischemia. ( Heimann, A; Kempski, O; Proescholdt, M, 2001) |
| "Ketamine is a dissociative anaesthetic known to be an N-methyl-D-aspartate receptor blocker." | 5.27 | Ketamine fails to protect against ischaemic neuronal necrosis in the rat. ( Auer, RN; Jensen, ML, 1988) |
| "Altogether these data suggest that ketamine significantly improves the benefit of rtPA-induced thrombolysis after stroke." | 3.77 | Preclinical evidence toward the use of ketamine for recombinant tissue-type plasminogen activator-mediated thrombolysis under anesthesia or sedation. ( Defer, G; Gakuba, C; Gauberti, M; Hanouz, JL; Mazighi, M; Vivien, D, 2011) |
| " Both N-methyl-D-aspartic acid (NMDA) receptor antagonist (ketamine) and oxygen free radical scavenger (alpha-tocopherol) decreased AMPK activity as well as the content of GLUT4 in the plasma membrane following cerebral ischemia." | 3.76 | Oxygen free radicals regulate energy metabolism via AMPK pathway following cerebral ischemia. ( Guo, J; Hu, Y; Li, M; Lu, H; Zhao, J, 2010) |
| "To investigate the effects of ketamine pretreatment on cerebral edema following brain ischemia reperfusion injury in rats and assess the involvement of Aquaporin 4 (AQP4) expression." | 3.76 | [The effects of ketamine pretreated on cerebral edema and AQP4 expression after transient focal cerebral ischemia/reperfusion in rats]. ( Cai, SN; Zhu, SM, 2010) |
| "Ketamine is a non-competitive antagonist at N-methyl-D-aspartate (NMDA) receptors and reduces neuronal injury after cerebral ischemia by blocking the excitotoxic effects of glutamate." | 3.75 | Dose-dependent effect of S(+) ketamine on post-ischemic endogenous neurogenesis in rats. ( Engelhard, K; Kaeppel, B; Kochs, E; Lasarzik, I; Werner, C; Winkelheide, U; Winkler, J, 2009) |
| "The present study tested the effect of ketamine on the fetal reflex responses of late-gestation sheep to brachiocephalic occlusion (BCO), a stimulus that mimics the reduction in cerebral blood flow that results from severe fetal hypotension." | 3.74 | Ketamine inhibits fetal ACTH responses to cerebral hypoperfusion. ( Powers, MJ; Wood, CE, 2007) |
| "To determine if the inhibitory effects of ketamine on the extracellular signal-regulated kinase (ERK) 1/2 are involved in reduction of the hyperglycemia-exaggerated cerebral ischemic lesion, rats with normoglycemia, hyperglycemia, or hyperglycemia supplemented with ketamine were subjected to 15 min of forebrain ischemia, and then, reperfusion for 0." | 3.74 | Inhibitory effect of ketamine on phosphorylation of the extracellular signal-regulated kinase 1/2 following brain ischemia and reperfusion in rats with hyperglycemia. ( Guo, FY; Jing, L; Ma, Y; Wang, YL; Zhang, JZ, 2007) |
| "We investigated the effects of anesthesia with ketamine and midazolam on focal cerebral ischemia injury, and evaluated the neuroprotective properties of this combination during surgical procedures." | 3.73 | [Effects of ketamine and midazolam combination anesthesia on focal cerebral ischemia injury in rats]. ( Chen, XL; Li, J; Liu, JX; Liu, Y; Sun, JJ; Tian, YF; Zhang, PB, 2005) |
| "To compare the effects of ketamine, midazolam, thiopental, and propofol on brain ischemia by the model of oxygen-glucose deprivation (OGD) in rat cerebral cortical slices." | 3.72 | Effects of ketamine, midazolam, thiopental, and propofol on brain ischemia injury in rat cerebral cortical slices. ( Chen, HZ; Wang, ZJ; Xue, QS; Yu, BW, 2004) |
| " Pretreatment with N-methyl-D-aspartate (NMDA) receptor antagonist ketamine, non-NMDA receptor antagonist DNQX, or NF-kappaB inhibitor PDTC decreased the IKK activity following brain ischemia 30 min." | 3.72 | Modulation of IkappaB kinase autophosphorylation and activity following brain ischemia. ( Shen, WH; Zhang, CY; Zhang, GY, 2003) |
