jnj-40411813 profile

1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone: an mGlu2 receptor modulator; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	25195461
CHEMBL ID	3337527
SCHEMBL ID	1035416
MeSH ID	M000602105

Synonym
bdbm50051408
chembl3337527 ,
SCHEMBL1035416
HY-15748
CS-3357
jnj-40411813
1127498-03-6
jnj 40411813 ,
HYOGJHCDLQSAHX-UHFFFAOYSA-N ,
1'-butyl-3'-chloro-4-phenyl-3,4,5,6-tetrahydro-2h,1 'h-[1,4']bipyridinyl-2'-one
1'-butyl-3'-chloro-4-phenyl-3,4,5,6-tetrahydro-2h,1'h-[1,4']bipyridinyl-2'-one
1'-butyl-3'-chloro-4-phenyl-3,4,5,6-tetrahydro-2h,1'h-[1,4]bipyridinyl-2'-one
612BYT76F3 ,
1'-butyl-3'-chloro-4-phenyl-3,4,5,6-tetrahydro-2h,1'h-(1,4')bipyridinyl-2'-one
2(1h)-pyridinone, 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-
1-butyl-3-chloro-4-(4-phenylpiperidin-1-yl)pyridin-2-one
jnj40411813
adx71149
adx-71149
gtpl8946
1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-2(1h)-pyridinone
1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1h)-pyridone
unii-612byt76f3
1-butyl-3-chloro-4-(4-phenylpiperidin-1-yl)pyridin-2(1h)-one
NCGC00485897-01
DB12059
FT-0752754
Q27895859
jnj-40411813; jnj 40411813; adx71149; adx 71149; adx-71149
BCP23709
EX-A2902
jnj-40411813; adx-71149
SB16990
adx 71149
A894527
F85059
MS-25297
adx-71149adx-71149
AC-35478
HZR ,
1-butyl-3-chloranyl-4-(4-phenylpiperidin-1-yl)pyridin-2-one
CVB49803
DTXSID601032323

Excerpt	Reference	Relevance
" The pharmacological and pharmacokinetic properties of a novel mGlu2 receptor-positive allosteric modulator (PAM), 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-2(1H)-pyridinone (JNJ-40411813/ADX71149) are described here."	( Pharmacological and pharmacokinetic properties of JNJ-40411813, a positive allosteric modulator of the mGlu2 receptor. Ahnaou, A; Drinkenburg, W; Langlois, X; Lavreysen, H; Le Poul, E; Lütjens, R; Mackie, C; Nuñez, JM; Pype, S; Trabanco, AA, 2015)	0.86

Excerpt	Reference	Relevance
"5 h) with an absolute oral bioavailability of 31%."	( Pharmacological and pharmacokinetic properties of JNJ-40411813, a positive allosteric modulator of the mGlu2 receptor. Ahnaou, A; Drinkenburg, W; Langlois, X; Lavreysen, H; Le Poul, E; Lütjens, R; Mackie, C; Nuñez, JM; Pype, S; Trabanco, AA, 2015)	0.67
"The ATP-binding cassette transporter P-glycoprotein (P-gp) is known to limit both brain penetration and oral bioavailability of many chemotherapy drugs."	( A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Ambudkar, SV; Brimacombe, KR; Chen, L; Gottesman, MM; Guha, R; Hall, MD; Klumpp-Thomas, C; Lee, OW; Lee, TD; Lusvarghi, S; Robey, RW; Shen, M; Tebase, BG, 2019)	0.51

Excerpt	Relevance	Reference
" The present paper addresses the effects on vigilance states of the mGluR2 positive allosteric modulator (PAM) JNJ-40411813 at different circadian times in rats and after afternoon dosing in humans."	( Translational neurophysiological markers for activity of the metabotropic glutamate receptor (mGluR2) modulator JNJ-40411813: Sleep EEG correlates in rodents and healthy men. Ahnaou, A; Cid, JM; de Boer, P; Drinkenburg, WH; Huysmans, H; Kemp, JA; Lavreysen, H; Macdonald, GJ; Raeymaekers, L; Sinha, V; Van De Casteele, T; Van Nueten, L, 2016)	0.86

