ketamine has been researched along with Cardiac Diseases in 13 studies
Ketamine: A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.
ketamine : A member of the class of cyclohexanones in which one of the hydrogens at position 2 is substituted by a 2-chlorophenyl group, while the other is substituted by a methylamino group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The antioxidant and cardioprotective effects of oleuropein have been reported in several studies; however, its effect on ketamine cardiotoxicity has not been known yet." | 7.96 | Protective effect of oleuropein on ketamine-induced cardiotoxicity in rats. ( Aydın, T; Borazan, Y; Çakır, A; Cellat, M; Çömez, MS; Gökçek, İ; Güvenç, M; Özkan, H; Özsoy, ŞY; Türk, E, 2020) |
| "This study aims at developing a population pharmacokinetic model for ketamine in children with cardiac diseases in order to rationalize an effective 2-h anesthetic medication, personalized based on cardiac function and age." | 5.20 | Population pharmacokinetics of ketamine in children with heart disease. ( Drover, DR; Elkomy, MH; Galinkin, JL; Hammer, GB; Ramamoorthy, C, 2015) |
| "The antioxidant and cardioprotective effects of oleuropein have been reported in several studies; however, its effect on ketamine cardiotoxicity has not been known yet." | 3.96 | Protective effect of oleuropein on ketamine-induced cardiotoxicity in rats. ( Aydın, T; Borazan, Y; Çakır, A; Cellat, M; Çömez, MS; Gökçek, İ; Güvenç, M; Özkan, H; Özsoy, ŞY; Türk, E, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (53.85) | 18.7374 |
| 1990's | 2 (15.38) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (23.08) | 24.3611 |
| 2020's | 1 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Park, S | 1 |
| Choi, AY | 1 |
| Park, E | 1 |
| Park, HJ | 1 |
| Lee, J | 1 |
| Lee, H | 1 |
| Kim, J | 1 |
| Cho, J | 1 |
| Çömez, MS | 1 |
| Cellat, M | 1 |
| Özkan, H | 1 |
| Borazan, Y | 1 |
| Aydın, T | 1 |
| Gökçek, İ | 1 |
| Türk, E | 1 |
| Güvenç, M | 1 |
| Çakır, A | 1 |
| Özsoy, ŞY | 1 |
| Elkomy, MH | 1 |
| Drover, DR | 1 |
| Hammer, GB | 1 |
| Galinkin, JL | 1 |
| Ramamoorthy, C | 1 |
| Ahiskalioglu, A | 1 |
| Ince, I | 1 |
| Aksoy, M | 1 |
| Ahiskalioglu, EO | 1 |
| Comez, M | 1 |
| Dostbil, A | 1 |
| Celik, M | 1 |
| Alp, HH | 1 |
| Coskun, R | 1 |
| Taghizadehghalehjoughi, A | 1 |
| Suleyman, B | 1 |
| Smirnova, VI | 1 |
| Hatano, S | 1 |
| Keane, DM | 1 |
| Boggs, RE | 1 |
| El-Naggar, MA | 1 |
| Sadove, MS | 1 |
| Savege, TM | 1 |
| Colvin, MP | 1 |
| Weaver, EJ | 1 |
| Bond, C | 1 |
| Drake, J | 1 |
| Inniss, R | 1 |
| Meshcheriakov, AV | 1 |
| Nurmatov, UB | 1 |
| Vinnitskiĭ, LI | 1 |
| Dement'eva, II | 1 |
| Egorova, IA | 1 |
| Brückner, JB | 1 |
| Gethmann, JW | 1 |
| Patschke, D | 1 |
| Tarnow, J | 1 |
| Weymar, A | 1 |
| Beer, R | 1 |
| Beer, D | 1 |
| Berkebile, PE | 1 |
| Marcy, JH | 1 |
| Hiles, DA | 1 |
| Stefano, G | 1 |
| D'Andrea, G | 1 |
| Di Corato, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pharmacokinetics of Ketamine in Infants and Children[NCT00553839] | 21 participants (Actual) | Interventional | 2007-07-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"pK analysis of ketamine in children with pre-existing congenital heart disease following a single dose of ketamine in order to rationalize an effective 2-h anesthetic medication, personalized based on cardiac function and age.~Residual Error was analyzed using Bootstrap model." (NCT00553839)
Timeframe: 5, 10, 15, 20, 30, 45, 60, 120, 180, 240, 300, 360 and 720 minutes after bolus.
