Hypospadias

A birth defect due to malformation of the URETHRA in which the urethral opening is below its normal location. In the male, the malformed urethra generally opens on the ventral surface of the PENIS or on the PERINEUM. In the female, the malformed urethral opening is in the VAGINA.

Synonym
Hypospadias

Excerpt	Reference
"Coronal hypospadias is a frequent abnormality of the genitalia."	( Straffon, RA; Wacksman, J, 1979)
"Because hypospadias is the most common congenital defect of the male urethra and because in most cases the cause of this malformation is unknown, we examined the hypothesis that the etiology of the severe forms of this disorder, which is frequently associated with other genital anomalies, might be explained by receptor abnormalities."	( Romalo, G; Schlüter, M; Schweikert, HU, 1989)
"Hypospadias is the most common birth defect in males."	( Kau, N; Romalo, G; Schweikert, HU; Staib, P, 1994)
"The etiology of hypospadias is probably multifactorial and disruption of androgen production may have a role."	( Austin, PF; Cain, MP; Casale, AJ; Fallat, ME; Rink, RC; Siow, Y, 2002)
"Hypospadias is a birth defect that affects approximately seven in 1,000 male infants in the United States."	( , 2004)
"Boys with isolated hypospadias are more likely to have normal endocrine testicular and androgen end-organ functions, suggesting that transient disruption of morphogenetic events in early fetal life may be the predominant underlying cause."	( Bedecarrás, P; Bergadá, I; Campo, SM; Cassorla, FG; Codner, E; Gottlieb, S; Iñíguez, G; Okuma, C; Rey, RA; Trigo, R, 2005)
"Hypospadias is one of the most common malformations in man, with an incidence of 1:300 in newborn boys."	( Frisén, L; Kalbasi, M; Kockum, I; Lagerstedt, K; Nordenskjöld, A; Thai, HT, 2005)
"Hypospadias is a congenital defect of the male urethra and phallus."	( Karpman, E; Kurzrock, EA, 2004)
"Because penoscrotal hypospadias is rare, the effect is diluted when all forms of hypospadias are studied as a group."	( de Jong-Van den Berg, LT; de Walle, HE; Meijer, WM; van den Berg, MD; Verheij, JB, 2006)
"The incidence of hypospadias is increasing in young boys, but it remains unclear whether human exposure to endocrine disrupting chemicals plays a role."	( Axelstad, M; Boberg, J; Christiansen, S; Hass, U; Kortenkamp, A; Scholze, M, 2008)
"The etiology of hypospadias is regarded as a complex disorder with both genetic and environmental contributions."	( Ban, S; Kakizaki, H; Kasai, S; Kishi, R; Kurahashi, N; Moriya, K; Nonomura, K; Sata, F, 2008)
"Hypospadias is one of the most frequently occurring genital anomalies described in infants prenatally exposed to valproic acid (VA)."	( Fernández, P; Martínez-Frías, ML; Mejías, C; Prieto-Merino, D; Rodríguez-Pinilla, E, 2008)
"Hypospadias is almost constantly associated with an abnormality of the prepuce, resulting in incomplete prepuce."	( Benyoucef, N; Héloury, Y; Leclair, MD, 2008)
"We examined whether hypospadias is associated with maternal intake of folic acid containing vitamin/mineral supplements or dietary intake of nutrients related to one-carbon metabolism (folate, choline, vitamins B12 and B6, thiamine, riboflavin, methionine and zinc)."	( Carmichael, SL; Correa, A; Olney, RS; Shaw, GM; Yang, W, 2009)
"Hypospadias is one of the most common urogenital congenital anomalies affecting baby boys."	( Elliott, P; Geneletti, S; Iszatt, N; Nelson, P; Nieuwenhuijsen, MJ; Ormond, G; Toledano, MB, 2009)
"Hypospadias is a frequent congenital anomaly but in most cases an underlying cause is not found."	( Achermann, JC; Akkurt, I; Biebermann, H; Cetindag, C; Grüters, A; Hiort, O; Köhler, B; Lin, L; Mazen, I; Rossi, R, 2009)
"Hypospadias is a common birth defect in humans, yet its etiology and pattern of onset are largely unknown."	( Chen, H; Hinds, TD; Sanchez, ER; Shou, W; Yang, Z; Yong, W; Zhou, Y, 2010)
"Cryptorchidism and hypospadias are common genital birth defects that affect 2-9% and 0."	( Main, KM; Skakkebaek, NE; Toppari, J; Virtanen, HE, 2010)
"Hypospadias is one of the most common congenital malformations."	( Baskin, LS; Kalfa, N; Philibert, P; Sultan, C, 2011)
"Hypospadias is a common congenital error of genital development, the frequency of which is increasing."	( Bajpai, M; Ghosh, PK; Samtani, R; Saraswathy, KN; Vashisht, K, 2011)
"Hypospadias is a malformation of the penis due to an incomplete development of the male urethra, the exact etiology of which in the majority of cases remains unknown."	( Bernasconi, S; Bertolini, L; Bonatti, F; Ghizzoni, L; Minari, R; Neri, TM; Tassi, F; Viani, I; Vottero, A, 2011)
"Hypospadias is one of the most common congenital abnormalities of the genitalia frequently missed on prenatal sonograms."	( Bonasoni, MP; Cavalli, P; Centini, G; Pattacini, P; Tonni, G; Ventura, A, 2012)
"Hypospadias is a birth defect found in boys in which the urinary tract opening is not at the tip of the penis."	( Choi, H; Im, Y; Kim, J; Kim, Y; Lee, S, 2012)
"Hypospadias is one of the most common congenital anomalies in men."	( Macedo, A; Ortiz, V; Rondon, A, 2012)
"Hypospadias is a frequent congenital malformation, which severity is connected to the spongiosum divergence."	( Bouvattier, C, 2013)
"Hypospadias is a common structural birth defect (congenital abnormality) of the male genital organ."	( Ács, N; Czeizel, AE; Mavrogenis, S; Urban, R, 2014)
"Hypospadias is a congenital malformation with both environmental factors and genetic predisposition involved in the pathogenesis."	( Dokter, EM; Feitz, WF; Groothuismink, JM; Roeleveld, N; van der Biezen, JJ; van der Zanden, LF; van Rooij, IA; Wijers, CH, 2016)
"Hypospadias is a common malformation whose etiology is based upon perturbation of normal penile development."	( Baskin, L; Cao, M; Cooke, P; Cunha, GR; Risbridger, G; Shen, J; Sinclair, AW, 2016)
"Hypospadias is a relatively common birth defect affecting the male urinary tract."	( Band, LE; Emch, M; Langlois, P; Luben, TJ; Meyer, RE; Mosley, B; Olshan, AF; Weyer, P; Winston, JJ, 2016)
"Hypospadias is one of the most common birth defects in the world."	( Amato, CM; McCoy, KA, 2016)
"Hypospadias is one of the most common forms of congenital malformation of the male external genitalia worldwide."	( Fazeli, Z; Ghanbari, M; Mirfakhraie, R; Omrani, MD; Omrani, S; Rahimi, M; Rouzrokh, M, 2017)
"Hypospadias is a failure of urethral closure within the penis occurring in 1 in 125 boys at birth and is increasing in frequency."	( Pask, AJ; Renfree, MB; Tarulli, GA, 2020)
"Hypospadias is a common birth defect that might be caused by inadequate fusion of the urethral folds in the process of male external genital development."	( Feng, X; Gao, Y; Huang, E; Zhang, Y; Zhou, Y, 2021)
"Hypospadias is associated with vascular dysfunction and predisposes to hypertension and cardiovascular disease in adulthood."	( Ahmed, SF; Alimussina, M; Alves-Lopes, R; Amjad, SB; Brooksbank, K; Delles, C; Flett, M; Haddow, L; Lee, B; Lucas-Herald, AK; McCallum, L; Montezano, AC; O'Toole, S; Padmanabhan, S; Steven, M; Touyz, RM, 2022)
"Hypospadias is the ectopic opening of the urethra on the penis or scrotum."	( Acerini, CL; Bornman, R; Chevrier, J; Crause, M; Eskenazi, B; Obida, M; Rauch, S, 2022)
"Hypospadias is a common malformation of the penis."	( Amato, CM; Bereman, M; Fricke, A; Marella, S; McCoy, KA; Mogus, JP, 2022)
"Hypospadias is a common congenital abnormality typified by a proximally placed ectopic urethral meatus along the ventral surface of the penis."	( Badwal, S; Khanna, S; Shankar Raman, V; Vinu Balraam, KV, 2023)

Excerpt	Reference
"Most boys with hypospadias have no other signs of under-masculinization or congenital malformations."	( Karpman, E; Kurzrock, EA, 2004)
"Hypospadias have been associated with defects that alter androgen biosynthesis in the human fetal testis, specifically 5α-DHT."	( Chávez, B; Mares, L; Ramos, L; Vilchis, F, 2020)

Excerpt	Reference
"Hypospadias affects around 1/200 newborn males."	( Albrethsen, J; Cools, M; De Baere, E; Hiess, M; Hoebeke, P; Juul, A; Mahmoud, A; Riedl, S; Spinoit, AF; Springer, A; Tack, LJW; Tilleman, K; Tonnhofer, U; Van De Velde, J; Van Laecke, E; Verdin, H; Weninger, J, 2022)

Excerpt	Reference
"The sexual function of 82 patients treated for hypospadias was assessed."	( Kenawi, MM, 1975)
"For the treatment of hypospadias, a significant number of studies focus on penile reconstruction."	( Cong, R; Ji, C; Luan, J; Song, N; Wang, S; Wang, Y; Yao, L; Zhang, Q; Zhang, T; Zhou, R; Zhou, X, 2022)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	178 (28.25)	23.3326
1990's	62 (9.84)	12.5806
2000's	149 (23.65)	18.1394
2010's	176 (27.94)	28.8240
2020's	65 (10.32)	9.53

