Ankle Fractures

Synonym
Ankle Fractures

Excerpt	Reference
"Ankle fractures are common and may be treated nonoperatively or by reduction and internal fixation."	( Weber, D; Weber, M, 2016)
"Ankle fractures are common and may require open reduction and internal fixation (ORIF)."	( Aiyer, AA; Allen, MK; Kaplan, JRM; Parrish, JM; Roche, MW; Vakharia, R; Vulcano, E, 2021)
"The incidence of ankle fractures is increasing, and risk factors for prolonged opioid use after ankle fracture fixation are unknown."	( Bariteau, JT; Broggi, MS; Kadakia, RJ; Oladeji, PO; Spenser, C, 2023)
"Ankle fractures are the most common intra-articular fractures."	( Jiang, J; Li, Z; Song, X; Wan, L; Wu, D; Yuan, D; Zhang, S, 2021)
"Although ankle fractures are one of the most common injuries seen by orthopedic trauma surgeons, there is no uniform protocol for the diagnosis and treatment of ankle fractures in the elderly, and there are many controversial indications for surgery."	( Cui, Z; Hu, Z; Tang, D; Tang, Y; Wang, Q; Xin, D; Yue, Z; Zeng, L; Zhao, W, 2022)
"Ankle fractures are common orthopaedic injuries that may be indicated for open reduction internal fixation (ORIF)."	( Dhodapkar, MM; Grauer, JN; Halperin, SJ; Modrak, M; Oghenesume, OP; Yoo, BJ, 2023)

Excerpt	Reference
"Patients (n = 1531) treated for ankle fractures (OTA/AO 43B or 44) over 16 years were identified."	( Audet, M; Benedick, A; Kavanagh, M; Simske, NM; Vallier, HA, 2021)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	11 (9.48)	23.3326
1990's	0 (0.00)	12.5806
2000's	0 (0.00)	18.1394
2010's	60 (51.72)	28.8240
2020's	45 (38.79)	9.53

Drug	Relationship Strength	Studies	Trials
methane	low	2	0
lactic acid	medium	2	1
dalteparin	medium	1	1
nickel	low	1	0
aspirin	low	1	0
diclofenac	medium	2	2
fentanyl	medium	1	1
glyphosate	low	1	0
hydroxychloroquine	low	1	0
lidocaine	low	3	0
ketamine	low	1	0
ketorolac	low	4	0
midazolam	low	1	0
nitroglycerin	low	1	0
procaine	low	1	0
sodium fluoride	low	1	0
prednisolone	low	1	0
thiophenes	low	1	0
isoxazoles	medium	1	1
octyl 2-cyanoacrylate	medium	2	1
titanium	medium	7	1
gadolinium	low	1	0
calcium sulfate	low	3	0
trolamine salicylate	low	23	0
cadusafos	low	1	0
vitamin b 6	low	1	0
((18)O)water	low	1	0
parecoxib	medium	1	1
ropivacaine	medium	5	2
darunavir	low	1	0
dabigatran	low	1	0
ritonavir	low	1	0
safranine t	low	1	0
humulene	low	1	0
morphine	medium	6	2
sinomenine	low	1	0
morphinans	low	1	0
rivaroxaban	low	1	0
indocyanine green	low	3	0
vendex	low	2	0
cardiovascular agents	low	1	0
interleukin-8	low	1	0
warfarin	low	1	0
rifampin	low	1	0