| "The effects of three drugs including ketamine(KT), a noncompetitive antagonist of NMDA receptor (NR), nifedipine(ND), a voltage gated calcium channel (VGCC) antagonist and 6, 7dinitroquinoxaline -2, 3-dione(DNQX), a non-NMDA receptor antagonist on the contents of phospho-tyrosine proteins (p-tyr-pr) in the synaptosomal(P2), the crude membrane (P3), and the cytosolic (S3) fractions of hippocampus in forebrain ischemia of mongolian gerbils were studied." | 3.71 | [Effects of ischemia/reperfusion on the phosphotyrosine proteins contents in hippocampus]. ( Gui, ZH; Li, Y; Pei, L; Zhang, GY; Zhu, ZM, 2001) |
| " Sodium fluoride-induced cerebral ischemia in mice is used as a model of circulatory ischemic lesion." | 3.70 | [The use of ketamine in an experimental model of generalized cerebral ischemia]. ( Karaivanova, M; Konstantinov, S; Konstantinova, Zh; Nachkov, Ia; Stamenova, P; Vasilev, D, 1998) |
| "Neurological outcome is improved following incomplete cerebral ischemia with S(+)-ketamine." | 3.70 | High-dose S(+)-ketamine improves neurological outcome following incomplete cerebral ischemia in rats. ( Kochs, E; Mielke, L; Möllenberg, O; Reeker, W; Werner, C, 2000) |
| "The increases of glutamate, aspartate, glycine, and glutamine induced by acute global cerebral ischemia may constitute the biochemical basis of ischemic brain damage." | 3.70 | Alterations of amino acid levels from striatum, hippocampus, and cerebral cortex induced by global cerebral ischemia in gerbil. ( Hu, G; Rao, MR; Tang, XC; Wang, H, 2000) |
| " Using an in vitro model of transient brain ischemia, we investigated possible protective effects of NMDA receptor antagonists ketamine or MK-801 and of calmidazolium, an inhibitor of intracellular Ca2(+)-activated proteins." | 3.68 | Ischemic brain injury in vitro: protective effects of NMDA receptor antagonists and calmidazolium. ( Becker, GL; Landers, DF; Pohorecki, R; Reilly, PJ, 1990) |
| "Survival rates following incomplete brain ischemia induced during pentobarbital anesthesia were significantly higher in mice with a minor brain injury, inflicted one week before, than in those given a sham operation." | 3.67 | Effects of pentobarbital and ketamine on brain injury-induced anti-ischemic activity. ( Endoh, H; Fujiwara, N; Ohama, E; Shimoji, K; Taga, K; Takahata, Y, 1987) |
| "Ketamine is said to increase intracranial pressure (ICP), cerebral blood flow (CBF) and cerebral metabolic rate for oxygen (CMRO2) and hence to be unsuitable for neuroanaesthesia." | 2.39 | [Cerebral neuroprotection and ketamine]. ( Jantzen, JP, 1994) |
| " Twenty-four hours after ischemia, five rats in each group were killed by injecting the above dosage of ketamine or ketamine-midazolam intraperitoneally and infarct size was measured." | 1.33 | Effects of ketamine-midazolam anesthesia on the expression of NMDA and AMPA receptor subunit in the peri-infarction of rat brain. ( Liu, Y; Qiu, SD; Tian, YF; Wang, Y; Zhang, PB; Zhang, YL, 2006) |
| "After cerebral ischemia/reperfusion, the relative protein concentration of Bax was increased by 110% in control animals compared with the dexmedetomidine- and S(+)-ketamine-treated rats and by 140% compared with the sham-operated animals." | 1.32 | The effect of the alpha 2-agonist dexmedetomidine and the N-methyl-D-aspartate antagonist S(+)-ketamine on the expression of apoptosis-regulating proteins after incomplete cerebral ischemia and reperfusion in rats. ( Bachl, M; Blobner, M; Eberspächer, E; Engelhard, K; Hildt, E; Hutzler, P; Kochs, E; Werner, C, 2003) |
| "Ketamine might suppress both peaks described above, but N-acetylcysteine, a free radical scavenger, was only able to partly reduce the peak activation elicited by 6 h reperfusion." | 1.32 | Free radicals are involved in continuous activation of nonreceptor tyrosine protein kinase c-Src after ischemia/reperfusion in rat hippocampus. ( Guo, J; Meng, F; Zhang, G; Zhang, Q, 2003) |