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Metabotropic glutamate receptor 2	Homo sapiens (human)	IC50 (µMol)	0.0680	0.0029	0.4662	4.3000	AID1183964
Metabotropic glutamate receptor 2	Homo sapiens (human)	Ki	0.1800	0.0027	0.7158	6.4000	AID1319703
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Metabotropic glutamate receptor 2	Homo sapiens (human)	EC50 (µMol)	0.9168	0.0006	1.1784	8.5000	AID1183943; AID1319669; AID1319676; AID1319677; AID1319678; AID1319679; AID1319680; AID1319681; AID1319682
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Cytochrome P450 1A2	Homo sapiens (human)	INH	18.0000	0.1000	0.1000	0.1000	AID1184033
Cytochrome P450 3A4	Homo sapiens (human)	INH	18.0000	1.7000	2.8500	4.0000	AID1184035
Cytochrome P450 2D6	Homo sapiens (human)	INH	18.0000	3.2000	3.4000	3.6000	AID1184034
Cytochrome P450 2C9	Homo sapiens (human)	INH	6.0000	4.4000	7.0000	9.1000	AID1184036
5-hydroxytryptamine receptor 2A	Homo sapiens (human)	Kb	1.1000	0.0006	0.1689	1.1000	AID1184023
Cytochrome P450 2C19	Homo sapiens (human)	INH	7.0000	7.0000	7.0000	7.0000	AID1184037
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Process	via Protein(s)	Taxonomy
steroid catabolic process	Cytochrome P450 1A2	Homo sapiens (human)
porphyrin-containing compound metabolic process	Cytochrome P450 1A2	Homo sapiens (human)
xenobiotic metabolic process	Cytochrome P450 1A2	Homo sapiens (human)
cholesterol metabolic process	Cytochrome P450 1A2	Homo sapiens (human)
estrogen metabolic process	Cytochrome P450 1A2	Homo sapiens (human)
toxin biosynthetic process	Cytochrome P450 1A2	Homo sapiens (human)
post-embryonic development	Cytochrome P450 1A2	Homo sapiens (human)
alkaloid metabolic process	Cytochrome P450 1A2	Homo sapiens (human)
regulation of gene expression	Cytochrome P450 1A2	Homo sapiens (human)
monoterpenoid metabolic process	Cytochrome P450 1A2	Homo sapiens (human)
dibenzo-p-dioxin metabolic process	Cytochrome P450 1A2	Homo sapiens (human)
epoxygenase P450 pathway	Cytochrome P450 1A2	Homo sapiens (human)
lung development	Cytochrome P450 1A2	Homo sapiens (human)
methylation	Cytochrome P450 1A2	Homo sapiens (human)
monocarboxylic acid metabolic process	Cytochrome P450 1A2	Homo sapiens (human)
xenobiotic catabolic process	Cytochrome P450 1A2	Homo sapiens (human)
retinol metabolic process	Cytochrome P450 1A2	Homo sapiens (human)
long-chain fatty acid biosynthetic process	Cytochrome P450 1A2	Homo sapiens (human)
cellular respiration	Cytochrome P450 1A2	Homo sapiens (human)
aflatoxin metabolic process	Cytochrome P450 1A2	Homo sapiens (human)
hydrogen peroxide biosynthetic process	Cytochrome P450 1A2	Homo sapiens (human)
oxidative demethylation	Cytochrome P450 1A2	Homo sapiens (human)
cellular response to cadmium ion	Cytochrome P450 1A2	Homo sapiens (human)
omega-hydroxylase P450 pathway	Cytochrome P450 1A2	Homo sapiens (human)
lipid hydroxylation	Cytochrome P450 3A4	Homo sapiens (human)
lipid metabolic process	Cytochrome P450 3A4	Homo sapiens (human)
steroid catabolic process	Cytochrome P450 3A4	Homo sapiens (human)
xenobiotic metabolic process	Cytochrome P450 3A4	Homo sapiens (human)
steroid metabolic process	Cytochrome P450 3A4	Homo sapiens (human)
cholesterol metabolic process	Cytochrome P450 3A4	Homo sapiens (human)
androgen metabolic process	Cytochrome P450 3A4	Homo sapiens (human)
estrogen metabolic process	Cytochrome P450 3A4	Homo sapiens (human)
alkaloid catabolic process	Cytochrome P450 3A4	Homo sapiens (human)
monoterpenoid metabolic process	Cytochrome P450 3A4	Homo sapiens (human)
calcitriol biosynthetic process from calciol	Cytochrome P450 3A4	Homo sapiens (human)
xenobiotic catabolic process	Cytochrome P450 3A4	Homo sapiens (human)
vitamin D metabolic process	Cytochrome P450 3A4	Homo sapiens (human)
vitamin D catabolic process	Cytochrome P450 3A4	Homo sapiens (human)
retinol metabolic process	Cytochrome P450 3A4	Homo sapiens (human)
retinoic acid metabolic process	Cytochrome P450 3A4	Homo sapiens (human)
long-chain fatty acid biosynthetic process	Cytochrome P450 3A4	Homo sapiens (human)
aflatoxin metabolic process	Cytochrome P450 3A4	Homo sapiens (human)
oxidative demethylation	Cytochrome P450 3A4	Homo sapiens (human)
xenobiotic metabolic process	Cytochrome P450 2D6	Homo sapiens (human)
steroid metabolic process	Cytochrome P450 2D6	Homo sapiens (human)
cholesterol metabolic process	Cytochrome P450 2D6	Homo sapiens (human)
estrogen metabolic process	Cytochrome P450 2D6	Homo sapiens (human)
coumarin metabolic process	Cytochrome P450 2D6	Homo sapiens (human)
alkaloid metabolic process	Cytochrome P450 2D6	Homo sapiens (human)
alkaloid catabolic process	Cytochrome P450 2D6	Homo sapiens (human)
monoterpenoid metabolic process	Cytochrome P450 2D6	Homo sapiens (human)
isoquinoline alkaloid metabolic process	Cytochrome P450 2D6	Homo sapiens (human)
xenobiotic catabolic process	Cytochrome P450 2D6	Homo sapiens (human)
retinol metabolic process	Cytochrome P450 2D6	Homo sapiens (human)
long-chain fatty acid biosynthetic process	Cytochrome P450 2D6	Homo sapiens (human)
negative regulation of binding	Cytochrome P450 2D6	Homo sapiens (human)
oxidative demethylation	Cytochrome P450 2D6	Homo sapiens (human)
negative regulation of cellular organofluorine metabolic process	Cytochrome P450 2D6	Homo sapiens (human)
arachidonic acid metabolic process	Cytochrome P450 2D6	Homo sapiens (human)
xenobiotic metabolic process	Cytochrome P450 2C9	Homo sapiens (human)
steroid metabolic process	Cytochrome P450 2C9	Homo sapiens (human)
cholesterol metabolic process	Cytochrome P450 2C9	Homo sapiens (human)
estrogen metabolic process	Cytochrome P450 2C9	Homo sapiens (human)
monoterpenoid metabolic process	Cytochrome P450 2C9	Homo sapiens (human)
epoxygenase P450 pathway	Cytochrome P450 2C9	Homo sapiens (human)
urea metabolic process	Cytochrome P450 2C9	Homo sapiens (human)
monocarboxylic acid metabolic process	Cytochrome P450 2C9	Homo sapiens (human)
xenobiotic catabolic process	Cytochrome P450 2C9	Homo sapiens (human)
long-chain fatty acid biosynthetic process	Cytochrome P450 2C9	Homo sapiens (human)
amide metabolic process	Cytochrome P450 2C9	Homo sapiens (human)
icosanoid biosynthetic process	Cytochrome P450 2C9	Homo sapiens (human)
oxidative demethylation	Cytochrome P450 2C9	Homo sapiens (human)
omega-hydroxylase P450 pathway	Cytochrome P450 2C9	Homo sapiens (human)
temperature homeostasis	5-hydroxytryptamine receptor 2A	Homo sapiens (human)
positive regulation of cytokine production involved in immune response	5-hydroxytryptamine receptor 2A	Homo sapiens (human)
glycolytic process	5-hydroxytryptamine receptor 2A	Homo sapiens (human)
intracellular calcium ion homeostasis	5-hydroxytryptamine receptor 2A	Homo sapiens (human)
activation of phospholipase C activity	5-hydroxytryptamine receptor 2A	Homo sapiens (human)
positive regulation of cytosolic calcium ion concentration	5-hydroxytryptamine receptor 2A	Homo sapiens (human)
memory	5-hydroxytryptamine receptor 2A	Homo sapiens (human)
positive regulation of cell population proliferation	5-hydroxytryptamine receptor 2A	Homo sapiens (human)
response to xenobiotic stimulus	5-hydroxytryptamine receptor 2A	Homo sapiens (human)
positive regulation of phosphatidylinositol biosynthetic process	5-hydroxytryptamine receptor 2A	Homo sapiens (human)