Protein Targets (524)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
RAR-related orphan receptor gamma	7	0	0	7
ATAD5 protein, partial	1	0	0	1
GLS protein	5	0	0	5
Microtubule-associated protein tau	4	0	0	4
Smad3	1	0	0	1
aldehyde dehydrogenase 1 family, member A1	6	0	0	6
thyroid stimulating hormone receptor	4	0	0	4
nuclear receptor subfamily 1, group I, member 3	2	0	0	2
progesterone receptor	4	0	0	4
EWS/FLI fusion protein	11	0	0	11
retinoic acid nuclear receptor alpha variant 1	7	0	0	7
retinoid X nuclear receptor alpha	5	0	0	5
estrogen-related nuclear receptor alpha	7	0	0	7
estrogen nuclear receptor alpha	12	0	0	12
peroxisome proliferator activated receptor gamma	4	0	0	4
aryl hydrocarbon receptor	3	0	0	3
chromobox protein homolog 1	4	0	0	4
thyroid hormone receptor beta isoform 2	4	0	0	4
peripheral myelin protein 22	2	0	0	2
cytochrome P450 3A4 isoform 1	2	0	0	2
Gamma-aminobutyric acid receptor subunit pi	2	1	0	3
ATP-binding cassette sub-family C member 3	0	8	0	8
Multidrug resistance-associated protein 4	0	8	0	8
Solute carrier family 22 member 6	0	2	0	2
Carbonic anhydrase 12	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	1	0	3
Bile salt export pump	0	3	0	3
Voltage-dependent calcium channel gamma-2 subunit	3	0	0	3
Bile salt export pump	0	14	0	14
Cytochrome P450 2B1	0	0	0	1
Cytochrome P450 1A1	0	0	0	1
Carbonic anhydrase 1	0	5	0	5
Carbonic anhydrase 2	0	5	0	5
Myoglobin	0	1	0	1
Cytochrome P450 1A1	0	0	1	2
Cytochrome P450 1A2	0	1	0	2
Prostaglandin G/H synthase 1	0	3	0	3
Carbonic anhydrase 3	0	1	0	1
Cytochrome P450 3A4	0	6	1	8
Cytochrome P450 2D6	0	2	0	2
Cytochrome P450 2C9	0	6	0	7
Polyunsaturated fatty acid lipoxygenase ALOX15	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	2	1	0	3
Sulfotransferase 1A1	0	0	0	1
Gamma-aminobutyric acid receptor subunit delta	2	1	0	3
Gamma-aminobutyric acid receptor subunit gamma-2	2	1	0	3
UDP-glucuronosyltransferase 1-6	0	3	0	4
Glutamate receptor 2	3	0	0	3
Gamma-aminobutyric acid receptor subunit alpha-5	2	1	0	3
Gamma-aminobutyric acid receptor subunit alpha-3	2	1	0	3
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	4	0	5
Carbonic anhydrase 4	0	1	0	1
Prostaglandin G/H synthase 1	0	5	0	5
Carbonic anhydrase 6	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	2	1	0	3
Gamma-aminobutyric acid receptor subunit alpha-2	2	1	0	3
Gamma-aminobutyric acid receptor subunit alpha-4	2	1	0	3
Gamma-aminobutyric acid receptor subunit gamma-3	2	1	0	3
Gamma-aminobutyric acid receptor subunit alpha-6	2	1	0	3
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Prostaglandin G/H synthase 2	0	6	0	7
Carbonic anhydrase 7	0	1	0	1
Nuclear receptor ROR-gamma	2	0	0	2
Cytochrome P450 2J2	0	4	0	4
Gamma-aminobutyric acid receptor subunit alpha-1	2	2	0	4
Gamma-aminobutyric acid receptor subunit beta-3	2	1	0	3
Gamma-aminobutyric acid receptor subunit beta-2	2	1	0	3
Carbonic anhydrase 9	0	2	0	2
GABA theta subunit	2	1	0	3
Canalicular multispecific organic anion transporter 1	0	8	0	8
Carbonic anhydrase 15	0	1	0	1
Carbonic anhydrase 13	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	2	1	0	3
Carbonic anhydrase 14	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	1	0	1