Drug	Relationship Strength	Studies	Trials
quinacrine	low	1	0
choline	low	1	0
salicylic acid	low	11	0
glycerol	low	1	0
nickel	low	1	0
nitrates	low	1	0
phthalic acid	low	5	0
sulfur dioxide	low	1	0
thiamine	low	1	0
urea	low	1	0
phenytoin	low	2	0
diatrizoic acid	low	1	0
aminoglutethimide	low	1	0
aspirin	low	1	0
atrazine	low	4	0
butylbenzyl phthalate	low	1	0
busulfan	low	1	0
caffeine	low	1	0
carbamazepine	low	1	0
clonidine	medium	3	3
dantrolene	low	1	0
dibutyl phthalate	low	26	0
dichlorodiphenyl dichloroethylene	low	8	0
ddt	low	6	0
dichlorvos	low	1	0
stallimycin	low	1	0
valproic acid	low	3	0
enflurane	low	1	0
erythrosine	low	1	0
ethosuximide	low	1	0
fluorouracil	low	1	0
flutamide	low	9	0
fasudil	low	1	0
halothane	medium	4	3
hydralazine	low	1	0
lidocaine	medium	2	2
indomethacin	low	1	0
isoflurane	medium	1	1
2-propanol	low	9	0
ketamine	medium	3	2
ketorolac	low	1	0
khellin	low	1	0
labetalol	low	1	0
loratadine	low	5	0
meclizine	low	2	0
meperidine	low	1	0
merbromin	low	1	0
midazolam	medium	1	1
nifedipine	low	1	0
nitroglycerin	medium	1	1
ondansetron	low	2	0
oxybutynin	low	1	0
oxyphenbutazone	medium	1	1
papaverine	low	1	0
pentobarbital	low	1	0
phenobarbital	low	1	0
procaine	low	1	0
propofol	medium	2	2
sevoflurane	medium	4	1
sulfamethoxazole	medium	1	1
sulforaphane	low	1	0
trimethadione	low	1	0
corticosterone	low	3	0
prednisolone	low	3	0
estriol	low	1	0
thymidine	low	1	0
hydroxyproline	low	1	0
spironolactone	low	1	0
trichlorfon	low	1	0
tetrahydrocortisol	low	2	0
estrone	low	4	0
androsterone	low	3	0
etiocholanolone	low	1	0
dehydroepiandrosterone	low	11	0
penicillin g	low	1	0
cyanides	low	1	0
sucrose	low	1	0
ethinyl estradiol	low	3	0
chlordan	low	1	0
testosterone propionate	low	2	0
methyltestosterone	low	1	0
bromodeoxyuridine	low	1	0
phenylephrine	low	1	0
methylene blue	low	1	0
leucine	low	1	0
androstenedione	low	11	0
methionine	low	1	0
desoxycorticosterone	low	2	0
cycloheximide	low	1	0
norethindrone	low	2	0
17-alpha-hydroxyprogesterone	low	3	0
mannitol	low	1	0
valine	low	1	0
arginine	low	1	0
cyclopropane	low	1	0
triamcinolone acetonide	low	1	0
isoprene	low	1	0
pantothenic acid	low	1	0
bisphenol a	low	5	0
propylparaben	low	1	0
2-methoxyethanol acetate	low	1	0
ethylene glycol monoethyl ether acetate	low	1	0
diethylhexyl phthalate	low	11	0
hexachlorobenzene	low	2	0
2,2',4,4'-tetrahydroxybenzophenone	low	1	0
pregnenolone	low	2	0
oxazoles	low	14	0
ethynodiol diacetate	low	1	0
testosterone enanthate	medium	9	3
hydantoins	low	2	0
medroxyprogesterone	low	1	0
dihydrotestosterone	medium	53	1
megestrol acetate	low	1	0
methoxyacetic acid	low	1	0
dehydroepiandrosterone sulfate	low	2	0
boldenone	low	2	0
d-alpha tocopherol	low	2	0
fluorescein	low	1	0
thioflavin t	low	1	0
phenoxyacetic acid	low	1	0
cyanoketone	low	1	0
mono-(2-ethylhexyl)phthalate	low	1	0
enbucrilate	low	2	0
octyl 2-cyanoacrylate	medium	2	1
mercury	low	1	0
chromium	low	2	0
zinc sulfate	low	1	0
chlorine	low	2	0
ozone	low	1	0
phenyl acetate	low	1	0
triamcinolone	low	2	0
transferrin	low	2	0
tramadol	medium	8	5
procymidone	low	4	0
substance p	low	1	0
vinclozolin	low	11	0
vecuronium bromide	medium	1	1
sufentanil	medium	1	1
desflurane	medium	1	1
atracurium	medium	1	1
colforsin	low	1	0
alfentanil	medium	1	1
finasteride	low	5	0
remifentanil	medium	1	1
testosterone undecanoate	medium	1	1
secoisolariciresinol	low	1	0
cephalosporin c	low	1	0
delphinidin	low	1	0
perfluorooctane sulfonic acid	low	1	0
nsc-172755	low	2	0
fibrinogen	low	1	0
17-alpha-hydroxypregnenolone	low	2	0
hydroxyflutamide	low	1	0
levobupivacaine	low	1	0
allotetrahydrocortisol	low	1	0
pregnanetriol	low	3	0
cobalt	low	1	0
vitamin b 6	low	1	0
l 656224	low	1	0
dexpanthenol	low	1	0
ropivacaine	medium	5	4
estradiol 3-benzoate	low	3	0
cortisone	low	2	0
allylestrenol	low	1	0
benzofurans	low	2	0
metribolone	low	4	0
povidone-iodine	low	3	0
7-dehydrocholesterol	low	1	0
inositol 3-phosphate	low	1	0
pentazocine	low	1	0
lignans	low	1	0
arachidonic acid	low	1	0
diethylstilbestrol	low	22	0
riboflavin	low	1	0
bromochloroacetic acid	low	4	0
diisononyl phthalate	low	2	0
glycosides	low	1	0
buprenorphine	low	1	0
leuprolide	low	1	0
enclomiphene	low	6	0
D-fructopyranose	low	1	0
succimer	low	1	0
tamoxifen	low	2	0
cystine	low	1	0
alpha-chymotrypsin	low	1	0
17-ketosteroids	low	18	0
dinoprostone	low	1	0
apigenin	medium	1	1
alprostadil	low	1	0
genistein	low	5	0
daidzein	low	1	0
phenylephrine hydrochloride	low	7	0
cyproterone	low	1	0
naloxone	low	1	0
topiramate	low	1	0
morphine	medium	9	5
dexmedetomidine	medium	1	1
lead	low	1	0
sulfur	low	1	0
heroin	medium	1	1
pregnanediol	low	1	0
beta-escin	low	2	0
chlorhexidine	low	1	0
abiraterone acetate	low	1	0
nystatin a1	low	1	0
losartan potassium	low	2	0
indocyanine green	medium	3	1
acid phosphatase	low	1	0
jaw	low	1	0
nad	low	1	0
menotropins	low	1	0
ro13-9904	low	1	0
sodium ethylxanthate	low	4	0
piperidines	medium	1	1
opium	low	1	0
oxytetracycline, anhydrous	low	1	0
epidermal growth factor	low	3	0
transforming growth factor beta	low	6	0
phytoestrogens	low	6	0
pyrethrins	low	1	0
rome	low	1	0
nonachlor	low	1	0
vitamin b 12	low	1	0
chondroitin sulfates	low	2	0
exudates	low	3	0
acyclovir	low	1	0
guanine	low	1	0
folic acid	medium	8	1