regulation of dopamine secretion	5-hydroxytryptamine receptor 2A	Homo sapiens (human)
artery smooth muscle contraction	5-hydroxytryptamine receptor 2A	Homo sapiens (human)
urinary bladder smooth muscle contraction	5-hydroxytryptamine receptor 2A	Homo sapiens (human)
positive regulation of heat generation	5-hydroxytryptamine receptor 2A	Homo sapiens (human)
negative regulation of potassium ion transport	5-hydroxytryptamine receptor 2A	Homo sapiens (human)
phosphatidylinositol 3-kinase/protein kinase B signal transduction	5-hydroxytryptamine receptor 2A	Homo sapiens (human)
positive regulation of neuron apoptotic process	5-hydroxytryptamine receptor 2A	Homo sapiens (human)
protein localization to cytoskeleton	5-hydroxytryptamine receptor 2A	Homo sapiens (human)
positive regulation of fat cell differentiation	5-hydroxytryptamine receptor 2A	Homo sapiens (human)
positive regulation of glycolytic process	5-hydroxytryptamine receptor 2A	Homo sapiens (human)
positive regulation of vasoconstriction	5-hydroxytryptamine receptor 2A	Homo sapiens (human)
symbiont entry into host cell	5-hydroxytryptamine receptor 2A	Homo sapiens (human)
sensitization	5-hydroxytryptamine receptor 2A	Homo sapiens (human)
behavioral response to cocaine	5-hydroxytryptamine receptor 2A	Homo sapiens (human)
positive regulation of inflammatory response	5-hydroxytryptamine receptor 2A	Homo sapiens (human)
positive regulation of peptidyl-tyrosine phosphorylation	5-hydroxytryptamine receptor 2A	Homo sapiens (human)
detection of temperature stimulus involved in sensory perception of pain	5-hydroxytryptamine receptor 2A	Homo sapiens (human)
detection of mechanical stimulus involved in sensory perception of pain	5-hydroxytryptamine receptor 2A	Homo sapiens (human)
release of sequestered calcium ion into cytosol	5-hydroxytryptamine receptor 2A	Homo sapiens (human)
negative regulation of synaptic transmission, glutamatergic	5-hydroxytryptamine receptor 2A	Homo sapiens (human)
positive regulation of ERK1 and ERK2 cascade	5-hydroxytryptamine receptor 2A	Homo sapiens (human)
G protein-coupled serotonin receptor signaling pathway	5-hydroxytryptamine receptor 2A	Homo sapiens (human)
presynaptic modulation of chemical synaptic transmission	5-hydroxytryptamine receptor 2A	Homo sapiens (human)
positive regulation of execution phase of apoptosis	5-hydroxytryptamine receptor 2A	Homo sapiens (human)
positive regulation of platelet aggregation	5-hydroxytryptamine receptor 2A	Homo sapiens (human)
positive regulation of DNA biosynthetic process	5-hydroxytryptamine receptor 2A	Homo sapiens (human)
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	5-hydroxytryptamine receptor 2A	Homo sapiens (human)
phospholipase C-activating serotonin receptor signaling pathway	5-hydroxytryptamine receptor 2A	Homo sapiens (human)
serotonin receptor signaling pathway	5-hydroxytryptamine receptor 2A	Homo sapiens (human)
chemical synaptic transmission	5-hydroxytryptamine receptor 2A	Homo sapiens (human)
long-chain fatty acid metabolic process	Cytochrome P450 2C19	Homo sapiens (human)
xenobiotic metabolic process	Cytochrome P450 2C19	Homo sapiens (human)
steroid metabolic process	Cytochrome P450 2C19	Homo sapiens (human)
monoterpenoid metabolic process	Cytochrome P450 2C19	Homo sapiens (human)
epoxygenase P450 pathway	Cytochrome P450 2C19	Homo sapiens (human)
xenobiotic catabolic process	Cytochrome P450 2C19	Homo sapiens (human)
omega-hydroxylase P450 pathway	Cytochrome P450 2C19	Homo sapiens (human)
negative regulation of adenylate cyclase activity	Metabotropic glutamate receptor 2	Homo sapiens (human)
adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway	Metabotropic glutamate receptor 2	Homo sapiens (human)
chemical synaptic transmission	Metabotropic glutamate receptor 2	Homo sapiens (human)
gene expression	Metabotropic glutamate receptor 2	Homo sapiens (human)
glutamate secretion	Metabotropic glutamate receptor 2	Homo sapiens (human)
regulation of glutamate secretion	Metabotropic glutamate receptor 2	Homo sapiens (human)
regulation of dopamine secretion	Metabotropic glutamate receptor 2	Homo sapiens (human)
behavioral response to nicotine	Metabotropic glutamate receptor 2	Homo sapiens (human)
response to cocaine	Metabotropic glutamate receptor 2	Homo sapiens (human)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	Metabotropic glutamate receptor 2	Homo sapiens (human)
long-term synaptic depression	Metabotropic glutamate receptor 2	Homo sapiens (human)
intracellular glutamate homeostasis	Metabotropic glutamate receptor 2	Homo sapiens (human)
presynaptic modulation of chemical synaptic transmission	Metabotropic glutamate receptor 2	Homo sapiens (human)
regulation of response to drug	Metabotropic glutamate receptor 2	Homo sapiens (human)
G protein-coupled glutamate receptor signaling pathway	Metabotropic glutamate receptor 2	Homo sapiens (human)
regulation of synaptic transmission, glutamatergic	Metabotropic glutamate receptor 2	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
monooxygenase activity	Cytochrome P450 1A2	Homo sapiens (human)
iron ion binding	Cytochrome P450 1A2	Homo sapiens (human)
protein binding	Cytochrome P450 1A2	Homo sapiens (human)
electron transfer activity	Cytochrome P450 1A2	Homo sapiens (human)
oxidoreductase activity	Cytochrome P450 1A2	Homo sapiens (human)
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	Cytochrome P450 1A2	Homo sapiens (human)
enzyme binding	Cytochrome P450 1A2	Homo sapiens (human)
heme binding	Cytochrome P450 1A2	Homo sapiens (human)
demethylase activity	Cytochrome P450 1A2	Homo sapiens (human)
caffeine oxidase activity	Cytochrome P450 1A2	Homo sapiens (human)
aromatase activity	Cytochrome P450 1A2	Homo sapiens (human)
estrogen 16-alpha-hydroxylase activity	Cytochrome P450 1A2	Homo sapiens (human)
estrogen 2-hydroxylase activity	Cytochrome P450 1A2	Homo sapiens (human)
hydroperoxy icosatetraenoate dehydratase activity	Cytochrome P450 1A2	Homo sapiens (human)
monooxygenase activity	Cytochrome P450 3A4	Homo sapiens (human)
steroid binding	Cytochrome P450 3A4	Homo sapiens (human)
iron ion binding	Cytochrome P450 3A4	Homo sapiens (human)
protein binding	Cytochrome P450 3A4	Homo sapiens (human)
steroid hydroxylase activity	Cytochrome P450 3A4	Homo sapiens (human)
retinoic acid 4-hydroxylase activity	Cytochrome P450 3A4	Homo sapiens (human)
oxidoreductase activity	Cytochrome P450 3A4	Homo sapiens (human)
oxygen binding	Cytochrome P450 3A4	Homo sapiens (human)
enzyme binding	Cytochrome P450 3A4	Homo sapiens (human)
heme binding	Cytochrome P450 3A4	Homo sapiens (human)
vitamin D3 25-hydroxylase activity	Cytochrome P450 3A4	Homo sapiens (human)
caffeine oxidase activity	Cytochrome P450 3A4	Homo sapiens (human)
quinine 3-monooxygenase activity	Cytochrome P450 3A4	Homo sapiens (human)
testosterone 6-beta-hydroxylase activity	Cytochrome P450 3A4	Homo sapiens (human)
1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activity	Cytochrome P450 3A4	Homo sapiens (human)
anandamide 8,9 epoxidase activity	Cytochrome P450 3A4	Homo sapiens (human)
anandamide 11,12 epoxidase activity	Cytochrome P450 3A4	Homo sapiens (human)
anandamide 14,15 epoxidase activity	Cytochrome P450 3A4	Homo sapiens (human)
aromatase activity	Cytochrome P450 3A4	Homo sapiens (human)
