A group of disorders caused by defective salt reabsorption in the ascending LOOP OF HENLE. It is characterized by severe salt-wasting, HYPOKALEMIA; HYPERCALCIURIA; metabolic ALKALOSIS, and hyper-reninemic HYPERALDOSTERONISM without HYPERTENSION. There are several subtypes including ones due to mutations in the renal specific SODIUM-POTASSIUM-CHLORIDE SYMPORTERS.
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| "Ten children with Bartter's syndrome are described." | ( Dillon, MJ; Mitchell, MD; Shah, V, 1979) |
| "High renin in Bartter's syndrome is balanced by high PGE and kallikrein without hypertension." | ( Mills, IH, 1979) |
| "A new case of Bartter's syndrome is described." | ( François, R; Longin, B; Moreau, P; Sann, L; Sassard, J, 1975) |
| "Familial Bartter's syndrome is considered to be an autosomal recessive disease." | ( Higaki, J; Ogihara, T, 1992) |
| "II." | ( Proesmans, WC, 1992) |
| "Bartter's syndrome is associated with activation of prostaglandin metabolism." | ( Brown, RS; Cardi, M; Clive, DM; MacIntyre, DE; Salzman, EW; Stoff, JS, 1990) |
| "The treatment of Bartter's syndrome is fraught with difficulties, and there is no consensus concerning the pathogenetic mechanisms involved." | ( Christensen, P; Clementsen, P; Damkjaer, M; Giese, J; Hansen, CL; Høegholm, A, 1989) |
| "A case of maternal Bartter's syndrome is reported and prenatal management discussed." | ( Almeida, OD; Spinnato, JA, 1989) |
| "Bartter's syndrome is characterized by chronic hypokalaemia, activation of the renin-angiotensin system and normal blood pressure." | ( Jacobsen, JG; Jest, P; Kjaer, E; Klitgaard, NA; Pedersen, KE; Simonsen, E; Thomsen, N, 1989) |
| "A case of familial Bartter's syndrome is reported." | ( Favre, L; Girardin, E; Paunier, L; Vallotton, MB, 1986) |
| "Bartter's syndrome is generally attributed to a primary defect in salt reabsorption either in the ascending limb of Henle's loop or in the proximal tubule." | ( Alveranga, D; Carroll, HJ; Del Monte, ML; Kukar, NM; Oh, MS; Uribarri, J, 1985) |
| "Bartter's syndrome is a state associated with hyperprostaglandinemia and high urinary excretion of prostaglandin derivatives." | ( Lapointe, N; O'Regan, S; Samson, J, 1981) |
| "The Bartter syndrome is regarded as an autosomal recessive trait because of sib occurrence, equal sex ratio, and normal parents." | ( Rodrigues Pereira, R; van Wersch, J, 1983) |
| "Bartter's syndrome is characterised by constant simultaneous increase of plasma and urinary PGE2; this hypersecretion is insufficiently suppressed by indomethacin treatment." | ( Hornych, A, 1980) |
| "Bartter's syndrome is associated with an abnormality of erythrocyte membrane sodium and potassium transport." | ( Astley, P; Bobinski, H; Goldby, FS; Mallick, NP; Solomon, LR, 1982) |
| "The occurrence of Bartter's syndrome is described in a 74-year-old woman with a fractured hip." | ( Gordon, M; Pollard, A, 1980) |
| "Bartter's Syndrome is characterized by renal potassium wasting with hypokalemia, metabolic alkalosis, increased renin-angiotensin-aldosterone system, normal blood pressure, resistance to the pressor effects of angiotensin II and juxtaglomerular cell hyperplasia." | ( Choi, KC; Chung, YJ; Kang, YJ; Kim, NH; Kim, SW; Lee, JJ; Park, JW; Yeum, CH; Yoo, KS, 1995) |
| "Bartter's syndrome is an autosomal recessive disease characterized by diverse abnormalities in electrolyte homeostasis including hypokalaemic metabolic alkalosis; Gitelman's syndrome represents the predominant subset of Bartter's patients having hypomagnesemia and hypocalciuria." | ( Bia, MJ; Cushner, HM; Ellison, D; Gainza, FJ; Gitleman, HJ; Iwata, F; Karet, FE; Koolen, M; Lifton, RP; Molina, AM; Nelson-Williams, C; Simon, DB; Vaara, I, 1996) |