| "S(+) ketamine has a 2-3 times higher anesthetic potency compared with the ketamine-racemate and also shows a higher neuroprotective efficacy in vitro." | 1.31 | Neuroprotection of S(+) ketamine isomer in global forebrain ischemia. ( Heimann, A; Kempski, O; Proescholdt, M, 2001) |
| "Post-treatment with ketamine was associated with partial restoration of energy stores and amino acid content of the left cerebral hemisphere." | 1.30 | Effect of ketamine on hypoxic-ischemic brain damage in newborn rats. ( Avgovstides-Savvopoulou, P; Guiba-Tziampiri, O; Karkavelas, G; Loizidis, T; Soubasi, V; Spandou, E, 1999) |
| "When procaine was used as a local anesthetic agent during surgery, damage to catecholamine-, GTP-, or forskolin-activated adenylate cyclase was evident to varying degrees in the frontal cortex, hippocampus or olfactory tubercle, but not in the nucleus accumbens and olfactory bulb of gerbils subjected to 60-min stroke followed by 15 or 150 min of recirculation." | 1.27 | Regional cyclic AMP systems during secondary ischemia in gerbils: influence of anesthetic agents. ( Callahan, AS; Christie-Pope, BC; Medina, MA; Palmer, GC; Palmer, SJ; Poulakos, L, 1984) |
| "Ketamine is a dissociative anaesthetic known to be an N-methyl-D-aspartate receptor blocker." | 1.27 | Ketamine fails to protect against ischaemic neuronal necrosis in the rat. ( Auer, RN; Jensen, ML, 1988) |
| "Focal cerebral ischemia initiates multiple detrimental effects in the brain." | 1.27 | Indomethacin-mediated improvement following middle cerebral artery occlusion in cats. Effects of anesthesia. ( Dempsey, RJ; Donaldson, DL; Meyer, KL; Roy, MW, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (15.38) | 18.7374 |
| 1990's | 15 (23.08) | 18.2507 |
| 2000's | 29 (44.62) | 29.6817 |
| 2010's | 10 (15.38) | 24.3611 |
| 2020's | 1 (1.54) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, G | 1 |
| Kamat, PK | 1 |
| Ahmad, AS | 1 |
| Doré, S | 1 |
| Ward, JM | 1 |
| Buslov, AM | 1 |
| Vallender, EJ | 1 |
| Welling, L | 1 |
| Welling, MS | 1 |
| Teixeira, MJ | 1 |
| Figueiredo, EG | 1 |
| Ulbrich, F | 1 |
| Eisert, L | 1 |
| Buerkle, H | 1 |
| Goebel, U | 1 |
| Schallner, N | 1 |
| Zhao, H | 1 |
| Mayhan, WG | 1 |
| Sun, H | 1 |
| Winkelheide, U | 1 |
| Lasarzik, I | 1 |
| Kaeppel, B | 1 |
| Winkler, J | 1 |
| Werner, C | 5 |
| Kochs, E | 5 |
| Engelhard, K | 3 |
| Hudetz, JA | 1 |
| Pagel, PS | 1 |
| Li, M | 1 |
| Zhao, J | 1 |
| Hu, Y | 1 |
| Lu, H | 2 |
| Guo, J | 3 |
| Cao, Q | 1 |
| Qian, M | 1 |
| Wang, XF | 1 |
| Wang, B | 1 |
| Wu, HW | 1 |
| Zhu, XJ | 1 |
| Wang, YW | 1 |
| Cai, SN | 1 |
| Zhu, SM | 1 |
| Pei, L | 2 |
| Li, Y | 2 |
| Zhang, GY | 5 |
| Gui, ZH | 1 |
| Zhu, ZM | 1 |
| Gakuba, C | 1 |
| Gauberti, M | 1 |
| Mazighi, M | 1 |
| Defer, G | 1 |
| Hanouz, JL | 1 |
| Vivien, D | 1 |
| Shu, L | 1 |
| Li, T | 1 |
| Han, S | 1 |
| Ji, F | 1 |
| Pan, C | 1 |
| Zhang, B | 1 |
| Li, J | 2 |
| Krysl, D | 1 |
| Deykun, K | 1 |
| Lambert, L | 1 |
| Pokorny, J | 1 |
| Mares, J | 1 |
| Zhang, C | 2 |
| Shen, W | 2 |
| Zhang, G | 6 |
| Eberspächer, E | 1 |
| Bachl, M | 1 |
| Blobner, M | 1 |
| Hildt, E | 1 |
| Hutzler, P | 1 |
| Shen, WH | 2 |
| Zhang, CY | 2 |
| Tian, H | 1 |
| Li, H | 2 |
| Zhang, Q | 3 |
| Meng, F | 1 |
| Lim, YJ | 1 |
| Huang, Y | 1 |
| Fang, H | 1 |
| Zuo, Z | 1 |
| Xue, QS | 1 |
| Yu, BW | 1 |
| Wang, ZJ | 1 |
| Chen, HZ | 1 |
| Basagan-Mogol, E | 1 |
| Büyükuysal, RL | 1 |
| Korfali, G | 1 |
| Yin, XH | 1 |
| Zhang, QG | 1 |
| Miao, B | 1 |
| Zhang, PB | 2 |
| Liu, Y | 3 |
| Chen, XL | 1 |
| Tian, YF | 2 |
| Sun, JJ | 1 |
| Liu, JX | 1 |
| Yoshizawa, K | 1 |
