ketamine has been researched along with Amnesia in 17 studies
Ketamine: A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.
ketamine : A member of the class of cyclohexanones in which one of the hydrogens at position 2 is substituted by a 2-chlorophenyl group, while the other is substituted by a methylamino group.
Amnesia: Pathologic partial or complete loss of the ability to recall past experiences (AMNESIA, RETROGRADE) or to form new memories (AMNESIA, ANTEROGRADE). This condition may be of organic or psychologic origin. Organic forms of amnesia are usually associated with dysfunction of the DIENCEPHALON or HIPPOCAMPUS. (From Adams et al., Principles of Neurology, 6th ed, pp426-7)
| Excerpt | Relevance | Reference |
|---|---|---|
| " In order to understand the effect of dopamine/glutamate interactions on learning and memory, we investigated the effects of intra medial prefrontal cortex (mPFC) injections of dopaminergic agents on ketamine-induced amnesia by using a one-trial passive avoidance task in mice." | 7.83 | The influence of dopaminergic system in medial prefrontal cortex on ketamine-induced amnesia in passive avoidance task in mice. ( Akbarabadi, A; Bakhtazad, A; Farahmandfar, M; Zarrindast, MR, 2016) |
| " The control group and the test groups were comparable with regard to biological data, duration of operation, applied dosage of local anaesthetics and actual anxiety before operation." | 6.68 | [Analgesia-sedation for maxillo-facial surgery with midazolam-pentazocine and miazolam-ketamine. Clinical double-blind study of anxiety, analgesia, sedation and amnesia]. ( Daubländer, M; Dick, W; Lipp, M; Sebastian, M, 1995) |
| " Low-dose intravenous ketamine as the primary anesthetic following premedication with fentanyl and midazolam, and in conjunction with nitrous oxide, appeared to produce less hypoxia, hypercarbia, and apnea than when methohexital was used." | 5.07 | A double-blind comparison of low-dose intravenous ketamine and methohexital in adults. ( Anderson, JA; Blankstein, KC, 1991) |
| " In order to understand the effect of dopamine/glutamate interactions on learning and memory, we investigated the effects of intra medial prefrontal cortex (mPFC) injections of dopaminergic agents on ketamine-induced amnesia by using a one-trial passive avoidance task in mice." | 3.83 | The influence of dopaminergic system in medial prefrontal cortex on ketamine-induced amnesia in passive avoidance task in mice. ( Akbarabadi, A; Bakhtazad, A; Farahmandfar, M; Zarrindast, MR, 2016) |
| " Physostigmine and aspartic acid, but not haloperidol, diminished ketamine amnesia, therefore ketamine impaired the interaction of cholinergic and glutamate/aspartatergic neurons of hippocampal areas." | 3.68 | [Pharmacological correction of ketamine-impaired spatial memory of rats]. ( Kovalev, GV; Kuleshova, IP; Sazhin, VA, 1990) |
| " The control group and the test groups were comparable with regard to biological data, duration of operation, applied dosage of local anaesthetics and actual anxiety before operation." | 2.68 | [Analgesia-sedation for maxillo-facial surgery with midazolam-pentazocine and miazolam-ketamine. Clinical double-blind study of anxiety, analgesia, sedation and amnesia]. ( Daubländer, M; Dick, W; Lipp, M; Sebastian, M, 1995) |
| " It also reviews the comparative pharmacokinetics, adverse effects, and dosing of ketamine, propofol, and ketofol as agents for procedural sedation and analgesia." | 2.48 | Ketamine, propofol, and ketofol use for pediatric sedation. ( Alletag, MJ; Auerbach, MA; Baum, CR, 2012) |
| "Levels of dissociation were also higher in ketamine users only on the night of drug use." | 1.34 | Perceptual organization in ketamine users: preliminary evidence of deficits on night of drug use but not 3 days later. ( Curran, HV; Millard, I; Morgan, CJ; Muetzelfeldt, L; Uhlhaas, PJ, 2007) |