| "Bartter's syndrome is a rare autosomal recessive disorder characterized by hypokalemia, hyperaldosteronism, sodium wasting, normal blood pressure, hypochloremic alkalosis, and hyperplasia of the juxtaglomerular apparatus." | ( Graves, W; Monga, M; O'Sullivan, E, 1997) |
| "Antenatal Bartter syndrome is a variant of inherited renal-tubular disorders associated with hypokalemic alkalosis." | ( Antignac, C; Brandis, M; Deschênes, G; Feldmann, D; Guay-Woodford, LM; Hebert, SC; Hildebrandt, F; Karolyi, L; Kelly, L; Knoers, NV; Konrad, M; Lemmink, HH; Seyberth, HW; Tebourbi, L; van den Heuvel, LP; Vargas-Poussou, R; Vollmer, M, 1998) |
| "Bartter syndrome is characterized by hyperplasia of the renal juxtaglomerular apparatus, hyperaldosteronism, and hypokalemic alkalosis." | ( Castagna, G; Marchini, G; Parolini, B; Tosi, R; Zarbin, M, 1998) |
| "Bartter's syndrome is a rare disease, but should be considered in the differential diagnosis of other disorders with growth failure and/or hypokalemia." | ( Abdel-al, YK; al-Ghanim, MM; al-Khuffash, FA; al-Najidi, AK; Badawi, MH; Habib, YQ; Yaeesh, SA, 1999) |
| "Bartter syndrome is characterized by renal potassium and chloride loss, hypokalaemia, hypochloraemic metabolic alkalosis and increased plasma renin activity along with elevated angiotensin II and hyperaldosteronism." | ( Kajiura, S; Matsushita, Y; Okajima, K; Oya, N; Suzuki, Y; Suzumori, K; Uemura, O, 1999) |
| "Bartter's syndrome is a rare renal tubular disorder, involving juxtaglomerular cells hyperplasia, characterized by normotensive hyper-reninism and secondary hyperaldosteronism, marked renal loss of potassium and profound hypokalaemia." | ( Li, IC; To, WW, 2000) |
| "Bartter's syndrome is caused by dysfunction of thick ascending limb cells." | ( Ellison, DH, 2000) |
| "Bartter's syndrome is a renal tubular disorder characterized by hypokalemia, metabolic alkalosis, increased urinary excretion of potassium and prostaglandins, a relative vascular resistance to the pressor effects of exogenous angiotensin II, and hyperplasia of the juxtaglomerular apparatus." | ( Han, JY; Kim, GA; Kim, JY; Kim, MJ; Lee, JS; Lee, SW; Song, JH, 2000) |
| "Renal salt loss in Bartter's syndrome is caused by impaired transepithelial transport in the loop of Henle." | ( Birkenhäger, R; Boettger, T; Estévez, R; Hildebrandt, F; Jentsch, TJ; Otto, E; Stein, V, 2001) |
| "A case of neonatal Bartter syndrome is reported." | ( Bavdekar, SB; Kabde, U; Kantharia, VC; Muranjan, MN; Parmar, RC, 2002) |
| "Primary Bartter syndrome is associated with endogenous increased levels of prostaglandins." | ( Allegaert, K; Devlieger, H; Gewillig, M; Proesmans, W; Vanhaesebrouck, S; Vanhole, C, 2003) |
| "Bartter's syndrome is characterized by hypochloremia, hypokalemia, metabolic alkalosis associated with renal potassium leakage, and normal blood pressure despite increased plasma renin activity." | ( Ertekin, V; Orbak, Z; Selimoglu, AM, 2003) |
| "Bartter's syndrome is a rare condition during pregnancy." | ( Courouble, N; Deruelle, P; Dufour, P; Magnenant, E; Puech, F, 2004) |
| "When Bartter's syndrome is associated with pregnancy, the management must be careful." | ( Courouble, N; Deruelle, P; Dufour, P; Magnenant, E; Puech, F, 2004) |
| "Bartter's syndrome is a disorder that has been linked to mutations in one of three ion transporter proteins: NKCC2 (type I), ROMK (type II) and CCLNKB (type III), which affects a final common pathway that participates in ion transport by thick ascending limb cells." | ( Amaral, TN; Gontijo, JA; Menegon, LF, 2004) |
