Cervical Spondylosis

A form of spondylosis involving the INTERVERTEBRAL DISK, including both the annulus and the nucleus of the disk. It is usually the consequence of normal aging.

Synonym
Lumbarsacral Spondylosis
Cervical Spondylosis
Thoracic Spondylosis
Spondylosis Deformans
Spondylosis, Cervical

Excerpt	Reference
"Twenty-four consecutive patients with cervical spondylosis who were treated with cervical corpectomy and recombinant human bone morphogenetic protein-2 (rhBMP-2) with standalone anterior instrumentation were evaluated."	( Allert, J; Brothers, A; Emami, A; Hwang, K; Issa, K; Mont, MA; Pourtaheri, S, 2013)
"Fifty-eight patients with cervical spondylosis (CS) were treated with patented technology of ozone laser combined therapy using puncture needle between August 2008 and February 2010."	( Gu, K; Guo, Y; Li, Y; Liu, W; Wei, W; Yan, Y; Yu, L, 2017)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	22 (12.72)	23.3326
1990's	0 (0.00)	12.5806
2000's	16 (9.25)	18.1394
2010's	114 (65.90)	28.8240
2020's	21 (12.14)	9.53

Drug	Relationship Strength	Studies	Trials
gamma-aminobutyric acid	medium	1	1
choline	medium	3	2
creatine	medium	6	1
lactic acid	low	1	0
glycerol	medium	1	1
homogentisic acid	low	1	0
inositol	low	1	0
niacinamide	low	1	0
aspirin	low	2	0
bupivacaine	low	1	0
carisoprodol	low	1	0
diclofenac	low	1	0
ibuprofen	medium	1	1
lidocaine	medium	1	1
ketamine	low	1	0
mepivacaine	low	1	0
phenylbutazone	low	2	0
procaine	low	1	0
riluzole	medium	4	1
sodium fluoride	medium	1	1
tranexamic acid	low	1	0
zonisamide	low	1	0
prednisolone	low	3	0
prednisone	low	1	0
aspartic acid	medium	8	2
methylprednisolone	low	1	0
betamethasone	medium	1	1
muscone	low	1	0
gentian violet	low	1	0
durapatite	medium	11	1
vancomycin	low	1	0
tantalum	low	1	0
titanium	medium	39	3
gadolinium	low	6	0
tricalcium phosphate	low	4	0
calcium sulfate	medium	1	1
ozone	medium	2	1
trolamine salicylate	low	16	0
triamcinolone	low	1	0
substance p	low	2	0
fomesafen	low	1	0
adenosine	low	1	0
trazodone hydrochloride	low	1	0
n-acetylaspartic acid	medium	8	2
fluorodeoxyglucose f18	low	2	0
ropivacaine	low	1	0
glucosamine	medium	1	1
nitinol	low	1	0
17-ketosteroids	low	1	0
osteoprotegerin	low	1	0
dinoprostone	low	2	0
alprostadil	medium	3	2
hydromorphone	low	1	0
morphine	medium	2	1
latanoprost	low	1	0
sulfur	low	1	0
pregabalin	medium	2	2
carbocyanines	low	1	0
25-hydroxyvitamin d 2	low	2	0
limaprost	medium	3	2
gadolinium dtpa	medium	3	1
neuropeptide y	medium	1	1
sodium ethylxanthate	low	4	0
mobic	low	2	0
transforming growth factor beta	low	8	0
vitamin b 12	low	2	0
technetium tc 99m medronate	low	1	0
acyclovir	low	1	0
6-hydroxymethyl-7,8-dihydropterin	low	1	0