vitamin D 24-hydroxylase activity	Cytochrome P450 3A4	Homo sapiens (human)
estrogen 16-alpha-hydroxylase activity	Cytochrome P450 3A4	Homo sapiens (human)
estrogen 2-hydroxylase activity	Cytochrome P450 3A4	Homo sapiens (human)
1,8-cineole 2-exo-monooxygenase activity	Cytochrome P450 3A4	Homo sapiens (human)
monooxygenase activity	Cytochrome P450 2D6	Homo sapiens (human)
iron ion binding	Cytochrome P450 2D6	Homo sapiens (human)
oxidoreductase activity	Cytochrome P450 2D6	Homo sapiens (human)
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	Cytochrome P450 2D6	Homo sapiens (human)
heme binding	Cytochrome P450 2D6	Homo sapiens (human)
anandamide 8,9 epoxidase activity	Cytochrome P450 2D6	Homo sapiens (human)
anandamide 11,12 epoxidase activity	Cytochrome P450 2D6	Homo sapiens (human)
anandamide 14,15 epoxidase activity	Cytochrome P450 2D6	Homo sapiens (human)
monooxygenase activity	Cytochrome P450 2C9	Homo sapiens (human)
iron ion binding	Cytochrome P450 2C9	Homo sapiens (human)
arachidonic acid epoxygenase activity	Cytochrome P450 2C9	Homo sapiens (human)
steroid hydroxylase activity	Cytochrome P450 2C9	Homo sapiens (human)
arachidonic acid 14,15-epoxygenase activity	Cytochrome P450 2C9	Homo sapiens (human)
arachidonic acid 11,12-epoxygenase activity	Cytochrome P450 2C9	Homo sapiens (human)
oxidoreductase activity	Cytochrome P450 2C9	Homo sapiens (human)
(S)-limonene 6-monooxygenase activity	Cytochrome P450 2C9	Homo sapiens (human)
(S)-limonene 7-monooxygenase activity	Cytochrome P450 2C9	Homo sapiens (human)
caffeine oxidase activity	Cytochrome P450 2C9	Homo sapiens (human)
(R)-limonene 6-monooxygenase activity	Cytochrome P450 2C9	Homo sapiens (human)
aromatase activity	Cytochrome P450 2C9	Homo sapiens (human)
heme binding	Cytochrome P450 2C9	Homo sapiens (human)
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	Cytochrome P450 2C9	Homo sapiens (human)
Gq/11-coupled serotonin receptor activity	5-hydroxytryptamine receptor 2A	Homo sapiens (human)
virus receptor activity	5-hydroxytryptamine receptor 2A	Homo sapiens (human)
G protein-coupled serotonin receptor activity	5-hydroxytryptamine receptor 2A	Homo sapiens (human)
protein binding	5-hydroxytryptamine receptor 2A	Homo sapiens (human)
protein tyrosine kinase activator activity	5-hydroxytryptamine receptor 2A	Homo sapiens (human)
identical protein binding	5-hydroxytryptamine receptor 2A	Homo sapiens (human)
protein-containing complex binding	5-hydroxytryptamine receptor 2A	Homo sapiens (human)
serotonin binding	5-hydroxytryptamine receptor 2A	Homo sapiens (human)
1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding	5-hydroxytryptamine receptor 2A	Homo sapiens (human)
neurotransmitter receptor activity	5-hydroxytryptamine receptor 2A	Homo sapiens (human)
monooxygenase activity	Cytochrome P450 2C19	Homo sapiens (human)
iron ion binding	Cytochrome P450 2C19	Homo sapiens (human)
steroid hydroxylase activity	Cytochrome P450 2C19	Homo sapiens (human)
oxidoreductase activity	Cytochrome P450 2C19	Homo sapiens (human)
(S)-limonene 6-monooxygenase activity	Cytochrome P450 2C19	Homo sapiens (human)
(S)-limonene 7-monooxygenase activity	Cytochrome P450 2C19	Homo sapiens (human)
oxygen binding	Cytochrome P450 2C19	Homo sapiens (human)
enzyme binding	Cytochrome P450 2C19	Homo sapiens (human)
heme binding	Cytochrome P450 2C19	Homo sapiens (human)
(R)-limonene 6-monooxygenase activity	Cytochrome P450 2C19	Homo sapiens (human)
aromatase activity	Cytochrome P450 2C19	Homo sapiens (human)
long-chain fatty acid omega-1 hydroxylase activity	Cytochrome P450 2C19	Homo sapiens (human)
arachidonic acid epoxygenase activity	Cytochrome P450 2C19	Homo sapiens (human)
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	Cytochrome P450 2C19	Homo sapiens (human)
G protein-coupled receptor activity	Metabotropic glutamate receptor 2	Homo sapiens (human)
calcium channel regulator activity	Metabotropic glutamate receptor 2	Homo sapiens (human)
protein binding	Metabotropic glutamate receptor 2	Homo sapiens (human)
glutamate receptor activity	Metabotropic glutamate receptor 2	Homo sapiens (human)
scaffold protein binding	Metabotropic glutamate receptor 2	Homo sapiens (human)
group II metabotropic glutamate receptor activity	Metabotropic glutamate receptor 2	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
endoplasmic reticulum membrane	Cytochrome P450 1A2	Homo sapiens (human)
intracellular membrane-bounded organelle	Cytochrome P450 1A2	Homo sapiens (human)
intracellular membrane-bounded organelle	Cytochrome P450 1A2	Homo sapiens (human)
cytoplasm	Cytochrome P450 3A4	Homo sapiens (human)
endoplasmic reticulum membrane	Cytochrome P450 3A4	Homo sapiens (human)
intracellular membrane-bounded organelle	Cytochrome P450 3A4	Homo sapiens (human)
mitochondrion	Cytochrome P450 2D6	Homo sapiens (human)
endoplasmic reticulum	Cytochrome P450 2D6	Homo sapiens (human)
endoplasmic reticulum membrane	Cytochrome P450 2D6	Homo sapiens (human)
cytoplasm	Cytochrome P450 2D6	Homo sapiens (human)
intracellular membrane-bounded organelle	Cytochrome P450 2D6	Homo sapiens (human)
endoplasmic reticulum membrane	Cytochrome P450 2C9	Homo sapiens (human)
plasma membrane	Cytochrome P450 2C9	Homo sapiens (human)
intracellular membrane-bounded organelle	Cytochrome P450 2C9	Homo sapiens (human)
cytoplasm	Cytochrome P450 2C9	Homo sapiens (human)
intracellular membrane-bounded organelle	Cytochrome P450 2C9	Homo sapiens (human)
neurofilament	5-hydroxytryptamine receptor 2A	Homo sapiens (human)
plasma membrane	5-hydroxytryptamine receptor 2A	Homo sapiens (human)
caveola	5-hydroxytryptamine receptor 2A	Homo sapiens (human)
axon	5-hydroxytryptamine receptor 2A	Homo sapiens (human)
cytoplasmic vesicle	5-hydroxytryptamine receptor 2A	Homo sapiens (human)
presynaptic membrane	5-hydroxytryptamine receptor 2A	Homo sapiens (human)
neuronal cell body	5-hydroxytryptamine receptor 2A	Homo sapiens (human)
dendritic shaft	5-hydroxytryptamine receptor 2A	Homo sapiens (human)
postsynaptic membrane	5-hydroxytryptamine receptor 2A	Homo sapiens (human)
cell body fiber	5-hydroxytryptamine receptor 2A	Homo sapiens (human)
glutamatergic synapse	5-hydroxytryptamine receptor 2A	Homo sapiens (human)
G protein-coupled serotonin receptor complex	5-hydroxytryptamine receptor 2A	Homo sapiens (human)
plasma membrane	5-hydroxytryptamine receptor 2A	Homo sapiens (human)
dendrite	5-hydroxytryptamine receptor 2A	Homo sapiens (human)
endoplasmic reticulum membrane	Cytochrome P450 2C19	Homo sapiens (human)
plasma membrane	Cytochrome P450 2C19	Homo sapiens (human)
intracellular membrane-bounded organelle	Cytochrome P450 2C19	Homo sapiens (human)
intracellular membrane-bounded organelle	Cytochrome P450 2C19	Homo sapiens (human)
cytoplasm	Cytochrome P450 2C19	Homo sapiens (human)
plasma membrane	Metabotropic glutamate receptor 2	Homo sapiens (human)
axon	Metabotropic glutamate receptor 2	Homo sapiens (human)
dendrite	Metabotropic glutamate receptor 2	Homo sapiens (human)
presynaptic membrane	Metabotropic glutamate receptor 2	Homo sapiens (human)
astrocyte projection	Metabotropic glutamate receptor 2	Homo sapiens (human)
glutamatergic synapse	Metabotropic glutamate receptor 2	Homo sapiens (human)
plasma membrane	Metabotropic glutamate receptor 2	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (155)