| Oishi, Y | 1 |
| Matsumoto, M | 1 |
| Nyska, A | 1 |
| Zhang, YL | 1 |
| Qiu, SD | 1 |
| Wang, Y | 1 |
| Powers, MJ | 1 |
| Wood, CE | 1 |
| Zhang, JZ | 1 |
| Jing, L | 1 |
| Guo, FY | 1 |
| Ma, Y | 1 |
| Wang, YL | 1 |
| Christie-Pope, BC | 1 |
| Palmer, GC | 1 |
| Poulakos, L | 1 |
| Medina, MA | 1 |
| Callahan, AS | 1 |
| Palmer, SJ | 1 |
| Shiu, GK | 1 |
| Nemoto, EM | 1 |
| Nemmer, J | 1 |
| Edgar, AD | 1 |
| Strosznajder, J | 1 |
| Horrocks, LA | 1 |
| Kim, KW | 1 |
| Kim, DC | 1 |
| Kim, YH | 1 |
| Eun, YA | 1 |
| Kim, HI | 1 |
| Cho, KP | 1 |
| Jantzen, JP | 1 |
| Renis, M | 1 |
| Di Giacomo, C | 1 |
| Sorrenti, V | 1 |
| Russo, A | 1 |
| La Delfa, C | 1 |
| Reale, S | 1 |
| Barcellona, ML | 1 |
| Vanella, A | 1 |
| Sharp, FR | 1 |
| Kinouchi, H | 1 |
| Koistinaho, J | 1 |
| Chan, PH | 2 |
| Sagar, SM | 1 |
| Reeker, W | 2 |
| Kempski, O | 2 |
| Proescholdt, M | 2 |
| Fitzal, S | 1 |
| Vasilev, D | 1 |
| Konstantinov, S | 1 |
| Konstantinova, Zh | 1 |
| Nachkov, Ia | 1 |
| Karaivanova, M | 1 |
| Stamenova, P | 1 |
| Spandou, E | 1 |
| Karkavelas, G | 1 |
| Soubasi, V | 1 |
| Avgovstides-Savvopoulou, P | 1 |
| Loizidis, T | 1 |
| Guiba-Tziampiri, O | 1 |
| Miura, Y | 1 |
| Mackensen, GB | 1 |
| Nellgård, B | 1 |
| Pearlstein, RD | 1 |
| Bart, RD | 1 |
| Dexter, F | 1 |
| Warner, DS | 1 |
| Möllenberg, O | 1 |
| Mielke, L | 1 |
| Mathews, KS | 1 |
| Toner, CC | 1 |
| McLaughlin, DP | 1 |
| Stamford, JA | 1 |
| Mortier, E | 1 |
| Struys, M | 1 |
| Herregods, L | 1 |
| Heimann, A | 1 |
| Gao, C | 1 |
| Hou, X | 1 |
| Tang, XC | 1 |
| Rao, MR | 1 |
| Hu, G | 1 |
| Wang, H | 1 |
| Chang, ML | 1 |
| Yang, J | 1 |
| Kem, S | 1 |
| Klaidman, L | 1 |
| Sugawara, T | 1 |
| Adams, JD | 1 |
| Hendryk, S | 1 |
| Jedrzejowska-Szypulka, H | 1 |
| Jośko, J | 1 |
| Jarzab, B | 1 |
| Döhler, KD | 1 |
| Rischke, R | 1 |
| Rami, A | 1 |
| Bachmann, U | 1 |
| Rabié, A | 1 |
| Krieglstein, J | 3 |
| Hoffman, WE | 1 |
| Pelligrino, D | 1 |
| Albrecht, RF | 1 |
| Schulte am Esch, J | 1 |
| Pohorecki, R | 1 |
| Becker, GL | 1 |
| Reilly, PJ | 1 |
| Landers, DF | 1 |
| Silver, IA | 1 |
| Erecińska, M | 1 |
| Kasaba, T | 1 |
| Saito, Y | 1 |
| Sakura, S | 1 |
| Kosaka, Y | 1 |
| Petersen, EN | 1 |
| Ahlemeyer, B | 1 |
| Jensen, ML | 1 |
| Auer, RN | 1 |
| Shimoji, K | 1 |
| Takahata, Y | 1 |
| Fujiwara, N | 1 |
| Endoh, H | 1 |
| Taga, K | 1 |
| Ohama, E | 1 |
| Bielenberg, GW | 1 |
| Beck, T | 1 |
| Sauer, D | 1 |
| Burniol, M | 1 |
| Roquefeuil, B | 1 |
| Dempsey, RJ | 1 |
| Roy, MW | 1 |
| Meyer, KL | 1 |
| Donaldson, DL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| S-ketamine for Cortical Spreading Depolarisation in Patients With Severe Acute Brain Injury[NCT05095857] | Phase 4 | 400 participants (Anticipated) | Interventional | 2023-09-15 | Recruiting | ||
| Effect of Ketamine Versus Sufentanil on Cerebral Glutamate After Traumatic Brain Injury : a Randomized, Double-blinded, Microdialysis Study[NCT02232347] | Phase 2 | 20 participants (Anticipated) | Interventional | 2014-10-31 | Not yet recruiting | ||
| Changes of the Short Portable Mental Status Questionnaire (SPMSQ-E) After Ketamine Administration on Ophthalmic Surgery in Geriatric Population.[NCT02049411] | Phase 2 | 80 participants (Actual) | Interventional | 2013-06-30 | Completed | ||
| Effets de la kétamine en Association Avec le Rt-PA au Cours de l'Infarctus cérébral Aigu: étude Pilote contrôlée randomisée en Double Aveugle Avec critère de Jugement Radiologique[NCT02258204] | Phase 1/Phase 2 | 50 participants (Anticipated) | Interventional | 2015-03-31 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 reviews available for ketamine and Brain Ischemia
| Article | Year |
|---|---|
Neuroprotection by ketamine: a review of the experimental and clinical evidence.
