Entrapment Syndrome, Ulnar Nerve

Ulnar neuropathies caused by mechanical compression of the nerve at any location from its origin at the BRACHIAL PLEXUS to its terminations in the hand. Common sites of compression include the retroepicondylar groove, cubital tunnel at the elbow (CUBITAL TUNNEL SYNDROME), and Guyon's canal at the wrist. Clinical features depend on the site of injury, but may include weakness or paralysis of wrist flexion, finger flexion, and ulnar innervated intrinsic hand muscles, and impaired sensation over the ulnar aspect of the hand, fifth finger, and ulnar half of the ring finger. (Joynt, Clinical Neurology, 1995, Ch51, p43)

Synonym
Ulnar Nerve Compression Syndromes
Ulnar Nerve Compression
External Compression Syndrome, Ulnar Nerve
Entrapment Syndrome, Ulnar Nerve
Ulnar Nerve Entrapment
Ulnar Nerve Entrapment Syndrome
Guyon Syndrome
Ulnar Nerve External Compression Syndrome
Ulnar Nerve Entrapment at the Wrist

Excerpt	Reference
"Ulnar nerve entrapment is one of the most common entrapment neuropathies in the upper limb."	( Blecher, R; Loebenberg, M; Oron, A, 2010)
"Chronic ulnar nerve compression is believed to be the primary cause of sensory and motor impairments of the hand in cyclists, a condition termed Cyclist's Palsy."	( Ploeg, HL; Slane, J; Thelen, DG; Timmerman, M, 2011)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	4 (6.15)	23.3326
1990's	12 (18.46)	12.5806
2000's	24 (36.92)	18.1394
2010's	20 (30.77)	28.8240
2020's	5 (7.69)	9.53

Drug	Relationship Strength	Studies
alendronate	low	1
bupivacaine	low	2
glyphosate	low	1
lidocaine	low	1
ketamine	low	1
khellin	low	1
thalidomide	low	1
2,4-thiazolidinedione	low	1
methylprednisolone acetate	low	1
methylprednisolone	low	1
perfluorooctane	low	1
betamethasone	low	1
trolamine salicylate	low	2
fomesafen	low	1
betamethasone-17,21-dipropionate	low	1
humulene	low	1
aluminum	low	1