Protein Targets (716)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain E, Purine nucleoside phosphorylase	0	1	0	1
Chain A, HADH2 protein	7	0	0	7
Chain B, HADH2 protein	7	0	0	7
Chain A, ATP-DEPENDENT DNA HELICASE Q1	2	0	0	2
Chain A, Ferritin light chain	5	0	0	5
Thymidine kinase	0	1	0	1
thioredoxin reductase	9	0	0	9
phosphopantetheinyl transferase	4	0	0	4
GLS protein	6	0	0	6
TDP1 protein	11	0	0	11
Smad3	2	0	0	2
thyroid stimulating hormone receptor	7	0	0	7
EWS/FLI fusion protein	7	0	0	7
arylsulfatase A	7	0	0	7
euchromatic histone-lysine N-methyltransferase 2	14	0	0	14
activating transcription factor 6	5	0	0	5
Histone H2A.x	6	0	0	6
Bloom syndrome protein isoform 1	8	0	0	8
hemoglobin subunit beta	1	0	0	1
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	3	0	0	3
lamin isoform A-delta10	16	0	0	16
Solute carrier family 22 member 1	0	2	0	7
ATP-binding cassette sub-family C member 3	0	15	0	15
Multidrug resistance-associated protein 4	0	15	0	17
Solute carrier family 22 member 6	0	2	0	3
Bile salt export pump	0	2	0	2
Bile salt export pump	0	21	0	21
Purine nucleoside phosphorylase	0	2	0	2
Thymidine kinase, cytosolic	0	0	0	1
POU domain, class 2, transcription factor 2	0	0	0	1
Cytochrome P450 2C9	0	8	0	9
Cytochrome P450 2J2	0	5	0	5
Disintegrin and metalloproteinase domain-containing protein 17	3	0	0	3
Purine nucleoside phosphorylase	0	0	1	1
Solute carrier family 22 member 6	0	2	0	4
Thymidine kinase	0	1	0	1
Solute carrier family 22 member 8	0	2	0	4
Canalicular multispecific organic anion transporter 1	0	13	0	13
Thymidine kinase	0	1	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	10	0	0	10
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Structure of PAE2307 in complex with adenosine	0	0	1	1
Chain B, Structure of PAE2307 in complex with adenosine	0	0	1	1
Chain A, ADENOSINE RECEPTOR A2A	0	1	0	1
Chain A, ADENOSINE RECEPTOR A2A	0	1	0	1
Chain A, tRNA (guanine-N(1)-)-methyltransferase	0	0	1	1
Chain A, Uncharacterized protein MJ0883	0	0	1	1
AR protein	19	0	0	19
signal transducer and activator of transcription 6, interleukin-4 induced	1	0	0	1
regulator of G-protein signaling 4	5	0	0	5
glucocorticoid receptor [Homo sapiens]	15	0	0	15
retinoid X nuclear receptor alpha	10	0	0	10
estrogen nuclear receptor alpha	21	0	0	21
NPYLR7B	0	0	1	1
IDH1	7	0	0	7
glycogen synthase kinase-3 beta isoform 1	0	0	1	1
mitogen-activated protein kinase 1	6	0	0	6
flap endonuclease 1	4	0	0	4
nuclear receptor ROR-gamma isoform 1	4	0	0	4
peripheral myelin protein 22	5	0	0	5
survival motor neuron protein isoform d	4	0	0	4
high affinity choline transporter 1 isoform a	0	1	0	1
Sodium/nucleoside cotransporter 1	0	2	0	2
Calcium dependent protein kinase	0	1	0	1
Mitogen-activated protein kinase kinase kinase 7	0	0	1	1
Sodium/nucleoside cotransporter 2	0	2	0	2
Voltage-dependent calcium channel gamma-2 subunit	6	0	0	6
Rap guanine nucleotide exchange factor 3	3	0	0	3
Epidermal growth factor receptor	0	4	0	4
Phosphoglycerate kinase 1	0	1	0	1
Adenosine deaminase	0	0	0	1
Avidin	0	0	1	1
Adenosine deaminase	0	0	0	1
Glyceraldehyde-3-phosphate dehydrogenase	0	2	0	2
Receptor tyrosine-protein kinase erbB-2	0	1	0	1
Insulin receptor	0	0	0	1
Phosphoglycerate kinase 2	0	1	0	1
Heat shock protein HSP 90-alpha	0	1	1	2
Platelet-derived growth factor receptor beta	0	0	0	1
Adenosine receptor A3	0	4	2	7
Heat shock 70 kDa protein 1A	0	1	0	1
Heat shock cognate 71 kDa protein	0	0	1	1
Fibroblast growth factor receptor 1	0	0	0	1
Inosine-5'-monophosphate dehydrogenase 2	0	1	0	1
Endoplasmin	0	1	1	2
Glutamate receptor 2	6	0	0	6
Inosine-5'-monophosphate dehydrogenase 1	0	1	0	1
Fibroblast growth factor receptor 2	0	0	0	1
Fibroblast growth factor receptor 4	0	0	0	1
Fibroblast growth factor receptor 3	0	0	0	1
Streptavidin	0	0	1	1
Adenosylhomocysteinase	0	0	0	1
Adenosine receptor A1	0	3	1	4
Adenosine receptor A3	0	1	0	1
Adenosine receptor A2a	0	3	2	6