Protein Targets (1,751)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, Cruzipain	12	0	0	12
IDH1	25	0	0	25
DNA polymerase iota isoform a (long)	19	0	0	19
geminin	57	0	0	57
Sex hormone-binding globulin	0	2	18	20
acetylcholinesterase	25	0	0	25
pregnane X receptor	21	0	0	21
SMAD family member 2	32	0	0	32
SMAD family member 3	32	0	0	32
TDP1 protein	67	0	0	67
GLI family zinc finger 3	74	0	0	74
Microtubule-associated protein tau	26	0	0	26
AR protein	93	0	0	93
progesterone receptor	62	0	0	62
glucocorticoid receptor [Homo sapiens]	68	0	0	68
retinoic acid nuclear receptor alpha variant 1	78	0	0	78
retinoid X nuclear receptor alpha	64	0	0	64
estrogen-related nuclear receptor alpha	81	0	0	81
farnesoid X nuclear receptor	50	0	0	50
pregnane X nuclear receptor	75	0	0	75
estrogen nuclear receptor alpha	99	0	0	99
G	35	0	0	35
vitamin D (1,25- dihydroxyvitamin D3) receptor	49	0	0	49
arylsulfatase A	19	0	0	19
euchromatic histone-lysine N-methyltransferase 2	50	0	0	50
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	50	0	0	50
activating transcription factor 6	37	0	0	37
nuclear receptor subfamily 1, group I, member 2	9	0	0	9
chromobox protein homolog 1	41	0	0	41
nuclear factor erythroid 2-related factor 2 isoform 1	71	0	0	71
survival motor neuron protein isoform d	24	0	0	24
histone acetyltransferase KAT2A isoform 1	14	0	0	14
lamin isoform A-delta10	43	0	0	43
Voltage-dependent calcium channel gamma-2 subunit	43	0	0	43
Interferon beta	41	0	0	41
HLA class I histocompatibility antigen, B alpha chain	35	0	0	35
Glucocorticoid receptor	0	32	2	43
Glycine receptor subunit alpha-1	0	30	0	30
Corticosteroid-binding globulin	0	13	0	13
Adenosine receptor A3	0	16	1	17
Replicase polyprotein 1ab	0	5	2	7
Androgen receptor	0	42	1	44
Alpha-1B adrenergic receptor	0	20	1	21
Glutamate receptor 2	43	0	0	43
Glycine receptor subunit beta	0	30	0	30
Glycine receptor subunit alpha-2	0	30	0	30
Glycine receptor subunit alpha-3	0	30	0	30
Mitogen-activated protein kinase 3	0	1	1	2
Alpha-1A adrenergic receptor	0	20	2	22
Sodium-dependent dopamine transporter	0	18	0	18
TAR DNA-binding protein 43	19	0	0	19
Inositol hexakisphosphate kinase 1	35	0	0	35
cytochrome P450 2C9, partial	35	0	0	35
ATP-dependent phosphofructokinase	13	0	0	13
hypoxia-inducible factor 1 alpha subunit	30	0	0	30
RAR-related orphan receptor gamma	68	0	0	68
aldehyde dehydrogenase 1 family, member A1	43	0	0	43
peroxisome proliferator-activated receptor delta	50	0	0	50
v-jun sarcoma virus 17 oncogene homolog (avian)	38	0	0	38
Histone H2A.x	27	0	0	27
thyroid hormone receptor beta isoform a	31	0	0	31
heat shock protein beta-1	33	0	0	33
Luciferase	23	0	0	23
estrogen receptor 2 (ER beta)	46	0	0	46
nuclear receptor subfamily 1, group I, member 3	54	0	0	54
aryl hydrocarbon receptor	32	0	0	32
thyroid stimulating hormone receptor	36	0	0	36
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	39	0	0	39
thyroid hormone receptor beta isoform 2	61	0	0	61
histone deacetylase 9 isoform 3	9	0	0	9
Cellular tumor antigen p53	56	0	0	56
Polyphenol oxidase 1	0	1	0	1
Vitamin D3 receptor	0	0	0	1
Steroid 17-alpha-hydroxylase/17,20 lyase	0	3	0	3
Cytochrome P450 3A4	0	13	3	18
Androgen receptor	0	16	7	30
ATAD5 protein, partial	24	0	0	24
GLS protein	26	0	0	26
Smad3	16	0	0	16
thyroid stimulating hormone receptor	35	0	0	35
EWS/FLI fusion protein	22	0	0	22
peroxisome proliferator activated receptor gamma	49	0	0	49
peripheral myelin protein 22	28	0	0	28
cytochrome P450 3A4 isoform 1	38	0	0	38
Gamma-aminobutyric acid receptor subunit pi	38	8	2	48
ATP-binding cassette sub-family C member 3	0	35	0	35
Multidrug resistance-associated protein 4	0	36	0	40
Solute carrier family 22 member 6	0	6	0	7
Carbonic anhydrase 12	0	4	0	5
UDP-glucuronosyltransferase 1A9	0	0	0	3
Bile salt export pump	0	8	0	8
Bile salt export pump	0	57	0	57
Cytochrome P450 2B1	0	1	0	2
Cytochrome P450 1A1	0	0	0	1
Carbonic anhydrase 1	0	16	0	18
Carbonic anhydrase 2	0	17	3	22
Myoglobin	0	1	0	1
Cytochrome P450 1A1	0	4	1	6
Cytochrome P450 1A2	0	7	0	9
Prostaglandin G/H synthase 1	0	4	0	5
Carbonic anhydrase 3	0	3	0	3
Cytochrome P450 2D6	0	9	0	10
Cytochrome P450 2C9	0	12	0	12
Polyunsaturated fatty acid lipoxygenase ALOX15	0	10	0	10
Gamma-aminobutyric acid receptor subunit beta-1	38	8	2	48
Sulfotransferase 1A1	0	0	0	1
Gamma-aminobutyric acid receptor subunit delta	38	8	2	48
Gamma-aminobutyric acid receptor subunit gamma-2	38	8	2	48
UDP-glucuronosyltransferase 1-6	0	1	0	3
Gamma-aminobutyric acid receptor subunit alpha-5	38	8	2	48
Gamma-aminobutyric acid receptor subunit alpha-3	38	8	2	48
Arachidonate 5-lipoxygenase-activating protein	0	2	0	2
UDP-glucuronosyltransferase 1A1	0	3	0	5
Carbonic anhydrase 4	0	8	0	9
Prostaglandin G/H synthase 1	0	11	0	11
Carbonic anhydrase 6	0	4	0	5
Gamma-aminobutyric acid receptor subunit gamma-1	38	8	2	48
Gamma-aminobutyric acid receptor subunit alpha-2	38	8	2	48
Gamma-aminobutyric acid receptor subunit alpha-4	38	8	2	48
Gamma-aminobutyric acid receptor subunit gamma-3	38	8	2	48
Gamma-aminobutyric acid receptor subunit alpha-6	38	8	2	48
Carbonic anhydrase 5A, mitochondrial	0	4	1	6
Prostaglandin G/H synthase 2	0	8	2	12
Carbonic anhydrase 7	0	4	0	5
Nuclear receptor ROR-gamma	31	0	0	31
Cytochrome P450 2J2	0	8	0	8
Gamma-aminobutyric acid receptor subunit alpha-1	38	9	2	49
Gamma-aminobutyric acid receptor subunit beta-3	38	8	2	48
Gamma-aminobutyric acid receptor subunit beta-2	38	8	2	48
Carbonic anhydrase 9	0	5	1	7
GABA theta subunit	38	8	2	48
Canalicular multispecific organic anion transporter 1	0	34	0	34
Carbonic anhydrase 15	0	5	0	5
Carbonic anhydrase 13	0	3	0	4
Gamma-aminobutyric acid receptor subunit epsilon	38	8	2	48
Carbonic anhydrase 14	0	3	0	4
Carbonic anhydrase 5B, mitochondrial	0	3	0	4
toxin B	0	0	0	1
Chain E, Purine nucleoside phosphorylase	0	1	0	1
Chain A, HADH2 protein	17	0	0	17
Chain B, HADH2 protein	17	0	0	17
Chain A, ATP-DEPENDENT DNA HELICASE Q1	7	0	0	7
Chain A, Ferritin light chain	13	0	0	13
Thymidine kinase	0	2	0	3
thioredoxin reductase	31	0	0	31
phosphopantetheinyl transferase	16	0	0	16
Bloom syndrome protein isoform 1	17	0	0	17
hemoglobin subunit beta	3	0	0	3
atrial natriuretic peptide receptor 1 precursor	5	0	0	5
ubiquitin carboxyl-terminal hydrolase 2 isoform a	11	0	0	11
Solute carrier family 22 member 1	0	15	0	21
Purine nucleoside phosphorylase	0	3	0	3
Thymidine kinase, cytosolic	0	3	0	6
POU domain, class 2, transcription factor 2	0	0	0	1
Disintegrin and metalloproteinase domain-containing protein 17	7	0	0	7
Purine nucleoside phosphorylase	0	0	1	1
Solute carrier family 22 member 6	0	2	0	4
Thymidine kinase	0	1	0	1
Solute carrier family 22 member 8	0	3	0	5
Thymidine kinase	0	1	0	2
ATP-dependent translocase ABCB1	0	14	4	18
Mu-type opioid receptor	0	15	5	23
Kappa-type opioid receptor	0	8	1	10
Mu-type opioid receptor	0	11	2	13
Sigma non-opioid intracellular receptor 1	0	8	0	8
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	26	0	0	26
Thromboxane-A synthase	0	7	0	7
Prostaglandin E2 receptor EP3 subtype	0	3	0	3
Prostaglandin E2 receptor EP4 subtype	0	3	1	4
Prostaglandin E2 receptor EP1 subtype	0	3	0	3
Prostacyclin receptor	0	3	2	5
Nuclear receptor subfamily 4 group A member 2	0	0	2	2
Solute carrier organic anion transporter family member 2A1	0	0	0	3
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Prostaglandin E2 receptor EP2 subtype	0	3	1	4
Solute carrier organic anion transporter family member 2A1	0	0	0	2
Solute carrier organic anion transporter family member 2B1	0	1	0	1
Solute carrier organic anion transporter family member 3A1	0	0	0	1
cytochrome P450 family 3 subfamily A polypeptide 4	45	0	0	45
peripheral myelin protein 22 isoform 1	15	0	0	15
potassium voltage-gated channel subfamily H member 2 isoform d	16	0	0	16
transcriptional regulator ERG isoform 3	7	0	0	7
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	6	0	0	6
Sterol O-acyltransferase 1	0	1	0	1
Cholesterol side-chain cleavage enzyme, mitochondrial	0	1	0	1
Triosephosphate isomerase	0	2	0	2
Cholesterol side-chain cleavage enzyme, mitochondrial	0	1	0	1
Aromatase	0	12	0	19
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	1	1	2
Aromatase	0	1	1	2
Cytochrome P450 11B2, mitochondrial	0	1	0	1
Delta-type opioid receptor	0	11	1	14
interleukin 8	19	0	0	19
regulator of G-protein signaling 4	15	0	0	15
nonstructural protein 1	7	0	0	7
Caspase-7	6	0	0	6
caspase-3	6	0	0	6
importin subunit beta-1 isoform 1	8	0	0	8
mitogen-activated protein kinase 1	22	0	0	22
nuclear factor NF-kappa-B p105 subunit isoform 1	8	0	0	8
snurportin-1	8	0	0	8
GTP-binding nuclear protein Ran isoform 1	5	0	0	5
nuclear receptor ROR-gamma isoform 1	27	0	0	27
muscleblind-like protein 1 isoform 1	10	0	0	10
neuropeptide S receptor isoform A	8	0	0	8
Beta-glucuronidase	0	2	0	2
Cholinesterase	0	6	0	6
Gastrin/cholecystokinin type B receptor	0	1	0	2
Testosterone 17-beta-dehydrogenase 3	0	5	0	5
Alpha-synuclein	9	4	0	13
Chain A, retinol dehydratase	0	1	0	1
Glucose-6-phosphate 1-dehydrogenase	0	5	0	5
Solute carrier organic anion transporter family member 1A1	0	4	0	5
G-protein coupled bile acid receptor 1	0	0	5	5
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	18	0	0	18
Chain A, Putative fructose-1,6-bisphosphate aldolase	9	0	0	9
Chain A, 2-oxoglutarate Oxygenase	14	0	0	14
Chain A, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase	0	1	0	1
Chain B, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase	0	1	0	1
Chain A, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase	0	1	0	1
Chain B, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase	0	1	0	1
Chain A, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase	0	1	0	1
Chain B, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase	0	1	0	1
Chain A, Transthyretin	0	0	1	1
Chain A, Transthyretin	0	0	1	1
Chain A, Transthyretin	0	0	1	1
Chain A, Transthyretin	0	0	1	1
Chain B, Transthyretin	0	0	1	1
Chain A, Transthyretin	0	0	1	1
Chain B, Transthyretin	0	0	1	1
Chain A, Casein kinase II subunit alpha	0	1	0	1
Chain A, Casein kinase II subunit alpha	0	1	0	1
Chain A, Casein Kinase Ii Subunit Alpha	0	1	0	1
endonuclease IV	6	0	0	6
BRCA1	2	0	0	2
RGS12	1	0	0	1
15-lipoxygenase, partial	14	0	0	14
USP1 protein, partial	26	0	0	26
NFKB1 protein, partial	9	0	0	9
PPM1D protein	7	0	0	7
Thrombopoietin	9	0	0	9
apical membrane antigen 1, AMA1	5	0	0	5
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	20	0	0	20
cytochrome P450 2D6	27	0	0	27
Neuraminidase	0	4	0	4
67.9K protein	16	0	0	16
glucocerebrosidase	8	0	0	8
Parkin	8	0	0	8
pyruvate kinase	4	0	0	4
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	9	0	0	9
Replicase polyprotein 1ab	0	2	2	4
cytochrome P450 2D6 isoform 1	15	0	0	15
NPC intracellular cholesterol transporter 1 precursor	9	0	0	9
cellular tumor antigen p53 isoform a	16	0	0	16
cytochrome P450 2C19 precursor	13	0	0	13
cytochrome P450 2C9 precursor	13	0	0	13
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	16	0	0	16
nuclear factor erythroid 2-related factor 2 isoform 2	19	0	0	19
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	12	0	0	12
guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 1	1	0	0	1
glycogen synthase kinase-3 beta isoform 1	0	0	3	3
flap endonuclease 1	14	0	0	14
DNA polymerase eta isoform 1	3	0	0	3
DNA polymerase kappa isoform 1	14	0	0	14
M-phase phosphoprotein 8	9	0	0	9
pyruvate kinase PKM isoform b	4	0	0	4
Gamma-aminobutyric acid receptor subunit pi	0	2	0	2
Gamma-aminobutyric acid receptor subunit delta	0	2	0	2