| Intervention | proportional % (Median) |
|---|---|
| Single Group Assignment | 16.1 |
"pK analysis of ketamine in children with pre-existing congenital heart disease following a single dose of ketamine in order to rationalize an effective 2-h anesthetic medication, personalized based on cardiac function and age.~Central and Peripheral Volume of Distribution were analyzed using Bootstrap model." (NCT00553839)
Timeframe: 5, 10, 15, 20, 30, 45, 60, 120, 180, 240, 300, 360 and 720 minutes after bolus.
| Intervention | L/70kg (Median) | |
|---|---|---|
| Central Volume of Distribution | Peripheral Volume of Distribution | |
| Single Group Assignment | 57.6 | 149 |
"pK analysis of ketamine in children with pre-existing congenital heart disease following a single dose of ketamine in order to rationalize an effective 2-h anesthetic medication, personalized based on cardiac function and age.~Total Clearance and Intercompartmental Clearance were analyzed using Bootstrap model." (NCT00553839)
Timeframe: 5, 10, 15, 20, 30, 45, 60, 120, 180, 240, 300, 360 and 720 minutes after bolus.
| Intervention | L/h/70kg (Median) | |
|---|---|---|
| Total Clearance | Intercompartmental Clearance | |
| Single Group Assignment | 60.0 | 70.8 |
3 reviews available for ketamine and Cardiac Diseases
| Article | Year |
|---|---|
[Effects of anaesthetics on myocardial contractility].
Topics: Anesthetics; Animals; Blood Pressure; Cardiac Catheterization; Dogs; Drug Combinations; Halothane; H | 1973 |
Postoperative care.
Topics: Ambulatory Care; Anaphylaxis; Anesthesia; Anesthesia, Conduction; Eye Diseases; Heart Diseases; Hear | 1973 |
Anesthesia for pediatric ophthalmic operations.
Topics: Adolescent; Ambulatory Care; Anesthesiology; Atropine; Barbiturates; Brain Diseases; Child; Child, P | 1973 |
1 trial available for ketamine and Cardiac Diseases
| Article | Year |
|---|---|
Population pharmacokinetics of ketamine in children with heart disease.
Topics: Adolescent; Anesthetics, Dissociative; Child; Child, Preschool; Female; Heart Diseases; Humans; Infa | 2015 |
9 other studies available for ketamine and Cardiac Diseases
| Article | Year |
|---|---|
Effects of continuous ketamine infusion on hemodynamics and mortality in critically ill children.
Topics: Blood Pressure; Child, Preschool; Critical Illness; Female; Heart Diseases; Heart Rate; Hemodynamics | 2019 |
Protective effect of oleuropein on ketamine-induced cardiotoxicity in rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Cardiotoxicity; Disease Models, Animal; Heart Disea | 2020 |
Comparative Investigation of Protective Effects of Metyrosine and Metoprolol Against Ketamine Cardiotoxicity in Rats.
Topics: alpha-Methyltyrosine; Animals; Antioxidants; Biomarkers; Cytoprotection; Disease Models, Animal; DNA | 2015 |
[Anesthesia and infusion-transfusion therapy in extensive combined surgeries].
Topics: Analgesics, Opioid; Anesthesia, Endotracheal; Anesthesia, Epidural; Anesthesia, Intravenous; Combine | 1993 |
Diazepam-ketamine anaesthesia for open heart surgery a "micro-mini" drip administration technique.
Topics: Adolescent; Adult; Aged; Anesthesia, Intravenous; Blood Gas Analysis; Blood Pressure; Cardiac Surgic | 1976 |
A comparison of some cardiorespiratory effects of althesin and ketamine when used for induction of anaesthesia in patients with cardiac disease.
Topics: Alfaxalone Alfadolone Mixture; Anesthesia, Intravenous; Blood Pressure; Carbon Dioxide; Cardiac Outp | 1976 |
[Endocrine response to extracorporeal circulation].
Topics: Adult; Anesthesia, General; Dose-Response Relationship, Drug; Extracorporeal Circulation; Female; Fe | 1991 |
[Studies on the circulatory effects of etomidate in man (author's transl)].
Topics: Adult; Aged; Alfaxalone Alfadolone Mixture; Benzyl Compounds; Blood Circulation; Cardiac Output; Car | 1974 |
[Dissociative anesthesia in pediatric cardio-diagnosis].
Topics: Anesthesia; Angiocardiography; Cardiac Catheterization; Child; Child, Preschool; Heart Diseases; Hum | 1973 |