Assay ID	Title	Year	Journal	Article
AID1183943	Positive allosteric modulation of human mGlu2 receptor expressed in CHO cells assessed as potentiation of glutamate-induced effect incubated for 30 mins prior to [35S]GTPgamma addition measured after 30 mins	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1184023	Antagonist activity at 5HT2A receptor (unknown origin)	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1319678	Positive allosteric modulation at human mGlu2 receptor F643A mutant expressed in CHO-K1 cells assessed as potentiation of glutamate-induced effect incubated for 30 mins prior to [35S]GTPgamma addition measured after 30 mins by scintillation counting metho	2016	Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18	Discovery of 8-Trifluoromethyl-3-cyclopropylmethyl-7-[(4-(2,4-difluorophenyl)-1-piperazinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine (JNJ-46356479), a Selective and Orally Bioavailable mGlu2 Receptor Positive Allosteric Modulator (PAM).
AID1184041	Tmax in dog at 1 mg/kg, iv	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1183951	AUC (0 to infinity) in Sprague-Dawley rat at 10 mg/kg, po	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1183991	Selectivity for human mGlu2 receptor over ETA receptor (unknown origin)	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1319683	Lipophilicity, log P of the compound	2016	Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18	Discovery of 8-Trifluoromethyl-3-cyclopropylmethyl-7-[(4-(2,4-difluorophenyl)-1-piperazinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine (JNJ-46356479), a Selective and Orally Bioavailable mGlu2 Receptor Positive Allosteric Modulator (PAM).
AID1183994	Selectivity for human mGlu2 receptor over H2 receptor (unknown origin)	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1183993	Selectivity for human mGlu2 receptor over H1 receptor (unknown origin)	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1183946	Metabolic stability in rat liver microsomes assessed as compound metabolized at 5 uM after 15 mins by MS/MS analysis in presence of NADPH	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1183961	Positive allosteric modulation of mGlu2 receptor in Sprague-Dawley rat sleep-wake EEG paradigm model assessed as effect on deep sleep stage at 3 mg/kg, po after 4 hrs by electroencephalogram analysis	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1184000	Selectivity for human mGlu2 receptor over MC4 receptor (unknown origin)	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1184048	Therapeutic index, ratio of cardiotoxicity in anesthetized guinea pig to efficacy free concentration in Sprague-Dawley rat sleep-wake EEG paradigm model	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1319688	Fraction unbound in rat plasma assessed as free drug level at 5 uM by rapid equilibrium dialysis method	2016	Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18	Discovery of 8-Trifluoromethyl-3-cyclopropylmethyl-7-[(4-(2,4-difluorophenyl)-1-piperazinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine (JNJ-46356479), a Selective and Orally Bioavailable mGlu2 Receptor Positive Allosteric Modulator (PAM).
AID1184047	Therapeutic index, ratio of activity at rabbit purkinje fibre to efficacy free concentration in Sprague-Dawley rat sleep-wake EEG paradigm model	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1184027	Plasma protein binding in human	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1183975	Selectivity for human mGlu2 receptor over 5HT1A receptor (unknown origin)	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1184029	Plasma protein binding in mouse	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1184031	Apparent permeability from apical to basolateral side in human Caco2 cells	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1184035	Inhibition of human CYP3A4 (unknown origin)	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1319674	Metabolic stability in rat liver microsomes assessed as compound metabolized at 5 uM measured after 15 mins	2016	Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18	Discovery of 8-Trifluoromethyl-3-cyclopropylmethyl-7-[(4-(2,4-difluorophenyl)-1-piperazinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine (JNJ-46356479), a Selective and Orally Bioavailable mGlu2 Receptor Positive Allosteric Modulator (PAM).
AID1184042	Elimination half life in dog at 1 mg/kg, iv	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1319684	Dissociation constant, pKa of the compound	2016	Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18	Discovery of 8-Trifluoromethyl-3-cyclopropylmethyl-7-[(4-(2,4-difluorophenyl)-1-piperazinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine (JNJ-46356479), a Selective and Orally Bioavailable mGlu2 Receptor Positive Allosteric Modulator (PAM).
AID1183987	Selectivity for human mGlu2 receptor over CCR1 receptor (unknown origin)	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1319703	Displacement of [3H]8-Trifluoromethyl-3-cyclopropylmethyl-7-[(4-phenyl-1-piperidinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine from mGlu2 receptor (unknown origin)	2016	Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18	Discovery of 8-Trifluoromethyl-3-cyclopropylmethyl-7-[(4-(2,4-difluorophenyl)-1-piperazinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine (JNJ-46356479), a Selective and Orally Bioavailable mGlu2 Receptor Positive Allosteric Modulator (PAM).
AID1183989	Selectivity for human mGlu2 receptor over D2 receptor (unknown origin)	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1319676	Positive allosteric modulation of wild-type human mGlu2 receptor expressed in CHO-K1 cells assessed as potentiation of glutamate-induced effect incubated for 30 mins prior to [35S]GTPgamma addition measured after 30 mins by scintillation counting method	2016	Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18	Discovery of 8-Trifluoromethyl-3-cyclopropylmethyl-7-[(4-(2,4-difluorophenyl)-1-piperazinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine (JNJ-46356479), a Selective and Orally Bioavailable mGlu2 Receptor Positive Allosteric Modulator (PAM).
AID1183969	Binding affinity to rat mGlu6 receptor expressed in CHO cells assessed as calcium mobilization by [35S]GTPgamma binding assay	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1184036	Inhibition of human CYP2C9 (unknown origin)	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1184032	Apparent permeability from basolateral to apical side in human Caco2 cells	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1183948	Clearance in Sprague-Dawley rat at 2.5 mg/kg, iv	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1319699	Tmax in Beagle dog at 1 mg/kg, iv or 5 mg/kg, po	2016	Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18	Discovery of 8-Trifluoromethyl-3-cyclopropylmethyl-7-[(4-(2,4-difluorophenyl)-1-piperazinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine (JNJ-46356479), a Selective and Orally Bioavailable mGlu2 Receptor Positive Allosteric Modulator (PAM).
AID1319685	Solubility of the compound in water at pH 7.4	2016	Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18	Discovery of 8-Trifluoromethyl-3-cyclopropylmethyl-7-[(4-(2,4-difluorophenyl)-1-piperazinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine (JNJ-46356479), a Selective and Orally Bioavailable mGlu2 Receptor Positive Allosteric Modulator (PAM).
AID1184040	Volume of distribution at steady state in dog at 1 mg/kg, iv	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1319689	Fraction unbound in rat brain assessed as free drug level at 5 uM by rapid equilibrium dialysis method	2016	Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18	Discovery of 8-Trifluoromethyl-3-cyclopropylmethyl-7-[(4-(2,4-difluorophenyl)-1-piperazinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine (JNJ-46356479), a Selective and Orally Bioavailable mGlu2 Receptor Positive Allosteric Modulator (PAM).
AID1319719	Cmax in plasma of Sprague-Dawley rat sleep-wake EEG paradigm model as at 3 mg/kg, po	2016	Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18	Discovery of 8-Trifluoromethyl-3-cyclopropylmethyl-7-[(4-(2,4-difluorophenyl)-1-piperazinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine (JNJ-46356479), a Selective and Orally Bioavailable mGlu2 Receptor Positive Allosteric Modulator (PAM).
AID1183971	Selectivity ratio of IC50 for human mGlu3 receptor to IC50 for human mGlu2 receptor	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1319690	Clearance in Sprague-Dawley rat at 2.5 mg/kg, iv or 10 mg/kg, po	2016	Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18	Discovery of 8-Trifluoromethyl-3-cyclopropylmethyl-7-[(4-(2,4-difluorophenyl)-1-piperazinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine (JNJ-46356479), a Selective and Orally Bioavailable mGlu2 Receptor Positive Allosteric Modulator (PAM).
AID1184026	Solubility of the compound in 20% HP-beta-CD at pH 4	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1184034	Inhibition of human CYP2D6 (unknown origin)	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1183984	Selectivity for human mGlu2 receptor over beta1 receptor (unknown origin)	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1184010	Selectivity for human mGlu2 receptor over V1A receptor (unknown origin)	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1184018	Selectivity for human mGlu2 receptor over CICH receptor (unknown origin)	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1184015	Selectivity for human mGlu2 receptor over alpha2 receptor (unknown origin)	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1183985	Selectivity for human mGlu2 receptor over BK2 receptor (unknown origin)	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1183944	Positive allosteric modulation of human mGlu2 receptor expressed in CHO cells assessed as potentiation of glutamate-induced effect incubated for 30 mins prior to [35S]GTPgamma addition measured after 30 mins relative to glutamate	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1183962	Dissociation constant, pKa of the compound	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1319675	Inhibition of human ERG expressed in HEK293 cells assessed as reduction in maximal tail current at 3 uM and holding potential of -60 mV measured after 5 mins by patch-clamp assay	2016	Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18	Discovery of 8-Trifluoromethyl-3-cyclopropylmethyl-7-[(4-(2,4-difluorophenyl)-1-piperazinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine (JNJ-46356479), a Selective and Orally Bioavailable mGlu2 Receptor Positive Allosteric Modulator (PAM).
AID1319697	Clearance in Beagle dog at 1 mg/kg, iv or 5 mg/kg, po	2016	Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18	Discovery of 8-Trifluoromethyl-3-cyclopropylmethyl-7-[(4-(2,4-difluorophenyl)-1-piperazinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine (JNJ-46356479), a Selective and Orally Bioavailable mGlu2 Receptor Positive Allosteric Modulator (PAM).
AID1184051	Genotoxicity in human TK6 cells up to 150 ug/ml by in vitro micronucleus test	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1183958	Positive allosteric modulation of mGlu2 receptor in Sprague-Dawley rat sleep-wake EEG paradigm model assessed as effect on passive wake stage at 3 mg/kg, po after 4 hrs by electroencephalogram analysis	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1183959	Positive allosteric modulation of mGlu2 receptor in Sprague-Dawley rat sleep-wake EEG paradigm model assessed as effect on intermediate state at 3 mg/kg, po after 4 hrs by electroencephalogram analysis	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1183957	Positive allosteric modulation of mGlu2 receptor in Sprague-Dawley rat sleep-wake EEG paradigm model assessed as effect on active wake stage at 3 mg/kg, po after 4 hrs by electroencephalogram analysis	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1319673	Metabolic stability in human liver microsomes assessed as compound metabolized at 5 uM measured after 15 mins	2016	Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18	Discovery of 8-Trifluoromethyl-3-cyclopropylmethyl-7-[(4-(2,4-difluorophenyl)-1-piperazinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine (JNJ-46356479), a Selective and Orally Bioavailable mGlu2 Receptor Positive Allosteric Modulator (PAM).