toxin B	0	0	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	3	0	0	3
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	1	0	0	1
Chain A, Phospholipase A2 isoform 3	0	0	1	1
Chain A, HADH2 protein	2	0	0	2
Chain B, HADH2 protein	2	0	0	2
Chain A, 2-oxoglutarate Oxygenase	2	0	0	2
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
interleukin 8	2	0	0	2
thioredoxin reductase	4	0	0	4
AR protein	9	0	0	9
hypothetical protein, conserved	1	0	0	1
cytochrome P450 family 3 subfamily A polypeptide 4	10	0	0	10
glucocorticoid receptor [Homo sapiens]	6	0	0	6
cytochrome P450 2D6	5	0	0	5
glucocerebrosidase	1	0	0	1
peroxisome proliferator-activated receptor delta	3	0	0	3
Rac1 protein	0	0	1	1
IDH1	2	0	0	2
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
euchromatic histone-lysine N-methyltransferase 2	7	0	0	7
Bloom syndrome protein isoform 1	1	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	1	0	0	1
DNA polymerase iota isoform a (long)	1	0	0	1
DNA polymerase kappa isoform 1	3	0	0	3
muscarinic acetylcholine receptor M1	3	0	0	3
lethal factor (plasmid)	1	0	0	1
Prostaglandin-H2 D-isomerase	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Prostaglandin G/H synthase 2	0	1	0	1
Epidermal growth factor receptor	0	1	0	1
Fatty acid-binding protein, liver	0	4	0	4
Integrin beta-3	1	1	0	2
Myeloperoxidase	0	1	0	1
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Integrin alpha-IIb	1	1	0	2
Glutathione hydrolase 1 proenzyme	0	1	0	1
Adenosine receptor A1	0	1	0	1
Adenosine receptor A2a	0	1	0	1
Substance-P receptor	0	1	0	1
Urotensin-2 receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Ras-related protein Rab-2A	0	0	1	1
Prostaglandin G/H synthase 2	0	2	0	2
Rho-associated protein kinase 2	0	1	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	4	1	5
Sigma non-opioid intracellular receptor 1	0	1	1	2
Potassium channel subfamily K member 3	0	3	0	3
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 2	0	1	1	2
Potassium channel subfamily K member 9	0	1	0	1
G	5	0	0	5
Solute carrier family 22 member 2	0	2	0	2
Prothrombin	0	3	0	3
Coagulation factor X	0	3	0	3
Plasminogen	0	1	0	1
Coagulation factor XII	0	2	0	2
Tissue-type plasminogen activator	0	1	0	1
Interferon beta	7	0	0	7
HLA class I histocompatibility antigen, B alpha chain	5	0	0	5
Vitamin K-dependent protein C	0	1	0	1
Serine protease hepsin	0	1	0	1
Trypsin-1	0	1	0	1
Trypsin-2	0	1	0	1
Muscarinic acetylcholine receptor M1	0	2	0	2
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	2	0	2
Trypsin-3	0	1	0	1
Multidrug and toxin extrusion protein 2	0	2	0	2
Inositol hexakisphosphate kinase 1	5	0	0	5
Multidrug and toxin extrusion protein 1	0	4	0	4
cytochrome P450 2C9, partial	5	0	0	5
Chain A, Pol Polyprotein	0	1	0	1
Chain A, Pol Polyprotein	0	1	0	1
Chain B, Pol Polyprotein	0	1	0	1
Chain A, Pol Polyprotein	0	1	0	1
Chain B, Pol Polyprotein	0	1	0	1
Chain A, HIV-1 Protease	0	1	0	1
Chain B, HIV-1 Protease	0	1	0	1
Chain A, protease	0	1	0	1
Chain B, protease	0	1	0	1
Chain A, Protease	0	1	0	1
Chain B, Protease	0	1	0	1
Chain A, Protease	0	1	0	1
Chain B, Protease	0	1	0	1
Chain A, Protease	0	1	0	1
Chain B, Protease	0	1	0	1
Chain A, Protease (Retropepsin)	0	0	1	1
Chain B, Protease (Retropepsin)	0	0	1	1