| "Type II Bartter's syndrome is a hereditary hypokalemic renal salt-wasting disorder caused by mutations in the ROMK channel (Kir1." | ( Amorim, JB; Bailey, MA; Cantone, A; Giebisch, G; Hebert, SC; Leng, Q; MacGregor, GG; Malnic, G; Wang, T; Yan, Q, 2006) |
| "Bartter syndrome is an inherited renal tubular disorder with hypokalemia, hypochloremic metabolic alkalosis, normal blood pressure with hyper-reninemia and increased urinary loss of sodium, potassium and chloride." | ( Deenadayalan, M; Janakiraman, L; Kumar, PS; Vijayakumar, M, 2006) |
| "Neonatal Bartter syndrome is a rare condition, usually revealed by alkalosis and hypokalemia." | ( André, JL; Feldmann, M; Hamon, I; Hascoët, JM; Vieux, R, 2009) |
| "Bartter syndrome is traditionally treated with large doses of oral potassium with or without suppression of the renin-angiotensin system." | ( Bell, DS, 2009) |
| "Bartter's syndrome is a constellation of symptoms characterized by hyper-reninemic hypokalemia, metabolic alkalosis, elevated renin and aldosterone, low or normal blood pressure, and hyperplasia of the juxtaglomerular apparatus." | ( Chen, YH; Jeansonne, BG; Lin, JJ; Lu, Q; Tatum, R, 2009) |
| "Bartter syndrome is a group of rare autosomal-recessive disorders caused by a defect in distal tubule transport of sodium and chloride." | ( da Silva, JE; Mendes, L; Mendes, P; Vieira, H, 2012) |
| "The Bartter syndrome is a rare hereditary salt-wasting tubulopathy, characterized by metabolic alkalosis, hypokalemia, hyperreninemia and hyperaldosteronemia of varying severity." | ( Castro, I; Mendonça, M; Pinheiro, A, 2011) |
| "Bartter syndrome is a group of inherited, salt-losing tubulopathies presenting as hypokalemic metabolic alkalosis with normotensive hyperreninemia and hyperaldosteronism." | ( Aggarwal, VK; Ankur, K; Cheong, H; Khilnani, P; Saikia, B; Sharma, PK; Sharma, R, 2014) |
| "Antenatal Bartter syndrome is characterized by severe polyhydramnios in mother leading to premature delivery." | ( Afzal, M; Anwar, V; Azam, S; Khan, EA; Khan, WA; Rafiq, S; Yaqoob, A, 2014) |
| "Bartter syndrome is an autosomal recessive renal tubulopathy that presents with hypokalemic, hypochloremic metabolic alkalosis associated with increased urinary loss of sodium, potassium, calcium and chloride." | ( Al-Muhaizae, M; Hussain, S; Tarar, SH, 2015) |
| "Bartter syndrome is a severe inherited tubulopathy characterized by postnatal salt wasting, severe polyuria, dehydration, failure to thrive and secondary hyperaldosteronism." | ( Chevenne, D; Czerkiewicz, I; Deschênes, G; Dreux, S; Muller, F; Oury, JF; Pean de Ponfilly, G; Rachid, ML; Vargas-Poussou, R, 2016) |
| "Bartter syndrome is a rare heterogeneous group of autosomal-recessive salt-losing renal tubular disorders that can present in fetal life (antenatal Bartter syndrome; ABS) as "unexplained" early-onset polyhydramnios, often associated with growth restriction." | ( Kesby, G; Narayan, R; Peres, M, 2016) |
| "Bartter syndrome is a severe inherited tubulopathy characterized at birth by salt wasting, severe polyuria, dehydration, growth retardation and secondary hyperaldosteronism." | ( Chevenne, D; Czerkiewicz, I; Deschênes, G; Dreux, S; Muller, F; Oury, JF; Pean de Ponfilly, G; Rachid, M; Vargas-Poussou, R, 2017) |
| "Antenatal Bartter syndrome is a rare condition that can present with different clinical features." | ( Abdelgadir, IS; Elgharbawy, F; Juma, BE; Salameh, KM, 2017) |
