ketamine and Ataxia
ketamine has been researched along with Ataxia in 25 studies
Ketamine: A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.
ketamine : A member of the class of cyclohexanones in which one of the hydrogens at position 2 is substituted by a 2-chlorophenyl group, while the other is substituted by a methylamino group.
Ataxia: Impairment of the ability to perform smoothly coordinated voluntary movements. This condition may affect the limbs, trunk, eyes, pharynx, larynx, and other structures. Ataxia may result from impaired sensory or motor function. Sensory ataxia may result from posterior column injury or PERIPHERAL NERVE DISEASES. Motor ataxia may be associated with CEREBELLAR DISEASES; CEREBRAL CORTEX diseases; THALAMIC DISEASES; BASAL GANGLIA DISEASES; injury to the RED NUCLEUS; and other conditions.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "To observe the symptoms similar to schizophrenia in mice after ketamine single or continuous injection and to evaluate the feasibility of schizophrenia model injected with different dose of ketamine." | 7.75 | [Behavior study of ketamine-induced symptoms similar to schizophrenia in mice]. ( Bian, SZ; Gu, ZL; Guo, CY; Jiang, XG; Liu, WL; Zhao, YB, 2009) |
| "An anticonvulsant action of ketamine, a noncompetitive N-methyl-D-aspartate (NMDA) antagonist (5-40 mg/kg IP), on the bicuculline-induced (3-8 mg/kg IP) or picrotoxin-induced seizures (3-6 mg/kg IP) was assessed in male Wistar rats aged 7, 12, 18, 25 and 90 days." | 7.68 | Ketamine suppresses both bicuculline- and picrotoxin-induced generalized tonic-clonic seizures during ontogenesis. ( Mares, P; Rokyta, R; Velísek, L; Velísková, J, 1990) |
| "Effects of physostigmine on ketamine-induced anesthesia and analgesia were studied in male Sprague-Dawley rats using behavioral tests." | 7.68 | Antagonistic effect of physostigmine on ketamine-induced anesthesia. ( Ikeda, T; Kishi, R; Mimura, M; Miyake, H; Namiki, A, 1990) |
| "Crocin's ability to counteract hypermotility, stereotypies and ataxia induced by ketamine was evaluated in a motor activity cage." | 3.80 | Crocins, the active constituents of Crocus Sativus L., counteracted ketamine-induced behavioural deficits in rats. ( Georgiadou, G; Grivas, V; Pitsikas, N; Tarantilis, PA, 2014) |
| "To observe the symptoms similar to schizophrenia in mice after ketamine single or continuous injection and to evaluate the feasibility of schizophrenia model injected with different dose of ketamine." | 3.75 | [Behavior study of ketamine-induced symptoms similar to schizophrenia in mice]. ( Bian, SZ; Gu, ZL; Guo, CY; Jiang, XG; Liu, WL; Zhao, YB, 2009) |
| "An anticonvulsant action of ketamine, a noncompetitive N-methyl-D-aspartate (NMDA) antagonist (5-40 mg/kg IP), on the bicuculline-induced (3-8 mg/kg IP) or picrotoxin-induced seizures (3-6 mg/kg IP) was assessed in male Wistar rats aged 7, 12, 18, 25 and 90 days." | 3.68 | Ketamine suppresses both bicuculline- and picrotoxin-induced generalized tonic-clonic seizures during ontogenesis. ( Mares, P; Rokyta, R; Velísek, L; Velísková, J, 1990) |
| "Effects of physostigmine on ketamine-induced anesthesia and analgesia were studied in male Sprague-Dawley rats using behavioral tests." | 3.68 | Antagonistic effect of physostigmine on ketamine-induced anesthesia. ( Ikeda, T; Kishi, R; Mimura, M; Miyake, H; Namiki, A, 1990) |