Polyphenol oxidase 2	0	2	0	3
Aldo-keto reductase family 1 member B10	0	3	0	3
G2/mitotic-specific cyclin-B2	0	1	0	1
Poly [ADP-ribose] polymerase tankyrase-1	0	1	0	1
Lysozyme C-1	0	1	0	1
Cationic trypsin	0	1	0	1
Transthyretin	0	2	1	3
Estrogen receptor	0	28	7	37
Amyloid-beta precursor protein	1	4	0	5
Integrin beta-3	10	2	0	12
Myeloperoxidase	0	3	0	3
Cyclin-dependent kinase 1	0	2	1	3
Beta-glucuronidase	0	1	0	1
Aldo-keto reductase family 1 member B1	0	22	0	22
Seed linoleate 13S-lipoxygenase-1	0	3	0	5
Neutrophil elastase	0	3	0	3
Integrin alpha-IIb	10	2	0	12
Ornithine decarboxylase	4	0	0	4
Poly [ADP-ribose] polymerase 1	0	1	0	1
Replicase polyprotein 1a	0	1	2	3
Replicase polyprotein 1ab	0	1	2	3
Replicase polyprotein 1ab	0	3	2	5
Sialidase	0	2	0	2
Serine/threonine-protein kinase pim-1	0	1	1	3
Angiotensin-converting enzyme	0	5	0	5
Cystic fibrosis transmembrane conductance regulator	0	1	2	3
17-beta-hydroxysteroid dehydrogenase type 1	0	4	0	5
Pyruvate kinase PKM	0	1	0	1
G2/mitotic-specific cyclin-B1	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	4	1	5
Urease subunit alpha	0	3	0	3
Aldo-keto reductase family 1 member B1	0	6	0	6
G2/mitotic-specific cyclin-B	0	1	0	1
Mucin-1	0	1	0	1
Glycogen synthase kinase-3 beta	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	2	1	3
Gamma-aminobutyric acid receptor subunit gamma-2	0	3	2	5
Casein kinase II subunit alpha'	0	1	1	2
Amine oxidase [flavin-containing] A	0	8	0	8
Acetylcholinesterase	0	10	0	10
Amine oxidase [flavin-containing] B	0	7	0	7
Dipeptidyl peptidase 4	0	2	0	2
Proteasome subunit beta type-5	0	3	0	3
Gamma-aminobutyric acid receptor subunit beta-3	0	4	1	5
Substance-P receptor	0	6	0	6
Gamma-aminobutyric acid receptor subunit alpha-5	0	2	1	3
Multidrug resistance-associated protein 1	0	2	0	3
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	1	3
Mu-type opioid receptor	0	18	8	29
Receptor-type tyrosine-protein kinase FLT3	0	1	1	2
17-beta-hydroxysteroid dehydrogenase type 2	0	2	0	2
Acetylcholinesterase	0	2	0	2
Peroxisome proliferator-activated receptor gamma	0	0	1	1
Delta-type opioid receptor	0	15	3	21
Kappa-type opioid receptor	0	19	4	26
Homeobox protein Nkx-2.5	0	1	0	1
Tyrosine-protein kinase SYK	0	2	2	4
Histamine H2 receptor	16	0	0	16
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	2	4
Gamma-aminobutyric acid receptor subunit beta-2	0	2	2	4
Xanthine dehydrogenase/oxidase	0	5	0	5
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	1	3
Glycogen synthase kinase-3 alpha	0	2	1	3
Glycogen synthase kinase-3 beta	0	2	1	3
Estrogen receptor	0	0	2	2
Death-associated protein kinase 1	0	2	0	2
Mitogen-activated protein kinase 10	0	2	1	3
Beta-secretase 1	0	1	0	2
Casein kinase II subunit beta	0	1	0	1
Casein kinase II subunit alpha	0	2	0	2
Urease subunit beta	0	3	0	3
Gamma-aminobutyric acid receptor subunit epsilon	0	2	0	2
Lactoperoxidase	0	2	0	2
Xanthine dehydrogenase/oxidase	0	3	0	3
MO15-related protein kinase Pfmrk	0	3	0	3
Inositol monophosphatase 1	14	0	0	14
Cyclin-dependent kinase 6	0	1	1	2
Cyclin-dependent-like kinase 5	0	1	1	2
Cyclin homolog	0	1	0	1
Transcription factor GATA-4	0	1	0	1
Cyclin-dependent kinase 5 activator 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	2	1	3
Mitogen-activated protein kinase 14	0	3	1	4
Cytochrome P450 1B1	0	4	0	4
Carbonic anhydrase 3	0	1	0	1
Substance-K receptor	0	3	0	3
Reverse transcriptase/RNaseH	0	1	0	1
Integrase	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-1	0	2	0	2
Casein kinase II subunit alpha 3	0	1	0	1
Inositol polyphosphate multikinase	0	1	0	1
G2/mitotic-specific cyclin-B3	0	1	0	1
Estrogen receptor beta	0	16	7	24
Enoyl-acyl-carrier protein reductase	0	1	0	1
Aurora kinase B	0	1	1	2
NACHT, LRR and PYD domains-containing protein 3	0	1	0	1
ATPase family AAA domain-containing protein 5	25	0	0	25
Ataxin-2	30	0	0	30
Gamma-aminobutyric acid receptor subunit gamma-3	0	2	0	2
Myocilin	0	0	1	1
Cyclin-dependent kinase 1	0	1	0	1
Prenyltransferase homolog	0	0	0	3
Poly [ADP-ribose] polymerase tankyrase-2	0	1	0	1
MAP kinase-interacting serine/threonine-protein kinase 2	0	1	0	1
Carboxylic ester hydrolase	0	2	0	2
NADPH oxidase 4	0	1	0	1
Dipeptidyl peptidase 3	0	2	0	2
Estrogen receptor beta	0	0	2	2
Inositol hexakisphosphate kinase 2	0	1	0	1
Short transient receptor potential channel 5	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	2	0	2
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	6	0	6
Sialidase-2	0	2	0	2
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	2	0	0	2
Chain A, ADIPOCYTE LIPID-BINDING PROTEIN	0	0	1	1
Chain A, SERUM ALBUMIN	0	0	1	1
Chain A, SERUM ALBUMIN	0	0	1	1
Chain A, Beta-lactamase	19	0	0	19
thioredoxin glutathione reductase	6	0	0	6
vitamin D3 receptor isoform VDRA	13	0	0	13
lethal(3)malignant brain tumor-like protein 1 isoform I	6	0	0	6
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	4	0	0	4
caspase-1 isoform alpha precursor	2	0	0	2
Fatty-acid amide hydrolase 1	0	2	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15B	6	1	0	7
Prostaglandin G/H synthase 1	0	2	0	4
Trypsin	0	1	0	1
Coagulation factor VII	0	1	0	1
60 kDa chaperonin	0	2	0	2
60 kDa heat shock protein, mitochondrial	0	2	0	2
Tissue factor	0	2	0	2
Fatty acid-binding protein, adipocyte	0	1	1	2
10 kDa heat shock protein, mitochondrial	0	2	0	2
Calmodulin	0	0	0	1
Prostaglandin G/H synthase 2	0	3	0	4
Fatty acid-binding protein 5	0	1	0	1
Fatty acid-binding protein 5	0	0	1	1
Thiosulfate sulfurtransferase	0	2	0	2
Lanosterol 14-alpha demethylase	0	2	0	2
60 kDa chaperonin	0	2	0	2
10 kDa chaperonin	0	2	0	2
Solute carrier organic anion transporter family member 1B3	0	6	0	7
Cytosolic phospholipase A2 gamma	0	2	0	2
Transient receptor potential cation channel subfamily V member 2	0	1	0	1
Solute carrier organic anion transporter family member 1B1	0	6	0	7
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
alpha-galactosidase	4	0	0	4
muscarinic acetylcholine receptor M1	17	0	0	17
lethal factor (plasmid)	16	0	0	16
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	2	0	3
Nitric oxide synthase, inducible	0	0	1	3
Cationic amino acid transporter 3	0	1	0	1
Chain A, Phospholipase A2 isoform 3	0	0	1	1
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
hypothetical protein, conserved	5	0	0	5
Rac1 protein	0	0	1	1
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
Prostaglandin-H2 D-isomerase	0	2	0	2
Prostaglandin G/H synthase 2	0	2	0	3
Epidermal growth factor receptor	0	8	1	9
Fatty acid-binding protein, liver	0	3	0	3
Glutathione hydrolase 1 proenzyme	0	1	0	1
Adenosine receptor A1	0	4	0	5
Adenosine receptor A2a	0	6	1	9
Urotensin-2 receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Ras-related protein Rab-2A	0	0	1	1
Rho-associated protein kinase 2	0	3	0	3
Nicotinate phosphoribosyltransferase	0	4	0	4
Solute carrier family 22 member 20	0	3	0	3
Solute carrier family 22 member 6	0	3	0	3
Sigma non-opioid intracellular receptor 1	0	17	1	18
Sigma non-opioid intracellular receptor 1	0	3	1	4
NPYLR7B	0	0	3	3
Amine oxidase [flavin-containing] A	0	1	1	2
Small conductance calcium-activated potassium channel protein 3	0	1	1	2
glp-1 receptor, partial	25	0	0	25
galanin receptor type 3	0	1	0	1
ORF73	0	0	2	2
Chain A, Estrogen-related receptor gamma	0	0	1	1
Chain A, Estrogen-related receptor gamma	0	0	1	1
Chain A, Estrogen-related receptor gamma	0	0	1	1
Chain A, Estrogen-related receptor gamma	0	0	1	1
GALC protein	11	0	0	11
caspase 7, apoptosis-related cysteine protease	11	0	0	11
caspase-3	11	0	0	11
GTPase KRas	0	0	1	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	2	0	2
Sodium-dependent noradrenaline transporter	0	20	1	21
Sodium-dependent serotonin transporter	0	20	0	20
5-hydroxytryptamine receptor 6	0	12	1	14
Estrogen-related receptor gamma	0	2	1	3
GTP-binding protein Rheb	0	0	1	1
bromodomain adjacent to zinc finger domain 2B	16	0	0	16
Nuclear hormone receptor family member daf-12	0	0	1	1
serine/threonine-protein kinase mTOR isoform 1	8	0	0	8
oxysterols receptor LXR-beta isoform 1	0	0	1	1
urokinase-type plasminogen activator precursor	14	0	0	14
plasminogen precursor	14	0	0	14
urokinase plasminogen activator surface receptor precursor	14	0	0	14
Thymidine phosphorylase	0	0	0	2
Thymidylate kinase	0	2	0	2
Spike glycoprotein	22	0	2	24
Thymidine kinase	0	0	0	2
Thymidylate kinase	0	2	0	2
Potassium channel subfamily K member 3	0	3	0	3
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 2	0	1	3	4
Potassium channel subfamily K member 9	0	1	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	14	0	0	14
Matrix metalloproteinase-9	0	2	0	2
Rap guanine nucleotide exchange factor 4	4	0	0	4
Chain A, Glycogen Phosphorylase	0	1	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Chitinase	0	1	0	1
DNA polymerase beta	7	0	0	7
Glycogen phosphorylase, muscle form	0	1	0	1
Renin	0	1	0	1
Glycogen phosphorylase, liver form	0	1	0	1
Glycogen phosphorylase, muscle form	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	2	0	2
Adenosine receptor A3	0	1	0	1
Adenosine receptor A2a	0	12	2	15
Adenosine receptor A2b	0	1	0	2
Adenosine receptor A2b	0	2	1	4
Adenosine receptor A1	0	10	1	13
Vasopressin V2 receptor	0	0	0	1
Serine/threonine-protein kinase mTOR	0	1	0	1
Adenosine receptor A2a	0	1	0	1
Adenosine receptor A1	0	1	0	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	1	0	1
DNA-dependent protein kinase catalytic subunit	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Adenylate cyclase type 1	0	1	1	3
Chitotriosidase-1	0	1	0	1
Serine-protein kinase ATM	0	1	0	1
Serine/threonine-protein kinase ATR	0	1	0	1
Adenosine receptor A2b	0	1	0	2
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	1	2	3
Endochitinase B1	0	1	0	1
Muscarinic acetylcholine receptor	0	1	1	3
Phosphodiesterase	0	1	0	1
Guanine deaminase	0	1	0	2
Vpr	6	0	0	6
Albumin	0	0	1	1
Major prion protein	0	0	2	2
Sodium channel protein type 1 subunit alpha	0	2	0	2
Sodium channel protein type 2 subunit alpha	0	4	0	4
Sodium channel protein type 3 subunit alpha	0	2	0	2
UDP-glucuronosyltransferase 2B7	0	2	0	6
Cytochrome P450 2B6	0	2	1	3
Sodium channel protein type 4 subunit alpha	0	5	0	7
Potassium voltage-gated channel subfamily H member 2	0	21	0	21
Sodium channel protein type 9 subunit alpha	0	5	0	5
Frizzled-8	0	0	1	1
P2X purinoceptor 4	0	1	0	1
thyrotropin-releasing hormone receptor	7	0	0	7
Caspase-2	0	0	1	1
Peroxisome proliferator-activated receptor alpha	2	0	0	2
Chain A, BCL-2-RELATED PROTEIN A1	0	0	1	1
acid sphingomyelinase	3	0	0	3
PAX8	0	0	0	1
PINK1	2	0	0	2
heat shock protein 90	0	0	1	1
calcineurin A1, putative	0	0	1	1
hepatocyte nuclear factor 4-alpha isoform 2	0	2	0	2
perilipin-5	0	3	0	3
perilipin-1	0	3	0	3
huntingtin isoform 2	5	0	0	5
ubiquitin-conjugating enzyme E2 N	0	3	0	3
protein AF-9 isoform a	0	0	0	3
melanocortin receptor 4	0	1	0	1
CAAX prenyl protease	0	0	0	1
bcl-2-related protein A1	0	1	0	1
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	3	0	3
glycogen synthase kinase-3 alpha	0	0	0	1
hexokinase HKDC1	0	1	0	1
DNA repair protein RAD52 homolog isoform a	0	0	0	2
bcl-2-like protein 11 isoform 1	0	0	1	1
Synaptojanin-2	0	1	0	1
Solute carrier family 22 member 2	0	5	0	7
Synaptojanin-1	0	1	0	1
Solute carrier family 22 member 3	0	5	0	5
Glutathione reductase, mitochondrial	0	5	0	7
72 kDa type IV collagenase	0	1	0	1
Trypanothione reductase	0	3	0	3
Peroxisomal N(1)-acetyl-spermine/spermidine oxidase	0	1	0	1
Multidrug and toxin extrusion protein 2	0	4	0	4