Topics: Brain Ischemia; Cardiopulmonary Bypass; Cerebrovascular Circulation; Excitatory Amino Acid Antagonis | 2010 |
Neuroprotection by ketamine: a review of the experimental and clinical evidence.
Topics: Brain Ischemia; Cardiopulmonary Bypass; Cerebrovascular Circulation; Excitatory Amino Acid Antagonis | 2010 |
Neuroprotection by ketamine: a review of the experimental and clinical evidence.
Topics: Brain Ischemia; Cardiopulmonary Bypass; Cerebrovascular Circulation; Excitatory Amino Acid Antagonis | 2010 |
Neuroprotection by ketamine: a review of the experimental and clinical evidence.
Topics: Brain Ischemia; Cardiopulmonary Bypass; Cerebrovascular Circulation; Excitatory Amino Acid Antagonis | 2010 |
[Cerebral neuroprotection and ketamine].
Topics: Animals; Brain Diseases; Brain Injuries; Brain Ischemia; Humans; Hypoxia, Brain; Ketamine; Time Fact | 1994 |
HSP70 heat shock gene regulation during ischemia.
Topics: Animals; Brain Ischemia; Dizocilpine Maleate; Gene Expression Regulation; Heat-Shock Proteins; Human | 1993 |
[Ketamine racemate and S-(+)-ketamine. Cerebrovascular effects and neuroprotection following focal ischemia].
Topics: Animals; Brain Ischemia; Cerebrovascular Circulation; Excitatory Amino Acid Antagonists; Humans; Ket | 1997 |
[Effect of ketamine on global cerebral ischemia].
Topics: Animals; Brain Ischemia; Excitatory Amino Acid Antagonists; Ketamine; Neuroprotective Agents | 1997 |
[Ketamine and neuroprotection. Clinical outlook].
Topics: Animals; Brain Ischemia; Excitatory Amino Acid Antagonists; Humans; Intracranial Pressure; Ketamine; | 1997 |
Therapeutic coma or neuroprotection by anaesthetics.
Topics: Anesthetics; Animals; Barbiturates; Brain; Brain Ischemia; Cardiopulmonary Bypass; Drug Evaluation; | 2000 |
58 other studies available for ketamine and Brain Ischemia
| Article | Year |
|---|---|
Distinctive effect of anesthetics on the effect of limb remote ischemic postconditioning following ischemic stroke.
Topics: Analgesics; Anesthetics; Animals; Brain Infarction; Brain Ischemia; Extremities; Halothane; Infarcti | 2020 |
Twinning and survivorship of captive common marmosets (Callithrix jacchus) and cotton-top tamarins (Saguinus oedipus).
Topics: Animals; Animals, Laboratory; Brain Ischemia; Bupivacaine; Callithrix; Electroencephalography; Eutha | 2014 |
Cortical spread depolarization and ketamine: a revival of an old drug or a new era of neuroprotective drugs?
Topics: Brain Ischemia; Cerebrovascular Circulation; Cortical Spreading Depression; Humans; Intracranial Hem | 2015 |
Propofol, but not ketamine or midazolam, exerts neuroprotection after ischaemic injury by inhibition of Toll-like receptor 4 and nuclear factor kappa-light-chain-enhancer of activated B-cell signalling: A combined in vitro and animal study.
Topics: Analgesics; Animals; B-Lymphocytes; Brain Ischemia; Cell Line, Tumor; Dose-Response Relationship, Dr | 2016 |
A modified suture technique produces consistent cerebral infarction in rats.
Topics: Analysis of Variance; Anesthetics; Animals; Brain Ischemia; Cerebrovascular Circulation; Disease Mod | 2008 |
Dose-dependent effect of S(+) ketamine on post-ischemic endogenous neurogenesis in rats.