AID1184039	Clearance in dog at 1 mg/kg, iv	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1183956	Positive allosteric modulation of mGlu2 receptor in Sprague-Dawley rat sleep-wake EEG paradigm model assessed as reduction in REM sleep at 3 mg/kg, po after 4 hrs by electroencephalogram analysis	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1319680	Positive allosteric modulation at human mGlu2 receptor N735D mutant expressed in CHO-K1 cells assessed as potentiation of glutamate-induced effect incubated for 30 mins prior to [35S]GTPgamma addition measured after 30 mins by scintillation counting metho	2016	Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18	Discovery of 8-Trifluoromethyl-3-cyclopropylmethyl-7-[(4-(2,4-difluorophenyl)-1-piperazinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine (JNJ-46356479), a Selective and Orally Bioavailable mGlu2 Receptor Positive Allosteric Modulator (PAM).
AID1183968	Binding affinity to human mGlu4 receptor expressed in rat L929 cells assessed as calcium mobilization by [35S]GTPgamma binding assay	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1184043	AUC (0 to infinity) in dog at 2.5 mg/kg, po	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1183999	Selectivity for human mGlu2 receptor over M3 receptor (unknown origin)	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1319691	Elimination half life in Sprague-Dawley rat at 2.5 mg/kg, iv or 10 mg/kg, po	2016	Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18	Discovery of 8-Trifluoromethyl-3-cyclopropylmethyl-7-[(4-(2,4-difluorophenyl)-1-piperazinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine (JNJ-46356479), a Selective and Orally Bioavailable mGlu2 Receptor Positive Allosteric Modulator (PAM).
AID1184016	Selectivity for human mGlu2 receptor over BZD receptor (unknown origin)	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1183979	Selectivity for human mGlu2 receptor over 5HT7 receptor (unknown origin)	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1319677	Positive allosteric modulation at human mGlu2 receptor L639A mutant expressed in CHO-K1 cells assessed as potentiation of glutamate-induced effect incubated for 30 mins prior to [35S]GTPgamma addition measured after 30 mins by scintillation counting metho	2016	Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18	Discovery of 8-Trifluoromethyl-3-cyclopropylmethyl-7-[(4-(2,4-difluorophenyl)-1-piperazinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine (JNJ-46356479), a Selective and Orally Bioavailable mGlu2 Receptor Positive Allosteric Modulator (PAM).
AID1183950	Tmax in Sprague-Dawley rat at 2.5 mg/kg, iv	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1184038	Volume of distribution at steady state in Sprague-Dawley rat at 2.5 mg/kg, iv	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1183986	Selectivity for human mGlu2 receptor over CCKA receptor (unknown origin)	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1183955	Positive allosteric modulation of mGlu2 receptor in po dosed Sprague-Dawley rat assessed effect on sleep-wake EEG paradigm after 20 hrs by electroencephalogram analysis	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1184003	Selectivity for human mGlu2 receptor over NK3 receptor (unknown origin)	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1183949	Elimination half life in Sprague-Dawley rat at 2.5 mg/kg, iv	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1319702	Oral bioavailability in Beagle dog at 5 mg/kg	2016	Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18	Discovery of 8-Trifluoromethyl-3-cyclopropylmethyl-7-[(4-(2,4-difluorophenyl)-1-piperazinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine (JNJ-46356479), a Selective and Orally Bioavailable mGlu2 Receptor Positive Allosteric Modulator (PAM).
AID1183996	Selectivity for human mGlu2 receptor over CXCR2 receptor (unknown origin)	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1183982	Selectivity for human mGlu2 receptor over A3 receptor (unknown origin)	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1184019	Selectivity for human mGlu2 receptor over GABA receptor (unknown origin)	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1184045	Oral bioavailability in dog at 2.5 mg/kg	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1607614	Positive allosteric modulation of mGluR2 (unknown origin) relative to control	2019	Journal of medicinal chemistry, 07-11, Volume: 62, Issue:13	Allosteric Modalities for Membrane-Bound Receptors: Insights from Drug Hunting for Brain Diseases.
AID1184012	Selectivity for human mGlu2 receptor over SST receptor (unknown origin)	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1183967	Binding affinity to human mGlu5 receptor expressed in HEK293 cells assessed as calcium mobilization by [35S]GTPgamma binding assay	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1319671	Kinetic solubility of the compound in 20% HP-beta-cyclodextrin at pH 4 by UPLC/UV method	2016	Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18	Discovery of 8-Trifluoromethyl-3-cyclopropylmethyl-7-[(4-(2,4-difluorophenyl)-1-piperazinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine (JNJ-46356479), a Selective and Orally Bioavailable mGlu2 Receptor Positive Allosteric Modulator (PAM).
AID1319701	Cmax in Beagle dog at 1 mg/kg, iv or 5 mg/kg, po	2016	Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18	Discovery of 8-Trifluoromethyl-3-cyclopropylmethyl-7-[(4-(2,4-difluorophenyl)-1-piperazinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine (JNJ-46356479), a Selective and Orally Bioavailable mGlu2 Receptor Positive Allosteric Modulator (PAM).
AID1319682	Positive allosteric modulation at human mGlu2 receptor F776A mutant expressed in CHO-K1 cells assessed as potentiation of glutamate-induced effect incubated for 30 mins prior to [35S]GTPgamma addition measured after 30 mins by scintillation counting metho	2016	Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18	Discovery of 8-Trifluoromethyl-3-cyclopropylmethyl-7-[(4-(2,4-difluorophenyl)-1-piperazinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine (JNJ-46356479), a Selective and Orally Bioavailable mGlu2 Receptor Positive Allosteric Modulator (PAM).
AID1183976	Selectivity for human mGlu2 receptor over 5HT3 receptor (unknown origin)	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1184001	Selectivity for human mGlu2 receptor over NET (unknown origin)	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1184044	Cmax in dog at 2.5 mg/kg, po	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1319681	Positive allosteric modulation at human mGlu2 receptor W773A mutant expressed in CHO-K1 cells assessed as potentiation of glutamate-induced effect incubated for 30 mins prior to [35S]GTPgamma addition measured after 30 mins by scintillation counting metho	2016	Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18	Discovery of 8-Trifluoromethyl-3-cyclopropylmethyl-7-[(4-(2,4-difluorophenyl)-1-piperazinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine (JNJ-46356479), a Selective and Orally Bioavailable mGlu2 Receptor Positive Allosteric Modulator (PAM).
AID1319695	Oral bioavailability in Sprague-Dawley rat at 10 mg/kg	2016	Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18	Discovery of 8-Trifluoromethyl-3-cyclopropylmethyl-7-[(4-(2,4-difluorophenyl)-1-piperazinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine (JNJ-46356479), a Selective and Orally Bioavailable mGlu2 Receptor Positive Allosteric Modulator (PAM).
AID1183953	Oral bioavailability in Sprague-Dawley rat at 10 mg/kg	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1319700	AUC (0 to infinity) in Beagle dog at 1 mg/kg, iv or 5 mg/kg, po	2016	Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18	Discovery of 8-Trifluoromethyl-3-cyclopropylmethyl-7-[(4-(2,4-difluorophenyl)-1-piperazinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine (JNJ-46356479), a Selective and Orally Bioavailable mGlu2 Receptor Positive Allosteric Modulator (PAM).
AID1184046	Positive allosteric modulation of mGlu2 receptor in po dosed Sprague-Dawley rat assessed free plasma drug level causing effect on sleep-wake EEG paradigm after 20 hrs by electroencephalogram analysis	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1184021	Selectivity for human mGlu2 receptor over NaCH receptor (unknown origin)	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1319698	Half life in Beagle dog at 1 mg/kg, iv or 5 mg/kg, po	2016	Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18	Discovery of 8-Trifluoromethyl-3-cyclopropylmethyl-7-[(4-(2,4-difluorophenyl)-1-piperazinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine (JNJ-46356479), a Selective and Orally Bioavailable mGlu2 Receptor Positive Allosteric Modulator (PAM).
AID1319725	Positive allosteric modulation of mGlu2 receptor in po dosed Sprague-Dawley rat sleep-wake EEG paradigm model assessed as lowest active dose required to show effect on sleep-wake cycle by electroencephalogram analysis	2016	Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18	Discovery of 8-Trifluoromethyl-3-cyclopropylmethyl-7-[(4-(2,4-difluorophenyl)-1-piperazinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine (JNJ-46356479), a Selective and Orally Bioavailable mGlu2 Receptor Positive Allosteric Modulator (PAM).
AID1183966	Binding affinity to human mGlu3 receptor expressed in HEK293 cells assessed as calcium mobilization by [35S]GTPgamma binding assay	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1183995	Selectivity for human mGlu2 receptor over IL8B receptor (unknown origin)	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1183952	Cmax in Sprague-Dawley rat at 10 mg/kg, po	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1183965	Binding affinity to human mGlu1 receptor expressed in HEK293 cells assessed as calcium mobilization by [35S]GTPgamma binding assay	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1184037	Inhibition of human CYP2C19 (unknown origin)	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1183960	Positive allosteric modulation of mGlu2 receptor in Sprague-Dawley rat sleep-wake EEG paradigm model assessed as effect on light sleep stage at 3 mg/kg, po after 4 hrs by electroencephalogram analysis	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1184024	Selectivity for human mGlu2 receptor over 5HT2A receptor (unknown origin)	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1183980	Selectivity for human mGlu2 receptor over A1 receptor (unknown origin)	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1319692	Tmax in Sprague-Dawley rat at 2.5 mg/kg, iv or 10 mg/kg, po	2016	Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18	Discovery of 8-Trifluoromethyl-3-cyclopropylmethyl-7-[(4-(2,4-difluorophenyl)-1-piperazinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine (JNJ-46356479), a Selective and Orally Bioavailable mGlu2 Receptor Positive Allosteric Modulator (PAM).
AID1184022	Selectivity for human mGlu2 receptor over SKCaCH receptor (unknown origin)	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1184013	Selectivity for human mGlu2 receptor over 5HT1B receptor (unknown origin)	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1319694	Cmax in Sprague-Dawley rat at 2.5 mg/kg, iv or 10 mg/kg, po	2016	Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18	Discovery of 8-Trifluoromethyl-3-cyclopropylmethyl-7-[(4-(2,4-difluorophenyl)-1-piperazinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine (JNJ-46356479), a Selective and Orally Bioavailable mGlu2 Receptor Positive Allosteric Modulator (PAM).