Adenosine receptor A2b	0	0	1	2
Adenosine receptor A2b	0	1	1	2
Adenylate kinase 2, mitochondrial	0	1	0	1
Adenosine receptor A1	0	2	2	5
Adenosine receptor A2a	0	3	1	4
Adenylate kinase isoenzyme 1	0	1	0	1
Phosphatidylinositol 4-kinase alpha	0	2	0	3
Adenosine receptor A1	0	0	1	1
Adenosine kinase	0	0	0	1
Adenosine deaminase	0	0	0	1
Equilibrative nucleoside transporter 2	0	2	0	2
Phosphatidylinositol 4-kinase type 2-beta	0	2	0	3
Histone-lysine N-methyltransferase, H3 lysine-79 specific	0	1	0	1
Equilibrative nucleoside transporter 1	0	2	0	2
Phosphatidylinositol 4-kinase type 2-alpha	0	2	0	3
Solute carrier family 28 member 3	0	2	0	2
Adenosine kinase	0	1	0	2
Phosphatidylinositol 4-kinase beta	0	2	0	3
5-methylthioadenosine/S-adenosylhomocysteine deaminase	0	0	0	1
Adenosine transporter 1	0	0	0	1
peroxisome proliferator activated receptor gamma	7	0	0	7
Cellular tumor antigen p53	11	0	0	11
Thromboxane-A synthase	0	1	0	1
Prostaglandin E2 receptor EP3 subtype	0	2	0	2
Prostaglandin E2 receptor EP4 subtype	0	2	1	3
Prostaglandin E2 receptor EP1 subtype	0	2	0	2
Prostacyclin receptor	0	3	2	5
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Solute carrier organic anion transporter family member 2A1	0	0	0	2
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Prostaglandin E2 receptor EP2 subtype	0	2	1	3
Solute carrier organic anion transporter family member 2A1	0	1	0	3
Solute carrier organic anion transporter family member 2B1	0	1	0	1
Solute carrier organic anion transporter family member 3A1	0	0	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	6	0	0	6
aldehyde dehydrogenase 1 family, member A1	7	0	0	7
cytochrome P450 2C19 precursor	1	0	0	1
lethal factor (plasmid)	3	0	0	3
Metabotropic glutamate receptor 6	0	0	1	1
Excitatory amino acid transporter 4	0	1	0	1
Glutamate transporter homolog	0	0	1	1
Carbonic anhydrase 1	0	7	0	9
Carbonic anhydrase 2	0	7	1	10
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	0	1	0	1
5-hydroxytryptamine receptor 1D	0	0	0	1
Glutamate receptor ionotropic, NMDA 1	0	3	0	3
Excitatory amino acid transporter 1	0	1	0	1
Excitatory amino acid transporter 2	0	1	0	1
Excitatory amino acid transporter 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	3	0	3
Glutamate receptor ionotropic, NMDA 2B	0	3	0	3
Glutamate receptor ionotropic, NMDA 2C	0	3	0	3
Metabotropic glutamate receptor 1	0	0	1	1
Metabotropic glutamate receptor 2	0	0	1	1
Carbonic anhydrase-like protein, putative	0	0	0	1
Glutamate receptor ionotropic, NMDA 2D	0	3	0	3
Glutamate receptor ionotropic, NMDA 3B	0	3	0	3
Carbonic anhydrase 4	0	1	0	2
Glutamate receptor ionotropic, NMDA 3A	0	3	0	3
Chain A, Phospholipase A2 isoform 3	0	0	1	1
Chain A, 2-oxoglutarate Oxygenase	4	0	0	4
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
interleukin 8	1	0	0	1
hypothetical protein, conserved	2	0	0	2
cytochrome P450 family 3 subfamily A polypeptide 4	10	0	0	10
retinoic acid nuclear receptor alpha variant 1	12	0	0	12
estrogen-related nuclear receptor alpha	17	0	0	17
cytochrome P450 2D6	5	0	0	5
glucocerebrosidase	2	0	0	2
peroxisome proliferator-activated receptor delta	5	0	0	5
Rac1 protein	0	0	1	1
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	4	0	0	4
DNA polymerase iota isoform a (long)	4	0	0	4
DNA polymerase kappa isoform 1	6	0	0	6
muscarinic acetylcholine receptor M1	5	0	0	5
Prostaglandin-H2 D-isomerase	0	1	0	1
Prostaglandin G/H synthase 1	0	3	0	3
Prostaglandin G/H synthase 2	0	2	0	2
Fatty acid-binding protein, liver	0	4	0	4
Integrin beta-3	3	1	0	4
Myeloperoxidase	0	1	0	1
Prostaglandin G/H synthase 1	0	5	0	5
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Integrin alpha-IIb	3	1	0	4
Glutathione hydrolase 1 proenzyme	0	1	0	1
Prostaglandin G/H synthase 1	0	5	0	5
Substance-P receptor	0	3	0	3
Prostaglandin G/H synthase 2	0	7	0	7
Urotensin-2 receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	2	0	2
Nuclear receptor ROR-gamma	3	0	0	3