Chain A, Protease (Retropepsin)	0	0	1	1
Chain B, Protease (Retropepsin)	0	0	1	1
Chain A, HIV-1 Protease	0	1	0	1
Chain B, HIV-1 Protease	0	1	0	1
Chain A, HIV-1 Protease	0	1	0	1
Chain B, HIV-1 Protease	0	1	0	1
Chain A, HIV-1 Protease	0	1	0	1
Chain B, HIV-1 Protease	0	1	0	1
Chain A, HIV-1 Protease	0	1	0	1
Chain B, HIV-1 Protease	0	1	0	1
Chain A, HIV-1 Protease	0	1	0	1
Chain B, HIV-1 Protease	0	1	0	1
Chain A, HIV-1 Protease	0	1	0	1
Chain B, HIV-1 Protease	0	1	0	1
Chain A, Protease	0	0	1	1
Chain B, Protease	0	0	1	1
Chain A, Protease	0	0	1	1
Chain B, Protease	0	0	1	1
Chain A, Protease	0	0	1	1
Chain B, Protease	0	0	1	1
Chain A, Protease	0	0	1	1
Chain B, Protease	0	0	1	1
Chain A, Protease	0	0	1	1
Chain B, Protease	0	0	1	1
Chain A, Protease	0	0	1	1
Chain B, Protease	0	0	1	1
Chain A, Protease	0	0	1	1
Chain B, Protease	0	0	1	1
Chain A, Protease	0	0	1	1
Chain B, Protease	0	0	1	1
Chain A, Protease	0	0	1	1
Chain B, Protease	0	0	1	1
Chain A, Protease	0	0	1	1
Chain B, Protease	0	0	1	1
Chain A, Protease	0	0	1	1
Chain B, Protease	0	0	1	1
Chain A, Protease	0	0	1	1
Chain B, Protease	0	0	1	1
Chain A, Protease	0	1	0	1
Chain B, Protease	0	1	0	1
Chain A, HIV-1 protease	0	0	1	1
Chain B, HIV-1 protease	0	0	1	1
Chain A, HIV-1 protease	0	0	1	1
Chain B, HIV-1 protease	0	0	1	1
Chain A, HIV-1 Protease	0	0	1	1
Chain B, HIV-1 Protease	0	0	1	1
Chain A, Protease	0	0	1	1
Chain B, Protease	0	0	1	1
Chain A, Protease	0	1	0	1
Chain B, Protease	0	1	0	1
Chain A, Protease	0	1	0	1
Chain B, Protease	0	1	0	1
Chain A, Protease	0	1	0	1
Chain B, Protease	0	1	0	1
Chain A, Protease	0	1	0	1
Chain B, Protease	0	1	0	1
Chain A, Protease	0	1	0	1
Chain B, Protease	0	1	0	1
Chain A, HIV-1 protease	0	1	0	1
Chain B, HIV-1 protease	0	1	0	1
Chain A, HIV-1 protease	0	1	0	1
Chain B, HIV-1 protease	0	1	0	1
Chain A, HIV-1 protease	0	1	0	1
Chain B, HIV-1 protease	0	1	0	1
Chain A, Protease	0	0	1	1
Chain B, Protease	0	0	1	1
Chain A, Pol polyprotein	0	1	0	1
Chain B, Pol polyprotein	0	1	0	1
TDP1 protein	6	0	0	6
pregnane X nuclear receptor	8	0	0	8
nuclear receptor subfamily 1, group I, member 2	2	0	0	2
potassium voltage-gated channel subfamily H member 2 isoform d	2	0	0	2
geminin	4	0	0	4
Gag-Pol polyprotein	0	2	0	2
ATP-dependent translocase ABCB1	0	5	0	5
Replicase polyprotein 1ab	0	2	1	3
Replicase polyprotein 1ab	0	3	1	4
Gag-Pol polyprotein	0	1	1	2
Potassium voltage-gated channel subfamily E member 1	0	1	0	1
Alpha-1B adrenergic receptor	0	2	0	2
Alpha-1D adrenergic receptor	0	2	0	2
Alpha-1A adrenergic receptor	0	2	0	2
Potassium voltage-gated channel subfamily KQT member 1	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	5	0	5
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Sodium channel protein type 5 subunit alpha	0	2	0	2
Protease	0	4	1	9
Gag-Pol polyprotein	0	1	0	1
Potassium voltage-gated channel subfamily D member 3	0	1	0	1
Protease	0	4	3	8
Aldo-keto reductase family 1 member B10	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Dihydrofolate reductase	0	1	0	1
Cytochrome c oxidase subunit 2	0	1	0	1
Transthyretin	0	0	1	3
Albumin	0	2	4	8
Interleukin-8	0	1	0	1
Calcium/calmodulin-dependent protein kinase type II subunit alpha	0	1	0	1
Fatty acid-binding protein, intestinal	0	2	1	3