AID1319669	Positive allosteric modulation of human mGlu2 receptor expressed in CHO cell membranes assessed as potentiation of glutamate-induced effect incubated for 30 mins prior to [35S]GTPgamma addition measured after 30 mins by scintillation counting method	2016	Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18	Discovery of 8-Trifluoromethyl-3-cyclopropylmethyl-7-[(4-(2,4-difluorophenyl)-1-piperazinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine (JNJ-46356479), a Selective and Orally Bioavailable mGlu2 Receptor Positive Allosteric Modulator (PAM).
AID1184052	Genotoxicity in human TK6 cells up to 150 ug/ml by in vitro micronucleus test in presence of rat liver S9 fraction	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1319679	Positive allosteric modulation at wild type human mGlu2 receptor L732A mutant expressed in CHO-K1 cells assessed as potentiation of glutamate-induced effect preincubated for 30 mins prior to glutamate challenge measured after 30 mins by [35S]GTP-gammaS bi	2016	Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18	Discovery of 8-Trifluoromethyl-3-cyclopropylmethyl-7-[(4-(2,4-difluorophenyl)-1-piperazinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine (JNJ-46356479), a Selective and Orally Bioavailable mGlu2 Receptor Positive Allosteric Modulator (PAM).
AID1183945	Metabolic stability in human liver microsomes assessed as compound metabolized at 5 uM after 15 mins by MS/MS analysis in presence of NADPH	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1184011	Selectivity for human mGlu2 receptor over VIP receptor (unknown origin)	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1183997	Selectivity for human mGlu2 receptor over M1 receptor (unknown origin)	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1183974	Selectivity ratio of IC50 for rat mGlu6 receptor to IC50 for human mGlu2 receptor	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1183977	Selectivity for human mGlu2 receptor over 5HT5A receptor (unknown origin)	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1184008	Selectivity for human mGlu2 receptor over OP3 receptor (unknown origin)	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1184006	Selectivity for human mGlu2 receptor over NT1 receptor (unknown origin)	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1184004	Selectivity for human mGlu2 receptor over NPY1 receptor (unknown origin)	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1184030	Plasma protein binding in dog	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1183990	Selectivity for human mGlu2 receptor over DAT (unknown origin)	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1183988	Selectivity for human mGlu2 receptor over D1 receptor (unknown origin)	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1184020	Selectivity for human mGlu2 receptor over KCH receptor (unknown origin)	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1183964	Displacement of [3H]19 from human mGlu2 receptor expressed in CHO cells	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1184009	Selectivity for human mGlu2 receptor over ORL1 receptor (unknown origin)	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1183970	Selectivity ratio of IC50 for human mGlu1 receptor to IC50 for human mGlu2 receptor	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1184007	Selectivity for human mGlu2 receptor over OP1 receptor (unknown origin)	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1183983	Selectivity for human mGlu2 receptor over AT1 receptor (unknown origin)	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1184028	Plasma protein binding in rat	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1183981	Selectivity for human mGlu2 receptor over A2A receptor (unknown origin)	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1184025	Solubility of the compound in water	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1319696	Ratio of drug level in brain to plasma of Swiss mouse at 10 mg/kg, sc measured after 1 hr	2016	Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18	Discovery of 8-Trifluoromethyl-3-cyclopropylmethyl-7-[(4-(2,4-difluorophenyl)-1-piperazinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine (JNJ-46356479), a Selective and Orally Bioavailable mGlu2 Receptor Positive Allosteric Modulator (PAM).
AID1184017	Selectivity for human mGlu2 receptor over CaCH receptor (unknown origin)	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1183973	Selectivity ratio of IC50 for human mGlu4 receptor to IC50 for human mGlu2 receptor	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1183954	Ratio of drug level in brain to plasma in Swiss mouse at 10 mg/kg, sc after 1 hr	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1319670	Positive allosteric modulation of human mGlu2 receptor expressed in CHO cell membranes assessed as potentiation of glutamate-induced effect incubated for 30 mins prior to [35S]GTPgamma addition measured after 30 mins by scintillation counting method relat	2016	Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18	Discovery of 8-Trifluoromethyl-3-cyclopropylmethyl-7-[(4-(2,4-difluorophenyl)-1-piperazinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine (JNJ-46356479), a Selective and Orally Bioavailable mGlu2 Receptor Positive Allosteric Modulator (PAM).
AID1319668	Apparent permeability across apical to basolateral side over basolateral to apical side in human Caco2 cells at 1 uM measured after 120 mins	2016	Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18	Discovery of 8-Trifluoromethyl-3-cyclopropylmethyl-7-[(4-(2,4-difluorophenyl)-1-piperazinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine (JNJ-46356479), a Selective and Orally Bioavailable mGlu2 Receptor Positive Allosteric Modulator (PAM).
AID1184014	Selectivity for human mGlu2 receptor over alpha1 receptor (unknown origin)	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1319726	Positive allosteric modulation of mGlu2 receptor in po dosed Sprague-Dawley rat sleep-wake EEG paradigm model assessed as plasma concentration required to show effect on sleep-wake cycle by electroencephalogram analysis	2016	Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18	Discovery of 8-Trifluoromethyl-3-cyclopropylmethyl-7-[(4-(2,4-difluorophenyl)-1-piperazinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine (JNJ-46356479), a Selective and Orally Bioavailable mGlu2 Receptor Positive Allosteric Modulator (PAM).
AID1184002	Selectivity for human mGlu2 receptor over NK2 receptor (unknown origin)	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1183998	Selectivity for human mGlu2 receptor over M2 receptor (unknown origin)	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1319672	Kinetic solubility of the compound at pH 7 by UPLC/UV method	2016	Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18	Discovery of 8-Trifluoromethyl-3-cyclopropylmethyl-7-[(4-(2,4-difluorophenyl)-1-piperazinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine (JNJ-46356479), a Selective and Orally Bioavailable mGlu2 Receptor Positive Allosteric Modulator (PAM).
AID1184049	Therapeutic index, ratio of cardiotoxicity in anesthetized dog to efficacy free concentration in Sprague-Dawley rat sleep-wake EEG paradigm model	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1183972	Selectivity ratio of IC50 for human mGlu5 receptor to IC50 for human mGlu2 receptor	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1319686	Solubility of the compound in water at pH 2	2016	Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18	Discovery of 8-Trifluoromethyl-3-cyclopropylmethyl-7-[(4-(2,4-difluorophenyl)-1-piperazinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine (JNJ-46356479), a Selective and Orally Bioavailable mGlu2 Receptor Positive Allosteric Modulator (PAM).
AID1184005	Selectivity for human mGlu2 receptor over NPY2 receptor (unknown origin)	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1183978	Selectivity for human mGlu2 receptor over 5HT6 receptor (unknown origin)	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1183992	Selectivity for human mGlu2 receptor over GAL2 receptor (unknown origin)	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1183963	Lipophilicity, log P of the compound at pH 6.8	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1184050	Mutagenic activity in Salmonella typhimurium TA98 assessed as reverse mutation up to 125 ug/ml by Ames test	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1319693	AUC (0 to infinity) in Sprague-Dawley rat at 2.5 mg/kg, iv or 10 mg/kg, po	2016	Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18	Discovery of 8-Trifluoromethyl-3-cyclopropylmethyl-7-[(4-(2,4-difluorophenyl)-1-piperazinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine (JNJ-46356479), a Selective and Orally Bioavailable mGlu2 Receptor Positive Allosteric Modulator (PAM).
AID1184033	Inhibition of human CYP1A2 (unknown origin)	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1183947	Inhibition of human ERG channel transfected in HEK293 cells at 3 uM by patch clamp technique	2014	Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15	Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
AID1347160	Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors	2020	Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49	Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1296008	Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening	2020	SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1	Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening.
AID1347159	Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay	2020	Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49	Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1346986	P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen	2019	Molecular pharmacology, 11, Volume: 96, Issue:5	A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1346987	P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen	2019	Molecular pharmacology, 11, Volume: 96, Issue:5	A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1346271	Human mGlu2 receptor (Metabotropic glutamate receptors)	2015	Pharmacology research & perspectives, Feb, Volume: 3, Issue:1	Pharmacological and pharmacokinetic properties of JNJ-40411813, a positive allosteric modulator of the mGlu2 receptor.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	9 (81.82)	24.3611
2020's	2 (18.18)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	2 (18.18%)	5.53%
Reviews	2 (18.18%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	7 (63.64%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
ketamine Ketamine: A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.. ketamine : A member of the class of cyclohexanones in which one of the hydrogens at position 2 is substituted by a 2-chlorophenyl group, while the other is substituted by a methylamino group.	4.41	1	1	cyclohexanones; monochlorobenzenes; secondary amino compound	analgesic; environmental contaminant; intravenous anaesthetic; neurotoxin; NMDA receptor antagonist; xenobiotic
mdl 100907 Serotonin 5-HT2 Receptor Antagonists: Drugs that bind to but do not activate SEROTONIN 5-HT2 RECEPTORS, thereby blocking the actions of SEROTONIN or SEROTONIN 5-HT2 RECEPTOR AGONISTS. Included under this heading are antagonists for one or more specific 5-HT2 receptor subtypes.	2.13	1	0
oxadiazoles Oxadiazoles: Compounds containing five-membered heteroaromatic rings containing two carbons, two nitrogens, and one oxygen atom which exist in various regioisomeric forms.	3.31	1	0
piperidines Piperidines: A family of hexahydropyridines.	7.19	5	2