Protein Targets (176)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Maltase-glucoamylase, intestinal	0	1	0	1
Lysosomal alpha-glucosidase	0	1	0	1
Sucrase-isomaltase, intestinal	0	1	0	1
Glycogen synthase kinase-3 alpha	0	1	0	1
Glycogen synthase kinase-3 beta	0	1	0	1
Probable maltase-glucoamylase 2	0	1	0	1
Chain A, farnesyl pyrophosphate synthase	0	1	0	1
Geranylgeranyl pyrophosphate synthase	0	1	0	1
Farnesyl pyrophosphate synthase	0	2	0	2
Acetylcholinesterase	0	1	0	1
Hypoxanthine-guanine phosphoribosyltransferase	0	1	0	1
Farnesyl pyrophosphate synthase	0	1	0	1
Farnesyl pyrophosphate synthase	0	1	0	1
pregnane X receptor	1	0	0	1
GLI family zinc finger 3	4	0	0	4
AR protein	5	0	0	5
progesterone receptor	3	0	0	3
cytochrome P450 family 3 subfamily A polypeptide 4	4	0	0	4
glucocorticoid receptor [Homo sapiens]	3	0	0	3
estrogen-related nuclear receptor alpha	3	0	0	3
farnesoid X nuclear receptor	2	0	0	2
pregnane X nuclear receptor	4	0	0	4
estrogen nuclear receptor alpha	5	0	0	5
vitamin D (1,25- dihydroxyvitamin D3) receptor	4	0	0	4
IDH1	4	0	0	4
aryl hydrocarbon receptor	2	0	0	2
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	3	0	0	3
nuclear receptor subfamily 1, group I, member 2	3	0	0	3
thyroid hormone receptor beta isoform a	2	0	0	2
nuclear factor erythroid 2-related factor 2 isoform 2	3	0	0	3
galanin receptor type 3	0	1	0	1
nuclear factor erythroid 2-related factor 2 isoform 1	2	0	0	2
ATP-binding cassette sub-family C member 3	0	4	0	4
Multidrug resistance-associated protein 4	0	4	0	4
Voltage-dependent calcium channel gamma-2 subunit	1	0	0	1
Bile salt export pump	0	5	0	5
Glucocorticoid receptor	0	4	0	4
Glycine receptor subunit alpha-1	0	4	0	4
Glutamate receptor 2	1	0	0	1
Glycine receptor subunit beta	0	4	0	4
Glycine receptor subunit alpha-2	0	4	0	4
Glycine receptor subunit alpha-3	0	4	0	4
Canalicular multispecific organic anion transporter 1	0	4	0	4
ORF73	0	0	1	1
Potassium channel subfamily K member 3	0	2	0	2
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 2	0	1	1	2
Potassium channel subfamily K member 9	0	1	0	1
Luciferase	1	0	0	1
hypoxia-inducible factor 1 alpha subunit	2	0	0	2
peroxisome proliferator activated receptor gamma	1	0	0	1
Histone H2A.x	1	0	0	1
Chain A, 3-phosphoshikimate 1-carboxyvinyltransferase	0	1	0	1
Chain A, 3-phosphoshikimate 1-carboxyvinyltransferase	0	1	0	1
Glutamine synthetase	0	1	0	1
Cytochrome P450 71B1	0	1	0	2
Glutamine synthetase	0	1	0	1
2-dehydro-3-deoxyphosphooctonate aldolase	0	1	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	5	0	0	5
chromobox protein homolog 1	2	0	0	2
geminin	5	0	0	5
lamin isoform A-delta10	2	0	0	2
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Acetylcholinesterase	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Rap guanine nucleotide exchange factor 3	1	0	0	1
Glutamate receptor ionotropic, NMDA 1	0	2	0	2
Sodium channel protein type 4 subunit alpha	0	2	0	2
Cholinesterase	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	2	0	2
Glutamate receptor ionotropic, NMDA 2B	0	2	0	2
Glutamate receptor ionotropic, NMDA 2C	0	2	0	2
Glutamate receptor ionotropic, NMDA 1	0	2	0	2
Glutamate receptor ionotropic, NMDA 2A	0	2	0	2
Glutamate receptor ionotropic, NMDA 2B	0	2	0	2
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Glutamate receptor ionotropic, NMDA 2D	0	2	0	2
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	2	0	2
Glutamate receptor ionotropic, NMDA 3A	0	2	0	2
glp-1 receptor, partial	1	0	0	1
USP1 protein, partial	2	0	0	2
GALC protein	1	0	0	1
TDP1 protein	4	0	0	4
aldehyde dehydrogenase 1 family, member A1	3	0	0	3
nuclear receptor subfamily 1, group I, member 3	1	0	0	1
G	2	0	0	2
cytochrome P450 2D6	2	0	0	2
cytochrome P450 2D6 isoform 1	1	0	0	1
cytochrome P450 2C19 precursor	1	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	1	0	0	1
importin subunit beta-1 isoform 1	2	0	0	2
mitogen-activated protein kinase 1	2	0	0	2
snurportin-1	2	0	0	2
GTP-binding nuclear protein Ran isoform 1	2	0	0	2
peripheral myelin protein 22	1	0	0	1
survival motor neuron protein isoform d	1	0	0	1
cytochrome P450 3A4 isoform 1	2	0	0	2
histone acetyltransferase KAT2A isoform 1	1	0	0	1
Gamma-aminobutyric acid receptor subunit pi	2	0	0	2
Interferon beta	2	0	0	2
HLA class I histocompatibility antigen, B alpha chain	2	0	0	2
Cellular tumor antigen p53	1	0	0	1
Cytochrome P450 1A1	0	2	0	2
Cytochrome P450 1A2	0	2	0	2
Cytochrome P450 3A4	0	1	0	1
Cytochrome P450 2D6	0	1	0	1
Cytochrome P450 2C9	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	2	0	0	2
Gamma-aminobutyric acid receptor subunit delta	2	0	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-5	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	2	0	0	2
Gamma-aminobutyric acid receptor subunit gamma-1	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	2	0	0	2
Gamma-aminobutyric acid receptor subunit gamma-3	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-6	2	0	0	2
Cytochrome P450 2C19	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	2	0	0	2
Gamma-aminobutyric acid receptor subunit beta-3	2	0	0	2
Gamma-aminobutyric acid receptor subunit beta-2	2	0	0	2
Cytochrome P450 1B1	0	1	0	1
GABA theta subunit	2	0	0	2
Inositol hexakisphosphate kinase 1	2	0	0	2
Gamma-aminobutyric acid receptor subunit epsilon	2	0	0	2
cytochrome P450 2C9, partial	2	0	0	2
Chain A, Beta-lactamase	1	0	0	1
thioredoxin reductase	1	0	0	1
RAR-related orphan receptor gamma	3	0	0	3
GLS protein	1	0	0	1
Microtubule-associated protein tau	1	0	0	1
euchromatic histone-lysine N-methyltransferase 2	2	0	0	2
flap endonuclease 1	1	0	0	1
muscarinic acetylcholine receptor M1	1	0	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	1	0	1
Sodium channel protein type 5 subunit alpha	0	1	0	1
Sodium channel protein type 9 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily D member 2	0	1	0	1
Potassium channel subfamily K member 18	0	1	0	1
Multidrug and toxin extrusion protein 1	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
acetylcholinesterase	1	0	0	1
PPM1D protein	1	0	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	1	0	0	1
nonstructural protein 1	1	0	0	1
retinoid X nuclear receptor alpha	3	0	0	3
bromodomain adjacent to zinc finger domain 2B	1	0	0	1
muscleblind-like protein 1 isoform 1	1	0	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Androgen receptor	0	2	0	2
ATPase family AAA domain-containing protein 5	1	0	0	1
Ataxin-2	1	0	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
ATP-dependent phosphofructokinase	1	0	0	1
urokinase-type plasminogen activator precursor	1	0	0	1
plasminogen precursor	1	0	0	1
urokinase plasminogen activator surface receptor precursor	1	0	0	1
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Cereblon isoform 4	0	2	0	2
EWS/FLI fusion protein	1	0	0	1
arylsulfatase A	1	0	0	1
Bloom syndrome protein isoform 1	1	0	0	1
Prostaglandin G/H synthase 1	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
DNA-binding protein Ikaros	0	0	0	1
DNA damage-binding protein 1	0	1	1	2
Protein cereblon	0	2	1	4
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Entrapment Syndrome, Ulnar Nerve

Synonyms(9)

Research Excerpts

Overview

Research

Studies (65)

Protein Targets (176)

Entrapment Syndrome, Ulnar Nerve

Synonyms(9)

Research Excerpts

Overview

Research

Studies (65)

Drugs Studied (22)

Protein Targets (176)