Aldo-keto reductase family 1 member B1	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	2	0	3
UDP-glucuronosyltransferase 1A4	0	2	0	2
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
C-X-C chemokine receptor type 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
UDP-glucuronosyltransferase 1A3	0	0	0	2
UDP-glucuronosyltransferase 2B10	0	2	0	2
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Solute carrier family 22 member 6	0	1	0	2
Prostaglandin G/H synthase 1	0	1	0	1
Carbonic anhydrase 4	0	1	0	1
P2Y purinoceptor 12	0	1	0	1
UDP-glucuronosyltransferase 1A7	0	1	0	1
UDP-glucuronosyltransferase 1A10	0	1	0	1
Luciferase	3	0	0	3
Solute carrier family 22 member 1	0	4	0	4
Nuclear receptor subfamily 1 group I member 2	0	0	3	3
D(2) dopamine receptor	0	1	0	1
Amine oxidase [flavin-containing] A	0	1	0	1
D(4) dopamine receptor	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
Delta-type opioid receptor	0	3	0	4
Delta-type opioid receptor	0	4	1	6
Mu-type opioid receptor	0	5	2	10
Kappa-type opioid receptor	0	3	1	5
Histamine H1 receptor	0	1	0	1
Mu-type opioid receptor	0	6	2	9
D(3) dopamine receptor	0	1	0	1
Delta-type opioid receptor	0	4	1	6
Kappa-type opioid receptor	0	4	0	4
Kappa-type opioid receptor	0	6	1	8
Mu-type opioid receptor	0	3	1	6
Mu-type opioid receptor	0	4	0	4
Sigma non-opioid intracellular receptor 1	0	2	0	2
Chain A, 3-phosphoshikimate 1-carboxyvinyltransferase	0	1	0	1
Chain A, 3-phosphoshikimate 1-carboxyvinyltransferase	0	1	0	1
Glutamine synthetase	0	1	0	1
Cytochrome P450 71B1	0	1	0	2
Glutamine synthetase	0	1	0	1
2-dehydro-3-deoxyphosphooctonate aldolase	0	1	0	1
Genome polyprotein	0	1	0	1
Spike glycoprotein	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
lamin isoform A-delta10	4	0	0	4
Transmembrane protease serine 2	0	0	1	1
Procathepsin L	0	0	1	1
Muscarinic acetylcholine receptor M2	0	2	0	2
Muscarinic acetylcholine receptor M4	0	1	0	1
Muscarinic acetylcholine receptor M5	0	1	0	1
Alpha-2A adrenergic receptor	0	1	1	2
Replicase polyprotein 1a	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Muscarinic acetylcholine receptor M1	0	1	0	1
Alpha-2B adrenergic receptor	0	1	0	1
Alpha-2C adrenergic receptor	0	1	0	1
Muscarinic acetylcholine receptor M3	0	1	0	1
Alpha-1D adrenergic receptor	0	2	0	2
Spike glycoprotein	1	0	1	2
Sigma intracellular receptor 2	0	1	0	1
Cyclic GMP-AMP synthase	0	1	0	1
Angiotensin-converting enzyme 2	0	0	1	1
Toll-like receptor 9	0	1	0	1
Toll-like receptor 7	0	1	0	1
hypoxia-inducible factor 1 alpha subunit	2	0	0	2
Fumarate hydratase	2	0	0	2
GALC protein	1	0	0	1
GLI family zinc finger 3	4	0	0	4
estrogen receptor 2 (ER beta)	3	0	0	3
farnesoid X nuclear receptor	2	0	0	2
polyprotein	2	0	0	2
activating transcription factor 6	2	0	0	2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	2	0	0	2
heat shock protein beta-1	1	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 1	3	0	0	3
Cellular tumor antigen p53	4	0	0	4
Cytochrome P450 144	0	0	1	1
Steroid C26-monooxygenase	0	0	1	1
Steroid C26-monooxygenase	0	0	1	1
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Acetylcholinesterase	0	2	0	2
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Rap guanine nucleotide exchange factor 3	1	0	0	1