Condition	Indicated	Relationship Strength	Studies	Trials
Brain Disorders [description not available]	0	3.12	1	0
Brain Diseases Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This includes (but is not limited to) the CEREBRAL CORTEX; intracranial white matter; BASAL GANGLIA; THALAMUS; HYPOTHALAMUS; BRAIN STEM; and CEREBELLUM.	0	3.12	1	0
Congenital Zika Syndrome [description not available]	0	2.25	1	0
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	0	2.25	1	0
Zika Virus Infection A viral disease transmitted by the bite of AEDES mosquitoes infected with ZIKA VIRUS. Its mild DENGUE-like symptoms include fever, rash, headaches and ARTHRALGIA. The viral infection during pregnancy, in rare cases, is associated with congenital brain and ocular abnormalities, called Congenital Zika Syndrome, including MICROCEPHALY and may also lead to GUILLAIN-BARRE SYNDROME.	0	2.25	1	0
Depression, Involutional Form of depression in those MIDDLE AGE with feelings of ANXIETY.	0	3.12	1	0
Dementia Praecox [description not available]	0	3.12	1	0
Depressive Disorder, Major Disorder in which five (or more) of the following symptoms have been present during the same 2-week period and represent a change from previous functioning; at least one of the symptoms is either (1) depressed mood or (2) loss of interest or pleasure. Symptoms include: depressed mood most of the day, nearly every daily; markedly diminished interest or pleasure in activities most of the day, nearly every day; significant weight loss when not dieting or weight gain; Insomnia or hypersomnia nearly every day; psychomotor agitation or retardation nearly every day; fatigue or loss of energy nearly every day; feelings of worthlessness or excessive or inappropriate guilt; diminished ability to think or concentrate, or indecisiveness, nearly every day; or recurrent thoughts of death, recurrent suicidal ideation without a specific plan, or a suicide attempt. (DSM-5)	1	5.12	1	0
Schizophrenia A severe emotional disorder of psychotic depth characteristically marked by a retreat from reality with delusion formation, HALLUCINATIONS, emotional disharmony, and regressive behavior.	1	5.12	1	0
Smoking Cessation Discontinuing the habit of SMOKING.	0	4.41	1	1
Depression Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.	0	3.51	1	1

jnj-40411813

Description

Cross-References

Synonyms (43)

Research Excerpts

Pharmacokinetics

Bioavailability

Dosage Studied

Protein Targets (7)

Inhibition Measurements

Activation Measurements

Other Measurements

Biological Processes (95)

Molecular Functions (48)

Ceullar Components (19)

Bioassays (155)

Research

Studies (11)

Market Indicators

Research Demand Index: 28.55

Study Types

jnj-40411813

Description

Cross-References

Synonyms (43)

Research Excerpts

Pharmacokinetics

Bioavailability

Dosage Studied

Protein Targets (7)

Inhibition Measurements

Activation Measurements

Other Measurements

Biological Processes (95)

Molecular Functions (48)

Ceullar Components (19)

Bioassays (155)

Research

Studies (11)

Market Indicators

Research Demand Index: 28.55

Study Types

Related Drugs (4)

Related Conditions (11)