ketamine has been researched along with Drug Overdose in 23 studies
Ketamine: A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.
ketamine : A member of the class of cyclohexanones in which one of the hydrogens at position 2 is substituted by a 2-chlorophenyl group, while the other is substituted by a methylamino group.
Drug Overdose: Accidental or deliberate use of a medication or street drug in excess of normal dosage.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Ketamine was present in the blood of 90." | 1.62 | Characteristics and circumstances of death related to the self-administration of ketamine. ( Darke, S; Duflou, J; Farrell, M; Lappin, J; Peacock, A, 2021) |
| "Ketamine is a dissociative anesthetic commonly used for procedural sedation owing to its perceived favorable safety profile." | 1.62 | Massive Iatrogenic Pediatric Ketamine Overdose With Serial Levels and Minimal Morbidity. ( Bowman, CF; Marx, J; Pruitt, B; Thornton, SL, 2021) |
| "Treatment with carisoprodol and phenobarbital provided additional benefit and can be considered in cases of severe carisoprodol withdrawal." | 1.46 | Severe Carisoprodol Withdrawal After a 14-Year Addiction and Acute Overdose. ( Benowitz, NL; Horng, H; Smollin, CG; Vo, KT, 2017) |
| "Ketamine was administered for agitation on 32 visits involving 27 patients." | 1.42 | Ketamine use for acute agitation in the emergency department. ( Campillo, A; Castillo, EM; Davie, T; Hopper, AB; Vilke, GM; Wilson, MP, 2015) |
| "Ketamine is a safe and effective sedative for diagnostic or therapeutic procedures in the Emergency Department." | 1.35 | Prolonged sedation and airway complications after administration of an inadvertent ketamine overdose in emergency department. ( Benito, J; Capapé, S; García, S; Mintegui, S; Mora, E; Santiago, M, 2008) |
| "Ketamine is an anaesthetic agent primarily used in veterinary medicine and paediatrics." | 1.31 | [New drugs at "rave parties": ketamine and prolintane]. ( Canal, M; Gaulier, JM; Lachâtre, G; Marquet, P; Pradeille, JL, 2002) |
| " In 5 children, the dosing error was not discovered until late in the sedation, often when the child was not waking at the expected time." | 1.30 | Inadvertent ketamine overdose in children: clinical manifestations and outcome. ( Carlson, D; Clark, R; Cohen, M; Green, SM; Hostetler, MA; Rothrock, SG, 1999) |
| "Nor-Ketamine was detected in all samples, but not quantified." | 1.29 | A fatal ketamine poisoning. ( Licata, M; Pierini, G; Popoli, G, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (8.70) | 18.2507 |
| 2000's | 5 (21.74) | 29.6817 |
| 2010's | 12 (52.17) | 24.3611 |
| 2020's | 4 (17.39) | 2.80 |
| Authors | Studies |
|---|---|
| Tanaka, R | 1 |
| Kawamura, M | 1 |
| Mizutani, S | 1 |
| Hakamatsuka, T | 1 |
| Kikura-Hanajiri, R | 1 |
| Parker, LA | 1 |
| Krebs, K | 1 |
| Pan, PL | 1 |
| Varner, KM | 1 |
| Hoddinott, KL | 1 |
| Darke, S | 1 |
| Duflou, J | 1 |
| Farrell, M | 1 |
| Peacock, A | 1 |
| Lappin, J | 1 |
| Rech, MA | 1 |
| Barbas, B | 1 |
| Chaney, W | 1 |
| Greenhalgh, E | 1 |
| Turck, C | 1 |
| Lee, CW | 1 |
| Chao, YY | 1 |
| Shiea, J | 1 |
| Shen, JH | 1 |
| Lee, HH | 1 |
| Chen, BH | 1 |
| Warner, LL | 1 |
| Smischney, N | 1 |
| Theofel, N | 1 |
| Möller, P | 1 |
| Vejmelka, E | 1 |
| Kastner, K | 1 |
| Roscher, S | 1 |
| Scholtis, S | 1 |
| Tsokos, M | 1 |
| Bowman, CF | 1 |
| Pruitt, B | 1 |
| Marx, J | 1 |
| Thornton, SL | 1 |
| Gomila, I | 1 |
| Leciñena, MÁ | 1 |
| Elorza, MÁ | 1 |
| Pastor, Y | 1 |
| Sahuquillo, L | 1 |
| Servera, M | 1 |
| Puiguriguer, J | 1 |
| Barcelo, B | 1 |
| Sullivan, RW | 1 |
| Ryzewski, M | 1 |
| Holland, MG | 1 |
| Marraffa, JM | 1 |
| Hopper, AB | 1 |
| Vilke, GM | 1 |
| Castillo, EM | 1 |
| Campillo, A | 1 |
| Davie, T | 1 |
| Wilson, MP | 1 |
| Wallach, J | 1 |
| Kang, H | 1 |
| Colestock, T | 1 |
| Morris, H | 1 |
| Bortolotto, ZA | 1 |
| Collingridge, GL | 1 |
| Lodge, D | 1 |
| Halberstadt, AL | 1 |
| Brandt, SD | 1 |
| Adejare, A | 1 |
| Vo, KT | 1 |
