ketamine has been researched along with Herpes Zoster in 8 studies
Ketamine: A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.
ketamine : A member of the class of cyclohexanones in which one of the hydrogens at position 2 is substituted by a 2-chlorophenyl group, while the other is substituted by a methylamino group.
Herpes Zoster: An acute infectious, usually self-limited, disease believed to represent activation of latent varicella-zoster virus (HERPESVIRUS 3, HUMAN) in those who have been rendered partially immune after a previous attack of CHICKENPOX. It involves the SENSORY GANGLIA and their areas of innervation and is characterized by severe neuralgic pain along the distribution of the affected nerve and crops of clustered vesicles over the area. (From Dorland, 27th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Four patients with postherpetic neuralgia had their pain alleviated by epidural administration of ketamine." | 7.71 | [Usefulness of epidural administration of ketamine for relief of postherpetic neuralgia]. ( Ikeda, M; Machida, K; Mikawa, Y; Mizuno, J; Sugimoto, S, 2001) |
| " The result strongly suggests a synergy from this combination that warrants a formal study of the dose-response relationship involved in this treatment and the mechanism by which this effect is achieved." | 5.29 | Epidural coadministration of ketamine, morphine and bupivacaine attenuates post-herpetic neuralgia--a case report. ( Cherng, CH; Ho, ST; Liaw, WJ; Shen, TT; Wong, CS, 1996) |
| "Four patients with postherpetic neuralgia had their pain alleviated by epidural administration of ketamine." | 3.71 | [Usefulness of epidural administration of ketamine for relief of postherpetic neuralgia]. ( Ikeda, M; Machida, K; Mikawa, Y; Mizuno, J; Sugimoto, S, 2001) |
| "A 74 year-old woman with a 6-month history of RSD following herpes zoster on her right arm was treated with stellate ganglion blocks (SGB), continuous epidural block (CEB) and continuous intravenous infusion of ketamine known as one of the NMDA receptor blockers." | 3.69 | [A case of RSD with complete disappearance of symptoms following intravenous ketamine infusion combined with stellate ganglion block and continuous epidural block]. ( Arakawa, H; Kato, J; Kishimoto, N; Ogawa, S; Suzuki, H; Suzuki, T, 1995) |
| "A post-herpetic neuralgia is thought to be a neuropathic pain due to the irreversible nerve injury and sensitization." | 2.41 | [Herpes zoster and post-herpetic neuralgia]. ( Hashizume, K, 2001) |
| " The result strongly suggests a synergy from this combination that warrants a formal study of the dose-response relationship involved in this treatment and the mechanism by which this effect is achieved." | 1.29 | Epidural coadministration of ketamine, morphine and bupivacaine attenuates post-herpetic neuralgia--a case report. ( Cherng, CH; Ho, ST; Liaw, WJ; Shen, TT; Wong, CS, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (37.50) | 18.2507 |
| 2000's | 4 (50.00) | 29.6817 |
| 2010's | 1 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Griffin, JR | 1 |
| Davis, MD | 1 |
| Quan, D | 1 |
| Wellish, M | 1 |
| Gilden, DH | 1 |
| Lovitt, S | 1 |
| Kishimoto, N | 1 |
| Kato, J | 1 |
| Suzuki, T | 1 |
| Arakawa, H | 1 |
| Ogawa, S | 1 |
| Suzuki, H | 1 |
| Wong, CS | 1 |
| Shen, TT | 1 |
| Liaw, WJ | 1 |
| Cherng, CH | 1 |
| Ho, ST | 1 |
| Klepstad, P | 1 |
| Borchgrevink, PC | 1 |
| Mizuno, J | 1 |
| Sugimoto, S | 1 |
| Ikeda, M | 2 |
| Machida, K | 1 |
| Mikawa, Y | 1 |