Glutamate receptor ionotropic, NMDA 1	0	2	0	2
Sodium channel protein type 4 subunit alpha	0	2	0	2
Cholinesterase	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	2	0	2
Glutamate receptor ionotropic, NMDA 2B	0	2	0	2
Glutamate receptor ionotropic, NMDA 2C	0	2	0	2
Glutamate receptor ionotropic, NMDA 1	0	2	0	2
Glutamate receptor ionotropic, NMDA 2A	0	2	0	2
Glutamate receptor ionotropic, NMDA 2B	0	2	0	2
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Glutamate receptor ionotropic, NMDA 2D	0	2	0	2
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	2	0	2
Glutamate receptor ionotropic, NMDA 3A	0	2	0	2
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
ras-related protein Rab-9A	1	0	0	1
Caspase-1	0	2	0	2
Caspase-3	0	1	0	1
Caspase-4	0	1	0	1
Caspase-5	0	1	0	1
Caspase-9	0	1	0	1
Cell division control protein 42 homolog	0	1	0	1
Ras-related C3 botulinum toxin substrate 1	0	1	0	1
Serine/threonine-protein kinase PAK 1	0	1	0	1
Ataxin-2	3	0	0	3
acetylcholinesterase	1	0	0	1
thyroid stimulating hormone receptor	1	0	0	1
v-jun sarcoma virus 17 oncogene homolog (avian)	2	0	0	2
cellular tumor antigen p53 isoform a	1	0	0	1
Chain A, Beta-lactamase	3	0	0	3
vitamin D (1,25- dihydroxyvitamin D3) receptor	4	0	0	4
mitogen-activated protein kinase 1	2	0	0	2
flap endonuclease 1	1	0	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
Sodium channel protein type 9 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily D member 2	0	1	0	1
Potassium channel subfamily K member 18	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
ATP-dependent translocase ABCB1	0	3	0	3
Translocator protein	0	1	1	2
ATP-dependent translocase ABCB1	0	3	0	3
Stromelysin-1	0	1	0	1
Matrilysin	0	1	0	1
Multidrug transporter MdfA	0	1	0	1
Matrix metalloproteinase-9	0	1	0	1
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
Protein-arginine deiminase type-4	0	2	0	2
Opioid receptor, delta 1b	0	1	0	1
Opioid receptor homologue	0	1	0	1
Acyl-CoA desaturase 1	0	1	0	1
Muscarinic acetylcholine receptor M3	0	1	0	1
Muscarinic acetylcholine receptor M4	0	1	0	1
Muscarinic acetylcholine receptor M5	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
Histidine decarboxylase	0	0	1	1
Proteinase-activated receptor 1	0	1	1	2
Sodium-dependent serotonin transporter	0	1	0	1
Kappa-type opioid receptor	0	2	1	4
Nociceptin receptor	0	1	0	1
5-hydroxytryptamine receptor 7	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Beta-2 adrenergic receptor	0	1	0	1
Mas-related G-protein coupled receptor member X2	0	0	2	2
Mu-type opioid receptor	0	1	0	1
Nuclear receptor subfamily 4 group A member 2	0	1	0	1
luciferase	0	0	0	1
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	3	0	0	3
nuclear factor erythroid 2-related factor 2 isoform 2	1	0	0	1
Estrogen receptor	0	2	0	2
Glucocorticoid receptor	0	2	1	9
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Glycine receptor subunit alpha-1	0	2	0	2
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	0	2	1	3
Androgen receptor	0	2	0	2
Glutamine synthetase	0	0	1	1
Androgen receptor	0	1	0	1
Glycine receptor subunit beta	0	2	0	2
Glycine receptor subunit alpha-2	0	2	0	2
Glycine receptor subunit alpha-3	0	2	0	2