Multidrug and toxin extrusion protein 1	0	9	0	9
Spermine oxidase	0	1	0	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Putative Glycine Betaine-binding Abc Transporter Protein	0	0	1	1
Chain A, PUTATIVE GLYCINE BETAINE-BINDING ABC TRANSPORTER PROTEIN	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Choline-binding protein	0	0	1	1
Solute carrier family 22 member 1	0	1	0	2
Solute carrier family 22 member 2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-3	0	3	2	6
Neuronal acetylcholine receptor subunit alpha-4	3	6	3	13
Neuronal acetylcholine receptor subunit alpha-2	0	3	2	6
Neuronal acetylcholine receptor subunit beta-2	3	5	3	12
Neuronal acetylcholine receptor subunit beta-3	0	3	2	6
Neuronal acetylcholine receptor subunit beta-4	0	3	2	6
Neuronal acetylcholine receptor subunit alpha-5	0	3	2	6
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Choline O-acetyltransferase	0	0	0	1
Neuronal acetylcholine receptor subunit alpha-6	0	3	2	6
Neuronal acetylcholine receptor subunit alpha-9	0	3	2	6
Neuronal acetylcholine receptor subunit alpha-7	0	5	2	8
Solute carrier family 22 member 1	0	6	0	7
High affinity choline transporter 1	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-10	0	3	2	6
Solute carrier family 22 member 2	0	6	0	7
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain B, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain A, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain B, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Beta-lactamase	0	1	0	1
Proto-oncogene tyrosine-protein kinase Src	0	2	1	3
3-dehydroquinate dehydratase	0	0	1	1
ATP-citrate synthase	0	0	0	1
Ribonuclease T	0	0	0	1
Cell death-related nuclease 4	0	0	0	1
3-dehydroquinate dehydratase	0	0	1	1
Prolyl 4-hydroxylase	0	1	0	1
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
Beta-1 adrenergic receptor	0	1	3	5
Alpha-1B adrenergic receptor	0	0	3	3
Membrane primary amine oxidase	0	1	0	1
5-hydroxytryptamine receptor 3A	0	0	2	2
5-hydroxytryptamine receptor 1A	0	4	0	4
Alpha-2A adrenergic receptor	0	13	6	20
Alpha-2B adrenergic receptor	0	11	2	14
Alpha-1A adrenergic receptor	0	1	3	4
Alpha-2C adrenergic receptor	0	13	5	19
D	0	2	0	2
D(3) dopamine receptor	0	4	0	4
5-hydroxytryptamine receptor 1A	0	10	1	12
Alpha-2B adrenergic receptor	0	4	2	6
Alpha-2C adrenergic receptor	0	4	2	6
Alpha-2A adrenergic receptor	0	5	2	7
Alpha-1D adrenergic receptor	0	6	1	7
Alpha-1D adrenergic receptor	0	11	3	15
D(1B) dopamine receptor	0	2	0	2
5-hydroxytryptamine receptor 1B	0	9	0	9
Alpha-2B adrenergic receptor	0	0	0	2
D(4) dopamine receptor	0	2	0	2
Alpha-1A adrenergic receptor	0	3	5	9
Alpha-1B adrenergic receptor	0	2	4	7
5-hydroxytryptamine receptor 7	0	4	0	4
D(2) dopamine receptor	0	3	1	4
Alpha-2C adrenergic receptor	0	0	0	2
Alpha-2A adrenergic receptor	0	0	0	2
Alpha-2A adrenergic receptor	0	1	0	1
Nischarin	0	2	0	2
Nischarin	0	2	0	2
Cytochrome P450 2D1	0	1	0	1
Cytochrome P450 2D26	0	1	0	1
Cytochrome P450 2D3	0	1	0	1
Kappa-type opioid receptor	0	5	1	8
Mu-type opioid receptor	0	6	1	10
Cytochrome P450 2D4	0	1	0	1
Mas-related G-protein coupled receptor member X2	0	0	3	3
nuclear receptor subfamily 0 group B member 1	0	1	0	1
steroidogenic factor 1	0	1	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	7	0	0	7
relaxin receptor 1 isoform 1	2	0	0	2
relaxin receptor 2 isoform 1	1	0	0	1
Nuclear receptor subfamily 1 group I member 2	0	1	3	4
Rap guanine nucleotide exchange factor 3	7	0	0	7
Solute carrier family 2, facilitated glucose transporter member 1	0	2	1	3
Adenylate cyclase type 2	0	0	1	1
Adenylate cyclase type 8	0	0	1	1
Relaxin receptor 1	0	0	1	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Solute carrier family 22 member 3	0	2	0	2
Mineralocorticoid receptor	0	6	2	9
C-8 sterol isomerase	0	3	0	3
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	4	1	5
dopamine D1 receptor	3	0	0	3
Potassium voltage-gated channel subfamily A member 1	0	1	1	2
Cytochrome P450 2A6	0	4	1	5
Cytochrome P450 2A5	0	2	0	2
Carbonic anhydrase	0	3	0	3
Fumarate hydratase	12	0	0	12
polyprotein	12	0	0	12
P53	2	0	0	2
RPL19A	0	0	1	1
Spike glycoprotein	0	0	2	2
ras-related protein Rab-9A	12	0	0	12
heat shock protein HSP 90-alpha isoform 2	0	0	0	1
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
COUP transcription factor 2 isoform a	0	1	0	1
Transmembrane protease serine 2	0	0	2	2
Glucose transporter	0	1	0	1
Hexose transporter 1	0	1	0	1
Procathepsin L	0	1	2	3
Polyunsaturated fatty acid 5-lipoxygenase	0	6	0	6
Eukaryotic initiation factor 4A-I	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	2	0	2
Peptidyl-prolyl cis-trans isomerase FKBP3	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP4	0	1	0	1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	0	1	0	1
Hypoxia-inducible factor 1-alpha	0	1	0	1
Endothelial PAS domain-containing protein 1	0	1	0	1
Angiotensin-converting enzyme 2	0	0	2	2
Peptidyl-prolyl cis-trans isomerase FKBP14	0	1	0	1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4	0	1	0	1
heat shock protein 90, putative	0	0	0	1
Glutathione S-transferase P	0	1	0	1
Alpha-tocopherol transfer protein	0	0	1	1
rac GTPase-activating protein 1 isoform a	0	1	0	1
Aldehyde dehydrogenase, mitochondrial	0	1	0	1
Tyrosinase	0	2	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15	0	2	0	2
Polyunsaturated fatty acid lipoxygenase ALOX12	0	1	0	1
UDP-glucuronosyltransferase 1A4	0	1	0	3
Transporter	0	1	0	1
Beta-hydroxyacyl-ACP dehydratase precursor (Fatty acid synthesis protein)	0	2	0	2
Beta-glucuronidase	0	1	0	1
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
NPC1-like intracellular cholesterol transporter 1	0	0	1	1
Solute carrier organic anion transporter family member 1A4	0	0	0	1
Solute carrier organic anion transporter family member 1A5	0	0	0	2
Steryl-sulfatase	0	1	0	2
Solute carrier organic anion transporter family member 1A2	0	0	0	1
Solute carrier organic anion transporter family member 1A3	0	2	0	3
ATP-binding cassette sub-family C member 11	0	0	0	1
Solute carrier family 22 member 11	0	0	0	2
Solute carrier organic anion transporter family member 1A1	0	0	0	1
Solute carrier organic anion transporter family member 1B2	0	0	0	2
Vascular endothelial growth factor receptor 2	0	2	0	2
Lactoylglutathione lyase	0	2	0	2
Histone acetyltransferase p300	0	1	0	1
CREB-binding protein	1	1	0	2
Cathepsin B	0	1	0	1
Cathepsin B	0	1	0	1
serine-protein kinase ATM isoform a	3	0	0	3
Acetylcholinesterase	0	1	0	1
serine/threonine-protein kinase PLK1	4	0	0	4
high affinity choline transporter 1 isoform a	0	1	0	1
5-hydroxytryptamine receptor 4	0	14	0	14
Tyrosine-protein kinase Fyn	0	5	1	6
Beta-1 adrenergic receptor	0	8	3	11
Muscarinic acetylcholine receptor M1	0	11	1	14
D(2) dopamine receptor	0	7	1	8
Muscarinic acetylcholine receptor M3	0	11	1	13
Substance-K receptor	0	8	0	8
D(1A) dopamine receptor	0	5	1	6
5-hydroxytryptamine receptor 2A	0	13	1	14
5-hydroxytryptamine receptor 2C	0	14	1	15
D(3) dopamine receptor	0	11	0	11
Vasopressin V1a receptor	0	3	1	4
5-hydroxytryptamine receptor 2B	0	22	1	23
Aldehyde oxidase	0	4	0	4
UDP-glucose 4-epimerase	0	1	0	1
Cysteinyl leukotriene receptor 1	0	2	0	2
Chain A, Sex Hormone-Binding Globulin	0	0	1	1
Plasma kallikrein	0	1	0	1
Progesterone receptor	0	1	0	1
Progesterone receptor	0	10	4	15
Glucocorticoid receptor	0	2	1	3
Sex hormone-binding globulin	0	2	0	2
Androgen receptor	0	2	2	4
Mineralocorticoid receptor	0	1	0	1
Angiotensin-converting enzyme	0	0	1	1
Cannabinoid receptor 2	0	1	0	1
Neuropeptide FF receptor 2	0	0	0	2
ALK tyrosine kinase receptor	0	1	0	1
prostaglandin E2 receptor EP2 subtype	1	0	0	1
Prostaglandin E2 receptor EP1 subtype	0	2	1	3
Prostaglandin E2 receptor EP4 subtype	0	2	1	3
Prostaglandin F2-alpha receptor	0	0	1	1
Prostaglandin E2 receptor EP4 subtype	0	1	1	2
Prostaglandin E2 receptor EP3 subtype	0	2	1	3
Prostaglandin E2 receptor EP2 subtype	0	2	1	3
Solute carrier family 22 member 7	0	0	0	3
Prostaglandin E2 receptor EP2 subtype	0	1	1	2
Solute carrier family 22 member 7	0	0	0	1
Solute carrier family 22 member 7	0	0	0	1
chaperonin-containing TCP-1 beta subunit homolog	4	0	0	4
Receptor tyrosine-protein kinase erbB-2	0	2	0	2
Muscarinic acetylcholine receptor M2	0	9	2	13
Muscarinic acetylcholine receptor M4	0	8	0	9
Muscarinic acetylcholine receptor M5	0	8	0	9
Beta-3 adrenergic receptor	0	6	3	9
Genome polyprotein	0	1	1	2
eyes absent homolog 2 isoform a	2	0	0	2
Flavin reductase (NADPH)	0	0	1	1
large T antigen	0	1	0	1
streptokinase A precursor	0	0	3	3
Estrogen receptor	0	0	3	4
Estrogen receptor beta	0	0	3	4
Lanosterol 14-alpha demethylase	0	0	1	1
Olfactory receptor 51E2	0	0	3	3
UDP-glucuronosyltransferase 1A10	0	0	0	1
hexokinase-4 isoform 1	3	0	0	3
glucokinase regulatory protein	3	0	0	3
Ghrelin O-acyltransferase	0	1	0	1
lysosomal alpha-glucosidase preproprotein	4	0	0	4
3-oxo-5-alpha-steroid 4-dehydrogenase 1	0	4	0	4
Sulfotransferase 1A1	0	2	1	4
Nuclear receptor subfamily 1 group I member 3	0	1	0	1
Voltage-dependent T-type calcium channel subunit alpha-1I	0	1	0	1
Chain H, IGG1-KAPPA DB3 FAB (HEAVY CHAIN)	0	1	0	1
Chain L, IGG1-KAPPA DB3 FAB (LIGHT CHAIN)	0	1	0	1
Chain H, IGG1-KAPPA DB3 FAB (HEAVY CHAIN)	0	1	0	1
Chain L, IGG1-KAPPA DB3 FAB (LIGHT CHAIN)	0	1	0	1
Chain H, IGG1-KAPPA DB3 FAB (HEAVY CHAIN)	0	1	0	1
Chain L, IGG1-KAPPA DB3 FAB (LIGHT CHAIN)	0	1	0	1
ClpP	1	0	0	1
Guanine nucleotide-binding protein G	7	0	0	7
Chain E, cAMP-dependent protein kinase, alpha-catalytic subunit	0	1	0	1
Chain I, cAMP-dependent protein kinase inhibitor, alpha form	0	1	0	1
Chain B, Rho-associated protein kinase 1	0	1	0	1
Chain A, Rho-associated protein kinase 1	0	1	0	1
Chain A, Rho-associated protein kinase 1	0	1	0	1
Chain A, cAMP-dependent protein kinase, alpha-catalytic subunit	0	1	0	1
Chain A, cAMP-dependent protein kinase, alpha-catalytic subunit	0	1	0	1
Chain A, cAMP-dependent protein kinase, alpha-catalytic subunit	0	1	0	1
Chain I, cAMP-dependent protein kinase inhibitor alpha	0	1	0	1
Chain A, cAMP-dependent protein kinase, alpha-catalytic subunit	0	1	0	1
Chain A, cAMP-dependent protein kinase, alpha-catalytic subunit	0	1	0	1
Chain I, cAMP-dependent protein kinase inhibitor alpha	0	1	0	1
Chain A, Rho-associated protein kinase 1	0	1	0	1
cAMP-dependent protein kinase catalytic subunit alpha isoform Calpha1	0	0	0	1
serine/threonine-protein kinase 33 isoform a	0	0	0	1
Bone morphogenetic protein receptor type-1B	0	0	1	1
Cell division cycle 7-related protein kinase	0	0	1	1
Serine/threonine-protein kinase PLK4	0	0	1	1
ATP-dependent RNA helicase DDX3X	0	0	1	1
Pyridoxal kinase	0	0	1	1
Citron Rho-interacting kinase	0	0	1	1
Serine/threonine-protein kinase Chk1	0	0	1	1
Aurora kinase A	0	0	1	1
Cyclin-G-associated kinase	0	0	1	1
Ephrin type-B receptor 6	0	0	1	1
Peroxisomal acyl-coenzyme A oxidase 3	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 2	0	0	1	1
Mitotic checkpoint serine/threonine-protein kinase BUB1	0	0	1	1
Dynamin-like 120 kDa protein, mitochondrial	0	0	1	1
Eukaryotic translation initiation factor 5B	0	0	1	1
Rho-associated protein kinase 2	0	2	1	3
Serine/threonine-protein kinase ULK1	0	0	1	1
Serine/threonine-protein kinase/endoribonuclease IRE1	0	0	1	1
Ribosomal protein S6 kinase alpha-5	0	1	1	2
U5 small nuclear ribonucleoprotein 200 kDa helicase	0	0	1	1
Ribosomal protein S6 kinase alpha-4	0	0	1	1
Serine/threonine-protein kinase 16	0	0	1	1
Serine/threonine-protein kinase 10	0	0	1	1
Serine/threonine-protein kinase D3	0	1	1	2