| "Bartter syndrome is an autosomal recessive disorder caused by gene mutations that involve hypokalaemia, hypochloraemia and metabolic alkalosis along with raised serum renin, hyperaldosteronism and normal blood pressure." | ( Afzal, T; Fatima, S; Halim, A; Shirazi, IH, 2018) |
| "Bartter syndrome is an autosomal-recessive inherited disease in which patients present with hypokalemia and metabolic alkalosis." | ( Hu, S; Li, H; Li, J; Nie, Y; Tan, M; Wang, R; Zhu, S, 2019) |
| "Bartter syndrome is a rare hereditary salt-losing tubulopathy caused by mutations of several genes in the thick ascending limb of Henle's loop, characterized by polyuria, hypokalemic metabolic alkalosis, growth retardation and normal blood pressure." | ( Assadi, F; Mazaheri, M; Sadeghi-Bojd, S, 2020) |
| "Bartter's syndrome is a rare disorder usually presenting antenatal or in childhood and is characterized by hypokalemia, metabolic alkalosis, hyperaldosteronism and normal blood pressure." | ( Arif, MS; Yaqub, S, 2020) |
| "Bartter syndrome is a rare disorder characterized by reduced sodium chloride transport in the distal nephrons of the kidney." | ( Khan, FA; Raza, D, 2020) |
| "Bartter syndrome is an autosomal recessive disorder manifested by a defect in sodium-potassium-chloride transport in the thick ascending limb of Henle with different genetic origins and molecular pathophysiology." | ( Akther, M; Dey, SK; Jahan, I; Mannan, MA; Moni, SC; Shabuj, KH; Shahidullah, M, 2020) |
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| "A young patient with Bartter's syndrome was treated for three months with 100 mg/kg/day of aspirin to inhibit prostaglandin synthesis." | ( Flamenbaum, W; Lentz, R; Norby, L; Ramwell, P, 1976) |
| "Three patients suffering from Bartter's syndrome were studied before and after 5 days of treatment with the prostaglandin synthetase inhibitors, aspirin and indomethacin." | ( Aurell, M; Hansson, L; Rudin, A; Westberg, G, 1979) |
| "Six children with Bartter's syndrome aged 6 years 4 months to 13 years 11 months were treated with indomethacin (1." | ( David, M; Floret, D; Hage, GN; Roux, A; Teyssier, G, 1979) |
| "Two patients, one with Bartter's syndrome and one with severe abuse of diuretics, were investigated before and after indomethacin treatment." | ( Christensen, P; Hesse, B; Nielsen, I, 1979) |
| "This report concerns two patients with Bartter's syndrome who were treated with propranolol, spironolactone, and potassium supplements." | ( Berger, M; Brouhard, BH; Cunningham, RJ; Petrusick, T; Travis, LB, 1979) |
| "Two adults with Bartter's syndrome were treated first with propranolol and a potassium-sparing diuretic and then with indomethacin for 22 months." | ( Dray, F; Favre, L; Flory, ED; Glasson, P; Vallotton, MB, 1979) |
| "In three patients with Bartter's syndrome, indomethacin administration resulted in the disappearance of the hypokalemic alkalosis and in a normalization of the elevated plasma renin activity." | ( Bakker, K; Brentjens, JR; de Jong, PE; Donker, AJ; Doorenbos, H; van Eps, LW, 1977) |
| "It is suggested that patients with Bartter's syndrome be treated simultaneously with large doses of spironolactone and a high sodium intake." | ( Brown, RS; Solomon, RJ, 1975) |
| "Following a diagnosis of pseudo-Bartter's syndrome induced by long term intake of laxative and repeated diarrhea, the administration of laxative was interrupted and potassium, indomethacin and spironolactone were administered." | ( Isobe, H; Naitoh, S; Okano, K; Sasagawa, K; Sekita, N; Shimizu, M; Someya, K; Suzuki, S; Yamada, Y, 1990) |
| "The treatment of Bartter's syndrome is fraught with difficulties, and there is no consensus concerning the pathogenetic mechanisms involved." | ( Christensen, P; Clementsen, P; Damkjaer, M; Giese, J; Hansen, CL; Høegholm, A, 1989) |