| "Evaluations of analgesia, sedation, ataxia, heart rate, arterial pressure, respiratory rate, skin temperature and rectal temperature were obtained at 0 (basal), 5, 10, 15, 30, 45, 60, 75, 90 minutes after epidural injection, and then at 30-minute intervals until loss of analgesia occurred." | 1.36 | Segmental dorsolumbar epidural analgesia via the caudal approach using multiple port catheters with ketamine or lidocaine or in combination in cattle. ( Bertoni, RA; DeRossi, R; Frazílio, FO; Ruzzon, RH; Verde-Selva, AB, 2010) |
| " Ketamine, PCP, and MK-801 enhanced catalepsy along inverted U-shaped dose-response curves likely because higher doses affected motor coordination, which limited their catalepsy-enhancing effects." | 1.35 | Cataleptic effects of gamma-hydroxybutyrate (GHB) and baclofen in mice: mediation by GABA(B) receptors, but differential enhancement by N-methyl-d-aspartate (NMDA) receptor antagonists. ( France, CP; Koek, W, 2008) |
| "The study was conducted in 9 healthy adult goats of either sex, weighing 15-20 kg, to evaluate and compare the clinicophysiological effects of spinally administered ketamine alone and in combination with xylazine and medetomidine." | 1.34 | Clinicophysiological effects of spinally administered ketamine and its combination with xylazine and medetomidine in healthy goats. ( Aithal, HP; Kinjavdekar, P; Pawde, AM; Singh, GR, 2007) |
| "Ketamine hydrochloride was administered intravenously (at a dose of two milligrams per kilogram of body weight) in ninety-nine of the patients and intramuscularly (at a dose of four milligrams per kilogram of body weight) in the other fifteen." | 1.31 | Ketamine sedation for the reduction of children's fractures in the emergency department. ( Green, NE; McCarty, EC; Mencio, GA; Walker, LA, 2000) |
| "Recovery to walking without incoordination was also rapid (< 2 h) and no abnormal behavioural patterns were observed during recovery." | 1.29 | The effect of intravenous administration of variable-dose midazolam after fixed-dose ketamine in healthy awake cats. ( Farver, TB; Ilkiw, JE; McNeal, D; Steffey, EP; Suter, CM, 1996) |
| "In rhesus monkeys, metaphit produced ataxia and convulsions but did not induce catalepsy, anesthesia or PCP-like discriminative stimulus effects." | 1.27 | Metaphit, a proposed phencyclidine receptor acylator: phencyclidine-like behavioral effects and evidence of absence of antagonist activity in pigeons and in rhesus monkeys. ( Jacobson, AE; Koek, W; Lessor, RA; Rice, KC; Woods, JH, 1986) |
Research
Studies (25)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (36.00) | 18.7374 |
| 1990's | 5 (20.00) | 18.2507 |
| 2000's | 6 (24.00) | 29.6817 |
| 2010's | 4 (16.00) | 24.3611 |
| 2020's | 1 (4.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Bigge, CF | 1 |
| Malone, TC | 1 |
| Hays, SJ | 1 |
| Johnson, G | 1 |
| Novak, PM | 1 |
| Lescosky, LJ | 1 |
| Retz, DM | 1 |
| Ortwine, DF | 1 |
| Probert, AW | 1 |
| Coughenour, LL | 1 |
| Browne, CA | 1 |
| Wulf, HA | 1 |
| Jacobson, ML | 1 |
| Oyola, MG | 1 |
| Wu, TJ | 1 |
| Lucki, I | 1 |
| Zuo, D | 1 |
| Liu, Y | 2 |
| Liu, Z | 1 |
| Cui, J | 1 |
| Zhou, X | 1 |
| Li, Z | 1 |
| Wu, Y | 1 |
| Lai, CC | 1 |
| Lee, LJ | 1 |
| Yin, HS | 1 |
| Georgiadou, G | 1 |
| Grivas, V | 1 |
| Tarantilis, PA | 1 |
| Pitsikas, N | 1 |
| Liu, WL | 1 |
| Bian, SZ | 1 |
| Gu, ZL | 1 |