Ras-related protein Rab-2A	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	6	3	1	10
Prostaglandin G/H synthase 2	0	4	0	4
Rho-associated protein kinase 2	0	1	0	1
Nicotinate phosphoribosyltransferase	0	2	0	2
Solute carrier family 22 member 20	0	4	0	4
Solute carrier family 22 member 6	0	4	0	4
Sigma non-opioid intracellular receptor 1	0	1	1	2
Sigma non-opioid intracellular receptor 1	0	0	1	1
pregnane X receptor	4	0	0	4
GLI family zinc finger 3	13	0	0	13
progesterone receptor	10	0	0	10
farnesoid X nuclear receptor	6	0	0	6
pregnane X nuclear receptor	14	0	0	14
vitamin D (1,25- dihydroxyvitamin D3) receptor	10	0	0	10
aryl hydrocarbon receptor	7	0	0	7
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	9	0	0	9
nuclear receptor subfamily 1, group I, member 2	4	0	0	4
thyroid hormone receptor beta isoform a	4	0	0	4
nuclear factor erythroid 2-related factor 2 isoform 2	6	0	0	6
galanin receptor type 3	0	1	0	1
nuclear factor erythroid 2-related factor 2 isoform 1	11	0	0	11
Glucocorticoid receptor	0	10	2	17
Glycine receptor subunit alpha-1	0	10	0	10
Glycine receptor subunit beta	0	10	0	10
Glycine receptor subunit alpha-2	0	10	0	10
Glycine receptor subunit alpha-3	0	10	0	10
ORF73	0	0	1	1
Potassium channel subfamily K member 3	0	4	0	4
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 2	0	1	2	3
Potassium channel subfamily K member 9	0	1	0	1
RAR-related orphan receptor gamma	10	0	0	10
USP1 protein, partial	5	0	0	5
NFKB1 protein, partial	4	0	0	4
chromobox protein homolog 1	8	0	0	8
ras-related protein Rab-9A	2	0	0	2
geminin	17	0	0	17
cytochrome P450 3A4 isoform 1	6	0	0	6
Gamma-aminobutyric acid receptor subunit pi	6	2	0	8
Gamma-aminobutyric acid receptor subunit beta-1	6	2	0	8
Gamma-aminobutyric acid receptor subunit delta	6	2	0	8
Gamma-aminobutyric acid receptor subunit gamma-2	6	2	1	9
Gamma-aminobutyric acid receptor subunit alpha-5	6	2	0	8
Gamma-aminobutyric acid receptor subunit alpha-3	6	2	0	8
Gamma-aminobutyric acid receptor subunit gamma-1	6	2	0	8
Gamma-aminobutyric acid receptor subunit alpha-2	6	2	0	8
Gamma-aminobutyric acid receptor subunit alpha-4	6	2	0	8
Gamma-aminobutyric acid receptor subunit gamma-3	6	2	0	8
Gamma-aminobutyric acid receptor subunit alpha-6	6	2	0	8
Gamma-aminobutyric acid receptor subunit beta-3	6	2	0	8
Gamma-aminobutyric acid receptor subunit beta-2	6	2	1	9
GABA theta subunit	6	2	0	8
Gamma-aminobutyric acid receptor subunit epsilon	6	2	0	8
ATP-dependent phosphofructokinase	5	0	0	5
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Putative Glycine Betaine-binding Abc Transporter Protein	0	0	1	1
Chain A, PUTATIVE GLYCINE BETAINE-BINDING ABC TRANSPORTER PROTEIN	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Choline-binding protein	0	0	1	1
Solute carrier family 22 member 1	0	1	0	2
Solute carrier family 22 member 2	0	0	0	2
Solute carrier family 22 member 2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-3	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	1	1	0	2
Neuronal acetylcholine receptor subunit alpha-2	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	1	1	0	2
Neuronal acetylcholine receptor subunit beta-3	0	1	0	1
Neuronal acetylcholine receptor subunit beta-4	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-5	0	1	0	1
Acetylcholinesterase	0	3	0	3
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Choline O-acetyltransferase	0	0	0	1
Neuronal acetylcholine receptor subunit alpha-6	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-9	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Solute carrier family 22 member 1	0	1	0	2
High affinity choline transporter 1	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-10	0	1	0	1
Solute carrier family 22 member 2	0	1	0	2
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Proton-coupled amino acid transporter 1	0	2	0	2
Aldo-keto reductase family 1 member B10	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	1	0	2