Topics: Animals; Brain Ischemia; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Ketami | 2009 |
Oxygen free radicals regulate energy metabolism via AMPK pathway following cerebral ischemia.
Topics: alpha-Tocopherol; AMP-Activated Protein Kinases; Analysis of Variance; Animals; Blotting, Western; B | 2010 |
Negative feedback regulation of Raf/MEK/ERK cascade after sublethal cerebral ischemia in the rat hippocampus.
Topics: Animals; Brain Ischemia; Calcium; Cantharidin; Enzyme Activation; Enzyme Inhibitors; Excitatory Amin | 2011 |
[The effects of ketamine pretreated on cerebral edema and AQP4 expression after transient focal cerebral ischemia/reperfusion in rats].
Topics: Animals; Aquaporin 4; Brain; Brain Edema; Brain Ischemia; Ischemic Preconditioning; Ketamine; Male; | 2010 |
[Effects of ischemia/reperfusion on the phosphotyrosine proteins contents in hippocampus].
Topics: Animals; Brain Ischemia; Calcium Channel Blockers; Calcium Channels; Excitatory Amino Acid Antagonis | 2001 |
Preclinical evidence toward the use of ketamine for recombinant tissue-type plasminogen activator-mediated thrombolysis under anesthesia or sedation.
Topics: Anesthetics, Dissociative; Animals; Brain Ischemia; Fibrinolytic Agents; Ketamine; Magnetic Resonanc | 2011 |
Inhibition of neuron-specific CREB dephosphorylation is involved in propofol and ketamine-induced neuroprotection against cerebral ischemic injuries of mice.
Topics: Animals; Blotting, Western; Brain Ischemia; Cyclic AMP Response Element-Binding Protein; Electrophor | 2012 |
Perifocal and remote blood-brain barrier disruption in cortical photothrombotic ischemic lesion and its modulation by the choice of anesthesia.
Topics: Adrenergic alpha-2 Receptor Agonists; Anesthetics; Animals; Blood-Brain Barrier; Brain Ischemia; Exc | 2012 |
N-methyl-D-aspartate receptor and L-type voltage-gated Ca(2+) channel antagonists suppress the release of cytochrome c and the expression of procaspase-3 in rat hippocampus after global brain ischemia.
Topics: Animals; Brain Ischemia; Calcium Channel Blockers; Calcium Channels, L-Type; Caspase 3; Caspase Inhi | 2002 |
The effect of the alpha 2-agonist dexmedetomidine and the N-methyl-D-aspartate antagonist S(+)-ketamine on the expression of apoptosis-regulating proteins after incomplete cerebral ischemia and reperfusion in rats.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Animals; Apoptosis; Blood Gas Analy | 2003 |
Modulation of IkappaB kinase autophosphorylation and activity following brain ischemia.
Topics: Animals; Brain Ischemia; Excitatory Amino Acid Antagonists; Hippocampus; I-kappa B Kinase; Ketamine; | 2003 |
Antioxidant NAC and AMPA/KA receptor antagonist DNQX inhibited JNK3 activation following global ischemia in rat hippocampus.
Topics: Acetylcysteine; Animals; Brain Ischemia; Calcium Channel Blockers; Excitatory Amino Acid Antagonists | 2003 |
Signal transducer and activator of transcription-3 activation is mediated by N-methyl-D-aspartate receptor and L-type voltage-gated Ca2+ channel during cerebral ischemia in rat hippocampus.
Topics: Active Transport, Cell Nucleus; Animals; Brain Ischemia; Calcium Channel Blockers; Calcium Channels, | 2003 |
Free radicals are involved in continuous activation of nonreceptor tyrosine protein kinase c-Src after ischemia/reperfusion in rat hippocampus.
Topics: Acetylcysteine; Animals; Brain Ischemia; CSK Tyrosine-Protein Kinase; Dose-Response Relationship, Dr | 2003 |
Effects of local and intravenous anesthetics on the activity of glutamate transporter type 2.
Topics: Anesthetics, Intravenous; Anesthetics, Local; Animals; Brain Ischemia; Bupivacaine; Cell Membrane; E | 2003 |
Effects of ketamine, midazolam, thiopental, and propofol on brain ischemia injury in rat cerebral cortical slices.
Topics: Anesthetics, Intravenous; Animals; Brain Ischemia; Cell Hypoxia; Cerebral Cortex; Glucose; In Vitro | 2004 |
Ischemia-induced release of cytochrome c from mitochondria and up-regulation of Bcl-2 expression in rat hippocampus.
Topics: Animals; Brain Ischemia; Calcium Channel Blockers; Calcium Channels, L-Type; Cytochromes c; Cytosol; | 2004 |
Effects of ketamine and thiopental on ischemia reoxygenation-induced LDH leakage and amino acid release from rat striatal slices.