Structural maintenance of chromosomes protein 2	0	0	1	1
Mitogen-activated protein kinase kinase kinase 6	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 4	0	0	1	1
Serine/threonine-protein kinase LATS1	0	0	1	1
Serine/threonine-protein kinase PAK 4	0	0	1	1
cAMP-dependent protein kinase catalytic subunit alpha	0	1	0	1
Tyrosine-protein kinase ABL1	0	1	1	2
High affinity nerve growth factor receptor	0	0	1	1
Guanine nucleotide-binding protein G(i) subunit alpha-2	0	0	1	1
cAMP-dependent protein kinase catalytic subunit alpha	0	1	0	1
ADP/ATP translocase 2	0	0	1	1
Protein kinase C beta type	0	1	1	2
Insulin receptor	0	0	1	1
Tyrosine-protein kinase Lck	0	1	2	3
Glycogen phosphorylase, liver form	0	0	1	1
Tyrosine-protein kinase Fes/Fps	0	0	1	1
Adenine phosphoribosyltransferase	0	0	1	1
Tyrosine-protein kinase Yes	0	0	1	1
Tyrosine-protein kinase Lyn	0	0	1	1
Proto-oncogene tyrosine-protein kinase receptor Ret	0	0	1	1
Insulin-like growth factor 1 receptor	0	0	1	1
Signal recognition particle receptor subunit alpha	0	0	1	1
Cytochrome c1, heme protein, mitochondrial	0	0	1	1
Hepatocyte growth factor receptor	0	0	1	1
Tyrosine-protein kinase HCK	0	0	1	1
Platelet-derived growth factor receptor beta	0	0	1	1
Tyrosine-protein kinase Fgr	0	0	1	1
Serine/threonine-protein kinase A-Raf	0	0	1	1
Glycogen phosphorylase, brain form	0	0	1	1
Breakpoint cluster region protein	0	0	1	1
Fibroblast growth factor receptor 1	0	0	1	1
DNA topoisomerase 2-alpha	0	0	1	1
Cyclin-dependent kinase 4	0	1	1	2
ADP/ATP translocase 3	0	0	1	1
Inosine-5'-monophosphate dehydrogenase 2	0	0	1	1
C-C motif chemokine 2	0	1	0	1
cAMP-dependent protein kinase type II-alpha regulatory subunit	0	0	1	1
Serine/threonine-protein kinase B-raf	0	0	1	1
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	0	0	1	1
Tyrosine-protein kinase Fer	0	0	1	1
Protein kinase C alpha type	0	2	1	3
cAMP-dependent protein kinase catalytic subunit alpha	0	3	1	4
General transcription and DNA repair factor IIH helicase subunit XPD	0	0	1	1
Ras-related protein Rab-6A	0	0	1	1
Ephrin type-A receptor 1	0	0	1	1
Multifunctional protein ADE2	0	0	1	1
cAMP-dependent protein kinase catalytic subunit gamma	0	2	1	3
cAMP-dependent protein kinase catalytic subunit beta	0	2	1	3
Ferrochelatase, mitochondrial	0	0	1	1
Ribosomal protein S6 kinase beta-1	0	0	1	1
Tyrosine-protein kinase JAK1	0	0	1	1
Cyclin-dependent kinase 2	0	0	1	1
Beta-adrenergic receptor kinase 1	0	0	1	1
Probable ATP-dependent RNA helicase DDX6	0	0	1	1
MAP/microtubule affinity-regulating kinase 3	0	0	1	1
Deoxycytidine kinase	0	0	1	1
Mitogen-activated protein kinase 1	0	0	1	1
Ephrin type-A receptor 2	0	0	1	1
Ephrin type-B receptor 2	0	0	1	1
Non-receptor tyrosine-protein kinase TYK2	0	0	1	1
UMP-CMP kinase	0	0	1	1
Phosphatidylethanolamine-binding protein 1	0	0	1	1
Wee1-like protein kinase	0	0	1	1
Heme oxygenase 2	0	0	1	1
S-adenosylmethionine synthase isoform type-2	0	0	1	1
DnaJ homolog subfamily A member 1	0	0	1	1
RAC-alpha serine/threonine-protein kinase	0	1	1	2
RAC-beta serine/threonine-protein kinase	0	0	1	1
Dual specificity protein kinase TTK	0	0	1	1
DNA replication licensing factor MCM4	0	0	1	1
Myosin-10	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 2	0	0	1	1
Bone morphogenetic protein receptor type-1A	0	0	1	1
Activin receptor type-1B	0	0	1	1
TGF-beta receptor type-1	0	0	1	1
TGF-beta receptor type-2	0	0	1	1
Electron transfer flavoprotein subunit beta	0	0	1	1
Tyrosine-protein kinase CSK	0	1	1	2
Glycine--tRNA ligase	0	0	1	1
C-C chemokine receptor type 2	0	3	0	3
Protein kinase C iota type	0	1	1	2
Exosome RNA helicase MTR4	0	0	1	1
Tyrosine-protein kinase Tec	0	0	1	1
Tyrosine-protein kinase ABL2	0	1	1	2
Tyrosine-protein kinase FRK	0	0	1	1
G protein-coupled receptor kinase 6	0	0	1	1
26S proteasome regulatory subunit 6B	0	0	1	1
Mitogen-activated protein kinase 8	0	0	1	1
Mitogen-activated protein kinase 9	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 3	0	0	1	1
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	0	0	1	1
Casein kinase I isoform alpha	0	0	1	1
Casein kinase I isoform delta	0	0	1	1
MAP kinase-activated protein kinase 2	0	0	1	1
Elongation factor Tu, mitochondrial	0	0	1	1
Choline-phosphate cytidylyltransferase A	0	0	1	1
Cysteine--tRNA ligase, cytoplasmic	0	0	1	1
Casein kinase I isoform epsilon	0	0	1	1
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	0	0	1	1
Dual specificity protein kinase CLK1	0	0	1	1
Dual specificity protein kinase CLK2	0	0	1	1
Dual specificity protein kinase CLK3	0	0	1	1
Cyclin-dependent kinase 7	0	0	1	1
Cyclin-dependent kinase 9	0	0	1	1
Ras-related protein Rab-27A	0	0	1	1
Interleukin-1 receptor-associated kinase 1	0	0	1	1
Ribosomal protein S6 kinase alpha-3	0	0	1	1
Serine/threonine-protein kinase Nek2	0	0	1	1
Serine/threonine-protein kinase Nek3	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 6	0	0	1	1
Serine/threonine-protein kinase PLK1	0	0	1	1
LIM domain kinase 1	0	0	1	1
LIM domain kinase 2	0	0	1	1
Tyrosine--tRNA ligase, cytoplasmic	0	0	1	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	1	2
Ephrin type-B receptor 3	0	0	1	1
Ephrin type-A receptor 5	0	0	1	1
Ephrin type-B receptor 4	0	0	1	1
Ephrin type-A receptor 4	0	0	1	1
Adenylate kinase 2, mitochondrial	0	0	1	1
Adenosine kinase	0	0	1	1
Cell division control protein 42 homolog	0	2	0	2
Ras-related protein Rab-10	0	0	1	1
Actin-related protein 3	0	0	1	1
Actin-related protein 2	0	0	1	1
GTP-binding nuclear protein Ran	0	0	1	1
Ras-related C3 botulinum toxin substrate 1	0	1	1	2
Casein kinase I isoform gamma-2	0	0	1	1
Cyclin-dependent kinase 3	0	0	1	1
Cyclin-dependent kinase 16	0	0	1	1
Cyclin-dependent kinase 17	0	0	1	1
ATP-dependent 6-phosphofructokinase, platelet type	0	0	1	1
Protein kinase C epsilon type	0	2	0	2
Dual specificity mitogen-activated protein kinase kinase 1	0	0	1	1
DNA topoisomerase 2-beta	0	0	1	1
Protein kinase C theta type	0	1	1	2
Activin receptor type-1	0	0	1	1
Macrophage-stimulating protein receptor	0	0	1	1
Focal adhesion kinase 1	0	0	1	1
Protein kinase C zeta type	0	1	1	2
Protein kinase C delta type	0	1	1	2
Tyrosine-protein kinase BTK	0	0	1	1
Activated CDC42 kinase 1	0	0	1	1
Epithelial discoidin domain-containing receptor 1	0	0	1	1
Myotonin-protein kinase	0	1	0	1
Mitogen-activated protein kinase kinase kinase kinase 2	0	0	1	1
Serine/threonine-protein kinase 4	0	0	1	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	1	2
Dual specificity mitogen-activated protein kinase kinase 5	0	0	1	1
Mitogen-activated protein kinase 7	0	0	1	1
Serine/threonine-protein kinase PAK 2	0	0	1	1
Serine/threonine-protein kinase 3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 1	0	0	1	1
Integrin-linked protein kinase	0	0	1	1
Rho-associated protein kinase 1	0	2	1	3
Non-receptor tyrosine-protein kinase TNK1	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit gamma	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit delta	0	0	1	1
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	0	1	1
Activin receptor type-2B	0	0	1	1
Bone morphogenetic protein receptor type-2	0	0	1	1
Protein-tyrosine kinase 6	0	0	1	1
cGMP-dependent protein kinase 1	0	0	1	1
Cyclin-dependent kinase 13	0	0	1	1
Inhibitor of nuclear factor kappa-B kinase subunit epsilon	0	0	1	1
Protein-tyrosine kinase 2-beta	0	0	1	1
Maternal embryonic leucine zipper kinase	0	0	1	1
Structural maintenance of chromosomes protein 1A	0	0	1	1
Chromodomain-helicase-DNA-binding protein 4	0	0	1	1
Peroxisomal acyl-coenzyme A oxidase 1	0	0	1	1
Ephrin type-A receptor 7	0	0	1	1
Delta(24)-sterol reductase	0	0	1	1
Ribosomal protein S6 kinase alpha-1	0	0	1	1
Dual specificity testis-specific protein kinase 1	0	0	1	1
Myosin light chain kinase, smooth muscle	0	3	1	4
Mitogen-activated protein kinase 11	0	0	1	1
Serine/threonine-protein kinase STK11	0	0	1	1
Serine/threonine-protein kinase N1	0	1	1	2
Serine/threonine-protein kinase N2	0	1	1	2
Calcium/calmodulin-dependent protein kinase type IV	0	0	1	1
Mitogen-activated protein kinase kinase kinase 11	0	0	1	1
Discoidin domain-containing receptor 2	0	0	1	1
Rho-associated protein kinase 2	0	1	0	1
AP2-associated protein kinase 1	0	0	1	1
Myosin light chain kinase 3	0	0	1	1
Uncharacterized aarF domain-containing protein kinase 5	0	0	1	1
Putative heat shock protein HSP 90-beta 2	0	0	1	1
Serine/threonine-protein kinase MRCK alpha	0	0	1	1
Serine/threonine-protein kinase MRCK gamma	0	0	1	1
Acyl-CoA dehydrogenase family member 10	0	0	1	1
Serine/threonine-protein kinase N3	0	0	1	1
Serine/threonine-protein kinase ULK3	0	0	1	1
Uncharacterized protein FLJ45252	0	0	1	1
Acyl-CoA dehydrogenase family member 11	0	0	1	1
Serine/threonine-protein kinase/endoribonuclease IRE2	0	0	1	1
Serine/threonine-protein kinase MARK2	0	0	1	1
ATP-dependent RNA helicase DHX30	0	0	1	1
Serine/threonine-protein kinase TAO1	0	0	1	1
STE20-related kinase adapter protein alpha	0	0	1	1
Myosin-14	0	0	1	1
AarF domain-containing protein kinase 1	0	0	1	1
ATP-dependent RNA helicase DDX42	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 3	0	0	1	1
MAP kinase-activated protein kinase 5	0	0	1	1
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B	0	0	1	1
Atypical kinase COQ8A, mitochondrial	0	0	1	1
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	0	0	1	1
Mitogen-activated protein kinase 15	0	0	1	1
Serine/threonine-protein kinase Nek9	0	0	1	1
Serine/threonine-protein kinase Nek7	0	0	1	1
ATP-dependent RNA helicase DDX1	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 1	0	0	1	1
MAP/microtubule affinity-regulating kinase 4	0	0	1	1
Serine/threonine-protein kinase Nek1	0	0	1	1
PAS domain-containing serine/threonine-protein kinase	0	0	1	1
Calcium/calmodulin-dependent protein kinase kinase 2	0	0	1	1
EKC/KEOPS complex subunit TP53RK	0	0	1	1
Dual specificity testis-specific protein kinase 2	0	0	1	1
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	0	0	1	1
Mitogen-activated protein kinase kinase kinase 5	0	0	1	1
Mitogen-activated protein kinase kinase kinase 3	0	0	1	1
Eukaryotic translation initiation factor 2-alpha kinase 1	0	0	1	1
Nucleolar GTP-binding protein 1	0	0	1	1
Serine/threonine-protein kinase D2	0	0	1	1
NUAK family SNF1-like kinase 2	0	0	1	1
RNA cytidine acetyltransferase	0	0	1	1
Serine/threonine-protein kinase SIK2	0	0	1	1
STE20-like serine/threonine-protein kinase	0	0	1	1
Serine/threonine-protein kinase TAO3	0	0	1	1
dCTP pyrophosphatase 1	0	0	1	1
Dual specificity protein kinase CLK4	0	0	1	1
Casein kinase I isoform gamma-1	0	0	1	1
Phenylalanine--tRNA ligase beta subunit	0	0	1	1
BMP-2-inducible protein kinase	0	0	1	1
Obg-like ATPase 1	0	0	1	1
Midasin	0	0	1	1
Interleukin-1 receptor-associated kinase 4	0	0	1	1
Mitogen-activated protein kinase kinase kinase 20	0	0	1	1
Cyclin-dependent kinase 12	0	0	1	1
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	0	0	1	1
Serine/threonine-protein kinase 26	0	0	1	1
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	0	0	1	1
Serine/threonine-protein kinase NLK	0	0	1	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	1	2
Serine/threonine-protein kinase TBK1	0	0	1	1
Septin-9	0	0	1	1
Ribosomal protein S6 kinase alpha-6	0	0	1	1
TRAF2 and NCK-interacting protein kinase	0	0	1	1
Serine/threonine-protein kinase TAO2	0	0	1	1
Long-chain-fatty-acid--CoA ligase 5	0	0	1	1
RAC-gamma serine/threonine-protein kinase	0	0	1	1
Serine/threonine-protein kinase SIK3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 2	0	0	1	1