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Dihydrofolate reductase	0	3	0	3
Cytochrome c oxidase subunit 2	0	1	0	1
Transthyretin	0	0	1	3
Albumin	0	2	3	5
Cytochrome P450 3A4	0	4	2	6
Interleukin-8	0	1	0	1
Calcium/calmodulin-dependent protein kinase type II subunit alpha	0	1	0	1
Fatty acid-binding protein, intestinal	0	2	0	2
Aldo-keto reductase family 1 member B1	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	1	0	3
UDP-glucuronosyltransferase 1-6	0	2	0	2
UDP-glucuronosyltransferase 1A1	0	3	0	3
UDP-glucuronosyltransferase 1A4	0	1	0	1
Sodium- and chloride-dependent GABA transporter 1	0	2	0	2
C-X-C chemokine receptor type 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	2	0	2
Sodium- and chloride-dependent GABA transporter 3	0	2	0	2
Prostaglandin G/H synthase 2	0	3	0	4
UDP-glucuronosyltransferase 1A3	0	0	0	3
UDP-glucuronosyltransferase 2B10	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	2	0	2
Prostaglandin G/H synthase 2	0	3	0	3
Carbonic anhydrase 9	0	4	0	5
Prostaglandin G/H synthase 1	0	3	0	4
Multidrug and toxin extrusion protein 1	0	2	0	2
P2Y purinoceptor 12	0	1	0	1
UDP-glucuronosyltransferase 1A7	0	1	0	1
UDP-glucuronosyltransferase 1A10	0	1	0	1
Chain A, Cruzipain	2	0	0	2
SMAD family member 2	4	0	0	4
SMAD family member 3	4	0	0	4
thyroid stimulating hormone receptor	3	0	0	3
prostaglandin E2 receptor EP2 subtype	1	0	0	1
vitamin D3 receptor isoform VDRA	4	0	0	4
thyroid hormone receptor beta isoform 2	7	0	0	7
Solute carrier organic anion transporter family member 1A5	0	0	0	1
Prostaglandin E2 receptor EP1 subtype	0	2	1	3
Prostaglandin E2 receptor EP4 subtype	0	2	1	3
Prostaglandin F2-alpha receptor	0	0	1	1
Prostaglandin E2 receptor EP4 subtype	0	1	1	2
Prostaglandin E2 receptor EP3 subtype	0	2	1	3
Prostaglandin E2 receptor EP2 subtype	0	2	1	3
Solute carrier family 22 member 7	0	0	0	1
Prostaglandin E2 receptor EP2 subtype	0	1	1	2
Solute carrier family 22 member 7	0	0	0	1
Solute carrier family 22 member 11	0	0	0	1
Solute carrier organic anion transporter family member 1B2	0	0	0	1
Solute carrier family 22 member 7	0	0	0	1
Luciferase	7	0	0	7
hypoxia-inducible factor 1 alpha subunit	6	0	0	6
Gamma-aminobutyric acid	0	0	1	1
Gamma-aminobutyric acid receptor subunit rho-3	0	0	1	1
ATAD5 protein, partial	3	0	0	3
Hsf1 protein	0	0	1	1
bromodomain adjacent to zinc finger domain 2B	2	0	0	2
D(1A) dopamine receptor	2	0	0	2
transcriptional regulator ERG isoform 3	3	0	0	3
histone-lysine N-methyltransferase 2A isoform 2 precursor	1	0	0	1
histone acetyltransferase KAT2A isoform 1	3	0	0	3
neuropeptide S receptor isoform A	2	0	0	2
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Histone deacetylase 3	0	1	0	1
Gamma-aminobutyric acid type B receptor subunit 2	0	0	1	1
Gamma-aminobutyric acid type B receptor subunit 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-6	0	0	1	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	0	1	1
Gamma-aminobutyric acid receptor subunit delta	0	0	1	1
Gamma-aminobutyric acid receptor subunit rho-1	0	0	2	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit rho-2	0	0	1	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent taurine transporter	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	1	2
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-2	0	1	1	2
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-1	0	0	1	1
Histone deacetylase 4	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	0	1	1
Gamma-aminobutyric acid receptor subunit beta-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit epsilon	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
TAR DNA-binding protein 43	6	0	0	6
Histone deacetylase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	1	2
Sterol O-acyltransferase 1	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	0	0	1	1
Histone deacetylase 7	0	1	0	1
Histone deacetylase 2	0	1	0	1