| Horng, H | 1 |
| Smollin, CG | 1 |
| Benowitz, NL | 1 |
| Bueno, AM | 1 |
| Tena, B | 1 |
| Ubré, M | 1 |
| Gomar, C | 1 |
| Nogué-Xarau, S | 1 |
| Martínez-Morillo, E | 1 |
| Salgado-García, E | 1 |
| Butjosa-Roca, M | 1 |
| van Amsterdam, JG | 2 |
| Brunt, TM | 2 |
| McMaster, MT | 2 |
| Niesink, RJ | 1 |
| Niesink, R | 1 |
| van Noorden, MS | 1 |
| van den Brink, W | 1 |
| Gahlinger, PM | 1 |
| Capapé, S | 1 |
| Mora, E | 1 |
| Mintegui, S | 1 |
| García, S | 1 |
| Santiago, M | 1 |
| Benito, J | 1 |
| Licata, M | 1 |
| Pierini, G | 1 |
| Popoli, G | 1 |
| Green, SM | 1 |
| Clark, R | 1 |
| Hostetler, MA | 1 |
| Cohen, M | 1 |
| Carlson, D | 1 |
| Rothrock, SG | 1 |
| Stewart, CE | 1 |
| Gaulier, JM | 1 |
| Canal, M | 1 |
| Pradeille, JL | 1 |
| Marquet, P | 1 |
| Lachâtre, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Antipruritic Effect of Topical Ketamine, Amitriptyline, and Lidocaine[NCT03096444] | Phase 2 | 13 participants (Actual) | Interventional | 2017-05-23 | Terminated (stopped due to Efficacy was not seen after interim analysis) | ||
| ED Treatment of Suicidal Patients With Ketamine Infusion[NCT03502551] | Phase 2 | 0 participants (Actual) | Interventional | 2019-04-01 | Withdrawn (stopped due to Trial never received funding.) | ||
| A Prospective, Randomized, Double-Blind, Controlled Trial Evaluating the Efficacy of Ketamine for Improvement in Postoperative Pain Control After Spinal Fusion for Idiopathic Scoliosis[NCT02651324] | Phase 4 | 50 participants (Anticipated) | Interventional | 2013-05-31 | Active, not recruiting | ||
| Ketamine Frequency Treatment for Major Depressive Disorder[NCT00646087] | Phase 4 | 0 participants (Actual) | Interventional | 2008-03-31 | Withdrawn (stopped due to Pilot study determined that this study would not be feasible.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Peak itch intensity between the vehicle and 4 other active treatments (individual ketamine, amitriptyline, or lidocaine, and KeAmLi-combo). Itch intensity was measured on a 100mm scale visual analog scale for 10 minutes. 0 was weighted with no itch and 100 was weighted with most itch imaginable." (NCT03096444)
Timeframe: 10 minutes
| Intervention | Intensity score (Mean) |
|---|---|
| Topical KeAmLi Combo | 62.7 |
| Topical Ketamine | 63.1 |
| Topical Amitriptyline | 69.2 |
| Topical Lidocaine | 65.8 |
| Topical Vehicle | 61.9 |
Assess mechanical detection and pain thresholds using von Frey filaments stimulators (measured in force mN) to calculate the final threshold as the geometric mean of five series of ascending and descending stimuli. (NCT03096444)
Timeframe: 5 minutes
| Intervention | mN (Mean) | |
|---|---|---|
| Mechanical Detection Threshold | Mechanical Pain Threshold | |
| Topical Amitriptyline | 3.573423965 | 152.4768146 |
| Topical KeAmLi Combo | 3.519376956 | 152.3293608 |
| Topical Ketamine | 3.464204768 | 135.9 |
| Topical Lidocaine | 3.546037659 | 126.9 |
| Topical Vehicle | 3.525692637 | 148.7138273 |
Two standardized quantitative sensory tests are performed to measure warmth detection threshold (assesses the threshold of which warmth sensation is first detected) and heat pain threshold (assesses the threshold at which heat pain sensation is first detected). Measured in change in celsius. (NCT03096444)
Timeframe: 3 minutes
| Intervention | Degrees celsius (Mean) | |
|---|---|---|
| Warm Detection Threshold | Heat Pain Threshold | |
| Topical Amitriptyline | 33.9 | 40.0 |
| Topical KeAmLi Combo | 33.6 | 39.8 |
| Topical Ketamine | 34.0 | 40.0 |
| Topical Lidocaine | 33.7 | 39.4 |
| Topical Vehicle | 33.8 | 39.7 |
5 reviews available for ketamine and Drug Overdose
| Article | Year |
|---|---|
When to Pick the Nose: Out-of-Hospital and Emergency Department Intranasal Administration of Medications.
Topics: Administration, Intranasal; Analgesics, Opioid; Conscious Sedation; Dexmedetomidine; Drug Overdose; | 2017 |
Possible long-term effects of γ-hydroxybutyric acid (GHB) due to neurotoxicity and overdose.