Thyroid hormone receptor-associated protein 3	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 5	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 3	0	0	1	1
Serine/threonine-protein kinase MRCK beta	0	0	1	1
Interleukin-1 receptor-associated kinase 3	0	0	1	1
Casein kinase I isoform gamma-3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 4	0	0	1	1
D(4) dopamine receptor	0	3	0	3
Delta-type opioid receptor	0	10	3	15
Kappa-type opioid receptor	0	6	3	10
Histamine H1 receptor	0	3	1	4
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1	0	1	0	1
3-oxo-5-alpha-steroid 4-dehydrogenase 1	0	2	0	2
3-oxo-5-alpha-steroid 4-dehydrogenase 2	0	1	0	1
3-oxo-5-alpha-steroid 4-dehydrogenase 2	0	3	0	3
Cytochrome P450 2C19	0	9	0	9
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase	0	1	0	1
Chain A, Uracil Phosphoribosyltransferase	0	1	0	1
Skn7p	0	0	0	1
Solute carrier family 22 member 8	0	1	0	3
Thymidylate synthase	0	2	0	3
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	1
D(1A) dopamine receptor	9	0	0	9
Cocaine esterase	0	2	0	3
Arylacetamide deacetylase	0	0	0	1
Arylacetamide deacetylase	0	0	0	1
Arylacetamide deacetylase	0	0	0	1
Chain A, Dihydrofolate reductase	0	0	1	1
Thymidylate synthase	0	2	0	2
Dihydrofolate reductase	0	0	1	1
Folylpolyglutamate synthase, mitochondrial	0	0	0	1
Folylpolyglutamate synthase, mitochondrial	0	0	0	1
Multidrug resistance associated protein	0	0	0	1
Chain A, Estrogen receptor 1 (alpha)	0	1	0	1
Chain A, Transthyretin	0	0	1	1
Chain A, Transthyretin	0	0	1	1
Alpha-mannosidase	0	1	0	1
tyrosine-protein kinase Yes	1	0	0	1
Maltase-glucoamylase, intestinal	0	2	0	2
Steroid hormone receptor ERR2	0	1	0	1
Pancreatic triacylglycerol lipase	0	1	0	1
Steroid hormone receptor ERR1	0	2	0	2
Ornithine decarboxylase	0	1	0	1
Solute carrier family 2, facilitated glucose transporter member 4	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
Amine oxidase [flavin-containing] A	0	1	0	1
G1/S-specific cyclin-D1	0	1	0	1
Cruzipain	0	2	0	2
DNA (cytosine-5)-methyltransferase 1	0	1	0	1
Sodium-dependent serotonin transporter	0	4	0	4
Cystic fibrosis transmembrane conductance regulator	0	0	1	1
Alpha-glucosidase MAL32	0	1	0	1
Signal transducer and activator of transcription 3	0	1	0	1
Dual specificity mitogen-activated protein kinase kinase 4	0	1	0	1
Quinone oxidoreductase	0	0	0	4
Cytoplasmic tyrosine-protein kinase BMX	0	1	0	1
Oxysterols receptor LXR-beta	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
Oxysterols receptor LXR-alpha	0	1	0	1
Tissue alpha-L-fucosidase	0	1	0	1
DNA (cytosine-5)-methyltransferase 3-like	0	1	0	1
DNA (cytosine-5)-methyltransferase 3A	0	1	0	1
Chain A, Glutamine Binding Protein	0	0	1	1
Neutral amino acid transporter A	0	2	0	2
Asc-type amino acid transporter 1	0	2	0	2
Neutral amino acid transporter B(0)	0	2	0	2
Carbonic anhydrase-like protein, putative	0	0	0	1
Amino acid transporter	0	2	0	2
Chain B, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E	0	0	1	1
Glycine receptor subunit alpha-1	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	4	1	5
Sodium- and chloride-dependent glycine transporter 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	4	1	5
Glutamate receptor ionotropic, NMDA 2B	0	5	1	6
Glutamate receptor ionotropic, NMDA 2C	0	5	1	6
Large neutral amino acids transporter small subunit 1	0	4	0	4
Glutamate receptor ionotropic, NMDA 2D	0	4	1	5
Proton-coupled amino acid transporter 1	0	3	0	4
Glutamate receptor ionotropic, NMDA 3B	0	4	1	5
Serine racemase	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	4	1	5
Sodium- and chloride-dependent glycine transporter 2	0	1	0	1
Hypoxanthine-guanine phosphoribosyltransferase	0	0	0	1
Ricin	0	1	0	1
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	0	0	1	1
Purine nucleoside phosphorylase	0	0	1	2
Shiga toxin subunit A	0	1	0	1
Albumin	0	4	2	6
Voltage-dependent L-type calcium channel subunit alpha-1C	0	7	0	8
Liver carboxylesterase 1	0	1	0	3
Protein cereblon	0	2	0	2
N-glycosylase/DNA lyase	0	1	0	1
Aspartate aminotransferase, cytoplasmic	0	1	0	1
Single-stranded DNA cytosine deaminase	1	0	0	1
Chain A, membrane-associated prostaglandin E synthase-2	0	1	0	1
Prostaglandin E synthase	0	1	0	1
3',5'-cyclic-AMP phosphodiesterase	0	2	0	2
Solute carrier organic anion transporter family member 2B1	0	2	0	2
Cytochrome c oxidase subunit 2	0	1	0	1
Phospholipase A2, major isoenzyme	0	1	0	1
Interleukin-8	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	2	0	3
Aldo-keto reductase family 1 member B1	0	2	0	2
Aldo-keto reductase family 1 member C4	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Sodium-dependent dopamine transporter	0	2	0	2
Sodium- and chloride-dependent GABA transporter 1	0	2	0	2
Serum paraoxonase/arylesterase 1	0	2	0	2
Indoleamine 2,3-dioxygenase 1	0	2	0	2
Caspase-1	0	1	0	2
Sodium- and chloride-dependent GABA transporter 2	0	2	0	2
Sodium- and chloride-dependent GABA transporter 3	0	2	0	2
Bifunctional epoxide hydrolase 2	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Peroxisome proliferator-activated receptor gamma	0	0	1	1
Aldo-keto reductase family 1 member C3	0	2	0	2
Sodium- and chloride-dependent betaine transporter	0	2	0	2
C-X-C chemokine receptor type 3	0	1	0	1
Aldo-keto reductase family 1 member C2	0	1	0	1
Prostaglandin D2 receptor	0	2	0	2
Aldo-keto reductase family 1 member C1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	2
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Sigma intracellular receptor 2	0	2	0	2
Prostaglandin G/H synthase 1	0	1	0	1
Dehydrogenase/reductase SDR family member 9	0	1	0	1
P2Y purinoceptor 12	0	1	0	1
Prostaglandin D2 receptor 2	0	1	1	2
Neuronal acetylcholine receptor subunit beta-2	0	5	1	6
Neuronal acetylcholine receptor subunit alpha-7	0	3	2	5
Chymotrypsinogen A	0	1	0	1
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Acetylcholinesterase	0	3	0	3
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Cholinesterase	0	3	0	3
Glutamate receptor ionotropic, NMDA 1	0	2	0	2
Glutamate receptor ionotropic, NMDA 2A	0	2	0	2
Glutamate receptor ionotropic, NMDA 2B	0	2	0	2
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Fatty acid-binding protein, intestinal	0	1	1	2
Caspase-3	0	1	0	1
Caspase-4	0	1	0	1
Caspase-5	0	1	0	1
Caspase-9	0	1	0	1
Serine/threonine-protein kinase PAK 1	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Beta-2 adrenergic receptor	0	4	3	7
Beta-2 adrenergic receptor	0	3	2	7
Heparanase	0	0	1	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, Leucine Aminopeptidase	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
Phospholipase A-2-activating protein	0	1	0	1
Gonadotropin-releasing hormone receptor	0	1	0	1
Gonadotropin-releasing hormone receptor	0	2	0	2
Potassium voltage-gated channel subfamily A member 5	0	2	0	2
Sodium channel protein type 5 subunit alpha	0	4	0	4
Potassium voltage-gated channel subfamily D member 2	0	1	0	1
Potassium channel subfamily K member 18	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	4	0	4
isocitrate dehydrogenase 1, partial	2	0	0	2
Voltage-dependent L-type calcium channel subunit alpha-1F	0	5	0	5
Platelet-activating factor receptor	0	1	0	2
Voltage-dependent L-type calcium channel subunit alpha-1D	0	5	0	5
Voltage-dependent L-type calcium channel subunit alpha-1S	0	5	0	5
Nuclear receptor subfamily 3 group C member 3	0	4	0	4
Bile acid receptor	0	1	0	1
Sodium-dependent neutral amino acid transporter B(0)AT2	0	1	0	1
Histamine H4 receptor	0	1	0	1
Potassium channel subfamily K member 9	0	1	0	1
Type-1A angiotensin II receptor	0	1	0	1
Type-1B angiotensin II receptor	0	2	0	2
Type-2 angiotensin II receptor	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	3	0	3
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	3	0	3
5-hydroxytryptamine receptor 1A	0	1	0	1
Type-1 angiotensin II receptor	0	1	0	1
bioA	0	0	0	1
cystic fibrosis transmembrane conductance regulator	0	2	0	2
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Aminopeptidase	0	1	0	1
Chain A, Methionine aminopeptidase	0	1	0	1
S-ribosylhomocysteine lyase	0	1	0	1
Adenylate cyclase type 5	0	0	0	1
S-adenosylmethionine synthase isoform type-1	0	0	0	1
S-adenosylmethionine synthase isoform type-2	0	0	0	1
Fatty acid synthase	0	1	0	1
Chain E, Fibrin beta chain	0	1	0	1
T cell receptor, partial	1	0	0	1
luteinizing hormone receptor	1	0	0	1
integrase, partial	0	1	0	1
lens epithelium-derived growth factor p75	0	1	0	1
Caspase 6, apoptosis-related cysteine peptidase	0	0	0	1
TSHR protein	1	0	0	1
Apoptotic peptidase activating factor 1	0	1	0	1
luciferase	1	0	0	1
neutrophil cytosol factor 1	0	1	0	1
caspase-9 isoform alpha precursor	0	1	0	1
pyruvate kinase PKM isoform a	1	0	0	1
caspase-3 isoform a preproprotein	0	1	0	1
replicative DNA helicase	0	0	0	1
recombinase A	0	0	1	1
POsterior Segregation	0	0	1	1
Glutathione reductase	0	1	0	1
Glycoprotein hormones alpha chain	1	0	0	1
Albumin	0	0	0	1
Dihydrolipoyl dehydrogenase, mitochondrial	0	1	0	2
Microtubule-associated protein tau	0	1	1	2
Thioredoxin reductase 1, cytoplasmic	0	1	0	2
Dihydrolipoyl dehydrogenase	0	1	0	2
Zinc finger protein mex-5	0	0	1	1
phosphoglycerate kinase	2	0	0	2
Chain A, androgen receptor	0	0	1	1
Chain A, androgen receptor	0	0	1	1
ATP-dependent translocase ABCB1	0	2	0	2
Translocator protein	0	2	1	3
ATP-dependent translocase ABCB1	0	2	0	2
UDP-glucuronosyltransferase 2B10	0	1	0	1
Opioid receptor, delta 1b	0	1	0	1
Opioid receptor homologue	0	1	0	1
Acyl-CoA desaturase 1	0	1	0	1
Muscarinic acetylcholine receptor M1	0	6	0	6
Muscarinic acetylcholine receptor M3	0	6	0	6
Muscarinic acetylcholine receptor M4	0	5	0	5
Muscarinic acetylcholine receptor M5	0	4	0	4
Muscarinic acetylcholine receptor M2	0	6	0	6
Histidine decarboxylase	0	0	2	2
Proteinase-activated receptor 1	0	1	1	2
UDP-glucuronosyltransferase 1A3	0	0	0	1
Nociceptin receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
UDP-glucuronosyltransferase 1A8	0	0	0	2
5-hydroxytryptamine receptor 3E	0	2	1	4
Neuronal acetylcholine receptor subunit alpha-4	0	2	1	3
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
5-hydroxytryptamine receptor 3B	0	2	1	4
Acetylcholine receptor subunit alpha	0	2	1	3
Acetylcholine receptor subunit alpha	0	2	1	3
Acetylcholine receptor subunit beta	0	2	1	3
Acetylcholine receptor subunit gamma	0	2	1	3
Acetylcholine receptor subunit delta	0	2	1	3
Acetylcholine receptor subunit gamma	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-4	0	1	0	1
Acetylcholine receptor subunit beta	0	2	1	3
Acetylcholine receptor subunit beta-like 2	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-5	0	0	1	1
Neuronal acetylcholine receptor subunit beta-4	0	3	1	4
Muscarinic acetylcholine receptor M4	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-3	0	3	1	4
Neuronal acetylcholine receptor subunit alpha-4	0	4	1	5
5-hydroxytryptamine receptor 3A	0	3	1	5
Neuronal acetylcholine receptor subunit alpha-7	0	3	0	3
Acetylcholine-binding protein	0	1	1	2
Acetylcholine receptor subunit epsilon	0	0	1	1
Neuronal acetylcholine receptor subunit beta-3	0	1	1	2
Acetylcholine receptor subunit delta	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-6	0	1	1	2
Cytochrome P450 2A13	0	1	1	2
Neuronal acetylcholine receptor subunit alpha-5	0	2	0	2
Liver carboxylesterase B-1	0	1	0	1
5-hydroxytryptamine receptor 3D	0	2	1	4
Transient receptor potential cation channel subfamily A member 1	0	0	2	2
Neuronal acetylcholine receptor subunit beta-3	0	2	0	2