| "As propofol has some amnesic properties, any instructions given to the patient postoperatively should be in writing." | 1.29 | [Recovery after anesthesia with Diprivan]. ( Nguyen, HN, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (23.53) | 18.7374 |
| 1990's | 4 (23.53) | 18.2507 |
| 2000's | 4 (23.53) | 29.6817 |
| 2010's | 5 (29.41) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Belenichev, I | 1 |
| Burlaka, B | 1 |
| Puzyrenko, A | 1 |
| Ryzhenko, O | 1 |
| Kurochkin, M | 1 |
| Yusuf, J | 1 |
| Ekwutosi Patricia, C | 1 |
| Adewale Ganiyu, B | 1 |
| Benneth, BA | 1 |
| Ezekiel Olugbenga, I | 1 |
| Farahmandfar, M | 2 |
| Akbarabadi, A | 2 |
| Bakhtazad, A | 2 |
| Zarrindast, MR | 2 |
| Liy-Salmeron, G | 1 |
| Meneses, A | 1 |
| Eckle, VS | 1 |
| Hucklenbruch, C | 1 |
| Todorovic, SM | 1 |
| Alletag, MJ | 1 |
| Auerbach, MA | 1 |
| Baum, CR | 1 |
| Morgan, CJ | 2 |
| Perry, EB | 1 |
| Cho, HS | 1 |
| Krystal, JH | 1 |
| D'Souza, DC | 1 |
| Uhlhaas, PJ | 1 |
| Millard, I | 1 |
| Muetzelfeldt, L | 1 |
| Curran, HV | 1 |
| Dich-Nielsen, J | 1 |
| Holasek, J | 1 |
| Lipp, M | 1 |
| Daubländer, M | 1 |
| Sebastian, M | 1 |
| Dick, W | 1 |
| Nguyen, HN | 1 |
| Figallo, EM | 1 |
| McKenzie, R | 1 |
| Tantisira, B | 1 |
| Wadhwa, RK | 1 |
| Sinchioco, CS | 1 |
| Blankstein, KC | 1 |
| Anderson, JA | 1 |
| Kovalev, GV | 1 |
| Sazhin, VA | 1 |
| Kuleshova, IP | 1 |
| Sprints, AM | 1 |
| Vasar, EE | 1 |
| Allikmets, LKh | 1 |
| Soosaar, AKh | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Does a Single Intravenous Dose of Ketamine Reduce the Need for Supplemental Opioids in Post-Cesarean Section Patients?[NCT00486902] | 188 participants (Actual) | Interventional | 2006-07-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Cumulative hydrocodone/acetaminophen for supplemental analgesia to treat breakthrough pain for 72 hours following cesarean delivery (NCT00486902)
Timeframe: 72 hours
| Intervention | tablets (Median) |
|---|---|
| Ketamine | 10 |
| Placebo | 9 |
Number of subject reporting disturbing dreams at 72 hours post cesarean delivery (NCT00486902)
Timeframe: 72 hours
| Intervention | participants (Number) |
|---|---|
| Ketamine | 0 |
| Placebo | 0 |
Request for oral hydrocodone/acetaminophen for pain not controlled by around the clock non-steroidal antiflammatory drugs in the first 24 hours following cesarean delivery. (NCT00486902)
Timeframe: 24 hours
| Intervention | participants (Number) |
|---|---|
| Ketamine | 64 |
| Placebo | 66 |
Numeric rating for pain score (0 to 10) reported at 2 weeks following cesarean delivery. Zero is no pain and 10 is worst pain imaginable. (NCT00486902)
Timeframe: 2 weeks
| Intervention | Scores on a scale (Median) |
|---|---|
| Ketamine | 2 |
| Placebo | 2.6 |
Number of subjects reporting nausea in first 24 hours following cesarean delivery (NCT00486902)
Timeframe: 24 hours
| Intervention | participants (Number) |
|---|---|
| Ketamine | 27 |
| Placebo | 30 |
Number of subjects that vomited in the first 24 hours following cesarean delivery (NCT00486902)
Timeframe: 24 hours
| Intervention | participants (Number) |
|---|---|
| Ketamine | 13 |
| Placebo | 13 |
Number of subjects with pruritus in the first 24 hours following cesarean delivery (NCT00486902)
Timeframe: 24 hours
| Intervention | participants (Number) |
|---|---|
| Ketamine | 12 |
| Placebo | 19 |
Numeric rating of pain scores (NRS) scale (0 to 10) at time of supplemental analgesia request. Zero is no pain and 10 is worst pain imaginable. (NCT00486902)
Timeframe: 24 hours
| Intervention | Scores on a scale (Median) |
|---|---|
| Ketamine | 3 |
| Placebo | 4 |
2 reviews available for ketamine and Amnesia
| Article | Year |
|---|---|
[What do we know about anesthetic mechanisms?: hypnosis, unresponsiveness to surgical incision and amnesia].