Topics: Alcoholism; Anesthetics; Anesthetics, Dissociative; Animals; Central Nervous System Depressants; Cog | 2012 |
[Cognitive impairment due to intensive use and overdoses of gammahydroxybutyric acid (GHB)].
Topics: Cognition; Coma; Drug Overdose; Ethanol; Humans; Hydroxybutyrates; Illicit Drugs; Ketamine; Neurotox | 2012 |
Club drugs: MDMA, gamma-hydroxybutyrate (GHB), Rohypnol, and ketamine.
Topics: Anesthetics, Dissociative; Drug Overdose; Flunitrazepam; Hallucinogens; Humans; Ketamine; Leisure Ac | 2004 |
Ketamine as a street drug.
Topics: Adolescent; Anesthetics, Dissociative; Animals; Child; Drug Overdose; Emergency Treatment; Humans; I | 2001 |
18 other studies available for ketamine and Drug Overdose
| Article | Year |
|---|---|
[Identification of Three Arylcyclohexylamines (MXPr, MXiPr, and DMXE) in Illegal Products].
Topics: Drug Overdose; Humans; Japan; Ketamine | 2022 |
Treatment and outcome following substantial ketamine overdose in a dog.
Topics: Aggression; Animals; Dog Diseases; Dogs; Drug Overdose; Iatrogenic Disease; Ketamine; Male; Treatmen | 2023 |
Characteristics and circumstances of death related to the self-administration of ketamine.
Topics: Adolescent; Adult; Australia; Cause of Death; Drug Overdose; Female; Humans; Ketamine; Male; Middle | 2021 |
Ambient mass spectrometry for rapid diagnosis of psychoactive drugs overdose in an unstable patient.
Topics: 3,4-Methylenedioxyamphetamine; Adult; Consciousness Disorders; Drug Overdose; Emergency Service, Hos | 2018 |
Accidental Ketamine Overdose on Induction of General Anesthesia.
Topics: Aged; Anesthesia, General; Anesthetics, Dissociative; Delayed Emergence from Anesthesia; Drug Overdo | 2018 |
A Fatal Case Involving N-Ethyldeschloroketamine (2-Oxo-PCE) and Venlafaxine.
Topics: Drug Overdose; Fatal Outcome; Forensic Toxicology; Gas Chromatography-Mass Spectrometry; Humans; Ill | 2019 |
Massive Iatrogenic Pediatric Ketamine Overdose With Serial Levels and Minimal Morbidity.
Topics: Anesthetics, Dissociative; Child; Drug Overdose; Humans; Iatrogenic Disease; Ketamine; Morbidity | 2021 |
Detectability of Dissociative Psychoactive Substances in Urine by Five Commercial Phencyclidine Immunoassays.
Topics: Body Fluids; Cyclohexanones; Cyclohexylamines; Drug Overdose; Humans; Immunoassay; Ketamine; Phencyc | 2019 |
Compounded ointment results in severe toxicity in a pediatric patient.
Topics: Administration, Cutaneous; Amines; Analgesics; Body Surface Area; Bradycardia; Clonidine; Combined M | 2013 |
Ketamine use for acute agitation in the emergency department.
Topics: Adult; Aged; Aggression; Alcoholic Intoxication; Anesthetics, Dissociative; Antipsychotic Agents; Be | 2015 |
Pharmacological Investigations of the Dissociative 'Legal Highs' Diphenidine, Methoxphenidine and Analogues.
Topics: Acetamides; Analgesics, Opioid; Animals; Drug Overdose; Humans; Ketamine; Phencyclidine; Phenethylam | 2016 |
Severe Carisoprodol Withdrawal After a 14-Year Addiction and Acute Overdose.
Topics: Adult; Carisoprodol; Dexmedetomidine; Drug Overdose; Fentanyl; Haloperidol; Humans; Hypnotics and Se | 2017 |
[Incident involving the prescription of ketamine outside the operating room].
Topics: Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics; Anesthetics, Local; Carcinoma; Consc | 2009 |
[Life-threatening ketamine overdose].
Topics: Drug Overdose; Humans; Ketamine; Male; Severity of Illness Index; Young Adult | 2011 |
Prolonged sedation and airway complications after administration of an inadvertent ketamine overdose in emergency department.
Topics: Airway Obstruction; Anesthetics, Dissociative; Child, Preschool; Drug Overdose; Humans; Injections, | 2008 |
A fatal ketamine poisoning.
Topics: Adolescent; Chromatography, Gas; Drug Overdose; Gas Chromatography-Mass Spectrometry; Homicide; Huma | 1994 |
Inadvertent ketamine overdose in children: clinical manifestations and outcome.
Topics: Anesthetics, Dissociative; Child; Child, Preschool; Drug Overdose; Emergency Treatment; Female; Huma | 1999 |
[New drugs at "rave parties": ketamine and prolintane].
Topics: Adolescent; Adolescent Behavior; Anesthetics, Dissociative; Central Nervous System Stimulants; Costs | 2002 |