Polyamine deacetylase HDAC10	0	1	0	1
Histone deacetylase 11	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Histone deacetylase 8	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	1	1
Platelet glycoprotein VI	0	0	1	1
Gamma-aminobutyric acid receptor subunit theta	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	0	1	1
Histone deacetylase 6	0	1	0	1
Gamma-aminobutyric acid type B receptor subunit 1	0	0	1	1
Histone deacetylase 9	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Histone deacetylase 5	0	1	0	1
Gamma-aminobutyric acid type B receptor subunit 1	0	1	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	1	0	0	1
acetylcholinesterase	3	0	0	3
beta-amyloid peptide, A beta {N-terminal} [human, cerebrospinal fluid, conditioned medium of mixed-brain cell cultures, Peptide Partial, 33 aa]	1	0	0	1
Microtubule-associated protein tau	4	0	0	5
caspase 7, apoptosis-related cysteine protease	1	0	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	4	0	0	4
alpha synuclein, partial	1	0	0	1
estrogen receptor 2 (ER beta)	5	0	0	5
nuclear receptor subfamily 1, group I, member 3	7	0	0	7
G	5	0	0	5
67.9K protein	4	0	0	4
luciferase	1	0	0	1
caspase-3	1	0	0	1
thyrotropin-releasing hormone receptor	1	0	0	1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	2	0	0	2
v-jun sarcoma virus 17 oncogene homolog (avian)	7	0	0	7
Caspase-7	3	0	0	3
cellular tumor antigen p53 isoform a	3	0	0	3
tumor necrosis factor	1	0	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
potassium voltage-gated channel subfamily H member 2 isoform d	3	0	0	3
caspase-3	3	0	0	3
histone deacetylase 9 isoform 3	2	0	0	2
heat shock protein beta-1	3	0	0	3
huntingtin isoform 2	1	0	0	1
nuclear factor NF-kappa-B p105 subunit isoform 1	1	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	1	0	0	1
Interferon beta	8	0	0	8
HLA class I histocompatibility antigen, B alpha chain	5	0	0	5
Tyrosine-protein kinase Fyn	0	1	0	1
Muscarinic acetylcholine receptor M2	0	2	0	2
Muscarinic acetylcholine receptor M4	0	2	0	2
Muscarinic acetylcholine receptor M5	0	2	0	2
Alpha-2A adrenergic receptor	0	3	1	4
60 kDa chaperonin	0	1	0	1
Cytochrome P450 2D6	0	2	0	2
60 kDa heat shock protein, mitochondrial	0	2	0	2
Muscarinic acetylcholine receptor M1	0	2	0	2
D(2) dopamine receptor	0	2	0	2
Androgen receptor	0	5	0	5
Alpha-1B adrenergic receptor	0	3	0	3
Alpha-2B adrenergic receptor	0	2	0	2
Alpha-2C adrenergic receptor	0	2	0	2
Muscarinic acetylcholine receptor M3	0	2	0	2
Substance-K receptor	0	4	0	4
D(1A) dopamine receptor	0	2	0	2
Glutamate receptor ionotropic, kainate 1	1	0	0	1
Histamine H2 receptor	0	2	0	2
Alpha-1D adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 2A	0	2	0	2
Mu-type opioid receptor	0	5	2	8
D(3) dopamine receptor	0	2	0	2
Kappa-type opioid receptor	0	5	2	8
Glutamate receptor ionotropic, kainate 2	1	0	0	1
Glutamate receptor ionotropic, kainate 3	1	0	0	1
Alpha-1A adrenergic receptor	0	3	0	3
Histamine H2 receptor	3	0	0	3
Spike glycoprotein	1	0	0	1
10 kDa heat shock protein, mitochondrial	0	2	0	2
Fatty-acid amide hydrolase 1	1	2	0	3
Inositol monophosphatase 1	1	0	0	1
Glutamate receptor ionotropic, kainate 4	1	0	0	1
Sodium-dependent dopamine transporter	0	2	0	2
Leukotriene B4 receptor 1	1	0	0	1
Thiosulfate sulfurtransferase	0	2	0	2
60 kDa chaperonin	0	2	0	2
Glutamate receptor ionotropic, kainate 5	1	0	0	1
10 kDa chaperonin	0	2	0	2
Inositol hexakisphosphate kinase 1	5	0	0	5
ATPase family AAA domain-containing protein 5	7	0	0	7
Ataxin-2	7	0	0	7
Leukotriene B4 receptor 2	1	0	0	1
cytochrome P450 2C9, partial	5	0	0	5
Chain B, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E	0	0	1	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Solute carrier family 22 member 3	0	0	0	1
Delta-type opioid receptor	0	3	1	5
nonstructural protein 1	4	0	0	4
importin subunit beta-1 isoform 1	1	0	0	1
snurportin-1	1	0	0	1
muscleblind-like protein 1 isoform 1	4	0	0	4