| Jiang, XG | 1 |
| Guo, CY | 1 |
| Zhao, YB | 1 |
| DeRossi, R | 2 |
| Bertoni, RA | 1 |
| Ruzzon, RH | 1 |
| Verde-Selva, AB | 1 |
| Frazílio, FO | 1 |
| Junqueira, AL | 1 |
| Beretta, MP | 1 |
| Maas, JW | 1 |
| Vogt, SK | 1 |
| Chan, GC | 1 |
| Pineda, VV | 1 |
| Storm, DR | 1 |
| Muglia, LJ | 1 |
| Kinjavdekar, P | 1 |
| Singh, GR | 1 |
| Aithal, HP | 1 |
| Pawde, AM | 1 |
| Koek, W | 2 |
| France, CP | 1 |
| Wiley, JN | 1 |
| Downs, DA | 1 |
| Ilkiw, JE | 1 |
| Suter, CM | 1 |
| McNeal, D | 1 |
| Farver, TB | 1 |
| Steffey, EP | 1 |
| Jerram, AH | 1 |
| Smith, PF | 1 |
| Darlington, CL | 1 |
| McCarty, EC | 1 |
| Mencio, GA | 1 |
| Walker, LA | 1 |
| Green, NE | 1 |
| Marietta, MP | 1 |
| WAY, WL | 2 |
| Castagnoli, N | 1 |
| Trevor, AJ | 2 |
| Velísková, J | 1 |
| Velísek, L | 1 |
| Mares, P | 1 |
| Rokyta, R | 1 |
| Mimura, M | 1 |
| Namiki, A | 1 |
| Kishi, R | 1 |
| Ikeda, T | 1 |
| Miyake, H | 1 |
| Woods, JH | 1 |
| Jacobson, AE | 1 |
| Rice, KC | 1 |
| Lessor, RA | 1 |
| Vasar, EE | 1 |
| Allikmets, LKh | 1 |
| Soosaar, AKh | 1 |
| Manohar, S | 1 |
| Maxwell, D | 1 |
| Winters, WD | 3 |
| Glen, JB | 1 |
| Alcaraz, M | 2 |
| Cervantes, MY | 1 |
| Guzman-Flores, C | 2 |
| Cohen, ML | 1 |
| Chan, SL | 1 |
| Ferrar-Allado, T | 1 |
Other Studies
25 other studies available for ketamine and Ataxia
| Article | Year |
|---|---|
Synthesis and pharmacological evaluation of 4a-phenanthrenamine derivatives acting at the phencyclidine binding site of the N-methyl-D-aspartate receptor complex.
Topics: Animals; Ataxia; Binding Sites; Binding, Competitive; Brain; Mice; Models, Molecular; Phenanthrenes; | 1993 |
Long-term increase in sensitivity to ketamine's behavioral effects in mice exposed to mild blast induced traumatic brain injury.
Topics: Anesthetics, Dissociative; Animals; Ataxia; Behavior, Animal; Blast Injuries; Brain Concussion; Brai | 2022 |
Alcohol aggravates ketamine-induced behavioral, morphological and neurochemical alterations in adolescent rats: The involvement of CREB-related pathways.
Topics: Animals; Ataxia; Brain; Caspase 3; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent | 2018 |
Combinational effects of ketamine and amphetamine on behaviors and neurotransmitter systems of mice.
Topics: Amphetamine; Animals; Ataxia; Behavior, Animal; Brain; Central Nervous System Stimulants; Dopamine; | 2013 |
Crocins, the active constituents of Crocus Sativus L., counteracted ketamine-induced behavioural deficits in rats.
Topics: Animals; Antipsychotic Agents; Ataxia; Carotenoids; Ketamine; Male; Memory Disorders; Motor Activity | 2014 |
[Behavior study of ketamine-induced symptoms similar to schizophrenia in mice].
Topics: Animals; Ataxia; Disease Models, Animal; Dose-Response Relationship, Drug; Forensic Psychiatry; Inje | 2009 |
Segmental dorsolumbar epidural analgesia via the caudal approach using multiple port catheters with ketamine or lidocaine or in combination in cattle.
Topics: Analgesia, Epidural; Analgesics; Animals; Ataxia; Blood Pressure; Body Temperature; Catheters; Cattl | 2010 |
Analgesic and systemic effects of ketamine, xylazine, and lidocaine after subarachnoid administration in goats.
Topics: Adrenergic alpha-Agonists; Analgesia; Anesthetics, Dissociative; Anesthetics, Local; Animals; Ataxia | 2003 |
Calcium-stimulated adenylyl cyclases are critical modulators of neuronal ethanol sensitivity.