Topics: Amino Acids; Anesthetics, Dissociative; Anesthetics, Intravenous; Animals; Brain Ischemia; Female; I | 2005 |
Neuroprotective effects of preconditioning ischaemia on ischaemic brain injury through inhibition of mixed-lineage kinase 3 via NMDA receptor-mediated Akt1 activation.
Topics: Animals; Blotting, Western; Brain; Brain Ischemia; Cell Death; Chromones; Dimethyl Sulfoxide; Diseas | 2005 |
[Effects of ketamine and midazolam combination anesthesia on focal cerebral ischemia injury in rats].
Topics: Anesthesia; Anesthetics, Combined; Animals; Brain Ischemia; Ketamine; Male; Midazolam; Neuroprotecti | 2005 |
Ischemic brain damage after ketamine and xylazine treatment in a young laboratory monkey (Macaca fascicularis).
Topics: Anesthesia; Animals; Brain Ischemia; Cerebellar Cortex; Cerebral Cortex; Corpus Striatum; Female; Hi | 2005 |
Effects of ketamine-midazolam anesthesia on the expression of NMDA and AMPA receptor subunit in the peri-infarction of rat brain.
Topics: Anesthetics, Dissociative; Animals; Brain Chemistry; Brain Infarction; Brain Ischemia; Immunohistoch | 2006 |
Ketamine inhibits fetal ACTH responses to cerebral hypoperfusion.
Topics: Adrenocorticotropic Hormone; Anesthetics, Dissociative; Animals; Blood Pressure; Brachiocephalic Tru | 2007 |
Inhibitory effect of ketamine on phosphorylation of the extracellular signal-regulated kinase 1/2 following brain ischemia and reperfusion in rats with hyperglycemia.
Topics: Animals; Apoptosis; Brain Ischemia; Cerebral Cortex; Disease Models, Animal; Excitatory Amino Acid A | 2007 |
Regional cyclic AMP systems during secondary ischemia in gerbils: influence of anesthetic agents.
Topics: Adenylyl Cyclases; Animals; Brain; Brain Ischemia; Cyclic AMP; Evoked Potentials, Visual; Fasting; F | 1984 |
Dose of thiopental, pentobarbital, and phenytoin for maximal therapeutic effects in cerebral ischemic anoxia.
Topics: Animals; Brain Chemistry; Brain Ischemia; Fatty Acids, Nonesterified; Female; Hypoxia, Brain; Ketami | 1983 |
Activation of ethanolamine phospholipase A2 in Brain during ischemia.
Topics: Animals; Brain; Brain Ischemia; Carotid Arteries; Gerbillinae; Ketamine; Ligation; Pentobarbital; Ph | 1982 |
Ca2+-dependent and -independent mechanisms of ischaemia-evoked release of [3H]-dopamine from rat striatal slices.
Topics: Animals; Brain Ischemia; Calcium; Calcium Channel Blockers; Corpus Striatum; Culture Techniques; Cyc | 1995 |
Heat shock proteins following rat cerebral ischemic/reperfusion episode: effect of ketamine.
Topics: Animals; Brain Ischemia; Cerebral Cortex; Disease Models, Animal; Hippocampus; HSP70 Heat-Shock Prot | 1994 |
[The use of ketamine in an experimental model of generalized cerebral ischemia].
Topics: Animals; Brain Ischemia; Disease Models, Animal; Drug Evaluation, Preclinical; Excitatory Amino Acid | 1998 |
Effect of ketamine on hypoxic-ischemic brain damage in newborn rats.
Topics: Adenosine Triphosphate; Amino Acids; Animals; Animals, Newborn; Body Weight; Brain; Brain Ischemia; | 1999 |
Effects of isoflurane, ketamine, and fentanyl/N2O on concentrations of brain and plasma catecholamines during near-complete cerebral ischemia in the rat.
Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Brain Ischemia; Catecholamines; Fentanyl | 1999 |
High-dose S(+)-ketamine improves neurological outcome following incomplete cerebral ischemia in rats.
Topics: Animals; Brain Ischemia; Catecholamines; Dose-Response Relationship, Drug; Excitatory Amino Acid Ant | 2000 |
Comparison of ketamine stereoisomers on tissue metabolic activity in an in vitro model of global cerebral ischaemia.
Topics: Animals; Brain Ischemia; Corpus Striatum; In Vitro Techniques; Ketamine; Male; Models, Biological; R | 2001 |
Neuroprotection of S(+) ketamine isomer in global forebrain ischemia.
Topics: Animals; Brain Ischemia; Cell Death; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagon | 2001 |
NMDA receptor activation results in tyrosine phosphorylation of NMDA receptor subunit 2A(NR2A) and interaction of Pyk2 and Src with NR2A after transient cerebral ischemia and reperfusion.