Acid-sensing ion channel 3	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	1	0	1
Albumin	0	1	0	1
Albumin	0	0	1	1
Cholinesterase	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	2
Prostaglandin G/H synthase 1	0	1	0	1
Caspase-1	0	1	0	1
Aldo-keto reductase family 1 member C3	0	1	0	1
Caspase-3	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	1	0	1
Caspase-4	0	1	0	1
Caspase-5	0	1	0	1
Caspase-9	0	1	0	1
Acid-sensing ion channel 1	0	1	0	1
Mu-type opioid receptor	0	4	0	4
Dehydrogenase/reductase SDR family member 9	0	1	0	1
Chain B, Pulmonary surfactant-associated protein D	0	1	0	1
Chain A, Pulmonary surfactant-associated protein D	0	1	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	2	0	0	2
Amyloid-beta precursor protein	0	1	0	1
Sodium/myo-inositol cotransporter 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Acetylcholinesterase	0	2	0	2
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Sodium channel protein type 4 subunit alpha	0	2	0	2
Cholinesterase	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	2	0	2
Glutamate receptor ionotropic, NMDA 2A	0	2	0	2
Glutamate receptor ionotropic, NMDA 2B	0	2	0	2
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Chain A, Beta-lactamase	3	0	0	3
beta-2 adrenergic receptor	1	0	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	2	0	2
Sodium channel protein type 3 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	4	0	4
Sodium channel protein type 5 subunit alpha	0	1	0	1
Sodium channel protein type 9 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily D member 2	0	1	0	1
Potassium channel subfamily K member 18	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
PPM1D protein	1	0	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	1	0	0	1
alpha-galactosidase	1	0	0	1
Glutathione reductase, mitochondrial	0	1	0	1
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Opioid receptor, delta 1b	0	1	0	1
Opioid receptor homologue	0	1	0	1
ATP-dependent translocase ABCB1	0	1	0	1
Acyl-CoA desaturase 1	0	1	0	1
ATP-dependent translocase ABCB1	0	1	0	1
Muscarinic acetylcholine receptor M1	0	1	0	1
Muscarinic acetylcholine receptor M3	0	1	0	1
Muscarinic acetylcholine receptor M4	0	1	0	1
Muscarinic acetylcholine receptor M5	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
Translocator protein	0	1	1	2
Histidine decarboxylase	0	0	1	1
ATP-dependent translocase ABCB1	0	1	0	1
Proteinase-activated receptor 1	0	1	1	2
Sodium-dependent serotonin transporter	0	2	0	2
Delta-type opioid receptor	0	2	0	3
Delta-type opioid receptor	0	3	1	5
Kappa-type opioid receptor	0	2	1	4
Mu-type opioid receptor	0	4	1	8
Kappa-type opioid receptor	0	2	1	4
Kappa-type opioid receptor	0	2	0	2
Mu-type opioid receptor	0	2	1	5
Nociceptin receptor	0	1	0	1
5-hydroxytryptamine receptor 7	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Beta-2 adrenergic receptor	0	1	0	1
Mas-related G-protein coupled receptor member X2	0	0	2	2
Mu-type opioid receptor	0	1	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	1	0	0	1
Rap guanine nucleotide exchange factor 4	1	0	0	1
Neuropeptide Y receptor type 1	0	2	0	2
Neuropeptide Y receptor type 2	0	2	0	2
Chain A, NAD-dependent deacetylase	0	1	0	1
Poly [ADP-ribose] polymerase 2	0	1	0	1
NAD-dependent histone deacetylase SIR2	0	1	0	1
Coagulation factor VII	0	1	0	1
Poly [ADP-ribose] polymerase 1	0	1	0	1
Tissue factor	0	1	0	1
Cytochrome P450 3A5	0	1	0	1
NAD-dependent protein deacetylase HST2	0	1	0	1
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
NAD(+) hydrolase SARM1	0	1	0	1
NAD-dependent protein deacetylase sirtuin-2	0	1	0	1
NAD-dependent protein deacetylase sirtuin-6	0	1	0	1
NAD-dependent protein deacetylase sirtuin-1	0	1	0	1
NAD-dependent protein deacetylase sirtuin-3, mitochondrial	0	1	0	1
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
NAD-dependent protein deacetylase	0	1	0	1
Estrogen receptor 1	0	1	0	1
Parkin	2	0	0	2