Topics: Adenylyl Cyclases; Analysis of Variance; Animals; Ataxia; Behavior, Animal; Blotting, Western; Calci | 2005 |
Clinicophysiological effects of spinally administered ketamine and its combination with xylazine and medetomidine in healthy goats.
Topics: Analgesia; Analgesia, Epidural; Anesthetics, Combined; Animals; Ataxia; Blood Chemical Analysis; Bod | 2007 |
Cataleptic effects of gamma-hydroxybutyrate (GHB) and baclofen in mice: mediation by GABA(B) receptors, but differential enhancement by N-methyl-d-aspartate (NMDA) receptor antagonists.
Topics: Anesthetics, Intravenous; Animals; Area Under Curve; Ataxia; Baclofen; Catalepsy; Data Interpretatio | 2008 |
Lack of antagonism by naloxone of the analgesic and locomotor stimulant actions of ketamine.
Topics: Analgesia; Animals; Ataxia; Dose-Response Relationship, Drug; Ketamine; Male; Motor Activity; Naloxo | 1982 |
The effect of intravenous administration of variable-dose midazolam after fixed-dose ketamine in healthy awake cats.
Topics: Anesthetics, Dissociative; Animals; Anti-Anxiety Agents; Ataxia; Behavior, Animal; Cats; Chi-Square | 1996 |
The effects of (+)-SKF10047 and ketamine hydrochloride on stereotyped behaviour, locomotor activity and ataxia in guinea pig.
Topics: Animals; Ataxia; Guinea Pigs; Ketamine; Motor Activity; Phenazocine; Reaction Time; Receptors, N-Met | 1996 |
Ketamine sedation for the reduction of children's fractures in the emergency department.
Topics: Analgesics; Anesthetics, Dissociative; Ataxia; Blood Pressure; Child; Child, Preschool; Cohort Studi | 2000 |
On the pharmacology of the ketamine enantiomorphs in the rat.
Topics: Animals; Ataxia; Brain; Dealkylation; Dose-Response Relationship, Drug; Hypnotics and Sedatives; In | 1977 |
Ketamine suppresses both bicuculline- and picrotoxin-induced generalized tonic-clonic seizures during ontogenesis.
Topics: Aging; Animals; Ataxia; Bicuculline; Ketamine; Male; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inb | 1990 |
Antagonistic effect of physostigmine on ketamine-induced anesthesia.
Topics: Anesthesia; Animals; Ataxia; Dose-Response Relationship, Drug; Ketamine; Male; Motor Activity; Physo | 1990 |
Metaphit, a proposed phencyclidine receptor acylator: phencyclidine-like behavioral effects and evidence of absence of antagonist activity in pigeons and in rhesus monkeys.
Topics: Acylation; Animals; Ataxia; Catalepsy; Columbidae; Discrimination Learning; Drug Synergism; Ketamine | 1986 |
[Antagonism of caerulein, a CCK-8 receptor agonist, to the behavioral effects of ketamine in mice and rats].
Topics: Amnesia; Animals; Ataxia; Behavior, Animal; Ceruletide; Haloperidol; Ketamine; Male; Mice; Motor Act | 1988 |
Development of EEG seizure activity during and after chronic ketamine administration in the rat.
Topics: Animals; Ataxia; Behavior, Animal; Brain; Catalepsy; Electrodes, Implanted; Electroencephalography; | 1972 |
The use of ketamine (CI-581) in feline anaesthetic practice.
Topics: Anesthesia, General; Animals; Ataxia; Atropine; Blood Pressure; Cats; Halothane; Heart Rate; Hydroge | 1973 |
The synergistic effect of reduced visual input on ketamine action: the possible role of the pineal gland.
Topics: Animals; Ataxia; Brain Chemistry; Cats; Denervation; Dose-Response Relationship, Drug; Electroenceph | 1973 |
Distribution in the brain and metabolism of ketamine in the rat after intravenous administration.
Topics: Animals; Ataxia; Brain; Brain Chemistry; Brain Stem; Cerebellum; Cerebral Cortex; Chromatography, Ga | 1973 |
The cataleptic state induced by ketamine: a review of the neuropharmacology of anesthesia.
Topics: Anesthetics; Animals; Ataxia; Catalepsy; Cats; Central Nervous System; Cyclohexanes; Electroencephal | 1972 |