Topics: Animals; Brain Ischemia; Excitatory Amino Acid Antagonists; Focal Adhesion Kinase 2; Hippocampus; Im | 2001 |
Alterations of amino acid levels from striatum, hippocampus, and cerebral cortex induced by global cerebral ischemia in gerbil.
Topics: Animals; Brain; Brain Ischemia; Cerebral Cortex; Corpus Striatum; Excitatory Amino Acid Antagonists; | 2000 |
Nicotinamide and ketamine reduce infarct volume and DNA fragmentation in rats after brain ischemia and reperfusion.
Topics: Animals; Brain Ischemia; Cerebral Infarction; DNA Fragmentation; Excitatory Amino Acid Antagonists; | 2002 |
Nuclear factor kappaB activation is mediated by NMDA and non-NMDA receptor and L-type voltage-gated Ca(2+) channel following severe global ischemia in rat hippocampus.
Topics: Animals; Brain Ischemia; Calcium Channel Blockers; Calcium Channels, L-Type; Cytoplasm; Excitatory A | 2002 |
Influence of the corticotropin releasing hormone (CRH) on the brain-blood barrier permeability in cerebral ischemia in rats.
Topics: Animals; Blood-Brain Barrier; Brain Ischemia; Catheterization; Cisterna Magna; Coloring Agents; Cort | 2002 |
[Effect of ischemia/reperfusion on the phosphorylation of synaptosomal tyrosine of hippocampus of Mongolian gerbils].
Topics: Animals; Brain Ischemia; Calcium Channels, L-Type; Gerbillinae; Hippocampus; Ketamine; Nifedipine; P | 2000 |
Activated astrocytes, but not pyramidal cells, increase glucose utilization in rat hippocampal CA1 subfield after ischemia.
Topics: Animals; Astrocytes; Autoradiography; Brain Ischemia; Glucose; Hippocampus; Immunoenzyme Techniques; | 1992 |
Ketamine decreases plasma catecholamines and improves outcome from incomplete cerebral ischemia in rats.
Topics: Animals; Blood Glucose; Blood Pressure; Brain; Brain Ischemia; Cerebrovascular Circulation; Electroe | 1992 |
Ischemic brain injury in vitro: protective effects of NMDA receptor antagonists and calmidazolium.
Topics: Adenosine Triphosphate; Animals; Brain Ischemia; Dizocilpine Maleate; Hippocampus; Imidazoles; In Vi | 1990 |
Intracellular and extracellular changes of [Ca2+] in hypoxia and ischemia in rat brain in vivo.
Topics: Animals; Brain Ischemia; Calcium; Calcium Channels; Cerebral Cortex; Dibenzocycloheptenes; Dizocilpi | 1990 |
[The effects of thiamylal, ketamine and nicardipine on the hippocampal theta waves produced by cerebral ischemia in cats].
Topics: Animals; Brain Ischemia; Cats; Hippocampus; Ketamine; Nicardipine; Theta Rhythm; Thiamylal | 1990 |
Anti-ischaemic effects of indomethacin and ketamine on hippocampus neurones in Mongolian gerbils.
Topics: Animals; Brain Ischemia; Carotid Arteries; Female; Gerbillinae; Hippocampus; Indomethacin; Ketamine; | 1989 |
Testing drug effects against hypoxic damage of cultured neurons during long-term recovery.
Topics: Adenosine Triphosphate; Animals; Anticonvulsants; Brain Ischemia; Cell Count; Cell Survival; Cells, | 1989 |
Ketamine fails to protect against ischaemic neuronal necrosis in the rat.
Topics: Animals; Brain; Brain Ischemia; Cerebral Cortex; Hippocampus; Ketamine; Male; Necrosis; Rats; Rats, | 1988 |
Effects of pentobarbital and ketamine on brain injury-induced anti-ischemic activity.
Topics: Anesthesia; Animals; Brain Injuries; Brain Ischemia; Cerebrovascular Circulation; Ketamine; Male; Mi | 1987 |
Effects of cerebroprotective agents on cerebral blood flow and on postischemic energy metabolism in the rat brain.
Topics: Animals; Brain; Brain Ischemia; Calcium Channel Blockers; Cerebrovascular Circulation; Energy Metabo | 1987 |
[Cerebral ischemia, anesthetic agents and cerebral metabolic protection].
Topics: Alfaxalone Alfadolone Mixture; Anesthetics; Barbiturates; Brain; Brain Ischemia; Diazepam; Etomidate | 1987 |
Indomethacin-mediated improvement following middle cerebral artery occlusion in cats. Effects of anesthesia.
Topics: Animals; Brain Edema; Brain Ischemia; Cats; Cerebral Arteries; Cerebrovascular Circulation; Evoked P | 1985 |