cytochrome P450 2C9 precursor	2	0	0	2
fMet-Leu-Phe receptor	0	1	0	1
M-phase phosphoprotein 8	1	0	0	1
Cyclooxygenase-2	0	1	0	1
luciferase	0	0	0	1
Estrogen receptor	0	2	0	2
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	0	2	1	3
Androgen receptor	0	2	0	2
Glutamine synthetase	0	0	1	1
Histamine H1 receptor	0	0	1	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	0	2
thioredoxin glutathione reductase	2	0	0	2
Sodium-dependent noradrenaline transporter	0	4	0	4
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	2
Voltage-dependent calcium channel subunit alpha-2/delta-2	0	1	0	1
cytochrome P450 2D6 isoform 1	1	0	0	1
15-lipoxygenase, partial	1	0	0	1
pyruvate kinase	1	0	0	1
lysosomal alpha-glucosidase preproprotein	1	0	0	1
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
peripheral myelin protein 22 isoform 1	2	0	0	2
mu-type opioid receptor isoform MOR-1	0	0	1	1
urokinase-type plasminogen activator precursor	1	0	0	1
plasminogen precursor	1	0	0	1
urokinase plasminogen activator surface receptor precursor	1	0	0	1
5-hydroxytryptamine receptor 2A	0	0	1	1
pyruvate kinase PKM isoform b	1	0	0	1
Cytochrome P450 1A2	0	1	0	1
Aldo-keto reductase family 1 member B1	0	2	0	2
Ornithine decarboxylase	1	0	0	1
Cytochrome P450 2C19	0	1	0	1
Alpha-synuclein	1	0	0	1
Pteridine reductase 1	0	2	0	2
Carbonic anhydrase	0	2	0	2
Eyes absent homolog 2	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Substance-P receptor	0	2	0	2
Neuromedin-K receptor	0	0	1	1
Substance-K receptor	0	1	1	2
Substance-P receptor	0	2	1	3
Neuromedin-K receptor	0	1	1	2
Substance-K receptor	0	1	0	1
D(2) dopamine receptor	0	1	1	2
Substance-K receptor	0	1	0	1
Growth hormone secretagogue receptor type 1	0	0	1	1
Chain A, PLASMINOGEN	0	0	1	1
Chain A, PLASMINOGEN	0	0	1	1
Plasminogen	0	2	1	3
Urokinase-type plasminogen activator	0	1	0	1
acid sphingomyelinase	1	0	0	1
HLA class I histocompatibility antigen, A alpha chain	0	0	1	1
glp-1 receptor, partial	1	0	0	1
procathepsin L isoform 1 preproprotein	0	1	0	1
Alpha-2B adrenergic receptor	0	1	0	1
Alpha-2C adrenergic receptor	0	1	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Alpha-1D adrenergic receptor	0	1	0	1
D-alanyl-D-alanine dipeptidase	0	1	0	1
Transporter	0	1	0	1
Fumarate hydratase	1	0	0	1
polyprotein	1	0	0	1
Butyrophilin subfamily 3 member A1	0	0	1	2
Carbonic anhydrase 12	0	3	0	4
Geranylgeranyl pyrophosphate synthase	0	2	0	3
72 kDa type IV collagenase	0	1	0	1
Farnesyl pyrophosphate synthase	0	2	0	2
Matrix metalloproteinase-9	0	1	0	1
Neutrophil collagenase	0	1	0	1
Farnesyl diphosphate synthase	0	1	0	1
Matrix metalloproteinase-14	0	1	0	1
Farnesyl pyrophosphate synthase	0	2	0	2
Geranylgeranyl pyrophosphate synthase	0	2	0	2
Farnesyl pyrophosphate synthase	0	1	0	1
H	0	1	0	1
Carbonic anhydrase 14	0	3	0	4
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Prolyl endopeptidase	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase 3	0	2	0	2
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
Carbonic anhydrase 4	0	2	0	3
Carbonic anhydrase 6	0	2	0	3
Sodium-dependent dopamine transporter	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	2	1	4
Carbonic anhydrase 7	0	2	0	3
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Beta-carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase, alpha family	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 3	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Delta carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Amine oxidase [flavin-containing]	0	1	0	1
Carbonic anhydrase 13	0	2	0	2
Carbonic anhydrase 15	0	1	0	1
Carbonic anhydrase 13	0	0	0	1
Carbonic anhydrase 5B, mitochondrial	0	2	0	3
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(5)

Research Excerpts

Treatment

Research

Studies (173)

Protein Targets (716)

Cervical Spondylosis

Synonyms(5)

Research Excerpts

Treatment

Research

Studies (173)

Drugs Studied (82)

Protein Targets (716)