Neuronal acetylcholine receptor subunit beta-4	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-3	0	2	0	2
Soluble acetylcholine receptor	0	1	0	1
5-hydroxytryptamine receptor 3C	0	2	1	4
Neuronal acetylcholine receptor subunit alpha-2	0	2	0	2
Neuronal acetylcholine receptor subunit beta-2	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-6	0	2	0	2
Integrin beta	0	0	1	1
Glycoprotein IIb	0	0	1	1
Transporter	0	1	1	3
beta-2 adrenergic receptor	2	0	0	2
tumor necrosis factor	2	0	0	2
polyunsaturated fatty acid lipoxygenase ALOX12	2	0	0	2
atrial natriuretic peptide receptor 2 precursor	2	0	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	3	0	3
Phospholipase A2, membrane associated	0	1	0	2
5-hydroxytryptamine receptor 2A	0	4	0	4
Voltage-dependent L-type calcium channel subunit alpha-1C	0	4	0	4
Voltage-dependent L-type calcium channel subunit alpha-1D	0	2	0	2
Sodium channel protein type 1 subunit alpha	0	3	0	3
Sodium channel protein type 7 subunit alpha	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
C-terminal-binding protein 1	1	0	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	2	0	2
Leukotriene B4 receptor 1	0	0	0	1
Potassium channel subfamily K member 2	0	1	0	1
Indoleamine 2,3-dioxygenase 2	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
Leukotriene B4 receptor 2	0	0	0	1
Sodium channel protein type 11 subunit alpha	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	1	0	1
Sodium channel protein type 10 subunit alpha	0	1	0	1
Sodium/iodide cotransporter	0	1	0	1
5-hydroxytryptamine receptor 2C	0	1	0	1
Beta-2 adrenergic receptor	0	3	0	4
Beta-1 adrenergic receptor	0	4	1	6
Interleukin-6 receptor subunit alpha	0	1	0	1
5-hydroxytryptamine receptor 3A	0	1	0	1
Beta-3 adrenergic receptor	0	3	0	3
5-hydroxytryptamine receptor 1D	0	1	0	1
Cholecystokinin receptor type A	0	1	0	1
5-hydroxytryptamine receptor 1F	0	1	0	1
5-hydroxytryptamine receptor 2B	0	1	0	1
5-hydroxytryptamine receptor 6	0	1	0	1
Histamine H1 receptor	0	1	0	1
5-hydroxytryptamine receptor 7	0	1	0	1
5-hydroxytryptamine receptor 7	0	2	1	3
5-hydroxytryptamine receptor 5A	0	1	0	1
5-hydroxytryptamine receptor 5B	0	1	0	1
5-hydroxytryptamine receptor 3A	0	2	1	3
Thyrotropin-releasing hormone receptor	0	1	0	1
Glycine receptor subunit alpha-4	0	1	0	1
5-hydroxytryptamine receptor 4	0	1	0	1
5-hydroxytryptamine receptor 3B	0	1	0	1
5-hydroxytryptamine receptor 3B	0	2	1	3
Histamine H3 receptor	0	1	0	1
Leukotriene B4 receptor 1	0	1	0	1
MBT domain-containing protein 1	0	1	0	1
Lethal(3)malignant brain tumor-like protein 4	0	1	0	1
Lethal(3)malignant brain tumor-like protein 3	0	1	0	1
Lethal(3)malignant brain tumor-like protein 1	0	1	0	1
Nrf2	1	0	0	1
Microphthalmia-associated transcription factor	0	0	0	1
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase	0	1	0	1
caspase recruitment domain family, member 15	0	1	0	1
glucose-6-phosphate 1-dehydrogenase isoform b	0	1	0	1
receptor-interacting serine/threonine-protein kinase 2 isoform 1	0	1	0	1
Beta lactamase (plasmid)	0	1	0	1
WRN	1	0	0	1
Valosin-containing protein	0	1	0	1
microphthalmia-associated transcription factor isoform 9	0	1	0	1
eukaryotic translation initiation factor 4 gamma 1 isoform 4	0	1	0	1
eukaryotic translation initiation factor 4E isoform 1	0	1	0	1
Type II pantothenate kinase	0	0	0	1
Type III pantothenate kinase	0	0	0	1
Chain A, cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	0	1	0	1
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	1	0	1
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	0	1	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
Vascular endothelial growth factor receptor 1	0	1	0	1
Serine hydroxymethyltransferase, mitochondrial	0	1	0	1
Vascular endothelial growth factor receptor 3	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	0	2	0	2
Phosphodiesterase	0	1	0	1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	0	1	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase type 2	0	0	0	1
Metallo-beta-lactamase VIM-11	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-19	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase 1	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase SHV-1	0	0	0	1
Beta-lactamase SHV-1	0	0	0	1
Beta-lactamase OXA-10	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 15 member 1	0	1	0	1
Beta-lactamase TEM	0	1	0	2
Beta-lactamase	0	0	0	1
B2 metallo-beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	1	0	1
Metallo-beta-lactamase VIM-13	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Efflux transporter	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase Toho-1	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Class D beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-b-lactamase	0	0	0	1
Beta-lactamase IMP-1	0	0	0	1
BlaVIM-1	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Carbapenem-hydrolyzing beta-lactamase KPC	0	0	0	1
Beta-lactamase class B VIM-2	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 22 member 8	0	1	0	2
Beta-lactamase VIM-1	0	0	0	1
Sigma intracellular receptor 2	0	1	0	1
POU domain, class 2, transcription factor 1	0	0	0	1
Alpha-1B adrenergic receptor	0	1	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
5-hydroxytryptamine receptor 2A	0	0	1	1
Gamma-aminobutyric acid	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
luciferase	0	0	0	1
Glucocorticoid receptor	0	0	1	1
Glutamine synthetase	0	0	1	1
Histamine H1 receptor	0	1	1	2
Nociceptin receptor	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	0	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	0	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
Cytochrome P450 2C8	0	2	0	2
Endothelin-1 receptor	0	1	1	2
5-hydroxytryptamine receptor 1B	0	2	1	3
Neuromedin-K receptor	0	0	1	1
Type-1 angiotensin II receptor	0	1	1	2
Cholecystokinin receptor type A	0	1	1	2
Beta-1 adrenergic receptor	0	1	0	1
Beta-2 adrenergic receptor	0	1	0	1
Sodium/bile acid cotransporter	0	1	0	1
Nuclear receptor subfamily 2 group E member 1	0	0	2	2
N	0	1	0	1
tumor susceptibility gene 101 protein	1	0	0	1
Riboflavin-binding protein	0	2	2	4
Major prion protein	0	1	0	1
Histidine-rich protein PFHRP-II	0	1	0	1
DNA-directed RNA polymerase subunit alpha	0	1	0	1
DNA-directed RNA polymerase subunit omega	0	1	0	1
DNA-directed RNA polymerase subunit beta'	0	1	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
Phospholipase A2, membrane associated	0	1	0	1
Acidic phospholipase A2 2	0	1	0	1
Histamine H2 receptor	0	4	0	4
D(1A) dopamine receptor	2	0	0	2
Aldehyde oxidase 1	0	1	0	1
Cyclic GMP-AMP synthase	0	1	0	1
Chain A, 6,7-Dimethyl-8-ribityllumazine Synthase	0	0	1	1
Chain B, 6,7-Dimethyl-8-ribityllumazine Synthase	0	0	1	1
Chain A, Breast cancer type 1 susceptibility protein	1	0	0	1
Chain H, Immunoglobulin Igg1 Heavy chain	0	0	1	1
Chain L, Immunoglobulin Igg1 Lambda Light Chain	0	0	1	1
Chain A, DODECIN	0	0	1	1
Chain A, DODECIN	0	0	1	1
Chain C, DODECIN	0	0	1	1
Chain E, DODECIN	0	0	1	1
Caspase-7	1	0	0	1
Sphingosine kinase 2	0	2	0	2
Sphingosine kinase 1	0	1	0	1
Estrogen receptor beta	0	0	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	0	1
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Polymerase acidic protein	0	0	1	1
Stromelysin-1	0	0	1	1
Tyrosine-protein phosphatase YopH	0	1	0	1
High mobility group protein B1	0	0	1	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	3
Estrogen receptor	0	0	0	1
Cystathionine gamma-lyase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	0	1
Carbonic anhydrase	0	1	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
Interstitial collagenase	0	1	0	1
Type-1 angiotensin II receptor	0	1	0	1
Chain A, Mineralocorticoid receptor	0	1	0	1
Chain A, Mineralocorticoid receptor	0	1	0	1
GTPase HRas	0	1	0	1
DNA topoisomerase 1	0	1	0	1
Substance-P receptor	0	2	0	2
Neuromedin-K receptor	0	0	1	1
Substance-K receptor	0	1	1	2
Substance-P receptor	0	4	1	5
Neuromedin-K receptor	0	1	1	2
Substance-K receptor	0	1	0	1
Substance-K receptor	0	1	0	1
Growth hormone secretagogue receptor type 1	0	0	1	1
Chain A, MALTOPORIN	0	0	1	1
Chain B, MALTOPORIN	0	0	1	1
exodeoxyribonuclease V subunit RecD	0	1	0	1
exodeoxyribonuclease V subunit RecB	0	1	0	1
exodeoxyribonuclease V subunit RecC	0	1	0	1
ATP-dependent 6-phosphofructokinase	0	1	0	1
Dihydropteroate synthase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Endothelin-1 receptor	0	1	0	1
Protease	0	1	1	2
Protein-arginine deiminase type-4	0	1	0	1
Transcription regulator protein BACH1	0	1	0	1
Transcription factor MafK	0	1	0	1
Macrophage migration inhibitory factor	0	1	0	1
NAD	0	0	0	1
Kelch-like ECH-associated protein 1	0	1	2	3
Nuclear factor erythroid 2-related factor 2	0	1	2	4
Nuclear factor erythroid 2-related factor 2	0	0	0	1
NAD(P)H dehydrogenase [quinone] 1	0	0	0	1
Kelch-like ECH-associated protein 1	0	0	0	1
Chain A, CES1 protein	0	1	0	1
DNA polymerase III, partial	1	0	0	1
interferon gamma precursor	0	0	0	1
Lysosomal acid glucosylceramidase	0	0	1	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C alpha type	0	1	0	1
Protein kinase C delta type	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
Transcriptional activator protein LuxR	0	1	0	1
Protein kinase C eta type	0	1	0	1
B2 bradykinin receptor	0	2	0	2
Melanocortin receptor 4	0	2	0	2
Melanocortin receptor 5	0	2	0	2
Melanocortin receptor 3	0	2	0	2
Protein kinase C gamma type	0	1	0	1
Protein kinase C beta type	0	1	0	1
Phospholipase D1	0	1	0	1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	1	0	1
Platelet-activating factor acetylhydrolase	0	1	0	1
Phospholipase D1	0	1	0	1
Serine/threonine-protein kinase D1	0	1	0	1
Protein kinase C eta type	0	1	0	1
Emopamil-binding protein-like	0	1	0	1
7-dehydrocholesterol reductase	0	1	1	2
Protein kinase C theta type	0	1	0	1
Chain A, ykoF	0	0	1	1
Chain B, ykoF	0	0	1	1
Chain A, ThiT	0	0	1	1
Thiamine transporter ThiT	0	0	1	1
Transketolase	0	0	1	1
Thiamine-binding periplasmic protein	0	0	1	1
Thymidine kinase	0	1	0	2
Thymidine phosphorylase	0	0	0	1
Thymidine kinase, cytosolic	0	0	0	2
Thymidine kinase	0	1	0	2
Sterol O-acyltransferase 1	0	1	0	1
Thymidine kinase	0	0	0	1
Chain A, Carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Prolyl endopeptidase	0	1	0	1
Carbonic anhydrase-related protein 11	0	0	0	1
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Beta-carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase, alpha family	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Delta carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 13	0	1	0	1
Carbonic anhydrase 4	0	2	0	2
procathepsin L isoform 1 preproprotein	0	1	0	1
Chain A, Arginase 1	0	1	0	1
Histone deacetylase 3	0	2	0	2
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Histone deacetylase 4	0	2	0	2
Histone deacetylase 1	0	2	0	2
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member B7	0	1	0	1
Histone deacetylase 7	0	2	0	2
Histone deacetylase 2	0	2	0	2
Polyamine deacetylase HDAC10	0	2	0	2
Histone deacetylase 11	0	2	0	2
Histone deacetylase 8	0	2	0	2
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
Histone deacetylase 6	0	2	0	2
Histone deacetylase 9	0	2	0	2
Histone deacetylase 5	0	2	0	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

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Studies (630)

Protein Targets (1,751)

Hypospadias

Synonyms(1)

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Overview

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Treatment

Research

Studies (630)

Drugs Studied (264)

Protein Targets (1,751)