| "In untreated Bartter's syndrome ICNa was significantly increased with NaERC and BMax significantly decreased compared to findings in controls and patients with other salt wasting disease." | ( Daman Willems, C; Dillon, MJ; Shah, V; Uchiyama, M, 1988) |
| "Seven patients with Bartter's syndrome were investigated before and after 3 months' treatment by enalapril." | ( Boer, P; Dorhout Mees, EJ; Hené, RJ; Koomans, HA; vd Stolpe, A; Verhoef, GE, 1987) |
| "In six patients with Bartter's syndrome, four with pseudo-Bartter's syndrome, and twenty with essential hypertension (EH) chronically treated with chlorthalidone, serum potassium (serum K+) and extracellular fluid volume (ECFV) were decreased, while plasma volume (PV) and blood volume (BV) were normal (see Table 1 for means, standard deviations, and levels of significance)." | ( Boer, P; Dorhout Mees, EJ; Geyskes, GG; Hené, RJ; Koomans, HA; Roos, JC; Van Shaik, BA, 1985) |
| "3 patients with Bartter's syndrome were studied under metabolic ward conditions before and during administration of captopril 25 mg t." | ( Aurell, M; Rudin, A, 1983) |
| "In two children with Bartter's syndrome, treatment with indomethacin halved the urinary excretion of prostaglandins E and F within 24 hours and subsequently maintained it within the normal range during follow-up for more than 5 years." | ( Hewitt, GJ; Mitchell, MD; Winterborn, MH, 1984) |
| "In 2 adult patients with Bartter's syndrome, in whom chloride reabsorption at the diluting segment of the nephron was markedly reduced, serum potassium concentration could be improved with oral administration of a large amount of potassium chloride." | ( Amagasaki, Y; Kato, E; Konishi, K; Nakata, I; Ozawa, Y; Saruta, T; Senba, S, 1984) |
| "Two patients with Bartter's syndrome were treated with indomethacin (2 mg/kg/day)." | ( Fennell, RS; Garin, EH; Iravani, A; Richard, GA, 1980) |
| "Patients with Bartter's syndrome treated with PG synthetase inhibitors for 1 week respond with a profound drop in renin, together with a rise in prorenin." | ( Balfe, JW; Chan, LL; Halperin, ML; Osmond, DH, 1981) |
| "Pseudo-Bartter's syndrome is characterised by normal urinary PGE2 excretion which is considerably decreased by indomethacin treatment at the same dose." | ( Hornych, A, 1980) |
| "In children with Bartter's syndrome, the increased urinary excretion of PGE, PGFalpha and potassium when the natriuresis was either decreased or increased after treatment." | ( Benzoni, D; Betend, B; Sassard, J; Vincent, M, 1981) |
| "African Americans with Bartter syndrome genotyped to date have homozygous deletion of ClC-Kb Clinical observations in our patients include partial correction of hypokalemia and suboptimal growth despite therapy." | ( Campos, A; Cruz, DN; Garin, EH; Perlman, SA; Schurman, SJ; Shoemaker, LR; Sutphen, R, 2001) |
| "We describe a case of iatrogenic pseudo-Bartter syndrome caused by administration of prostaglandin E1 (PGE1 alprostadil)." | ( Allegaert, K; Devlieger, H; Gewillig, M; Proesmans, W; Vanhaesebrouck, S; Vanhole, C, 2003) |
| "An 11-month-old child diagnosed with Bartter syndrome and failure to thrive was treated concurrently for elevated metal burden while he was undergoing standard medical interventions." | ( Crinnion, WJ; Tran, JQ, 2010) |
| "Infants with neonatal Bartter syndrome required rapid and enormous fluid and sodium supplementations or the early introduction of indomethacin treatment to achieve adequate weight gain during the early postnatal period." | ( Azzi, A; Chehade, H; Deschênes, G, 2015) |