Topics: Amnesia; Anesthesia; Anesthetics; Anesthetics, Dissociative; Anesthetics, Inhalation; Anesthetics, I | 2009 |
Ketamine, propofol, and ketofol use for pediatric sedation.
Topics: Adolescent; Amnesia; Analgesia; Analgesics, Non-Narcotic; Anesthetics, Dissociative; Antiemetics; An | 2012 |
3 trials available for ketamine and Amnesia
| Article | Year |
|---|---|
Greater vulnerability to the amnestic effects of ketamine in males.
Topics: Adult; Amnesia; Behavior; Brief Psychiatric Rating Scale; Cognition; Double-Blind Method; Excitatory | 2006 |
[Analgesia-sedation for maxillo-facial surgery with midazolam-pentazocine and miazolam-ketamine. Clinical double-blind study of anxiety, analgesia, sedation and amnesia].
Topics: Adjuvants, Anesthesia; Adult; Ambulatory Surgical Procedures; Amnesia; Analgesia; Anesthesia; Anesth | 1995 |
A double-blind comparison of low-dose intravenous ketamine and methohexital in adults.
Topics: Adolescent; Adult; Amnesia; Anesthesia, Dental; Apnea; Carbon Dioxide; Double-Blind Method; Female; | 1991 |
12 other studies available for ketamine and Amnesia
| Article | Year |
|---|---|
MANAGEMENT OF AMNESTIC AND BEHAVIORAL DISORDERS AFTER KETAMINE ANESTHESIA.
Topics: Amnesia; Anesthesia; Anesthesia, General; Animals; Dipeptides; Ketamine; Mental Disorders; Neuroprot | 2019 |
Evaluation of the Memory Enhancing Activity of Dichloromethane Fraction of the Methanolic Extract of Pycnanthus angolensis Stem Bark on Experimental Models of Memory Impairment.
Topics: Acetylcholinesterase; Amnesia; Animals; Brain; Cholinesterase Inhibitors; Disease Models, Animal; Ga | 2019 |
Recovery from ketamine-induced amnesia by blockade of GABA-A receptor in the medial prefrontal cortex of mice.
Topics: Amnesia; Animals; Baclofen; Bicuculline; Catheters, Indwelling; Dose-Response Relationship, Drug; Ex | 2017 |
The influence of dopaminergic system in medial prefrontal cortex on ketamine-induced amnesia in passive avoidance task in mice.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Amnesia; Animals; Avoidance Learning; Do | 2016 |
Effects of 5-HT drugs in prefrontal cortex during memory formation and the ketamine amnesia-model.
Topics: Amnesia; Animals; Disease Models, Animal; Drug Delivery Systems; Ketamine; Male; Memory; Prefrontal | 2008 |
Perceptual organization in ketamine users: preliminary evidence of deficits on night of drug use but not 3 days later.
Topics: Adolescent; Adult; Amnesia; Delusions; Depersonalization; Dissociative Disorders; Excitatory Amino A | 2007 |
Ketamine as induction agent for caesarean section.
Topics: Amnesia; Anesthesia, General; Anesthesia, Obstetrical; Apgar Score; Cesarean Section; Diazepam; Drea | 1982 |
[Recovery after anesthesia with Diprivan].
Topics: Amnesia; Anesthesia Recovery Period; Anesthesia, Intravenous; Drug Delivery Systems; Etomidate; Huma | 1994 |
Anaesthesia for dilatation, evacuation and curettage in outpatients: comparison of subanaesthetic doses of ketamine and sodium methohexitone-nitrous oxide anaesthesia.
Topics: Adolescent; Adult; Amnesia; Analgesia; Anesthesia, Inhalation; Anesthesia, Intravenous; Communicatio | 1977 |
[Pharmacological correction of ketamine-impaired spatial memory of rats].
Topics: Amnesia; Animals; Aspartic Acid; Haloperidol; Hippocampus; Ketamine; Memory, Short-Term; Physostigmi | 1990 |
[The mechanisms of memory disorders at the stages in its acquisition and fixation].
Topics: Amnesia; Animals; Avoidance Learning; Conditioning, Classical; Dose-Response Relationship, Drug; Fem | 1988 |
[Antagonism of caerulein, a CCK-8 receptor agonist, to the behavioral effects of ketamine in mice and rats].
Topics: Amnesia; Animals; Ataxia; Behavior, Animal; Ceruletide; Haloperidol; Ketamine; Male; Mice; Motor Act | 1988 |