Histamine H1 receptor	0	0	1	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	0	2
ATPase family AAA domain-containing protein 5	2	0	0	2
cytochrome P450 2D6 isoform 1	1	0	0	1
histone acetyltransferase KAT2A isoform 1	2	0	0	2
Chain A, Cruzipain	2	0	0	2
15-lipoxygenase, partial	1	0	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	1	0	0	1
Solute carrier organic anion transporter family member 1A4	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	4	0	4
NH(3)-dependent NAD(+) synthetase	0	1	0	1
60 kDa heat shock protein, mitochondrial	0	1	0	1
Cytochrome P450 2B6	0	0	1	1
Arylacetamide deacetylase	0	1	0	2
Alpha-synuclein	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	1	0	1
Solute carrier organic anion transporter family member 1A2	0	1	0	1
Histamine H2 receptor	1	0	0	1
10 kDa heat shock protein, mitochondrial	0	1	0	1
Glutathione S-transferase omega-1	0	1	0	1
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
Thiosulfate sulfurtransferase	0	1	0	1
Lanosterol 14-alpha demethylase	0	1	0	1
60 kDa chaperonin	0	1	0	1
10 kDa chaperonin	0	1	0	1
Solute carrier organic anion transporter family member 1B3	0	4	0	5
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	2	0	2
Solute carrier organic anion transporter family member 1B1	0	4	0	5
Chain A, HIV-1 PROTEASE	0	1	0	1
Chain B, HIV-1 PROTEASE	0	1	0	1
Chain A, POL polyprotein	0	1	0	1
Chain B, POL polyprotein	0	1	0	1
Chain A, POL polyprotein	0	1	0	1
Chain B, POL polyprotein	0	1	0	1
Chain A, Ferritin light chain	1	0	0	1
Chain A, Endothiapepsin	0	1	0	1
Chain A, Endothiapepsin	0	1	0	1
SMAD family member 2	1	0	0	1
SMAD family member 3	1	0	0	1
alpha-galactosidase	1	0	0	1
vitamin D3 receptor isoform VDRA	2	0	0	2
nuclear receptor ROR-gamma isoform 1	1	0	0	1
neuropeptide S receptor isoform A	1	0	0	1
Solute carrier family 22 member 3	0	1	0	1
Gag-Pol polyprotein	0	1	0	1
Gag-Pol polyprotein	0	1	0	1
Gag-Pol polyprotein	0	1	0	1
Cytochrome P450 3A5	0	1	0	1
Substance-K receptor	0	2	0	2
Thromboxane-A synthase	0	1	0	1
Gag-Pol polyprotein	0	1	0	1
Cytochrome P450 2C19	0	1	0	1
Vasopressin V1a receptor	0	2	0	2
Thromboxane-A synthase	0	0	0	1
Sodium/bile acid cotransporter	0	1	0	1
Plasmepsin V	0	1	0	1
Chain A, Activated Factor Xa Heavy Chain	0	1	0	1
Suppressor of tumorigenicity 14 protein	0	1	0	1
Cyclin-dependent kinase 2	0	1	0	1
Carbonic anhydrase	0	1	0	1
Eyes absent homolog 2	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Solute carrier family 22 member 8	0	1	0	1
Solute carrier family 2, facilitated glucose transporter member 9	0	1	1	2
Guanine deaminase	0	1	0	1
phosphopantetheinyl transferase	1	0	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	1	0	0	1
PPM1D protein	1	0	0	1
thyroid hormone receptor beta isoform a	1	0	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
Albumin	0	0	1	1
Proprotein convertase subtilisin/kexin type 7	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	2	0	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(1)

Research Excerpts

Overview

Treatment

Research

Studies (116)

Protein Targets (524)

Ankle Fractures

Synonyms(1)

Research Excerpts

Overview

Treatment

Research

Studies (116)

Drugs Studied (59)

Protein Targets (524)