| Hashizume, K | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Antipruritic Effect of Topical Ketamine, Amitriptyline, and Lidocaine[NCT03096444] | Phase 2 | 13 participants (Actual) | Interventional | 2017-05-23 | Terminated (stopped due to Efficacy was not seen after interim analysis) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Peak itch intensity between the vehicle and 4 other active treatments (individual ketamine, amitriptyline, or lidocaine, and KeAmLi-combo). Itch intensity was measured on a 100mm scale visual analog scale for 10 minutes. 0 was weighted with no itch and 100 was weighted with most itch imaginable." (NCT03096444)
Timeframe: 10 minutes
| Intervention | Intensity score (Mean) |
|---|---|
| Topical KeAmLi Combo | 62.7 |
| Topical Ketamine | 63.1 |
| Topical Amitriptyline | 69.2 |
| Topical Lidocaine | 65.8 |
| Topical Vehicle | 61.9 |
Assess mechanical detection and pain thresholds using von Frey filaments stimulators (measured in force mN) to calculate the final threshold as the geometric mean of five series of ascending and descending stimuli. (NCT03096444)
Timeframe: 5 minutes
| Intervention | mN (Mean) | |
|---|---|---|
| Mechanical Detection Threshold | Mechanical Pain Threshold | |
| Topical Amitriptyline | 3.573423965 | 152.4768146 |
| Topical KeAmLi Combo | 3.519376956 | 152.3293608 |
| Topical Ketamine | 3.464204768 | 135.9 |
| Topical Lidocaine | 3.546037659 | 126.9 |
| Topical Vehicle | 3.525692637 | 148.7138273 |
Two standardized quantitative sensory tests are performed to measure warmth detection threshold (assesses the threshold of which warmth sensation is first detected) and heat pain threshold (assesses the threshold at which heat pain sensation is first detected). Measured in change in celsius. (NCT03096444)
Timeframe: 3 minutes
| Intervention | Degrees celsius (Mean) | |
|---|---|---|
| Warm Detection Threshold | Heat Pain Threshold | |
| Topical Amitriptyline | 33.9 | 40.0 |
| Topical KeAmLi Combo | 33.6 | 39.8 |
| Topical Ketamine | 34.0 | 40.0 |
| Topical Lidocaine | 33.7 | 39.4 |
| Topical Vehicle | 33.8 | 39.7 |
2 reviews available for ketamine and Herpes Zoster
| Article | Year |
|---|---|
Topical ketamine treatment of postherpetic neuralgia.
Topics: Administration, Cutaneous; Analgesics, Non-Narcotic; Drug Evaluation; Female; Gels; Herpes Zoster; H | 2003 |
[Herpes zoster and post-herpetic neuralgia].
Topics: Anticonvulsants; Antidepressive Agents, Tricyclic; Autonomic Nerve Block; Carbamazepine; Epidural Sp | 2001 |
6 other studies available for ketamine and Herpes Zoster
| Article | Year |
|---|---|
Amitriptyline/Ketamine as therapy for neuropathic pruritus and pain secondary to herpes zoster.
Topics: Administration, Cutaneous; Amitriptyline; Analgesics; Drug Combinations; Gels; Herpes Zoster; Humans | 2015 |
Patient pages. Treatment of postherpetic neuralgia.
Topics: Administration, Topical; Adult; Chickenpox; Chickenpox Vaccine; Child; gamma-Aminobutyric Acid; Gels | 2003 |
[A case of RSD with complete disappearance of symptoms following intravenous ketamine infusion combined with stellate ganglion block and continuous epidural block].
Topics: Aged; Analgesia, Epidural; Autonomic Nerve Block; Excitatory Amino Acid Antagonists; Female; Herpes | 1995 |
Epidural coadministration of ketamine, morphine and bupivacaine attenuates post-herpetic neuralgia--a case report.
Topics: Adult; Analgesia, Epidural; Bupivacaine; Drug Therapy, Combination; Herpes Zoster; Humans; Ketamine; | 1996 |
Four years' treatment with ketamine and a trial of dextromethorphan in a patient with severe post-herpetic neuralgia.
Topics: Aged; Dextromethorphan; Excitatory Amino Acid Antagonists; Herpes Zoster; Humans; Ketamine; Male; Ne | 1997 |
[Usefulness of epidural administration of ketamine for relief of postherpetic neuralgia].
Topics: Aged; Analgesia, Epidural; Bupivacaine; Drug Therapy, Combination; Female; Herpes Zoster; Humans; In | 2001 |